Prof Adina Michael-Titus

Adina Michael-Titus

Professor of Neuroscience

Centre for Neuroscience, Surgery and Trauma, Blizard Institute
Queen Mary University of London
www.qmul.ac.uk/blizard/all-staff/profiles/adina-t-michael-titus.html

Research

brain injury, spinal cord injury, neuroprotection, neuroplasticity

Neuronal Models

Interests

Use of models which explore the response of neuronal and glial cells to various types of injury. Screening in such models of compounds that confer protection.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2025

Membrane transporter progressive ankylosis protein homologue (ANKH/Ank) partially mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation, and ageing
James EN, Teh M-T, Li Y, Wagner-Bock C, Al-Khateeb ZF, Karen-Ng LP, Roberts T, Synchyshyn L et al.
Frontiers in Aging, Frontiers Media Sa vol. 6 
04-06-2025
Modeling Spinal Cord Injury in a Dish with Hyperosmotic Stress: Population-Specific Effects and the Modulatory Role of Mesenchymal Stromal Cell Secretome
Campos J, Palha AT, Fernandes LS, Cibrão JR, Pinho TS, Serra SC, Silva NA, Michael-Titus AT et al.
International Journal of Molecular Sciences, Mdpi vol. 26 (7) 
02-04-2025
A plasma lipid signature in acute human traumatic brain injury: Link with neuronal injury and inflammation markers.
Nessel I, Whiley L, Dyall SC, Michael-Titus AT
J Cereb Blood Flow Metab vol. 45 (3), 443-458.  
01-03-2025

2024

Omega-3 Fatty Acids and Traumatic Injury in the Adult and Immature Brain
Valero-Hernandez E, Tremoleda JL, Michael-Titus AT
Nutrients, Mdpi vol. 16 (23) 
30-11-2024
Lipid Priming of Adipose Mesenchymal Stromal Cells with Docosahexaenoic Acid: Impact on Cell Differentiation, Senescence and the Secretome Neuroregulatory Profile
Campos J, Sampaio-Marques B, Santos D, Barata-Antunes S, Ribeiro M, Serra SC, Pinho TS, Canto-Gomes J et al.
Tissue Engineering and Regenerative Medicine, Springer Nature vol. 22 (1), 113-128.  
04-11-2024
Corrigendum: Raised plasma neurofilament light protein levels are associated with abnormal MRI outcomes in newborns undergoing therapeutic hypothermia
Shah DK, Ponnusamy V, Evanson J, Kapellou O, Ekitzidou G, Gupta N, Clarke P, Michael-Titus AT et al.
Frontiers in Neurology, Frontiers vol. 15 
30-09-2024
The Immune Response in Two Models of Traumatic Injury of the Immature Brain
Al-Khateeb ZF, Henson SM, Tremoleda JL, Michael-Titus AT
Cells, Mdpi vol. 13 (19) 
26-09-2024
Membrane transporter Progressive Ankylosis Protein Homolog (ANKH/Ank) partially mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation and ageing
James EN, Teh M-T, Li Y, Wagner-Bock C, Al-Khateeb ZF, Karen-Ng LP, Roberts T, Synchyshyn L et al.
In Cold Spring Harbor Laboratory 
30-08-2024
Correction: The Omega-3 Fatty Acid Eicosapentaenoic Acid Accelerates Disease Progression in a Model of Amyotrophic Lateral Sclerosis
Yip PK, Pizzasegola C, Gladman S, Biggio ML, Marino M, Jayasinghe M, Ullah F, Dyall SC et al.
Plos One, Public Library of Science (Plos) vol. 19 (7) 
11-07-2024
Incremental induction of NMDAR-STP and NMDAR-LTP in the CA1 area of ventral hippocampal slices relies on graded activation of discrete NMDA receptors
Ingram R, Volianskis R, Georgiou J, Jane DE, Michael-Titus AT, Collingridge GL, Volianskis A
Philosophical Transactions of The Royal Society B Biological Sciences, The Royal Society vol. 379 (1906), 20230239-20230239.  
10-06-2024
The cellular senescence response and neuroinflammation in juvenile mice following controlled cortical impact and repetitive mild traumatic brain injury
Al-Khateeb ZF, Boumenar H, Adebimpe J, Shekerzade S, Henson SM, Tremoleda JL, Michael-Titus AT
Experimental Neurology, Elsevier vol. 374 
05-02-2024

2023

Stroke patients have lower blood levels of nutrients that are relevant for recovery: a systematic review and meta-analysis
Broersen LM, Guida S, Cetinyurek-Yavuz A, van Wijk N, van Helvoort A, Michael-Titus AT, Lansink M
Frontiers in Stroke, Frontiers vol. 2 
13-12-2023
FOR RECOVERY IN STROKE PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Broersen LM, Guida S, Yavuz AC, Lansink M
Clinical Nutrition Espen, Elsevier vol. 58 
01-12-2023
Newborns with Favourable Outcomes after Perinatal Asphyxia Have Upregulated Glucose Metabolism-Related Proteins in Plasma
Yip PK, Bremang M, Pike I, Ponnusamy V, Michael-Titus AT, Shah DK
Biomolecules, Mdpi vol. 13 (10) 
30-09-2023
Long-chain omega-3 polyunsaturated fatty acids are reduced in neonates with substantial brain injury undergoing therapeutic hypothermia after hypoxic–ischemic encephalopathy
Dyall SC, Nessel I, Sharpe JA, Yip PK, Michael-Titus AT, Shah DK
Frontiers in Neurology, Frontiers vol. 14 
30-08-2023
OMEGA-SEC: PRIMING ADIPOSE-TISSUE MESENCHYMAL STEM CELLS SECRETOME WITH DOCOSAHEXAENOIC-ACID FOR REGENERATIVE MEDICINE APPLICATIONS IN THE CENTRAL NERVOUS SYSTEM
Campos JD, Santos DJ, Barata-Antunes S, Serra S, Pinho T, Ribeiro J
 
