Endogenous C-type natriuretic peptide offsets the pathogenesis of steatohepatitis, hepatic fibrosis and portal hypertension
Perez-Ternero C, Li W, Aubdool AA, Goldin RD, Loy J, Devalia K, Alazawi W and Hobbs AJ
Pnas Nexus, Oxford University Press (Oup) 
30-12-2024

Zinc-mediated inhibition of soluble epoxide hydrolase promotes pulmonary hypertension
de Jesus DS, Buffonge S, Abis G, Buccafusca R, Baliga R, Warren HR, Hobbs A, Ruppert C, Weiss A, Schermuly RT, Eaton P and Charles R
Free Radical Biology and Medicine, Elsevier vol. 224 
01-11-2024

Cardiomyocyte-derived C-type natriuretic peptide diminishes myocardial ischaemic injury by promoting revascularisation and limiting fibrotic burden
Lowe VJ, Aubdool AA, Moyes AJ, Dignam JP, Perez-Ternero C, Baliga RS, Smart N and Hobbs AJ
Pharmacological Research, Elsevier vol. 209 
05-10-2024

C-type natriuretic peptide (CNP): The cardiovascular system and beyond
Dickinson YA, Moyes AJ and Hobbs AJ
Pharmacology & Therapeutics, Elsevier vol. 262 
21-08-2024

Targeting the natriuretic peptide system to treat preeclampsia
de Alwis N, Hannan NJ, Fato B, Beard S, Hobbs A, Lino TK, Binder N and Bubb K
Pregnancy Hypertension, Elsevier vol. 36 
01-08-2024

NKX2-5 regulates vessel remodelling in scleroderma-associated pulmonary arterial hypertension
Papaioannou I, Dritsoula A, Kang P, Baliga RS, Trinder SL, Cook E, Xu S, Hobbs A, Denton CP, Abraham DJ and Ponticos M
Jci Insight, American Society For Clinical Investigation vol. 9 (10) 
23-04-2024

Astrocytes produce nitric oxide via nitrite reduction in mitochondria to regulate cerebral blood flow during brain hypoxia
Christie IN, Theparambil SM, Braga A, Doronin M, Hosford PS, Brazhe A, Mascarenhas A, Nizari S, Hadjihambi A, Wells JA, Hobbs A, Semyanov A, Abramov AY, Angelova PR and Gourine AV
Cell Reports, Elsevier vol. 42 (12) 
30-11-2023

Abstract 15171: Endothelium-Derived C-Type Natriuretic Peptide Prevents the Development and Progression of Abdominal Aortic Aneurysm
Aubdool AA, Moyes AJ, Perez-Ternero C, Tsui JC, Lu HS, Daugherty A and Hobbs AJ
Circulation, Wolters Kluwer vol. 148 (Suppl_1), a15171-a15171.  
07-11-2023

The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA, Beuve A, Brouckaert P, Bryant C, Burnett JC, Farndale RW, Friebe A, Garthwaite J, Hobbs AJ, Jarvis GE, Koesling D, Kuhn M, MacEwan D, Monie TP, Potter LR, Russwurm M, Schmidt HHHW, Stasch J-P and Waldman SA
British Journal of Pharmacology, Wiley vol. 180 (S2), s241-s288.  
01-10-2023

PO3_08. C-type natriuretic peptide relaxes omental arteries in a new ex vivo model of preeclampsia
Fato BR, de Alwis N, Hobbs AJ, Kaitu'u-Lino TJ, Bubb KJ and Hannan NJ
Pregnancy Hypertension, Elsevier vol. 33 
01-09-2023

Novel enhancers of guanylyl cyclase‐A activity acting via allosteric modulation
Andresen H, Pérez‐Ternero C, Robinson J, Dickey DM, Hobbs AJ, Potter LR, Levy FO, Cataliotti A and Moltzau LR
British Journal of Pharmacology, Wiley vol. 180 (24), 3254-3270.  
29-08-2023

C-Type Natriuretic Peptide Signalling Attenuates the Development of Pulmonary Hypertension and Right Ventricular Remodelling
Dignam JP, Perez-Ternero C, Aubdool AA and Hobbs AJ
 
01-05-2023

Receptor guanylyl cyclase (RGC) family in GtoPdb v.2023.1
Beuve A, Brouckaert P, Burnett JC, Friebe A, Garthwaite J, Hobbs AJ, Koesling D, Kuhn M, Potter LR, Russwurm M, Schmidt HHHW, Stasch J-P and Waldman SA
Iuphar/Bps Guide to Pharmacology Cite, University of Edinburgh vol. 2023 (1) 
26-04-2023

C-type natriuretic peptide preserves central neurological function by maintaining blood-brain barrier integrity
Perez-Ternero C, Pallier PN, Tremoleda JL, Delogu A, Fernandes C, Michael-Titus AT and Hobbs AJ
Frontiers in Molecular Neuroscience, Frontiers vol. 15 
04-10-2022

The reaction of hydropersulfides (RSSH) with S-nitrosothiols (RS-NO) and the biological/physiological implications
Zarenkiewicz J, Perez-Ternero C, Kojasoy V, McGinity C, Khodade VS, Lin J, Tantillo DJ, Toscano JP, Hobbs AJ and Fukuto JM
Free Radical Biology and Medicine, Elsevier vol. 188, 459-467.  
06-07-2022

C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis.
Perez-Ternero C, Aubdool AA, Makwana R, Sanger GJ, Stimson RH, Chan LF, Moyes AJ and Hobbs AJ
Proc Natl Acad Sci U S A vol. 119 (13) 
29-03-2022

A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C
Smith RJ, Perez-Ternero C, Conole D, Martin C, Myers SH, Hobbs AJ and Selwood DL
Journal of Medicinal Chemistry, American Chemical Society (Acs) vol. 65 (7), 5495-5513.  
25-03-2022

Hydropersulfides (RSSH) and Nitric Oxide (NO) Signaling: Possible Effects on S-Nitrosothiols (RS-NO)
Fukuto JM, Perez-Ternero C, Zarenkiewicz J, Lin J, Hobbs AJ and Toscano JP
Antioxidants, Mdpi vol. 11 (1) 
16-01-2022

Innovative Anti-Inflammatory and Pro-resolving Strategies for Pulmonary Hypertension: High Blood Pressure Research Council of Australia Award 2019.
Scott TE, Qin CX, Drummond GR, Hobbs AJ and Kemp-Harper BK
Hypertension vol. 78 (5), 1168-1184.  
01-11-2021

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors
Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Beuve A, Brouckaert P, Bryant C, Burnett JC, Farndale RW, Friebe A, Garthwaite J, Hobbs AJ, Jarvis GE, Kuhn M, MacEwan D, Monie TP, Papapetropoulos A, Potter LR, Schmidt HHHW, Szabo C and Waldman SA
British Journal of Pharmacology vol. 178 (S1), S264-S312.  
01-10-2021

