Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation
Dembitz V, Lawson H, Burt R, Natani S, Philippe C, James SC, Atkinson S, Durko J, Wang LM, Campos J, Magee AMS, Woodley K, Austin MJ, Rio-Machin A, Casado P, Bewicke-Copley F, Rodriguez Blanco G, Pereira-Martins D, Oudejans L, Boet E, von Kriegsheim A, Schwaller J, Finch AJ, Patel B, Sarry J-E, Tamburini J, Schuringa JJ, Hazlehurst L, Copland III JA and Yuneva M
Leukemia, Springer Nature vol. 38 (11), 2395-2409.  
26-08-2024

CREBBP histone acetyltransferase domain mutations predict response to mTOR inhibition in relapsed/refractory follicular lymphoma
Kumar EA, Korfi K, Bewicke‐Copley F, Close K, Heward J, Witzig T, Leukam M, Ansell S, Scott J, Clear A, Efeyan A, Green M, Siebert R, Peck B, Calaminici M, Wang J, Smith S, Novak A, Fitzgibbon J and Okosun J
British Journal of Haematology, Wiley vol. 205 (5), 1804-1809.  
26-08-2024

Abstract B020: SF3B1  hotspot mutations confer sensitivity to PARP inhibition through a defective replication stress response
Bland P, Saville H, Wai PT, Curnow L, Nieminuszczy J, Ravindran N, Barker HE, Wright J, Yu L, Mavrommati I, Peck B, Gazinska P, Pemberton HN, Gulati A, Guppy N, Roxanis I, Pratt G, Oldreive C, Stankovic T, Barlow S, Kalirai H, Coupland SE, Broderick R, Alsafadi S, Houy A, Stern M-H, Pettit S, Choudhary JS, Haider S and Niedzwiedz W
Molecular Cancer Therapeutics, American Association For Cancer Research (Aacr) vol. 22 (12_Supplement), b020-b020.  
01-12-2023

SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response
Bland P, Saville H, Wai PT, Curnow L, Muirhead G, Nieminuszczy J, Ravindran N, John MB, Hedayat S, Barker HE, Wright J, Yu L, Mavrommati I, Read A, Peck B, Allen M, Gazinska P, Pemberton HN, Gulati A, Nash S, Noor F, Guppy N, Roxanis I, Pratt G, Oldreive C, Stankovic T, Barlow S, Kalirai H, Coupland SE and Broderick R
Nature Genetics, Springer Nature vol. 55 (8), 1311-1323.  
31-07-2023

Abstract P6-10-05: Mutations in the RNA Splicing Factor SF3B1 drive endocrine therapy resistance and confer a targetable replication stress response defect through PARP inhibition
Bland P, Saville H, Read A, Wai P, Muirhead G, Curnow L, Nieminuszczy J, Ravindran N, John M, Hedayat S, Barker H, Wright J, Yu L, Mavrommati I, Peck B, Allen M, Gazinska P, Pemberton H, Gulati A, Nash S, Noor F, Guppy N, Roxanis I, Barlow S, Kalirai H, Coupland S, Broderick R, Alsafadi S, Houy A and Stern M-H
Cancer Research, American Association For Cancer Research (Aacr) vol. 83 (5_Supplement) 
01-03-2023

Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence
Heydt Q, Xintaropoulou C, Clear A, Austin M, Pislariu I, Miraki-Moud F, Cutillas P, Korfi K, Calaminici M, Cawthorn W, Suchacki K, Nagano A, Gribben JG, Smith M, Cavenagh JD, Oakervee H, Castleton A, Taussig D, Peck B, Wilczynska A, McNaughton L, Bonnet D, Mardakheh F and Wrench B
Nature Communications, Nature Research (Part of Springer Nature) 
17-09-2021

3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer
Peck B, Bland P, Mavrommati I, Muirhead G, Cottom H, Wai PT, Maguire SL, Barker HE, Morrison E, Kriplani D, Yu L, Gibson A, Falgari G, Brennan K, Farnie G, Buus R, Marlow R, Novo D, Knight E, Guppy N, Kolarevic D, Susnjar S, Milijic NM, Naidoo K, Gazinska P, Roxanis I, Pancholi S, Martin L-A, Holgersen EM and Cheang MCU
Cancer Research, American Association For Cancer Research (Aacr) vol. 81 (4), 847-859.  
15-02-2021

