Publications
The following journal papers published by the members of the CPM, specifically relate to the development and/or use of predictive in vitro models.
- Photoelectrochemical imaging of single cardiomyocytes and monitoring of their action potentials through contact force manipulation of organoids
Jacques R, Zhou B, Marhuenda E, Gorecki J, Das A, Iskratsch T and Krause S
Biosensors and Bioelectronics, Elsevier
21-12-2022 - Current Understanding of the Role of Senescent Melanocytes in Skin Ageing
Bishop C
Biomedicines, Mdpi vol. 10 (12), 3111-3111.
02-12-2022 - 181 Sphingosine 1-phosphate lyase insufficiency induced ichthyosis is due to sphingolipid imbalance, increased differentiation, and aberrant intercellular junctions
Smith CJ, Williams JL, Hall C, Caley MP, O’Toole EA, Prasad R and Metherell LA
Journal of Investigative Dermatology, Elsevier vol. 142 (12)
01-12-2022 - Regulation of Cardiomyocyte Adhesion and
Mechanosignalling Through Distinct Nanoscale Behaviour of
Integrin Ligands Mimicking Healthy or Fibrotic ECM
Iskratsch T, Hawkes W, Marhuenda E, Reynolds P, O'Neill C, PANDEY P, Wilson D, FREELEY M, HUANG D, Junquiang H, Gondarenko S, Hone J, Gadegaard N and Palma M
Philosophical Transactions of The Royal Society B: Biological Sciences, The Royal Society
21-11-2022 - Organ-on-a-Chip Technologies Network special issue editorial
Biddle A
In Vitro Models, Springer Nature vol. 1 (6), 397-398.
17-11-2022 - Inhibition of Stearoyl-CoA Desaturase Has Anti-Leukemic Properties in Acute Myeloid Leukemia
Dembitz V, Lawson H, Philippe C, Burt RJ, James S, Magee ASM, Woodley K, Durko J, Campos J, Austin MJ, Rio-Machin A, Izquierdo PC, Bewicke-Copley F, Blanco GR, Patel B, Hazlehurst L, Peck B, Finch A, Cutillas P, Fitzgibbon J, Yuneva M, Rouault-Pierre K, Copland J, Kranc K and Gallipoli P
Blood, American Society of Hematology vol. 140 (Supplement 1), 3058-3060.
15-11-2022 - Nuclear FGFR1 promotes pancreatic stellate cell-driven invasion through up-regulation of Neuregulin 1
Coetzee AS, Carter EP, Rodríguez-Fernández L, Heward J, Wang Q, Karim SA, Boughetane L, Milton C, Uyulur F, Morton JP, Kocher HM and Grose RP
Oncogene, Springer Nature vol. 42 (7), 491-500.
10-11-2022 - CRISPR-mediated correction of skeletal muscle Ca2+ handling in a novel DMD patient-derived pluripotent stem cell model
Morera C, Kim J, Paredes-Redondo A, Nobles M, Rybin D, Moccia R, Kowala A, Meng J, Garren S, Liu P, Morgan JE, Muntoni F, Christoforou N, Owens J, Tinker A and Lin Y-Y
Neuromuscular Disorders
01-11-2022 - Diabetes and obesity in down syndrome across the lifespan: a retrospective cohort study using UK electronic health records
Aslam A, Baksh A, Pape S, Consortium G-D, Strydom A, Gulliford M and Chan L
Endocrine Abstracts, Bioscientifica
17-10-2022 - The Architecture of Oligonucleotide-Polycationic Brush Complexes – A Neutron Reflectometry Study
Gautrot JE, Chang L, Alexis C, Gutfreund P and Zarbakhsh A
Advanced Materials Interfaces, Wiley
13-10-2022 - In vivo labelling system to study cell neighbourhoods
Ombrato L
Nature Reviews Cancer, Springer Nature vol. 22 (12), 661-661.
29-09-2022 - A Roadmap for the Human Oral and Craniofacial Cell Atlas
Caetano AJ, Caetano A, Sharpe P, Volponi AA, Yianni V, Bush M, McKay LK, Wallet S, Shazib MA, Kimple A, Byrd KM, Easter Q, Weaver T, Sequeira I, Kumar R, Pereira D, Macken J, Fortune F, Efremova M, Teichmann S, Kretzschmar K, Todres E, Boffelli D, Hagood JS, Klein O, Boucher R, Lwin S, Pranzatelli T, Beachy P and Lu WJ
Journal of Dental Research, Sage Publications vol. 101 (11), 1274-1288.
