Van Duijvenboden S, Nicholson G, Smith-Byrne K, Portas L, Atkins J, Ramirez J, Orini M, Young WJ, Tinker A, Lambiase PD, Munroe PB and Doherty A (2024). The genetic architecture of exercise-induced ventricular ectopy. Oxford University Press (OUP)  European Heart Journal  vol. 45, (Supplement_1)  

Young W, Sanghvi MM, Ramirez J, Orini M, Tinker A, Warren HR, Lambiase PD and Munroe PB (2024). Circulating metabolites associate with the QT interval in individuals without prevalent cardiovascular disease. Oxford University Press (OUP)  European Heart Journal  vol. 45, (Supplement_1)  

Ramirez J, Martinez JP, Van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB and Miguel A (2024). Long-term time-to-ventricular arrhythmic event prediction using a deep learning based model on the electrocardiogram signal. Oxford University Press (OUP)  European Heart Journal  vol. 45, (Supplement_1)  

Young WJ, van der Most PJ, Bartz TM, Bos MM, Biino G, Duong T, Foco L, Lominchar JT, Müller-Nurasyid M, Nardone GG, Pecori A, Ramirez J, Repetto L, Schramm K, Shen X, van Duijvenboden S, van Heemst D, Weiss S, Yao J, Benjamins J-W, Alonso A, Spedicati B, Biggs ML, Brody JA, Dörr M, Fuchsberger C, Gögele M, Guo X, Ikram MA and Jukema JW (2024). Genome-Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants. Wolters Kluwer  Journal of the American Heart Association  vol. 13, (17)  

Vyas V, Sandhar B, Keane JM, Wood EG, Blythe H, Jones A, Shahaj E, Fanti S, Williams J, Metic N, Efremova M, Ng HL, Nageswaran G, Byrne S, Feldhahn N, Marelli-Berg F, Chain B, Tinker A, Finlay MC and Longhi MP (2024). Tissue-resident memory T cells in epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in atrial fibrillation. Springer Nature  Nature Cardiovascular Research  vol. 3, (9) 1067-1082.  

Ramírez J, van Duijvenboden S, Young WJ, Chen Y, Usman T, Orini M, Lambiase PD, Tinker A, Bell CG, Morris AP and Munroe PB (2024). Fine mapping of candidate effector genes for heart rate. Springer Nature  Human Genetics  vol. 143, (9-10) 1207-1221.  

Tsisanova E, Nobles M, Sebastian S, Ng K-E, Thomas A, Weinstein LS, Munroe PB and Tinker A (2024). The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart. Elsevier  Journal of Biological Chemistry  vol. 300, (7)  

Brennan S, Chen S, Makwana S, Esposito S, McGuinness LR, Alnaimi AIM, Sims MW, Patel M, Aziz Q, Ojake L, Roberts JA, Sharma P, Lodwick D, Tinker A, Barrett‐Jolley R, Dart C and Rainbow RD (2024). Identification and characterisation of functional Kir6.1‐containing ATP‐sensitive potassium channels in the cardiac ventricular sarcolemmal membrane. Wiley  British Journal of Pharmacology  vol. 181, (18) 3380-3400.  

Kellett DO, Aziz Q, Humphries JD, Korsak A, Braga A, Del Arroyo AG, Crescente M, Tinker A, Ackland GL and Gourine AV (2024). Transcriptional response of the heart to vagus nerve stimulation. Physiol Genomics  vol. 56, (2) 167-178.  

Kellett DO, Aziz Q, Humphries JD, Korsak A, Braga A, Gutierrez Del Arroyo A, Crescente M, Tinker A, Ackland GL and Gourine AV (2023). Transcriptional response of the heart to vagus nerve stimulation. Physiol Genomics   

Ramirez J, Martinez JP, Van Duijvenboden S, Tinker A, Lambiase P, Orini M, Munroe PB and Miguel A (2023). Combining hypothesis-driven ECG indices with machine learning improves ventricular arrhythmic risk prediction in a low-risk population. Oxford University Press (OUP)  European Heart Journal  vol. 44, (Supplement_2)  

Orini M, Van Duijvenboden S, Young WJ, Ramirez J, Jones AR, Tinker A, Munroe PB and Lambiase PD (2023). Ultra-short heart rate variability over 15 seconds is associated with increased long-term risk of cardiovascular disease. Oxford University Press (OUP)  European Heart Journal  vol. 44, (Supplement_2)  

Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Hughes AD, Tinker A, Munroe PB and Lambiase PD (2023). Long-term association of ultra-short heart rate variability with cardiovascular events. Springer Nature  Scientific Reports  vol. 13, (1)  

Sanpawithayakul K, Mistry A, Rai A, Funge G, Sebastian S, Solomou A, Lillina VM, Gaston-Massuet C, Tinker A, Begalli F and Korbonits M (2023). Hindering the progression of cardiac fibrosis in acromegaly - the role of somatostatin receptor ligands. Bioscientifica  Endocrine Abstracts   

Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P, Miller D, Harmer S, Poliandri A, Kogaki S, Sakata Y, Dunkel L, Tinker A, Hadjantonakis A-K, Sawa Y, Sasaki H, Ozono K, Suzuki K and Yashiro K (2023). GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway. Elsevier  Cell Reports  vol. 42, (11)  

van Duijvenboden S, Ramírez J, Orini M, Aung N, Petersen SE, Doherty A, Tinker A, Munroe PB and Lambiase PD (2023). Prognostic Significance of Different Ventricular Ectopic Burdens During Submaximal Exercise in Asymptomatic UK Biobank Subjects. Wolters Kluwer  Circulation  vol. 148, (24) 1932-1944.  

Specterman MJ, Aziz Q, Li Y, Anderson NA, Ojake L, Ng K-E, Thomas AM, Finlay MC, Schilling RJ, Lambiase PD and Tinker A (2023). Hypoxia Promotes Atrial Tachyarrhythmias via Opening of ATP-Sensitive Potassium Channels. Wolters Kluwer  Circulation Arrhythmia and Electrophysiology  vol. 16, (9)  

Williams JL, Smith CJ, Mastroianni G, Stewart M, Cutillas P, Tinker A and Metherell L (2023). Abstract P2043: Loss Of Full-length Mylk3 Causes Dilated Cardiomyopathy Via A Myl2-independent Mechanism. Wolters Kluwer  Circulation Research  vol. 133, (Suppl_1)  

Korsak A, Kellett DO, Aziz Q, Anderson C, D’Souza A, Tinker A, Ackland GL and Gourine AV (2023). Immediate and sustained increases in the activity of vagal preganglionic neurons during exercise and after exercise training. Oxford University Press (OUP)  Cardiovascular Research  vol. 119, (13) 2329-2341.  

Zawada D, Kornherr J, Meier AB, Santamaria G, Dorn T, Nowak-Imialek M, Ortmann D, Zhang F, Lachmann M, Dreßen M, Ortiz M, Mascetti VL, Harmer SC, Nobles M, Tinker A, De Angelis MT, Pedersen RA, Grote P, Laugwitz K-L, Moretti A and Goedel A (2023). Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools. Springer Nature  Nature Communications  vol. 14, (1)  

Young WJ, Haessler J, Benjamins J-W, Repetto L, Yao J, Isaacs A, Harper AR, Ramirez J, Garnier S, van Duijvenboden S, Baldassari AR, Concas MP, Duong T, Foco L, Isaksen JL, Mei H, Noordam R, Nursyifa C, Richmond A, Santolalla ML, Sitlani CM, Soroush N, Thériault S, Trompet S, Aeschbacher S, Ahmadizar F, Alonso A, Brody JA, Campbell A and Correa A (2023). Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease. Springer Nature  Nature Communications  vol. 14, (1)  

Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Tinker A, Munroe PB and Lambiase PD (2023). Premature atrial and ventricular contractions detected on wearable-format electrocardiograms and prediction of cardiovascular events. Oxford University Press (OUP)  European Heart Journal - Digital Health  vol. 4, (2) 112-118.  

