Prof Adrian Hobbs

Adrian Hobbs

Professor of Cardiovascular Pharmacology

The William Harvey Research Institute
Queen Mary University of London
+44 (0)20 7882 5778
www.qmul.ac.uk/whri/people/academic-staff/items/hobbsadrian.html

Research

Cardiovascular Models

Interests

Interest in 'lung-on-a-chip' and 'heart-on-a-chip' models; endothelial barrier function
Expertise in in vitro studies in human cells from healthy volunteers and patients

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2025

The Nitric Oxide Society and the Nitric Oxide Journal: Returning to our foundation to shape the future of redox biology
Cortese-Krott MM, Berra L, Bryan NS, Carlström M, Glynn S, Hobbs A, Miranda KM, Motohashi H et al.
Nitric Oxide, Elsevier Bv vol. 158, 25-26.  
01-10-2025
Endothelium-derived C-type natriuretic peptide offsets the pathogenesis of pulmonary hypertension
Dignam JP, Aubdool AA, Lowe VR, Perez-Ternero C, Moyes AJ, Nahal RS, Patel JA, Clapp LH et al.
Pharmacological Research, Elsevier Bv vol. 219, 107870-107870.  
01-09-2025
New directions for Nitric Oxide – Focused, rapid, and forward-looking
Cortese-Krott MM, Berra L, Hobbs A, Miranda KM, Motohashi H, Tejero J
Nitric Oxide, Elsevier Bv vol. 157, 66-67.  
01-08-2025
Endothelium- and Fibroblast-Derived C-Type Natriuretic Peptide Prevents the Development and Progression of Aortic Aneurysm
Aubdool AA, Moyes AJ, Perez-Ternero C, Baliga RS, Sanghera JS, Syed MT, Jaigirdar K, Panesar AK et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health) vol. 45 (7), 1044-1063.  
01-07-2025
Zinc-mediated Inhibition of Soluble Epoxide Hydrolase Promotes Pulmonary Hypertension
Simoes de Jesus D, Buffonge S, Abis G, Buccafusca R, Baliga R, Warren HR, Hobbs A, Ruppert C et al.
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society 
12-06-2025

2024

Endogenous C-type natriuretic peptide offsets the pathogenesis of steatohepatitis, hepatic fibrosis and portal hypertension
Perez Ternero C, Li W, Aubdool AA, Goldin RD, Loy J, Devalia K, Alazawi W, Hobbs AJ
Pnas Nexus, Oxford University Press (Oup), pgae579-pgae579.  
30-12-2024
Cardiomyocyte-derived C-type natriuretic peptide diminishes myocardial ischaemic injury by promoting revascularisation and limiting fibrotic burden
Lowe VJ, Aubdool AA, Moyes AJ, Dignam JP, Perez-Ternero C, Baliga RS, Smart N, Hobbs AJ
Pharmacological Research, Elsevier Bv vol. 209, 107447-107447.  
01-11-2024
Zinc-mediated inhibition of soluble epoxide hydrolase promotes pulmonary hypertension
Simoes de Jesus D, Buffonge S, Abis G, Buccafusca R, Baliga R, Warren HR, Hobbs A, Ruppert C et al.
Free Radical Biology and Medicine, Elsevier Bv vol. 224, S58-S58.  
01-11-2024
C-type natriuretic peptide (CNP): The cardiovascular system and beyond
Dickinson YA, Moyes AJ, Hobbs AJ
Pharmacology &Amp; Therapeutics, Elsevier Bv vol. 262, 108708-108708.  
01-10-2024
Activation of the C-Type Natriuretic Peptide Pathway Offers a Novel Therapeutic Target for Gestational Hypertension
Barsha G, Hong Q, Nelson J, Walton S, Hetherington K, Thomas J, Nicholls S, Hobbs A et al.
 
01-08-2024
Targeting the natriuretic peptide system to treat preeclampsia
de Alwis N, Hannan NJ, Fato B, Beard S, Hobbs A, Lino TK, Binder N, Bubb K
Pregnancy Hypertension, Elsevier Bv vol. 36, 55-55.  
01-08-2024
NKX2-5 regulates vessel remodeling in scleroderma-associated pulmonary arterial hypertension
Papaioannou I, Dritsoula A, Kang P, Baliga RS, Trinder SL, Cook E, Shiwen X, Hobbs AJ et al.
Jci Insight, American Society For Clinical Investigation vol. 9 (10) 
23-04-2024

2023

Astrocytes produce nitric oxide via nitrite reduction in mitochondria to regulate cerebral blood flow during brain hypoxia
Christie IN, Theparambil SM, Braga A, Doronin M, Hosford PS, Brazhe A, Mascarenhas A, Nizari S et al.
Cell Reports, Elsevier Bv vol. 42 (12), 113514-113514.  
01-12-2023
Abstract 15171: Endothelium-Derived C-Type Natriuretic Peptide Prevents the Development and Progression of Abdominal Aortic Aneurysm
Aubdool AA, Moyes AJ, Perez-Ternero C, Tsui JC, Lu HS, Daugherty A, Hobbs AJ
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 148 (Suppl_1) 
07-11-2023
The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E et al.
British Journal of Pharmacology, Wiley vol. 180 (S2) 
01-10-2023
PO3_08. C-type natriuretic peptide relaxes omental arteries in a new ex vivo model of preeclampsia
Fato BR, de Alwis N, Hobbs AJ, Kaitu'u-Lino TJ, Bubb KJ, Hannan NJ
Pregnancy Hypertension, Elsevier Bv vol. 33, e23-e23.  
01-09-2023
Novel enhancers of guanylyl cyclase‐A activity acting via allosteric modulation
Andresen H, Pérez‐Ternero C, Robinson J, Dickey DM, Hobbs AJ, Potter LR, Levy FO, Cataliotti A et al.
British Journal of Pharmacology, Wiley vol. 180 (24), 3254-3270.  
29-08-2023
C-Type Natriuretic Peptide Signalling Attenuates the Development of Pulmonary Hypertension and Right Ventricular Remodelling
Dignam JP, Perez-Ternero C, Aubdool AA, Hobbs AJ
 
01-05-2023
C-type Natriuretic Peptide Attenuates Endothelial and Cardiac Dysfunction During Endotoxemia and Polymicrobial Sepsis
Moyes A, Sand C, Aubdool A, Perez-Ternero C, Mohammad S, Thiemermann C, Hobbs A
American Thoracic Society 2023 International Conference, May 19-24, 2023 - Washington, DC. 
01-05-2023
Receptor guanylyl cyclase (RGC) family in GtoPdb v.2023.1
Beuve A, Brouckaert P, Burnett, Jr. JC, Friebe A, Garthwaite J, Hobbs AJ, Koesling D, Kuhn M et al.
Iuphar/Bps Guide to Pharmacology Cite, Edinburgh University Library vol. 2023 (1) 
26-04-2023
C-type natriuretic peptide regulates metabolic homeostasis
Perez-Ternero C, Aubdool A, Makwana R, Sanger G, Stimson R, Chan L, Moyes A, Hobbs A
 
31-01-2023
C-type natriuretic peptide offsets the development of pulmonary hypertension
Dignam JP, Perez-Ternero C, Aubdool A, Hobbs AJ
 
31-01-2023
Small molecules enhance natriuretic peptide activity through a novel allosteric site on the natriuretic peptide receptor guanylyl cyclase-A
Andresen H, Perez-Ternero C, Robinson J, Dickey D, Hobbs A, Potter LR, Levy FO, Cataliotti A et al.
 
31-01-2023
C-type natriuretic peptide regulates metabolic homeostasis
Perez-Ternero C, Aubdool A, Makwana R, Sanger G, Stimson R, Chan L, Moyes A, Hobbs A
 
01-01-2023
C-type natriuretic peptide offsets the development of pulmonary hypertension
Dignam JP, Perez-Ternero C, Aubdool A, Hobbs AJ
 
01-01-2023
Small molecules enhance natriuretic peptide activity through a novel allosteric site on the natriuretic peptide receptor guanylyl cyclase-A
Andresen H, Perez-Ternero C, Robinson J, Dickey D, Hobbs A, Potter LR, Levy FO, Cataliotti A et al.
 