26-09-2022 - Mechanostimulation of breast myoepithelial cells induces functional changes associated with DCIS progression to invasion
Hayward M-K, Allen MD, Gomm JJ, Goulding I, Thompson CL, Knight MM, Marshall JF and Jones JL
Npj Breast Cancer, Springer Nature vol. 8 (1)
20-09-2022 - Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems
Heywood HK, Gardner L, Knight MM and Lee DA
In Vitro Models, Springer Nature, 1-8.
31-08-2022 - Single molecule DNA origami nanoarrays with controlled protein orientation
Cervantes-Salguero K, Freeley M, Gwyther REA, Jones DD, Chávez JL and Palma M
Biophysics Reviews, Aip Publishing vol. 3 (3)
18-08-2022 - Acoustically accelerated neural differentiation of human embryonic stem cells
Sun C, Dong Y, Wei J, Cai M, Liang D, Fu Y, Zhou Y, Sui Y, Wu F, Mikhaylov R, Wang H, Fan F, Xie Z, Stringer M, Yang Z, Wu Z, Tian L and Yang X
Acta Biomaterialia, Elsevier vol. 151, 333-345.
29-07-2022 - Design of an Integrated Microvascularized Human Skin-on-a-Chip Tissue Equivalent Model
Jones CFE, Di Cio S, Connelly JT and Gautrot JE
Frontiers in Bioengineering and Biotechnology, Frontiers Media vol. 10
19-07-2022 - FRI198 Investigating the function of Endothelial-To-Mesenchymal transition during liver fibrogenesis using a Liver-On-A-Chip platform
Whiteford J, Arokiasamy S, Thompson C, Alazawi W and Dufton N
Journal of Hepatology, Elsevier vol. 77
01-07-2022 - Highlight: microfluidic devices for cancer metastasis studies
Scemama A, Lunetto S and Biddle A
In Vitro Models, Springer Nature vol. 1 (6), 399-403.
27-06-2022 - Multi-Scale Analysis of the Composition, Structure, and Function of Decellularized Extracellular Matrix for Human Skin and Wound Healing Models
Sarmin AM, Moussaid NE, Suntornnond R, Tyler EJ, Kim Y-H, Di Cio S, Megone WV, Pearce O, Gautrot JE, Dawson J and Connelly JT
Biomolecules, Mdpi vol. 12 (6)
16-06-2022 - Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial
Rivellese F, Surace AEA, Goldmann K, Sciacca E, Çubuk C, Giorli G, John CR, Nerviani A, Fossati-Jimack L, Thorborn G, Ahmed M, Prediletto E, Church SE, Hudson BM, Warren SE, McKeigue PM, Humby F, Bombardieri M, Barnes MR, Lewis MJ and Pitzalis C
Nature Medicine, Springer Nature vol. 28 (6), 1256-1268.
19-05-2022 - Senescence-associated morphological profiles (SAMPs): an image-based phenotypic profiling method for evaluating the inter and intra model heterogeneity of senescence
Wallis R, Milligan D, Hughes B, Mizen H, López-Domínguez JA, Eduputa U, Tyler EJ, Serrano M and Bishop CL
Aging, Impact Journals vol. 14 (10), 4220-4246.
16-05-2022 - Single‐cell sequencing reveals the heterogeneity and intratumoral crosstalk in human endometrial cancer
Yu Z, Zhang J, Zhang Q, Wei S, Shi R, Zhao R, An L, Grose R, Feng D and Wang H
Cell Proliferation, Wiley vol. 55 (6)
13-05-2022 - Protein Ligand Nanopattern Size Selects for Cellular Adhesion via Hemidesmosomes over Focal Adhesions
Ghorbani S, Shahrokhtash A, Gautrot JE and Sutherland DS
Small Methods, Wiley vol. 6 (6)
22-04-2022 - Organ-on-a-chip: current gaps and future directions
Candarlioglu PL, Dal Negro G, Hughes D, Balkwill F, Harris K, Screen H, Morgan H, David R, Beken S, Guenat O, Rowan W and Amour A
Biochemical Society Transactions, Portland Press vol. 50 (2), 665-673.
