Prof Cleo Bishop
Professor of Senescence
Blizard Institute
Queen Mary University of London
Queen Mary University of London
Research
Breast Cancer, Kidney, Skin, Senescence, Ageing, p16
Interests
Cleo’s is the Director of the QMUL Phenotypic Screening Facility, with >18 years experience in compound/genetic high-throughput screening using 2D/3D in vitro models.Her research seeks to illuminate senescence mechanisms, understand how cells age, explore the interplay between healthy ageing and cellular rejuvenation, and target senescence for ageing and cancer therapy.
Ageing team: understand the fundamental mechanisms that senescence heterogeneity; uncover novel routes to cellular rejuvenation; explore how senescence underpins ageing phenotypes; and discover novel senostatics and senolytics for healthy ageing.
Cancer team: how cells sense early carcinogenic events; find mechanisms to selectively trigger senescence in breast cancer; identify new genetic targets for pro-senescence therapy; and discover novel senostatic and senolytic approaches for cancer therapy.
Publications
2025
SAMP-Score: A morphology-based machine learning classification method for screening pro-senescence compounds in p16 positive cancer cellsWallis R, Hughes BK, Moore M, O’Sullivan EA, McIlvenna LC, Gammon L, Hope A, Bellany F et al.
In Cold Spring Harbor Laboratory
12-06-2025
SenPred: a single-cell RNA sequencing-based machine learning pipeline to classify deeply senescent dermal fibroblast cells for the detection of an in vivo senescent cell burdenGenome Medicine, Springer Science and Business Media Llc vol. 17 (1)
14-01-2025
2024
The paradox of senescent-marker positive cancer cells: challenges and opportunitiesO’Sullivan EA, Wallis R, Mossa F, Bishop CL
Npj Aging, Springer Science and Business Media Llc vol. 10 (1)
14-09-2024
The promise of machine learning approaches to capture cellular senescence heterogeneityDuran I, Bishop CL, Gil J, Wallis R
Nature Aging, Springer Science and Business Media Llc vol. 4 (9), 1167-1170.
26-08-2024
Guidelines for minimal information on cellular senescence experimentation in vivoOgrodnik M, Carlos Acosta J, Adams PD, d’Adda di Fagagna F, Baker DJ, Bishop CL, Chandra T, Collado M et al.
Cell, Elsevier Bv vol. 187 (16), 4150-4175.
01-08-2024
An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivoLujan C, Tyler EJ, Ecker S, Webster AP, Stead ER, Martinez-Miguel VE, Milligan D, Garbe JC et al.
Genome Medicine, Springer Science and Business Media Llc vol. 16 (1)
02-07-2024
Author Correction: The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humansLowe R, Overhoff MG, Ramagopalan SV, Garbe JC, Koh J, Stampfer MR, Beach DH, Rakyan VK et al.
Genome Biology, Springer Science and Business Media Llc vol. 25 (1)
10-06-2024
2023
SenPred: A single-cell RNA sequencing-based machine learning pipeline to classify senescent cells for the detection of an in vivo senescent cell burdenIn Research Square Platform Llc
17-11-2023
SenPred: A single-cell RNA sequencing-based machine learning pipeline to classify senescent cells for the detection of anin vivosenescent cell burdenIn Cold Spring Harbor Laboratory
23-10-2023
Death-seq and ye shall find: A novel screening strategy for dying cellsWallis R, Bishop CL
Cell Metabolism, Elsevier Bv vol. 35 (10), 1675-1676.
01-10-2023
P33 Investigating the utility and exploring biological targets of micro-wound healing compounds in 2D and 3D skin modelsGorkic M, Messenger D, Wainwright L, Connelly J, Bishop CL
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e27-e27.
07-07-2023
1454 Investigating the utility and exploring biological targets of micro-wound healing compounds in 2D and 3D skin modelsGorkic M, Messenger D, Wainwright L, Connelly J, Bishop C
Journal of Investigative Dermatology, Elsevier Bv vol. 143 (5), S249-S249.
01-05-2023
Yearning for machine learning: applications for the classification and characterisation of senescenceCell and Tissue Research, Springer Science and Business Media Llc vol. 394 (1), 1-16.
05-04-2023
Investigating the utility and exploring biological targets of micro-wound healing compounds in 2D and 3D skin modelsGorkic M, Messenger D, Wainwright L, Connelly J, Bishop C
01-01-2023
2022
Current Understanding of the Role of Senescent Melanocytes in Skin AgeingBiomedicines, Mdpi Ag vol. 10 (12), 3111-3111.