Receptor guanylyl cyclase (RGC) family in GtoPdb v.2021.3
Beuve A, Brouckaert P, Burnett JC, Friebe A, Garthwaite J, Hobbs AJ, Koesling D, Kuhn M, Potter LR, Russwurm M, Schmidt HHHW, Stasch J-P and Waldman SA
Iuphar/Bps Guide to Pharmacology Cite vol. 2021 (3) 
02-09-2021

Cyclic GMP modulating drugs in cardiovascular diseases: mechanism-based network pharmacology
Petraina A, Nogales C, Krahn T, Mucke H, Lüscher TF, Fischmeister R, Kass DA, Burnett JC, Hobbs AJ and Schmidt HHHW
Cardiovascular Research, Oxford University Press (Oup) vol. 118 (9), 2085-2102.  
16-07-2021

Multidrug resistance proteins preferentially regulate natriuretic peptide‐driven cGMP signalling in the heart and vasculature
Grange RMH, Preedy MEJ, Renukanthan A, Dignam JP, Lowe VJ, Moyes AJ, Pérez‐Ternero C, Aubdool AA, Baliga RS and Hobbs AJ
British Journal of Pharmacology, Wiley vol. 179 (11), 2443-2459.  
13-07-2021

Animal models of pulmonary hypertension: Getting to the heart of the problem
Dignam JP, Scott TE, Kemp‐Harper BK and Hobbs AJ
British Journal of Pharmacology, Wiley vol. 179 (5), 811-837.  
12-05-2021

A comparison of the chemical biology of hydropersulfides (RSSH) with other protective biological antioxidants and nucleophiles
Fukuto JM and Hobbs AJ
Nitric Oxide, Elsevier vol. 107, 46-57.  
28-11-2020

Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia
Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S, Hobbs AJ, Thiemermann C and Tinker A
Journal of Molecular Medicine, Springer Science and Business Media Llc 
06-07-2020

Receptor guanylyl cyclase (RGC) family (version 2020.3) in the IUPHAR/BPS Guide to Pharmacology Database
Beuve A, Brouckaert P, Burnett JC, Friebe A, Garthwaite J, Hobbs AJ, Koesling D, Kuhn M, Potter LR, Russwurm M, Schmidt HHHW, Stasch J-P and Waldman SA
Iuphar/Bps Guide to Pharmacology Cite vol. 2020 (3) 
19-06-2020

Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti-platelet therapy
Armstrong P, Ferreira PM, Chan M, Lundberg Slingsby M, Crescente M, Shih C, Kirkby N, Hobbs A and Warner T
Journal of Thrombosis and Haemostasis, Wiley 
04-05-2020

Repurposing an anti‐cancer agent for the treatment of hypertrophic heart disease
Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J, Bedi KC, Margulies KB, Sanz‐Moreno V, Hobbs A and Hodivala‐Dilke K
The Journal of Pathology, Wiley vol. 249 (4), 523-535.  
30-10-2019

Receptor guanylyl cyclase (RGC) family (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Beuve A, Brouckaert P, Burnett JC, Friebe A, Garthwaite J, Hobbs AJ, Koesling D, Kuhn M, Potter LR, Russwurm M, Schmidt HHHW, Stasch J-P and Waldman SA
Iuphar/Bps Guide to Pharmacology Cite vol. 2019 (4) 
16-09-2019

Nitric oxide biology & pathobiology (3rd edition) editors: Louis Ignarro & Bruce Freeman
Hobbs AJ
Nitric Oxide, Elsevier vol. 90 
01-09-2019

Multiplicity of Nitric Oxide and Natriuretic Peptide Signalling in Heart Failure.
Preedy MEJ, Baliga RS and Hobbs AJ
Journal of Cardiovascular Pharmacology, Lippincott, Williams & Wilkins 
24-07-2019

Correction to: Soluble Guanylate Cyclase Stimulators and Activators.
Sandner P, Zimmer DP, Milne GT, Follmann M, Hobbs A and Stasch J-P
Handbook of Experimental Pharmacology, Springer Verlag 
05-07-2019

C-Type Natriuretic Peptide: A Multifaceted Paracrine Regulator in the Heart and Vasculature
Moyes AJ and Hobbs AJ
International Journal of Molecular Sciences, Mdpi vol. 20 (9) 
08-05-2019

Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double‐blind, placebo‐controlled, proof‐of‐concept trial
Hobbs AJ, Moyes AJ, Baliga RS, Ghedia D, Ochiel R, Sylvestre Y, Doré CJ, Chowdhury K, Maclagan K, Quartly HL, Sofat R, Smit A, Schreiber BE, Coghlan GJ and MacAllister RJ
British Journal of Pharmacology, Wiley vol. 176 (9), 1251-1267.  
31-03-2019

C-type natriuretic peptide co-ordinates cardiac structure and function
Moyes AJ, Chu SM, Aubdool AA, Dukinfield MS, Margulies KB, Bedi KC, Hodivala-Dilke K, Baliga RS and Hobbs AJ
European Heart Journal, Oxford University Press (Oup) vol. 41 (9), 1006-1020.  
21-03-2019

Soluble Guanylate Cyclase Stimulators and Activators.
Sandner P, Zimmer DP, Milne GT, Follmann M, Hobbs A and Stasch J-P
Handb Exp Pharmacol 
29-01-2019

Endothelial C-Type Natriuretic Peptide is a Critical Regulator of Angiogenesis and Vascular Remodeling.
Bubb KJ, Aubdool AA, Moyes AJ, Lewis S, Drayton JP, Tang O, Mehta V, Zachary IC, Abraham DJ, Tsui J and Hobbs AJ
Circulation 
11-12-2018

Biophysical screening methods for extracellular domain peptide receptors, application to natriuretic peptide receptor C ligands
Conole D, Myers SH, Mota F, Hobbs AJ and Selwood DL
Chemical Biology & Drug Design, Wiley vol. 93 (6), 1011-1020.  
10-10-2018

Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure.
Baliga RS, Preedy MEJ, Dukinfield MS, Chu SM, Aubdool AA, Bubb KJ, Moyes AJ, Tones MA and Hobbs AJ
Proc Natl Acad Sci U S A 
16-07-2018

Inflammasomes: a novel therapeutic target in pulmonary hypertension?
Scott TE, Kemp‐Harper BK and Hobbs AJ
British Journal of Pharmacology, Wiley vol. 176 (12), 1880-1896.  
27-06-2018

Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology
Fukuto JM, Ignarro LJ, Nagy P, Wink DA, Kevil CG, Feelisch M, Cortese‐Krott MM, Bianco CL, Kumagai Y, Hobbs AJ, Lin J, Ida T and Akaike T
Febs Letters, Wiley vol. 592 (12), 2140-2152.  
24-05-2018