01-01-2023
C-type natriuretic peptide protects against the development of non-alcoholic steatohepatitis and portal hypertension
Perez-Ternero C, Li W, Aubdool A, Goldin R, Alazawi W, Hobbs A
 
01-01-2023

2022

C-type natriuretic peptide preserves central neurological function by maintaining blood-brain barrier integrity
Perez Ternero C, Pallier PN, Tremoleda JL, Delogu A, Fernandes C, Michael-Titus AT, Hobbs AJ
Frontiers in Molecular Neuroscience, Frontiers vol. 15, 991112-991112.  
04-10-2022
The reaction of hydropersulfides (RSSH) with S-nitrosothiols (RS-NO) and the biological/physiological implications
Zarenkiewicz J, Perez-Ternero C, Kojasoy V, McGinity C, Khodade VS, Lin J, Tantillo DJ, Toscano JP et al.
Free Radical Biology and Medicine, Elsevier Bv vol. 188, 459-467.  
01-08-2022
C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis
Perez-Ternero C, Aubdool AA, Makwana R, Sanger GJ, Stimson RH, Chan LF, Moyes AJ, Hobbs AJ
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 119 (13) 
25-03-2022
A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C
Smith RJ, Perez-Ternero C, Conole D, Martin C, Myers SH, Hobbs AJ, Selwood DL
Journal of Medicinal Chemistry, American Chemical Society (Acs) vol. 65 (7), 5495-5513.  
25-03-2022
Astrocyte mitochondria produce nitric oxide from nitrite to modulate cerebral blood flow during brain hypoxia
Christie IN, Theparambil SM, Doronin M, Hosford PS, Brazhe A, Hobbs A, Semyanov A, Abramov AY et al.
In Cold Spring Harbor Laboratory 
14-03-2022
Hydropersulfides (RSSH) and Nitric Oxide (NO) Signaling: Possible Effects on S-Nitrosothiols (RS-NO)
Fukuto JM, Perez-Ternero C, Zarenkiewicz J, Lin J, Hobbs AJ, Toscano JP
Antioxidants, Mdpi Ag vol. 11 (1), 169-169.  
16-01-2022
Novel enhancers of guanylyl cyclase-A activity via allosteric modulation
Andresen H, Pérez-Ternero C, Robinson J, Dickey DM, Hobbs AJ, Potter LR, Levy FO, Cataliotti A et al.
In Cold Spring Harbor Laboratory 
01-01-2022

2021

Innovative Anti-Inflammatory and Pro-resolving Strategies for Pulmonary Hypertension: High Blood Pressure Research Council of Australia Award 2019
Scott TE, Qin CX, Drummond GR, Hobbs AJ, Kemp-Harper BK
Hypertension, Ovid Technologies (Wolters Kluwer Health) vol. 78 (5), 1168-1184.  
01-11-2021
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors
Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E et al.
British Journal of Pharmacology, Wiley vol. 178 (S1) 
16-09-2021
Receptor guanylyl cyclase (RGC) family in GtoPdb v.2021.3
Beuve A, Brouckaert P, Burnett, Jr. JC, Friebe A, Garthwaite J, Hobbs AJ, Koesling D, Kuhn M et al.
Iuphar/Bps Guide to Pharmacology Cite, Edinburgh University Library vol. 2021 (3) 
02-09-2021
Cyclic GMP modulating drugs in cardiovascular diseases: mechanism-based network pharmacology
Petraina A, Nogales C, Krahn T, Mucke H, Lüscher TF, Fischmeister R, Kass DA, Burnett JC et al.
Cardiovascular Research, Oxford University Press (Oup) vol. 118 (9), 2085-2102.  
16-07-2021
Multidrug resistance proteins preferentially regulate natriuretic peptide‐driven cGMP signalling in the heart and vasculature
Grange RMH, Preedy MEJ, Renukanthan A, Dignam JP, Lowe VJ, Moyes AJ, Pérez‐Ternero C, Aubdool AA et al.
British Journal of Pharmacology, Wiley vol. 179 (11), 2443-2459.  
13-07-2021
Animal models of pulmonary hypertension: Getting to the heart of the problem
Dignam JP, Scott TE, Kemp‐Harper BK, Hobbs AJ
British Journal of Pharmacology, Wiley vol. 179 (5), 811-837.  
12-05-2021
A comparison of the chemical biology of hydropersulfides (RSSH) with other protective biological antioxidants and nucleophiles
Fukuto JM, Hobbs AJ
Nitric Oxide, Elsevier Bv vol. 107, 46-57.  
01-02-2021

2020

Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia
Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S et al.
Journal of Molecular Medicine, Springer Science and Business Media Llc 
06-07-2020
Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti‐platelet therapy
Armstrong PC, Ferreira PM, Chan MV, Lundberg Slingsby MH, Crescente M, Shih C, Kirkby NS, Hobbs AJ et al.
Journal of Thrombosis and Haemostasis, Elsevier Bv vol. 18 (7), 1705-1713.  
01-07-2020
Receptor guanylyl cyclase (RGC) family (version 2020.3) in the IUPHAR/BPS Guide to Pharmacology Database
Beuve A, Brouckaert P, Burnett, Jr. JC, Friebe A, Garthwaite J, Hobbs AJ, Koesling D, Kuhn M et al.
Iuphar/Bps Guide to Pharmacology Cite, Edinburgh University Library vol. 2020 (3) 
19-06-2020
Multiplicity of Nitric Oxide and Natriuretic Peptide Signaling in Heart Failure
Preedy MEJ, Baliga RS, Hobbs AJ
Journal of Cardiovascular Pharmacology, Ovid Technologies (Wolters Kluwer Health) vol. 75 (5), 370-384.  
01-05-2020
Targeting the NLRP3 Inflammasome as a Novel Approach to Treat Pulmonary Hypertension
Scott TE, Ung V, Baliga RS, Robertson AAB, Nold-Petry CA, Nold MF, Drummond GR, Hobbs AJ et al.
American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. 
01-05-2020

2019

Repurposing an anti‐cancer agent for the treatment of hypertrophic heart disease
Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J et al.
The Journal of Pathology, Wiley vol. 249 (4), 523-535.  
30-10-2019
Receptor guanylyl cyclase (RGC) family (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Beuve A, Brouckaert P, Burnett, Jr. JC, Friebe A, Garthwaite J, Hobbs AJ, Koesling D, Kuhn M et al.
Iuphar/Bps Guide to Pharmacology Cite, Edinburgh University Library vol. 2019 (4) 
16-09-2019
Nitric oxide biology & pathobiology (3rd edition) editors: Louis Ignarro & Bruce Freeman
Hobbs AJ
Nitric Oxide, Elsevier Bv vol. 90, 66-66.  
01-09-2019
C-Type Natriuretic Peptide: A Multifaceted Paracrine Regulator in the Heart and Vasculature
Moyes AJ, Hobbs AJ
International Journal of Molecular Sciences, Mdpi Ag vol. 20 (9), 2281-2281.  
08-05-2019
Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double‐blind, placebo‐controlled, proof‐of‐concept trial
Hobbs AJ, Moyes AJ, Baliga RS, Ghedia D, Ochiel R, Sylvestre Y, Doré CJ, Chowdhury K et al.
British Journal of Pharmacology, Wiley vol. 176 (9), 1251-1267.  
31-03-2019
Endothelial C-Type Natriuretic Peptide Is a Critical Regulator of Angiogenesis and Vascular Remodeling
Bubb KJ, Aubdool AA, Moyes AJ, Lewis S, Drayton JP, Tang O, Mehta V, Zachary IC et al.
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 139 (13), 1612-1628.  
26-03-2019
C-type natriuretic peptide co-ordinates cardiac structure and function
Moyes AJ, Chu SM, Aubdool AA, Dukinfield MS, Margulies KB, Bedi KC, Hodivala-Dilke K, Baliga RS et al.
European Heart Journal, Oxford University Press (Oup) vol. 41 (9), 1006-1020.  
21-03-2019
Correction to: Soluble Guanylate Cyclase Stimulators and Activators
Sandner P, Zimmer DP, Milne GT, Follmann M, Hobbs A, Stasch J-P
, Springer International Publishing, 425-425.  
01-01-2019
C-Type Natriuretic Peptide (CNP) Regulates Adipogenesis, Thermogenesis and Glucose Sensitivity via Natriuretic Peptide Receptor (NPR)-C Signalling
Perez-Ternero C, Aubdool AA, Moyes AJ, Hobbs AJ
 
01-01-2019

2018

Biophysical screening methods for extracellular domain peptide receptors, application to natriuretic peptide receptor C ligands
Conole D, Myers SH, Mota F, Hobbs AJ, Selwood DL
Chemical Biology &Amp; Drug Design, Wiley vol. 93 (6), 1011-1020.  
10-10-2018
Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure
Baliga RS, Preedy MEJ, Dukinfield MS, Chu SM, Aubdool AA, Bubb KJ, Moyes AJ, Tones MA et al.
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 115 (31) 
16-07-2018
Inflammasomes: a novel therapeutic target in pulmonary hypertension?
Scott TE, Kemp‐Harper BK, Hobbs AJ
British Journal of Pharmacology, Wiley vol. 176 (12), 1880-1896.  
27-06-2018
Angiotensin II Promotes K\n V\n 7.4 Channels Degradation Through Reduced Interaction With HSP90 (Heat Shock Protein 90)
Barrese V, Stott JB, Figueiredo HB, Aubdool AA, Hobbs AJ, Jepps TA, McNeish AJ, Greenwood IA
Hypertension, Ovid Technologies (Wolters Kluwer Health) vol. 71 (6), 1091-1100.  
01-06-2018
Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology
Fukuto JM, Ignarro LJ, Nagy P, Wink DA, Kevil CG, Feelisch M, Cortese‐Krott MM, Bianco CL et al.
Febs Letters, Wiley vol. 592 (12), 2140-2152.  
24-05-2018
Potent Anti‐Inflammatory and Pro‐Resolving Effects of Anabasum in a Human Model of Self‐Resolving Acute Inflammation
Motwani MP, Bennett F, Norris PC, Maini AA, George MJ, Newson J, Henderson A, Hobbs AJ et al.
Clinical Pharmacology &Amp; Therapeutics, Wiley vol. 104 (4), 675-686.  
30-01-2018
Soluble Guanylate Cyclase Stimulators and Activators
Sandner P, Zimmer DP, Milne GT, Follmann M, Hobbs A, Stasch J-P
, Springer International Publishing, 355-394.  
01-01-2018

