Dr Jianmin Chen

Jianmin Chen

Lecturer in Inflammation and Cardiovascular Medicine; Versus Arthritis Career Development Fellow

William Harvey Research Institute
Queen Mary University of London
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Research

Cardiomyopathy, HFpEF, Rheumatoid arthritis, Immune cells, Metabolism, Inflammation

Cardiovascular Models, Musculoskeletal Models

Interests

I am interested to study the switching of phenotypes and alterations in phagocytosis activity of macrophages upon pharmaceutical treatments in vitro. This assay can be conducted with biogel-elicited macrophages or bone marrow-derived macrophages. Phenotypes and phagocytosis activity of macrophages can be determined by flow cytometry. I have also developed techniques to look at mitochondrial mass and potential from isolated primary cardiomyocytes, immune cells, cardiac fibroblasts and endothelial cells using flow cytometry.

Publications

Publications of specific relevance to Predictive in vitro Models

2023

Chen J, Oggero S, Cecconello C, Dalli J, Hayat H, Hjiej Andaloussi A, Sanni S, Jonassen TE and Perretti M (2023). The Annexin-A1 mimetic RTP-026 promotes acute cardioprotection through modulation of immune cell activation. Elsevier  Pharmacological Research  vol. 198,  
Chen J, Austin-Williams S, O'Riordan CE, Claria-Ribas P, Sugimoto MA, Norling LV, Thiemermann C and Perretti M (2023). Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction. Karger Publishers  Journal of Innate Immunity  vol. 15, (1) 548-561.  

2022

Costa VV, Sugimoto MA, Hubner J, Bonilha CS, Queiroz-Junior CM, Gonçalves-Pereira MH, Chen J, Gobbetti T, Rodrigues GOL, Bambirra JL, Passos IB, Lopes CEM, Moreira TP, Bonjour K, Melo RC, Oliveira MA, Andrade MVM, Sousa LP, Souza DG, da Costa Santiago H, Perretti M and Teixeira MM (2022). Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease. Elife  Elife  vol. 11,  
Hamers A, Primus CP, Whitear C, Kumar NA, Masucci M, Moreira SAM, Rathod K, Chen J, Bubb K, Colas R, Khambata RS, Dalli J and Ahluwalia A (2022). 20‐hydroxyeicosatetraenoic acid (20‐HETE) is a pivotal endogenous ligand for TRPV1‐mediated neurogenic inflammation in the skin. Wiley  British Journal of Pharmacology  vol. 179, (7) 1450-1469.  

2021

Gee LC, Massimo G, Lau C, Primus C, Fernandes D, Chen J, Rathod KS, Hamers AJP, Filomena F, Nuredini G, Ibrahim AS, Khambata RS, Gupta AK, Moon JC, Kapil V and Ahluwalia A (2021). Inorganic nitrate attenuates cardiac dysfunction: roles for xanthine oxidoreductase and nitric oxide. Wiley  British Journal of Pharmacology  vol. 179, (20) 4757-4777.  
Chen J, Norling LV, Mesa JG, Silva MDP, Burton SE, Reutelingsperger C, Perretti M and Cooper D (2021). Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis. Proceedings of The National Academy of Sciences  Proceedings of The National Academy of Sciences of The United States of America  vol. 118, (38)  
de Gaetano M, Tighe C, Gahan K, Zanetti A, Chen J, Newson J, Cacace A, Marai M, Gaffney A, Brennan E, Kantharidis P, Cooper ME, Leroy X, Perretti M, Gilroy D, Godson C and Guiry PJ (2021). Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A4 Mimetics (QNX-sLXms). American Chemical Society (Acs)  Journal of Medicinal Chemistry  vol. 64, (13) 9193-9216.  

2020

Chen J, Purvis GSD, Collotta D, Zoubi SA, Sugimoto MA, Cacace A, Martin L, Colas RA, Collino M, Dalli J and Thiemermann C (2020). RvE1 Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction and Enhances Bacterial Clearance. Frontiers Media  Frontiers in Immunology  vol. 11, 2080-2080.  
Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S, Hobbs AJ, Thiemermann C and Tinker A (2020). Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia. Springer Science and Business Media Llc  Journal of Molecular Medicine   
Kieswich JE, Chen J, Alliouachene S, Caton PW, McCafferty K, Thiemermann C and Yaqoob MM (2020). Immunohistochemistry of Kidney a-SMA, Collagen 1, and Collagen 3, in A Novel Mouse Model of Reno-cardiac Syndrome. Bio-Protocol  Bio-Protocol  vol. 10, (18)  

2019

Yun Y, Chen J, Liu R, Chen W, Liu C, Wang R, Hou Z, Yu Z, Sun Y, IJzerman AP, Heitman LH, Yin X and Guo D (2019). Long residence time adenosine A1 receptor agonists produce sustained wash-resistant antilipolytic effect in rat adipocytes. Elsevier  Biochemical Pharmacology  vol. 164, 45-52.  