01-01-2023

2022

C-type natriuretic peptide preserves central neurological function by maintaining blood-brain barrier integrity
Perez Ternero C, Pallier PN, Tremoleda JL, Delogu A, Fernandes C, Michael-Titus AT, Hobbs AJ
Frontiers in Molecular Neuroscience, Frontiers vol. 15, 991112-991112.  
04-10-2022
High phenylalanine concentrations induce demyelination and microglial activation in mouse cerebellar organotypic slices
Thau-Zuchman O, Pallier PN, Savelkoul PJM, Kuipers AAM, Verkuyl JM, Michael-Titus AT
Frontiers in Neuroscience, Frontiers vol. 16 
29-09-2022
Commentary on “Guidelines for the provision of nutrition support therapy in the adult critically ill patient: The American Society for Parenteral and Enteral Nutrition”
Pradelli L, Adolph M, Calder PC, Deutz NE, Michael‐Titus AT
Journal of Parenteral and Enteral Nutrition, Wiley vol. 46 (6), 1226-1227.  
01-07-2022
Deep learning for behaviour classification in a preclinical brain injury model
Teoh L, Ihalage AA, Harp S, Al-Khateeb ZF, Michael-Titus AT, Tremoleda JL, Hao Y
Plos One, Public Library of Science (Plos) vol. 17 (6) 
15-06-2022
Nutritional supplementation reduces lesion size and neuroinflammation in a sex‐dependent manner in a mouse model of perinatal hypoxic‐ischemic brain injury
Brandt MJV, Nijboer CH, Nessel I, Mutshiya TR, Michael‐titus AT, Counotte DS, Schipper L, van der Aa NE et al.
Nutrients vol. 14 (1) 
01-01-2022
Alterations in the Stool Microbiome in Newborns Undergoing Mild Therapeutic Hypothermia after Hypoxic-Ischemic Encephalopathy.
Gala AAD, Kumar H, Sedani S, Openshaw-Lawrence N, Verkuijl JM, Glogowski N, Steingold A, Ponnusamy V et al.
Developmental Neuroscience, Karger Publishers vol. 44 (4-5), 373-383.  
01-01-2022

2021

Umbelliferyloxymethyl phosphonate compounds-weakly binding zinc ionophores with neuroprotective properties
Guesne S, Connole L, Kim S, Motevalli M, Robson L, Michael-Titus AT, Sullivan A
Dalton Transactions vol. 50 (46), 17041-17051.  
14-12-2021
Lipid Profiles from Dried Blood Spots Reveal Lipidomic Signatures of Newborns Undergoing Mild Therapeutic Hypothermia after Hypoxic-Ischemic Encephalopathy
Nixon R, Ip THR, Jenkins B, Yip PK, Clarke P, Ponnusamy V, Michael-Titus AT, Koulman A et al.
Nutrients, Mdpi vol. 13 (12) 
28-11-2021
Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators
France G, Volianskis R, Ingram R, Bannister N, Rothärmel R, Irvine MW, Fang G, Burnell ES et al.
Neuropharmacology, Elsevier vol. 202 
20-10-2021
Neuronal let-7b-5p acts through the Hippo-YAP pathway in neonatal encephalopathy
Ponnusamy V, Ip RTH, Mohamed MAEK, Clarke P, Wozniak E, Mein C, Schwendimann L, Barlas A et al.
Communications Biology, Springer Nature vol. 4 (1) 
30-09-2021
Effect of Obesity on the Expression of Nutrient Receptors and Satiety Hormones in the Human Colon
Baumard L, Weerts ZZRM, Masclee AAM, Keszthelyi D, Michael-Titus AT, Peiris M
Nutrients, Mdpi vol. 13 (4) 
13-04-2021
A new ketogenic formulation improves functional outcome and reduces tissue loss following traumatic brain injury in adult mice
Thau-Zuchman O, Svendsen L, Dyall SC, Paredes-Esquivel U, Rhodes M, Priestley JV, Feichtinger RG, Kofler B et al.
Theranostics, Ivyspring International Publisher vol. 11 (1), 346-360.  
01-01-2021
Effect of obesity on the expression of nutrient receptors and satiety hormones in the human colon
Baumard L, Weerts ZZ, Masclee A, Keszthelyi D, Michael-Titus A, Peiris M
 