02-12-2022
Senescence-associated morphological profiles (SAMPs): an image-based phenotypic profiling method for evaluating the inter and intra model heterogeneity of senescenceWallis R, Milligan D, Hughes B, Mizen H, López-Domínguez JA, Eduputa U, Tyler EJ, Serrano M et al.
Aging, Impact Journals, Llc vol. 14 (10), 4220-4246.
16-05-2022
2021
Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining FunctionPalmer A, Epton S, Crawley E, Straface M, Gammon L, Edgar MM, Xu Y, Elahi S et al.
Frontiers in Neuroscience, Frontiers Media Sa vol. 15
07-10-2021
Early growth response 2 (EGR2) is a novel regulator of the senescence programmeAging Cell, Wiley vol. 20 (3)
06-02-2021
Isolation methodology is essential to the evaluation of the extracellular vesicle component of the senescence‐associated secretory phenotypeWallis R, Josipovic N, Mizen H, Robles‐Tenorio A, Tyler EJ, Papantonis A, Bishop CL
Journal of Extracellular Vesicles, Wiley vol. 10 (4)
01-02-2021
2020
Early growth response 2 (EGR2) is a novel regulator of the senescence programIn Cold Spring Harbor Laboratory
01-10-2020
Tissue engineering to better understand senescence: Organotypics come of ageMilligan DA, Tyler EJ, Bishop CL
Mechanisms of Ageing and Development, Elsevier Bv vol. 190, 111261-111261.
01-09-2020
The bright and dark side of extracellular vesicles in the senescence-associated secretory phenotypeWallis R, Mizen H, Bishop CL
Mechanisms of Ageing and Development, Elsevier Bv vol. 189, 111263-111263.
01-07-2020
A multidimensional systems biology analysis of cellular senescence in aging and diseaseAvelar RA, Ortega JG, Tacutu R, Tyler EJ, Bennett D, Binetti P, Budovsky A, Chatsirisupachai K et al.
Genome Biology, Springer Science and Business Media Llc vol. 21 (1)
07-04-2020
2019
A CellAgeClock for expedited discovery of anti-ageing compoundsLujan C, Tyler EJ, Ecker S, Webster AP, Stead ER, Martinez Miguel VE, Milligan D, Garbe JC et al.
In Cold Spring Harbor Laboratory
13-10-2019
Cellular Senescence: Defining a Path ForwardGorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M et al.
Cell, Elsevier Bv vol. 179 (4), 813-827.
01-10-2019
A Multidimensional Systems Biology Analysis of Cellular Senescence in Ageing and DiseaseAvelar RA, Ortega JG, Tacutu R, Tyler E, Bennett D, Binetti P, Budovsky A, Chatsirisupachai K et al.
In Cold Spring Harbor Laboratory
23-08-2019
Cell Migration Dynamics: High‐Content Analysis of Cell Migration Dynamics within a Micropatterned Screening Platform (Adv. Biosys. 8/2019)Almeida FV, Gammon L, Laly AC, Pundel OJ, Bishop CL, Connelly JT
Advanced Biosystems, Wiley vol. 3 (8)
01-08-2019
High‐Content Analysis of Cell Migration Dynamics within a Micropatterned Screening PlatformAlmeida FV, Gammon L, Laly AC, Pundel OJ, Bishop CL, Connelly JT
Advanced Biosystems, Wiley, 1900011-1900011.
13-06-2019
P035 Pharmacological inhibition of the canonical WNT signalling pathway represents a potential novel therapy for fibrosis in Crohn’s diseaseLewis A, Nijhuis A, Berti G, Bishop CL, Feakins R, Lindsay JO, Silver A
25-01-2019
2018
Ribosomal stress-induced senescence as a novel pro-senescence strategy for p16 positive basal-like breast cancerMoore M, Gammon L, Dreger S, Koh J, Garbe JC, Stampfer MR, Philpott M, Jones L et al.
In Cold Spring Harbor Laboratory
14-11-2018
eIF4A2 is a regulator of hypoxic translation and colorectal tumour cell survivalBolland H, McIntyre A, Shams-Nateri A, Bishop C, Silver A
01-01-2018
2017
682 Development of a 3D living skin equivalent to explore the influence of senescence on the skin ageing phenotypeMilligan D, Newman J, Caley M, Wainwright L, Jenkins G, Philpott M, Bishop C
01-10-2017
Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signallingThompson CL, Plant JCT, Wann AKT, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP et al.
