Prediction of Atrial and Ventricular Arrhythmias using Multiple Cardiovascular Risk Factor Polygenic Risk Scores
Ramírez J, van Duijvenboden S, Orini M, Lambiase PD, Tinker A, Young WJ and Munroe PB
Heart Rhythm, Elsevier 
01-12-2024

The genetic architecture of exercise-induced ventricular ectopy
Van Duijvenboden S, Nicholson G, Smith-Byrne K, Portas L, Atkins J, Ramirez J, Orini M, Young WJ, Tinker A, Lambiase PD, Munroe PB and Doherty A
European Heart Journal, Oxford University Press (Oup) vol. 45 (Supplement_1) 
28-10-2024

Circulating metabolites associate with the QT interval in individuals without prevalent cardiovascular disease
Young W, Sanghvi MM, Ramirez J, Orini M, Tinker A, Warren HR, Lambiase PD and Munroe PB
European Heart Journal, Oxford University Press (Oup) vol. 45 (Supplement_1) 
28-10-2024

Long-term time-to-ventricular arrhythmic event prediction using a deep learning based model on the electrocardiogram signal
Ramirez J, Martinez JP, Van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB and Miguel A
European Heart Journal, Oxford University Press (Oup) vol. 45 (Supplement_1) 
28-10-2024

Genome‐Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants
Young WJ, van der Most PJ, Bartz TM, Bos MM, Biino G, Duong T, Foco L, Lominchar JT, Müller‐Nurasyid M, Nardone GG, Pecori A, Ramirez J, Repetto L, Schramm K, Shen X, van Duijvenboden S, van Heemst D, Weiss S, Yao J, Benjamins J, Alonso A, Spedicati B, Biggs ML, Brody JA, Dörr M, Fuchsberger C, Gögele M, Guo X, Ikram MA and Jukema JW
Journal of The American Heart Association, Wolters Kluwer vol. 13 (17) 
29-08-2024

Tissue-resident memory T cells in epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in atrial fibrillation
Vyas V, Sandhar B, Keane JM, Wood EG, Blythe H, Jones A, Shahaj E, Fanti S, Williams J, Metic N, Efremova M, Ng HL, Nageswaran G, Byrne S, Feldhahn N, Marelli-Berg F, Chain B, Tinker A, Finlay MC and Longhi MP
Nature Cardiovascular Research, Springer Nature vol. 3 (9), 1067-1082.  
23-08-2024

Fine mapping of candidate effector genes for heart rate
Ramírez J, van Duijvenboden S, Young WJ, Chen Y, Usman T, Orini M, Lambiase PD, Tinker A, Bell CG, Morris AP and Munroe PB
Human Genetics, Springer Nature vol. 143 (9-10), 1207-1221.  
06-07-2024

The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart
Tsisanova E, Nobles M, Sebastian S, Ng K-E, Thomas A, Weinstein LS, Munroe PB and Tinker A
Journal of Biological Chemistry, Elsevier vol. 300 (7) 
13-06-2024

Identification and characterisation of functional Kir6.1‐containing ATP‐sensitive potassium channels in the cardiac ventricular sarcolemmal membrane
Brennan S, Chen S, Makwana S, Esposito S, McGuinness LR, Alnaimi AIM, Sims MW, Patel M, Aziz Q, Ojake L, Roberts JA, Sharma P, Lodwick D, Tinker A, Barrett‐Jolley R, Dart C and Rainbow RD
British Journal of Pharmacology, Wiley vol. 181 (18), 3380-3400.  
19-05-2024

Transcriptional response of the heart to vagus nerve stimulation.
Kellett DO, Aziz Q, Humphries JD, Korsak A, Braga A, Del Arroyo AG, Crescente M, Tinker A, Ackland GL and Gourine AV
Physiol Genomics vol. 56 (2), 167-178.  
01-02-2024

Transcriptional response of the heart to vagus nerve stimulation.
Kellett DO, Aziz Q, Humphries JD, Korsak A, Braga A, Gutierrez Del Arroyo A, Crescente M, Tinker A, Ackland GL and Gourine AV
Physiol Genomics 
04-12-2023

Combining hypothesis-driven ECG indices with machine learning improves ventricular arrhythmic risk prediction in a low-risk population
Ramirez J, Martinez JP, Van Duijvenboden S, Tinker A, Lambiase P, Orini M, Munroe PB and Miguel A
European Heart Journal, Oxford University Press (Oup) vol. 44 (Supplement_2) 
09-11-2023

Ultra-short heart rate variability over 15 seconds is associated with increased long-term risk of cardiovascular disease
Orini M, Van Duijvenboden S, Young WJ, Ramirez J, Jones AR, Tinker A, Munroe PB and Lambiase PD
European Heart Journal, Oxford University Press (Oup) vol. 44 (Supplement_2) 
09-11-2023

Long-term association of ultra-short heart rate variability with cardiovascular events
Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Hughes AD, Tinker A, Munroe PB and Lambiase PD
Scientific Reports, Springer Nature vol. 13 (1) 
03-11-2023

Hindering the progression of cardiac fibrosis in acromegaly - the role of somatostatin receptor ligands
Sanpawithayakul K, Mistry A, Rai A, Funge G, Sebastian S, Solomou A, Lillina VM, Gaston-Massuet C, Tinker A, Begalli F and Korbonits M
Endocrine Abstracts, Bioscientifica 
31-10-2023

GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway
Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P, Miller D, Harmer S, Poliandri A, Kogaki S, Sakata Y, Dunkel L, Tinker A, Hadjantonakis A-K, Sawa Y, Sasaki H, Ozono K, Suzuki K and Yashiro K
Cell Reports, Elsevier vol. 42 (11) 
25-10-2023

Prognostic Significance of Different Ventricular Ectopic Burdens During Submaximal Exercise in Asymptomatic UK Biobank Subjects
van Duijvenboden S, Ramírez J, Orini M, Aung N, Petersen SE, Doherty A, Tinker A, Munroe PB and Lambiase PD
Circulation, Wolters Kluwer vol. 148 (24), 1932-1944.  
19-10-2023

Hypoxia Promotes Atrial Tachyarrhythmias via Opening of ATP-Sensitive Potassium Channels
Specterman MJ, Aziz Q, Li Y, Anderson NA, Ojake L, Ng K-E, Thomas AM, Finlay MC, Schilling RJ, Lambiase PD and Tinker A
Circulation Arrhythmia and Electrophysiology, Wolters Kluwer vol. 16 (9) 
30-08-2023

Abstract P2043: Loss Of Full-length Mylk3 Causes Dilated Cardiomyopathy Via A Myl2-independent Mechanism
Williams JL, Smith CJ, Mastroianni G, Stewart M, Cutillas P, Tinker A and Metherell L
Circulation Research, Wolters Kluwer vol. 133 (Suppl_1) 
04-08-2023

Immediate and sustained increases in the activity of vagal preganglionic neurons during exercise and after exercise training
Korsak A, Kellett DO, Aziz Q, Anderson C, D’Souza A, Tinker A, Ackland GL and Gourine AV
Cardiovascular Research, Oxford University Press (Oup) vol. 119 (13), 2329-2341.  
30-07-2023

Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools
Zawada D, Kornherr J, Meier AB, Santamaria G, Dorn T, Nowak-Imialek M, Ortmann D, Zhang F, Lachmann M, Dreßen M, Ortiz M, Mascetti VL, Harmer SC, Nobles M, Tinker A, De Angelis MT, Pedersen RA, Grote P, Laugwitz K-L, Moretti A and Goedel A
Nature Communications, Springer Nature vol. 14 (1) 
03-04-2023

Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
Young WJ, Haessler J, Benjamins J-W, Repetto L, Yao J, Isaacs A, Harper AR, Ramirez J, Garnier S, van Duijvenboden S, Baldassari AR, Concas MP, Duong T, Foco L, Isaksen JL, Mei H, Noordam R, Nursyifa C, Richmond A, Santolalla ML, Sitlani CM, Soroush N, Thériault S, Trompet S, Aeschbacher S, Ahmadizar F, Alonso A, Brody JA, Campbell A and Correa A
Nature Communications, Springer Nature vol. 14 (1) 
14-03-2023

Premature atrial and ventricular contractions detected on wearable-format electrocardiograms and prediction of cardiovascular events
Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Tinker A, Munroe PB and Lambiase PD
European Heart Journal - Digital Health, Oxford University Press (Oup) vol. 4 (2), 112-118.  
03-02-2023

Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels
Bercea C, Limbu R, Behnam K, Ng K-E, Aziz Q, Tinker A, Tamagnini F, Cottrell GS and McNeish AJ
Frontiers in Physiology, Frontiers vol. 13 
15-12-2022

Role of cardiac mitofusins in cardiac conduction following simulated ischemia–reperfusion
Kwek X-Y, Hall AR, Lim W-W, Katwadi K, Soong PL, Grishina E, Lin K-H, Crespo-Avilan G, Yap EP, Ismail NI, Chinda K, Chung YY, Wei H, Shim W, Montaigne D, Tinker A, Ong S-B and Hausenloy DJ
Scientific Reports, Springer Nature vol. 12 (1) 
06-12-2022

Investigating cardiomyocyte dysfunction in dilated cardiomyopathy associated with Duchenne muscular dystrophy
Wilson D, Tinker A and Iskratsch T
Journal of Molecular and Cellular Cardiology, Elsevier vol. 173 
01-12-2022

Slowing Heart Rate Protects Against Pathological Cardiac Hypertrophy
Sebastian S, Weinstein LS, Ludwig A, Munroe P and Tinker A
Function, Oxford University Press (Oup) vol. 4 (1) 
01-11-2022

The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction
Iskratsch T, Wilson D and Tinker A
Communications Biology, Nature Research 
27-09-2022

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
Young WJ, Lahrouchi N, Isaacs A, Duong T, Foco L, Ahmed F, Brody JA, Salman R, Noordam R, Benjamins J-W, Haessler J, Lyytikäinen L-P, Repetto L, Concas MP, van den Berg ME, Weiss S, Baldassari AR, Bartz TM, Cook JP, Evans DS, Freudling R, Hines O, Isaksen JL, Lin H, Mei H, Moscati A, Müller-Nurasyid M, Nursyifa C, Qian Y and Richmond A
Nature Communications, Springer Nature vol. 13 (1) 
01-09-2022

ECG T‐Wave Morphologic Variations Predict Ventricular Arrhythmic Risk in Low‐ and Moderate‐Risk Populations
Ramírez J, Kiviniemi A, van Duijvenboden S, Tinker A, Lambiase PD, Junttila J, Perkiömäki JS, Huikuri HV, Orini M and Munroe PB
Journal of The American Heart Association, Wolters Kluwer vol. 11 (17) 
29-08-2022

Abstract P2005: Loss Of Full-length Mylk3 Causes Dilated Cardiomyopathy Via A MYL2-independent Mechanism
Williams JL, Paudyal A, Stewart M, Cutillas P, Tinker A and Metherell L
Circulation Research, Wolters Kluwer vol. 131 (Suppl_1), ap2005-ap2005.  
05-08-2022

Prediction of coronary artery disease and major adverse cardiovascular events using clinical and genetic risk scores for cardiovascular risk factors
Ramírez J, Van Duijvenboden S, Young W, Tinker A, Lambiase P, Orini M and Munroe P
Atherosclerosis, Elsevier vol. 355, 3-4.  
01-08-2022

Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors
Ramírez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M and Munroe PB
Circulation Genomic and Precision Medicine vol. 15 (5), e003441-e003441.  
13-07-2022

Smooth muscle ATP-sensitive potassium channels mediate migraine-relevant hypersensitivity in mouse models
Christensen SL, Rasmussen RH, La Cour S, Ernstsen C, Hansen TF, Kogelman LJ, Lauritzen SP, Guzaite G, Styrishave B, Janfelt C, Christensen ST, Aziz Q, Tinker A, Jansen-Olesen I, Olesen J and Kristensen DM
Cephalalgia, Sage Publications vol. 42 (2), 93-107.  
24-11-2021

Abstract 14037: A Shorter Myosin Light Chain Kinase 3 Isoform Maintains Myosin Light Chain 2 Phosphorylation but Does Not Attenuate the Dilated Cardiomyopathy Seen in C57BL/6N Mice
Williams J, paudyal A, Stewart M, Cutillas P, Cox RD, Tinker A and Metherell L
Circulation, Wolters Kluwer vol. 144 (Suppl_1), a14037-a14037.  
16-11-2021

Does knowledge of the mutation in hereditary long QT syndrome aid risk stratification?
Tinker A
European Heart Journal, Oxford University Press (Oup) vol. 42 (46), 4756-4758.  
20-09-2021

B-PO02-015 ENHANCING MUTANT I KSCHANNEL ACTIVITY BY ALTERING ENDOGENOUS PIP2 LEVELS AND ITS INTERACTION WITH PKA SIGNALLING PATHWAY
Rathod VSHS, Harmer S, Royal A, Aziz Q, Lambiase P and Tinker A
Heart Rhythm, Elsevier vol. 18 (8) 
01-08-2021

Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders
van Duijvenboden S, Ramírez J, Young WJ, Orini M, Mifsud B, Tinker A, Lambiase PD and Munroe PB
Human Molecular Genetics, Oxford University Press (Oup) vol. 30 (24), 2513-2523.  
19-07-2021

Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathy
Ng KE, Delaney PJ, Thenet D, Murtough S, Webb CM, Zaman N, Tsisanova E, Mastroianni G, Walker SLM, Westaby JD, Pennington DJ, Pink R, Kelsell DP and Tinker A
Cell and Tissue Research, Springer Nature vol. 386 (1), 79-98.  
08-07-2021

Enhancing mutant IKS channel activity by increasing endogenous PIP2 levels and its interaction with PKA signalling pathway
Rathod V, Harmer S, Royal A, Aziz Q, Lambiase P and Tinker A
Ep Europace, Oxford University Press (Oup) vol. 23 (Supplement_3) 
24-05-2021

Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization
Young WJ, Warren HR, Mook-Kanamori DO, Ramírez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D, Lambiase PD, Jukema JW, Munroe PB and Noordam R
Circulation Genomic and Precision Medicine, Wolters Kluwer vol. 14 (3) 
22-04-2021

The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate
Sebastian S, Nobles M, Tsisanova E, Ludwig A, Munroe PB and Tinker A
Physiological Genomics, American Physiological Society vol. 53 (4), 150-159.  
15-03-2021

No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis
Mensah-Kane J, Schmidt AF, Hingorani AD, Finan C, Chen Y, van Duijvenboden S, Orini M, Lambiase PD, Tinker A, Marouli E, Munroe PB and Ramírez J
Frontiers in Genetics, Frontiers vol. 12 
18-02-2021

Analysing electrocardiographic traits and predicting cardiac risk in UK biobank
Ramírez J, van Duijvenboden S, Young WJ, Orini M, Jones AR, Lambiase PD, Munroe PB and Tinker A
Jrsm Cardiovascular Disease, Sage Publications vol. 10 
01-01-2021

The Pharmacology of ATP-Sensitive K+ Channels (KATP)
Li Y, Aziz Q and Tinker A
Handbook of Experimental Pharmacology, Springer Nature vol. 267, 357-378.  
01-01-2021

ATP-Dependent K+ Channels
Tinker A, Aziz Q and Li Y
In Encyclopedia of Molecular Pharmacology, Springer Nature 261-269.  
01-01-2021