2017

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview
Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL et al.
British Journal of Pharmacology, Wiley vol. 174 (S1) 
21-10-2017
The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle
Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R et al.
Human Molecular Genetics, Oxford University Press (Oup) vol. 27 (1), 199-210.  
10-10-2017
Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications
Todd Milne G, Sandner P, Lincoln KA, Harrison PC, Chen H, Wang H, Clifford H, Qian HS et al.
Bmc Pharmacology and Toxicology, Springer Science and Business Media Llc vol. 18 (S1) 
01-10-2017

2016

Functional pharmacological characterization of SER100 in cardiovascular health and disease
Villar IC, Bubb KJ, Moyes AJ, Steiness E, Gulbrandsen T, Levy FO, Hobbs AJ
British Journal of Pharmacology, Wiley vol. 173 (23), 3386-3401.  
01-11-2016
[OP.7C.08] BLOOD-PRESSURE ASSOCIATED VARIANTS IN NPR3 AFFECT HUMAN VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION AND CALCIUM RESPONSE TO ANGIOTENSIN II
Ren M, Ng F, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al.
 
01-09-2016
A Janus-Faced Role for Atrial Natriuretic Peptide in Myocardial Infarction?
Hobbs AJ
Circulation Research, Ovid Technologies (Wolters Kluwer Health) vol. 119 (2), 181-183.  
08-07-2016
Guanylyl cyclase can't stand the HETE
Hobbs AJ
American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society vol. 310 (11), H1608-H1610.  
01-06-2016
IκB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD

Journal of The American Society of Nephrology, Ovid Technologies (Wolters Kluwer Health) vol. 28 (1), 94-105.  
06-05-2016
Raised arterial blood pressure in neurokinin‐1 receptor‐deficient mice (NK1R−/−): evidence for a neural rather than a vascular mechanism
Moyes AJ, Stanford SC, Hosford PS, Hobbs AJ, Ramage AG
Experimental Physiology, Wiley vol. 101 (5), 588-598.  
09-04-2016
Clinical relevance of cyclic GMP modulators: A translational success story of network pharmacology
Oettrich JM, Dao VT, Frijhoff J, Kleikers PWM, Casas AI, Hobbs AJ, Schmidt HHHW
Clinical Pharmacology &Amp; Therapeutics, Wiley vol. 99 (4), 360-362.  
13-02-2016
The nuances of NO synthase regulation in sepsis: Could targeting BH4 be the answer?
Sand CA, Hobbs AJ
Vascular Pharmacology, Elsevier Bv vol. 77, 35-37.  
01-02-2016
Therapeutic Proof-Of-Concept For Novel Sirna Technology In Experimental Pulmonary Hypertension
Baliga RS, Moyes AJ, Villar IC, Schaeper U, Iannone L, Hobbs AJ
 
01-01-2016

2015

Abstract 19478: Endothelial and Cardiomyocyte -derived C-type Natriuretic Peptide Coordinate Heart Structure and Function
Moyes AJ, Chu SM, Baliga RS, Hobbs AJ
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 132 (suppl_3) 
10-11-2015
C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytes
Peake NJ, Bader DL, Vessillier S, Ramachandran M, Salter DM, Hobbs AJ, Chowdhury TT
Biochemical and Biophysical Research Communications, Elsevier Bv vol. 465 (4), 784-789.  
01-10-2015
Investigation of the role of multidrug resistance proteins (MRPs) in vascular homeostasis
Allen RMH, Renukanthan A, Bubb KJ, Villar IC, Moyes AJ, Baliga RS, Hobbs AJ
Bmc Pharmacology and Toxicology, Springer Science and Business Media Llc vol. 16 (S1) 
02-09-2015
Pivotal vascular homeostatic role for endothelium-derived C-type natriuretic peptide (CNP)
Hobbs AJ
Bmc Pharmacology and Toxicology, Springer Science and Business Media Llc vol. 16 (S1) 
02-09-2015
Abstract P048: Blood-Pressure Associated Variants in Natriuretic Peptide Receptor C Affect Human Vascular Smooth Muscle Cells Proliferation and Calcium Flux in Response to Angiotensin II
Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al.
Hypertension, Ovid Technologies (Wolters Kluwer Health) vol. 66 (suppl_1) 
01-09-2015
Bile duct‐ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences
O'Brien A, China L, Massey KA, Nicolaou A, Winstanley A, Newson J, Hobbs A, Audzevich T et al.
Liver International, Wiley vol. 36 (6), 837-846.  
22-06-2015
PP.LB03.07
Ren M, Ng F, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al.
 
01-06-2015
Polyelectrolyte microencapsules loaded with C-type natriuretic peptide protect cartilage from IL-1B induced damage
Peake N, Pavlov A, D'Souza A, Alfasahin I, Pingaan-Murphy B, Sukhurukov G, Hobbs A, Chowdhury T
Osteoarthritis and Cartilage, Elsevier Bv vol. 23, A141-A142.  
01-04-2015
Investigation of the Role of Multidrug Resistance Proteins (MRPs) in Vascular Homeostasis
Allen R, Renukanthan A, Bubb K, Villar I, Moyes A, Baliga R, Hobbs A
The Faseb Journal, Wiley vol. 29 (S1) 
01-04-2015
Controlled Release of C-Type Natriuretic Peptide by Microencapsulation Dampens Proinflammatory Effects Induced by IL-1β in Cartilage Explants
Peake NJ, Pavlov AM, D’Souza A, Pingguan-Murphy B, Sukhorukov GB, Hobbs AJ, Chowdhury TT
Biomacromolecules, American Chemical Society (Acs) vol. 16 (2), 524-531.  
20-01-2015
Extending the translational potential of targeting NO/cGMP‐regulated pathways in the CVS
Papapetropoulos A, Hobbs AJ, Topouzis S
British Journal of Pharmacology, Wiley vol. 172 (6), 1397-1414.  
12-01-2015
Blood-pressure associated variants in NPR3 affect human vascular smooth muscle cells proliferation and calcium response to angiotensin II
Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al.
 
01-01-2015
Endothelial and Cardiomyocyte-derived C-type Natriuretic Peptide Coordinate Heart Structure and Function
Moyes AJ, Chu SM, Baliga RS, Hobbs AJ
 
01-01-2015
Modulation of cGMP Synthesis and Metabolism
Bubb KJ, Hobbs AJ, Klinger JR
In Respiratory Medicine, Springer New York 355-375.  
01-01-2015

2014

Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: Implications of their possible biological activity and utility
Ono K, Akaike T, Sawa T, Kumagai Y, Wink DA, Tantillo DJ, Hobbs AJ, Nagy P et al.
Free Radical Biology and Medicine, Elsevier Bv vol. 77, 82-94.  
01-12-2014
Role of C-type natriuretic peptide signalling in maintaining cartilage and bone function
Peake NJ, Hobbs AJ, Pingguan-Murphy B, Salter DM, Berenbaum F, Chowdhury TT
Osteoarthritis and Cartilage, Elsevier Bv vol. 22 (11), 1800-1807.  
01-11-2014
Endothelial C-type natriuretic peptide maintains vascular homeostasis
Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ et al.
Journal of Clinical Investigation, American Society For Clinical Investigation vol. 124 (9), 4039-4051.  
08-08-2014
Inhibition of Phosphodiesterase 2 Augments cGMP and cAMP Signaling to Ameliorate Pulmonary Hypertension
Bubb KJ, Trinder SL, Baliga RS, Patel J, Clapp LH, MacAllister RJ, Hobbs AJ
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 130 (6), 496-507.  
05-08-2014
Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ
British Journal of Pharmacology, Wiley vol. 171 (14), 3463-3475.  
25-06-2014
Light-triggered carbon monoxide delivery with Al-MCM-41-based nanoparticles bearing a designed manganese carbonyl complex
Gonzales MA, Han H, Moyes A, Radinos A, Hobbs AJ, Coombs N, Oliver SRJ, Mascharak PK
Journal of Materials Chemistry B, Royal Society of Chemistry (Rsc) vol. 2 (15), 2107-2107.  
01-01-2014
Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo model
Peake N, Su N, Ramachandran M, Achan P, Salter DM, Bader DL, Moyes AJ, Hobbs AJ et al.
 