01-01-2021

2020

Editorial: Brain Plasticity and Contribution of the Emotional Brain to Neural Remodelling After Injury
Gaviria M, Celeghin A, Michael-Titus AT, Pallier PN
Frontiers in Neurology, Frontiers Media vol. 11, 606271-606271.  
26-10-2020
Raised Plasma Neurofilament Light Protein Levels After Rewarming Are Associated With Adverse Neurodevelopmental Outcomes in Newborns After Therapeutic Hypothermia
Shah DK, Yip PK, Barlas A, Tharmapoopathy P, Ponnusamy V, Michael-Titus AT, Chisholm P
Frontiers in Neurology, Frontiers vol. 11 
23-10-2020
Lipid profiling of brain tissue and blood after traumatic brain injury: A review of human and experimental studies
Nessel I, Michael-Titus AT
Seminars in Cell and Developmental Biology 
07-10-2020
Novel Approaches for Omega-3 Fatty Acid Therapeutics: Chronic Versus Acute Administration to Protect Heart, Brain, and Spinal Cord
Zirpoli H, Chang CL, Carpentier YA, Michael-Titus AT, Ten VS, Deckelbaum RJ
Annual Review of Nutrition, Annual Reviews vol. 40 (1), 161-187.  
23-09-2020
Cover Feature: Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity (Chem. Eur. J. 47/2020)
Vrettos EI, Valverde IE, Mascarin A, Cerofolini L, Fragai M, Parigi G, Hirmiz B, Bekas N et al.
Chemistry - a European Journal, Wiley vol. 26 (47), 10646-10646.  
07-08-2020
Single peptide backbone surrogate mutations to regulate angiotensin GPCR subtype selectivity
Vrettos EI, Valverde IE, Mascarin A, Pallier PN, Cerofolini L, Fragai M, Parigi G, Hirmiz B et al.
Chemistry: a European Journal, Wiley 
21-07-2020
Serotonin expression in the song circuitry of adult male zebra finches.
Yip PK, Schmitzberger M, Al-Hasan M, George J, Tripoliti E, Michael-Titus AT, Clayton D, Priestley JV
Neuroscience 
23-06-2020
Refining rodent models of spinal cord injury
Lilley E, Andrews MR, Bradbury EJ, Elliott H, Hawkins P, Ichiyama RM, Keeley J, Michael-Titus AT et al.
Experimental Neurology, Elsevier vol. 328 
03-03-2020

2019

Studies on long term behavioural changes in group-housed rat models of brain and spinal cord injury using an automated home cage recording system
Yip PK, Chapman GE, Sillito RR, Ip THR, Akhigbe G, Becker SC, Price AW, Michael-Titus AT et al.
Journal of Neuroscience Methods, Elsevier vol. 321, 49-63.  
13-04-2019
Docosahexaenoic acid reduces microglia phagocytic activity via miR-124 and induces neuroprotection in rodent models of spinal cord contusion injury
Yip PK, Bowes AL, Hall JCE, Burguillos MA, Ip THR, Baskerville T, Liu Z-H, Mohamed MAEK et al.
Human Molecular Genetics, Oxford University Press (Oup) vol. 28 (14), 2427-2448.  
11-04-2019
A NEW KETOGENIC FORMULATION IMPROVES FUNCTIONAL OUTCOME AND REDUCES TISSUE DAMAGE FOLLOWING TRAUMATIC BRAIN INJURY
Zuchman OT, Svendsen L, Groenendijk M, de Wilde MC, Tremoleda JL, Michael-Titus AT
 
01-01-2019

2018

Brain phospholipid precursors administered post-injury reduce tissue damage and improve neurological outcome in experimental traumatic brain injury
THAU ZUCHMAN O, Gomes RN, DYALL SC, Davies M, PRIESTLEY JV, Groenendijk M, De Wilde MC, LOPEZ TREMOLEDA J et al.
Journal of Neurotrauma, Mary Ann Liebert vol. 36 (1), 25-42.  
14-12-2018
Commentary on Fish Oil-Containing Lipid Emulsions in Adult Parenteral Nutrition: A Review of the Evidence (https://doi.org/10.1177/0148607117721907).
Adolph M, Calder PC, Deutz NE, Carmona TG, Klek S, Lev S, Mayer K, Michael-Titus AT et al.
Jpen J Parenter Enteral Nutr 
30-03-2018
Raised Plasma Neurofilament Light Protein Levels Are Associated with Abnormal MRI Outcomes in Newborns Undergoing Therapeutic Hypothermia
Shah DK, Ponnusamy V, Evanson J, Kapellou O, Ekitzidou G, Gupta N, Clarke P, Michael-Titus AT et al.
Frontiers in Neurology, Frontiers vol. 9 
05-03-2018
Heart rate sensitive optical coherence angiography
Alvarez K, Lopez-Tremoleda J, Donnan R, Michael-Titus AT, Tomlins PH
Dynamics and Fluctuations in Biomedical Photonics XV. 
13-02-2018

2017

Heart-rate sensitive optical coherence angiography for measuring vascular changes due to posttraumatic brain injury in mice
Lopez-Tremoleda J, Alvarez K, ADEN A, DONNAN RS, MICHAEL-TITUS AT, TOMLINS PH
Journal of Biomedical Optics, Society of Photo-Optical Instrumentation Engineers vol. 22 (12), 121710-121710.  
05-12-2017
Lipids in the intensive care unit: Recommendations from the ESPEN Expert Group
Calder PC, Adolph M, Deutz NE, Grau T, Innes JK, Klek S, Lev S, Mayer K et al.
Clinical Nutrition, Elsevier vol. 37 (1), 1-18.  
07-09-2017
Galectin-3 acts as an early alarmin orchestrating brain immune response and promoting neurodegeneration after traumatic brain injury
Venero JL, Yip PK, Carrillo-Jimenez A, King P, Vilalta A, Nomura K, Chau CC, Tr AMSEZ-HLAJSJL et al.
XIII European Glial Meeting. 
12-07-2017
Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration.
Yip PK, Carrillo-Jimenez A, King P, Vilalta A, Nomura K, Chau CC, Egerton AMS, Liu Z-H et al.
Scientific Reports, Nature Publishing Group vol. 7, 41689-41689.  
27-01-2017
A Single Dose of Docosahexaenoic Acid Increases the Functional Recovery Promoted by Rehabilitation after Cervical Spinal Cord Injury in the Rat.
Liu Z-H, Yip PK, Priestley JV, Michael-Titus AT
J Neurotrauma vol. 34 (9), 1766-1777.  
13-01-2017
Hypoxic-Ischaemic Encephalopathy and the Blood-Brain Barrier in Neonates
Lee WLA, Michael-Titus AT, Shah DK
Developmental Neuroscience, Karger Publishers vol. 39 (1-4), 49-58.  
01-01-2017