Ventricular Restitution Predicts Paroxysmal Atrial Fibrillation in Horses
Ramírez J and Tinker A
Function, Oxford University Press (Oup) vol. 2 (1) 
09-11-2020

A Method to Minimise the Impact of ECG Marker Inaccuracies on the Spatial QRS-T angle: Evaluation on 1,512 Manually Annotated ECGs
Young WJ, van Duijvenboden S, Ramírez J, Jones A, Tinker A, Munroe PB, Lambiase PD and Orini M
Biomedical Signal Processing and Control, Elsevier vol. 64 
05-11-2020

Cardiac phenotype in ATP1A3-related syndromes: A multicentre cohort study.
Balestrini S, Mikati MA, Garcia-Roves RA, Carboni M, Hunanyan AS, Kherallah B, McLean M, Prange L, De Grandis E, Gagliardi A, Pisciotta L, Stagnaro M, Veneselli E, Campistol J, Fons C, Pias-Peleteiro L, Brashear A, Miller C, Samoes R, Brankovic V, Padiath QS, Potic A, Pilch J, Vezyroglou K, Bye AME, Davis AM, Ryan MM, Semsarian C, Hollingsworth G and Scheffer IE
Neurology, American Academy of Neurology 
10-09-2020

Endothelial ATP-Sensitive Potassium Channel Protects Against the Development of Hypertension and Atherosclerosis.
Li Y, Aziz Q, Anderson N, Ojake L and Tinker A
Hypertension, American Heart Association, HYPERTENSIO-HYPERTENSIO.  
13-07-2020

Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia
Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S, Hobbs AJ, Thiemermann C and Tinker A
Journal of Molecular Medicine, Springer Science and Business Media Llc 
06-07-2020

The contribution of non-coding regulatory elements to cardiovascular disease
Villar D, Frost S, Deloukas P and Tinker A
Open Biology, The Royal Society vol. 10 (7), 200088-200088.  
01-07-2020

The Pathophysiology of Cardiac Abnormalities in Cantu Syndrome: Perspective on The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome.
Aziz Q and Tinker A
Function, Oup vol. 1 (1), zqaa005-zqaa005.  
23-06-2020

Genetic Basis and Prognostic Value of Exercise QT Dynamics
van Duijvenboden S, Ramírez J, Young WJ, Mifsud B, Orini M, Tinker A, Munroe PB and Lambiase PD
Circulation Genomic and Precision Medicine, Wolters Kluwer vol. 13 (4), e002774-e002774.  
11-06-2020

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
Ntalla I, Weng L-C, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD, Roselli C, Barnes MR, Mifsud B, Warren HR, Hayward C, Marten J, Cranley JJ, Concas MP, Gasparini P, Boutin T, Kolcic I, Polasek O, Rudan I, Araujo NM, Lima-Costa MF, Ribeiro ALP, Souza RP, Tarazona-Santos E, Giedraitis V, Ingelsson E, Mahajan A and Morris AP
Nature Communications, Springer Nature vol. 11 (1) 
21-05-2020

Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval
Ramírez J, van Duijvenboden S, Young WJ, Orini M, Lambiase PD, Munroe PB and Tinker A
American Journal of Human Genetics, Elsevier vol. 106 (6), 764-778.  
07-05-2020

Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not
Williams JL, Paudyal A, Awad S, Nicholson J, Grzesik D, Botta J, Meimaridou E, Maharaj AV, Stewart M, Tinker A, Cox RD and Metherell LA
Life Science Alliance, Life Science Alliance vol. 3 (4) 
25-03-2020

Whole-cell and Perforated Patch-clamp Recordings from Acutely-isolated Murine Sino-atrial Node Cells.
Aziz Q, Nobles M and Tinker A
Bio-Protocol, Bio-Protocol vol. 10 (1) 
01-01-2020

Acute Isolation of Cells from Murine Sino-atrial Node.
Aziz Q, Nobles M and Tinker A
Bio-Protocol, Bio-Protocol vol. 10 (1) 
01-01-2020

ATP-Dependent K + Channels
Tinker A, Aziz Q and Li Y
In Encyclopedia of Molecular Pharmacology, Springer Nature 1-9.  
01-01-2020

Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics
Ramírez J, van Duijvenboden S, Aung N, Laguna P, Pueyo E, Tinker A, Lambiase PD, Orini M and Munroe PB
Circulation: Arrhythmia and Electrophysiology, American Heart Association vol. 12 (10), e007549-e007549.  
01-10-2019

Genetic variants in TRPM7 associated with unexplained stillbirth modify ion channel function
Cartwright JH, Aziz Q, Harmer SC, Thayyil S, Tinker A and Munroe PB
Human Molecular Genetics, Oxford University Press (Oup) vol. 29 (11), 1797-1807.  
19-08-2019

Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages.
Thomas AM, Cabrera CP, Finlay M, Lall K, Nobles M, Schilling RJ, Wood K, Mein CA, Barnes MR, Munroe PB and Tinker A
Physiol Genomics vol. 51 (8), 323-332.  
24-07-2019

Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome.
Finlay M, Bhar-Amato J, Ng K-E, Santos D, Orini M, Vyas V, Taggart P, Grace AA, Huang CL-H, Lambiase PD and Tinker A
Am J Physiol Cell Physiol 
10-07-2019

Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals
Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM, Biggs ML, Biino G, Catamo E, Concas MP, Ding J, Evans DS, Foco L, Grarup N, Lyytikäinen L-P, Mangino M, Mei H, van der Most PJ, Müller-Nurasyid M, Nelson CP, Qian Y, Repetto L, Said MA, Shah N, Schramm K, Vidigal PG, Weiss S and Yao J
Journal of The American College of Cardiology, Elsevier vol. 73 (24), 3118-3131.  
01-06-2019

DSP 突变与致心律失常性心肌病
Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM, Lambiase PD, Tinker A, McKenna WJ and Kelsell DP
British Journal of Dermatology, Oxford University Press (Oup) vol. 180 (5), e169-e169.  
26-04-2019

DSP mutations and arrhythmogenic cardiomyopathy
Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM, Lambiase PD, Tinker A, McKenna WJ and Kelsell DP
British Journal of Dermatology, Oxford University Press (Oup) vol. 180 (5), e157-e157.  
26-04-2019

Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D.
Zhou X, Bueno-Orovio A, Schilling RJ, Kirkby C, Denning C, Rajamohan D, Burrage K, Tinker A, Rodriguez B and Harmer SC
Front Physiol vol. 10, 259-259.  
18-03-2019

Development, in vitro validation and human application of a novel method to identify arrhythmia mechanisms: The stochastic trajectory analysis of ranked signals mapping method
Honarbakhsh S, Hunter RJ, Finlay M, Ullah W, Keating E, Tinker A and Schilling RJ
Journal of Cardiovascular Electrophysiology, Wiley vol. 30 (5), 691-701.  
05-03-2019

Loss‐of‐function desmoplakin I and II mutations underlie dominant arrhythmogenic cardiomyopathy with a hair and skin phenotype
Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM, Lambiase PD, Tinker A, McKenna WJ and Kelsell DP
British Journal of Dermatology, Oxford University Press (Oup) vol. 180 (5), 1114-1122.  
02-01-2019

Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1).
Ang R, Mastitskaya S, Hosford PS, Basalay M, Specterman M, Aziz Q, Li Y, Orini M, Taggart P, Lambiase PD, Gourine A, Tinker A and Gourine AV
Circ Arrhythm Electrophysiol vol. 11 (10), e006740-e006740.  
01-10-2018

23T-wave morphology restitution predicts arrhythmic risk in the UK biobank cohort
Ramírez J, van Duijvenboden S, Orini M, Tinker A, Munroe PB and Lambiase PD
Ep Europace vol. 20 (suppl_4), iv10-iv11.  
01-10-2018

