Novel gastrointestinal tools (GI Tools) for evaluating gut functional capacity in adults with environmental enteropathy in Zambia and Zimbabwe: A cross-sectional study protocol
Phiri TN, Weatherill JW, Monford-Sanchez E, Serrano-Contreras J-I, Melvin C, Kunaka M, Chisenga I, Ngalande P, Mweetwa MN, Besa E, Haider T, Mandal N, Thompson AJ, Edwards CA, Bourke CD, Robertson RC, Posma JM, Banda R, Mwiinga M, Kazhila L, Katsidzira L, Bwakura-Dangarembizi M, Amadi B, Garcia-Perez I, Maitland K, Marchesi JR, Morrison DJ, Frost G and Kelly P
F1000research, F1000research vol. 13 
23-08-2024

Inflammation and cytomegalovirus viremia during pregnancy drive sex-differentiated differences in mortality and immune development in HIV-exposed infants
Bourke C, Evans C, Prendergast A and Kelly M
Nature Communications, Nature Research vol. 15 
17-04-2024

Maternal inflammatory and microbial drivers of low birthweight in low- and middle-income countries
Broad J, Robertson RC, Evans C, Perussolo J, Lum G, Piper JD, Loucaides E, Ziruma A, Chasekwa B, Ntozini R, Bourke CD and Prendergast AJ
Paediatrics and International Child Health, Taylor & Francis vol. 44 (2), 79-93.  
02-04-2024

Inflammation and epithelial repair predict mortality, hospital readmission, and growth recovery in complicated severe acute malnutrition
Sturgeon JP, Tome J, Dumbura C, Majo FD, Ngosa D, Mutasa K, Zyambo K, Besa E, Chandwe K, Kapoma C, Mwapenya B, Nathoo KJ, Bourke CD, Ntozini R, Chasekwa B, Smuk M, Bwakura-Dangarembizi M, Amadi B, Kelly P and Prendergast AJ
Science Translational Medicine, American Association For The Advancement of Science (Aaas) vol. 16 (736), eadh0673-eadh0673.  
28-02-2024

Severe acute malnutrition promotes bacterial binding over pro-inflammatory cytokine secretion by circulating innate immune cells
Bourke C and Robertson R
Science Advances, American Association For The Advancement of Science vol. 9 (44) 
01-11-2023

Severe acute malnutrition promotes bacterial binding over proinflammatory cytokine secretion by circulating innate immune cells
Phiri TN, Mutasa K, Rukobo S, Govha M, Mushayanembwa P, Mwakamui S, Haider T, Zyambo K, Dumbura C, Tome J, Runodamoto T, Chidamba L, Majo FD, Ngosa D, Chandwe K, Kapoma C, Mwapenya B, Mufukari W, Sturgeon JP, Robertson RC, Smuk M, Ntozini R, Nathoo K, Amadi B, Kelly P, Bwakura-Dangarembizi M, Prendergast AJ and Bourke CD
Science Advances, American Association For The Advancement of Science (Aaas) vol. 9 (44), eadh2284-eadh2284.  
01-11-2023

Risk factors for inpatient mortality among children with severe acute malnutrition in Zimbabwe and Zambia
Sturgeon JP, Mufukari W, Tome J, Dumbura C, Majo FD, Ngosa D, Chandwe K, Kapoma C, Mutasa K, Nathoo KJ, Bourke CD, Ntozini R, Bwakura-Dangarembizi M, Amadi B, Kelly P and Prendergast AJ
European Journal of Clinical Nutrition, Springer Nature vol. 77 (9), 895-904.  
08-08-2023

Malnourished Microbes: Host–Microbiome Interactions in Child Undernutrition
Jones HJ, Bourke CD, Swann JR and Robertson RC
Annual Review of Nutrition, Annual Reviews vol. 43 (1), 327-353.  
19-05-2023

Inflammation: the driver of poor outcomes among children with severe acute malnutrition?
Sturgeon JP, Njunge JM, Bourke CD, Gonzales GB, Robertson RC, Bwakura-Dangarembizi M, Berkley JA, Kelly P and Prendergast AJ
Nutrition Reviews, Oxford University Press (Oup) vol. 81 (12), 1636-1652.  
28-03-2023

