Dr Yung-Yao Lin

Yung-Yao Lin

Senior Lecturer

Centre for Genomics and Child Health, Blizard Institute
Faculty of Medicine and Dentistry, Queen Mary University of London
ORCID LinkedIn X

Research

Human induced pluripotent stem cells, CRISPR genome editing, Neuromuscular disorders, Disease modelling, Regenerative medicine, Tissue engineering

Underpinning Bioengineering, Cardiovascular Models, Infectious Disease and Inflammation Models, Musculoskeletal Models, Neuronal Models

Interests

Research in the Lin group is focused on muscular dystrophy and mechanisms regulating muscle regeneration. His work has brought novel insights into the pathological mechanisms underlying some types of muscular dystrophy. The Lin group has established essential expertise in generation and differentiation of human induced pluripotent stem cells (iPSCs) and CRISPR-mediated genome manipulation technology. We are interested in integrating human iPSC and Organ-on-a-Chip technologies to enable neuromuscular research in health and disease, as well as drug discovery.

Publications

Publications of specific relevance to Predictive in vitro Models

2023

Harley P, Paredes-Redondo A, Grenci G, Viasnoff V, Lin Y-Y and Lieberam I (2023). 3D Compartmentalised Human Pluripotent Stem Cell–derived Neuromuscular Co-cultures. Bio-Protocol  vol. 13, (5) e4624-e4624.  

2022

Morera C, Kim J, Paredes-Redondo A, Nobles M, Rybin D, Moccia R, Kowala A, Meng J, Garren S, Liu P, Morgan JE, Muntoni F, Christoforou N, Owens J, Tinker A and Lin Y-Y (2022). CRISPR-mediated correction of skeletal muscle Ca2+ handling in a novel DMD patient-derived pluripotent stem cell model. Neuromuscular Disorders   
Chesshyre M, Ridout D, Hashimoto Y, Ookubo Y, Torelli S, Maresh K, Ricotti V, Abbott L, Gupta VA, Main M, Ferrari G, Kowala A, Lin Y, Tedesco FS, Scoto M, Baranello G, Manzur A, Aoki Y and Muntoni F (2022). Investigating the role of dystrophin isoform deficiency in motor function in Duchenne muscular dystrophy. Wiley  Journal of Cachexia Sarcopenia and Muscle  vol. 13, (2) 1360-1372.  

2021

Marino S (2021). Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC‐derived neural stem cells in glioblastoma. Nature Research (Part of Springer Nature)  Nature Communications   
Paredes-Redondo A, Harley P, Maniati E, Ryan D, Louzada S, Meng J, Kowala A, Fu B, Yang F, Liu P, Marino S, Pourquié O, Muntoni F, Wang J, Lieberam I and Lin YY (2021). Optogenetic modeling of human neuromuscular circuits in Duchenne muscular dystrophy with CRISPR and pharmacological corrections. Science Advances  vol. 7, (37)  

2019

Kim J, Lana B, Torelli S, Ryan D, Catapano F, Ala P, Luft C, Stevens E, Konstantinidis E, Louzada S, Fu B, Paredes‐Redondo A, Chan AE, Yang F, Stemple DL, Liu P, Ketteler R, Selwood DL, Muntoni F and Lin Y (2019). A new patient‐derived iPSC model for dystroglycanopathies validates a compound that increases glycosylation of α‐dystroglycan. Springer Nature  Embo Reports  vol. 20, (11)  
Paredes‐Redondo A and Lin Y (2019). Human Induced Pluripotent Stem Cells: Challenges and Opportunities in Developing New Therapies for Muscular Dystrophies. Encyclopedia of Life Sciences  Wiley   

2016

Bevan N, Bevan L, Brown S, van Bokhoven H, Campbell KP, Cirak S, Cisneros B, Colognato H, Hohenester E, Lefeber D, Liljedahl M, Lu Q, Seta N, Shcherbata H, Straub V, Winder S and LIN Y (2016). 220th ENMC workshop: Dystroglycan and the dystroglycanopathies Naarden, The Netherlands, 27–29 May 2016. 
Praissman JL, Willer T, Sheikh MO, Toi A, Chitayat D, Lin Y-Y, Lee H, Stalnaker SH, Wang S, Prabhakar PK, Nelson SF, Stemple DL, Moore SA, Moremen KW, Campbell KP and Wells L (2016). The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition. Elife  vol. 5,  