Angiotensin II Promotes KV7.4 Channels Degradation Through Reduced Interaction With HSP90 (Heat Shock Protein 90)
Barrese V, Stott JB, Figueiredo HB, Aubdool AA, Hobbs AJ, Jepps TA, McNeish AJ and Greenwood IA
Hypertension, Wolters Kluwer vol. 71 (6), 1091-1100.  
23-04-2018

Potent Anti‐Inflammatory and Pro‐Resolving Effects of Anabasum in a Human Model of Self‐Resolving Acute Inflammation
Motwani MP, Bennett F, Norris PC, Maini AA, George MJ, Newson J, Henderson A, Hobbs AJ, Tepper M, White B, Serhan CN, MacAllister R and Gilroy DW
Clinical Pharmacology & Therapeutics, Wiley vol. 104 (4), 675-686.  
30-01-2018

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview
Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA, Abbracchio MP, Aldrich R, Al-Hosaini K, Arumugam TV, Attali B, Bäck M, Barnes NM, Bathgate R, Beart PM, Becirovic E, Bettler B, Biel M and Birdsall NJ
British Journal of Pharmacology vol. 174, S1-S16.  
01-12-2017

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017.
Kapil V
Bmc Pharmacol Toxicol vol. 18 (Suppl 1), 64-64.  
10-10-2017

The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle
Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R, Mifsud B, Munroe PB, Xiao Q, Townsend-Nicholson A, Hobbs AJ, Ye S and Caulfield MJ
Human Molecular Genetics, Oxford University Press (Oup) vol. 27 (1), 199-210.  
10-10-2017

Functional pharmacological characterization of SER100 in cardiovascular health and disease
Villar IC, Bubb KJ, Moyes AJ, Steiness E, Gulbrandsen T, Levy FO and Hobbs AJ
Br J Pharmacol, Wiley 
25-09-2016

[OP.7C.08] BLOOD-PRESSURE ASSOCIATED VARIANTS IN NPR3 AFFECT HUMAN VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION AND CALCIUM RESPONSE TO ANGIOTENSIN II
Ren M, Ng F, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S and Caulfield MJ
 
01-09-2016

A Janus-Faced Role for Atrial Natriuretic Peptide in Myocardial Infarction?
Hobbs AJ
Circ Res vol. 119 (2), 181-183.  
08-07-2016

Guanylyl cyclase can't stand the HETE.
Hobbs AJ
Am J Physiol Heart Circ Physiol vol. 310 (11), H1608-H1610.  
01-06-2016

IkB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD
Chen J, Kieswich J, Chiazza F, Moyes A, Gobbetti T, Purvis G, Salvatori D, Patel N, Perretti M, Hobbs A, Collino M, Yaqoob M and THIEMERMANN C
Journal of The American Society of Nephrology, American Society of Nephrology 
06-05-2016

Raised arterial blood pressure in neurokinin-1 receptor-deficient mice ( NK1R −/− ): evidence for a neural rather than a vascular mechanism
Moyes AJ, Stanford SC, Hosford PS, Hobbs AJ and Ramage AG
Experimental Physiology vol. 101 (5), 588-598.  
09-04-2016

Clinical Relevance of Cyclic GMP Modulators: A Translational Success Story of Network Pharmacology
Oettrich JM, Dao VT, Frijhoff J, Kleikers PWM, Casas AI, Hobbs AJ and Schmidt HHHW
Clinical Pharmacology & Therapeutics vol. 99 (4), 360-362.  
13-02-2016

Abstract 19478: Endothelial and Cardiomyocyte -derived C-type Natriuretic Peptide Coordinate Heart Structure and Function
Moyes AJ, Chu SM, Baliga RS and Hobbs AJ
Circulation, Wolters Kluwer vol. 132 (suppl_3) 
10-11-2015

The nuances of NO synthase regulation in sepsis: Could targeting BH4 be the answer?
Sand CA and Hobbs AJ
Vascular Pharmacology, Elsevier vol. 77, 35-37.  
07-11-2015

Investigation of the role of multidrug resistance proteins (MRPs) in vascular homeostasis
Allen RMH, Renukanthan A, Bubb KJ, Villar IC, Moyes AJ, Baliga RS and Hobbs AJ
Bmc Pharmacology and Toxicology, Springer Nature vol. 16 (Suppl 1) 
02-09-2015

Pivotal vascular homeostatic role for endothelium-derived C-type natriuretic peptide (CNP)
Hobbs AJ
Bmc Pharmacology and Toxicology, Springer Nature vol. 16 (Suppl 1) 
02-09-2015

Abstract P048: Blood-Pressure Associated Variants in Natriuretic Peptide Receptor C Affect Human Vascular Smooth Muscle Cells Proliferation and Calcium Flux in Response to Angiotensin II
Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S and Caulfield M
Hypertension, Wolters Kluwer vol. 66 (suppl_1) 
01-09-2015

Bile duct‐ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences
O'Brien A, China L, Massey KA, Nicolaou A, Winstanley A, Newson J, Hobbs A, Audzevich T and Gilroy DW
Liver International, Wiley vol. 36 (6), 837-846.  
22-06-2015

Investigation of the Role of Multidrug Resistance Proteins (MRPs) in Vascular Homeostasis
Allen R, Renukanthan A, Bubb K, Villar I, Moyes A, Baliga R and Hobbs A
The Faseb Journal, Wiley vol. 29 (S1) 
01-04-2015

Extending the translational potential of targeting NO/cGMP‐regulated pathways in the CVS
Papapetropoulos A, Hobbs AJ and Topouzis S
British Journal of Pharmacology, Wiley vol. 172 (6), 1397-1414.  
12-01-2015

Blood-pressure associated variants in NPR3 affect human vascular smooth muscle cells proliferation and calcium response to angiotensin II
Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S and Caulfield M
 
01-01-2015

Modulation of cGMP Synthesis and Metabolism
Bubb KJ, Hobbs AJ and Klinger JR
In Diagnosis and Management of Pulmonary Hypertension, Springer Nature 355-375.  
01-01-2015

Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility.
Ono K, Akaike T, Sawa T, Kumagai Y, Wink DA, Tantillo DJ, Hobbs AJ, Nagy P, Xian M, Lin J and Fukuto JM
Free Radic Biol Med vol. 77, 82-94.  
01-12-2014

Endothelial C-type natriuretic peptide maintains vascular homeostasis.
Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ, Rebstock A-S, Worthington RJ, Simone MI, Mota F, Rivilla F, Vallejo S, Peiró C, Sánchez Ferrer CF, Djordjevic S, Caulfield MJ, MacAllister RJ, Selwood DL, Ahluwalia A and Hobbs AJ
J Clin Invest vol. 124 (9), 4039-4051.  
01-09-2014

