Prof Cleo Bishop
Professor of Senescence
FMD Blizard
QMUL
QMUL
Research
Breast Cancer, Kidney, Skin, Senescence, Ageing, p16
Interests
Cleo’s is the Director of the QMUL Phenotypic Screening Facility, with >18 years experience in compound/genetic high-throughput screening using 2D/3D in vitro models. Her research seeks to illuminate senescence mechanisms, understand how cells age, explore the interplay between healthy ageing and cellular rejuvenation, and target senescence for ageing and cancer therapy. Ageing team: understand the fundamental mechanisms that senescence heterogeneity; uncover novel routes to cellular rejuvenation; explore how senescence underpins ageing phenotypes; and discover novel senostatics and senolytics for healthy ageing. Cancer team: how cells sense early carcinogenic events; find mechanisms to selectively trigger senescence in breast cancer; identify new genetic targets for pro-senescence therapy; and discover novel senostatic and senolytic approaches for cancer therapy.Publications
Publications of specific relevance to Predictive in vitro Models2024
O’Sullivan EA, Wallis R, Mossa F and Bishop CL (2024). The paradox of senescent-marker positive cancer cells: challenges and opportunities. Springer Nature Npj Aging vol. 10, (1) Duran I, Bishop CL, Gil J and Wallis R (2024). The promise of machine learning approaches to capture cellular senescence heterogeneity. Springer Nature Nature Aging vol. 4, (9) 1167-1170. Ogrodnik M, Carlos Acosta J, Adams PD, d'Adda di Fagagna F, Baker DJ, Bishop CL, Chandra T, Collado M, Gil J, Gorgoulis V, Gruber F, Hara E, Jansen-Dürr P, Jurk D, Khosla S, Kirkland JL, Krizhanovsky V, Minamino T, Niedernhofer LJ, Passos JF, Ring NAR, Redl H, Robbins PD, Rodier F, Scharffetter-Kochanek K, Sedivy JM, Sikora E, Witwer K, von Zglinicki T and Yun MH (2024). Guidelines for minimal information on cellular senescence experimentation in vivo. Elsevier Cell vol. 187, (16) 4150-4175. Lujan C, Tyler EJ, Ecker S, Webster AP, Stead ER, Martinez-Miguel VE, Milligan D, Garbe JC, Stampfer MR, Beck S, Lowe R, Bishop CL and Bjedov I (2024). An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo. Springer Nature Genome Medicine vol. 16, (1) Rolas L, Stein M, Barkaway A, Reglero-Real N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L, Golding M, Blacksell IA, Giblin MJ, Jaworska E, Bishop CL, Voisin M-B, Gaston-Massuet C, Fossati-Jimack L, Pitzalis C, Cooper D, Nightingale TD, Lopez-Otin C, Lewis MJ and Nourshargh S (2024). Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues. Springer Nature Embo Reports vol. 25, (9) 3842-3869. Lowe R, Overhoff MG, Ramagopalan SV, Garbe JC, Koh J, Stampfer MR, Beach DH, Rakyan VK and Bishop CL (2024). Author Correction: The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans. Springer Nature Genome Biology vol. 25, (1) 2023
Wallis R and Bishop CL (2023). Death-seq and ye shall find: A novel screening strategy for dying cells. Elsevier Cell Metabolism vol. 35, (10) 1675-1676. Gorkic M, Messenger D, Wainwright L, Connelly J and Bishop CL (2023). P33 Investigating the utility and exploring biological targets of micro-wound healing compounds in 2D and 3D skin models. Oxford University Press (Oup) British Journal of Dermatology vol. 189, (1) e27-e27. Gorkic M, Messenger D, Wainwright L, Connelly J and Bishop C (2023). 1454 Investigating the utility and exploring biological targets of micro-wound healing compounds in 2D and 3D skin models. Elsevier Journal of Investigative Dermatology vol. 143, (5) Hughes BK, Wallis R and Bishop CL (2023). Yearning for machine learning: applications for the classification and characterisation of senescence. Springer Nature Cell and Tissue Research vol. 394, (1) 1-16. 2022
Bishop C (2022). Current Understanding of the Role of Senescent Melanocytes in Skin Ageing. Mdpi Biomedicines vol. 10, (12) 3111-3111. Wallis R, Milligan D, Hughes B, Mizen H, López-Domínguez JA, Eduputa U, Tyler EJ, Serrano M and Bishop CL (2022). Senescence-associated morphological profiles (SAMPs): an image-based phenotypic profiling method for evaluating the inter and intra model heterogeneity of senescence. Impact Journals Aging vol. 14, (10) 4220-4246. 2021