2QT interval and exercise qt dynamics from 58,852 individuals in UK biobank predict ventricular arrhythmias and heart failure
van Duijvenboden S, Ramírez J, Orini M, Tinker A, Munroe PB and Lambiase PD
Ep Europace vol. 20 (suppl_4), iv1-iv1.  
01-10-2018

Defective Vagal Innervation in Murine Tbx1 Mutant Hearts
Calmont A, Anderson N, Suntharalingham JP, Ang R, Tinker A and Scambler PJ
Journal of Cardiovascular Development and Disease, Mdpi vol. 5 (4) 
23-09-2018

ATP‐Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles
Tinker A, Aziz Q, Li Y and Specterman M
, Wiley vol. 8 (4), 1463-1511.  
14-09-2018

Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome.
Bhar-Amato J, Finlay M, Santos D, Orini M, Chaubey S, Vyas V, Taggart P, Grace AA, Huang CL-H, Ben Simon R, Tinker A and Lambiase PD
Circ Arrhythm Electrophysiol vol. 11 (9), e006330-e006330.  
14-09-2018

P5709Hair and cutaneous phenotypes linked to Arrhythmogenic Cardiomyopathy caused by Desmoplakin haploinsufficiency: an additional disease marker
Castelletti S, Maruthappu T, Posafalvi A, Syrris P, O'Toole EA, Green KJ, Tinker A, McKenna WJ and Kelsell DP
European Heart Journal, Oxford University Press (Oup) vol. 39 (suppl_1) 
01-08-2018

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6
Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J, Cappellani S, Van Duijvenboden S, Klena NT, Gabriel GC, Liu X, Gulec C, Grarup N, Haessler J, Hall LM, Iorio A, Isaacs A, Li-Gao R, Lin H, Liu C-T, Lyytikäinen L-P, Marten J, Mei H, Müller-Nurasyid M, Orini M, Padmanabhan S, Radmanesh F and Ramirez J
Genome Biology, Springer Nature vol. 19 (1) 
17-07-2018

A critical role for the ATP-sensitive potassium channel subunit KIR6.1 in the control of cerebral blood flow.
Hosford PS, Christie IN, Niranjan A, Aziz Q, Anderson N, Ang R, Lythgoe MF, Wells JA, Tinker A and Gourine AV
Journal of Cerebral Blood Flow and Metabolism, Sage Publications 
04-06-2018

Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system
Ramírez J, Duijvenboden SV, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A, Lambiase PD and Munroe PB
Nature Communications, Springer Nature vol. 9 (1) 
16-05-2018

CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy
Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M, Harmer SC, Tinker A, Smith JGW, Carrier L, Williams PM, Gaffney D, Eschenhagen T, Hansen A and Denning C
European Heart Journal, Oxford University Press (Oup) vol. 39 (43), 3879-3892.  
08-05-2018

ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia
Aziz Q, Finlay M, Montaigne D, Ojake L, Li Y, Anderson N, Ludwig A and Tinker A
Journal of Biological Chemistry, Elsevier vol. 293 (23), 8912-8921.  
17-04-2018

p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response
Arcidiacono P, Webb CM, Brooke MA, Zhou H, Delaney PJ, Ng K-E, Blaydon DC, Tinker A, Kelsell DP and Chikh A
Nature Communications, Springer Nature vol. 9 (1) 
09-03-2018

Erratum to “The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation” [Pharmacol. Res. 105 (2016) 54–61]
Tinker A, Finlay M, Nobles M and Opel A
Pharmacological Research, Elsevier vol. 129 
01-03-2018

P449The novel long QT syndrome type 1 mutation KCNQ1-p.Thr247dup causes severe channel dysfunction but retains preserved adrenergic regulation
Rathod VS, Harmer SC, Salsbury GA, Bitner-Glindzicz M, Lambiase PD and Tinker A
Ep Europace, Oxford University Press (Oup) vol. 20 (suppl_1), i87-i87.  
01-03-2018

Improving Interpretation of Cardiac Phenotypes and Enhancing Discovery With Expanded Knowledge in the Gene Ontology.
Lovering RC, Roncaglia P, Howe DG, Laulederkind SJF, Khodiyar VK, Berardini TZ, Tweedie S, Foulger RE, Osumi-Sutherland D, Campbell NH, Huntley RP, Talmud PJ, Blake JA, Breckenridge R, Riley PR, Lambiase PD, Elliott PM, Clapp L, Tinker A and Hill DP
Circ Genom Precis Med vol. 11 (2), e001813-e001813.  
13-02-2018

Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K+ currents in adult murine atria
Nobles M, Montaigne D, Sebastian S, Birnbaumer L and Tinker A
American Journal of Physiology - Cell Physiology, American Physiological Society vol. 314 (5), c616-c626.  
17-01-2018

Endothelial biology and ATP-sensitive potassium channels
Aziz Q, Li Y and Tinker A
Channels, Taylor & Francis vol. 12 (1), 45-46.  
01-01-2018

Potassium channels in the sinoatrial node and their role in heart rate control
Aziz Q, Li Y and Tinker A
Channels, Taylor & Francis vol. 12 (1), 356-366.  
01-01-2018

Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths
Munroe PB, Addison S, Abrams DJ, Sebire NJ, Cartwright J, Donaldson I, Cohen MM, Mein C, Tinker A, Harmer SC, Aziz Q, Terry A, Struebig M, Warren HR, Vadgama B, Fowler DJ, Peebles D, Taylor AM, Lally PJ and Thayyil S
Circulation Genomic and Precision Medicine, Wolters Kluwer vol. 11 (1) 
01-01-2018

Correction: Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort.
Orini M, Tinker A, Munroe PB and Lambiase PD
Plos One vol. 13 (2), e0193039-e0193039.  
01-01-2018

Ajmaline blocks I Na and I Kr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters
Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR, Dunkel L, Lambiase PD and Tinker A
Stem Cell Research, Elsevier vol. 25, 233-244.  
07-11-2017

Have the Findings from Clinical Risk Prediction and Trials Any Key Messages for Safety Pharmacology?
TINKER A and Lane J D
Frontiers in Physiology, Frontiers Media vol. 8 
06-11-2017

Mammalian γ2 AMPK regulates intrinsic heart rate.
Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG and Tarasova YS
Nat Commun, Macmillan Publications vol. 8 (1), 1258-1258.  
02-11-2017

Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking.
Royal AA, Tinker A and Harmer SC
Plos One, Public Library of Science vol. 12 (10), e0186293-e0186293.  
11-10-2017

Tissue-Level Cardiac Electrophysiology Studied in Murine Myocardium Using a Microelectrode Array: Autonomic and Thermal Modulation
Lane JD, Montaigne D and Tinker A
 
01-10-2017

Molecular and functional characterization of the endothelial ATP-sensitive potassium channel
Aziz Q, Li Y, Anderson N, Ojake L, Tsisanova E and Tinker A
Journal of Biological Chemistry, Elsevier vol. 292 (43), 17587-17597.  
11-09-2017

Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort.
Orini M, Tinker A, Munroe PB and Lambiase PD
Plos One, Public Library of Science vol. 12 (9), e0183732-e0183732.  
05-09-2017

The mechanisms of ventricular arrhythmia in Chagas disease
Tinker A
International Journal of Cardiology, Elsevier vol. 240, 372-373.  
01-08-2017

Heritability of resting heart rate and association with mortality in middle-aged and elderly twins.
Munroe PB and Tinker A
Heart vol. 104 (1), 6-7.  
04-07-2017

227hERG potassium channel modulation by P127T KCNE1
Zhang Y, Marrion N, Harmer S, Mohamed R, Tinker A and Hancox J
Ep Europace, Oxford University Press (Oup) vol. 19 (suppl_3), iii22-iii22.  
01-06-2017