2018

Zoubi SA, Chen J, Murphy C, Martin L, Chiazza F, Collotta D, Yaqoob MM, Collino M and Thiemermann C (2018). Linagliptin Attenuates the Cardiac Dysfunction Associated With Experimental Sepsis in Mice With Pre-existing Type 2 Diabetes by Inhibiting NF-κB. Frontiers  Frontiers in Immunology  vol. 9,  
Kieswich JE, Chen J, Alliouachene S, Caton PW, McCafferty K, Thiemermann C and Yaqoob MM (2018). A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain. Springer Nature  Bmc Nephrology  vol. 19, (1)  
de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E, Maingot C, McLoughlin A, Brennan E, Leroy X, Loscher CE, Fallon P, Perretti M, Godson C and Guiry PJ (2018). Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms). Elsevier  European Journal of Medicinal Chemistry  vol. 162, 80-108.  
Chen J, Hamers AJP, Finsterbusch M, Massimo G, Zafar M, Corder R, Colas RA, Dalli J, Thiemermann C and Ahluwalia A (2018). Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis. Faseb J  fj201701303-fj201701303.  
Khan AI, Kapoor A, Chen J, Martin L, Rogazzo M, Mercier T, Decosterd L, Collino M and Thiemermann C (2018). The Antimalarial Drug Artesunate Attenuates Cardiac Injury in A Rodent Model of Myocardial Infarction. Shock  vol. 49, (6) 675-681.  

2017

Purvis GSD, Chiazza F, Chen J, Loiola RA, Martin L, Fountoulakis N, Gnudi L, Collino M, Thiemermann C and Solito E (2017). Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes. Springer Verlag  Diabetologia   
Johnson FL, Patel NSA, Purvis GSD, Chiazza F, Chen J, Sordi R, Hache G, Merezhko VV, Collino M, Yaqoob MM and Thiemermann C (2017). Inhibition of IκB Kinase at 24 Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis. J Am Heart Assoc  vol. 6, (7)  
Martin L, Gombert A, Chen J, Liebens J, Verleger J, Kalder J, Marx G, Jacobs M, Thiemermann C and Schuerholz T (2017). The β-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men. Frontiers Media  Front Immunol  vol. 8, 681-681.  

2016

Chen J and Thiemermann C (2016). Selenium and Niacin for Sepsis Therapy. Wolters Kluwer  Critical Care Medicine  vol. 44, (6) 1256-1257.  
Chen J, Kieswich J, Chiazza F, Moyes A, Gobbetti T, Purvis G, Salvatori D, Patel N, Perretti M, Hobbs A, Collino M, Yaqoob M and THIEMERMANN C (2016). IkB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD. American Society of Nephrology  Journal of The American Society of Nephrology   
Zhang W, Zhao X, Xiao Y, Chen J, Han P, Zhang J, Fu H and Kang YJ (2016). The association of depressed angiogenic factors with reduced capillary density in the Rhesus monkey model of myocardial ischemia. Oxford University Press (Oup)  Metallomics  vol. 8, (7) 654-662.  

2014

Gobbetti T, Coldewey SM, Chen J, McArthur S, le Faouder P, Cenac N, Flower RJ, Thiemermann C and Perretti M (2014). Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proceedings of The National Academy of Sciences  Proceedings of The National Academy of Sciences of The United States of America  vol. 111, (52) 18685-18690.  
Chen J, Chiazza F, Collino M, Patel NSA, Coldewey SM and Thiemermann C (2014). Gender Dimorphism of the Cardiac Dysfunction in Murine Sepsis: Signalling Mechanisms and Age-Dependency. Public Library of Science (Plos)  Plos One  vol. 9, (6)  

2013

Sun X, Cai J, Fan X, Han P, Xie Y, Chen J, Xiao Y and Kang YJ (2013). Decreases in Electrocardiographic R-Wave Amplitude and QT Interval Predict Myocardial Ischemic Infarction in Rhesus Monkeys with Left Anterior Descending Artery Ligation. Public Library of Science (Plos)  Plos One  vol. 8, (8)  

2012

Xie Y, Chen J, Han P, Yang P, Hou J and Kang YJ (2012). Immunohistochemical detection of differentially localized up-regulation of lysyl oxidase and down-regulation of matrix metalloproteinase-1 in rhesus monkey model of chronic myocardial infarction. Frontiers  Experimental Biology and Medicine  vol. 237, (7) 853-859.  

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconBlood analysis protocol: Efficacy of RTP026 in MI patients
Mauro Perretti, Jianmin Chen and Sharmilee Gnanapavan
£261,605 WHRL William Harvey Research Limited (01-09-2024 - 28-02-2027)