Prof Cleo Bishop
Professor of Senescence
Blizard Institute
Queen Mary University of London
Queen Mary University of London
Research
Breast Cancer, Kidney, Skin, Senescence, Ageing, p16
Interests
Cleo’s is the Director of the QMUL Phenotypic Screening Facility, with >18 years experience in compound/genetic high-throughput screening using 2D/3D in vitro models.Her research seeks to illuminate senescence mechanisms, understand how cells age, explore the interplay between healthy ageing and cellular rejuvenation, and target senescence for ageing and cancer therapy.
Ageing team: understand the fundamental mechanisms that senescence heterogeneity; uncover novel routes to cellular rejuvenation; explore how senescence underpins ageing phenotypes; and discover novel senostatics and senolytics for healthy ageing.
Cancer team: how cells sense early carcinogenic events; find mechanisms to selectively trigger senescence in breast cancer; identify new genetic targets for pro-senescence therapy; and discover novel senostatic and senolytic approaches for cancer therapy.
Publications
Publications of specific relevance to Predictive <em>in vitro</em> Models2024
The paradox of senescent-marker positive cancer cells: challenges and opportunitiesO’Sullivan EA, Wallis R, Mossa F and Bishop CL
Npj Aging, Springer Nature vol. 10 (1)
14-09-2024
The promise of machine learning approaches to capture cellular senescence heterogeneityDuran I, Bishop CL, Gil J and Wallis R
Nature Aging, Springer Nature vol. 4 (9), 1167-1170.
26-08-2024
Guidelines for minimal information on cellular senescence experimentation in vivoOgrodnik M, Carlos Acosta J, Adams PD, d'Adda di Fagagna F, Baker DJ, Bishop CL, Chandra T, Collado M, Gil J, Gorgoulis V, Gruber F, Hara E, Jansen-Dürr P, Jurk D, Khosla S, Kirkland JL, Krizhanovsky V, Minamino T, Niedernhofer LJ, Passos JF, Ring NAR, Redl H, Robbins PD, Rodier F, Scharffetter-Kochanek K, Sedivy JM, Sikora E, Witwer K, von Zglinicki T and Yun MH
Cell, Elsevier vol. 187 (16), 4150-4175.
01-08-2024
An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivoLujan C, Tyler EJ, Ecker S, Webster AP, Stead ER, Martinez-Miguel VE, Milligan D, Garbe JC, Stampfer MR, Beck S, Lowe R, Bishop CL and Bjedov I
Genome Medicine, Springer Nature vol. 16 (1)
02-07-2024
Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissuesRolas L, Stein M, Barkaway A, Reglero-Real N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L, Golding M, Blacksell IA, Giblin MJ, Jaworska E, Bishop CL, Voisin M-B, Gaston-Massuet C, Fossati-Jimack L, Pitzalis C, Cooper D, Nightingale TD, Lopez-Otin C, Lewis MJ and Nourshargh S
Embo Reports, Springer Nature vol. 25 (9), 3842-3869.
25-06-2024
Author Correction: The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humansLowe R, Overhoff MG, Ramagopalan SV, Garbe JC, Koh J, Stampfer MR, Beach DH, Rakyan VK and Bishop CL
Genome Biology, Springer Nature vol. 25 (1)
10-06-2024
2023
Death-seq and ye shall find: A novel screening strategy for dying cellsWallis R and Bishop CL
Cell Metabolism, Elsevier vol. 35 (10), 1675-1676.
01-10-2023
P33 Investigating the utility and exploring biological targets of micro-wound healing compounds in 2D and 3D skin modelsGorkic M, Messenger D, Wainwright L, Connelly J and Bishop CL
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e27-e27.
07-07-2023
1454 Investigating the utility and exploring biological targets of micro-wound healing compounds in 2D and 3D skin modelsGorkic M, Messenger D, Wainwright L, Connelly J and Bishop C
Journal of Investigative Dermatology, Elsevier vol. 143 (5)
01-05-2023
Yearning for machine learning: applications for the classification and characterisation of senescenceHughes BK, Wallis R and Bishop CL
Cell and Tissue Research, Springer Nature vol. 394 (1), 1-16.