Discovery of novel heart rate-associated loci using the exome chip
MUNROE PB, Caulfield M, Stirrups K, van den Berg M, Warren H and Cabrera CP
Human Molecular Genetics, Oxford University Press (Oup) 
03-04-2017

Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells
Poliandri A, Miller D, Howard S, Nobles M, Ruiz-Babot G, Harmer S, Tinker A, McKay T, Guasti L and Dunkel L
Molecular and Cellular Endocrinology, Elsevier vol. 447, 12-22.  
21-02-2017

The control of cardiac ventricular excitability by autonomic pathways
Finlay M, Harmer SC and Tinker A
Pharmacology & Therapeutics, Elsevier vol. 174, 97-111.  
14-02-2017

YOUNG INVESTIGATORS COMPETITION
Mellor G, Orini M, Specterman MJ, Sawhney VS, Merghani A, Claridge S, Laksman Z, Gerull B, Simpson C, Klein G, Champagne J, Talajic M, Gardner M, Steinberg C, Janzen M, Arbour L, Green M, Angaran P, Roberts J, Leather R, Sanatani S, Chauhan V, Healey J, Krahn A, Taggart P, Srinivasan N, Hayward M, Lambiase PD, Aziz Q and Finlay MC
Ep Europace, Oxford University Press (Oup) vol. 18 (suppl_2), ii1-ii3.  
01-10-2016

ORAL ABSTRACTS (1)
Champney F, Maddock LJ, Welford J, Kemp J, Allan V, Persidskikh Y, Orini M, Ang R, Workman AJ, Wong L, Honarbakhsh S, Leong KMW, Silberbauer J, O'Nunain S, Gomes J, McCready J, Bostock J, Shaw K, McKenna C, Bailey J, Honarbakhsh S, Casas JP, Wallace J, Hunter R, Schilling R, Perel P, Morley K, Banerjee A, Hemingway H and Mrochak A
Ep Europace, Oxford University Press (Oup) vol. 18 (suppl_2), ii4-ii7.  
01-10-2016

Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension
MUNROE PB
Nature Genetics, Nature Publishing Group 
12-09-2016

The role of GαO‐mediated signaling in the rostral ventrolateral medulla oblongata in cardiovascular reflexes and control of cardiac ventricular excitability
Ang R, Abramowitz J, Birnbaumer L, Gourine AV and Tinker A
Physiological Reports, Wiley vol. 4 (15) 
01-08-2016

GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway.
Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P, Miller D, Harmer S, Poliandri A, Kogaki S, Sakata Y, Dunkel L, Tinker A, Hadjantonakis A-K, Sawa Y, Sasaki H, Ozono K, Suzuki K and Yashiro K
Cell Rep vol. 16 (4), 1026-1038.  
26-07-2016

57-03: How Can a Gain-of-Function Mutation in KCNQ1 Lead to Action Potential Prolongation?
Zhou X, Harmer S, Bueno-Orovio A, Burrage K, Tinker A and Rodriguez B
Ep Europace, Oxford University Press (Oup) vol. 18 (suppl_1), i167-i167.  
01-06-2016

The impact of recent advances in genetics in understanding disease mechanisms underlying the long QT syndromes.
Harmer SC and Tinker A
Biol Chem, De Gruyter vol. 397 (7), 679-693.  
23-02-2016

The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation
Tinker A, Finlay M, Nobles M and Opel A
Pharmacological Research, Elsevier vol. 105, 54-61.  
07-01-2016

Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines
Richards DA, Fletcher SA, Nobles M, Kossen H, Tedaldi L, Chudasama V, Tinker A and Baker JR
Organic & Biomolecular Chemistry, Royal Society of Chemistry (Rsc) vol. 14 (2), 455-459.  
01-01-2016

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop
Rodriguez B, Carusi A, Abi-Gerges N, Ariga R, Britton O, Bub G, Bueno-Orovio A, Burton RAB, Carapella V, Cardone-Noott L, Daniels MJ, Davies MR, Dutta S, Ghetti A, Grau V, Harmer S, Kopljar I, Lambiase P, Lu HR, Lyon A, Minchole A, Muszkiewicz A, Oster J, Paci M, Passini E, Severi S, Taggart P, Tinker A, Valentin J-P and Varro A
Ep Europace, Oxford University Press (Oup) vol. 18 (9), 1287-1298.  
29-11-2015

Genome-wide association studies and contribution to cardiovascular physiology
Munroe PB and Tinker A
Physiological Genomics, American Physiological Society vol. 47 (9), 365-375.  
23-06-2015

Molecular mechanisms of congenital hyperinsulinism due to autosomal dominant mutations in ABCC8
Nessa A, Aziz QH, Thomas AM, Harmer SC, Tinker A and Hussain K
Human Molecular Genetics, Oxford University Press (Oup) vol. 24 (18), 5142-5153.  
19-06-2015

Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling*
Opel A, Nobles M, Montaigne D, Finlay M, Anderson N, Breckenridge R and Tinker A
Journal of Biological Chemistry, Elsevier vol. 290 (31), 19233-19244.  
18-06-2015

Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve
Machhada A, Ang R, Ackland GL, Ninkina N, Buchman VL, Lythgoe MF, Trapp S, Tinker A, Marina N and Gourine AV
Heart Rhythm, Elsevier vol. 12 (11), 2285-2293.  
05-06-2015

iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death
Notari M, Hu Y, Sutendra G, Dedeić Z, Lu M, Dupays L, Yavari A, Carr CA, Zhong S, Opel A, Tinker A, Clarke K, Watkins H, Ferguson DJP, Kelsell DP, de Noronha S, Sheppard MN, Hollinshead M, Mohun TJ and Lu X
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 112 (9), e973-e981.  
17-02-2015

ATP-sensitive potassium channels and vascular function
Aziz Q, Li Y and Tinker A
Channels, Taylor & Francis vol. 9 (1), 3-4.  
02-01-2015

A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging
Fletcher SA, Sin PKB, Nobles M, Årstad E, Tinker A and Baker JR
Organic & Biomolecular Chemistry, Royal Society of Chemistry (Rsc) vol. 13 (37), 9559-9563.  
01-01-2015

Congenital hyperinsulinism: clinical and molecular characterisation of compound heterozygous ABCC8 mutation responsive to Diazoxide therapy
Arya VB, Aziz Q, Nessa A, Tinker A and Hussain K
International Journal of Pediatric Endocrinology, Springer Nature vol. 2014 (1) 
01-12-2014

Connexins in the heart
Lambiase PD and Tinker A
Cell and Tissue Research, Springer Nature vol. 360 (3), 675-684.  
31-10-2014

51Cardiac specific knockout of G-alpha-i2 in a murine model of heart failure.
Lane JD, Abramowitz J, Birnbaumer L and Tinker A
Europace vol. 16 Suppl 3 
01-10-2014

The ATP-sensitive potassium channel subunit, Kir6.1, in vascular smooth muscle plays a major role in blood pressure control.
Aziz Q, Thomas AM, Gomes J, Ang R, Sones WR, Li Y, Ng K-E, Gee L and Tinker A
Hypertension vol. 64 (3), 523-529.  
01-09-2014

Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1.
Harmer SC, Mohal JS, Royal AA, McKenna WJ, Lambiase PD and Tinker A
Biochem J vol. 462 (1), 133-142.  
15-08-2014

The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system.
Tinker A, Aziz Q and Thomas A
Br J Pharmacol vol. 171 (1), 12-23.  
01-01-2014

Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents
Youziel J, Akhbar AR, Aziz Q, Smith MEB, Caddick S, Tinker A and Baker JR
Organic & Biomolecular Chemistry vol. 12 (4), 557-560.  
01-01-2014

