Dr Christoph Engl

Christoph Engl

Senior Lecturer in Microbiology

School of Biological and Behavioural Sciences
Queen Mary University of London

Research

Bacteria, Cell Biology, Molecular Biology, Single cell imaging and spectroscopy

Interests

My lab is interested in understanding how bacteria adapt to and shape their environment. We study the biology and behaviour of bacterial cells from single molecules and single cells to population level.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2022

Kotta-Loizou I, Giuliano MG, Jovanovic M, Schaefer J, Ye F, Zhang N, Irakleidi DA, Liu X, Zhang X, Buck M and Engl C (2022). The RNA repair proteins RtcAB regulate transcription activator RtcR via its CRISPR-associated Rossmann fold domain. Cell Press  iScience  105425-105425.  
Bashir T, Brackston RD, Waite C, Kotta-Loizou I, Carey MR, Engl C, Buck M and Schumacher J (2022). Molecular Origins of Transcriptional Heterogeneity in Diazotrophic Klebsiella oxytoca. American Society for Microbiology  mSystems  e0059622-e0059622.  

2021

Giuliano MG and Engl C (2021). The Lifecycle of Ribosomal RNA in Bacteria. RNA Damage and Repair  Springer Nature   

2020

Mahbub M, Hemm L, Yang Y, Kaur R, Carmen H, Engl C, Huokko T, Riediger M, Watanabe S, Liu L-N, Wilde A, Hess WR and Mullineaux CW (2020). mRNA localization, reaction centre biogenesis and thylakoid membrane targeting in cyanobacteria. Springer Nature  Nature Plants  vol. 6, (9) 1179-1191.  
Engl C, Jovanovic G, Brackston RD, Kotta-Loizou I and Buck M (2020). The route to transcription initiation determines the mode of transcriptional bursting in E. coli. Nature Research (part of Springer Nature)  Nature Communications  vol. 11,  

2019

Kotta-Loizou I, Jovanovic M, Schaefer J, Engl C, Zhang N and Buck M (2019). A CRISPR-associated Rossmann fold (CARF) domain regulates transcription of an RNA repair system in Escherichia coli. Microbiology Society  Access Microbiology  vol. 1, (1A)  

2018

Engl C (2018). Noise in bacterial gene expression. Portland Press  Biochemical Society Transactions  vol. 47, (1) 209-217.  
Finch EA, Caruso T and ENGL CM (2018). Effects of Paenibacillus polymyxa inoculation on below-ground nematode communities and plant growth. Elsevier  Soil Biology and Biochemistry  vol. 121, 1-7.  

2017

George TS, Giles CD, Menezes-Blackburn D, Condron LM, Gama-Rodrigues AC, Jaisi D, Lang F, Neal AL, Stutter MI, Almeida DS, Bol R, Cabugao KG, Celi L, Cotner JB, Feng G, Goll DS, Hallama M, Krueger J, Plassard C, Rosling A, Darch T, Fraser T, Giesler R, Richardson AE, Tamburini F, Shand CA, Lumsdon DG, Zhang H, Blackwell MSA and Wearing C (2017). Correction to: Organic phosphorus in the terrestrial environment: a perspective on the state of the art and future priorities (Plant and Soil, (2018), 427, 1-2, (191-208), 10.1007/s11104-017-3391-x). Plant and Soil  vol. 427, (1-2) 209-211.  
George TS, Giles CD, Menezes-Blackburn D, Condron LM, Gama-Rodrigues AC, Jaisi D, Lang F, Neal AL, Stutter MI, Almeida DS, Bol R, Cabugao KG, Celi L, Cotner JB, Feng G, Goll DS, Hallama M, Krueger J, Plassard C, Rosling A, Darch T, Fraser T, Giesler R, Richardson AE, Tamburini F, Shand CA, Lumsdon DG, Zhang H, Blackwell MSA and Wearing C (2017). Organic phosphorus in the terrestrial environment: a perspective on the state of the art and future priorities. Plant and Soil   
Sihto H-M, Stephan R, Engl C, Chen J and Johler S (2017). Effect of food-related stress conditions and loss of agr and sigB on seb promoter activity in S. aureus. Food Microbiology  vol. 65, 205-212.  

2016

Engl C, Schaefer J, Kotta-Loizou I and Buck M (2016). Cellular and molecular phenotypes depending upon the RNA repair system RtcAB of Escherichia coli. Nucleic Acids Research  gkw628-gkw628.  