Inhibition of phosphodiesterase 2 augments cGMP and cAMP signaling to ameliorate pulmonary hypertension.
Bubb KJ, Trinder SL, Baliga RS, Patel J, Clapp LH, MacAllister RJ and Hobbs AJ
Circulation vol. 130 (6), 496-507.  
05-08-2014

Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis.
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ and Hobbs AJ
Br J Pharmacol vol. 171 (14), 3463-3475.  
01-07-2014

Natriuretic peptide receptors and heart failure: to B or not to B blocked?
Hobbs AJ
Naunyn Schmiedebergs Arch Pharmacol vol. 387 (1), 1-4.  
01-01-2014

Light-triggered carbon monoxide delivery with Al-MCM-41-based nanoparticles bearing a designed manganese carbonyl complex
Gonzales MA, Han H, Moyes A, Radinos A, Hobbs AJ, Coombs N, Oliver SRJ and Mascharak PK
Journal of Materials Chemistry B vol. 2 (15), 2107-2113.  
01-01-2014

The Concise Guide to PHARMACOLOGY 2013/14: Overview
Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ, Abul-Hasn N, Anderson CM, Anderson CMH, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJM, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P and Calo G
British Journal of Pharmacology, Wiley vol. 170 (8), 1449-1458.  
01-12-2013

Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension.
Derrett-Smith EC, Dooley A, Gilbane AJ, Trinder SL, Khan K, Baliga R, Holmes AM, Hobbs AJ, Abraham D and Denton CP
Arthritis Rheum vol. 65 (11), 2928-2939.  
01-11-2013

Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential.
Ghosh SM, Kapil V, Fuentes-Calvo I, Bubb KJ, Pearl V, Milsom AB, Khambata R, Maleki-Toyserkani S, Yousuf M, Benjamin N, Webb AJ, Caulfield MJ, Hobbs AJ and Ahluwalia A
Hypertension vol. 61 (5), 1091-1102.  
01-05-2013

Vasoactive peptides and the pathogenesis of pulmonary hypertension: role and potential therapeutic application.
Baliga RS, Macallister RJ and Hobbs AJ
Handb Exp Pharmacol vol. 218, 477-511.  
01-01-2013

Letter by Ahluwalia and Hobbs Regarding Article, Nitrate-Nitrite-Nitric Oxide Pathway in Pulmonary Arterial Hypertension Therapeutics
Ahluwalia A and Hobbs AJ
Circulation vol. 127 (2), E275-E275.  
01-01-2013

C2238 Atrial Natriuretic Peptide Molecular Variant Is Associated With Endothelial Damage and Dysfunction Through Natriuretic Peptide Receptor C Signaling
Sciarretta S, Marchitti S, Bianchi F, Moyes A, Barbato E, Di Castro S, Stanzione R, Cotugno M, Castello L, Calvieri C, Eberini I, Sadoshima J, Hobbs AJ, Volpe M and Rubattu S
Circulation Research vol. 112 (10), 1355-+.  
01-01-2013

Vasoactive Peptides and the Pathogenesis of Pulmonary Hypertension: Role and Potential Therapeutic Application
Baliga RS, MacAllister RJ and Hobbs AJ
In Pharmacotherapy of Pulmonary Hypertension, Springer Nature 477-511.  
01-01-2013

Distinct endothelial pathways underlie sexual dimorphism in vascular auto-regulation.
Chan MV, Bubb KJ, Noyce A, Villar IC, Duchene J, Hobbs AJ, Scotland RS and Ahluwalia A
Br J Pharmacol vol. 167 (4), 805-817.  
01-10-2012

Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase.
Baliga RS, Milsom AB, Ghosh SM, Trinder SL, Macallister RJ, Ahluwalia A and Hobbs AJ
Circulation vol. 125 (23), 2922-2932.  
12-06-2012

Manganese Carbonyls Bearing Tripodal Polypyridine Ligands as Photoactive Carbon Monoxide-Releasing Molecules
Gonzalez MA, Yim MA, Cheng S, Moyes A, Hobbs AJ and Mascharak PK
Inorganic Chemistry vol. 51 (1), 601-608.  
01-01-2012

Accelerated Atherogenesis and Diminished Vascular Integrity in Mice Lacking Endothelial C-Type Natriuretic Peptide
Moyes AJ, Khambata RS, Ahluwalia A and Hobbs AJ
Circulation vol. 126 (21) 
01-01-2012

Natriuretic peptide receptor-3 underpins the disparate regulation of endothelial and vascular smooth muscle cell proliferation by C-type natriuretic peptide.
Khambata RS, Panayiotou CM and Hobbs AJ
Br J Pharmacol vol. 164 (2b), 584-597.  
01-09-2011

LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8.
Pourcet B, Feig JE, Vengrenyuk Y, Hobbs AJ, Kepka-Lenhart D, Garabedian MJ, Morris SM, Fisher EA and Pineda-Torra I
Circ Res vol. 109 (5), 492-501.  
19-08-2011

Enhancing natriuretic peptide bioactivity prevents bleomycin-induced pulmonary fibrosis
Baliga RS, Trinder SL, Scotton CJ, Chambers RC, MacAllister RJ and Hobbs AJ
Bmc Pharmacology, Springer Nature vol. 11 (Suppl 1) 
01-08-2011

Design and development of novel non-peptide agonists at NPR-C
Quinteiro FM, Gane P, Rebstock A-S, Worthington R, Simone M, Djordevic S, Hobbs A and Selwood D
Bmc Pharmacology, Springer Nature vol. 11 (Suppl 1) 
01-08-2011

Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin.
Villar IC, Scotland RS, Khambata RS, Chan M, Duchene J, Sampaio AL, Perretti M, Hobbs AJ and Ahluwalia A
Arterioscler Thromb Vasc Biol vol. 31 (5), 1075-1083.  
01-05-2011

New perspectives for the treatment of pulmonary hypertension.
Baliga RS, MacAllister RJ and Hobbs AJ
Br J Pharmacol vol. 163 (1), 125-140.  
01-05-2011

Designed Iron Carbonyls as Carbon Monoxide (CO) Releasing Molecules: Rapid CO Release and Delivery to Myoglobin in Aqueous Buffer, and Vasorelaxation of Mouse Aorta
Gonzalez MA, Fry NL, Burt R, Davda R, Hobbs A and Mascharak PK
Inorg Chem vol. 50 (7), 3127-3134.  
04-04-2011

Response to Inorganic Nitrate for Blood Pressure Lowering?
Kapil V, Benjamin N, Hobbs A and Ahluwalia A
Hypertension vol. 57 (2), E3-E3.  
01-02-2011