Potassium channels regulating the electrical activity of the heart
Tinker A and Harmer SC
In Translational Vascular Medicine: Pathogenesis, Diagnosis, and Treatment 89-109.  
01-11-2013

The in vivo regulation of heart rate in the murine sinoatrial node by stimulatory and inhibitory heterotrimeric G proteins.
Sebastian S, Ang R, Abramowitz J, Weinstein LS, Chen M, Ludwig A, Birnbaumer L and Tinker A
Am J Physiol Regul Integr Comp Physiol vol. 305 (4), R435-R442.  
15-08-2013

The role of GalphaO-mediated signalling in the central nervous mechanisms controlling sympathetic outflow to the heart
Ang R, Birnbaumer L, Gourine AV and Tinker A
European Heart Journal, Oxford University Press (Oup) vol. 34 (suppl_1) 
02-08-2013

Using total internal reflection fluorescence microscopy to observe ion channel trafficking and assembly.
Schwarzer S, Mashanov GI, Molloy JE and Tinker A
Methods Mol Biol vol. 998, 201-208.  
01-01-2013

A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P₂
Telezhkin V, Thomas AM, Harmer SC, Tinker A and Brown DA
Pflugers Archiv-European Journal of Physiology vol. 465 (7), 945-953.  
01-01-2013

Essential Role of the m₂R-RGS6-I_KACh Pathway in Controlling Intrinsic Heart Rate Variability
Posokhova E, Ng D, Opel A, Masuho I, Tinker A, Biesecker LG, Wickman K and Martemyanov KA
Plos One vol. 8 (10) 
01-01-2013

Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3.
Risebro CA, Petchey LK, Smart N, Gomes J, Clark J, Vieira JM, Yanni J, Dobrzynski H, Davidson S, Zuberi Z, Tinker A, Shui B, Tallini YI, Kotlikoff MI, Miquerol L, Schwartz RJ and Riley PR
Circ Res vol. 111 (2), e19-e31.  
06-07-2012

Readthrough of long-QT syndrome type 1 nonsense mutations rescues function but alters the biophysical properties of the channel.
Harmer SC, Mohal JS, Kemp D and Tinker A
Biochem J vol. 443 (3), 635-642.  
01-05-2012

The assembly and targeting of potassium channels
Tinker A
In Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels 
22-03-2012

Regulation of the ATP-sensitive potassium channel subunit, Kir6.2, by a Ca2+-dependent protein kinase C.
Aziz Q, Thomas AM, Khambra T and Tinker A
J Biol Chem vol. 287 (9), 6196-6207.  
24-02-2012

Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding
Telezhkin V, Reilly JM, Thomas AM, Tinker A and Brown DA
Journal of Biological Chemistry vol. 287 (13), 10001-10012.  
01-01-2012

NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system
Maden CH, Gomes J, Schwarz Q, Davidson K, Tinker A and Ruhrberg C
Developmental Biology vol. 369 (2), 277-285.  
01-01-2012

Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study.
Gomes J, Finlay M, Ahmed AK, Ciaccio EJ, Asimaki A, Saffitz JE, Quarta G, Nobles M, Syrris P, Chaubey S, McKenna WJ, TINKER A and Lambiase PD
Eur Heart Journal, Oxford University Press vol. 33 (15), 1942-1953.  
01-01-2012

The Role of Inhibitory G Proteins and Regulators of G Protein Signaling in the in vivo Control of Heart Rate and Predisposition to Cardiac Arrhythmias
Ang R, Opel A and Tinker A
Frontiers in Physiology, Frontiers vol. 3 
01-01-2012

Potassium Channels Regulating the Electrical Activity of the Heart
Tinker A and Harmer SC
In Translational Vascular Medicine, Springer Nature 89-109.  
06-10-2011

The design, synthesis and pharmacological characterization of novel β2‐adrenoceptor antagonists
Hothersall JD, Black J, Caddick S, Vinter JG, Tinker A and Baker JR
British Journal of Pharmacology, Wiley vol. 164 (2), 317-331.  
22-08-2011

In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation
Schumacher FF, Nobles M, Ryan CP, Smith MEB, Tinker A, Caddick S and Baker JR
Bioconjugate Chemistry, American Chemical Society (Acs) vol. 22 (2), 132-136.  
27-01-2011

Sarcolemmal cardiac KATP channels as a target for the cardioprotective effects of the fluorine‐containing pinacidil analogue, flocalin
Voitychuk OI, Strutynskyi RB, Yagupolskii LM, Tinker A, Moibenko OO and Shuba YM
British Journal of Pharmacology, Wiley vol. 162 (3), 701-711.  
12-01-2011

Characterization of a binding site for anionic phospholipids on KCNQ1
Thomas AM, Harmer SC, Khambra T and Tinker A
Journal of Biological Chemistry vol. 286, 2088-2100.  
01-01-2011

Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant ABCC8/KCNJ11 mutations
Kapoor RR, Flanagan SE, James CT, McKiernan J, Thomas AM, Harmer SC, Shield JP, Tinker A, Ellard S and Hussain K
Diab Tologia vol. 54, 2575-2583.  
01-01-2011

In Vitro and In Vivo Cardiomyogenic Differentiation of Amniotic Fluid Stem Cells
Bollini S, Pozzobon M, Nobles M, Riegler J, Dong X, Piccoli M, Chiavegato A, Price AN, Ghionzoli M, Cheung KK, Cabrelle A, O’Mahoney PR, Cozzi E, Sartore S, Tinker A, Lythgoe MF and De Coppi P
Stem Cell Reviews and Reports, Springer Nature vol. 7 (2), 364-380.  
01-12-2010

Retraction Note: The large-conductance Ca2+-activated K+ channel is essential for innate immunity
Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M and Segal AW
Nature, Springer Nature vol. 468 (7320), 122-122.  
01-11-2010

ChemInform Abstract: An Efficient Asymmetric Synthesis of the Potent β‐Blocker ICI‐118,551 Allows the Determination of Enantiomer Dependency on Biological Activity.
Baker JR, Hothersall JD, Fitzmaurice RJ, Tucknott M, Vinter A, Tinker A and Caddick S
Cheminform, Wiley vol. 41 (43), no-no.  
30-09-2010

Do Caveolae Have a Role in the Fidelity and Dynamics of Receptor Activation of G-protein-gated Inwardly Rectifying Potassium Channels?*
Schwarzer S, Nobles M and Tinker A
Journal of Biological Chemistry, Elsevier vol. 285 (36), 27817-27826.  
18-06-2010

Absence of the Inhibitory G-Protein G&agr;i2 Predisposes to Ventricular Cardiac Arrhythmia
Zuberi Z, Nobles M, Sebastian S, Dyson A, Lim SY, Breckenridge R, Birnbaumer L and Tinker A
Circulation Arrhythmia and Electrophysiology, Wolters Kluwer vol. 3 (4), 391-400.  
21-05-2010

The Intracellular Localization and Function of the ATP-Sensitive K+ Channel Subunit Kir6.1
Ng K-E, Schwarzer S, Duchen MR and Tinker A
The Journal of Membrane Biology, Springer Nature vol. 234 (2), 137-147.  
20-03-2010

HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes
Nobles M, Sebastian S and Tinker A
PflüGers Archiv - European Journal of Physiology, Springer Nature vol. 460 (1), 99-108.  
26-02-2010

Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channel
Aziz Q, Thomas A, Khambra T and Tinker A
European Journal of Pharmacology, Elsevier vol. 634 (1-3), 26-32.  
25-02-2010

Direct observation of individual KCNQ1 potassium channels reveals their distinctive diffusive behavior
Mashanov GI, Nobles M, Harmer SC, Molloy JE and Tinker A
Journal of Biological Chemistry vol. 285, 3664-3675.  
01-01-2010