European Cells and Materials, Forum Multimedia Publishing Llc vol. 34, 128-141.
20-09-2017
Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistanceNijhuis A, Thompson H, Adam J, Parker A, Gammon L, Lewis A, Bundy JG, Soga T et al.
Human Molecular Genetics, Oxford University Press (Oup) vol. 26 (8), 1552-1564.
16-02-2017
MCL-1 is modulated in Crohn’s disease fibrosis by miR-29b via IL-6 and IL-8Nijhuis A, Curciarello R, Mehta S, Feakins R, Bishop CL, Lindsay JO, Silver A
Cell and Tissue Research, Springer Science and Business Media Llc vol. 368 (2), 325-335.
11-02-2017
2016
Low Stress Ion Conductance Microscopy of Sub-Cellular StiffnessClarke RW, Novak P, Zhukov A, Tyler EJ, Cano-Jaimez M, Drews A, Richards O, Volynski K et al.
Soft Matter, Royal Society of Chemistry (Rsc) vol. 12 (38), 7953-7958.
01-01-2016
2015
The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humansLowe R, Overhoff MG, Ramagopalan SV, Garbe JC, Koh J, Stampfer MR, Beach DH, Rakyan VK et al.
Genome Biology, Springer Science and Business Media Llc vol. 16 (1)
17-09-2015
Low Serum Levels of MicroRNA-19 Are Associated with a Stricturing Crohnʼs Disease PhenotypeLewis A, Mehta S, Hanna LN, Rogalski LA, Jeffery R, Nijhuis A, Kumagai T, Biancheri P et al.
Inflammatory Bowel Diseases, Oxford University Press (Oup) vol. 21 (8), 1926-1934.
01-08-2015
Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and NeurodegenerationMurray A, Letourneau A, Canzonetta C, Stathaki E, Gimelli S, Sloan-Bena F, Abrehart R, Goh P et al.
Stem Cells, Oxford University Press (Oup) vol. 33 (6), 2077-2084.
21-05-2015
A siRNA screen to re-activate senescence in basal-like breast cancerMoore M, Philpott M, Bishop C
Annals of Oncology, Elsevier Bv vol. 26, iii15-iii15.
01-05-2015
2014
In Crohn's disease fibrosis-reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblastsNijhuis A, Biancheri P, Lewis A, Bishop CL, Giuffrida P, Chan C, Feakins R, Poulsom R et al.
Clinical Science, Portland Press Ltd. vol. 127 (5), 341-350.
15-05-2014
2013
Cellular senescence mediated by p16INK4A-coupled miRNA pathwaysOverhoff MG, Garbe JC, Koh J, Stampfer MR, Beach DH, Bishop CL
Nucleic Acids Research, Oxford University Press (Oup) vol. 42 (3), 1606-1618.
09-11-2013
2011
A whole genome screen for HIV restriction factorsLiu L, Oliveira NMM, Cheney KM, Pade C, Dreja H, Bergin A-MH, Borgdorff V, Beach DH et al.
Retrovirology, Springer Science and Business Media Llc vol. 8 (1)
14-11-2011
2010
Primary Cilium-Dependent and -Independent Hedgehog Signaling Inhibits p16(INK4A)Bishop CL, Bergin AMH, Fessart D, Borgdorff V, Hatzimasoura E, Garbe JC, Stampfer MR, Koh J et al.
Mol Cell vol. 40 (4), 533-547.
24-11-2010
Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21(Waf1/Cip1)Borgdorff V, Lleonart ME, Bishop CL, Fessart D, Bergin AH, Overhoff MG, Beach DH
Oncogene vol. 29 (15), 2262-2271.
01-04-2010
2007
The PsbZ subunit of Photosystem II in Synechocystis sp. PCC 6803 modulates electron flow through the photosynthetic electron transfer chainBishop CL, Ulas S, Baena-Gonzalez E, Aro E-M, Purton S, Nugent JHA, Mäenpää P
Photosynthesis Research, Springer Science and Business Media Llc vol. 93 (1-3), 139-147.
22-05-2007
2006
Role for Centromeric Heterochromatin and PML Nuclear Bodies in the Cellular Response to Foreign DNAMolecular and Cellular Biology, Informa Uk Limited vol. 26 (10), 3997-3997.