2015

Schaefer J, Engl C, Zhang N, Lawton E and Buck M (2015). Genome wide interactions of wild-type and activator bypass forms of σ54. Nucleic Acids Research  vol. 43, (15) 7280-7291.  
ENGL CHRISTOPH (2015). In Vitro and In Vivo Methodologies for Studying the Sigma 54-Dependent Transcription. Bacterial Transcriptional Control   

2014

Engl C, Waite CJ, McKenna JF, Bennett MH, Hamann T and Buck M (2014). Chp8, a Diguanylate Cyclase from Pseudomonas syringae pv. Tomato DC3000, Suppresses the Pathogen-Associated Molecular Pattern Flagellin, Increases Extracellular Polysaccharides, and Promotes Plant Immune Evasion. mBio  vol. 5, (3) e01168-14-e01168-14.  

2013

Mehta P, Jovanovic G, Lenn T, Bruckbauer A, Engl C, Ying L and Buck M (2013). Dynamics and stoichiometry of a regulated enhancer-binding protein in live Escherichia coli cells. Springer Nature  Nature Communications  vol. 4, (1)  

2012

Johler S, Moser M, Engl C, Tasara T, Corti S, Chen J and Stephan R (2012). A Coagulase- and α-Glucosidase-Negative Variant of Staphylococcus aureus: a Challenge for Routine Microbiological Diagnostics. American Society for Microbiology  Journal of Clinical Microbiology  vol. 50, (5) 1827-1828.  

2011

Engl C, Beek AT, Bekker M, de Mattos JT, Jovanovic G and Buck M (2011). Dissipation of Proton Motive Force is not Sufficient to Induce the Phage Shock Protein Response in Escherichia coli. Springer Nature  Current Microbiology  vol. 62, (5) 1374-1385.  

2010

Huvet M, Toni T, Sheng X, Thorne T, Jovanovic G, Engl C, Buck M, Pinney JW and Stumpf MPH (2010). The Evolution of the Phage Shock Protein Response System: Interplay between Protein Function, Genomic Organization, and System Function. Oxford University Press (OUP)  Molecular Biology and Evolution  vol. 28, (3) 1141-1155.  
Lenn T, Gkekas CN, Bernard L, Engl C, Jovanovic G, Buck M and Ying L (2010). Measuring the stoichiometry of functional PspA complexes in living bacterial cells by single molecule photobleaching. Royal Society of Chemistry (RSC)  Chem. Commun.  vol. 47, (1) 400-402.  
Joly N, Engl C, Jovanovic G, Huvet M, Toni T, Sheng X, Stumpf MPH and Buck M (2010). Managing membrane stress: the phage shock protein (Psp) response, from molecular mechanisms to physiology. Oxford University Press (OUP)  FEMS Microbiology Reviews  vol. 34, (5) 797-827.  
Jovanovic G, Engl C, Mayhew AJ, Burrows PC and Buck M (2010). Properties of the phage-shock-protein (Psp) regulatory complex that govern signal transduction and induction of the Psp response in Escherichia coli. Microbiology Society  Microbiology  vol. 156, (10) 2920-2932.  

2009

Joly N, Burrows PC, Engl C, Jovanovic G and Buck M (2009). A Lower-Order Oligomer Form of Phage Shock Protein A (PspA) Stably Associates with the Hexameric AAA+ Transcription Activator Protein PspF for Negative Regulation. Elsevier  Journal of Molecular Biology  vol. 394, (4) 764-775.  
Jovanovic G, Engl C and Buck M (2009). Physical, functional and conditional interactions between ArcAB and phage shock proteins upon secretin‐induced stress in Escherichia coli. Wiley  Molecular Microbiology  vol. 74, (1) 16-28.  
Huvet M, Toni T, Tan H, Jovanovic G, Engl C, Buck M and Stumpf MPH (2009). Model-based evolutionary analysis: the natural history of phage-shock stress response. Portland Press  Biochemical Society Transactions  vol. 37, (4) 762-767.  
Engl C, Jovanovic G, Lloyd LJ, Murray H, Spitaler M, Ying L, Errington J and Buck M (2009). In vivo localizations of membrane stress controllers PspA and PspG inEscherichia coli. Wiley  Molecular Microbiology  vol. 73, (3) 382-396.