05-04-2023
2022
Current Understanding of the Role of Senescent Melanocytes in Skin AgeingBishop C
Biomedicines, Mdpi vol. 10 (12), 3111-3111.
02-12-2022
Senescence-associated morphological profiles (SAMPs): an image-based phenotypic profiling method for evaluating the inter and intra model heterogeneity of senescenceWallis R, Milligan D, Hughes B, Mizen H, López-Domínguez JA, Eduputa U, Tyler EJ, Serrano M and Bishop CL
Aging, Impact Journals vol. 14 (10), 4220-4246.
16-05-2022
2021
Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining FunctionPalmer A, Epton S, Crawley E, Straface M, Gammon L, Edgar MM, Xu Y, Elahi S, Chin-Aleong J, Martin JE, Bishop CL, Knowles CH and Sanger GJ
Frontiers in Neuroscience vol. 15, 747067-747067.
07-10-2021
Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damageBarkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M, Vázquez-Martínez L, Girbl T, Poston RN, Golding M, Saleeb RS, Thiriot A, von Andrian UH, Duchene J, Voisin M-B, Bishop CL, Voehringer D, Roers A, Rot A, Lämmermann T and Nourshargh S
Immunity, Elsevier vol. 54 (7), 1494-1510.e7.
24-05-2021
Isolation methodology is essential to the evaluation of the extracellular vesicle component of the senescence‐associated secretory phenotypeWallis R, Josipovic N, Mizen H, Robles‐Tenorio A, Tyler EJ, Papantonis A and Bishop CL
Journal of Extracellular Vesicles, Wiley vol. 10 (4)
18-02-2021
Early growth response 2 (EGR2) is a novel regulator of the senescence programmeTyler EJ, del Arroyo AG, Hughes BK, Wallis R, Garbe JC, Stampfer MR, Koh J, Lowe R, Philpott MP and Bishop CL
Aging Cell, Wiley vol. 20 (3)
06-02-2021
2020
Tissue engineering to better understand senescence: Organotypics come of ageMilligan DA, Tyler EJ and Bishop CL
Mechanisms of Ageing and Development, Elsevier vol. 190
24-05-2020
The bright and dark side of extracellular vesicles in the senescence-associated secretory phenotypeWallis R, Mizen H and Bishop CL
Mechanisms of Ageing and Development, Elsevier vol. 189
24-05-2020
A multidimensional systems biology analysis of cellular senescence in aging and diseaseAvelar RA, Ortega JG, Tacutu R, Tyler EJ, Bennett D, Binetti P, Budovsky A, Chatsirisupachai K, Johnson E, Murray A, Shields S, Tejada-Martinez D, Thornton D, Fraifeld VE, Bishop CL and de Magalhães JP
Genome Biology, Springer Nature vol. 21 (1)
07-04-2020
2019
Cellular Senescence: Defining a Path Forward.Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer L, Passos JF, Robbins PD, Schmitt CA, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M and Demaria M
Cell, Elsevier (Cell Press) vol. 179 (4), 813-827.
31-10-2019
High‐Content Analysis of Cell Migration Dynamics within a Micropatterned Screening PlatformAlmeida FV, Gammon L, Laly AC, Pundel OJ, Bishop CL and Connelly JT
Advanced Biosystems, Wiley, 1900011-1900011.
13-06-2019
Cell Migration Dynamics: High‐Content Analysis of Cell Migration Dynamics within a Micropatterned Screening Platform (Adv. Biosys. 8/2019)Almeida FV, Gammon L, Laly AC, Pundel OJ, Bishop CL and Connelly JT
Advanced Biosystems vol. 3 (8), 1970083-1970083.
13-06-2019
2017
Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling.Thompson CL, Plant JC, Wann AK, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP and Knight MM
Eur Cell Mater vol. 34, 128-141.