Perturbed VEGF signalling within the pulmonary vasculature of a TGF beta dependent mouse model of systemic sclerosis
Derrett-Smith EC, Dooley A, Baliga R, Hobbs A, MacAllister R, Abraham D and Denton CP
Clin Exp Rheumatol vol. 28 (5), S63-S63.  
01-09-2010

Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury
Madhani M, Hall AR, Cuello F, Charles RL, Burgoyne JR, Fuller W, Hobbs AJ, Shattock MJ and Eaton P
Am J Physiol-Heart C vol. 299 (3), H827-H836.  
01-09-2010

Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.
Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, Arghandawi S, Pearl V, Benjamin N, Loukogeorgakis S, Macallister R, Hobbs AJ, Webb AJ and Ahluwalia A
Hypertension vol. 56 (2), 274-281.  
01-08-2010

Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A.
Panayiotou CM, Baliga R, Stidwill R, Taylor V, Singer M and Hobbs AJ
Br J Pharmacol vol. 160 (8), 2045-2054.  
01-08-2010

Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischemia-reperfusion injury in mice
Milsom AB, Patel NSA, Mazzon E, Tripatara P, Storey A, Mota-Filipe H, Sepodes B, Webb AJ, Cuzzocrea S, Hobbs AJ, Thiemermann C and Ahluwalia A
Nitric Oxide-Biol Ch vol. 22 (2), 141-148.  
15-02-2010

C-type Natriuretic Peptide (CNP): Cardiovascular Roles and Potential as a Therapeutic Target
Lumsden NG, Khambata RS and Hobbs AJ
Curr Pharm Design vol. 16 (37), 4080-4088.  
01-01-2010

The anti-atherogenic potential of C-type natriuretic peptide: Disparate regulation of endothelial and vascular smooth muscle cell proliferation via natriuretic peptide receptor-C
Khambata RS, Panayiotou CM, Xiao F and Hobbs AJ
Faseb Journal vol. 24 
01-01-2010

Chapter 9 Soluble Guanylate Cyclase Allosteric Activation and Redox Regulation
Hobbs AJ and Stasch J-P
In Nitric Oxide, Elsevier 301-326.  
01-01-2010

Soluble Guanylate Cyclase. Allosteric Activation and Redox Regulation.
Hobbs AJ and Stasch JP
In Nitric Oxide 301-326.  
01-01-2010

C-type natriuretic peptide (CNP): cardiovascular roles and potential as a therapeutic target.
Lumsden NG, Khambata RS and Hobbs AJ
Curr Pharm Des vol. 16 (37), 4080-4088.  
01-01-2010

Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis.
Duchene J, Cayla C, Vessillier S, Scotland R, Yamashiro K, Lecomte F, Syed I, Vo P, Marrelli A, Pitzalis C, Cipollone F, Schanstra J, Bascands J-L, Hobbs AJ, Perretti M and Ahluwalia A
Arterioscler Thromb Vasc Biol vol. 29 (11), 1757-1763.  
01-11-2009

The Effects of Nitroxyl (HNO) on Soluble Guanylate Cyclase Activity INTERACTIONS AT FERROUS HEME AND CYSTEINE THIOLS
Miller TW, Cherney MM, Lee AJ, Francoleon NE, Farmer PJ, King SB, Hobbs AJ, Miranda KM, Burstyn JN and Fukuto JM
J Biol Chem vol. 284 (33), 21788-21796.  
14-08-2009

Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans
Morris T, Stables M, Hobbs A, de Souza P, Colville-Nash P, Warner T, Newson J, Bellingan G and Gilroy DW
J Immunol vol. 183 (3), 2089-2096.  
01-08-2009

BLOOD PRESSURE LOWERING EFFECTS OF ORAL INORGANIC NITRATE VIA BIOCONVERSION TO NITRITE
Kapil V, Rehman F, Arghandawi S, Milsom A, Benjamin N, Hobbs A, MacAllister R, Webb A and Ahluwalia A
Basic Clin Pharmacol vol. 105, 31-31.  
01-08-2009

Manipulating the natriuretic peptide system for the treatment of pulmonary hypertension
Baliga RS, Trinder S, Scotton CJ, Chambers RC, MacAllister RJ and Hobbs AJ
Bmc Pharmacology, Springer Nature vol. 9 (Suppl 1) 
01-08-2009

ORAL INORGANIC NITRATE PROTECTS AGAINST ENDOTHELIAL ISCHAEMIA-REPERFUSION INJURY IN HUMANS
Okorie M, Akram F, Loukogeorgakis S, Webb A, Deanfield J, Benjamin N, Hobbs A, MacAllister R and Ahluwalia A
Basic Clin Pharmacol vol. 105, 26-26.  
01-08-2009

Response to Letter Regarding Article, Circulating Endothelial Progenitor Cells in Patients With Eisenmenger Syndrome and Idiopathic Pulmonary Arterial Hypertension
Diller GP, Bedard E, Wort SJ, Gatzoulis MA, van Eijl S, Ali O, Wilkins MR, Wharton J, Okonko DO, Howard LS, Thum T, Bauersachs J, Gibbs JSR and Hobbs AJ
Circulation vol. 119 (9), E231-E231.  
10-03-2009

Involvement of Fibroblast growth factor 10 (Fgf10) in the anterior-posterior patterning and specification of muscle and tendon progenitors in the developing mouse limbs
Hajihosseini MK, Ramasamy S, De Langhe S, Lana-Elola E, Rice D, Rio LQ, Kelly R, Sharpe J and Bellusci S
Faseb Journal vol. 23 
01-01-2009

Design and development of novel non-peptide agonists at natriuretic peptide receptor-C
Hobbs AJ, Gane P, Lumsden N, Nobles M, Rebstock A-S, Simone M, Villar I, Worthington R, Xiao F, Ahluwalia A and Selwood D
Faseb Journal vol. 23 
01-01-2009

NO-Independent, Haem-Dependent Soluble Guanylate Cyclase Stimulators
Stasch J-P and Hobbs AJ
In Cgmp: Generators, Effectors and Therapeutic Implications, Springer Nature 277-308.  
01-01-2009

Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase.
Webb AJ, Milsom AB, Rathod KS, Chu WL, Qureshi S, Lovell MJ, Lecomte FMJ, Perrett D, Raimondo C, Khoshbin E, Ahmed Z, Uppal R, Benjamin N, Hobbs AJ and Ahluwalia A
Circ Res vol. 103 (9), 957-964.  
24-10-2008

Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension.
Baliga RS, Zhao L, Madhani M, Lopez-Torondel B, Visintin C, Selwood D, Wilkins MR, MacAllister RJ and Hobbs AJ
Am J Respir Crit Care Med vol. 178 (8), 861-869.  
15-10-2008

Characterization of the human alpha(1)beta(1) soluble guanylyl cyclase promoter - Key role for NF-kappa B(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor
Marro ML, Peiro C, Panayiotou CM, Baliga RS, Meurer S, Schmidt HHHW and Hobbs AJ
J Biol Chem vol. 283 (29), 20027-20036.  
18-07-2008

Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension
Diller GP, van Eijl S, Okonko DO, Howard LS, Ali O, Thum T, Wort SJ, Bedard E, Gibbs JSR, Bauersachs J, Hobbs AJ, Wilkins MR, Gatzoulis MA and Wharton J
Circulation vol. 117 (23), 3020-3030.  
10-06-2008

Sex differences in vascular function: implication of endothelium-derived hyperpolarizing factor
Villar IC, Hobbs AJ and Ahluwalia A
J Endocrinol vol. 197 (3), 447-462.  
01-06-2008

Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFN gamma-dependent iNOS expression in the vasculature of healthy mice
Morton J, Coles B, Wright K, Gallimore A, Morrow JD, Terry ES, Anning PB, Morgan BP, Dioszeghy V, Kuhn H, Chaitidis P, Hobbs AJ, Jones SA and O'Donnell VB
Blood vol. 111 (10), 5187-5194.  
15-05-2008

Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite
Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, MacAllister R, Hobbs AJ and Ahluwalia A
Hypertension vol. 51 (3), 784-790.  
01-03-2008

Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A
Panayiotou CM, Stidwill R, Taylor V, Singer M and Hobbs AJ
Faseb Journal vol. 22 
01-01-2008

Acute blood pressure lowering and vasoprotective effects of dietary nitrate
Webb A, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin B, Macallister R, Hobbs A and Abluwalia A
Faseb Journal vol. 22 
01-01-2008

NPR-A gene deletion reverses vascular dysfunction associated with sepsis
Panayiotou CM and Hobbs AJ
Bmc Pharmacology, Springer Nature vol. 7 (Suppl 1) 
01-07-2007

Exploiting the natriuretic peptide system for the treatment of pulmonary hypertension
Hobbs AJ
Bmc Pharmacology, Springer Nature vol. 7 (Suppl 1) 
01-07-2007

Selective modulation of ANP-dependent dilatation in the pulmonary vasculature by PDE 5 inhibitors: a novel combination therapy for pulmonary hypertension?
Baliga RS, Zhao L, Wilkins MR, MacAllister RJ and Hobbs AJ
Bmc Pharmacology, Springer Nature vol. 7 (Suppl 1) 
01-07-2007

Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor
Villar IC, Panayiotou CM, Sheraz A, Madhani M, Scotland RS, Nobles M, Kemp-Harper B, Ahluwalia A and Hobbs AJ
Cardiovasc Res vol. 74 (3), 515-525.  
01-06-2007

The pharmacology of nitroxyl (HNO) and its therapeutic potential: Not just the janus face of NO
Paolocci N, Jackson MI, Lopez BE, Miranda K, Tocchetti CG, Wink DA, Hobbs AJ and Fukuto JM
Pharmacology & Therapeutics vol. 113 (2), 442-458.  
01-01-2007

Biological activity of designed photolabile metal nitrosyls: light-dependent activation of soluble guanylate cyclase and vasorelaxant properties in rat aorta.
Madhani M, Patra AK, Miller TW, Eroy-Reveles AA, Hobbs AJ, Fukuto JM and Mascharak PK
J Med Chem vol. 49 (25), 7325-7330.  
14-12-2006

Reciprocal regulation of human soluble and particulate guanylate cyclases in vivo.
Madhani M, Okorie M, Hobbs AJ and MacAllister RJ
Br J Pharmacol vol. 149 (6), 797-801.  
01-11-2006

Distinct pathways regulate endothelium derived hyperpolarising factor-mediated responses in rat mesenteric arteries
Villar IC, Ahluwalia A and Hobbs AJ
Acta Pharmacol Sin vol. 27 (9), 1276-1276.  
01-09-2006

Novel aspects of endothelium-dependent regulation of vascular tone
Villar IC, Francis S, Webb A, Hobbs AJ and Ahluwalia A
Kidney Int vol. 70 (5), 840-853.  
01-09-2006

Vascular inflammation modulates alpha 1 and beta 1 soluble guanylate cyclase promoter activity in human aortic smooth muscle cells (HASMCs)
Marro M, Panayiotou C and Hobbs A
Acta Pharmacol Sin vol. 27, 172-172.  
01-07-2006

C-Type natriuretic peptide mediates ERK1/2 phosphorylation via Gi-coupled natriuretic peptide receptor-C in rat aortic smooth muscle cells
Panayiotou CM and Hobbs AJ
Acta Pharmacol Sin vol. 27, 170-170.  
01-07-2006

C-type natriuretic peptide inhibits leukocyte recruitment and platelet-leukocyte interactions via suppression of P-selectin expression
Scotland RS, Cohen M, Foster P, Lovell M, Mathur A, Ahluwalia A and Hobbs AJ
P Natl Acad Sci Usa vol. 102 (40), 14452-14457.  
04-10-2005

Characterisation of human a1 and b1 soluble guanylate cyclase promoter activity in human aortic smooth muscle cells
Marro ML and Hobbs AJ
Bmc Pharmacology, Springer Nature vol. 5 (Suppl 1) 
01-06-2005

Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo.
Connelly L, Madhani M and Hobbs AJ
J Biol Chem vol. 280 (11), 10040-10046.  
18-03-2005

Endothelium-derived C-type natriuretic peptide: more than just a hyperpolarizing factor
Ahluwalia A and Hobbs AJ
Trends Pharmacol Sci vol. 26 (3), 162-167.  
01-03-2005

Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice - Key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo
Scotland RS, Madhani M, Chauhan S, Moncada S, Andresen J, Nilsson H, Hobbs AJ and Ahluwalia A
Circulation vol. 111 (6), 796-803.  
15-02-2005

C-type natniuretic peptide in vascular physiology and disease
Scotland RS, Ahluwalia A and Hobbs AJ
Pharmacol Therapeut vol. 105 (2), 85-93.  
01-02-2005

C-type natriuretic peptide: new candidate for endothelium-derived hyperpolarising factor.
Chauhan SD, Hobbs AJ and Ahluwalia A
Int J Biochem Cell Biol vol. 36 (10), 1878-1881.  
01-10-2004

Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury - Novel cardioprotective role for endothelium-derived C-type natriuretic peptide
Hobbs A, Foster P, Prescott C, Scotland R and Ahluwalia A
Circulation vol. 110 (10), 1231-1235.  
01-09-2004

Vascular actions of natriuretic peptides. Cyclic GMP-dependent and -independent mechanisms.
Ahluwalia A, MacAllister RJ and Hobbs AJ
Basic Res Cardiol vol. 99 (2), 83-89.  
01-03-2004

Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment
Ahluwalia A, Foster P, Scotland RS, McLean PG, Mathur A, Perretti M, Moncada S and Hobbs AJ
P Natl Acad Sci Usa vol. 101 (5), 1386-1391.  
03-02-2004

Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide.
AHLUWALIA A, Hobbs A, Prescott C, Scotland R and Foster P
Circulation vol. 110 (10), 1231-1235.  
01-01-2004

Antiplatelet properties of a novel, non-NO-based soluble guanylate cyclase activator, BAY 41-2272.
Hobbs AJ and Moncada S
Vascul Pharmacol vol. 40 (3), 149-154.  
01-10-2003

Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling.
Madhani M, Scotland RS, MacAllister RJ and Hobbs AJ
Br J Pharmacol vol. 139 (7), 1289-1296.  
01-08-2003

Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression.
Connelly L, Jacobs AT, Palacios-Callender M, Moncada S and Hobbs AJ
J Biol Chem vol. 278 (29), 26480-26487.  
18-07-2003

Interactions between soluble guanylate cyclase and natriuretic peptide receptor-linked particulate guanylate cyclases in the mammalian vasculature
Madhani M, MacAllister R and Hobbs A
Bmc News and Views, Springer Nature vol. 3 (S2) 
03-07-2003

Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor
Chauhan SD, Nilsson H, Ahluwalia A and Hobbs AJ
P Natl Acad Sci Usa vol. 100 (3), 1426-1431.  
04-02-2003

BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro.
Kalsi JS, Rees RW, Hobbs AJ, Royle M, Kell PD, Ralph DJ, Moncada S and Cellek S
J Urol vol. 169 (2), 761-766.  
01-02-2003

BAY41-2272, a Novel Nitric Oxide Independent Soluble Guanylate Cyclase Activator, Relaxes Human and Rabbit Corpus Cavernosum In Vitro
KALSI JS, REES RW, HOBBS AJ, ROYLE M, KELL PD, RALPH DJ, MONCADA S and CELLEK S
Journal of Urology, Wolters Kluwer vol. 169 (2), 761-766.  
01-02-2003

Protection against liposaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice.
AHLUWALIA A, Hobbs AJ, Seggara G, Chauhan SD, Vo PA and MacAllister RJ
Faseb J vol. 17 (6), 773-775.  
01-01-2003

Haemoglobin: NO transporter, NO inactivator or NOne of the above?
Hobbs AJ, Gladwin MT, Patel RP, Williams DLH and Butler AR
Trends Pharmacol Sci vol. 23 (9), 406-411.  
01-09-2002

Haernoglobin: NO transporter, NO inactivator or NOne of the above?
Hobbs AJ, Gladwin MT, Patel RP, Williams DLH and Butler AR
Trends Pharmacol Sci vol. 23 (9), 406-411.  
01-09-2002

Soluble guanylate cyclase: an old therapeutic target re-visited.
Hobbs AJ
Br J Pharmacol vol. 136 (5), 637-640.  
01-07-2002

Mechanisms underlying the vasorelaxant activity of C-type natriuretic peptide (CNP) in rat mesenteric resistance arteries
Chauhan SD, MacAllister RJ, Hobbs AJ and Ahluwalia A
Faseb J vol. 16 (4), A572-A572.  
20-03-2002

Biphasic regulation of NF-kappa B activity underlies the pro- and anti-inflammatory actions of nitric oxide.
Connelly L, Palacios-Callender M, Ameixa C, Moncada S and Hobbs AJ
J Immunol vol. 166 (6), 3873-3881.  
15-03-2001

Reciprocal regulation of cGMP-mediated vasorelaxation by soluble and particulate guanylate cyclases.
Hussain MB, MacAllister RJ and Hobbs AJ
Am J Physiol Heart Circ Physiol vol. 280 (3), H1151-H1159.  
01-03-2001

Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase
Selwood DL, Brummell DG, Budworth J, Burtin GE, Campbell RO, Chana SS, Charles IG, Fernandez PA, Glen RC, Goggin MC, Hobbs AJ, Kling MR, Liu Q, Madge DJ, Meillerais S, Powell KL, Reynolds K, Spacey GD, Stables JN, Tatlock MA, Wheeler KA, Wishart G and Woo CK
J Med Chem vol. 44 (1), 78-93.  
04-01-2001

Soluble guanylate cyclase
Hobbs AJ
Expert Opinion On Therapeutic Targets, Taylor & Francis vol. 4 (6), 735-749.  
01-12-2000

Synthesis and biological evaluation of enantiopure thionitrites: the solid-phase synthesis and nitrosation of D-glutathione as a molecular probe.
Cavero M, Hobbs A, Madge D, Motherwell WB, Selwood D and Potier P
Bioorg Med Chem Lett vol. 10 (7), 641-644.  
03-04-2000

Regulation of cGMP-mediated vasorelaxation in mouse thoracic aorta: Interactions of the soluble and particulate guanylate cyclases
Hussain MB, MacAllister RJ and Hobbs AJ
Brit J Pharmacol vol. 129 
01-01-2000

Gastrointestinal motility during pregnancy: role of nitrergic component of NANC nerves
Shah S, Hobbs A, Singh R, Cuevas J, Ignarro LJ and Chaudhuri G
American Journal of Physiology-Regulatory Integrative and Comparative Physiology vol. 279 (4), R1478-R1485.  
01-01-2000

Autoregulation of nitric oxide-soluble guanylate cyclase-cyclic GMP signalling in mouse thoracic aorta.
Hussain MB, Hobbs AJ and MacAllister RJ
Br J Pharmacol vol. 128 (5), 1082-1088.  
01-11-1999

Biochemical characterization of S-nitrosohemoglobin. Mechanisms underlying synthesis, no release, and biological activity.
Wolzt M, MacAllister RJ, Davis D, Feelisch M, Moncada S, Vallance P and Hobbs AJ
J Biol Chem vol. 274 (41), 28983-28990.  
08-10-1999

Chemistry and Molecular Biology of Nitric Oxide Synthesis
Hobbs AJ and Ignarro LJ
In The Haemodynamic Effects of Nitric Oxide, World Scientific Publishing 52-81.  
01-08-1999

Enhanced sensitivity of the soluble guanylate cyclase/cyclic GMP system in the eNOS knockout mouse
Hussain MB, Hobbs AJ and MacAllister RJ
Brit J Pharmacol vol. 126, U41-U41.  
01-03-1999

Inhibition of nitric oxide synthase as a potential therapeutic target.
Hobbs AJ, Higgs A and Moncada S
Annu Rev Pharmacol Toxicol vol. 39, 191-220.  
01-01-1999

Inducible nitric oxide synthase and inflammation
Hobbs AJ and Moncada S
In Inducible Enzymes in The Inflammatory Response, Springer Nature 31-54.  
01-01-1999

Soluble guanylate cyclase: the forgotten sibling.
Hobbs AJ
Trends Pharmacol Sci vol. 18 (12), 484-491.  
01-12-1997