01-01-2014

2013

Natriuretic peptide receptors and heart failure: to B or not to B blocked?
Hobbs AJ
Naunyn-Schmiedeberg's Archives of Pharmacology, Springer Science and Business Media Llc vol. 387 (1), 1-4.  
06-12-2013
The Concise Guide to PHARMACOLOGY 2013/14: Overview
Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M et al.
British Journal of Pharmacology, Wiley vol. 170 (8), 1449-1458.  
01-12-2013
Endothelial Injury in a Transforming Growth Factor β–Dependent Mouse Model of Scleroderma Induces Pulmonary Arterial Hypertension
Derrett‐Smith EC, Dooley A, Gilbane AJ, Trinder SL, Khan K, Baliga R, Holmes AM, Hobbs AJ et al.
Arthritis &Amp; Rheumatism, Wiley vol. 65 (11), 2928-2939.  
28-10-2013
Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model
Peake N, Su N, Ramachandran M, Achan P, Salter DM, Bader DL, Moyes AJ, Hobbs AJ et al.
Arthritis Research &Amp; Therapy, Springer Science and Business Media Llc vol. 15 (4) 
24-07-2013
C2238 Atrial Natriuretic Peptide Molecular Variant Is Associated With Endothelial Damage and Dysfunction Through Natriuretic Peptide Receptor C Signaling
Sciarretta S, Marchitti S, Bianchi F, Moyes A, Barbato E, Di Castro S, Stanzione R, Cotugno M et al.
Circulation Research, Ovid Technologies (Wolters Kluwer Health) vol. 112 (10), 1355-1364.  
10-05-2013
Enhanced Vasodilator Activity of Nitrite in Hypertension
Ghosh SM, Kapil V, Fuentes-Calvo I, Bubb KJ, Pearl V, Milsom AB, Khambata R, Maleki-Toyserkani S et al.
Hypertension, Ovid Technologies (Wolters Kluwer Health) vol. 61 (5), 1091-1102.  
01-05-2013
Letter by Ahluwalia and Hobbs Regarding Article, “Nitrate-Nitrite-Nitric Oxide Pathway in Pulmonary Arterial Hypertension Therapeutics”
Ahluwalia A, Hobbs AJ
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 127 (2) 
15-01-2013
Validation Of Phosphodiesterase 2 As A Novel Therapeutic Target In Pulmonary Hypertension
Bubb KJ, Trinder S, Baliga R, MacAllister RJ, Hobbs AJ
 
01-01-2013
Vasoactive Peptides and the Pathogenesis of Pulmonary Hypertension: Role and Potential Therapeutic Application
Baliga RS, MacAllister RJ, Hobbs AJ
In Handbook of Experimental Pharmacology, Springer Berlin Heidelberg 477-511.  
01-01-2013

2012

Distinct endothelial pathways underlie sexual dimorphism in vascular auto‐regulation
Chan MV, Bubb KJ, Noyce A, Villar IC, Duchene J, Hobbs AJ, Scotland RS, Ahluwalia A
British Journal of Pharmacology, Wiley vol. 167 (4), 805-817.  
25-09-2012
Dietary Nitrate Ameliorates Pulmonary Hypertension
Baliga RS, Milsom AB, Ghosh SM, Trinder SL, MacAllister RJ, Ahluwalia A, Hobbs AJ
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 125 (23), 2922-2932.  
12-06-2012
Dietary Nitrate: A Novel Therapy For Pulmonary Hypertension
Baliga RS, Milsom AB, Trinder SL, Ghosh S, MacAllister RJ, Ahluwalia A, Hobbs AJ
American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. 
01-05-2012
SYSTEMIC VEGF INHIBITION INDUCES PULMONARY ARTERIAL HYPERTENSION IN A TRANSGENIC MOUSE MODEL OF SCLERODERMA
Derrett-Smith E, Dooley A, Baliga R, Hobbs A, Abraham D, Denton C
 
01-01-2012
Accelerated Atherogenesis and Diminished Vascular Integrity in Mice Lacking Endothelial C-Type Natriuretic Peptide
Moyes AJ, Khambata RS, Ahluwalia A, Hobbs AJ
Circulation vol. 126 (21) 
01-01-2012

2011

Manganese Carbonyls Bearing Tripodal Polypyridine Ligands as Photoactive Carbon Monoxide-Releasing Molecules
Gonzalez MA, Yim MA, Cheng S, Moyes A, Hobbs AJ, Mascharak PK
Inorganic Chemistry, American Chemical Society (Acs) vol. 51 (1), 601-608.  
09-12-2011
Natriuretic peptide receptor-3 underpins the disparate regulation of endothelial and vascular smooth muscle cell proliferation by C-type natriuretic peptide
Khambata RS, Panayiotou CM, Hobbs AJ
Brit J Pharmacol vol. 164 (2B), 584-597.  
01-09-2011
LXR alpha Regulates Macrophage Arginase 1 Through PU.1 and Interferon Regulatory Factor 8
Pourcet B, Feig JE, Vengrenyuk Y, Hobbs AJ, Kepka-Lenhart D, Garabedian MJ, Morris SM, Fisher EA et al.
Circ Res vol. 109 (5), 492-U105.  
19-08-2011
Enhancing natriuretic peptide bioactivity prevents bleomycin-induced pulmonary fibrosis
Baliga RS, Trinder SL, Scotton CJ, Chambers RC, MacAllister RJ, Hobbs AJ
Bmc Pharmacology, Springer Science and Business Media Llc vol. 11 (S1) 
01-08-2011
Design and development of novel non-peptide agonists at NPR-C
Quinteiro FM, Gane P, Rebstock A-S, Worthington R, Simone M, Djordevic S, Hobbs A, Selwood D
Bmc Pharmacology, Springer Science and Business Media Llc vol. 11 (S1) 
01-08-2011
Suppression of Endothelial P-Selectin Expression Contributes to Reduced Cell Trafficking in Females An Effect Independent of NO and Prostacyclin
Villar IC, Scotland RS, Khambata RS, Chan M, Duchene J, Sampaio AL, Perretti M, Hobbs AJ et al.
Arterioscl Throm Vas vol. 31 (5), 1075-1083.  
01-05-2011
P54. Dietary nitrate attenuates platelet reactivity: Role of the erythrocyte and influence of sex
Velmurugan S, Kapil V, McKnight AHO, Aboud Z, Davies S, Milsom AB, Pearl V, Liverani E et al.
 
01-05-2011
New perspectives for the treatment of pulmonary hypertension
Baliga RS, MacAllister RJ, Hobbs AJ
Brit J Pharmacol vol. 163 (1), 125-140.  
01-05-2011
Protective Role Of Natriuretic Peptides In Pulmonary Fibrosis: A Novel Therapeutic Target?
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ
American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. 
01-05-2011
Designed Iron Carbonyls as Carbon Monoxide (CO) Releasing Molecules: Rapid CO Release and Delivery to Myoglobin in Aqueous Buffer, and Vasorelaxation of Mouse Aorta
Gonzalez MA, Fry NL, Burt R, Davda R, Hobbs A, Mascharak PK
Inorganic Chemistry, American Chemical Society (Acs) vol. 50 (7), 3127-3134.  
04-04-2011
Response to Inorganic Nitrate for Blood Pressure Lowering?
Kapil V, Benjamin N, Hobbs A, Ahluwalia A
Hypertension, Ovid Technologies (Wolters Kluwer Health) vol. 57 (2) 
01-02-2011
AN EXPLORATION OF PULMONARY VASCULAR VEGF SIGNALLING IN A TGFβ-DEPENDENT MOUSE MODEL OF SYSTEMIC SCLEROSIS
Derrett-Smith EC, Dooley A, Baliga R, Hobbs A, MacAllister R, Abraham D, Denton C
 
01-01-2011
Intermittent Systemic VEGF Inhibition Induces Pulmonary Arterial Hypertension In a Transgenic Mouse Model of Scleroderma
Derrett-Smith E, Dooley A, Baliga R, Hobbs A, Abraham DJ, Denton CP
 
01-01-2011

2010

C-type Natriuretic Peptide (CNP): Cardiovascular Roles and Potential as a Therapeutic Target
Lumsden NG, Khambata RS, Hobbs AJ
Curr Pharm Design vol. 16 (37), 4080-4088.  
01-12-2010
Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury
Madhani M, Hall AR, Cuello F, Charles RL, Burgoyne JR, Fuller W, Hobbs AJ, Shattock MJ et al.
American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society vol. 299 (3), H827-H836.  
01-09-2010
Inorganic Nitrate Supplementation Lowers Blood Pressure in Humans Role for Nitrite-Derived NO
Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, Arghandawi S, Pearl V et al.
Hypertension vol. 56 (2), 274-U174.  
01-08-2010
Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A
Panayiotou CM, Baliga R, Stidwill R, Taylor V, Singer M, Hobbs AJ
Brit J Pharmacol vol. 160 (8), 2045-2054.  
01-08-2010
The anti‐atherogenic potential of C‐type natriuretic peptide: Disparate regulation of endothelial and vascular smooth muscle cell proliferation via natriuretic peptide receptor‐C
Khambata RS, Panayiotou CM, Xiao F, Hobbs AJ
The Faseb Journal, Wiley vol. 24 (S1) 
01-04-2010
Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischemia–reperfusion injury in mice
Milsom AB, Patel NSA, Mazzon E, Tripatara P, Storey A, Mota-Filipe H, Sepodes B, Webb AJ et al.
 
