Publications
The following journal papers published by the members of the CPM, specifically relate to the development and/or use of predictive in vitro models.
- Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood‐brain barrier: Therapeutic avenues
Sheikh MH, Errede M, d'Amati A, Khan NQ, Fanti S, Loiola RA, McArthur S, Purvis GSD, O'Riordan CE, Ferorelli D, Dell'Erba A, Kieswich J, Reutelingsperger C, Maiorano E, Yaqoob M, Thiemermann C, Baragetti A, Catapano AL, Norata GD, Marelli‐Berg F, Virgintino D and Solito E
The Faseb Journal, Wiley vol. 36 (1)
23-12-2021 - Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide
Hoyles L, Pontifex M, Rodriguez-Ramiro I, Anis-Alavi MA, Jelane KS, Snelling T, Solito E, Fonseca S, Carvalho AL, Carding SR, Muller M, Glen RC, Vauzour D and Mcarthur S
Microbiome, Biomed Central
27-11-2021 - Long term expansion profile of mesenchymal stromal cells at protein nanosheet-stabilised bioemulsions for next generation cell culture microcarriers
Peng L and Gautrot JE
Materials Today Bio, Elsevier vol. 12, 100159-100159.
16-11-2021 - Biological Significance and Targeting of the FGFR Axis in Cancer
Chioni A-M and Grose RP
Cancers, Mdpi vol. 13 (22)
13-11-2021 - Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors
Raynold AAM, Li D, Chang L and Gautrot JE
Nature Communications, Springer Nature vol. 12 (1)
08-11-2021 - Mannose Metabolism Is a Metabolic Vulnerability Unveiled By Standard and Novel Therapies in Acute Myeloid Leukemia
Woodley K, Dillingh LS, Giotopoulos G, Madrigal P, Tzelepis K, Philippe C, Rattigan K, Asby R, Dembitz V, Magee ASM, Helgason G, Rouault-Pierre K, Vassiliou GS, Huntly BJP and Gallipoli P
Blood, American Society of Hematology vol. 138 (Supplement 1)
05-11-2021 - Ultrafast Photo-Crosslinking of Thiol–Norbornene Opaque Silicone Elastomer Nanocomposites in Air
Nguyen KDQ, Crespo-Ribadeneyra M, Picot O, Colak B and Gautrot JE
Acs Applied Polymer Materials, American Chemical Society
19-10-2021 - Quantitative Super-Resolution Imaging for the Analysis of GPCR Oligomerization
Joseph MD, Bort ET, Grose RP, McCormick PJ and Simoncelli S
Biomolecules, Mdpi vol. 11 (10)
12-10-2021 - 099 Ichthyosis associated with sphingosine 1-phosphate lyase deficiency is due to aberrant calcium and sphingolipid regulation
Smith CJ, Williams JL, Caley MP, O’Toole EA, Prasad R and Metherell LA
Journal of Investigative Dermatology vol. 141 (10), s165-s165.
07-10-2021 - Optogenetic modeling of human neuromuscular circuits in Duchenne muscular dystrophy with CRISPR and pharmacological corrections
Paredes-Redondo A, Harley P, Maniati E, Ryan D, Louzada S, Meng J, Kowala A, Fu B, Yang F, Liu P, Marino S, Pourquié O, Muntoni F, Wang J, Lieberam I and Lin YY
Science Advances vol. 7 (37)
10-09-2021 - Cx43 mediates changes in myofibroblast contraction and collagen release in human amniotic membrane defects after trauma
Costa E, Okesola BO, Thrasivoulou C, Becker DL, Deprest JA, David AL and Chowdhury TT
Scientific Reports, Springer Nature vol. 11 (1)
18-08-2021 - Expression of programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand (PD-L1) in adenocarcinomas of the gastroesophageal junction change significantly after neoadjuvant treatment
Jomrich G, Kollmann D, Ramazanova D, Ristl R, Grose RP, Ilhan-Mutlu A, Preusser M, Fassnacht C, Tsai Y-C, Guenova E and Schoppmann SF
European Journal of Surgical Oncology, Elsevier vol. 48 (2), 383-390.