Soluble guanylate cyclase: the forgotten sibling
Hobbs AJ
Trends in Pharmacological Sciences, Elsevier vol. 18 (4), 484-491.  
01-07-1997

Nitric oxide regulates endothelium-dependent vasodilator responses in rabbit hindquarters vascular bed in vivo.
Cohen GA, Hobbs AJ, Fitch RM, Zinner MJ, Chaudhuri G and Ignarro LJ
Am J Physiol vol. 271 (1 Pt 2), H133-H139.  
01-07-1996

Nitric oxide cyclic GMP signal transduction system
Hobbs AJ and Ignarro LJ
Nitric Oxide, Pt B vol. 269, 134-148.  
01-01-1996

ENHANCED ACTIONS OF NITRIC-OXIDE IN MODULATING GASTROINTESTINAL SMOOTH-MUSCLE FUNCTION DURING PREGNANCY
SHAH SN, CUEVAS JM, HOBBS AJ, WHANG E, IGNARRO LJ, ASHLEY SW and CHAUDHURI G
Gastroenterology vol. 108 (4), A1246-A1246.  
01-04-1995

Negative modulation of nitric oxide synthase by nitric oxide and nitroso compounds.
Griscavage JM, Hobbs AJ and Ignarro LJ
Adv Pharmacol vol. 34, 215-234.  
01-01-1995

CHANGES IN GASTROINTESTINAL SMOOTH-MUSCLE REACTIVITY DURING PREGNANCY MAY BE INDUCED BY NITRIC-OXIDE
SHAH SN, CUEVAS JM, HOBBS AJ, WHANG E, ASHLEY SW, IGNARRO LJ and CHAUDHURI G
Gastroenterology vol. 108 (4), A688-A688.  
01-01-1995

DIFFERENTIAL INHIBITORY EFFECT OF L-NAME ON ENDOTHELIUM-DEPENDENT RELAXATION IN-VITRO AND IN-VIVO
HOBBS AJ, COHEN GA, FITCH RM, YIN TL, CHAUDHURI G and IGNARRO LJ
Faseb Journal vol. 9 (3), A328-A328.  
01-01-1995

THE ROLE OF NITRIC-OXIDE IN MODULATING GASTROINTESTINAL SMOOTH-MUSCLE REACTIVITY DURING PREGNANCY
SHAH SN, CUEVAS JM, HOBBS AJ, WHANG E, ASHLEY SW, IGNARRO LJ and CHAUDHURI G
Faseb Journal vol. 9 (3), A86-A86.  
01-01-1995

STIMULATED RELEASE OF NITRIC-OXIDE (NO) IS LINKED TO ALPHA-ADRENOCEPTOR ACTIVATION IN-VIVO
COHEN GA, HOBBS AJ, FITCH RM, ASHLEY SW, CRYER MH, CHAUDHURI G and IGNARRO LJ
Faseb Journal vol. 9 (3), A328-A328.  
01-01-1995

FORMATION OF FREE NITRIC-OXIDE FROM L-ARGININE BY NITRIC-OXIDE SYNTHASE - DIRECT ENHANCEMENT OF GENERATION BY SUPEROXIDE-DISMUTASE
HOBBS AJ, FUKUTO JM and IGNARRO LJ
Proceedings of The National Academy of Sciences of The United States of America vol. 91 (23), 10992-10996.  
01-01-1994

FORMATION OF FREE NITRIC-OXIDE FROM L-ARGININE BY NITRIC-OXIDE SYNTHASE AND ENHANCEMENT OF GENERATION BY SUPEROXIDE-DISMUTASE
HOBBS AJ, GRISCAVAGE JM, ROGERS NE, BYRNS RE, FUKUTO JM and IGNARRO LJ
Faseb Journal vol. 8 (4), A360-A360.  
01-01-1994

Conversion of nitroxyl (HNO) to nitric oxide (NO) in biological systems: the role of physiological oxidants and relevance to the biological activity of HNO.
Fukuto JM, Hobbs AJ and Ignarro LJ
Biochem Biophys Res Commun vol. 196 (2), 707-713.  
29-10-1993

The influence of L-NG-nitro-arginine on sympathetic nerve induced contraction and noradrenaline release in the rat isolated anococcygeus muscle.
Brave SR, Bhat S, Hobbs AJ, Tucker JF and Gibson A
J Auton Pharmacol vol. 13 (3), 219-225.  
01-06-1993

An investigation of some S-nitrosothiols, and of hydroxy-arginine, on the mouse anococcygeus.
Gibson A, Babbedge R, Brave SR, Hart SL, Hobbs AJ, Tucker JF, Wallace P and Moore PK
Br J Pharmacol vol. 107 (3), 715-721.  
01-11-1992

Differentiation by hydroquinone of relaxations induced by exogenous and endogenous nitrates in non-vascular smooth muscle: role of superoxide anions.
Hobbs AJ, Tucker JF and Gibson A
Br J Pharmacol vol. 104 (3), 645-650.  
01-11-1991

The influence of L-NG-nitro-arginine on field stimulation induced contractions and acetylcholine release in guinea pig isolated tracheal smooth muscle.
Brave SR, Hobbs AJ, Gibson A and Tucker JF
Biochem Biophys Res Commun vol. 179 (2), 1017-1022.  
16-09-1991

Cyclic nucleotide content of the rat anococcygeus during relaxations induced by drugs or by non-adrenergic, non-cholinergic field stimulation.
Mirzazadeh S, Hobbs AJ, Tucker JF and Gibson A
J Pharm Pharmacol vol. 43 (4), 247-251.  
01-04-1991

L-NG-nitro-arginine and its methyl ester are potent inhibitors of non-adrenergic, non-cholinergic transmission in the rat anococcygeus.
Hobbs AJ and Gibson A
Br J Pharmacol vol. 100 (4), 749-752.  
01-08-1990

L-NG-nitro arginine inhibits non-adrenergic, non-cholinergic relaxations of guinea-pig isolated tracheal smooth muscle.
Tucker JF, Brave SR, Charalambous L, Hobbs AJ and Gibson A
Br J Pharmacol vol. 100 (4), 663-664.  
01-08-1990

L-NG-nitroarginine is a potent inhibitor of non-adrenergic, non-cholinergic relaxations in the rat anococcygeus muscle
Gibson A, Hobbs AJ and Mirzazadeh S
European Journal of Pharmacology, Elsevier vol. 183 (5) 
01-07-1990

L-NG-monomethyl arginine and L-NG-nitro arginine inhibit non-adrenergic, non-cholinergic relaxation of the mouse anococcygeus muscle.
Gibson A, Mirzazadeh S, Hobbs AJ and Moore PK
Br J Pharmacol vol. 99 (3), 602-606.  
01-03-1990