01-02-2010
Perturbed VEGF signalling within the pulmonary vasculature of a TGFβ dependent mouse model of systemic sclerosis
Derrett-Smith EC, Dooley A, Baliga R, Hobbs A, MacAllister R, Abraham D, Denton CP
Clinical and Experimental Rheumatology vol. 28 (5), S63-S63.  
01-01-2010
C-type Natriuretic Peptide (CNP): Cardiovascular Roles and Potential as a Therapeutic Target
Lumsden NG, Khambata RS, Hobbs AJ
Current Pharmaceutical Design vol. 16 (37), 4080-4088.  
01-01-2010
Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischemia-reperfusion injury in mice
Milsom AB, Patel NSA, Mazzon E, Tripatara P, Storey A, Mota-Filipe H, Sepodes B, Webb AJ et al.
Nitric Oxide-Biology and Chemistry vol. 22 (2), 141-148.  
01-01-2010
Soluble Guanylate Cyclase
Hobbs AJ, Stasch J-P
In Nitric Oxide, Elsevier 301-326.  
01-01-2010
Soluble Guanylate Cyclase. Allosteric Activation and Redox Regulation.
Hobbs AJ, Stasch JP
In Nitric Oxide 301-326.  
01-01-2010
Oral inorganic nitrate lowers blood pressure in healthy male, but not female, volunteers, via bioconversion to nitrite
Kapil V, Maleki-Toyserkani S, Rehman F, Arghandawi S, Pearl V, Milsom A, Benjamin N, Hobbs A et al.
 
01-01-2010

2009

Laminar Shear Stress Regulates Endothelial Kinin B1 Receptor Expression and Function Potential Implication in Atherogenesis
Duchene J, Cayla C, Vessillier S, Scotland R, Yamashiro K, Lecomte F, Syed I, Vo P et al.
Arterioscl Throm Vas vol. 29 (11), 1757-1763.  
01-11-2009
The Effects of Nitroxyl (HNO) on Soluble Guanylate Cyclase Activity
Miller TW, Cherney MM, Lee AJ, Francoleon NE, Farmer PJ, King SB, Hobbs AJ, Miranda KM et al.
Journal of Biological Chemistry, Elsevier Bv vol. 284 (33), 21788-21796.  
01-08-2009
Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans
Morris T, Stables M, Hobbs A, de Souza P, Colville-Nash P, Warner T, Newson J, Bellingan G et al.
The Journal of Immunology, Oxford University Press (Oup) vol. 183 (3), 2089-2096.  
01-08-2009
Manipulating the natriuretic peptide system for the treatment of pulmonary hypertension
Baliga RS, Trinder S, Scotton CJ, Chambers RC, MacAllister RJ, Hobbs AJ
Bmc Pharmacology, Springer Science and Business Media Llc vol. 9 (S1) 
01-08-2009
Design and development of novel non‐peptide agonists at natriuretic peptide receptor‐C
Hobbs AJ, Gane P, Lumsden N, Nobles M, Rebstock A, Simone M, Villar I, Worthington R et al.
The Faseb Journal, Wiley vol. 23 (S1) 
01-04-2009
Response to Letter Regarding Article, “Circulating Endothelial Progenitor Cells in Patients With Eisenmenger Syndrome and Idiopathic Pulmonary Arterial Hypertension”
Diller G-P, Bédard E, Wort SJ, Gatzoulis MA, van Eijl S, Ali O, Wilkins MR, Wharton J et al.
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 119 (9) 
10-03-2009
Involvement of Fibroblast growth factor 10 (Fgf10) in the anterior-posterior patterning and specification of muscle and tendon progenitors in the developing mouse limbs
Hajihosseini MK, Ramasamy S, De Langhe S, Lana-Elola E, Rice D, Rio LQ, Kelly R, Sharpe J et al.
Faseb Journal vol. 23 
01-01-2009
Oral inorganic nitrate lowers blood pressure and protects against endothelial ischaemia-reperfusion injury in humans
Kapil V, Okorie M, Akram F, Rehman F, Milsom A, Arghandawi S, Pearl V, Deanfield J et al.
 
01-01-2009
BLOOD PRESSURE LOWERING EFFECTS OF ORAL INORGANIC NITRATE VIA BIOCONVERSION TO NITRITE
Kapil V, Rehman F, Arghandawi S, Milsom A, Benjamin N, Hobbs A, MacAllister R, Webb A et al.
Basic & Clinical Pharmacology & Toxicology vol. 105, 31-31.  
01-01-2009
ORAL INORGANIC NITRATE PROTECTS AGAINST ENDOTHELIAL ISCHAEMIA-REPERFUSION INJURY IN HUMANS
Okorie M, Akram F, Loukogeorgakis S, Webb A, Deanfield J, Benjamin N, Hobbs A, MacAllister R et al.
Basic & Clinical Pharmacology & Toxicology vol. 105, 26-26.  
01-01-2009

2008

Mechanisms Underlying Erythrocyte and Endothelial Nitrite Reduction to Nitric Oxide in Hypoxia Role for Xanthine Oxidoreductase and Endothelial Nitric Oxide Synthase
Webb AJ, Milsom AB, Rathod KS, Chu WL, Qureshi S, Lovell MJ, Lecomte FMJ, Perrett D et al.
Circ Res vol. 103 (9), 957-U114.  
24-10-2008
Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension
Baliga RS, Zhao L, Madhani M, Lopez-Torondel B, Visintin C, Selwood D, Wilkins MR, MacAllister RJ et al.
Am J Resp Crit Care vol. 178 (8), 861-869.  
15-10-2008
Characterization of the Human α1β1 Soluble Guanylyl Cyclase Promoter
Marro ML, Peiró C, Panayiotou CM, Baliga RS, Meurer S, Schmidt HHHW, Hobbs AJ
Journal of Biological Chemistry, Elsevier Bv vol. 283 (29), 20027-20036.  
01-07-2008
Circulating Endothelial Progenitor Cells in Patients With Eisenmenger Syndrome and Idiopathic Pulmonary Arterial Hypertension
Diller G-P, van Eijl S, Okonko DO, Howard LS, Ali O, Thum T, Wort SJ, Bédard E et al.
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 117 (23), 3020-3030.  
10-06-2008
Sex differences in vascular function: implication of endothelium-derived hyperpolarizing factor
Villar IC, Hobbs AJ, Ahluwalia A
Journal of Endocrinology, Bioscientifica vol. 197 (3), 447-462.  
01-06-2008
Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFNγ-dependent iNOS expression in the vasculature of healthy mice
Morton J, Coles B, Wright K, Gallimore A, Morrow JD, Terry ES, Anning PB, Morgan BP et al.
Blood, American Society of Hematology vol. 111 (10), 5187-5194.  
15-05-2008
Resistance to endotoxic shock in mice lacking natriuretic peptide receptor‐A
Panayiotou CM, Stidwill R, Taylor V, Singer M, Hobbs AJ
The Faseb Journal, Wiley vol. 22 (S1) 
01-03-2008
Acute blood pressure lowering and vasoprotective effects of dietary nitrate
Webb A, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P et al.
The Faseb Journal, Wiley vol. 22 (S1) 
01-03-2008
Acute Blood Pressure Lowering, Vasoprotective, and Antiplatelet Properties of Dietary Nitrate via Bioconversion to Nitrite
Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P et al.
Hypertension, Ovid Technologies (Wolters Kluwer Health) vol. 51 (3), 784-790.  
01-03-2008
The enterosalivary bioconversion of nitrate to nitrite underlies the blood pressure (BP) lowering and anti-platelet effects of a dietary nitrate load
Aboud Z, Misra S, Warner T, Miall P, Benjamin N, Hobbs A, Webb A, Ahluwalia A
 
01-01-2008
Nitric oxide-induced relaxation in female resistance arteries is endothelium-dependent
Chan MV, Hobbs AJ, Scotland RS, Ahluwalia A
 
01-01-2008
P38. Endothelial nitric oxide synthase acts as a nitrite reductase in human endothelial cells
Milsom AB, Hobbs AJ, Ahluwalia A
 
01-01-2008

2007

NPR-A gene deletion reverses vascular dysfunction associated with sepsis
Panayiotou CM, Hobbs AJ
Bmc Pharmacology, Springer Science and Business Media Llc vol. 7 (S1) 
01-07-2007
Selective modulation of ANP-dependent dilatation in the pulmonary vasculature by PDE 5 inhibitors: a novel combination therapy for pulmonary hypertension?
Baliga RS, Zhao L, Wilkins MR, MacAllister RJ, Hobbs AJ
Bmc Pharmacology, Springer Science and Business Media Llc vol. 7 (S1) 
01-07-2007
Exploiting the natriuretic peptide system for the treatment of pulmonary hypertension
Hobbs AJ
Bmc Pharmacology, Springer Science and Business Media Llc vol. 7 (S1) 
01-07-2007
Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor
VILLAR I, PANAYIOTOU C, SHERAZ A, MADHANI M, SCOTLAND R, NOBLES M, KEMPHARPER B, AHLUWALIA A et al.
Cardiovascular Research, Oxford University Press (Oup) vol. 74 (3), 515-525.  
01-06-2007
The pharmacology of nitroxyl (HNO) and its therapeutic potential: Not just the janus face of NO11This review is dedicated to the career of Prof. Herbert T. Nagasawa, a pioneer in the field of HNO chemistry, biochemistry and pharmacology.
Paolocci N, Jackson MI, Lopez BE, Miranda K, Tocchetti CG, Wink DA, Hobbs AJ, Fukuto JM
Pharmacology &Amp; Therapeutics, Elsevier Bv vol. 113 (2), 442-458.  
01-02-2007
Selective modulation of ANP-dependent dilation in the pulmonary vasculature by PDE 5 inhibitors: A novel combination therapy for pulmonary hypertension?
Baliga R, Zhao L, Wilkins MR, MacAllister RJ, Hobbs AJ
 
01-01-2007
Acute blood pressure lowering and vasoprotective effects of beetroot juice: relationship to nitrite derived from dietary nitrate
Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Rashid R, Deanfield J, Benjamin N, Macallister R et al.
 