Bercea C, Limbu R, Behnam K, Ng K-E, Aziz Q, Tinker A, Tamagnini F, Cottrell GS and McNeish AJ (2022). Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels. Frontiers  Frontiers in Physiology  vol. 13,  

Kwek X-Y, Hall AR, Lim W-W, Katwadi K, Soong PL, Grishina E, Lin K-H, Crespo-Avilan G, Yap EP, Ismail NI, Chinda K, Chung YY, Wei H, Shim W, Montaigne D, Tinker A, Ong S-B and Hausenloy DJ (2022). Role of cardiac mitofusins in cardiac conduction following simulated ischemia–reperfusion. Springer Nature  Scientific Reports  vol. 12, (1)  

Wilson D, Tinker A and Iskratsch T (2022). Investigating cardiomyocyte dysfunction in dilated cardiomyopathy associated with Duchenne muscular dystrophy. Elsevier  Journal of Molecular and Cellular Cardiology  vol. 173,  

Sebastian S, Weinstein LS, Ludwig A, Munroe P and Tinker A (2022). Slowing Heart Rate Protects Against Pathological Cardiac Hypertrophy. Oxford University Press (OUP)  Function  vol. 4, (1)  

Iskratsch T, Wilson D and Tinker A (2022). The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction. Nature Research  Communications Biology   

Young WJ, Lahrouchi N, Isaacs A, Duong T, Foco L, Ahmed F, Brody JA, Salman R, Noordam R, Benjamins J-W, Haessler J, Lyytikäinen L-P, Repetto L, Concas MP, van den Berg ME, Weiss S, Baldassari AR, Bartz TM, Cook JP, Evans DS, Freudling R, Hines O, Isaksen JL, Lin H, Mei H, Moscati A, Müller-Nurasyid M, Nursyifa C, Qian Y and Richmond A (2022). Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways. Springer Nature  Nature Communications  vol. 13, (1)  

Ramírez J, Kiviniemi A, van Duijvenboden S, Tinker A, Lambiase PD, Junttila J, Perkiömäki JS, Huikuri HV, Orini M and Munroe PB (2022). ECG T‐Wave Morphologic Variations Predict Ventricular Arrhythmic Risk in Low‐ and Moderate‐Risk Populations. Wolters Kluwer  Journal of the American Heart Association  vol. 11, (17)  

Williams JL, Paudyal A, Stewart M, Cutillas P, Tinker A and Metherell L (2022). Abstract P2005: Loss Of Full-length Mylk3 Causes Dilated Cardiomyopathy Via A MYL2-independent Mechanism. Wolters Kluwer  Circulation Research  vol. 131, (Suppl_1) ap2005-ap2005.  

Ramírez J, Van Duijvenboden S, Young W, Tinker A, Lambiase P, Orini M and Munroe P (2022). Prediction of coronary artery disease and major adverse cardiovascular events using clinical and genetic risk scores for cardiovascular risk factors. Elsevier  Atherosclerosis  vol. 355, 3-4.  

Ramírez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M and Munroe PB (2022). Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors. Circulation Genomic and Precision Medicine  vol. 15, (5) e003441-e003441.  

Christensen SL, Rasmussen RH, La Cour S, Ernstsen C, Hansen TF, Kogelman LJ, Lauritzen SP, Guzaite G, Styrishave B, Janfelt C, Christensen ST, Aziz Q, Tinker A, Jansen-Olesen I, Olesen J and Kristensen DM (2021). Smooth muscle ATP-sensitive potassium channels mediate migraine-relevant hypersensitivity in mouse models. SAGE Publications  Cephalalgia  vol. 42, (2) 93-107.  

Williams J, paudyal A, Stewart M, Cutillas P, Cox RD, Tinker A and Metherell L (2021). Abstract 14037: A Shorter Myosin Light Chain Kinase 3 Isoform Maintains Myosin Light Chain 2 Phosphorylation but Does Not Attenuate the Dilated Cardiomyopathy Seen in C57BL/6N Mice. Wolters Kluwer  Circulation  vol. 144, (Suppl_1) a14037-a14037.  

Tinker A (2021). Does knowledge of the mutation in hereditary long QT syndrome aid risk stratification? Oxford University Press (OUP)  European Heart Journal  vol. 42, (46) 4756-4758.  

Rathod VSHS, Harmer S, Royal A, Aziz Q, Lambiase P and Tinker A (2021). B-PO02-015 ENHANCING MUTANT I KSCHANNEL ACTIVITY BY ALTERING ENDOGENOUS PIP2 LEVELS AND ITS INTERACTION WITH PKA SIGNALLING PATHWAY. Elsevier  Heart Rhythm  vol. 18, (8)  

van Duijvenboden S, Ramírez J, Young WJ, Orini M, Mifsud B, Tinker A, Lambiase PD and Munroe PB (2021). Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders. Oxford University Press (OUP)  Human Molecular Genetics  vol. 30, (24) 2513-2523.  

Ng KE, Delaney PJ, Thenet D, Murtough S, Webb CM, Zaman N, Tsisanova E, Mastroianni G, Walker SLM, Westaby JD, Pennington DJ, Pink R, Kelsell DP and Tinker A (2021). Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathy. Springer Nature  Cell and Tissue Research  vol. 386, (1) 79-98.  

Rathod V, Harmer S, Royal A, Aziz Q, Lambiase P and Tinker A (2021). Enhancing mutant IKS channel activity by increasing endogenous PIP2 levels and its interaction with PKA signalling pathway. Oxford University Press (OUP)  EP Europace  vol. 23, (Supplement_3)  

Young WJ, Warren HR, Mook-Kanamori DO, Ramírez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D, Lambiase PD, Jukema JW, Munroe PB and Noordam R (2021). Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization. Wolters Kluwer  Circulation Genomic and Precision Medicine  vol. 14, (3)  

Sebastian S, Nobles M, Tsisanova E, Ludwig A, Munroe PB and Tinker A (2021). The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate. American Physiological Society  Physiological Genomics  vol. 53, (4) 150-159.  

Mensah-Kane J, Schmidt AF, Hingorani AD, Finan C, Chen Y, van Duijvenboden S, Orini M, Lambiase PD, Tinker A, Marouli E, Munroe PB and Ramírez J (2021). No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis. Frontiers  Frontiers in Genetics  vol. 12,  

Ramírez J, van Duijvenboden S, Young WJ, Orini M, Jones AR, Lambiase PD, Munroe PB and Tinker A (2021). Analysing electrocardiographic traits and predicting cardiac risk in UK biobank. SAGE Publications  JRSM Cardiovascular Disease  vol. 10,  

Li Y, Aziz Q and Tinker A (2021). The Pharmacology of ATP-Sensitive K+ Channels (KATP). Springer Nature  Handbook of Experimental Pharmacology  vol. 267, 357-378.  