2016

In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [18F]GE-180 and effect of docosahexaenoic acid
Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Vadivelu KC, Yip PK, Sosabowski J et al.
European Journal of Nuclear Medicine and Molecular Imaging, Springer Science and Business Media Llc vol. 43 (9), 1710-1722.  
07-05-2016
A specific multi-nutrient intervention, designed to enhance synapse formation and function, improves functional outcome following traumatic brain injury
Thau-Zuchman O, Pallier PN, Davies M, Groenendijk M, de Wilde MC, Tremoleda JL, Michael-Titus AT
Brain Injury vol. 30 (5-6), 679-679.  
01-01-2016

2015

A study of microRNAs from dried blood spots in newborns after perinatal asphyxia: a simple and feasible biosampling method
Ponnusamy V, Kapellou O, Yip E, Evanson J, Wong L-F, Michael-Titus A, Yip PK, Shah DK
Pediatric Research, Springer Nature vol. 79 (5), 799-805.  
31-12-2015
T-14: IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION.
Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Trigg W, Sosabowski J, Mather SJ et al.
Shock vol. 44 Suppl 2, 24-25.  
01-10-2015
A nutrient combination designed to enhance synapse formation and function improves outcome in experimental spinal cord injury
Pallier PN, Poddighe L, Zbarsky V, Kostusiak M, Choudhury R, Hart T, Burguillos MA, Musbahi O et al.
Neurobiology of Disease, Elsevier vol. 82, 504-515.  
24-09-2015
A Single Bolus of Docosahexaenoic Acid Promotes Neuroplastic Changes in the Innervation of Spinal Cord Interneurons and Motor Neurons and Improves Functional Recovery after Spinal Cord Injury
Liu Z-H, Yip PK, Adams L, Davies M, Lee JW, Michael GJ, Priestley JV, Michael-Titus AT
Journal of Neuroscience, Society For Neuroscience vol. 35 (37), 12733-12752.  
16-09-2015
IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION
Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Trigg W, Sosabowski J, Mather SJ et al.
 
01-01-2015

2014

A characterization of white matter pathology following spinal cord compression injury in the rat.
Ward RE, Huang W, Kostusiak M, Pallier PN, Michael-Titus AT, Priestley JV
Neuroscience vol. 260, 227-239.  
28-02-2014
Docosahexaenoic acid attenuates the early inflammatory response following spinal cord injury in mice: in-vivo and in-vitro studies.
Paterniti I, Impellizzeri D, Di Paola R, Esposito E, Gladman S, Yip P, Priestley JV, Michael-Titus AT et al.
J Neuroinflammation vol. 11 
10-01-2014
Omega-3 fatty acids and traumatic neurological injury: from neuroprotection to neuroplasticity?
Michael-Titus AT, Priestley JV
Trends Neurosci vol. 37 (1), 30-38.  
01-01-2014
The Nervous System: Systems of the Body Series, SECOND EDITION
Michael-Titus A, Revest P, Shortland P
 
01-01-2014

2013

Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2.
Nikolakopoulou Z, Nteliopoulos G, Michael-Titus AT, Parkinson EK
Carcinogenesis vol. 34 (12), 2716-2725.  
01-12-2013
The induction of apoptosis in pre-malignant keratinocytes by omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is inhibited by albumin.
Nikolakopoulou Z, Shaikh MH, Dehlawi H, Michael-Titus AT, Parkinson EK
Toxicol Lett vol. 218 (2), 150-158.  
12-04-2013
Transgenic mice with high endogenous omega-3 fatty acids are protected from spinal cord injury.
Lim S-N, Gladman SJ, Dyall SC, Patel U, Virani N, Kang JX, Priestley JV, Michael-Titus AT
Neurobiol Dis vol. 51, 104-112.  
01-03-2013
Improved outcome after spinal cord compression injury in mice treated with docosahexaenoic acid.
Lim S-N, Huang W, Hall JCE, Michael-Titus AT, Priestley JV
Exp Neurol vol. 239, 13-27.  
01-01-2013
The omega-3 fatty acid eicosapentaenoic acid accelerates disease progression in a model of amyotrophic lateral sclerosis.
Yip PK, Pizzasegola C, Gladman S, Biggio ML, Marino M, Jayasinghe M, Ullah F, Dyall SC et al.
Plos One vol. 8 (4) 
01-01-2013
Characterising the effect of substrate stiffness on macrophage behaviour
Perera AP, Kenny F, Connelly J, Michael-Titus A
 
01-01-2013

2012

Docosahexaenoic acid, but not eicosapentaenoic acid, reduces the early inflammatory response following compression spinal cord injury in the rat.
Hall JCE, Priestley JV, Perry VH, Michael-Titus AT
J Neurochem vol. 121 (5), 738-750.  
01-06-2012
Improved outcome after peripheral nerve injury in mice with increased levels of endogenous ω-3 polyunsaturated fatty acids.
Gladman SJ, Huang W, Lim S-N, Dyall SC, Boddy S, Kang JX, Knight MM, Priestley JV et al.
J Neurosci vol. 32 (2), 563-571.  
11-01-2012
Limiting spinal cord injury by pharmacological intervention.
Priestley JV, Michael-Titus AT, Tetzlaff W
Handb Clin Neurol vol. 109, 463-484.  
01-01-2012

