Publications
The following journal papers published by the members of the CPM, specifically relate to the development and/or use of predictive in vitro models.
- A Novel Primary Cilium‐Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells
Verbruggen SW, Nolan J, Duffy MP, Pearce OMT, Jacobs CR and Knight MM
Advanced Science, Wiley vol. 11 (2), 2305842-2305842.
15-11-2023 - CD73 controls Myosin II–driven invasion, metastasis, and immunosuppression in amoeboid pancreatic cancer cells
Samain R, Maiques O, Monger J, Lam H, Candido J, George S, Ferrari N, KohIhammer L, Lunetto S, Varela A, Orgaz JL, Vilardell F, Olsina JJ, Matias-Guiu X, Sarker D, Biddle A, Balkwill FR, Eyles J, Wilkinson RW, Kocher HM, Calvo F, Wells CM and Sanz-Moreno V
Science Advances, American Association For The Advancement of Science (Aaas) vol. 9 (42)
18-10-2023 - Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment
Thompson CL, Hopkins T, Bevan C, Screen HRC, Wright KT and Knight MM
Biomedical Materials, Iop Publishing vol. 18 (6)
10-10-2023 - Cx43 regulates mechanotransduction mechanisms in human preterm amniotic membrane defects
Costa E, Thrasivoulou C, Becker DL, Deprest JA, David AL and Chowdhury TT
Prenatal Diagnosis, Wiley
30-08-2023 - The Future of Precision Oncology
Rulten SL, Grose RP, Gatz SA, Jones JL and Cameron AJM
International Journal of Molecular Sciences, Mdpi vol. 24 (16)
09-08-2023 - Nonaffine Mechanics of Entangled Networks Inspired by Intermediate Filaments
Pensalfini M, Golde T, Trepat X and Arroyo M
Physical Review Letters, American Physical Society (Aps) vol. 131 (5)
04-08-2023 - Core–Shell-Structured Electrorheological Fluid with a Polarizability-Tunable Nanocarbon Shell for Enhanced Stimuli-Responsive Activity
Chen S, Cheng Y, Zhao Z, Zhang K, Hao T, Sui Y, Wang W, Zhao J and Li Y
Acs Applied Materials & Interfaces, American Chemical Society (Acs) vol. 15 (29), 35741-35749.
14-07-2023 - ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradation
Gibson SV, Madzharova E, Tan AC, Allen MD, Keller UAD, Jones JL, Carter EP and Grose RP
Matrix Biology, Elsevier vol. 121, 74-89.
17-06-2023 - The gut microbe‐derived methylamine TMAO protects against neuroinflammation through restraint of pro‐inflammatory glial behaviour
McArthur S
Alzheimer's & Dementia, Wiley vol. 19 (S1)
16-06-2023 - A guide to functionalisation and bioconjugation strategies to surface-initiated polymer brushes
Neri-Cruz CE, Teixeira FME and Gautrot JE
Chemical Communications, Royal Society of Chemistry vol. 59 (49), 7534-7558.
09-05-2023 - Transient deformation of a viscoelastic capsule in a cross-slot microchannel: effects of inertia and membrane viscosity
Lu RX, Guo ZY, Yu P and Sui Y
Journal of Fluid Mechanics, Cambridge University Press (Cup) vol. 962
03-05-2023 - 769 Reduced expression of PPOX, the variegate porphyria gene, causes intrinsic pathological changes to keratinocytes
Smith CJ, Chan L and Metherell LA
Journal of Investigative Dermatology, Elsevier vol. 143 (5)
01-05-2023 - Multiple morbidity across the lifespan in people with Down syndrome or intellectual disabilities: a population-based cohort study using electronic health records
Baksh RA, Pape SE, Chan LF, Aslam AA, Gulliford MC, Strydom A and Consortium G-D
The Lancet Public Health, Elsevier vol. 8 (6), e453-e462.
26-04-2023 - Development of an in vitro microfluidic model to study the role of microenvironmental cells in oral cancer metastasis
Scemama A, Tailor A, Di Cio S, Dibble M, Gautrot J and Biddle A
F1000research, Taylor and Francis vol. 12, 439-439.
25-04-2023 - Programmed Self-Assembly of DNA Nanosheets with Discrete Single-Molecule Thickness and Interfacial Mechanics: Design, Simulation, and Characterization.
Cervantes-Salguero K, Gutiérrez Fosado YA, Megone W, Gautrot JE and Palma M
Molecules, Mdpi vol. 28 (9)
24-04-2023 - The impact of pericytes on the stability of microvascular networks in response to nanoparticles
Dibble M, Di Cio’ S, Luo P, Balkwill F and Gautrot JE
Scientific Reports, Springer Nature vol. 13 (1)
07-04-2023 - Abstract 4576: 3D in vitro models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancer
Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Garrobo-Calleja I, Gautrot J and Balkwill F
Cancer Research, American Association For Cancer Research (Aacr) vol. 83 (7_Supplement), 4576-4576.
04-04-2023 - HDAC Inhibition Restores Response to HER2-Targeted Therapy in Breast Cancer via PHLDA1 Induction
Clayton NS, Carter EP, Fearon AE, Heward JA, Fernández LR, Boughetane L, Wilkes EH, Cutillas PR and Grose RP
International Journal of Molecular Sciences, Mdpi vol. 24 (7)
25-03-2023 - A method for real-time mechanical characterisation of microcapsules
Guo Z, Lin T, Jing D, Wang W and Sui Y
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 22 (4), 1209-1220.