Tinker A, Aziz Q and Li Y (2021). ATP-Dependent K+ Channels. Encyclopedia of Molecular Pharmacology  Springer Nature   

Ramírez J and Tinker A (2020). Ventricular Restitution Predicts Paroxysmal Atrial Fibrillation in Horses. Oxford University Press (OUP)  Function  vol. 2, (1)  

Young WJ, van Duijvenboden S, Ramírez J, Jones A, Tinker A, Munroe PB, Lambiase PD and Orini M (2020). A Method to Minimise the Impact of ECG Marker Inaccuracies on the Spatial QRS-T angle: Evaluation on 1,512 Manually Annotated ECGs. Elsevier  Biomedical Signal Processing and Control  vol. 64,  

Balestrini S, Mikati MA, Garcia-Roves RA, Carboni M, Hunanyan AS, Kherallah B, McLean M, Prange L, De Grandis E, Gagliardi A, Pisciotta L, Stagnaro M, Veneselli E, Campistol J, Fons C, Pias-Peleteiro L, Brashear A, Miller C, Samoes R, Brankovic V, Padiath QS, Potic A, Pilch J, Vezyroglou K, Bye AME, Davis AM, Ryan MM, Semsarian C, Hollingsworth G and Scheffer IE (2020). Cardiac phenotype in ATP1A3-related syndromes: A multicentre cohort study. American Academy of Neurology  Neurology   

Li Y, Aziz Q, Anderson N, Ojake L and Tinker A (2020). Endothelial ATP-Sensitive Potassium Channel Protects Against the Development of Hypertension and Atherosclerosis. American Heart Association  Hypertension  HYPERTENSIO-HYPERTENSIO.  

Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S, Hobbs AJ, Thiemermann C and Tinker A (2020). Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia. Springer Science and Business Media LLC  Journal of Molecular Medicine   

Villar D, Frost S, Deloukas P and Tinker A (2020). The contribution of non-coding regulatory elements to cardiovascular disease. The Royal Society  Open Biology  vol. 10, (7) 200088-200088.  

Aziz Q and Tinker A (2020). The Pathophysiology of Cardiac Abnormalities in Cantu Syndrome: Perspective on The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome. OUP  Function  vol. 1, (1) zqaa005-zqaa005.  

van Duijvenboden S, Ramírez J, Young WJ, Mifsud B, Orini M, Tinker A, Munroe PB and Lambiase PD (2020). Genetic Basis and Prognostic Value of Exercise QT Dynamics. Wolters Kluwer  Circulation Genomic and Precision Medicine  vol. 13, (4) e002774-e002774.  

Ntalla I, Weng L-C, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD, Roselli C, Barnes MR, Mifsud B, Warren HR, Hayward C, Marten J, Cranley JJ, Concas MP, Gasparini P, Boutin T, Kolcic I, Polasek O, Rudan I, Araujo NM, Lima-Costa MF, Ribeiro ALP, Souza RP, Tarazona-Santos E, Giedraitis V, Ingelsson E, Mahajan A and Morris AP (2020). Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Springer Nature  Nature Communications  vol. 11, (1)  

Ramírez J, van Duijvenboden S, Young WJ, Orini M, Lambiase PD, Munroe PB and Tinker A (2020). Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval. Elsevier  American Journal of Human Genetics  vol. 106, (6) 764-778.  

Williams JL, Paudyal A, Awad S, Nicholson J, Grzesik D, Botta J, Meimaridou E, Maharaj AV, Stewart M, Tinker A, Cox RD and Metherell LA (2020). Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not. Life Science Alliance  Life Science Alliance  vol. 3, (4)  

Aziz Q, Nobles M and Tinker A (2020). Whole-cell and Perforated Patch-clamp Recordings from Acutely-isolated Murine Sino-atrial Node Cells. Bio-Protocol  Bio-protocol  vol. 10, (1)  

Aziz Q, Nobles M and Tinker A (2020). Acute Isolation of Cells from Murine Sino-atrial Node. Bio-Protocol  Bio-protocol  vol. 10, (1)  

Tinker A, Aziz Q and Li Y (2020). ATP-Dependent K + Channels. Encyclopedia of Molecular Pharmacology  Springer Nature   

Ramírez J, van Duijvenboden S, Aung N, Laguna P, Pueyo E, Tinker A, Lambiase PD, Orini M and Munroe PB (2019). Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics. American Heart Association  Circulation: Arrhythmia and Electrophysiology  vol. 12, (10) e007549-e007549.  

Cartwright JH, Aziz Q, Harmer SC, Thayyil S, Tinker A and Munroe PB (2019). Genetic variants in TRPM7 associated with unexplained stillbirth modify ion channel function. Oxford University Press (OUP)  Human Molecular Genetics  vol. 29, (11) 1797-1807.  

Thomas AM, Cabrera CP, Finlay M, Lall K, Nobles M, Schilling RJ, Wood K, Mein CA, Barnes MR, Munroe PB and Tinker A (2019). Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages. Physiol Genomics  vol. 51, (8) 323-332.  

Finlay M, Bhar-Amato J, Ng K-E, Santos D, Orini M, Vyas V, Taggart P, Grace AA, Huang CL-H, Lambiase PD and Tinker A (2019). Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome. Am J Physiol Cell Physiol   

Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM, Biggs ML, Biino G, Catamo E, Concas MP, Ding J, Evans DS, Foco L, Grarup N, Lyytikäinen L-P, Mangino M, Mei H, van der Most PJ, Müller-Nurasyid M, Nelson CP, Qian Y, Repetto L, Said MA, Shah N, Schramm K, Vidigal PG, Weiss S and Yao J (2019). Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals. Elsevier  Journal of the American College of Cardiology  vol. 73, (24) 3118-3131.  

Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM, Lambiase PD, Tinker A, McKenna WJ and Kelsell DP (2019). DSP 突变与致心律失常性心肌病. Oxford University Press (OUP)  British Journal of Dermatology  vol. 180, (5) e169-e169.  

Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM, Lambiase PD, Tinker A, McKenna WJ and Kelsell DP (2019). DSP mutations and arrhythmogenic cardiomyopathy. Oxford University Press (OUP)  British Journal of Dermatology  vol. 180, (5) e157-e157.  

Zhou X, Bueno-Orovio A, Schilling RJ, Kirkby C, Denning C, Rajamohan D, Burrage K, Tinker A, Rodriguez B and Harmer SC (2019). Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D. Front Physiol  vol. 10, 259-259.  

Honarbakhsh S, Hunter RJ, Finlay M, Ullah W, Keating E, Tinker A and Schilling RJ (2019). Development, in vitro validation and human application of a novel method to identify arrhythmia mechanisms: The stochastic trajectory analysis of ranked signals mapping method. Wiley  Journal of Cardiovascular Electrophysiology  vol. 30, (5) 691-701.  

Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM, Lambiase PD, Tinker A, McKenna WJ and Kelsell DP (2019). Loss‐of‐function desmoplakin I and II mutations underlie dominant arrhythmogenic cardiomyopathy with a hair and skin phenotype. Oxford University Press (OUP)  British Journal of Dermatology  vol. 180, (5) 1114-1122.  

Ang R, Mastitskaya S, Hosford PS, Basalay M, Specterman M, Aziz Q, Li Y, Orini M, Taggart P, Lambiase PD, Gourine A, Tinker A and Gourine AV (2018). Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1). Circ Arrhythm Electrophysiol  vol. 11, (10) e006740-e006740.  

Ramírez J, van Duijvenboden S, Orini M, Tinker A, Munroe PB and Lambiase PD (2018). 23T-wave morphology restitution predicts arrhythmic risk in the UK biobank cohort. EP Europace  vol. 20, (suppl_4) iv10-iv11.  

van Duijvenboden S, Ramírez J, Orini M, Tinker A, Munroe PB and Lambiase PD (2018). 2QT interval and exercise qt dynamics from 58,852 individuals in UK biobank predict ventricular arrhythmias and heart failure. EP Europace  vol. 20, (suppl_4) iv1-iv1.  