Palmer A, Epton S, Crawley E, Straface M, Gammon L, Edgar MM, Xu Y, Elahi S, Chin-Aleong J, Martin JE, Bishop CL, Knowles CH and Sanger GJ (2021). Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining Function. Frontiers in Neuroscience vol. 15, 747067-747067. Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M, Vázquez-Martínez L, Girbl T, Poston RN, Golding M, Saleeb RS, Thiriot A, von Andrian UH, Duchene J, Voisin M-B, Bishop CL, Voehringer D, Roers A, Rot A, Lämmermann T and Nourshargh S (2021). Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage. Elsevier Immunity vol. 54, (7) 1494-1510.e7. Wallis R, Josipovic N, Mizen H, Robles‐Tenorio A, Tyler EJ, Papantonis A and Bishop CL (2021). Isolation methodology is essential to the evaluation of the extracellular vesicle component of the senescence‐associated secretory phenotype. Wiley Journal of Extracellular Vesicles vol. 10, (4) Tyler EJ, del Arroyo AG, Hughes BK, Wallis R, Garbe JC, Stampfer MR, Koh J, Lowe R, Philpott MP and Bishop CL (2021). Early growth response 2 (EGR2) is a novel regulator of the senescence programme. Wiley Aging Cell vol. 20, (3) 2020
Milligan DA, Tyler EJ and Bishop CL (2020). Tissue engineering to better understand senescence: Organotypics come of age. Elsevier Mechanisms of Ageing and Development vol. 190, Wallis R, Mizen H and Bishop CL (2020). The bright and dark side of extracellular vesicles in the senescence-associated secretory phenotype. Elsevier Mechanisms of Ageing and Development vol. 189, Avelar RA, Ortega JG, Tacutu R, Tyler EJ, Bennett D, Binetti P, Budovsky A, Chatsirisupachai K, Johnson E, Murray A, Shields S, Tejada-Martinez D, Thornton D, Fraifeld VE, Bishop CL and de Magalhães JP (2020). A multidimensional systems biology analysis of cellular senescence in aging and disease. Springer Nature Genome Biology vol. 21, (1) 2019
Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer L, Passos JF, Robbins PD, Schmitt CA, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M and Demaria M (2019). Cellular Senescence: Defining a Path Forward. Elsevier (Cell Press) Cell vol. 179, (4) 813-827. Almeida FV, Gammon L, Laly AC, Pundel OJ, Bishop CL and Connelly JT (2019). High‐Content Analysis of Cell Migration Dynamics within a Micropatterned Screening Platform. Wiley Advanced Biosystems 1900011-1900011. Almeida FV, Gammon L, Laly AC, Pundel OJ, Bishop CL and Connelly JT (2019). Cell Migration Dynamics: High‐Content Analysis of Cell Migration Dynamics within a Micropatterned Screening Platform (Adv. Biosys. 8/2019). Advanced Biosystems vol. 3, (8) 1970083-1970083. 2017
Thompson CL, Plant JC, Wann AK, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP and Knight MM (2017). Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling. Eur Cell Mater vol. 34, 128-141. Nijhuis A, Thompson H, Adam J, Parker A, Gammon L, Lewis A, Bundy JG, Tomoyoshi S, Jalaly A, Propper D, Jeffery R, Suraweera N, McDonald S, THAHA MA, Feakins R, Lowe R, Bishop CL and Silver A (2017). Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance., Editors: Davies K and Wynshaw-Boris A. Oxford University Press (Oup) Human Molecular Genetics Nijhuis A, Curciarello R, Mehta S, Feakins R, Bishop CL, Lindsay JO and Silver A (2017). MCL-1 is modulated in Crohn's disease fibrosis by miR-29b via IL-6 and IL-8. Cell Tissue Res 2016
Clarke RW, Novak P, Zhukov A, Tyler EJ, Cano-Jaimez M, Drews A, Richards O, Volynski K, Bishop C and Klenerman D (2016). Low Stress Ion Conductance Microscopy of Sub-Cellular Stiffness. Royal Society of Chemistry Soft Matter vol. 12, (38) 7953-7958. 2015
Lewis A, Mehta S, Hanna LN, Rogalski LA, Jeffery R, Nijhuis A, Kumagai T, Biancheri P, Bundy JG, Bishop CL, Feakins R, Di Sabatino A, Lee JC, Lindsay JO and Silver A (2015). Low Serum Levels of MicroRNA-19 Are Associated with a Stricturing Crohn's Disease Phenotype. Oxford University Press (Oup) Inflammatory Bowel Diseases vol. 21, (8) 1926-1934. Moore M, Philpott M and Bishop C (2015). 52P A siRNA screen to re-activate senescence in basal-like breast cancer. Elsevier Annals of Oncology vol. 26, Murray A, Letourneau A, Canzonetta C, Stathaki E, Gimelli S, Sloan-Bena F, Abrehart R, Goh P, Lim S, Baldo C, Dagna-Bricarelli F, Hannan S, Mortensen M, Ballard D, Syndercombe Court D, Fusaki N, Hasegawa M, Smart TG, Bishop C, Antonarakis SE, Groet J and Nizetic D (2015). Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and Neurodegeneration. Wiley Online Stem Cells vol. 33, (6) 2077-2084. Lowe R, Overhoff MG, Ramagopalan SV, Garbe JC, Koh J, Stampfer MR, Beach DH, Rakyan VK and Bishop CL (2015). The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans. Springer Nature Genome Biology vol. 16, (1) 2014