Child Health, Agriculture and Integrated Nutrition (CHAIN): protocol for a randomised controlled trial of improved infant and young child feeding in rural Zimbabwe
Smith LE, Chagwena DT, Bourke C, Robertson R, Fernando S, Tavengwa NV, Cairns J, Ndhlela T, Matumbu E, Brown T, Datta K, Mutasa B, Tengende A, Chidhanguro D, Langhaug L, Makanza M, Chasekwa B, Mutasa K, Swann J, Kelly P, Ntozini R and Prendergast A
Bmj Open, Bmj vol. 12 (12) 
01-12-2022

Commentary: Mechanisms of kwashiorkor-associated immune suppression: Insights from human, mouse, and pig studies
Gonzales GB, Bourke CD, Sturgeon JP, Njunge JM, Robertson RC, Kelly PM and Berkley JA
Frontiers in Immunology, Frontiers vol. 13 
25-07-2022

Stunting status and exposure to infection and inflammation in early life shape anti-bacterial immune cell function among Zimbabwean children
Bourke C
Frontiers in Immunology, Frontiers Media vol. 13 
13-06-2022

Recovery of children following hospitalization for complicated severe acute malnutrition in Zimbabwe and Zambia
Bourke C
Maternal and Child Nutrition, Wiley Open Access 
22-12-2021

Understanding the role of the gut in undernutrition: what can technology tell us?
Thompson A, Bourke C, Roberston R, Shivakumar N, Edwards C, Preston T, Holmes E, Kelly M, Frost G, Morrison D and On behalf of the HUNGer Consortium
Gut, Bmj Publishing Group 
09-06-2021

Risk factors for postdischarge mortality following hospitalization for severe acute malnutrition in Zimbabwe and Zambia
Bwakura-Dangarembizi M, Dumbura C, Amadi B, Ngosa D, Majo FD, Nathoo KJ, Mwakamui S, Mutasa K, Chasekwa B, Ntozini R, Kelly P, Prendergast AJ, Besa E, Claire DB, Chakara P, Chidamba L, Chidawanyika T, Chidhanguro T, Chifunda K, Chilala E, Chingaoma L, Chipunza M, Chulu N, Dandadzi A, Dumba T, Dune W, Gondwe T, Govha M, Gwanzura K and Humphrey HJ
American Journal of Clinical Nutrition, Elsevier vol. 113 (3), 665-674.  
20-01-2021

Can breastfeeding protect against antimicrobial resistance?
Nadimpalli ML, Bourke CD, Robertson RC, Delarocque-Astagneau E, Manges AR and Pickering AJ
Bmc Medicine, Springer Nature vol. 18 (1) 
01-12-2020

Strain-level analysis of gut-resident pro-inflammatory viridans group Streptococci suppressed by long-term cotrimoxazole prophylaxis among HIV-positive children in Zimbabwe
Gough E, Bourke C, Berejena C, Shonhai A, Bwakura-Dangarembizi M, Prendergast A and Manges AR
Gut Microbes, Taylor & Francis 
05-02-2020

Determinants of urogenital schistosomiasis among pregnant women and its impact on pregnancy outcomes, neonatal deaths and child growth
Bourke C
Journal of Infectious Diseases, Oxford University Press (Oup) 
13-12-2019

Cotrimoxazole prophylaxis selects for antimicrobial resistance in HIV-exposed uninfected infants
Bourke C and Evans C
Clinical Infectious Diseases, Oxford University Press (Oup) 
13-12-2019

The Anti-inflammatory Effects of Cotrimoxazole Prophylaxis for People Living With Human Immunodeficiency Virus in Sub-Saharan Africa
Bourke CD and Prendergast AJ
The Journal of Infectious Diseases, Oxford University Press (Oup) vol. 222 (3), 347-350.  
23-10-2019

Current understanding of innate immune cell dysfunction in childhood undernutrition
Bourke C, Jones KDJ and Prendergast AJ
Frontiers in Immunology, Frontiers Media 
29-07-2019

Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation
BOURKE CD, PRENDERGAST A, DEAYTON J, PARDIEU C and Naheed C
Science Translational Medicine, American Association For The Advancement of Science vol. 11 
03-04-2019