Calmont A, Anderson N, Suntharalingham JP, Ang R, Tinker A and Scambler PJ (2018). Defective Vagal Innervation in Murine Tbx1 Mutant Hearts. MDPI  Journal of Cardiovascular Development and Disease  vol. 5, (4)  

Tinker A, Aziz Q, Li Y and Specterman M (2018). ATP‐Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles. Wiley   

Bhar-Amato J, Finlay M, Santos D, Orini M, Chaubey S, Vyas V, Taggart P, Grace AA, Huang CL-H, Ben Simon R, Tinker A and Lambiase PD (2018). Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome. Circ Arrhythm Electrophysiol  vol. 11, (9) e006330-e006330.  

Castelletti S, Maruthappu T, Posafalvi A, Syrris P, O'Toole EA, Green KJ, Tinker A, McKenna WJ and Kelsell DP (2018). P5709Hair and cutaneous phenotypes linked to Arrhythmogenic Cardiomyopathy caused by Desmoplakin haploinsufficiency: an additional disease marker. Oxford University Press (OUP)  European Heart Journal  vol. 39, (suppl_1)  

Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J, Cappellani S, Van Duijvenboden S, Klena NT, Gabriel GC, Liu X, Gulec C, Grarup N, Haessler J, Hall LM, Iorio A, Isaacs A, Li-Gao R, Lin H, Liu C-T, Lyytikäinen L-P, Marten J, Mei H, Müller-Nurasyid M, Orini M, Padmanabhan S, Radmanesh F and Ramirez J (2018). Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6. Springer Nature  Genome Biology  vol. 19, (1)  

Hosford PS, Christie IN, Niranjan A, Aziz Q, Anderson N, Ang R, Lythgoe MF, Wells JA, Tinker A and Gourine AV (2018). A critical role for the ATP-sensitive potassium channel subunit KIR6.1 in the control of cerebral blood flow. SAGE Publications  Journal of Cerebral Blood Flow and Metabolism   

Ramírez J, Duijvenboden SV, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A, Lambiase PD and Munroe PB (2018). Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system. Springer Nature  Nature Communications  vol. 9, (1)  

Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M, Harmer SC, Tinker A, Smith JGW, Carrier L, Williams PM, Gaffney D, Eschenhagen T, Hansen A and Denning C (2018). CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy. Oxford University Press (OUP)  European Heart Journal  vol. 39, (43) 3879-3892.  

Aziz Q, Finlay M, Montaigne D, Ojake L, Li Y, Anderson N, Ludwig A and Tinker A (2018). ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia. Elsevier  Journal of Biological Chemistry  vol. 293, (23) 8912-8921.  

Arcidiacono P, Webb CM, Brooke MA, Zhou H, Delaney PJ, Ng K-E, Blaydon DC, Tinker A, Kelsell DP and Chikh A (2018). p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response. Springer Nature  Nature Communications  vol. 9, (1)  

Tinker A, Finlay M, Nobles M and Opel A (2018). Erratum to “The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation” [Pharmacol. Res. 105 (2016) 54–61]. Elsevier  Pharmacological Research  vol. 129,  

Rathod VS, Harmer SC, Salsbury GA, Bitner-Glindzicz M, Lambiase PD and Tinker A (2018). P449The novel long QT syndrome type 1 mutation KCNQ1-p.Thr247dup causes severe channel dysfunction but retains preserved adrenergic regulation. Oxford University Press (OUP)  EP Europace  vol. 20, (suppl_1) i87-i87.  

Lovering RC, Roncaglia P, Howe DG, Laulederkind SJF, Khodiyar VK, Berardini TZ, Tweedie S, Foulger RE, Osumi-Sutherland D, Campbell NH, Huntley RP, Talmud PJ, Blake JA, Breckenridge R, Riley PR, Lambiase PD, Elliott PM, Clapp L, Tinker A and Hill DP (2018). Improving Interpretation of Cardiac Phenotypes and Enhancing Discovery With Expanded Knowledge in the Gene Ontology. Circ Genom Precis Med  vol. 11, (2) e001813-e001813.  

Nobles M, Montaigne D, Sebastian S, Birnbaumer L and Tinker A (2018). Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K+ currents in adult murine atria. American Physiological Society  American Journal of Physiology - Cell Physiology  vol. 314, (5) c616-c626.  

Aziz Q, Li Y and Tinker A (2018). Endothelial biology and ATP-sensitive potassium channels. Taylor & Francis  Channels  vol. 12, (1) 45-46.  

Aziz Q, Li Y and Tinker A (2018). Potassium channels in the sinoatrial node and their role in heart rate control. Taylor & Francis  Channels  vol. 12, (1) 356-366.  

Munroe PB, Addison S, Abrams DJ, Sebire NJ, Cartwright J, Donaldson I, Cohen MM, Mein C, Tinker A, Harmer SC, Aziz Q, Terry A, Struebig M, Warren HR, Vadgama B, Fowler DJ, Peebles D, Taylor AM, Lally PJ and Thayyil S (2018). Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths. Wolters Kluwer  Circulation Genomic and Precision Medicine  vol. 11, (1)  

Orini M, Tinker A, Munroe PB and Lambiase PD (2018). Correction: Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort. PLoS One  vol. 13, (2) e0193039-e0193039.  

Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR, Dunkel L, Lambiase PD and Tinker A (2017). Ajmaline blocks I Na and I Kr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters. Elsevier  Stem Cell Research  vol. 25, 233-244.  

TINKER A and Lane J D (2017). Have the Findings from Clinical Risk Prediction and Trials Any Key Messages for Safety Pharmacology? Frontiers Media  Frontiers in Physiology  vol. 8,  

Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG and Tarasova YS (2017). Mammalian γ2 AMPK regulates intrinsic heart rate. Macmillan Publications  Nat Commun  vol. 8, (1) 1258-1258.  

Royal AA, Tinker A and Harmer SC (2017). Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking. Public Library of Science  PLoS One  vol. 12, (10) e0186293-e0186293.  

Lane JD, Montaigne D and Tinker A (2017). Tissue-Level Cardiac Electrophysiology Studied in Murine Myocardium Using a Microelectrode Array: Autonomic and Thermal Modulation. Springer Nature  The Journal of Membrane Biology  vol. 250, (5) 471-481.  

Aziz Q, Li Y, Anderson N, Ojake L, Tsisanova E and Tinker A (2017). Molecular and functional characterization of the endothelial ATP-sensitive potassium channel. Elsevier  Journal of Biological Chemistry  vol. 292, (43) 17587-17597.  

Orini M, Tinker A, Munroe PB and Lambiase PD (2017). Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort. Public Library of Science  PLoS One  vol. 12, (9) e0183732-e0183732.  

Tinker A (2017). The mechanisms of ventricular arrhythmia in Chagas disease. Elsevier  International Journal of Cardiology  vol. 240, 372-373.  

Munroe PB and Tinker A (2017). Heritability of resting heart rate and association with mortality in middle-aged and elderly twins. Heart  vol. 104, (1) 6-7.  

Zhang Y, Marrion N, Harmer S, Mohamed R, Tinker A and Hancox J (2017). 227hERG potassium channel modulation by P127T KCNE1. Oxford University Press (OUP)  EP Europace  vol. 19, (suppl_3) iii22-iii22.  

MUNROE PB, Caulfield M, Stirrups K, van den Berg M, Warren H and Cabrera CP (2017). Discovery of novel heart rate-associated loci using the exome chip. Oxford University Press (OUP)  Human Molecular Genetics   

Poliandri A, Miller D, Howard S, Nobles M, Ruiz-Babot G, Harmer S, Tinker A, McKay T, Guasti L and Dunkel L (2017). Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells. Elsevier  Molecular and Cellular Endocrinology  vol. 447, 12-22.  