01-05-2006
Role for centromeric heterochrornatin and PML nuclear bodies in the cellular response to foreign DNABishop CL, Ramalho M, Nadkarni N, Kong WM, Higgins CF, Krauzewicz N
Mol Cell Biol vol. 26 (7), 2583-2594.
01-04-2006
2004
PML nuclear bodies: A site for HDAC repression of VLP mediated gene expression?Ramalho M, Bishop C, Higgins CF, Krauzewicz J
01-01-2004
2003
Molecular analysis of the Chlamydomonas nuclear gene encoding PsbW and demonstration that PsbW is a subunit of photosystem II, but not photosystem IBishop CL, Purton S, Nugent JHA
Plant Molecular Biology, Springer Science and Business Media Llc vol. 52 (2), 285-289.
01-05-2003
Virus-like particles as a model for studying gene deliveryRamalho M, Bishop CL, Higgins CF, Krauzewicz N
01-01-2003
Understanding transcriptional regulation of exogenously delivered DNABishop CL, Ramalho M, McBride AA, Higgins CF, Krauzewicz N
01-01-2003
Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damageBarkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M et al.
Immunity, Elsevier
Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissuesRolas L, Stein M, Barkaway A, Reglero N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L et al.
Embo Reports, Springer
Grants
Grants of specific relevance to Predictive in vitro Models
POC: Senescence in the initiation and progression of prostate cancer in men of African descentCleo Bishop and Prabhakar Rajan
£73,420 Barts and the London Charity
18-06-2025 - 31-03-2026
Development of an Organ-on-a-chip model of polycystic kidney disease using CRISPR modified human kidney cell lineMartin Knight and Cleo Bishop
£39,986 Kidney Research UK
Grant Summary
01-12-2023 - 30-11-2025
Epithelial Exchange Surfaces – From organizing principles to novel culture models of the gatekeepers of the bodyMartin Knight, Hazel Screen, Wen Wang, Clare Thompson and Cleo Bishop
£260,676 EPSRC - EU Scheme
Grant Summary
01-12-2023 - 30-11-2027
Biophysical regulation of nucleolar structure and function in senescent cells and ageingJohn Connelly and Cleo Bishop
£554,319 BBSRC Biotechnology and Biological Sciences Research Council
15-05-2023 - 14-05-2026
Multi-User Equipment Grant,‘Cell DIVE Imager for automated, single cell, multiplexed immunofluorescence microscopyCleo Bishop
£340,339 Wellcome Trust
01-01-2022 - 31-12-2026
Investigating the utility and exploring biological targets of enhanced wound healing compounds in 2DCleo Bishop and John Connelly
£118,835 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2021 - 30-09-2025
Investigating the utility and exploring biological targets of enhanced wound healing compounds in 2DCleo Bishop and John Connelly
£76,000 Unilever UK Ltd
01-10-2021 - 30-09-2025
Investigating the consequences of primary and paracrine driven secondary senescence for melanocyte function in 2D and 3D living skin equivalents - CASE STUDENTSHIPCleo Bishop and Michael Philpott
£114,126 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2020 - 30-09-2024
Investigating the consequences of primary and paracrine-driven secondary senescence in melanocyteCleo Bishop and Michael Philpott
£82,000 Unilever UK Ltd
01-10-2020 - 30-09-2024
CiTI-Pro-senescence therapies for basal-like breast cancer: A novel therapeutic innovationCleo Bishop, Oliver Pearce and John Connelly
£242,221 Barts and the London Charity
01-07-2020 - 31-05-2024
Understanding the mechanobiology of senescence and ageingJohn Connelly and Cleo Bishop
£134,519 DMT Dunhill Medical Trust, The
15-04-2019 - 15-06-2021
Targeting senescence-specific apoptosis resistance genes for the clearance of senescent cells in 2D and 3D human modelsCleo Bishop
£178,534 BBSRC Biotechnology and Biological Sciences Research Council
19-07-2017 - 31-12-2019
Targeting senescence-specific apoptosis resistance for the clearence of senescent cells in 2D and 3D human modelsCleo Bishop
£219,622 Unilever UK Ltd
01-01-2017 - 31-12-2019
High throughput automated confocal imaging systemsCleo Bishop
£307,272 Barts and the London Charity
01-11-2016 - 31-10-2019
Reversing senescence in 3D tissue models of in vitro ageingCleo Bishop
£103,042 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2015 - 30-09-2019
Reversing senescence in 3D tissue models of in vitro agreeingCleo Bishop
£68,000 Unilever UK Ltd
01-10-2015 - 29-02-2020