Children With Noncritical Infections Have Increased Intestinal Permeability, Endotoxemia and Altered Innate Immune Responses
Sturgeon JP, Bourke CD and PRENDERGAST AJ
The Pediatric Infectious Disease Journal, Ovid Technologies (Wolters Kluwer Health), 1-1.  
01-04-2019

Health Outcomes, Pathogenesis and Epidemiology of Severe Acute Malnutrition (HOPE-SAM): rationale and methods of a longitudinal observational study
BOURKE CD, PRENDERGAST A and ROBERTSON R
Bmj Open, Bmj Journals 
01-02-2019

Health outcomes in Undernutrition: the role of nutrients, gut dysfunction and the gut microbiome (HUNGer)
Bourke C
 
01-01-2019

Schistosomiasis in the first 1000 days
Freer JB, Bourke CD, Durhuus GH, Kjetland EF and Prendergast AJ
The Lancet Infectious Diseases, Elsevier vol. 18 (6), e193-e203.  
20-11-2017

Immune Dysfunction as a Cause and Consequence of Malnutrition
BOURKE CD, Berkley JA and Prendergast AJ
Trends in Immunology, Elsevier (Cell Press) vol. 37 (6), 386-398.  
26-05-2016

Helminth Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4+ T Cells That Are Functionally Suppressive
Sanin DE, Prendergast CT, Bourke CD and Mountford AP
Plos Pathogens, Public Library of Science (Plos) vol. 11 (5) 
14-05-2015

A Meta-Analysis of Experimental Studies of Attenuated Schistosoma mansoni Vaccines in the Mouse Model
Fukushige M, Mitchell KM, Bourke CD, Woolhouse MEJ and Mutapi F
Frontiers in Immunology, Frontiers vol. 6 
27-02-2015

Down Regulation of the TCR Complex CD3ζ-Chain on CD3+ T Cells: A Potential Mechanism for Helminth-Mediated Immune Modulation
Appleby LJ, Nausch N, Heard F, Erskine L, Bourke CD, Midzi N, Mduluza T, Allen JE and Mutapi F
Frontiers in Immunology, Frontiers vol. 6 
18-02-2015

Epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous schistosome infection
Bourke CD, Prendergast CT, Sanin DE, Oulton TE, Hall RJ and Mountford AP
International Journal For Parasitology, Elsevier vol. 45 (4), 215-224.  
06-01-2015

CD16 Expression on Monocytes in Healthy Individuals but Not Schistosome-Infected Patients Is Positively Associated with Levels of Parasite-Specific IgG and IgG1
Appleby LJ, Nausch N, Erskine L, Bourke CD, Rujeni N, Midzi N, Mduluza T and Mutapi F
Plos Neglected Tropical Diseases, Public Library of Science (Plos) vol. 8 (8) 
07-08-2014

Cytokine Responses to the Anti-schistosome Vaccine Candidate Antigen Glutathione-S-transferase Vary with Host Age and Are Boosted by Praziquantel Treatment
Bourke CD, Nausch N, Rujeni N, Appleby LJ, Trottein F, Midzi N, Mduluza T and Mutapi F
Plos Neglected Tropical Diseases, Public Library of Science (Plos) vol. 8 (5) 
08-05-2014

Circulating CD14brightCD16+ ‘Intermediate’ Monocytes Exhibit Enhanced Parasite Pattern Recognition in Human Helminth Infection
Turner JD, Bourke CD, Meurs L, Mbow M, Dièye TN, Mboup S, Polman K and Mountford AP
Plos Neglected Tropical Diseases, Public Library of Science (Plos) vol. 8 (4) 
24-04-2014

Schistosome infection is associated with enhanced whole‐blood IL‐10 secretion in response to cercarial excretory/secretory products
Turner JD, Meurs L, Dool P, Bourke CD, Mbow M, Dièye TN, Mboup S, Polman K and Mountford AP
Parasite Immunology, Wiley vol. 35 (5-6), 147-156.  
01-05-2013