20-09-2017
Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistanceNijhuis A, Thompson H, Adam J, Parker A, Gammon L, Lewis A, Bundy JG, Tomoyoshi S, Jalaly A, Propper D, Jeffery R, Suraweera N, McDonald S, THAHA MA, Feakins R, Lowe R, Bishop CL and Silver A
, Editors: Davies K and Wynshaw-Boris A. Human Molecular Genetics, Oxford University Press (Oup)
16-02-2017
MCL-1 is modulated in Crohn's disease fibrosis by miR-29b via IL-6 and IL-8.Nijhuis A, Curciarello R, Mehta S, Feakins R, Bishop CL, Lindsay JO and Silver A
Cell Tissue Res
11-02-2017
2016
Low Stress Ion Conductance Microscopy of Sub-Cellular Stiffness.Clarke RW, Novak P, Zhukov A, Tyler EJ, Cano-Jaimez M, Drews A, Richards O, Volynski K, Bishop C and Klenerman D
Soft Matter, Royal Society of Chemistry vol. 12 (38), 7953-7958.
17-08-2016
2015
Low Serum Levels of MicroRNA-19 Are Associated with a Stricturing Crohn's Disease PhenotypeLewis A, Mehta S, Hanna LN, Rogalski LA, Jeffery R, Nijhuis A, Kumagai T, Biancheri P, Bundy JG, Bishop CL, Feakins R, Di Sabatino A, Lee JC, Lindsay JO and Silver A
Inflammatory Bowel Diseases, Oxford University Press (Oup) vol. 21 (8), 1926-1934.
15-05-2015
52P A siRNA screen to re-activate senescence in basal-like breast cancerMoore M, Philpott M and Bishop C
Annals of Oncology, Elsevier vol. 26
01-05-2015
Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and NeurodegenerationMurray A, Letourneau A, Canzonetta C, Stathaki E, Gimelli S, Sloan-Bena F, Abrehart R, Goh P, Lim S, Baldo C, Dagna-Bricarelli F, Hannan S, Mortensen M, Ballard D, Syndercombe Court D, Fusaki N, Hasegawa M, Smart TG, Bishop C, Antonarakis SE, Groet J and Nizetic D
Stem Cells, Wiley Online vol. 33 (6), 2077-2084.
19-02-2015
The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humansLowe R, Overhoff MG, Ramagopalan SV, Garbe JC, Koh J, Stampfer MR, Beach DH, Rakyan VK and Bishop CL
Genome Biology, Springer Nature vol. 16 (1)
01-01-2015
2014
In Crohn's disease fibrosis-reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblasts.Nijhuis A, Biancheri P, Lewis A, Bishop CL, Giuffrida P, Chan C, Feakins R, Poulsom R, Di Sabatino A, Corazza GR, MacDonald TT, Lindsay JO and Silver AR
Clin Sci (Lond) vol. 127 (5), 341-350.
01-09-2014
2013
Cellular senescence mediated by p16INK4A-coupled miRNA pathways.Overhoff MG, Garbe JC, Koh J, Stampfer MR, Beach DH and Bishop CL
Nucleic Acids Research vol. 42 (3), 1606-1618.
11-11-2013
2011
A whole genome screen for HIV restriction factors.Liu L, Oliveira NMM, Cheney KM, Pade C, Dreja H, Bergin A-MH, Borgdorff V, Beach DH, Bishop CL, Dittmar MT and McKnight A
Retrovirology vol. 8
14-11-2011
2010
Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21(Waf1/Cip1).Borgdorff V, Lleonart ME, Bishop CL, Fessart D, Bergin AH, Overhoff MG and Beach DH
Oncogene vol. 29 (15), 2262-2271.
15-04-2010
Primary cilium dependent and independent Hedgehog signaling inhibits p16INK4ABishop CL, Bergin A-M, Fessart D, Borgdorff V, Hatzimasoura E, Garbe JC, Stampfer MR, Koh J and Beach DH
Mol Cell vol. 40 (4), 533-547.
01-01-2010
2007
The PsbZ subunit of photosystem II in Synechocystis sp PCC 6803 modulates electron flow through the photosynthetic electron transfer chainBishop CL, Ulas S, Baena-Gonzalez E, Aro EM, Purton S, Nugent JHA and Maenpaa P
Photosynth Res vol. 93 (1-3), 139-147.