01-01-2007
Acute blood pressure (BP) lowering and vasoprotective effects of beetroot juice: relationship to nitrite derived from dietary nitrate
Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Rashid R, Deanfield J, Benjamin N, MacAllister R et al.
 
01-01-2007

2006

Biological activity of designed photolabile metal nitrosyls: Light-dependent activation of soluble guanylate cyclase and vasorelaxant properties in rat aorta
Madhani M, Patra AK, Miller TW, Eroy-Reveles AA, Hobbs AJ, Fukuto JM, Mascharak PK
J Med Chem vol. 49 (25), 7325-7330.  
14-12-2006
Reciprocal regulation of human soluble and particulate guanylate cyclases in vivo
Madhani M, Okorie M, Hobbs AJ, MacAllister RJ
Brit J Pharmacol vol. 149 (6), 797-801.  
01-11-2006
Novel aspects of endothelium-dependent regulation of vascular tone
Villar IC, Francis S, Webb A, Hobbs AJ, Ahluwalia A
Kidney International, Elsevier Bv vol. 70 (5), 840-853.  
01-09-2006
P067. Effect of changing redox status on the activation of soluble guanylate cyclase by nitrogen oxides
Miller TW, Franco NE, Hobbs AJ, Ignarro LJ, Fukuto JM
 
01-06-2006
Gender‐differences in leukocyte activation in vivo: role of endothelium‐derived mediators
Scotland RS, Duchene J, Hobbs A, Ahluwalia A
 
01-03-2006
Vascular inflammation modulates α1 and β1 soluble guanylate cyclase promoter activity in human aortic smooth muscle cells (HASMCs)
Marro M, Panayiotou C, Hobbs A
Acta Pharmacologica Sinica vol. 27, 172-172.  
01-01-2006
Distinct pathways regulate endothelium derived hyperpolarising factor-mediated responses in rat mesenteric arteries
Villar IC, Ahluwalia A, Hobbs AJ
Acta Pharmacologica Sinica vol. 27 (9), 1276-1276.  
01-01-2006
C-Type natriuretic peptide mediates ERK1/2 phosphorylation via Gi-coupled natriuretic peptide receptor-C in rat aortic smooth muscle cells
Panayiotou CM, Hobbs AJ
Acta Pharmacologica Sinica vol. 27, 170-170.  
01-01-2006

2005

C-type natriuretic peptide inhibits leukocyte recruitment and platelet-leukocyte interactions via suppression of P-selectin expression
Scotland RS, Cohen M, Foster P, Lovell M, Mathur A, Ahluwalia A, Hobbs AJ
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 102 (40), 14452-14457.  
22-09-2005
Characterisation of human a1 and b1 soluble guanylate cyclase promoter activity in human aortic smooth muscle cells
Marro ML, Hobbs AJ
Bmc Pharmacology, Springer Science and Business Media Llc vol. 5 (S1) 
01-06-2005
Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice - A pro-inflammatory role for eNOS-derived no in vivo
Connelly L, Madhani M, Hobbs AJ
J Biol Chem vol. 280 (11), 10040-10046.  
18-03-2005
Endothelium-derived C-type natriuretic peptide: more than just a hyperpolarizing factor
Ahluwalia A, Hobbs AJ
Trends in Pharmacological Sciences, Elsevier Bv vol. 26 (3), 162-167.  
01-03-2005
Investigation of Vascular Responses in Endothelial Nitric Oxide Synthase/Cyclooxygenase-1 Double-Knockout Mice
Scotland RS, Madhani M, Chauhan S, Moncada S, Andresen J, Nilsson H, Hobbs AJ, Ahluwalia A
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 111 (6), 796-803.  
15-02-2005
C-type natriuretic peptide in vascular physiology and disease
Scotland RS, Ahluwalia A, Hobbs AJ
Pharmacology &Amp; Therapeutics, Elsevier Bv vol. 105 (2), 85-93.  
01-02-2005
The natriuretic peptide receptor-C antagonist, M372049, blocks C-type natriuretic peptide and endothelium-derived hyperpolarizing factor-induced relaxation of resistance arteries
Ahluwalia A, Villar I, Scotland RS, Hobbs A
 
01-01-2005

2004

C-type natriuretic peptide: new candidate for endothelium-derived hyperpolarising factor
Chauhan SD, Hobbs AJ, Ahluwalia A
Int J Biochem Cell B vol. 36 (10), 1878-1881.  
01-10-2004
Natriuretic Peptide Receptor-C Regulates Coronary Blood Flow and Prevents Myocardial Ischemia/Reperfusion Injury
Hobbs A, Foster P, Prescott C, Scotland R, Ahluwalia A
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 110 (10), 1231-1235.  
07-09-2004
Vascular actions of natriuretic peptides - Cyclic GMP-dependent and -independent mechanisms
Ahluwalia A, MacAllister RJ, Hobbs AJ
Basic Res Cardiol vol. 99 (2), 83-89.  
01-03-2004
Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment
Ahluwalia A, Foster P, Scotland RS, McLean PG, Mathur A, Perretti M, Moncada S, Hobbs AJ
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 101 (5), 1386-1391.  
23-01-2004
Reciprocal interaction between soluble and particulate guanylate cyclases in vivo
Madhani M, MacAllister RJ, Hobbs AJ
 
01-01-2004
Endothelial nitric oxide synthase promotes inducible NOS expression in LPS-challenged mice in vivo
Connelly L, Hobbs AJ
 
01-01-2004
Endothelial C-type natriuretic peptide regulates coronary blood flow and prevents ischemia-reperfusion injury
Ahluwalia A, Foster P, Prescott C, Hobbs AJ
 
01-01-2004
Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury - Novel cardioprotective role for endothelium-derived C-type natriuretic peptide
Hobbs A, Foster P, Prescott C, Scotland R, Ahluwalia A
Circulation vol. 110 (10), 1231-1235.  
01-01-2004
C-type natriuretic peptide inhibits leukocyte recruitment in vivo via natriuretic peptide receptor-C activation
Scotland R, Foster P, Ahluwalia A, Hobbs AJ
 
01-01-2004

2003

Antiplatelet properties of a novel, non-NO-based soluble guanylate cyclase activator, BAY 41-2272
Hobbs AJ, Moncada S
Vasc Pharmacol vol. 40 (3), 149-154.  
01-10-2003
Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling
Madhani M, Scotland RS, MacAllister RJ, Hobbs AJ
Brit J Pharmacol vol. 139 (7), 1289-1296.  
01-08-2003
Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression
Connelly L, Jacobs AT, Palacios-Callender M, Moncada S, Hobbs AJ
J Biol Chem vol. 278 (29), 26480-26487.  
18-07-2003
Interactions between soluble guanylate cyclase and natriuretic peptide receptor-linked particulate guanylate cyclases in the mammalian vasculature
Madhani M, MacAllister R, Hobbs A
Bmc News and Views, Springer Science and Business Media Llc vol. 3 (S2) 
03-07-2003
BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro
Kalsi JS, Rees RW, Hobbs AJ, Royle M, Kell PD, Ralph DJ, Moncada S, Cellek S
J Urology vol. 169 (2), 761-766.  
01-02-2003
Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice
Chauhan SD, Seggara G, Vo PA, MacAllister RJ, Hobbs AJ, Ahluwalia A
Faseb J vol. 17 (2), 773-+.  
01-02-2003
BAY41-2272, a Novel Nitric Oxide Independent Soluble Guanylate Cyclase Activator, Relaxes Human and Rabbit Corpus Cavernosum In Vitro
KALSI JS, REES RW, HOBBS AJ, ROYLE M, KELL PD, RALPH DJ, MONCADA S, CELLEK S
The Journal of Urology, Ovid Technologies (Wolters Kluwer Health), 761-766.  
01-02-2003
Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor
Chauhan SD, Nilsson H, Ahluwalia A, Hobbs AJ
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 100 (3), 1426-1431.  
27-01-2003
Vascular natriuretic peptide receptors modulated by NO-cyclic GMP signalling
Madhani M, MacAllister R, Hobbs A
 