Finlay M, Harmer SC and Tinker A (2017). The control of cardiac ventricular excitability by autonomic pathways. Elsevier  Pharmacology & Therapeutics  vol. 174, 97-111.  

Mellor G, Orini M, Specterman MJ, Sawhney VS, Merghani A, Claridge S, Laksman Z, Gerull B, Simpson C, Klein G, Champagne J, Talajic M, Gardner M, Steinberg C, Janzen M, Arbour L, Green M, Angaran P, Roberts J, Leather R, Sanatani S, Chauhan V, Healey J, Krahn A, Taggart P, Srinivasan N, Hayward M, Lambiase PD, Aziz Q and Finlay MC (2016). YOUNG INVESTIGATORS COMPETITION. Oxford University Press (OUP)  EP Europace  vol. 18, (suppl_2) ii1-ii3.  

Champney F, Maddock LJ, Welford J, Kemp J, Allan V, Persidskikh Y, Orini M, Ang R, Workman AJ, Wong L, Honarbakhsh S, Leong KMW, Silberbauer J, O'Nunain S, Gomes J, McCready J, Bostock J, Shaw K, McKenna C, Bailey J, Honarbakhsh S, Casas JP, Wallace J, Hunter R, Schilling R, Perel P, Morley K, Banerjee A, Hemingway H and Mrochak A (2016). ORAL ABSTRACTS (1). Oxford University Press (OUP)  EP Europace  vol. 18, (suppl_2) ii4-ii7.  

MUNROE PB (2016). Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension. Nature Publishing Group  Nature Genetics   

Ang R, Abramowitz J, Birnbaumer L, Gourine AV and Tinker A (2016). The role of GαO‐mediated signaling in the rostral ventrolateral medulla oblongata in cardiovascular reflexes and control of cardiac ventricular excitability. Wiley  Physiological Reports  vol. 4, (15)  

Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P, Miller D, Harmer S, Poliandri A, Kogaki S, Sakata Y, Dunkel L, Tinker A, Hadjantonakis A-K, Sawa Y, Sasaki H, Ozono K, Suzuki K and Yashiro K (2016). GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway. Cell Rep  vol. 16, (4) 1026-1038.  

Zhou X, Harmer S, Bueno-Orovio A, Burrage K, Tinker A and Rodriguez B (2016). 57-03: How Can a Gain-of-Function Mutation in KCNQ1 Lead to Action Potential Prolongation? Oxford University Press (OUP)  EP Europace  vol. 18, (suppl_1) i167-i167.  

Harmer SC and Tinker A (2016). The impact of recent advances in genetics in understanding disease mechanisms underlying the long QT syndromes. De Gruyter  Biol Chem  vol. 397, (7) 679-693.  

Tinker A, Finlay M, Nobles M and Opel A (2016). The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation. Elsevier  Pharmacological Research  vol. 105, 54-61.  

Richards DA, Fletcher SA, Nobles M, Kossen H, Tedaldi L, Chudasama V, Tinker A and Baker JR (2016). Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines. Royal Society of Chemistry (RSC)  Organic & Biomolecular Chemistry  vol. 14, (2) 455-459.  

Rodriguez B, Carusi A, Abi-Gerges N, Ariga R, Britton O, Bub G, Bueno-Orovio A, Burton RAB, Carapella V, Cardone-Noott L, Daniels MJ, Davies MR, Dutta S, Ghetti A, Grau V, Harmer S, Kopljar I, Lambiase P, Lu HR, Lyon A, Minchole A, Muszkiewicz A, Oster J, Paci M, Passini E, Severi S, Taggart P, Tinker A, Valentin J-P and Varro A (2015). Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop. Oxford University Press (OUP)  EP Europace  vol. 18, (9) 1287-1298.  

Munroe PB and Tinker A (2015). Genome-wide association studies and contribution to cardiovascular physiology. American Physiological Society  Physiological Genomics  vol. 47, (9) 365-375.  

Nessa A, Aziz QH, Thomas AM, Harmer SC, Tinker A and Hussain K (2015). Molecular mechanisms of congenital hyperinsulinism due to autosomal dominant mutations in ABCC8. Oxford University Press (OUP)  Human Molecular Genetics  vol. 24, (18) 5142-5153.  

Opel A, Nobles M, Montaigne D, Finlay M, Anderson N, Breckenridge R and Tinker A (2015). Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling*. Elsevier  Journal of Biological Chemistry  vol. 290, (31) 19233-19244.  

Machhada A, Ang R, Ackland GL, Ninkina N, Buchman VL, Lythgoe MF, Trapp S, Tinker A, Marina N and Gourine AV (2015). Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve. Elsevier  Heart Rhythm  vol. 12, (11) 2285-2293.  

Notari M, Hu Y, Sutendra G, Dedeić Z, Lu M, Dupays L, Yavari A, Carr CA, Zhong S, Opel A, Tinker A, Clarke K, Watkins H, Ferguson DJP, Kelsell DP, de Noronha S, Sheppard MN, Hollinshead M, Mohun TJ and Lu X (2015). iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death. Proceedings of the National Academy of Sciences  Proceedings of the National Academy of Sciences of the United States of America  vol. 112, (9) e973-e981.  

Aziz Q, Li Y and Tinker A (2015). ATP-sensitive potassium channels and vascular function. Taylor & Francis  Channels  vol. 9, (1) 3-4.  

Fletcher SA, Sin PKB, Nobles M, Årstad E, Tinker A and Baker JR (2015). A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging. Royal Society of Chemistry (RSC)  Organic & Biomolecular Chemistry  vol. 13, (37) 9559-9563.  

Arya VB, Aziz Q, Nessa A, Tinker A and Hussain K (2014). Congenital hyperinsulinism: clinical and molecular characterisation of compound heterozygous ABCC8 mutation responsive to Diazoxide therapy. Springer Nature  International Journal of Pediatric Endocrinology  vol. 2014, (1)  

Lambiase PD and Tinker A (2014). Connexins in the heart. Springer Nature  Cell and Tissue Research  vol. 360, (3) 675-684.  

Lane JD, Abramowitz J, Birnbaumer L and Tinker A (2014). 51Cardiac specific knockout of G-alpha-i2 in a murine model of heart failure. Europace  vol. 16 Suppl 3,  

Aziz Q, Thomas AM, Gomes J, Ang R, Sones WR, Li Y, Ng K-E, Gee L and Tinker A (2014). The ATP-sensitive potassium channel subunit, Kir6.1, in vascular smooth muscle plays a major role in blood pressure control. Hypertension  vol. 64, (3) 523-529.  

Harmer SC, Mohal JS, Royal AA, McKenna WJ, Lambiase PD and Tinker A (2014). Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1. Biochem J  vol. 462, (1) 133-142.  

Tinker A, Aziz Q and Thomas A (2014). The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system. Br J Pharmacol  vol. 171, (1) 12-23.  

Youziel J, Akhbar AR, Aziz Q, Smith MEB, Caddick S, Tinker A and Baker JR (2014). Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents. ORGANIC & BIOMOLECULAR CHEMISTRY  vol. 12, (4) 557-560.  

Tinker A and Harmer SC (2013). Potassium channels regulating the electrical activity of the heart. Translational Vascular Medicine: Pathogenesis, Diagnosis, and Treatment  

Sebastian S, Ang R, Abramowitz J, Weinstein LS, Chen M, Ludwig A, Birnbaumer L and Tinker A (2013). The in vivo regulation of heart rate in the murine sinoatrial node by stimulatory and inhibitory heterotrimeric G proteins. Am J Physiol Regul Integr Comp Physiol  vol. 305, (4) R435-R442.  