24-03-2023 - Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
Bort ET, Joseph MD, Wang Q, Carter EP, Roth NJ, Gibson J, Samadi A, Kocher HM, Simoncelli S, McCormick PJ and Grose RP
Elife, Elife vol. 12
21-03-2023 - Growth of mesenchymal stem cells at the surface of silicone, mineral and plant-based oils
Peng L, Nadal C and Gautrot JE
Biomedical Materials, Iop Publishing vol. 18 (3)
17-03-2023 - Mechano-biological and bio-mechanical pathways in cutaneous wound healing
Pensalfini M and Tepole AB
Plos Computational Biology, Public Library of Science (Plos) vol. 19 (3)
09-03-2023 - 3D Compartmentalised Human Pluripotent Stem Cell–derived Neuromuscular Co-cultures
Harley P, Paredes-Redondo A, Grenci G, Viasnoff V, Lin Y-Y and Lieberam I
Bio-Protocol vol. 13 (5), e4624-e4624.
05-03-2023 - TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression
Gibson SV, Tomas Bort E, Rodríguez-Fernández L, Allen MD, Gomm JJ, Goulding I, auf dem Keller U, Agnoletto A, Brisken C, Peck B, Cameron AJ, Marshall JF, Jones JL, Carter EP and Grose RP
Npj Breast Cancer, Springer Nature vol. 9 (1)
02-03-2023 - Ichthyosis linked to sphingosine 1-phosphate lyase insufficiency is due to aberrant sphingolipid and calcium regulation
Smith CJ, Williams JL, Hall C, Casas J, Caley MP, O'Toole EA, Prasad R and Metherell LA
Journal of Lipid Research, Elsevier vol. 64 (4)
02-03-2023 - A computational model for the transit of a cancer cell through a constricted microchannel
Wang Z, Lu R, Wang W, Tian FB, Feng JJ and Sui Y
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 22 (4), 1129-1143.
28-02-2023 - Mesenchymal Stem Cells Sense the Toughness of Nanomaterials and Interfaces
Peng L, Matellan C, Bosch‐Fortea M, Gonzalez‐Molina J, Frigerio M, Salentinig S, del Rio Hernandez A and Gautrot JE
Advanced Healthcare Materials, Wiley vol. 12 (13)
21-02-2023 - Everybody needs good neighbours: the progressive DCIS microenvironment
Gibson SV, Roozitalab RM, Allen MD, Jones JL, Carter EP and Grose RP
Trends in Cancer, Elsevier vol. 9 (4), 326-338.
02-02-2023 - Low HER2 enables dedifferentiation and transformation of normal breast epithelial cells via chromatin opening
Hayat A, Carter EP, King HW, Ors A, Doe A, Teijeiro SA, Charrot S, Godinho S, Cutillas P, Mohammed H, Grose RP and Ficz G
Disease Models & Mechanisms, The Company of Biologists vol. 16 (2)
01-02-2023 - Mechanical Evaluation of Hydrogel–Elastomer Interfaces Generated through Thiol–Ene Coupling
Nguyen KDQ, Dejean S, Nottelet B and Gautrot JE
Acs Applied Polymer Materials, American Chemical Society (Acs) vol. 5 (2), 1364-1373.
30-01-2023 - Co-Surfactant-Free Bioactive Protein Nanosheets for the Stabilization of Bioemulsions Enabling Adherent Cell Expansion
Chrysanthou A, Bosch-Fortea M and Gautrot JE
Biomacromolecules, American Chemical Society (Acs) vol. 24 (10), 4465-4477.
23-01-2023 - Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK
Nolan J, Pearce OMT, Screen HRC, Knight MM and Verbruggen SW
Cancers, Mdpi vol. 15 (3)
19-01-2023 - Supercharged Protein Nanosheets for Cell Expansion on Bioemulsions
Chrysanthou A, Kanso H, Zhong W, Shang L and Gautrot JE
Acs Applied Materials & Interfaces, American Chemical Society (Acs) vol. 15 (2), 2760-2770.
04-01-2023 - A host-gut microbial amino acid co-metabolite, p-cresol glucuronide, promotes blood-brain barrier integrity in vivo.
Stachulski AV, Knausenberger TB-A, Shah SN, Hoyles L and McArthur S
Tissue Barriers vol. 11 (1), 2073175-2073175.
02-01-2023 - Three-dimensional numerical analysis of wall stress induced by asymmetric oscillation of microbubble trains inside micro-vessels
Ri J, Pang N, Bai S, Xu J, Xu L, Ri S, Yao Y and Greenwald SE
Physics of Fluids, Aip Publishing vol. 35 (1)
01-01-2023 - Machine learning and disease prediction in obstetrics
Arain Z, Iliodromiti S, Slabaugh G, David AL and Chowdhury TT
Current Research in Physiology, Elsevier vol. 6
01-01-2023 - In silico targeting of colony-stimulating factor-1 receptor: delineating immunotherapy in cancer
Azhar Z, Grose RP, Raza A and Raza Z
Exploration of Targeted Anti-Tumor Therapy, Open Exploration Publishing vol. 4 (4), 727-742.
01-01-2023