K+ channels in the heart: new insights and therapeutic implications
Tinker A and Harmer SC
Expert Rev Clin Pharmacol vol. 3, 305-319.  
01-01-2010

Mechanisms of disease pathogenesis in long QT syndrome type 5
Harmer SC, Wilson AJ, Aldridge R and Tinker A
Am J Physiol Cell Physiol vol. 298, C263-C273.  
01-01-2010

An efficient asymmetric synthesis of the potent β-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity
Baker JR, Hothersall JD, Fitzmaurice RJ, Tucknott M, Vinter A, Tinker A and Caddick S
Chemical Communications, Royal Society of Chemistry (Rsc) vol. 46 (22), 3953-3954.  
01-01-2010

Ca2+/calcineurin regulation of cloned vascular KATP channels: crosstalk with the protein kinase A pathway
Orie N, Thomas A, Perrino B, Tinker A and Clapp L
British Journal of Pharmacology, Wiley vol. 157 (4), 554-564.  
01-06-2009

Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice
Breckenridge RA, Zuberi Z, Gomes J, Orford R, Dupays L, Felkin LE, Clark JE, Magee AI, Ehler E, Birks EJ, Barton PJR, Tinker A and Mohun TJ
Journal of Molecular and Cellular Cardiology, Elsevier vol. 47 (1), 133-141.  
17-04-2009

The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics
Zuberi Z, Birnbaumer L and Tinker A
Ajp Regulatory Integrative and Comparative Physiology, American Physiological Society vol. 295 (6), r1822-r1830.  
01-10-2008

S12/4 Mitochondria as ATP consumers: the cell biology of the endogenous inhibitory protein, IF1
Campanella M, Tan C, Abramov A, Tinker A and Duchen M
Biochimica Et Biophysica Acta (Bba) - Bioenergetics, Elsevier vol. 1777 
01-07-2008

Monitoring changes in membrane phosphatidylinositol 4,5‐bisphosphate in living cells using a domain from the transcription factor tubby
Quinn KV, Behe P and Tinker A
The Journal of Physiology, Wiley vol. 586 (12), 2855-2871.  
15-06-2008

Differences in the mechanism of metabolic regulation of ATP-sensitive K+ channels containing Kir6.1 and Kir6.2 subunits
Farzaneh T and Tinker A
Cardiovascular Research, Oxford University Press (Oup) vol. 79 (4), 621-631.  
03-06-2008

446 Overexpression of the transcription factor Hand1 causes sudden cardiac death in mice
Breckenridge RA, Zuberi Z, Felkin L, Birks E, Barton P, Tinker A and Mohun T
European Journal of Heart Failure Supplements, Oxford University Press (Oup) vol. 7, 109-109.  
01-06-2008

Regulation of mitochondrial structure and function by IF1, the endogenous inhibitor of the mitochondrial ATPase.
Campanella M, Casswell E, Chong S, Farah Z, Wieckowski MR, Abramov AR, TINKER A and Duchen MR
Cell Metabolism vol. 8 (1), 13-25.  
01-01-2008

Determination of Phosphoinositide Binding to K+ Channel Subunits Using a Protein—Lipid Overlay Assay
Thomas AM and Tinker A
Methods in Molecular Biology, Springer Nature vol. 491, 103-111.  
01-01-2008

IP receptor-dependent activation of PPARγ by stable prostacyclin analogues
Falcetti E, Flavell DM, Staels B, Tinker A, Haworth SG and Clapp LH
Biochemical and Biophysical Research Communications, Elsevier vol. 360 (4), 821-827.  
05-07-2007

Complex ABCC8 DNA variations in congenital hyperinsulinism: lessons from functional studies
Muzyamba M, Farzaneh T, Behe P, Thomas A, Christesen HBT, Brusgaard K, Hussain K and Tinker A
Clinical Endocrinology, Wiley vol. 67 (1), 115-124.  
27-04-2007

PIP2-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: direct on-line assessment of PIP2 depletion by Gq-coupled receptors in single living neurons
Hughes S, Marsh SJ, Tinker A and Brown DA
PflüGers Archiv - European Journal of Physiology, Springer Nature vol. 455 (1), 115-124.  
20-04-2007

The role of abnormal trafficking of KCNE1 in long QT syndrome 5
Harmer SC and Tinker A
Biochemical Society Transactions vol. 35, 1074-1076.  
01-01-2007

Functional Expression of Inward Rectifier Potassium Channels in Cultured Human Pulmonary Smooth Muscle Cells: Evidence for a Major Role of Kir2.4 Subunits
Tennant BP, Cui Y, Tinker A and Clapp LH
The Journal of Membrane Biology, Springer Nature vol. 213 (1), 19-29.  
01-09-2006

Syntaxin-1A Actions on Sulfonylurea Receptor 2A Can Block Acidic pH-induced Cardiac KATP Channel Activation*
Kang Y, Ng B, Leung Y-M, He Y, Xie H, Lodwick D, Norman RI, Tinker A, Tsushima RG and Gaisano HY
Journal of Biological Chemistry, Elsevier vol. 281 (28), 19019-19028.  
03-05-2006

Differential Phosphoinositide Binding to Components of the G Protein-Gated K+ Channel
Thomas AM, Brown SG, Leaney JL and Tinker A
The Journal of Membrane Biology, Springer Nature vol. 211 (1), 43-53.  
01-05-2006

The selective interactions and functions of regulators of G-protein signalling
Tinker A
Seminars in Cell and Developmental Biology, Elsevier vol. 17 (3), 377-382.  
03-04-2006

Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells
Nobles M, Benians A and Tinker A
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 102 (51), 18706-18711.  
13-12-2005

Abnormal KCNQ1 trafficking influences disease pathogenesis in hereditary long QT syndromes (LQT1)
Wilson AJ, Quinn KV, Graves FM, Bitner-Glindzicz M and Tinker A
Cardiovascular Research, Oxford University Press (Oup) vol. 67 (3), 476-486.  
15-08-2005

PKC-δ sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells
Brown SG, Thomas A, Dekker LV, Tinker A and Leaney JL
American Journal of Physiology - Cell Physiology, American Physiological Society vol. 289 (3), c543-c556.  
27-04-2005

Regulators of G-protein Signaling Form a Quaternary Complex with the Agonist, Receptor, and G-protein A NOVEL EXPLANATION FOR THE ACCELERATION OF SIGNALING ACTIVATION KINETICS*
Benians A, Nobles M, Hosny S and Tinker A
Journal of Biological Chemistry, Elsevier vol. 280 (14), 13383-13394.  
27-01-2005

Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature
Morrissey A, Rosner E, Lanning J, Parachuru L, Dhar Chowdhury P, Han S, Lopez G, Tong X, Yoshida H, Nakamura TY, Artman M, Giblin JP, Tinker A and Coetzee WA
Bmc Physiology, Springer Nature vol. 5 (1) 
12-01-2005

Multisite Phosphorylation Mechanism for Protein Kinase A Activation of the Smooth Muscle ATP-Sensitive K+ Channel
Quinn KV, Giblin JP and Tinker A
Circulation Research, Wolters Kluwer vol. 94 (10), 1359-1366.  
15-04-2004

Rapid desensitization of G protein-gated inwardly rectifying K+ currents is determined by G protein cycle
Leaney JL, Benians A, Brown S, Nobles M, Kelly D and Tinker A
American Journal of Physiology - Cell Physiology, American Physiological Society vol. 287 (1), c182-c191.  
10-03-2004

The large-conductance Ca2+-activated K+ channel is essential for innate immunity
Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M and Segal AW
Nature, Springer Nature vol. 427 (6977), 853-858.  
01-02-2004

Do Anionic Phospholipids Serve as Cofactors or Second Messengers for the Regulation of Activity of Cloned ATP-Sensitive K+ Channels?
Quinn KV, Cui Y, Giblin JP, Clapp LH and Tinker A
Circulation Research, Wolters Kluwer vol. 93 (7), 646-655.  
11-09-2003