19-04-2022 - Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching
Swiatlowska P, Sit BHM, Zhen F, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones G, Yu C-H and Iskratsch T
Science Advances, American Association For The Advancement of Science
15-04-2022 - Impact of the multiscale viscoelasticity of quasi-2D self-assembled protein networks on stem cell expansion at liquid interfaces
Kong D, Peng L, Bosch-Fortea M, Chrysanthou A, Alexis CVJM, Matellan C, Zarbakhsh A, Mastroianni G, del Rio Hernandez A and Gautrot JE
Biomaterials, Elsevier vol. 284
06-04-2022 - Estimation of central pulse wave velocity from radial pulse wave analysis
Yao Y, Zhou S, Alastruey J, Hao L, Greenwald SE, Zhang Y and Xu L
Computer Methods and Programs in Biomedicine, Elsevier vol. 219
27-03-2022 - Improving the accuracy and robustness of carotid-femoral pulse wave velocity measurement using a simplified tube-load model
Xu L, Zhou S, Wang L, Yao Y, Hao L, Qi L, Han H, Mukkamala R and Greenwald SE
Scientific Reports, Springer Nature vol. 12 (1)
25-03-2022 - Noninvasive estimation of aortic pressure waveform based on simplified Kalman filter and dual peripheral artery pressure waveforms
Liu W, Du S, Zhou S, Mei T, Zhang Y, Sun G, Song S, Xu L, Yao Y and Greenwald SE
Computer Methods and Programs in Biomedicine, Elsevier vol. 219
17-03-2022 - Assessing the Role of Carbonyl Adducts, Particularly Malondialdehyde Adducts, in the Development of Dermis Yellowing Occurring during Skin Photoaging
Zucchi H, Pageon H, Asselineau D, Ghibaudo M, Sequeira I and Girardeau-Hubert S
Life, Mdpi vol. 12 (3)
10-03-2022 - Highly Stretchable Conductive Covalent Coacervate Gels for Electronic Skin
Nguyen NT, Jennings J, Milani AH, Martino CDS, Nguyen LTB, Wu S, Mokhtar MZ, Saunders JM, Gautrot JE, Armes SP and Saunders BR
Biomacromolecules, American Chemical Society (Acs) vol. 23 (3), 1423-1432.
21-02-2022 - Extracellular Adhesive Cues Physically Define Nucleolar Structure and Function
Pundel OJ, Blowes LM and Connelly JT
Advanced Science, Wiley vol. 9 (10)
05-02-2022 - Numerical and theoretical analysis of fast evaporating sessile droplets with coupled fields
Shen Y, Kang F, Cheng Y, Zhang K and Sui Y
International Journal of Thermal Sciences, Elsevier vol. 172
01-02-2022 - Detection and Localization of Myocardial Infarction Based on Multi-Scale ResNet and Attention Mechanism
Cao Y, Liu W, Zhang S, Xu L, Zhu B, Cui H, Geng N, Han H and Greenwald SE
Frontiers in Physiology, Frontiers vol. 13
28-01-2022 - The Obscure Potential of AHNAK2
Zardab M, Stasinos K, Grose RP and Kocher HM
Cancers, Mdpi vol. 14 (3)
21-01-2022 - Building in vitro 3D human multicellular models of high-grade serous ovarian cancer
Malacrida B, Pearce OMT and Balkwill FR
Star Protocols, Elsevier vol. 3 (1)
11-01-2022 - FGF signalling facilitates cervical cancer progression
Mahmood HTNA, Tomas Bort E, Walker AJ, Grose RP and Chioni AM
The Federation of European Biochemical Societies (Febs) Journal, Wiley
03-01-2022 - Characterising Mechanical Properties of Flowing Microcapsules Using a Deep Convolutional Neural Network
T. Lin TL, Z. Wang ZW, R. X. Lu RXL, W. Wang WW and Y. Sui YS
Advances in Applied Mathematics and Mechanics, Global Science Press vol. 14 (1), 79-100.
01-01-2022 - Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion
Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A, Marshall JJT, Rosewell I, Tatari M, Rajeeve V, Khan F, Wang J, Kotantaki P, Tyler EJ, Singh N, Reader CS, Carter EP, Hodivala-Dilke K, Grose RP, Kocher HM, Gavara N, Pearce O, Cutillas P, Marshall JF and Cameron AJM
Cell Reports, Elsevier vol. 38 (4)
01-01-2022 - Novel application of live imaging to determine the functional cell biology of endothelial-to-mesenchymal transition (EndMT) within a liver-on-a-chip platform
Whiteford J, Arokiasamy S, Thompson CL and Dufton NP
In Vitro Models, Springer Nature vol. 1 (6), 413-421.
01-01-2022