01-01-2003
Anti-leukocyte properties of a novel non NO-based soluble guanylate cyclase activator, BAY 41-2272
Foster P, Mathur A, McLean P, Perretti M, Moncada S, Ahluwalia A, Hobbs A
 
01-01-2003
Characterisation of eNOS/COX-1 double knockout mice: a novel model for the study of endothelium-derived hyperpolarising factor
Scotland RS, Chauhan SD, Hobbs AJ, Ahluwalia A
 
01-01-2003
Endothelium-derived hyperpolarising factor (EDHF) is C-type natriuretic peptide (CNP) in mesenteric resistance arteries
Hobbs AJ, Chauhan SD, Nilsson H, Ahluwalia A
 
01-01-2003

2002

Haemoglobin: NO transporter, NO inactivator or NOne of the above?
Hobbs AJ, Gladwin MT, Patel RP, Williams DLH, Butler AR
Trends in Pharmacological Sciences, Elsevier Bv vol. 23 (9), 406-411.  
01-09-2002
Soluble guanylate cyclase: an old therapeutic target re-visited
Hobbs AJ
Brit J Pharmacol vol. 136 (5), 637-639.  
01-07-2002
Haemoglobin: NO transporter, NO inactivator or NOne of the above?
Hobbs AJ, Gladwin MT, Patel RP, Williams DLH, Butler AR
Trends in Pharmacological Sciences vol. 23 (9), 406-411.  
01-01-2002
Mechanisms underlying the vasorelaxant activity of C-type natriuretic peptide (CNP) in rat mesenteric resistance arteries
Chauhan SD, MacAllister RJ, Hobbs AJ, Ahluwalia A
Faseb Journal vol. 16 (4), A572-A572.  
01-01-2002

2001

Biphasic regulation of NF-kappa B activity underlies the pro- and anti-inflammatory actions of nitric oxide
Connelly L, Palacios-Callender M, Ameixa C, Moncada S, Hobbs AJ
J Immunol vol. 166 (6), 3873-3881.  
15-03-2001
Reciprocal regulation of cGMP-mediated vasorelaxation by soluble and particulate guanylate cyclases
Hussain MB, MacAllister RJ, Hobbs AJ
Am J Physiol-Heart C vol. 280 (3), H1151-H1159.  
01-03-2001

2000

Soluble guanylate cyclase
Hobbs AJ
Emerging Therapeutic Targets, Informa Healthcare vol. 4 (6), 735-749.  
01-12-2000
Synthesis and Biological Evaluation of Novel Pyrazoles and Indazoles as Activators of the Nitric Oxide Receptor, Soluble Guanylate Cyclase
Selwood DL, Brummell DG, Budworth J, Burtin GE, Campbell RO, Chana SS, Charles IG, Fernandez PA et al.
Journal of Medicinal Chemistry, American Chemical Society (Acs) vol. 44 (1), 78-93.  
22-11-2000
Gastrointestinal motility during pregnancy: role of nitrergic component of NANC nerves
Shah S, Hobbs A, Singh R, Cuevas J, Ignarro LJ, Chaudhuri G
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, American Physiological Society vol. 279 (4), R1478-R1485.  
01-10-2000
Synthesis and biological evaluation of enantiopure thionitrites: The solid-phase synthesis and nitrosation of D-glutathione as a molecular probe
Cavero M, Hobbs A, Madge D, Motherwell WB, Selwood D, Potier P
Bioorg Med Chem Lett vol. 10 (7), 641-644.  
03-04-2000
Regulation of cGMP-mediated vasorelaxation in mouse thoracic aorta: Interactions of the soluble and particulate guanylate cyclases
Hussain MB, MacAllister RJ, Hobbs AJ
British Journal of Pharmacology vol. 129 
01-01-2000

1999

Autoregulation of nitric oxide-soluble guanylate cyclase-cyclic GMP signalling in mouse thoracic aorta
Hussain MB, Hobbs AJ, MacAllister RJ
Brit J Pharmacol vol. 128 (5), 1082-1088.  
01-11-1999
Biochemical characterization of S-nitrosohemoglobin - Mechanisms underlying synthesis, no release, and biological activity
Wolzt M, MacAllister RJ, Davis D, Feelisch M, Moncada S, Vallance P, Hobbs AJ
J Biol Chem vol. 274 (41), 28983-28990.  
08-10-1999
Chemistry and Molecular Biology of Nitric Oxide Synthesis
Hobbs AJ, Ignarro LJ
In The Haemodynamic Effects of Nitric Oxide, Published by Imperial College Press and Distributed by World Scientific Publishing Co. 52-81.  
01-08-1999
Inhibition of nitric oxide synthase as a potential therapeutic target
Hobbs AJ, Higgs A, Moncada S
Annu Rev Pharmacol vol. 39, 191-220.  
01-01-1999
Enhanced sensitivity of the soluble guanylate cyclase/cyclic GMP system in the eNOS knockout mouse
Hussain MB, Hobbs AJ, MacAllister RJ
British Journal of Pharmacology vol. 126, U41-U41.  
01-01-1999
Inducible nitric oxide synthase and inflammation
Hobbs AJ, Moncada S
In Inducible Enzymes in The Inflammatory Response, BirkhäUser Basel 31-54.  
01-01-1999

1997

Soluble guanylate cyclase: the forgotten sibling
Hobbs AJ
Trends in Pharmacological Sciences, Elsevier Bv vol. 18 (12), 484-491.  
01-12-1997
Soluble guanylate cyclase: the forgotten sibling
Hobbs AJ
Trends in Pharmacological Sciences, Elsevier Bv vol. 18 (4), 484-491.  
01-07-1997

1996

Nitric oxide regulates endothelium-dependent vasodilator responses in rabbit hindquarters vascular bed in vivo
Cohen GA, Hobbs AJ, Fitch RM, Zinner MJ, Chaudhuri G, Ignarro LJ
American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society vol. 271 (1), H133-H139.  
01-07-1996
[13] Nitric oxide-cyclic GMP signal transduction system
Hobbs AJ, Ignarro LJ
, Elsevier, 134-148.  
01-01-1996

1995

Enhanced actions of nitric oxide in modulating gastrointestinal smooth muscle function during pregnancy
Shah SN, Cuevas JM, Hobbs AJ, Whang E, Ignarro LJ, Ashley SW, Chaudhuri G
Gastroenterology, Elsevier Bv vol. 108 (4), A1246-A1246.  
01-04-1995
Changes in gastrointestinal smooth muscle reactivity during pregnancy may be induced by nitric oxide
Shah SN, Cuevas JM, Hobbs AJ, Whang E, Ashley SW, Ignarro LJ, Chaudhuri G
Gastroenterology, Elsevier Bv vol. 108 (4), A688-A688.  
01-04-1995
Negative Modulation of Nitric Oxide Synthase by Nitric Oxide and Nitroso Compounds
Griscavage JM, Hobbs AJ, Ignarro LJ
, Elsevier, 215-234.  
01-01-1995
DIFFERENTIAL INHIBITORY EFFECT OF L-NAME ON ENDOTHELIUM-DEPENDENT RELAXATION IN-VITRO AND IN-VIVO
HOBBS AJ, COHEN GA, FITCH RM, YIN TL, CHAUDHURI G, IGNARRO LJ
Faseb Journal vol. 9 (3), A328-A328.  
01-01-1995
THE ROLE OF NITRIC-OXIDE IN MODULATING GASTROINTESTINAL SMOOTH-MUSCLE REACTIVITY DURING PREGNANCY
SHAH SN, CUEVAS JM, HOBBS AJ, WHANG E, ASHLEY SW, IGNARRO LJ, CHAUDHURI G
Faseb Journal vol. 9 (3), A86-A86.  
01-01-1995
CHANGES IN GASTROINTESTINAL SMOOTH-MUSCLE REACTIVITY DURING PREGNANCY MAY BE INDUCED BY NITRIC-OXIDE
SHAKER R, CUEVAS JM, HOBBS AJ, WHANG E, ASHLEY SW, IGNARRO LJ, CHAUDHURI G
Gastroenterology vol. 108 (4), A688-A688.  
01-01-1995
STIMULATED RELEASE OF NITRIC-OXIDE (NO) IS LINKED TO ALPHA-ADRENOCEPTOR ACTIVATION IN-VIVO
COHEN GA, HOBBS AJ, FITCH RM, ASHLEY SW, CRYER MH, CHAUDHURI G, IGNARRO LJ
Faseb Journal vol. 9 (3), A328-A328.  
01-01-1995

1994

Formation of free nitric oxide from l-arginine by nitric oxide synthase: direct enhancement of generation by superoxide dismutase.
Hobbs AJ, Fukuto JM, Ignarro LJ
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 91 (23), 10992-10996.  
08-11-1994
FORMATION OF FREE NITRIC-OXIDE FROM L-ARGININE BY NITRIC-OXIDE SYNTHASE AND ENHANCEMENT OF GENERATION BY SUPEROXIDE-DISMUTASE
HOBBS AJ, GRISCAVAGE JM, ROGERS NE, BYRNS RE, FUKUTO JM, IGNARRO LJ
Faseb Journal vol. 8 (4), A360-A360.  
01-01-1994
FORMATION OF FREE NITRIC OXIDE FROM L-ARGININE BY NITRIC OXIDE SYNTHASE AND ENHANCEMENT OF GENERATION BY SUPEROXIDE DISMUTASE
HOBBS AJ, GRISCAVAGE JM, ROGERS NE, BYRNS RE, FUKUTO JM, IGNARRO LJ
 