2013

Carss KJ, Stevens E, Foley AR, Cirak S, Riemersma M, Torelli S, Hoischen A, Willer T, van Scherpenzeel M, Moore SA, Messina S, Bertini E, Bönnemann CG, Abdenur JE, Grosmann CM, Kesari A, Punetha J, Quinlivan R, Waddell LB, Young HK, Wraige E, Yau S, Brodd L, Feng L, Sewry C, MacArthur DG, North KN, Hoffman E, Stemple DL and Hurles ME (2013). Mutations in GDP-mannose pyrophosphorylase B cause congenital and limb-girdle muscular dystrophies associated with hypoglycosylation of α-dystroglycan. Am J Hum Genet  vol. 93, (1) 29-41.  
Carss KJ, Stevens E, Foley AR, Cirak S, Riemersma M, Torelli S, Hoischen A, Willer T, Van Scherpenzeel M, Moore SA, Messina S, Bertini E, Bönnemann CG, Abdenur JE, Grosmann CM, Kesari A, Punetha J, Quinlivan R, Waddell LB, Young HK, Wraige E, Yau S, Brodd L, Feng L, Sewry C, MacArthur DG, North KN, Hoffman E, Stemple DL and Hurles ME (2013). Mutations in GDP-mannose pyrophosphorylase B cause congenital and limb-girdle muscular dystrophies associated with hypoglycosylation of α-dystroglycan. American Journal of Human Genetics  vol. 93, (1) 29-41.  
Stevens E, Carss KJ, Cirak S, Foley R, Torelli S, Willer T, Tambunan DE, Yau S, Brodd L, Sewry CA, Feng L, Haliloglu G, Orhan D, Dobyns WB, Enns GM, Manning M, Krause A, Salih MA, Walsh CA, Hurles M, Campbell KP, Manzini MC, Stemple D, Lin Y-Y and Muntoni F (2013). Mutations in B3GALNT2 Cause Congenital Muscular Dystrophy and Hypoglycosylation of α-Dystroglycan. American Journal of Human Genetics  vol. 92, (3) 354-365.  
Buysse K, Riemersma M, Powell G, van Reeuwijk J, Chitayat D, Roscioli T, Kamsteeg E-J, van den Elzen C, van Beusekom E, Blaser S, Babul-Hirji R, Halliday W, Wright GJ, Stemple DL, Lin Y-Y, Lefeber DJ and van Bokhoven H (2013). Missense mutations in-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) cause WalkerWarburg syndrome. Human Molecular Genetics  vol. 22, (9) 1746-1754.  

2012

Lin Y-Y (2012). Muscle diseases in the zebrafish. Neuromuscul Disord  vol. 22, (8) 673-684.  
Roscioli T, Kamsteeg EJ, Buysse K, Maystadt I, Van Reeuwijk J, Van Den Elzen C, Van Beusekom E, Riemersma M, Pfundt R, Vissers LELM, Schraders M, Altunoglu U, Buckley MF, Brunner HG, Grisart B, Zhou H, Veltman JA, Gilissen C, Mancini GMS, Delrée P, Willemsen MA, Ramadža DP, Chitayat D, Bennett C, Sheridan E, Peeters EAJ, Tan-Sindhunata GMB, De Die-Smulders CE, Devriendt K and Kayserili H (2012). Mutations in ISPD cause Walker-Warburg syndrome and defective glycosylation of α-dystroglycan. Nature Genetics  vol. 44, (5) 581-585.  

2011

Lin Y-Y, White RJ, Torelli S, Cirak S, Muntoni F and Stemple DL (2011). Zebrafish Fukutin family proteins link the unfolded protein response with dystroglycanopathies. Hum Mol Genet  vol. 20, (9) 1763-1775.  

2009

Lin Y-Y and Gubb D (2009). Molecular dissection of Drosophila Prickle isoforms distinguishes their essential and overlapping roles in planar cell polarity. Dev Biol  vol. 325, (2) 386-399.  

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
solid heart iconUnravelling mechanisms of drug-induced myocarditis using immune-responsive human cardiovascular chip
Yung-Yao Lin and Julien Gautrot
£121,420 MRC Medical Research Council (01-10-2024 - 30-09-2028)


solid heart iconNatalia Moreno Sierra NC3R Early Career Engagement Award
Yung-Yao Lin
£10,000 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research (01-02-2024 - 15-06-2024)
solid heart icon3D bio-printing human pluripotent stem cell-derived skeletal muscle constructs for disease modelling
Yung-Yao Lin and John Connelly
£91,761 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research (01-11-2020 - 15-06-2024)
bullet iconMultimodal Comparative Study of Human iPSC-Derived and Primary Skeletal Muscle Progenitor Cells
Yung-Yao Lin and Charles Knowles
£1,125 King's College London (KCL) (01-07-2020 - 30-06-2021)