• Organ-chips from Emulate, Mimetas and CNBio
  • Micro-patterned <em>in vitro</em> model of keratinocyte colonies
  • Cells growing in oil droplet model
  • Villi-like structures inside Emulate's intestine-chip
  • Ciliated cells inside Emulate’s lung-chip

A World-Leading Centre for Predictive in vitro Model Research, Training and Translation

The Queen Mary, Centre for Predictive in vitro Models (CPM) provides a beacon of multidisciplinary research, training, and translation focusing on the development and use of predictive in vitro models. This incorporates a wide range of model systems including 2D and 3D cell culture models, organoids, microphysiological systems, organ-on-a-chip technology, Non Animal Methods (NAMs), and other types of in vitro model.

Our vision is to facilitate the implementation of innovative in vitro models for highest quality discovery science and to accelerate delivery of safe and effective therapeutics for the benefit of wider society.

With approximately 70 academic staff across the Faculty of Science and Engineering and the Faculty of Medicine and Dentistry, Queen Mary's Centre for Predictive in vitro Models is leading development and use of these complex in vitro models in partnership the regulatory authorities, pharmaceuticals and healthcare industry, companies developing the technology platforms, and other stake holders.

Queen Mary led the UK Organ-on-a-Chip Technologies Network funded by UKRI (2018-2022) with over 1,000 members from 60+ universities and multiple stake holder partners, successfully establishing the organ-chip community in the UK. Queen Mary continues to provide leadership in this field hosting the annual UK symposium and engaging with Government, policy makers, funders, industry and other stake holders to support development and adoption of this transformative technology.

Events

News

Recent Publications

  • Allen O, Knight MM and Verbruggen SW (2024). Air Pollution and Osteoporosis. Current Osteoporosis Reports, Springer Science and Business Media LLC 
    20-09-2024
  • Ogrodnik M, Carlos Acosta J, Adams PD, d'Adda di Fagagna F, Baker DJ, Bishop CL, Chandra T, Collado M, Gil J, Gorgoulis V, Gruber F, Hara E, Jansen-Dürr P, Jurk D, Khosla S, Kirkland JL, Krizhanovsky V, Minamino T, Niedernhofer LJ, Passos JF, Ring NAR, Redl H, Robbins PD, Rodier F, Scharffetter-Kochanek K, Sedivy JM, Sikora E, Witwer K, von Zglinicki T and Yun MH (2024). Guidelines for minimal information on cellular senescence experimentation in vivo. Cell, Elsevier vol. 187 (16), 4150-4175.  
    01-08-2024
  • Lujan C, Tyler EJ, Ecker S, Webster AP, Stead ER, Martinez-Miguel VE, Milligan D, Garbe JC, Stampfer MR, Beck S, Lowe R, Bishop CL and Bjedov I (2024). An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo. Genome Medicine, Springer Nature vol. 16 (1) 
    02-07-2024

View more publications »

Recent Grants

Organ-chip Facility: A world-class in vitro models facility for the UK community, reducing the barriers to adoption to drive animal replacement
Hazel Screen, Stefaan Verbruggen, Martin Knight, Julia Shelton, Timothy Hopkins and John Connelly
£573,536 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research (07-10-2024 - 14-03-2025)
The role of novel mechanosensitive complex in cardiomyocyte pathophysiology
Thomas Iskratsch and Andrew Tinker
£254,588 BHF British Heart Foundation (01-10-2024 - 30-09-2027)
Unravelling mechanisms of drug-induced myocarditis using immune-responsive human cardiovascular chip
Yung-Yao Lin and Julien Gautrot
£121,420 MRC Medical Research Council (01-10-2024 - 30-09-2028)

View more grants »