Ang R, Birnbaumer L, Gourine AV and Tinker A (2013). The role of GalphaO-mediated signalling in the central nervous mechanisms controlling sympathetic outflow to the heart. Oxford University Press (OUP)  European Heart Journal  vol. 34, (suppl_1)  

Schwarzer S, Mashanov GI, Molloy JE and Tinker A (2013). Using total internal reflection fluorescence microscopy to observe ion channel trafficking and assembly. Methods Mol Biol  vol. 998, 201-208.  

Telezhkin V, Thomas AM, Harmer SC, Tinker A and Brown DA (2013). A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P₂. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY  vol. 465, (7) 945-953.  

Posokhova E, Ng D, Opel A, Masuho I, Tinker A, Biesecker LG, Wickman K and Martemyanov KA (2013). Essential Role of the m₂R-RGS6-I_KACh Pathway in Controlling Intrinsic Heart Rate Variability. PLOS ONE  vol. 8, (10)  

Risebro CA, Petchey LK, Smart N, Gomes J, Clark J, Vieira JM, Yanni J, Dobrzynski H, Davidson S, Zuberi Z, Tinker A, Shui B, Tallini YI, Kotlikoff MI, Miquerol L, Schwartz RJ and Riley PR (2012). Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3. Circ Res  vol. 111, (2) e19-e31.  

Harmer SC, Mohal JS, Kemp D and Tinker A (2012). Readthrough of long-QT syndrome type 1 nonsense mutations rescues function but alters the biophysical properties of the channel. Biochem J  vol. 443, (3) 635-642.  

Tinker A (2012). The assembly and targeting of potassium channels. Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels  

Aziz Q, Thomas AM, Khambra T and Tinker A (2012). Regulation of the ATP-sensitive potassium channel subunit, Kir6.2, by a Ca2+-dependent protein kinase C. J Biol Chem  vol. 287, (9) 6196-6207.  

Telezhkin V, Reilly JM, Thomas AM, Tinker A and Brown DA (2012). Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding. JOURNAL OF BIOLOGICAL CHEMISTRY  vol. 287, (13) 10001-10012.  

Maden CH, Gomes J, Schwarz Q, Davidson K, Tinker A and Ruhrberg C (2012). NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system. DEVELOPMENTAL BIOLOGY  vol. 369, (2) 277-285.  

Gomes J, Finlay M, Ahmed AK, Ciaccio EJ, Asimaki A, Saffitz JE, Quarta G, Nobles M, Syrris P, Chaubey S, McKenna WJ, TINKER A and Lambiase PD (2012). Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study. Oxford University Press  Eur Heart Journal  vol. 33, (15) 1942-1953.  

Ang R, Opel A and Tinker A (2012). The Role of Inhibitory G Proteins and Regulators of G Protein Signaling in the in vivo Control of Heart Rate and Predisposition to Cardiac Arrhythmias. Frontiers  Frontiers in Physiology  vol. 3,  

Tinker A and Harmer SC (2011). Potassium Channels Regulating the Electrical Activity of the Heart. Translational Vascular Medicine  Springer Nature   

Hothersall JD, Black J, Caddick S, Vinter JG, Tinker A and Baker JR (2011). The design, synthesis and pharmacological characterization of novel β2‐adrenoceptor antagonists. Wiley  British Journal of Pharmacology  vol. 164, (2) 317-331.  

Schumacher FF, Nobles M, Ryan CP, Smith MEB, Tinker A, Caddick S and Baker JR (2011). In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation. American Chemical Society (ACS)  Bioconjugate Chemistry  vol. 22, (2) 132-136.  

Voitychuk OI, Strutynskyi RB, Yagupolskii LM, Tinker A, Moibenko OO and Shuba YM (2011). Sarcolemmal cardiac KATP channels as a target for the cardioprotective effects of the fluorine‐containing pinacidil analogue, flocalin. Wiley  British Journal of Pharmacology  vol. 162, (3) 701-711.  

Thomas AM, Harmer SC, Khambra T and Tinker A (2011). Characterization of a binding site for anionic phospholipids on KCNQ1. Journal of Biological Chemistry  vol. 286, 2088-2100.  

Kapoor RR, Flanagan SE, James CT, McKiernan J, Thomas AM, Harmer SC, Shield JP, Tinker A, Ellard S and Hussain K (2011). Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant ABCC8/KCNJ11 mutations. Diab tologia  vol. 54, 2575-2583.  

Bollini S, Pozzobon M, Nobles M, Riegler J, Dong X, Piccoli M, Chiavegato A, Price AN, Ghionzoli M, Cheung KK, Cabrelle A, O’Mahoney PR, Cozzi E, Sartore S, Tinker A, Lythgoe MF and De Coppi P (2010). In Vitro and In Vivo Cardiomyogenic Differentiation of Amniotic Fluid Stem Cells. Springer Nature  Stem Cell Reviews and Reports  vol. 7, (2) 364-380.  

Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M and Segal AW (2010). Retraction Note: The large-conductance Ca2+-activated K+ channel is essential for innate immunity. Springer Nature  Nature  vol. 468, (7320) 122-122.  

Baker JR, Hothersall JD, Fitzmaurice RJ, Tucknott M, Vinter A, Tinker A and Caddick S (2010). ChemInform Abstract: An Efficient Asymmetric Synthesis of the Potent β‐Blocker ICI‐118,551 Allows the Determination of Enantiomer Dependency on Biological Activity. Wiley  ChemInform  vol. 41, (43) no-no.  

Schwarzer S, Nobles M and Tinker A (2010). Do Caveolae Have a Role in the Fidelity and Dynamics of Receptor Activation of G-protein-gated Inwardly Rectifying Potassium Channels?*. Elsevier  Journal of Biological Chemistry  vol. 285, (36) 27817-27826.  

Zuberi Z, Nobles M, Sebastian S, Dyson A, Lim SY, Breckenridge R, Birnbaumer L and Tinker A (2010). Absence of the Inhibitory G-Protein G&agr;i2 Predisposes to Ventricular Cardiac Arrhythmia. Wolters Kluwer  Circulation Arrhythmia and Electrophysiology  vol. 3, (4) 391-400.  

Ng K-E, Schwarzer S, Duchen MR and Tinker A (2010). The Intracellular Localization and Function of the ATP-Sensitive K+ Channel Subunit Kir6.1. Springer Nature  The Journal of Membrane Biology  vol. 234, (2) 137-147.  

Nobles M, Sebastian S and Tinker A (2010). HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes. Springer Nature  Pflügers Archiv - European Journal of Physiology  vol. 460, (1) 99-108.  

Aziz Q, Thomas A, Khambra T and Tinker A (2010). Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channel. Elsevier  European Journal of Pharmacology  vol. 634, (1-3) 26-32.  

Mashanov GI, Nobles M, Harmer SC, Molloy JE and Tinker A (2010). Direct observation of individual KCNQ1 potassium channels reveals their distinctive diffusive behavior. Journal of Biological Chemistry  vol. 285, 3664-3675.  

Tinker A and Harmer SC (2010). K+ channels in the heart: new insights and therapeutic implications. Expert Rev Clin Pharmacol  vol. 3, 305-319.  

Harmer SC, Wilson AJ, Aldridge R and Tinker A (2010). Mechanisms of disease pathogenesis in long QT syndrome type 5. Am J Physiol Cell Physiol  vol. 298, C263-C273.  