11-08-2021 - Tuning Electrostatic Gating of Semiconducting Carbon Nanotubes by Controlling Protein Orientation in Biosensing Devices
Xu X, Bowen BJ, Gwyther REA, Freeley M, Grigorenko B, Nemukhin AV, Eklöf‐Österberg J, Moth‐Poulsen K, Jones DD and Palma M
Angewandte Chemie International Edition, Wiley vol. 60 (37), 20184-20189.
06-08-2021 - A Scarless Healing Tale: Comparing Homeostasis and Wound Healing of Oral Mucosa With Skin and Oesophagus
Pereira D and Sequeira I
Frontiers in Cell and Developmental Biology, Frontiers vol. 9
26-07-2021 - Tumour microenvironment 3D-modelling: simplicity to complexity and back again
Carter EP, Roozitalab R, Gibson SV and Grose RP
Trends in Cancer, Elsevier vol. 7 (11), 1033-1046.
24-07-2021 - Path selection of a train of spherical capsules in a branched microchannel
Lu RX, Wang Z, Salsac A-V, Barthès-Biesel D, Wang W and Sui Y
Journal of Fluid Mechanics, Cambridge University Press (Cup) vol. 923
22-07-2021 - Impact of the molecular structure of cationic binders on the rheological and adhesive properties of carboxymethyl cellulose-based coacervate hydrogels
Megone W, Tang P, Roohpour N and Gautrot JE
Arkivoc, Arkat Usa vol. 2021 (6), 101-119.
21-07-2021 - DNA-Directed Assembly of Carbon Nanotube–Protein Hybrids
Freeley M, Gwyther REA, Jones DD and Palma M
Biomolecules, Mdpi Ag
29-06-2021 - The Mechanical Interplay Between Differentiating Mesenchymal Stem Cells and Gelatin-Based Substrates Measured by Atomic Force Microscopy
Meng H, Chowdhury TT and Gavara N
Frontiers in Cell and Developmental Biology, Frontiers vol. 9
21-06-2021 - Cationic Polymer Brush-Coated Bioglass Nanoparticles for the Design of Bioresorbable RNA Delivery Vectors
Chang L, Yan H, Chang J and Gautrot JE
European Polymer Journal, Elsevier, 110593-110593.
13-06-2021 - Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype
Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR and Knight MM
Cancers, Mdpi vol. 13 (12)
10-06-2021 - Aortic pressure waveform reconstruction using a multi-channel Newton blind system identification algorithm
Liu W, Li Z, Wang Y, Song D, Ji N, Xu L, Mei T, Sun Y and Greenwald SE
Computers in Biology and Medicine, Elsevier vol. 135
08-06-2021 - A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion
Malacrida B, Nichols S, Maniati E, Jones R, Delanie-Smith R, Roozitalab R, Tyler EJ, Thomas M, Boot G, Mackerodt J, Lockley M, Knight MM, Balkwill FR and Pearce OMT
Iscience, Elsevier vol. 24 (6)
29-05-2021 - Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer
Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker LSM, Pearce OMT, Knight MM and Balkwill FR
Iscience, Elsevier vol. 24 (6)
29-05-2021 - Programmed death ligand 2 expression plays a limited role in adenocarcinomas of the gastroesophageal junction after preoperative chemotherapy
Jomrich G, Kollmann D, Wilfing L, Radosavljevic S, Ramazanova D, Ristl R, Grose RP, Ilhan-Mutlu A, Preusser M, Fassnacht C, Tsai Y-C, Guenova E and Schoppmann SF
European Surgery, Springer Nature vol. 53 (6), 287-293.
05-05-2021 - In Vitro Splicing Assay Proves the Pathogenicity of Intronic Variants in MRAP
Smith C, Maharaj AV, Qamar Y, Read J, Williams J, Chan L, Marimuthu V and Metherell L
Journal of The Endocrine Society vol. 5 (Suppl 1), a85-a86.
03-05-2021 - A novel capsule-based smell test fabricated via coaxial dripping
Ismail AS, Goodwin GR, Castrejon-Pita JR, Noyce AJ and Azevedo HS
Journal of The Royal Society Interface, The Royal Society vol. 18 (177)
28-04-2021 - Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling
Israeli H, Degtjarik O, Fierro F, Chunilal V, Gill AK, Roth NJ, Botta J, Prabahar V, Peleg Y, Chan LF, Ben-Zvi D, McCormick PJ, Niv MY and Shalev-Benami M
Science, American Association For The Advancement of Science (Aaas) vol. 372 (6544), 808-814.