2011

Omega-3 fatty acids and acute neurological trauma: a perspective on clinical translation*
Gladman S, Lim S-N, Dyall S, Knight MM, Priestley JV, Michael-Titus AT
OléAgineux Corps Gras Lipides, Edp Sciences vol. 18 (6), 317-323.  
01-11-2011
A multi-nutrient composition with neuroprotective properties in spinal cord injury
Zbarsky-Barquero⁎ V, Sijben J, De Wilde M, Michael-Titus AT
European Journal of Pharmacology, Elsevier vol. 668, e10-e11.  
01-09-2011
Eicosapenaenoic acid (EPA) and docasahexaenoic acid (DHA) reduce IL-1 beta mediated cartilage degradation
Wann AKT, Mistry J, Blain EJ, Michael-Titus A
 
01-06-2011

2010

The effect of mechanical strain or hypoxia on cell death in subpopulations of rat dorsal root ganglion neurons in vitro.
Gladman SJ, Ward RE, Michael-Titus AT, Knight MM, Priestley JV
Neuroscience vol. 171 (2), 577-587.  
01-12-2010
The human G93A-SOD1 mutation in a pre-symptomatic rat model of amyotrophic lateral sclerosis increases the vulnerability to a mild spinal cord compression.
Jokic N, Yip PK, Michael-Titus A, Priestley JV, Malaspina A
Bmc Genomics, Springer vol. 11, 633-633.  
15-11-2010
Docosahexaenoic acid prevents white matter damage after spinal cord injury.
Ward RE, Huang W, Curran OE, Priestley JV, Michael-Titus AT
J Neurotrauma vol. 27 (10), 1769-1780.  
01-10-2010
Activation transcription factor-3 activation and the development of spinal cord degeneration in a rat model of amyotrophic lateral sclerosis.
Malaspina A, Ngoh SFA, Ward RE, Hall JCE, Tai FWD, Yip PK, Jones C, Jokic N et al.
Neuroscience vol. 169 (2), 812-827.  
25-08-2010
Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats.
Dyall SC, Michael GJ, Michael-Titus AT
J Neurosci Res vol. 88 (10), 2091-2102.  
01-08-2010
Omega-3 polyunsaturated fatty acids increase the neurite outgrowth of rat sensory neurones throughout development and in aged animals.
Robson LG, Dyall SC, Sidloff D, Michael-Titus AT
Neurobiol Aging vol. 31 (4), 678-687.  
01-04-2010
Identification of Perineal Sensory Neurons Activated by Innocuous Heat
Kiasalari Z, Salehi I, Zhong Y, McMahon SB
J Comp Neurol vol. 518 (2), 137-162.  
15-01-2010
Eicosapenaenoic acid (EPA) and docasahexaenoic acid (DHA) reduce IL-1β mediated cartilage degradation
Wann AK, Mistry J, Michael-Titus A
 
01-01-2010
6 CRANIAL NERVES AND THE BRAINSTEM
Michael-Titus A, Revest P, Shortland P
In The Nervous System, Elsevier 105-119.  
01-01-2010
7 THE VISUAL SYSTEM
Michael-Titus A, Revest P, Shortland P
In The Nervous System, Elsevier 121-140.  
01-01-2010
8 HEARING AND BALANCE THE AUDITORY AND VESTIBULAR SYSTEMS
Michael-Titus A, Revest P
In The Nervous System, Elsevier 141-158.  
01-01-2010
3 CLINICAL EXAMINATION
Michael-Titus A, Revest P
In The Nervous System, Elsevier 47-58.  
01-01-2010
13 EPILEPSY
Michael-Titus A, Revest P
In The Nervous System, Elsevier 237-250.  
01-01-2010
5 PAIN AND ANALGESIA
Michael-Titus A, Revest P
In The Nervous System, Elsevier 79-104.  
01-01-2010
17 ADDICTION
Michael-Titus A, Revest P
In The Nervous System, Elsevier 301-313.  
01-01-2010
10 MOTOR SYSTEMS II THE BASAL GANGLIA
Michael-Titus A, Shortland P
In The Nervous System, Elsevier 181-197.  
01-01-2010
16 DEPRESSION AND ANXIETY
Michael-Titus A, Shortland P
In The Nervous System, Elsevier 281-300.  
01-01-2010
15 SCHIZOPHRENIA
Michael-Titus A, Revest P
In The Nervous System, Elsevier 267-279.  
01-01-2010
14 DEMENTIA
Michael-Titus A, Revest P
In The Nervous System, Elsevier 251-266.  
01-01-2010
4 THE SPINAL CORD
Michael-Titus A, Revest P, Shortland P
In The Nervous System, Elsevier 59-78.  
01-01-2010
12 INFECTION IN THE CENTRAL NERVOUS SYSTEM
Michael-Titus A, Revest P
In The Nervous System, Elsevier 227-236.  
01-01-2010
1 ORGANIZATION OF THE NERVOUS SYSTEM
Michael-Titus A, Revest P
In The Nervous System, Elsevier 1-30.  
01-01-2010
11 STROKE AND HEAD INJURY
Michael-Titus A, Revest P, Shortland P
In The Nervous System, Elsevier 199-226.  
01-01-2010
9 MOTOR SYSTEMS I DESCENDING PATHWAYS AND CEREBELLUM
Michael-Titus A, Revest P
In The Nervous System, Elsevier 159-180.  
01-01-2010
2 ELEMENTS OF CELLULAR AND MOLECULAR NEUROSCIENCE
Michael-Titus A, Revest P
In The Nervous System, Elsevier 31-46.  
01-01-2010
The acute administration of eicosapentaenoic acid is neuroprotective after spinal cord compression injury in rats.
Lim S-N, Huang W, Hall JCE, Ward RE, Priestley JV, Michael-Titus AT
Prostaglandins Leukot Essent Fatty Acids vol. 83 (4-6), 193-201.  
01-01-2010
Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation.
Wann AKT, Mistry J, Blain EJ, Michael-Titus AT, Knight MM
Arthritis Res Ther vol. 12 (6) 
01-01-2010
The Nervous System: Systems of the Body Series
Michael-Titus A, Revest P, Shortland P
 
