Dr Claudio Raimondi
Lecturer
Queen Mary University of London
Research
Endothelial Cells, Vascular Biology, Shear Stress, Cell Junctions, Cell Signalling, Vascular Inflammation
Interests
My lab focuses on investigating on signalling pathways modulated by shear stress that regulates vascular inflammation. We use an Ibidi 2D shear stress system and we are interested in expanding our focus on more complex 3D organ on chips.Publications
2024
Chikh A and Raimondi C (2024). Endothelial Neuropilin-1: a multifaced signal transducer with an emerging role in inflammation and atherosclerosis beyond angiogenesis. Portland Press Biochemical Society Transactions vol. 52, (1) 137-150. 2023
Massimo G, Khambata RS, Chapman T, Birchall K, Raimondi C, Shabbir A, Dyson N, Rathod K, Borghi C and Ahluwalia A (2023). Corrigendum to “Natural mutations of human XDH promote the nitrite (NO2 −)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?” [Redox Biol. 4 (67) (2023) 102864]. Elsevier Redox Biology vol. 67, Massimo G, Khambata RS, Chapman T, Birchall K, Raimondi C, Shabbir A, Dyson N, Rathod KS, Borghi C and Ahluwalia A (2023). Natural mutations of human XDH promote the nitrite (NO2 −)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health? Elsevier Redox Biology vol. 67, Bosseboeuf E, Chikh A, Chaker AB, Mitchell TP, Vignaraja D, Rajendrakumar R, Khambata RS, Nightingale TD, Mason JC, Randi AM, Ahluwalia A and Raimondi C (2023). Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow. American Association for the Advancement of Science (AAAS) Science Signaling vol. 16, (786) 2022
Chikh A, Sanzà P, Raimondi C, Akinduro O, Warnes G, Chiorino G, Byrne C, Harwood CA and Bergamaschi D (2022). Retraction: iASPP is a novel autophagy inhibitor in keratinocytes. The Company of Biologists Journal of Cell Science vol. 135, (14) 2020
Dufton NP, Peghaire CR, Osuna-Almagro L, Raimondi C, Kalna V, Chauhan A, Webb G, Yang Y, Birdsey GM, Lalor P, Mason JC, Adams DH and Randi AM (2020). Author Correction: Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis (Nature Communications, (2017), 8, 1, (895), 10.1038/s41467-017-01169-0). Nature Communications vol. 11, (1) Bosseboeuf E and Raimondi C (2020). Signalling, Metabolic Pathways and Iron Homeostasis in Endothelial Cells in Health, Atherosclerosis and Alzheimer’s Disease. MDPI Cells vol. 9, (9) 2019
Peghaire C, Dufton NP, Lang M, Salles-Crawley II, Ahnström J, Kalna V, Raimondi C, Pericleous C, Inuabasi L, Kiseleva R, Muzykantov VR, Mason JC, Birdsey GM and Randi AM (2019). The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature. Springer Nature Nature Communications vol. 10, (1) 2018
Issitt T, Bosseboeuf E, De Winter N, Dufton N, Gestri G, Senatore V, Chikh A, Randi AM and Raimondi C (2018). Neuropilin-1 Controls Endothelial Homeostasis by Regulating Mitochondrial Function and Iron-Dependent Oxidative Stress. Elsevier iScience vol. 11, 205-223. 2017
Dufton NP, Peghaire CR, Osuna-Almagro L, Raimondi C, Kalna V, Chauhan A, Webb G, Yang Y, Birdsey GM, Lalor P, Mason JC, Adams DH and Randi AM (2017). Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis. Springer Nature Nature Communications vol. 8, (1) Fantin A, Lampropoulou A, Senatore V, Brash JT, Prahst C, Lange CA, Liyanage SE, Raimondi C, Bainbridge JW, Augustin HG and Ruhrberg C (2017). VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation. Rockefeller University Press Journal of Experimental Medicine vol. 214, (4) 1049-1064. Raimondi C, Chikh A, Wheeler AP, Maffucci T and Falasca M (2017). Correction: A novel regulatory mechanism links PLCγ1 to PDK1. The Company of Biologists Journal of Cell Science vol. 130, (5) 1016-1016. 2016