Nijhuis A, Biancheri P, Lewis A, Bishop CL, Giuffrida P, Chan C, Feakins R, Poulsom R, Di Sabatino A, Corazza GR, MacDonald TT, Lindsay JO and Silver AR (2014). In Crohn's disease fibrosis-reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblasts. Clin Sci (Lond) vol. 127, (5) 341-350. 2013
Overhoff MG, Garbe JC, Koh J, Stampfer MR, Beach DH and Bishop CL (2013). Cellular senescence mediated by p16INK4A-coupled miRNA pathways. Nucleic Acids Research vol. 42, (3) 1606-1618. 2011
Liu L, Oliveira NMM, Cheney KM, Pade C, Dreja H, Bergin A-MH, Borgdorff V, Beach DH, Bishop CL, Dittmar MT and McKnight A (2011). A whole genome screen for HIV restriction factors. Retrovirology vol. 8, 2010
Borgdorff V, Lleonart ME, Bishop CL, Fessart D, Bergin AH, Overhoff MG and Beach DH (2010). Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21(Waf1/Cip1). Oncogene vol. 29, (15) 2262-2271. Bishop CL, Bergin A-M, Fessart D, Borgdorff V, Hatzimasoura E, Garbe JC, Stampfer MR, Koh J and Beach DH (2010). Primary cilium dependent and independent Hedgehog signaling inhibits p16INK4A. Mol Cell vol. 40, (4) 533-547. 2007
Bishop CL, Ulas S, Baena-Gonzalez E, Aro EM, Purton S, Nugent JHA and Maenpaa P (2007). The PsbZ subunit of photosystem II in Synechocystis sp PCC 6803 modulates electron flow through the photosynthetic electron transfer chain. Photosynth Res vol. 93, (1-3) 139-147. 2006
Bishop CL, Ramalho M, Nadkarni N, Kong WM, Higgins CF and Krauzewicz N (2006). Role for centromeric heterochromatin and PML nuclear bodies in the cellular response to foreign DNA (vol 26, pg 2583, 2006). Mol Cell Biol vol. 26, (10) 3997-3997. Bishop CL, Ramalho M, Nadkarni N, May Kong W, Higgins CF and Krauzewicz N (2006). Role for centromeric heterochromatin and PML nuclear bodies in the cellular response to foreign DNA. Mol Cell Biol vol. 26, (7) 2583-2594. 2003
Bishop CL, Purton S and Nugent JHA (2003). Molecular analysis of the Chlamydomonas nuclear gene encoding PsbW and demonstration that PsbW is a subunit of photosystem II, but not photosystem I. Plant Mol Biol vol. 52, (2) 285-289. Grants
Grants of specific relevance to Predictive in vitro ModelsDevelopment of an Organ-on-a-chip model of polycystic kidney disease using CRISPR modified human kidMartin Knight and Cleo Bishop
£39,986 Kidney Research UK (01-12-2023 - 30-11-2025)
Epithelial Exchange Surfaces – From organizing principles to novel culture models of the gatekeepers of the body - MSCA-2022-DN Martin KnightMartin Knight, Hazel Screen, Wen Wang, Clare Thompson and Cleo Bishop
£260,676 EPSRC - EU Scheme (01-12-2023 - 30-11-2027)
Unilever Cell Dive Lab services Bishop LabCleo Bishop
£26,795 Unilever UK Ltd (21-08-2023 - 30-04-2024)
Biophysical regulation of nucleolar structure and function in senescent cells and ageingJohn Connelly and Cleo Bishop
£554,319 BBSRC Biotechnology and Biological Sciences Research Council (15-05-2023 - 14-05-2026)
Multi-User Equipment Grant,‘Cell DIVE Imager for automated, single cell, multiplexed immunofluorescence microscopyCleo Bishop
£340,339 Wellcome Trust (01-01-2022 - 31-12-2026)
Investigating the utility and exploring biological targets of enhanced wound healing compounds in 2DCleo Bishop and John Connelly
£76,000 Unilever UK Ltd (01-10-2021 - 30-09-2025)
Investigating the utility and exploring biological targets of enhanced wound healing compounds in 2DCleo Bishop and John Connelly
£118,835 BBSRC Biotechnology and Biological Sciences Research Council (01-10-2021 - 30-09-2025)
Investigating the consequences of primary and paracrine driven secondary senescence for melanocyte function in 2D and 3D living skin equivalents - CASE STUDENTSHIPCleo Bishop and Michael Philpott
£114,126 BBSRC Biotechnology and Biological Sciences Research Council (01-10-2020 - 30-09-2024)
Investigating the consequences of primary and paracrine-driven secondary senescence in melanocyteCleo Bishop and Michael Philpott
£82,000 Unilever UK Ltd (01-10-2020 - 30-09-2024)
CiTI-Pro-senescence therapies for basal-like breast cancer: A novel therapeutic innovationCleo Bishop, Oliver Pearce and John Connelly
£242,221 Barts and the London Charity (01-07-2020 - 31-05-2024)