01-01-2010

2009

Abstract B152: The selective effect of omega-3 polyunsaturated fatty acids on normal and neoplastic oral keratinocyte apoptosis
Nikolakopoulou Z, Michael-Titus AT
 
10-12-2009
WINTR VISA AWARD WINNER DOES ACUTE TREATMENT WITH DOCOSAHEXAENOIC OR EICOSAPENTAENOIC ACID AFFECT INFLAMMATORY MARKERS FOLLOWING COMPRESSION SPINAL CORD INJURY?
Hall JCE, Priestley JV, Perry VH
 
01-08-2009
Arachidonyl trifluoromethyl ketone is neuroprotective after spinal cord injury.
Huang W, Bhavsar A, Ward RE, Hall JCE, Priestley JV, Michael-Titus AT
J Neurotrauma vol. 26 (8), 1429-1434.  
01-08-2009
Arachidonyl Trifluoromethyl Ketone Is Neuroprotective after Spinal Cord Injury
Huang WL, Bhavsar A, Ward RE, Hall JCE, Michael-Titus AT
J Neurotraum vol. 26 (8), 1429-1434.  
01-08-2009
Omega-3 fatty acids: their neuroprotective and regenerative potential in traumatic neurological injury
Michael-Titus AT
Clin Lipidol vol. 4 (3), 343-353.  
01-06-2009

2008

SONU20176289, a compound combining partial dopamine D(2) receptor agonism with specific serotonin reuptake inhibitor activity, affects neuroplasticity in an animal model for depression.
Michael-Titus AT, Albert M, Michael GJ, Michaelis T, Watanabe T, Frahm J, Pudovkina O, van der Hart MGC et al.
Eur J Pharmacol vol. 598 (1-3), 43-50.  
19-11-2008
The inflammatory response and locomotor recovery following a spinal compression injury
Hall JCE, Michael-Titus A, Perry VH
 
15-07-2008
Is the modulation of retinoid and retinoid-associated signaling a future therapeutic strategy in neurological trauma and neurodegeneration?
Malaspina A
J Neurochem vol. 104 (3), 584-595.  
01-02-2008
Neurological Benefits of Omega-3 Fatty Acids
Dyall SC
Neuromol Med vol. 10 (4), 219-235.  
01-01-2008

2007

Retinoid receptors in chronic degeneration of the spinal cord: observations in a rat model of amyotrophic lateral sclerosis.
Jokic N, Ling YY, Ward RE, Michael-Titus AT, Priestley JV, Malaspina A
J Neurochem vol. 103 (5), 1821-1833.  
01-12-2007
A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury.
Huang WL, King VR, Curran OE, Dyall SC, Ward RE, Lal N, Priestley JV, Michael-Titus AT
Brain vol. 130 (Pt 11), 3004-3019.  
01-11-2007
Erythropoietin and carbamylated erythropoietin are neuroprotective following spinal cord hemisection in the rat.
King VR, Averill SA, Hewazy D, Priestley JV, Torup L, Michael-Titus AT
Eur J Neurosci vol. 26 (1), 90-100.  
01-07-2007
Effect of docosahexaenoic acid on axonal damage after spinal cord injury*
Ward RE, Huang W, Hall JCE
OléAgineux Corps Gras Lipides, Edp Sciences vol. 14 (3-4), 234-234.  
01-05-2007
Effect of docosahexaenoic acid in a mouse facial nerve injury model
Makwana M, Dyall S, Raivich G, Michael-Titus A
OléAgineux Corps Gras Lipides, Edp Sciences vol. 14 (3-4), 233-233.  
01-05-2007
Omega-3 polyunsaturated fatty acids reverse age-related decreases in retinoic acid receptors, retinoid x receptors and peroxisome-proliferator-activated receptors in rat forebrain
Dyall SC, Michael GJ, Michael-Titus AT
OléAgineux Corps Gras Lipides, Edp Sciences vol. 14 (3-4), 232-232.  
01-05-2007
Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain.
Dyall SC, Michael GJ, Whelpton R, Scott AG, Michael-Titus AT
Neurobiol Aging vol. 28 (3), 424-439.  
01-03-2007
Omega-3 fatty acids and neurological injury.
Michael-Titus AT
Prostaglandins Leukot Essent Fatty Acids vol. 77 (5-6), 295-300.  
01-01-2007

2006

Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat.
King VR, Huang WL, Dyall SC, Curran OE, Priestley JV, Michael-Titus AT
J Neurosci vol. 26 (17), 4672-4680.  
26-04-2006
Decrease in parvalbumin-expressing neurons in the hippocampus and increased phencyclidine-induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia
Penschuck S, Flagstad P, Leist M
Eur J Neurosci vol. 23 (1), 279-284.  
01-01-2006

2004

Disruption of neurogenesis on gestational day 17 in the rat causes behavioral changes relevant to positive and negative schizophrenia symptoms and alters amphetamine-induced dopamine release in nucleus accumbens.
Flagstad P, Mørk A, Glenthøj BY, van Beek J, Michael-Titus AT, Didriksen M
Neuropsychopharmacology vol. 29 (11), 2052-2064.  
01-11-2004