Baker JR, Hothersall JD, Fitzmaurice RJ, Tucknott M, Vinter A, Tinker A and Caddick S (2010). An efficient asymmetric synthesis of the potent β-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity. Royal Society of Chemistry (RSC)  Chemical Communications  vol. 46, (22) 3953-3954.  

Orie N, Thomas A, Perrino B, Tinker A and Clapp L (2009). Ca2+/calcineurin regulation of cloned vascular KATP channels: crosstalk with the protein kinase A pathway. Wiley  British Journal of Pharmacology  vol. 157, (4) 554-564.  

Breckenridge RA, Zuberi Z, Gomes J, Orford R, Dupays L, Felkin LE, Clark JE, Magee AI, Ehler E, Birks EJ, Barton PJR, Tinker A and Mohun TJ (2009). Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice. Elsevier  Journal of Molecular and Cellular Cardiology  vol. 47, (1) 133-141.  

Zuberi Z, Birnbaumer L and Tinker A (2008). The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics. American Physiological Society  AJP Regulatory Integrative and Comparative Physiology  vol. 295, (6) r1822-r1830.  

Campanella M, Tan C, Abramov A, Tinker A and Duchen M (2008). S12/4 Mitochondria as ATP consumers: the cell biology of the endogenous inhibitory protein, IF1. Elsevier  Biochimica et Biophysica Acta (BBA) - Bioenergetics  vol. 1777,  

Quinn KV, Behe P and Tinker A (2008). Monitoring changes in membrane phosphatidylinositol 4,5‐bisphosphate in living cells using a domain from the transcription factor tubby. Wiley  The Journal of Physiology  vol. 586, (12) 2855-2871.  

Farzaneh T and Tinker A (2008). Differences in the mechanism of metabolic regulation of ATP-sensitive K+ channels containing Kir6.1 and Kir6.2 subunits. Oxford University Press (OUP)  Cardiovascular Research  vol. 79, (4) 621-631.  

Breckenridge RA, Zuberi Z, Felkin L, Birks E, Barton P, Tinker A and Mohun T (2008). 446 Overexpression of the transcription factor Hand1 causes sudden cardiac death in mice. Oxford University Press (OUP)  European Journal of Heart Failure Supplements  vol. 7, 109-109.  

Campanella M, Casswell E, Chong S, Farah Z, Wieckowski MR, Abramov AR, TINKER A and Duchen MR (2008). Regulation of mitochondrial structure and function by IF1, the endogenous inhibitor of the mitochondrial ATPase. Cell Metabolism  vol. 8, (1) 13-25.  

Thomas AM and Tinker A (2008). Determination of Phosphoinositide Binding to K+ Channel Subunits Using a Protein—Lipid Overlay Assay. Springer Nature  Methods in Molecular Biology  vol. 491, 103-111.  

Falcetti E, Flavell DM, Staels B, Tinker A, Haworth SG and Clapp LH (2007). IP receptor-dependent activation of PPARγ by stable prostacyclin analogues. Elsevier  Biochemical and Biophysical Research Communications  vol. 360, (4) 821-827.  

Muzyamba M, Farzaneh T, Behe P, Thomas A, Christesen HBT, Brusgaard K, Hussain K and Tinker A (2007). Complex ABCC8 DNA variations in congenital hyperinsulinism: lessons from functional studies. Wiley  Clinical Endocrinology  vol. 67, (1) 115-124.  

Hughes S, Marsh SJ, Tinker A and Brown DA (2007). PIP2-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: direct on-line assessment of PIP2 depletion by Gq-coupled receptors in single living neurons. Springer Nature  Pflügers Archiv - European Journal of Physiology  vol. 455, (1) 115-124.  

Harmer SC and Tinker A (2007). The role of abnormal trafficking of KCNE1 in long QT syndrome 5. Biochemical Society Transactions  vol. 35, 1074-1076.  

Tennant BP, Cui Y, Tinker A and Clapp LH (2006). Functional Expression of Inward Rectifier Potassium Channels in Cultured Human Pulmonary Smooth Muscle Cells: Evidence for a Major Role of Kir2.4 Subunits. Springer Nature  The Journal of Membrane Biology  vol. 213, (1) 19-29.  

Kang Y, Ng B, Leung Y-M, He Y, Xie H, Lodwick D, Norman RI, Tinker A, Tsushima RG and Gaisano HY (2006). Syntaxin-1A Actions on Sulfonylurea Receptor 2A Can Block Acidic pH-induced Cardiac KATP Channel Activation*. Elsevier  Journal of Biological Chemistry  vol. 281, (28) 19019-19028.  

Thomas AM, Brown SG, Leaney JL and Tinker A (2006). Differential Phosphoinositide Binding to Components of the G Protein-Gated K+ Channel. Springer Nature  The Journal of Membrane Biology  vol. 211, (1) 43-53.  

Tinker A (2006). The selective interactions and functions of regulators of G-protein signalling. Elsevier  Seminars in Cell and Developmental Biology  vol. 17, (3) 377-382.  

Nobles M, Benians A and Tinker A (2005). Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells. Proceedings of the National Academy of Sciences  Proceedings of the National Academy of Sciences of the United States of America  vol. 102, (51) 18706-18711.  

Wilson AJ, Quinn KV, Graves FM, Bitner-Glindzicz M and Tinker A (2005). Abnormal KCNQ1 trafficking influences disease pathogenesis in hereditary long QT syndromes (LQT1). Oxford University Press (OUP)  Cardiovascular Research  vol. 67, (3) 476-486.  

Brown SG, Thomas A, Dekker LV, Tinker A and Leaney JL (2005). PKC-δ sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells. American Physiological Society  American Journal of Physiology - Cell Physiology  vol. 289, (3) c543-c556.  

Benians A, Nobles M, Hosny S and Tinker A (2005). Regulators of G-protein Signaling Form a Quaternary Complex with the Agonist, Receptor, and G-protein A NOVEL EXPLANATION FOR THE ACCELERATION OF SIGNALING ACTIVATION KINETICS*. Elsevier  Journal of Biological Chemistry  vol. 280, (14) 13383-13394.  

Morrissey A, Rosner E, Lanning J, Parachuru L, Dhar Chowdhury P, Han S, Lopez G, Tong X, Yoshida H, Nakamura TY, Artman M, Giblin JP, Tinker A and Coetzee WA (2005). Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. Springer Nature  BMC Physiology  vol. 5, (1)  

Quinn KV, Giblin JP and Tinker A (2004). Multisite Phosphorylation Mechanism for Protein Kinase A Activation of the Smooth Muscle ATP-Sensitive K+ Channel. Wolters Kluwer  Circulation Research  vol. 94, (10) 1359-1366.  

Leaney JL, Benians A, Brown S, Nobles M, Kelly D and Tinker A (2004). Rapid desensitization of G protein-gated inwardly rectifying K+ currents is determined by G protein cycle. American Physiological Society  American Journal of Physiology - Cell Physiology  vol. 287, (1) c182-c191.  

Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M and Segal AW (2004). The large-conductance Ca2+-activated K+ channel is essential for innate immunity. Springer Nature  Nature  vol. 427, (6977) 853-858.  

Quinn KV, Cui Y, Giblin JP, Clapp LH and Tinker A (2003). Do Anionic Phospholipids Serve as Cofactors or Second Messengers for the Regulation of Activity of Cloned ATP-Sensitive K+ Channels? Wolters Kluwer  Circulation Research  vol. 93, (7) 646-655.  

Cui Y, Tinker A and Clapp LH (2003). Different molecular sites of action for the KATP channel inhibitors, PNU‐99963 and PNU‐37883A. Wiley  British Journal of Pharmacology  vol. 139, (1) 122-128.  