Different molecular sites of action for the KATP channel inhibitors, PNU‐99963 and PNU‐37883A
Cui Y, Tinker A and Clapp LH
British Journal of Pharmacology, Wiley vol. 139 (1), 122-128.  
01-05-2003

Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K+ channels
Benians A, Leaney JL and Tinker A
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 100 (10), 6239-6244.  
28-04-2003

The Dynamics of Formation and Action of the Ternary Complex Revealed in Living Cells Using a G-protein-gated K+ Channel as a Biosensor*
Benians A, Leaney JL, Milligan G and Tinker A
Journal of Biological Chemistry, Elsevier vol. 278 (12), 10851-10858.  
14-01-2003

The cytoplasmic C‐terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking
Giblin JP, Quinn K and Tinker A
The Febs Journal, Wiley vol. 269 (21), 5303-5313.  
17-10-2002

KATP Channel Gene Expression Is Induced by Urocortin and Mediates Its Cardioprotective Effect
Lawrence KM, Chanalaris A, Scarabelli T, Hubank M, Pasini E, Townsend PA, Comini L, Ferrari R, Tinker A, Stephanou A, Knight RA and Latchman DS
Circulation, Wolters Kluwer vol. 106 (12), 1556-1562.  
17-09-2002

A Novel Strategy to Engineer Functional Fluorescent Inhibitory G-protein α Subunits*
Leaney JL, Benians A, Graves FM and Tinker A
Journal of Biological Chemistry, Elsevier vol. 277 (32), 28803-28809.  
04-06-2002

Differential Effects of Stable Prostacyclin Analogs on Smooth Muscle Proliferation and Cyclic AMP Generation in Human Pulmonary Artery
Clapp LH, Finney P, Turcato S, Tran S, Rubin LJ and Tinker A
American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society vol. 26 (2), 194-201.  
01-02-2002

Assembly Limits the Pharmacological Complexity of ATP-sensitive Potassium Channels*
Giblin JP, Cui Y, Clapp LH and Tinker A
Journal of Biological Chemistry, Elsevier vol. 277 (16), 13717-13723.  
01-02-2002

The Molecular Composition of KATP Channels in Human Pulmonary Artery Smooth Muscle Cells and Their Modulation by Growth
Cui Y, Tran S, Tinker A and Clapp LH
American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society vol. 26 (1), 135-143.  
01-01-2002

A spectrum of functional effects for disease causing mutations in the Jervell and Lange-Nielsen syndrome
Huang L, Bitner-Glindzicz M, Tranebjærg L and Tinker A
Cardiovascular Research, Oxford University Press (Oup) vol. 51 (4), 670-680.  
01-09-2001

Regulation of a G protein‐gated inwardly rectifying K+ channel by a Ca2+‐independent protein kinase C
Leaney JL, Dekker LV and Tinker A
The Journal of Physiology, Wiley vol. 534 (2), 367-379.  
01-07-2001

A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits
Cui Y, Giblin JP, Clapp LH and Tinker A
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 98 (2), 729-734.  
02-01-2001

Functional Expression of the Pore Forming Subunit of the ATP-Sensitive Potassium Channel in Saccharomyces cerevisiae
Graves FM and Tinker A
Biochemical and Biophysical Research Communications, Elsevier vol. 272 (2), 403-409.  
01-06-2000

The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel
Leaney JL and Tinker A
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 97 (10), 5651-5656.  
25-04-2000

The G Protein α Subunit Has a Key Role in Determining the Specificity of Coupling to, but Not the Activation of, G Protein-gated Inwardly Rectifying K+ Channels*
Leaney JL, Milligan G and Tinker A
Journal of Biological Chemistry, Elsevier vol. 275 (2), 921-929.  
01-01-2000

The Molecular Assembly of ATP-sensitive Potassium Channels DETERMINANTS ON THE PORE FORMING SUBUNIT*
Giblin JP, Leaney JL and Tinker A
Journal of Biological Chemistry, Elsevier vol. 274 (32), 22652-22659.  
01-08-1999

Chapter 9 The Assembly of Inwardly Rectifying Potassium Channels
Tinker A and Jan LY
Current Topics in Membranes, Elsevier vol. 46, 143-158.  
01-01-1999

Potassium channels in the vasculature
Lucie H and Tinker A
Current Opinion in Nephrology & Hypertension, Wolters Kluwer vol. 7 (1), 83-98.  
01-01-1998

Structural Components of Ryanodine Responsible for Modulation of Sarcoplasmic Reticulum Calcium Channel Function †
Welch W, Williams AJ, Tinker A, Mitchell KE, Deslongchamps P, Lamothe J, Gerzon K, Bidasee KR, Besch HR, Airey JA, Sutko JL and Ruest L
Biochemistry, American Chemical Society (Acs) vol. 36 (10), 2939-2950.  
01-03-1997

Regions Responsible for the Assembly of Inwardly Rectifying Potassium Channels
Tinker A, Jan YN and Jan LY
Cell, Elsevier vol. 87 (5), 857-868.  
01-11-1996

Electrophysiological effects of ryanodine derivatives on the sheep cardiac sarcoplasmic reticulum calcium-release channel
Tinker A, Sutko JL, Ruest L, Deslongchamps P, Welch W, Airey JA, Gerzon K, Bidasee KR, Besch HR and Williams AJ
Biophysical Journal, Elsevier vol. 70 (5), 2110-2119.  
01-05-1996

Measuring the length of the pore of the sheep cardiac sarcoplasmic reticulum calcium-release channel using related trimethylammonium ions as molecular calipers
Tinker A and Williams AJ
Biophysical Journal, Elsevier vol. 68 (1), 111-120.  
01-01-1995

How does ryanodine modify ion handling in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel?
Lindsay AR, Tinker A and Williams AJ
The Journal of General Physiology, Rockefeller University Press vol. 104 (3), 425-447.  
01-09-1994

Probing the structure of the conduction pathway of the sheep cardiac sarcoplasmic reticulum calcium-release channel with permeant and impermeant organic cations.
Tinker A and Williams AJ
The Journal of General Physiology, Rockefeller University Press vol. 102 (6), 1107-1129.  
01-12-1993

Using large organic cations to probe the nature of ryanodine modification in the sheep cardiac sarcoplasmic reticulum calcium release channel
Tinker A and Williams AJ
Biophysical Journal, Elsevier vol. 65 (4), 1678-1683.  
01-10-1993

Cation conduction in the calcium release channel of the cardiac sarcoplasmic reticulum under physiological and pathophysiological conditions
Tinker A, Lindsay ARG and Williams AJ
Cardiovascular Research, Oxford University Press (Oup) vol. 27 (10), 1820-1825.  
01-10-1993

Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel
Tinker A and Williams AJ
Biophysical Journal, Elsevier vol. 65 (2), 852-864.  
01-08-1993

Divalent cation conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum.
Tinker A and Williams AJ
The Journal of General Physiology, Rockefeller University Press vol. 100 (3), 479-493.  
01-09-1992

A model for ionic conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum.
Tinker A, Lindsay AR and Williams AJ
The Journal of General Physiology, Rockefeller University Press vol. 100 (3), 495-517.  
01-09-1992

Large tetraalkyl ammonium cations produce a reduced conductance state in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel
Tinker A, Lindsay AR and Williams AJ
Biophysical Journal, Elsevier vol. 61 (5), 1122-1132.  
01-05-1992

Block of the sheep cardiac sarcoplasmic reticulum Ca2+-release channel by tetra-alkyl ammonium cations
Tinker A, Lindsay ARG and Williams AJ
The Journal of Membrane Biology, Springer Nature vol. 127 (2), 149-159.  
01-04-1992