2002

Distribution of NMDA and AMPA glutamate receptor subunits in rat prefrontal cortex and the effect of chronic imipramine treatment on the GluR2 subunit
Nazir S, Michael GJ
Brit J Pharmacol vol. 135 
01-03-2002
Effect of noradrenaline and 5-HT on excitatory amino acid release in rat prefrontal cortex
Hawkins A, McCune L
Brit J Pharmacol vol. 135 
01-03-2002
In vivo metabolism and clearance of substance P and co-expressed tachykinins in rat striatum.
Michael-Titus AT, Fernandes K, Setty H, Whelpton R
Neuroscience vol. 110 (2), 277-286.  
01-01-2002
Bioanalysis of temoporfin, a new pharmacodynamic therapy agent
Whelpton R, Michael-Titus AT
 
01-01-2002

2001

Effects of sevoflurane on dopamine, glutamate and aspartate release in an in vitro model of cerebral ischaemia
Toner CC, Connell K, Whelpton R, Bains S, Michael-Titus AT
Brit J Anaesth vol. 86 (4), 550-554.  
01-04-2001

2000

Substance P modulation of striatal dopamine outflow is determined by M1 and M2 muscarinic receptors in male Wistar rats
Khan S, Whelpton R
Neuroscience Letters, Elsevier vol. 293 (3), 179-182.  
01-11-2000
Imipramine and phenelzine decrease glutamate overflow in the prefrontal cortex—a possible mechanism of neuroprotection in major depression?
Michael-Titus AT, Bains S, Jeetle J, Whelpton R
Neuroscience, Elsevier vol. 100 (4), 681-684.  
01-10-2000

1999

N- and C-terminal substance P fragments
Michael-Titus AT, Blackburn D, Connolly Y, Whelpton R
Neuroreport, Wolters Kluwer vol. 10 (10), 2209-2213.  
01-07-1999

1998

Substance P fragments and striatal endogenous dopamine outflow: interaction with substance P
Khan S, Sandhu J, Whelpton R
Neuropeptides, Elsevier vol. 32 (6), 519-526.  
01-12-1998
Identification of substance P metabolites using a combination of reversed-phase high-performance liquid chromatography and capillary electrophoresis
Whelpton R, Michael-Titus AT, Stephens SM, Yau KW
Journal of Chromatography B, Elsevier vol. 716 (1-2), 95-106.  
01-09-1998

1997

Metabolism of substance P in rat striatum studies using a combination of high performance liquid chromatography (HPLC) and capillary electrophoresis (CE)
MichaelTitus AT, Whelpton R
Brit J Pharmacol vol. 122, P79-P79.  
01-10-1997

1996

Substance fragments, SP1-9 and SP6-11, modulate endogenous dopamine outflow in rat striatum
Khan S, Sandhu J, MichaelTitus AT
Brit J Pharmacol vol. 119, P175-P175.  
01-10-1996
N- and C-terminal substance P fragments modulate striatal dopamine outflow through a cholinergic link mediated by muscarinic receptors
Khan S, Grogan E, Whelpton R
Neuroscience, Elsevier vol. 73 (4), 919-927.  
01-08-1996
Distribution and Excretion of Radiolabeled Temoporfin in a Murine Tumor Model
Whelpton R, Michael‐Titus AT, Jamdar RP
Photochemistry and Photobiology, Wiley vol. 63 (6), 885-891.  
01-06-1996
Evidence for modulatory effects of substance P fragments (1–4) and (8–11) on endogenous dopamine outflow in rat striatal slices
Khan S, Whelpton R
Neuroscience Letters, Elsevier vol. 205 (1), 33-36.  
01-02-1996

1995

Binding of temoporfin to the lipoprotein fractions of human serum.
Michael‐Titus A, Whelpton R
British Journal of Clinical Pharmacology, Wiley vol. 40 (6), 594-597.  
01-12-1995
SUBSTANCE-P AND ITS FRAGMENT-(1-7) AND FRAGMENT-(5-11) MODULATE STRIATAL DOPAMINE OUTFLOW VIA A CHOLINERGIC LINK MEDIATED BY MUSCARINIC RECEPTORS
KHAN S, GROGAN E
Brit J Pharmacol vol. 116, P96-P96.  
01-10-1995
Substance P-(1–7) and substance P-(5–11) locally modulate dopamine release in rat striatum
Khan S, Brooks N, Whelpton R
European Journal of Pharmacology, Elsevier vol. 282 (1-3), 229-233.  
01-08-1995
ENDOGENOUS DOPAMINE OUTFLOW FROM RAT STRIATAL SLICES IN STATIC AND DYNAMIC CONDITIONS
KHAN S, WHELPTON R
Neurosci Res Commun vol. 16 (3), 145-153.  
01-05-1995
DISTRIBUTION OF TEMOPORFIN, A NEW PHOTOSENSITIZER FOR THE PHOTODYNAMIC THERAPY OF CANCER, IN A MURINE TUMOR MODEL
Whelpton R, Michael‐Titus AT, Basra SS
Photochemistry and Photobiology, Wiley vol. 61 (4), 397-401.  
01-04-1995
TEMOPORFIN BINDING TO HUMAN SERUM-LIPOPROTEINS
WHELPTON R, MICHAELTITUS AT
Brit J Pharmacol vol. 114, P265-P265.  
01-04-1995
EFFECTS OF 6-HYDROXYDOPAMINE LESIONS IN THE VENTRAL TEGMENTAL AREA OR SUBSTANTIA-NIGRA ON DOPAMINE RELEASE IN SUBREGIONS OF THE RAT STRIATUM
IRAVANI MM, MICHAELTITUS A, WHELPTON R
Brit J Pharmacol vol. 114, P337-P337.  
01-04-1995

1994

Comparative study of the effects of mu, delta and kappa opioid agonists on 3H-dopamine uptake in rat striatum and nucleus accumbens
Das D, Rogers J, Michael-Titus AT
Neuropharmacology, Elsevier vol. 33 (2), 221-226.  
01-02-1994

