The exploratory research program Organs and organoids on chips (PEPR MED-OOC) aims to deploy a new generation of biological models in France through the development of organs and organoids on chips (O&OoC). The State has entrusted its management to the CEA, the CNRS and Inserm, and the scientific direction to Xavier Gidrol (CEA), Anne-Marie Gué (CNRS), and Jean Rosenbaum (Inserm). MED-OOC is funded by France 2030 over 6 years and has a budget of €48.4 million operated by the National Research Agency (ANR).