15-04-2021 - Sub-toxic levels of cobalt ions impair mechanostranduction via HDAC6-depedent primary cilia shortening.
Wu H, Wang Z, Liu S, Meng H, Shelton JC, Thompson CL, Fu S and Knight MM
Biochem Biophys Res Commun
15-04-2021 - Dissecting FGF Signalling to Target Cellular Crosstalk in Pancreatic Cancer
Carter EP, Coetzee AS, Tomas Bort E, Wang Q, Kocher HM and Grose RP
Cells, Mdpi vol. 10 (4)
08-04-2021 - Alpha‐1‐antitrypsin reduces inflammation and exerts chondroprotection in arthritis
Kaneva MK, Muley MM, Krustev E, Reid AR, Souza PR, Dell’Accio F, McDougall JJ and Perretti M
The Faseb Journal, Wiley vol. 35 (5)
31-03-2021 - Extreme reversal in mechanical anisotropy in liquid-liquid interfaces reinforced with self-assembled protein nanosheets
Megone W, Kong D, Peng L and Gautrot JE
Journal of Colloid and Interface Science, Elsevier vol. 594, 650-657.
17-03-2021 - Photoelectrochemical imaging system with high spatiotemporal resolution for visualizing dynamic cellular responses
Zhou B, Das A, Zhong M, Guo Q, Zhang D-W, Hing KA, Sobrido AJ, Titirici M-M and Krause S
Biosensors and Bioelectronics, Elsevier vol. 180
02-03-2021 - Corrigendum: Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models
Thompson CL, Fu S, Heywood HK, Knight MM and Thorpe SD
Frontiers in Bioengineering and Biotechnology, Frontiers vol. 9
18-02-2021 - Precise positioning of enzymes within hierarchical polymer nanostructures for switchable bioelectrocatalysis.
Qu F, Ma X and Gautrot JE
Biosensors and Bioelectronics, Elsevier vol. 179, 113045-113045.
18-02-2021 - Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption
Adams SD, Csere J, D’angelo G, Carter EP, Romao M, Arnandis T, Dodel M, Kocher HM, Grose R, Raposo G, Mardakheh F and Godinho SA
Current Biology, Elsevier vol. 31 (7), 1403-1416.e7.
15-02-2021 - Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer
Delaine-Smith R, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones R, Lecker L, Pearce O, Knight M and Balkwill F
, Editors: Balkwill F. Biorxiv.Org
02-02-2021 - The keratin network of intermediate filaments regulates keratinocyte rigidity sensing and nuclear mechanotransduction
Laly AC, Sliogeryte K, Pundel OJ, Ross R, Keeling MC, Avisetti D, Waseem A, Gavara N and Connelly JT
Science Advances, American Association For The Advancement of Science (Aaas) vol. 7 (5)
27-01-2021 - Comparative Adhesion of Chemically and Physically Crosslinked Poly(Acrylic Acid)-Based Hydrogels to Soft Tissues
Cozens EJ, Roohpour N and Gautrot JE
European Polymer Journal, Elsevier, 110250-110250.
18-01-2021 - Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction
Fu S, Meng H, Inamdar S, Das B, Gupta H, Wang W, Thompson C and Knight M
, Editors: Block JA. Osteoarthritis and Cartilage, Elsevier
01-01-2021 - Hallmarks of cancer—the new testament
Senga SS and Grose RP
Open Biology, The Royal Society vol. 11 (1)
01-01-2021 - A high-throughput method to characterize membrane viscosity of flowing microcapsules
Lin T, Wang Z, Lu R, Wang W and Sui Y
Physics of Fluids, Aip Publishing vol. 33 (1)
01-01-2021 - A neural network-based algorithm for high-throughput characterisation of viscoelastic properties of flowing microcapsules
Lin T, Wang Z, Wang W and Sui Y
Soft Matter, Royal Society of Chemistry (Rsc) vol. 17 (15), 4027-4039.
01-01-2021 - Chapter 11 Recent Advances in the Design of Surface-initiated Polymer Brushes for Biomedical Applications
Qu F, Raynold AM and Gautrot JE
In Soft Matter For Biomedical Applications, Royal Society of Chemistry (Rsc) 264-300.
01-01-2021