Integrated Analysis of Innate, Th1, Th2, Th17, and Regulatory Cytokines Identifies Changes in Immune Polarisation Following Treatment of Human Schistosomiasis
Bourke CD, Nausch N, Rujeni N, Appleby LJ, Mitchell KM, Midzi N, Mduluza T and Mutapi F
The Journal of Infectious Diseases, Oxford University Press (Oup) vol. 208 (1), 159-169.  
08-10-2012

Trichuris suis ova therapy for allergic rhinitis does not affect allergen-specific cytokine responses despite a parasite-specific cytokine response
Bourke CD, Mutapi F, Nausch N, Photiou DMF, Poulsen LK, Kristensen B, Arnved J, Rønborg S, Roepstorff A, Thamsborg S, Kapel C, Melbye M and Bager P
Clinical & Experimental Allergy vol. 42 (11), 1582-1595.  
01-07-2012

Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium
Nausch N, Bourke CD, Appleby LJ, Rujeni N, Lantz O, Trottein F, Midzi N, Mduluza T and Mutapi F
Scientific Reports, Springer Nature vol. 2 (1) 
01-01-2012

Age-Related Patterns in Human Myeloid Dendritic Cell Populations in People Exposed to Schistosoma haematobium Infection
Nausch N, Louis D, Lantz O, Peguillet I, Trottein F, Chen IYD, Appleby LJ, Bourke CD, Midzi N, Mduluza T and Mutapi F
Plos Neglected Tropical Diseases, Public Library of Science (Plos) vol. 6 (9) 
01-01-2012

Chitinase 3-Like 1 Protein Levels Are Elevated in Schistosoma haematobium Infected Children
Appleby LJ, Nausch N, Bourke CD, Rujeni N, Midzi N, Mduluza T, Allen JE and Mutapi F
Plos Neglected Tropical Diseases, Public Library of Science (Plos) vol. 6 (11) 
01-01-2012

Atopy Is Inversely Related to Schistosome Infection Intensity: A Comparative Study in Zimbabwean Villages with Distinct Levels of Schistosoma haematobium Infection
Rujeni N, Nausch N, Bourke CD, Midzi N, Mduluza T, Taylor DW and Mutapi F
International Archives of Allergy and Immunology, Karger Publishers vol. 158 (3), 288-298.  
01-01-2012

The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ production
Paveley RA, Aynsley SA, Turner JD, Bourke CD, Jenkins SJ, Cook PC, Martinez-Pomares L and Mountford AP
International Journal For Parasitology, Elsevier vol. 41 (13-14), 1335-1345.  
14-10-2011

Exposure, infection, systemic cytokine levels and antibody responses in young children concurrently exposed to schistosomiasis and malaria
IMAI N, RUJENI N, NAUSCH N, BOURKE CD, APPLEBY LJ, COWAN G, GWISAI R, MIDZI N, CAVANAGH D, MDULUZA T, TAYLOR D and MUTAPI F
Parasitology, Cambridge University Press (Cup) vol. 138 (12), 1519-1533.  
04-08-2011

Schistosome Infection Intensity Is Inversely Related to Auto-Reactive Antibody Levels
Mutapi F, Imai N, Nausch N, Bourke CD, Rujeni N, Mitchell KM, Midzi N, Woolhouse MEJ, Maizels RM and Mduluza T
Plos One, Public Library of Science (Plos) vol. 6 (5) 
06-05-2011

Schistosoma haematobium Treatment in 1–5 Year Old Children: Safety and Efficacy of the Antihelminthic Drug Praziquantel
Mutapi F, Rujeni N, Bourke C, Mitchell K, Appleby L, Nausch N, Midzi N and Mduluza T
Plos Neglected Tropical Diseases, Public Library of Science (Plos) vol. 5 (5) 
01-05-2011

Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4
MUTAPI F, BOURKE C, HARCUS Y, MIDZI N, MDULUZA T, TURNER CM, BURCHMORE R and MAIZELS RM
Parasite Immunology, Wiley vol. 33 (3), 181-192.  
10-02-2011

Acquired immune heterogeneity and its sources in human helminth infection
BOURKE CD, MAIZELS RM and MUTAPI F
Parasitology, Cambridge University Press (Cup) vol. 138 (2), 139-159.  
15-10-2010