Benians A, Leaney JL and Tinker A (2003). Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K+ channels. Proceedings of the National Academy of Sciences  Proceedings of the National Academy of Sciences of the United States of America  vol. 100, (10) 6239-6244.  

Benians A, Leaney JL, Milligan G and Tinker A (2003). The Dynamics of Formation and Action of the Ternary Complex Revealed in Living Cells Using a G-protein-gated K+ Channel as a Biosensor*. Elsevier  Journal of Biological Chemistry  vol. 278, (12) 10851-10858.  

Giblin JP, Quinn K and Tinker A (2002). The cytoplasmic C‐terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking. Wiley  The FEBS Journal  vol. 269, (21) 5303-5313.  

Lawrence KM, Chanalaris A, Scarabelli T, Hubank M, Pasini E, Townsend PA, Comini L, Ferrari R, Tinker A, Stephanou A, Knight RA and Latchman DS (2002). KATP Channel Gene Expression Is Induced by Urocortin and Mediates Its Cardioprotective Effect. Wolters Kluwer  Circulation  vol. 106, (12) 1556-1562.  

Leaney JL, Benians A, Graves FM and Tinker A (2002). A Novel Strategy to Engineer Functional Fluorescent Inhibitory G-protein α Subunits*. Elsevier  Journal of Biological Chemistry  vol. 277, (32) 28803-28809.  

Giblin JP, Cui Y, Clapp LH and Tinker A (2002). Assembly Limits the Pharmacological Complexity of ATP-sensitive Potassium Channels*. Elsevier  Journal of Biological Chemistry  vol. 277, (16) 13717-13723.  

Clapp LH, Finney P, Turcato S, Tran S, Rubin LJ and Tinker A (2002). Differential Effects of Stable Prostacyclin Analogs on Smooth Muscle Proliferation and Cyclic AMP Generation in Human Pulmonary Artery. American Thoracic Society  American Journal of Respiratory Cell and Molecular Biology  vol. 26, (2) 194-201.  

Cui Y, Tran S, Tinker A and Clapp LH (2002). The Molecular Composition of KATP Channels in Human Pulmonary Artery Smooth Muscle Cells and Their Modulation by Growth. American Thoracic Society  American Journal of Respiratory Cell and Molecular Biology  vol. 26, (1) 135-143.  

Huang L, Bitner-Glindzicz M, Tranebjærg L and Tinker A (2001). A spectrum of functional effects for disease causing mutations in the Jervell and Lange-Nielsen syndrome. Oxford University Press (OUP)  Cardiovascular Research  vol. 51, (4) 670-680.  

Leaney JL, Dekker LV and Tinker A (2001). Regulation of a G protein‐gated inwardly rectifying K+ channel by a Ca2+‐independent protein kinase C. Wiley  The Journal of Physiology  vol. 534, (2) 367-379.  

Cui Y, Giblin JP, Clapp LH and Tinker A (2001). A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits. Proceedings of the National Academy of Sciences  Proceedings of the National Academy of Sciences of the United States of America  vol. 98, (2) 729-734.  

Graves FM and Tinker A (2000). Functional Expression of the Pore Forming Subunit of the ATP-Sensitive Potassium Channel in Saccharomyces cerevisiae. Elsevier  Biochemical and Biophysical Research Communications  vol. 272, (2) 403-409.  

Leaney JL and Tinker A (2000). The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel. Proceedings of the National Academy of Sciences  Proceedings of the National Academy of Sciences of the United States of America  vol. 97, (10) 5651-5656.  

Leaney JL, Milligan G and Tinker A (2000). The G Protein α Subunit Has a Key Role in Determining the Specificity of Coupling to, but Not the Activation of, G Protein-gated Inwardly Rectifying K+ Channels*. Elsevier  Journal of Biological Chemistry  vol. 275, (2) 921-929.  

Giblin JP, Leaney JL and Tinker A (1999). The Molecular Assembly of ATP-sensitive Potassium Channels DETERMINANTS ON THE PORE FORMING SUBUNIT*. Elsevier  Journal of Biological Chemistry  vol. 274, (32) 22652-22659.  

Tinker A and Jan LY (1999). Chapter 9 The Assembly of Inwardly Rectifying Potassium Channels. Elsevier  Current Topics in Membranes  vol. 46, 143-158.  

Lucie H and Tinker A (1998). Potassium channels in the vasculature. Wolters Kluwer  Current Opinion in Nephrology & Hypertension  vol. 7, (1) 83-98.  

Welch W, Williams AJ, Tinker A, Mitchell KE, Deslongchamps P, Lamothe J, Gerzon K, Bidasee KR, Besch HR, Airey JA, Sutko JL and Ruest L (1997). Structural Components of Ryanodine Responsible for Modulation of Sarcoplasmic Reticulum Calcium Channel Function †. American Chemical Society (ACS)  Biochemistry  vol. 36, (10) 2939-2950.  

Tinker A, Jan YN and Jan LY (1996). Regions Responsible for the Assembly of Inwardly Rectifying Potassium Channels. Elsevier  Cell  vol. 87, (5) 857-868.  

Tinker A, Sutko JL, Ruest L, Deslongchamps P, Welch W, Airey JA, Gerzon K, Bidasee KR, Besch HR and Williams AJ (1996). Electrophysiological effects of ryanodine derivatives on the sheep cardiac sarcoplasmic reticulum calcium-release channel. Elsevier  Biophysical Journal  vol. 70, (5) 2110-2119.  

Tinker A and Williams AJ (1995). Measuring the length of the pore of the sheep cardiac sarcoplasmic reticulum calcium-release channel using related trimethylammonium ions as molecular calipers. Elsevier  Biophysical Journal  vol. 68, (1) 111-120.  

Lindsay AR, Tinker A and Williams AJ (1994). How does ryanodine modify ion handling in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel? Rockefeller University Press  The Journal of General Physiology  vol. 104, (3) 425-447.  

Tinker A and Williams AJ (1993). Probing the structure of the conduction pathway of the sheep cardiac sarcoplasmic reticulum calcium-release channel with permeant and impermeant organic cations. Rockefeller University Press  The Journal of General Physiology  vol. 102, (6) 1107-1129.  

Tinker A and Williams AJ (1993). Using large organic cations to probe the nature of ryanodine modification in the sheep cardiac sarcoplasmic reticulum calcium release channel. Elsevier  Biophysical Journal  vol. 65, (4) 1678-1683.  

Tinker A, Lindsay ARG and Williams AJ (1993). Cation conduction in the calcium release channel of the cardiac sarcoplasmic reticulum under physiological and pathophysiological conditions. Oxford University Press (OUP)  Cardiovascular Research  vol. 27, (10) 1820-1825.  

Tinker A and Williams AJ (1993). Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel. Elsevier  Biophysical Journal  vol. 65, (2) 852-864.  

Tinker A and Williams AJ (1992). Divalent cation conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum. Rockefeller University Press  The Journal of General Physiology  vol. 100, (3) 479-493.  

Tinker A, Lindsay AR and Williams AJ (1992). A model for ionic conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum. Rockefeller University Press  The Journal of General Physiology  vol. 100, (3) 495-517.  

Tinker A, Lindsay AR and Williams AJ (1992). Large tetraalkyl ammonium cations produce a reduced conductance state in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel. Elsevier  Biophysical Journal  vol. 61, (5) 1122-1132.  

Tinker A, Lindsay ARG and Williams AJ (1992). Block of the sheep cardiac sarcoplasmic reticulum Ca2+-release channel by tetra-alkyl ammonium cations. Springer Nature  The Journal of Membrane Biology  vol. 127, (2) 149-159.