Raimondi C, Calleja V, Ferro R, Fantin A, Riley AM, Potter BVL, Brennan CH, Maffucci T, Larijani B and Falasca M (2016). A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion. Nature Publishing Group: Open Access Journals - Option C Scientific Reports vol. 6, 26142-26142. 2014
Raimondi C, Fantin A, Lampropoulou A, Denti L, Chikh A and Ruhrberg C (2014). Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. J Exp Med vol. 211, (6) 1167-1183. Chikh A, Sanza P, Raimondi C, Akinduro O, Warnes G, Chiorino G, Byrne C, Harwood CA and Bergamaschi D (2014). IASPP is a novel autophagy mudulator in keratinocytes. Company of Biologists J Cell Science vol. 127, (14) 3079-3093. 2012
Raimondi C, Chikh A, Wheeler AP, Maffucci T and Falasca M (2012). A novel regulatory mechanism links PLCγ1 to PDK1. J Cell Sci vol. 125, (Pt 13) 3153-3163. Raimondi C and Falasca M (2012). Phosphoinositides signalling in cancer: focus on PI3K and PLC. Adv Biol Regul vol. 52, (1) 166-182. 2011
Chikh A, Matin RNH, Senatore V, Hufbauer M, Lavery D, Raimondi C, Ostano P, Mello-Grand M, Ghimenti C, Bahta A, Khalaf S, Akgül B, Braun KM, Chiorino G, Philpott MP, Harwood CA and Bergamaschi D (2011). iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia. EMBO J vol. 30, (20) 4261-4273. Dominguez V, Raimondi C, Somanath S, Bugliani M, Loder MK, Edling CE, Divecha N, da Silva-Xavier G, Marselli L, Persaud SJ, Turner MD, Rutter GA, Marchetti P, Falasca M and Maffucci T (2011). Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells. J Biol Chem vol. 286, (6) 4216-4225. Raimondi C and Falasca M (2011). Targeting PDK1 in cancer. Curr Med Chem vol. 18, (18) 2763-2769. Falasca M, Raimondi C and Maffucci T (2011). Boyden chamber. Methods Mol Biol vol. 769, 87-95. 2009
Maffucci T, Raimondi C, Abu-Hayyeh S, Dominguez V, Sala G, Zachary I and Falasca M (2009). A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation. PLoS One vol. 4, (12) 2008
Sala G, Dituri F, Raimondi C, Previdi S, Maffucci T, Mazzoletti M, Rossi C, Iezzi M, Lattanzio R, Piantelli M, Iacobelli S, Broggini M and Falasca M (2008). Phospholipase Cgamma1 is required for metastasis development and progression. Cancer Res vol. 68, (24) 10187-10196. 1992
Astorri E, Ferrari O, Lima G, Garini A, Arisi M, Manzetti G and Raimondi C (1992). Prognostic significance of thallium-201 scintigraphy in patients with previous myocardial infarct. Minerva Cardioangiologica vol. 40, (1-2) 7-13. Grants
Neuropilin-1 is a novel iron-induced gene that protects vascular functionClaudio Raimondi
£43,361 Barts and the London Charity (15-09-2023 - 01-02-2025)
Role of microvascular dysfunction in MELAS: impact of a mtDNA mutation on microvascular functionClaudio Raimondi
£27,000 BHF British Heart Foundation (01-03-2023 - 28-02-2026)
ABCB8 is a novel regulator of endothelial function and homeostasisClaudio Raimondi
£221,021 Barts and the London Charity (25-10-2021 - 23-01-2025)
Role of neuropilin-1 in controlling endothelial cell senescence and TGF-beta signalling in atherosclerosis and peripheral arterial diseaseClaudio Raimondi
£291,075 BHF British Heart Foundation (01-09-2016 - 31-08-2022)