01-01-1994

1993

CONVERSION OF NITROXYL (HNO) TO NITRIC-OXIDE (NO) IN BIOLOGICAL-SYSTEMS - THE ROLE OF PHYSIOLOGICAL OXIDANTS AND RELEVANCE TO THE BIOLOGICAL-ACTIVITY OF HNO
FUKUTO JM, HOBBS AJ, IGNARRO LJ
Biochem Bioph Res Co vol. 196 (2), 707-713.  
29-10-1993
The influence of L‐NG‐nitro‐arginine on sympathetic nerve induced contraction and noradrenaline release in the rat isolated anococcygeus muscle
Brave SR, Bhat S, Hobbs AJ, Tucker JF, Gibson A
Journal of Autonomic Pharmacology, Wiley vol. 13 (3), 219-225.  
01-06-1993

1992

An investigation of some S‐nitrosothiols, and of hydroxy‐arginine, on the mouse anococcygeus
Gibson A, Babbedge R, Brave SR, Hart SL, Hobbs AJ, Tucker JF, Wallace P, Moore PK
British Journal of Pharmacology, Wiley vol. 107 (3), 715-721.  
01-11-1992

1991

Differentiation by hydroquinone of relaxations induced by exogenous and endogenous nitrates in non‐vascular smooth muscle: role of superoxide anions
Hobbs AJ, Tucker JF, Gibson A
British Journal of Pharmacology, Wiley vol. 104 (3), 645-650.  
01-11-1991
The influence of L-NG-nitro-arginine on field stimulation induced contractions and acetylcholine release in guinea pig isolated tracheal smooth muscle
Brave SR, Hobbs AJ, Gibson A, Tucker JF
Biochemical and Biophysical Research Communications, Elsevier Bv vol. 179 (2), 1017-1022.  
01-09-1991
Cyclic Nucleotide Content of the Rat Anococcygeus During Relaxations Induced by Drugs or by Non-adrenergic, Non-cholinergic Field Stimulation
Mirzazadeh S, Hobbs AJ, Tucker JF, Gibson A
Journal of Pharmacy and Pharmacology, Oxford University Press (Oup) vol. 43 (4), 247-251.  
01-04-1991

1990

L‐NG‐nitro‐arginine and its methyl ester are potent inhibitors of non‐adrenergic, non‐cholinergic transmission in the rat anococcygeus
Hobbs AJ, Gibson A
British Journal of Pharmacology, Wiley vol. 100 (4), 749-752.  
01-08-1990
l‐NG‐nitro arginine inhibits non‐adrenergic, non‐cholinergic relaxations of guinea‐pig isolated tracheal smooth muscle
Tucker JF, Brave SR, Charalambous L, Hobbs AJ, Gibson A
British Journal of Pharmacology, Wiley vol. 100 (4), 663-664.  
01-08-1990
L-NG-nitroarginine is a potent inhibitor of non-adrenergic, non-cholinergic relaxations in the rat anococcygeus muscle
Gibson A, Hobbs AJ, Mirzazadeh S
European Journal of Pharmacology, Elsevier Bv vol. 183 (5), 1793-1793.  
01-07-1990
l‐NG‐monomethyl arginine andl‐NG‐nitro arginine inhibit non‐adrenergic, non‐cholinergic relaxation of the mouse anococcygeus muscle
Gibson A, Mirzazadeh S, Hobbs AJ, Moore PK
British Journal of Pharmacology, Wiley vol. 99 (3), 602-606.  
01-03-1990

NO-Independent, Haem-Dependent Soluble Guanylate Cyclase Stimulators
Stasch J-P, Hobbs AJ
In Handbook of Experimental Pharmacology, Springer Berlin Heidelberg 277-308.  
Endogenous C-type natriuretic peptide mitigates vascular dysfunction, inflammation and cardiomyopathy during endotoxemia and polymicrobial sepsis
Moyes A, Sand C, Aubdool A, Perez-Ternero C, Mohammad S, Thiemermann C, Hobbs A
cGMP: Generators, Effectors and Therapeutic Implications. 

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconCharacterisation of in vitro & in vivo activity of long-acting CNP mimetic in cardiorenal disease
Adrian Hobbs
£265,680 William Harvey Research Limited
01-05-2025 - 30-04-2027
bullet iconElucidation of the physiological, pathological and pharmacological importance of hydropersulfides
Adrian Hobbs
£25,000 Great Britain Sasakawa Foundation
03-06-2024 - 02-06-2027
bullet iconDefining the roles and therapeutic potential of C-type natriuretic peptide
Adrian Hobbs
£951,763 BHF British Heart Foundation
01-01-2024 - 31-12-2028
bullet iconExploring the use of Antibody-drug conjugates (ADC) for the treatment of Pulmonary Hypertensiona
Adrian Hobbs
£200,713 WHRL William Harvey Research Limited
01-05-2023 - 02-04-2026
bullet iconCharacterization of activity and selectivity of novel natriuretic peptide receptor (NPR)-C agonists
Adrian Hobbs
£145,385 WHRL William Harvey Research Limited
01-11-2021 - 31-10-2026
bullet iconTherapeutic utility of targeting C-type natriuretic peptide to maintain endothelial integrity
Adrian Hobbs and Amrita Ahluwalia
£334,632 Medical Research Council
05-10-2020 - 31-07-2026
bullet iconCommonwealth Studentship
Adrian Hobbs
£44,211 Foreign & Commonwealth Office - GOV UK
01-11-2017 - 31-01-2031

bullet iconDevelopment and validation of a human hypertrophy model for epigenomic investigations
Diego Villar Lozano, Adrian Hobbs and Diego Fernandez Aroca
£75,000 Barts and the London Charity
01-07-2023 - 30-04-2025
bullet iconBBSRC of Identification of novel signalling mechanisms in cardiac cell biology - CASE studentship
Adrian Hobbs
£118,835 Biotechnology and Biological Sciences Research Council
01-10-2021 - 30-09-2025
bullet iconIdentification of novel signalling mechanisms in cardiac cell biology - CASE studentship
Adrian Hobbs
£32,000 AstraZeneca UK Limited
01-10-2021 - 30-09-2025
bullet iconEvaluation of MC1R and NPR-C agonists in fibrotic disease
Adrian Hobbs
£152,022 William Harvey Research Limited
01-10-2020 - 30-09-2025
bullet iconTargeting multidrug resistance proteins to promote cytoprotective cyclic GMP signalling in Heart Failure
Adrian Hobbs
£267,380 BHF British Heart Foundation
01-10-2020 - 30-04-2024
bullet iconEffect of AZ14103514 on cardiac hypertrophy
Adrian Hobbs
£24,573 WHRL William Harvey Research Limited
01-02-2020 - 31-01-2023
bullet iconBritish Pharmacological Society Pickford Award
Adrian Hobbs and Aisah Aubdool
£10,000 BPharmS British Pharmacological Society
17-12-2019 - 16-12-2020
bullet iconLead optimisation of novel small molecule natriuretic peptide receptor (NPR)-C agonists for the treatment of myocardial infarction- BHF extension
Adrian Hobbs
£198,611 BHF British Heart Foundation
01-05-2019 - 31-12-2020
bullet iconEffect of novel natireutic peptide receptor & melanocortin receptor 1 agonists on fibrotic disease
Adrian Hobbs
£152,685 WHRL William Harvey Research Limited
01-04-2019 - 31-03-2022
bullet iconRepurposing Low Dose RGD-mimetics for Improved Heart Failure Treatment
Kairbaan Hodivala-Dilke and Adrian Hobbs
£232,729 BHF British Heart Foundation
01-01-2019 - 31-12-2021
bullet iconDefining a pivotal role for endothelium-derived C-type natriuretic peptide in angiogenesis & vascular remodelling
Adrian Hobbs
£248,430 BHF British Heart Foundation
01-05-2018 - 30-04-2021
bullet iconEffect of PL-5028 on heart failure and lung disease
Adrian Hobbs
£145,942 WHRL William Harvey Research Limited
01-05-2017 - 31-12-2020
bullet iconDelineating physiological and pathological regulatory roles for C-type natriuretic peptide in cardiac structure and function
Adrian Hobbs
£817,911 BHF British Heart Foundation
01-10-2016 - 30-09-2021
bullet iconDelineating physiological and pathological regulatory roles for C-type natriuretic peptide in cardiac structure and function
Adrian Hobbs and Amrita Ahluwalia
£817,911 British Heart Foundation
01-10-2016 - 28-02-2022
bullet iconBlind target X study in combination with bosentan in pulmonary hypertension
Adrian Hobbs
£83,987 WHRL William Harvey Research Limited
01-02-2016 - 30-01-2020