1992

Differential Effect of Intrastriatal Kainic Acid on the Modulation of Dopamine Release by μ‐ and δ‐Opioid Peptides: A Microdialysis Study
Dourmap N, Michael‐Titus A
Journal of Neurochemistry, Wiley vol. 58 (2), 709-713.  
01-02-1992

1991

Desensitization of μ-opioid receptors does not modify the analgesia induced by an enkephalinase inhibitor
Bousselmame R, Costentin J
European Journal of Pharmacology, Elsevier vol. 203 (2), 295-297.  
01-10-1991
Chronic inhibition of enkephalinase induces changes in the antinociceptive and locomotor effects of the enkephalinase inhibitor acetorphan in rats
Bousselmame R, Eustache M, Costentin J
Neuropharmacology, Elsevier vol. 30 (8), 865-870.  
01-08-1991

1990

Stimulation of dopamine D2 receptors induces an analgesia involving an opiodergic but non enkephalinergic link
Michael-Titus A, Bousselmame R
European Journal of Pharmacology, Elsevier vol. 187 (2), 201-207.  
01-10-1990
Acetorphan, an Enkephalinase Inhibitor, Modulates Dopaminergic Transmission in Rat Olfactory Tubercle, but not in the Nucleus Accumbens and Striatum
Dourmap N, Michael‐Titus A
European Journal of Neuroscience, Wiley vol. 2 (9), 783-787.  
01-09-1990
Local enkephalins tonically modulate dopamine release in the striatum: a microdialysi study
Dourmap N, Costentin J
Brain Research, Elsevier vol. 524 (1), 153-155.  
01-07-1990
Role of delta opioid receptors in the effects of inhibitors of enkephalin-degrading peptidases on the horizontal and vertical components of locomotion in mice
Michael-Titus A, Dourmap N, Schwartz JC
Neuropeptides, Elsevier vol. 15 (2), 89-100.  
01-02-1990
Dopamine D1 and D2 receptors mediate opposite effects of apomorphine on the body temperature of reserpinized mice
Costentin J, Duterte-Boucher D, Panissaud C
Neuropharmacology, Elsevier vol. 29 (1), 31-35.  
01-01-1990

1989

MU and delta opioid receptors control differently the horizontal and vertical components of locomotor activity in mice
Michael-Titus A, Dourmap N
Neuropeptides, Elsevier vol. 13 (4), 235-242.  
01-05-1989
Stimulation of central D1 dopamine receptors reverses reserpine-induced hypothermia in mice
Duterte-Eoucher D, Panissaud C, Michael-Titus A
Neuropharmacology, Elsevier vol. 28 (4), 419-421.  
01-04-1989
Role of endogenous enkephalins in locomotion and nociception studied with peptidase inhibitors in two inbred strains of mice (C57BL/6J AND DBA/2J)
Michael-Titus A, Caline H, Schwartz J-C
Neuropharmacology, Elsevier vol. 28 (2), 117-122.  
01-02-1989

1987

Analgesic effects of metapramine and evidence against the involvement of endogenous enkephalins in the analgesia induced by tricyclic antidepressants
MichaelTitus A, Costentin J
Pain, Wolters Kluwer vol. 31 (3), 391-400.  
01-12-1987
Role of endogenous enkephalins in locomotion evidenced by acetorphan, an enkephalinase inhibitor.
Michael-Titus A, Preterre P, Giros B
Journal of Pharmacology and Experimental Therapeutics, Elsevier vol. 243 (3), 1062-1066.  
01-12-1987

A single injection of docosahexaenoic acid induces a pro-resolving lipid mediator profile in the injured tissue and a long-lasting reduction in neurological deficit after traumatic brain injury in mice
Thau Zuchman O, Ingram R, HARVEY GG, Cooke T, Palmas F, Pallier PN, Brook J, Priestley JV et al.
Journal of Neurotrauma, Mary Ann Liebert 
Novel mechanism of action for neuronal let-7b-5p in neonatal encephalopathy through the Hippo pathway
Ponnusamy V, Ip R, Mohamed M, Clarke P, Wozniak E, Mein C, Schwendimann L, Barlas A et al.
In Research Square 

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconAlternative Substrates in the Critically Ill Subjects with Traumatic Brain Injury (ASICS-TBI) trial (QMUL Costings)
Zudin Puthucheary, John Prowle, Adina Michael-Titus and Christopher Uff
£471,370 Barts and the London Charity
01-08-2025 - 31-07-2027
bullet iconCognitive function in HIV-exposed uninfected children in rural Zimbabwe
Andrew Prendergast, Melanie Smuk, Michael Pluess, Simon McArthur and Adina Michael-Titus
£363,260 MRC Medical Research Council
01-11-2023 - 31-10-2026

solid heart iconA stem cell research approach to elucidate the molecular mechanisms underlying heterogeneity of outcome in traumatic brain injury
Agnes Nishimura, Adina Michael-Titus and Christopher Uff
£74,845 Barts and the London Charity
04-09-2023 - 03-09-2025
bullet iconAdditional Support BBSRC iCASE studentship
Adina Michael-Titus
£52,000 Nutricia Research BV
19-09-2022 - 18-09-2025
bullet iconLPC-N3 for neuroprotection in TBI
Adina Michael-Titus
£110,432 AKER BIOMARINE Antarctic AS
01-01-2021 - 30-09-2022
bullet iconDevelopment of nutritional application in the neuro science area
Adina Michael-Titus
£1,035,505 Nutricia Research BV
01-10-2020 - 30-09-2025
bullet iconCombinatorial treatment for rehabilitation after brain and spinal cord injury
Adina Michael-Titus
£86,490 Bernice Hazle Charitable Trust, The
01-10-2018 - 31-12-2024