Dr Abish Stephen
Lecturer
Institute of Dentistry
Queen Mary University of London
Queen Mary University of London
Research
Bioreactors, Volatile Organic Compounds, Oral Microbiome, Co-culture, Microbial Ecology, Disease Biomarkers
Interests
Dr. Abish Stephen is an expert in developing microcosm bioreactors tailored for volatile metabolomics, providing insights into microbial metabolic interactions. His research focuses on elucidating the oral microbiome’s influence on local and systemic diseases, using advanced co-culture models to study ecological interactions between bacteria and fungi. By integrating genomic, transcriptomic, and metabolomic analyses of these models, Dr. Stephen is pioneering approaches to identify biomarkers for the early detection of cancer. His work bridges microbiology, bioinformatics, and systems biology, advancing understanding of the human microbiome’s role in health and disease.Publications
Publications of specific relevance to Predictive <em>in vitro</em> Models2024
The antimicrobial effect of different vitamin D compounds on Streptococcus mutans and their impact on glycosyltransferase expressionPicolo M, Stephen A and Baysan A
Journal of Oral Microbiology, Taylor & Francis vol. 16 (1)
27-03-2024
2023
Associations between Host Genetic Variants and Subgingival Microbiota in Patients with the Metabolic SyndromeNibali L, Stephen AS, Allaker RP, Di Pino A, Terranova V, Pisano M, Di Marca S, Ferrara V, Scicali R, Purrello F, Donos N, Regolo M and Malatino L
International Journal of Molecular Sciences, Mdpi vol. 24 (23)
23-11-2023
O06 Exploring host–microbiome–immune interactions using singular and multispecies inoculations in optimized 3D skin modelsMcPolin-Hall E, Stephen A, Pardieu C, Allaker R, Philpott M, Bhogal R, Pople J and Hannen R
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e6-e6.
07-07-2023
Engineering Biofouling Resistant Materials Through the Systematic Adaptation of Surface MorphologySadler E, Stephen AS, Allaker RP and Crick CR
Advanced Materials Interfaces vol. 10 (12)
24-04-2023
2022
In vitro effectiveness of pomegranate extract present in pet oral hygiene products against canine oral bacterial speciesStephen AS, Nicolas CS, Lloret F and Allaker RP
Veterinary World, Veterinary World vol. 15 (7), 1714-1718.
01-07-2022
Analysis of gingival crevicular fluid biomarkers in patients with metabolic syndromeNibali L, Stephen A, Hagi-Pavli E, Allaker R, Pino AD, Terranova V, Pisano M, Marca SD, Ferrara V, Scicali R, Giordano M, Purrello F, Donos N and Malatino L
Journal of Dentistry, Elsevier vol. 118
06-02-2022
2021
Interdental and subgingival microbiota may affect the tongue microbial ecology and oral malodour in health, gingivitis and periodontitisStephen AS, Dhadwal N, Nagala V, Gonzales‐Marin C, Gillam DG, Bradshaw DJ, Burnett GR and Allaker RP
Journal of Periodontal Research, Wiley vol. 56 (6), 1174-1184.
06-09-2021
The Extracellular Metabolome Stratifies Low and High Risk Potentially Premalignant Oral Keratinocytes and Identifies Citrate as a Potential Non-Invasive Marker of Tumour ProgressionKaren-Ng LP, James EL, Stephen A, Bennett MH, Mycielska ME and Parkinson EK
Cancers, Mdpi vol. 13 (16)
21-08-2021
The Relationship between both Partial and Complete Denture Wearers and the Presence of Oral Malodour and the Effect of Denture Cleansers on the Oral MicrobiotaGillam DG, PLASTARGIAS I, Stephen A, AL-MUTAIRI R and Allaker RP
Advances in Dentistry & Oral Health vol. 13 (5)
26-01-2021
2018
Development of a 3D Collagen Model for the In Vitro Evaluation of Magnetic-assisted OsteogenesisYuan Z, Memarzadeh K, Stephen AS, Allaker RP, Brown RA and Huang J
Scientific Reports, Springer Nature vol. 8 (1)
02-11-2018
Activity of a nitric oxide-generating wound treatment system against wound pathogen biofilmsWaite RD, Stewart JE, Stephen AS and Allaker RP
International Journal of Antimicrobial Agents, Elsevier vol. 52 (3), 338-343.
14-04-2018
2017
Use of Probiotics and Oral Health.Allaker RP and Stephen AS
Curr Oral Health Rep, Springerlink vol. 4 (4), 309-318.
19-10-2017
The role of periodontal niches in influencing the tongue microbiota: relationship with periodontitis and oral malodourStephen AS, Gonzalez-Marin C, Gillam DG, Burnett GR, Bradshaw DJ and Allaker RP
Journal of Oral Microbiology vol. 9 (sup1), 1325201-1325201.
31-05-2017
2016
In Vitro Effect of Porphyromonas gingivalis Methionine Gamma Lyase on Biofilm Composition and Oral Inflammatory Response.Stephen AS, Millhouse E, Sherry L, Aduse-Opoku J, Culshaw S, Ramage G, Bradshaw DJ, Burnett GR and Allaker RP
Plos One, Public Library of Science (Plos) vol. 11 (12), e0169157-e0169157.
29-12-2016
The relationship between Oral Malodour and Chronic Periodontitis: Role of Volatile Sulfur CompoundsSTEPHEN AS
18-07-2016
2014
In vitro growth characteristics and volatile sulfur compound production of Solobacterium mooreiStephen AS, Naughton DP, Pizzey RL, Bradshaw DJ and Burnett GR
Anaerobe, Elsevier vol. 26, 53-57.
31-01-2014
2011
In vitro effects of novel toothpaste actives on components of oral malodourBurnett GR, Stephen AS, Pizzey RL and Bradshaw DJ
International Dental Journal, Elsevier vol. 61 (Suppl 3), 67-73.
18-07-2011
Grants
Grants of specific relevance to Predictive in vitro ModelsMechanisms underlying preterm birth in women with HIV in rural ZimbabweAndrew Prendergast, Ruairi Robertson, Melanie Smuk, Claire Bourke, Nikolaos Donos, Robert Allaker, Abish Stephen, Conrad Bessant, Stefaan Verbruggen and Tina Chowdhury
£1,142,315 MRC Medical Research Council
01-05-2024 - 30-04-2027
Metatranscriptomics of oral biofilms to identify functional pathways in oral malodourAbish Stephen
£38,586
01-06-2023 - 30-04-2025
Development of host-microbial models of aerodigestive squamous cancers for early diagnosticsAbish Stephen
£1,060 CR-UK Cancer Research UK
01-09-2023 - 31-01-2025
New Experiments to support fresh breath & gum health claims for MeerkatAbish Stephen
£12,276 GSK GlaxoSmithKline UK Ltd
01-11-2020 - 31-01-2021