A micronutrient with major effects on cancer cell viability
Kapara A, Vannini A and Peck B
Nature Metabolism, Nature Research 
06-07-2020

Lipid Metabolism at the Nexus of Diet and Tumor Microenvironment
Peck B and Schulze A
Trends in Cancer, Elsevier vol. 5 (11), 693-703.  
31-10-2019

3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers.
Jones DT, Valli A, Haider S, Zhang Q, Smethurst EA, Schug ZT, Peck B, Aboagye EO, Critchlow SE, Schulze A, Gottlieb E, Wakelam MJO and Harris AL
Molecular Cancer Therapeutics, American Association For Cancer Research vol. 18 (2), 376-388.  
26-11-2018

Abstract 788: Modeling tumor microenvironmental heterogeneity identifies CREBBP as a novel tumor suppressor in breast cancer
Peck B, Bland PJ, Wai PT, Cottom H, Maguire SL, Morrison E, Barker HE, Kriplani D, Marlow R, Naidoo K, Muirhead G, Haider S, Daley F, Wallberg F, Tutt AN and Natrajan RC
Cancer Research, American Association For Cancer Research (Aacr) vol. 78 (13_Supplement), 788-788.  
01-07-2018

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma
Miess H, Dankworth B, Gouw AM, Rosenfeldt M, Schmitz W, Jiang M, Saunders B, Howell M, Downward J, Felsher DW, Peck B and Schulze A
Oncogene, Springer Nature vol. 37 (40), 5435-5450.  
05-06-2018

Abstract NTOC-093: SYNTHETIC LETHAL APPROACHES TO TARGET ARID1A DEFICIENT OVARIAN CANCERS
Khalique S, Williamson CT, Pemberton H, Wai PT, Menon M, Brough R, Leonidou A, Peck B, Banerjee S, Natrajan RC and Lord CJ
Clinical Cancer Research, American Association For Cancer Research (Aacr) vol. 23 (11_Supplement) 
31-05-2017

Identification and Validation of Driver Kinases from Next-Generation Sequencing Data
Leonidou A, Peck B and Natrajan R
Methods in Molecular Biology, Springer Nature vol. 1636, 179-195.  
01-01-2017

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
Morrison E, Wai P, Leonidou A, Bland P, Khalique S, Farnie G, Daley F, Peck B and Natrajan R
Journal of Visualized Experiments, Myjove (118) 
26-12-2016

Three‐dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model
Maguire SL, Peck B, Wai PT, Campbell J, Barker H, Gulati A, Daley F, Vyse S, Huang P, Lord CJ, Farnie G, Brennan K and Natrajan R
The Journal of Pathology, Wiley vol. 240 (3), 315-328.  
19-10-2016

130 Functional assessment of low-frequency mutations in breast cancer
Leonidou A, Maguire SL, Wai PT, Huang P, Peck B and Natrajan RC
European Journal of Cancer, Elsevier vol. 61 
01-07-2016

362 Modelling the tumour microenvironment and employing functional genomics identifies CREBBP as a novel tumour suppressor in triple negative breast cancers
Peck B, Maguire S, Morrison E, Wai P and Natrajan R
European Journal of Cancer, Elsevier vol. 61, s73-s74.  
01-07-2016

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments
Peck B, Schug ZT, Zhang Q, Dankworth B, Jones DT, Smethurst E, Patel R, Mason S, Jiang M, Saunders R, Howell M, Mitter R, Spencer-Dene B, Stamp G, McGarry L, James D, Shanks E, Aboagye EO, Critchlow SE, Leung HY, Harris AL, Wakelam MJO, Gottlieb E and Schulze A
Cancer & Metabolism, Springer Nature vol. 4 (1) 
01-04-2016

Lipid desaturation – the next step in targeting lipogenesis in cancer?
Peck B and Schulze A
The Febs Journal, Wiley vol. 283 (15), 2767-2778.  
11-03-2016

Abstract PR06: Modeling the tumor microenvironment to identify novel loss of function mutations in breast cancer progression
Peck B, Maguire S, Morrison E, Wai P and Natrajan R
Molecular Cancer Research, American Association For Cancer Research (Aacr) vol. 14 (2_Supplement), pr06-pr06.  
01-02-2016

SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme
Lewis CA, Brault C, Peck B, Bensaad K, Griffiths B, Mitter R, Chakravarty P, East P, Dankworth B, Alibhai D, Harris AL and Schulze A
Oncogene, Springer Nature vol. 34 (40), 5128-5140.  
26-01-2015

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress
Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E, Mason S, Blyth K, McGarry L, James D, Shanks E, Kalna G, Saunders RE, Jiang M, Howell M, Lassailly F, Thin MZ, Spencer-Dene B, Stamp G, van den Broek NJF, Mackay G, Bulusu V, Kamphorst JJ, Tardito S, Strachan D, Harris AL, Aboagye EO and Critchlow SE
Cancer Cell, Elsevier vol. 27 (1), 57-71.  
01-01-2015

Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation
Bensaad K, Favaro E, Lewis CA, Peck B, Lord S, Collins JM, Pinnick KE, Wigfield S, Buffa FM, Li J-L, Zhang Q, Wakelam MJO, Karpe F, Schulze A and Harris AL
Cell Reports, Elsevier vol. 9 (1), 349-365.  
25-09-2014

Acetyl-coA synthetase 2 promotes acetate utilization and maintains cell growth under metabolic stress
Schug Z, Peck B, Jones D, Zhang Q, Alam I, Witney T, Smethurst E, Grosskurth S, Harris A, Critchlow S, Aboagye E, Wakelam M, Schulze A and Gottlieb E
Cancer & Metabolism, Springer Nature vol. 2 (Suppl 1) 
01-05-2014

Cholesteryl Esters: Fueling the Fury of Prostate Cancer
Peck B and Schulze A
Cell Metabolism, Elsevier vol. 19 (3), 350-352.  
01-03-2014

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development
Baenke F, Peck B, Miess H and Schulze A
Disease Models & Mechanisms, The Company of Biologists vol. 6 (6), 1353-1363.  
01-11-2013

Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
Griffiths B, Lewis CA, Bensaad K, Ros S, Zhang Q, Ferber EC, Konisti S, Peck B, Miess H, East P, Wakelam M, Harris AL and Schulze A
Cancer & Metabolism, Springer Nature vol. 1 (1) 
23-01-2013

Antagonism between FOXO and MYC Regulates Cellular Powerhouse
Peck B, Ferber EC and Schulze A
Frontiers in Oncology, Frontiers vol. 3 
01-01-2013

FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression
Ferber EC, Peck B, Delpuech O, Bell GP, East P and Schulze A
Cell Death & Differentiation, Springer Nature vol. 19 (6), 968-979.  
02-12-2011

A role for the cancer-associated miR-106b~25 cluster in neuronal stem cells
Peck B and Schulze A
Aging, Impact Journals vol. 3 (4), 329-331.  
31-03-2011

SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2
Peck B, Chen C-Y, Ho K-K, Di Fruscia P, Myatt SS, Coombes RC, Fuchter MJ, Hsiao C-D and Lam EW-F
Molecular Cancer Therapeutics, American Association For Cancer Research (Aacr) vol. 9 (4), 844-855.  
01-04-2010

FOXM1 Confers Acquired Cisplatin Resistance in Breast Cancer Cells
Kwok JM-M, Peck B, Monteiro LJ, Schwenen HDC, Millour J, Coombes RC, Myatt SS and Lam EW-F
Molecular Cancer Research, American Association For Cancer Research (Aacr) vol. 8 (1), 24-34.  
17-01-2010

FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer.
Francis RE, Myatt SS, Krol J, Hartman J, Peck B, McGovern UB, Wang J, Guest SK, Filipovic A, Gojis O, Palmieri C, Peston D, Shousha S, Yu Q, Sicinski P, Coombes RC and Lam EW-F
International Journal of Oncology, Spandidos Publications vol. 35 (1), 57-68.  
04-06-2009

Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer
McGovern UB, Francis RE, Peck B, Guest SK, Wang J, Myatt SS, Krol J, Kwok JM-M, Polychronis A, Coombes RC and Lam EW-F
Molecular Cancer Therapeutics, American Association For Cancer Research (Aacr) vol. 8 (3), 582-591.  
01-03-2009