01-07-2007
2006
Role for centromeric heterochromatin and PML nuclear bodies in the cellular response to foreign DNA (vol 26, pg 2583, 2006)Bishop CL, Ramalho M, Nadkarni N, Kong WM, Higgins CF and Krauzewicz N
Mol Cell Biol vol. 26 (10), 3997-3997.
01-05-2006
Role for centromeric heterochromatin and PML nuclear bodies in the cellular response to foreign DNA.Bishop CL, Ramalho M, Nadkarni N, May Kong W, Higgins CF and Krauzewicz N
Mol Cell Biol vol. 26 (7), 2583-2594.
01-04-2006
2003
Molecular analysis of the Chlamydomonas nuclear gene encoding PsbW and demonstration that PsbW is a subunit of photosystem II, but not photosystem IBishop CL, Purton S and Nugent JHA
Plant Mol Biol vol. 52 (2), 285-289.
01-05-2003
Grants
Grants of specific relevance to Predictive in vitro ModelsDevelopment of an Organ-on-a-chip model of polycystic kidney disease using CRISPR modified human kidney cell lineMartin Knight and Cleo Bishop
£39,986 Kidney Research UK
Grant Summary
01-12-2023 - 30-11-2025
Epithelial Exchange Surfaces – From organizing principles to novel culture models of the gatekeepers of the bodyMartin Knight, Hazel Screen, Wen Wang, Clare Thompson and Cleo Bishop
£260,676 EPSRC - EU Scheme
Grant Summary
01-12-2023 - 30-11-2027
Biophysical regulation of nucleolar structure and function in senescent cells and ageingJohn Connelly and Cleo Bishop
£554,319 BBSRC Biotechnology and Biological Sciences Research Council
15-05-2023 - 14-05-2026
Multi-User Equipment Grant,‘Cell DIVE Imager for automated, single cell, multiplexed immunofluorescence microscopyCleo Bishop
£340,339 Wellcome Trust
01-01-2022 - 31-12-2026
Investigating the utility and exploring biological targets of enhanced wound healing compounds in 2DCleo Bishop and John Connelly
£118,835 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2021 - 30-09-2025
Investigating the utility and exploring biological targets of enhanced wound healing compounds in 2DCleo Bishop and John Connelly
£76,000 Unilever UK Ltd
01-10-2021 - 30-09-2025
Investigating the consequences of primary and paracrine driven secondary senescence for melanocyte function in 2D and 3D living skin equivalents - CASE STUDENTSHIPCleo Bishop and Michael Philpott
£114,126 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2020 - 30-09-2024
Investigating the consequences of primary and paracrine-driven secondary senescence in melanocyteCleo Bishop and Michael Philpott
£82,000 Unilever UK Ltd
01-10-2020 - 30-09-2024
CiTI-Pro-senescence therapies for basal-like breast cancer: A novel therapeutic innovationCleo Bishop, Oliver Pearce and John Connelly
£242,221 Barts and the London Charity
01-07-2020 - 31-05-2024
Understanding the mechanobiology of senescence and ageingJohn Connelly and Cleo Bishop
£134,519 DMT Dunhill Medical Trust, The
15-04-2019 - 15-06-2021
Targeting senescence-specific apoptosis resistance genes for the clearance of senescent cells in 2D and 3D human modelsCleo Bishop
£178,534 BBSRC Biotechnology and Biological Sciences Research Council
19-07-2017 - 31-12-2019
Targeting senescence-specific apoptosis resistance for the clearence of senescent cells in 2D and 3D human modelsCleo Bishop
£219,622 Unilever UK Ltd
01-01-2017 - 31-12-2019
High throughput automated confocal imaging systemsCleo Bishop
£307,272 Barts and the London Charity
01-11-2016 - 31-10-2019
Reversing senescence in 3D tissue models of in vitro ageingCleo Bishop
£103,042 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2015 - 30-09-2019
Reversing senescence in 3D tissue models of in vitro agreeingCleo Bishop
£68,000 Unilever UK Ltd
01-10-2015 - 29-02-2020