Dr Charalampos (Babis) Rallis
Reader In Genetics, Genomics and Fundamental Cell Biology
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
Ageing, Senescence, Cancer, Eaxtracellular matrix, Nutrient perception, Gene expression
Interests
We study gene and protein networks implicated in cellular fitness and metabolism, neurodegeneration, cancer and ageing. Our aim is to elucidate the molecular mechanisms and principles behind senescence and lifespan and apply this knowledge for the amelioration of age-related diseases. We utilise cell-based systems and phenocopy in vivo normal and pathological situations using human neuronal and fibroblastic systems. We have established ageing and neurodegeneration models and can intervene genetically and pharmacologically.Publications
2023
Islam RA and Rallis C (2023). Correction: Islam, R.A.; Rallis, C. Ribosomal Biogenesis and Heterogeneity in Development, Disease, and Aging. Epigenomes 2023, 7, 17. MDPI Epigenomes vol. 7, (4) Gal C, Cochrane GA, Morgan BA, Rallis C, Bähler J and Whitehall SK (2023). The longevity and reversibility of quiescence in Schizosaccharomyces pombe are dependent upon the HIRA histone chaperone. Taylor & Francis Cell Cycle vol. 22, (17) 1921-1936. Islam RA and Rallis C (2023). Ribosomal Biogenesis and Heterogeneity in Development, Disease, and Aging. MDPI Epigenomes vol. 7, (3) Alao J-P, Legon L, Dabrowska A, Tricolici A-M, Kumar J and Rallis C (2023). Interplays of AMPK and TOR in Autophagy Regulation in Yeast. MDPI Cells vol. 12, (4) 2022
Dabrowska A, Kumar J and Rallis C (2022). Nutrient-Response Pathways in Healthspan and Lifespan Regulation. MDPI Cells vol. 11, (9) 2021
Martinez-Miguel VE, Lujan C, Espie--Caullet T, Martinez-Martinez D, Moore S, Backes C, Gonzalez S, Galimov ER, Brown AEX, Halic M, Tomita K, Rallis C, von der Haar T, Cabreiro F and Bjedov I (2021). Increased fidelity of protein synthesis extends lifespan. Elsevier Cell Metabolism vol. 33, (11) 2288-2300.e12. Legon L and Rallis C (2021). Genome-wide screens in yeast models towards understanding chronological lifespan regulation. Oxford University Press (OUP) Briefings in Functional Genomics vol. 21, (1) 4-12. Alao J-P, Legon L and Rallis C (2021). Crosstalk between the mTOR and DNA Damage Response Pathways in Fission Yeast. MDPI Cells vol. 10, (2) 2020
Rallis C, Mülleder M, Smith G, Au YZ, Ralser M and Bähler J (2020). Amino Acids Whose Intracellular Levels Change Most During Aging Alter Chronological Life Span of Fission Yeast. Oxford University Press (OUP) The Journals of Gerontology Series A vol. 76, (2) 205-210. Alao JP, Johansson-Sjölander J, Rallis C and Sunnerhagen P (2020). Caffeine Stabilises Fission Yeast Wee1 in a Rad24-Dependent Manner but Attenuates Its Expression in Response to DNA Damage. MDPI Microorganisms vol. 8, (10) Bjedov I and Rallis C (2020). The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation. MDPI Genes vol. 11, (9) Rodríguez-López M, Gonzalez S, Hillson O, Tunnacliffe E, Codlin S, Tallada VA, Bähler J and Rallis C (2020). The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1. Elsevier Cell Reports vol. 30, (10) 3240-3249.e4. 2019
Pai C-C, Hsu K-F, Durley SC, Keszthelyi A, Kearsey SE, Rallis C, Folkes LK, Deegan R, Wilkins SE, Pfister SX, De León N, Schofield CJ, Bähler J, Carr AM and Humphrey TC (2019). An essential role for dNTP homeostasis following CDK-induced replication stress. The Company of Biologists Journal of Cell Science vol. 132, (6) 2018
Hillson O, Gonzalez S and Rallis C (2018). Prospects of Pharmacological Interventions to Organismal Aging. De Gruyter BioMolecular Concepts vol. 9, (1) 200-215. Atkinson SR, Marguerat S, Bitton DA, Rodríguez-López M, Rallis C, Lemay J-F, Cotobal C, Malecki M, Smialowski P, Mata J, Korber P, Bachand F and Bähler J (2018). Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast. Cold Spring Harbor Laboratory RNA vol. 24, (9) 1195-1213. Ellis DA, Mustonen V, Rodríguez-López M, Rallis C, Malecki M, Jeffares DC and Bähler J (2018). Uncovering Natural Longevity Alleles from Intercrossed Pools of Aging Fission Yeast Cells. Oxford University Press (OUP) Genetics vol. 210, (2) 733-744. 2017
Hoyos-Manchado R, Reyes-Martín F, Rallis C, Gamero-Estévez E, Rodríguez-Gómez P, Quintero-Blanco J, Bähler J, Jiménez J and Tallada VA (2017). RNA metabolism is the primary target of formamide in vivo. Springer Nature Scientific Reports vol. 7, (1) Rallis C, Townsend S and Bähler J (2017). Erratum: Corrigendum: Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Springer Nature Scientific Reports vol. 7, (1) Rallis C, Townsend S and Bähler J (2017). Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Springer Nature Scientific Reports vol. 7, (1) Jeffares DC, Jolly C, Hoti M, Speed D, Shaw L, Rallis C, Balloux F, Dessimoz C, Bähler J and Sedlazeck FJ (2017). Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast. Springer Nature Nature Communications vol. 8, (1) Gonzalez S and Rallis C (2017). The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth. Front Cell Dev Biol vol. 5, 2016
Malecki M, Bitton DA, Rodríguez-López M, Rallis C, Calavia NG, Smith GC and Bähler J (2016). Functional and regulatory profiling of energy metabolism in fission yeast. Springer Nature Genome Biology vol. 17, (1) Brault A, Rallis C, Normant V, Garant J-M, Bähler J and Labbé S (2016). Php4 Is a Key Player for Iron Economy in Meiotic and Sporulating Cells. Oxford University Press (OUP) G3: Genes, Genomes, Genetics vol. 6, (10) 3077-3095. Bischof L, Pevorovsk M, Rallis C, Jeffares DC, Arzhaeva Y and Bhler J (2016). Spotsizer: High-throughput quantitative analysis of microbial growth. Taylor & Francis BioTechniques vol. 61, (4) 191-201. Vishwanatha A, Rallis C, Subramanyaswamy SB, D'Souza CJM, Bähler J and Schweingruber ME (2016). Identification of nuclear genes affecting 2-Deoxyglucose resistance in Schizosaccharomyces pombe. Oxford University Press (OUP) FEMS Yeast Research vol. 16, (6) Tomalin LE, Day AM, Underwood ZE, Smith GR, Pezze PD, Rallis C, Patel W, Dickinson BC, Bähler J, Brewer TF, Chang CJ-L, Shanley DP and Veal EA (2016). Increasing extracellular H2O2 produces a bi-phasic response in intracellular H2O2, with peroxiredoxin hyperoxidation only triggered once the cellular H2O2-buffering capacity is overwhelmed. Elsevier Free Radical Biology and Medicine vol. 95, 333-348. 2015
Bond ME, Brown R, Rallis C, Bähler J and Mole SE (2015). A central role for TOR signalling in a yeast model for juvenile CLN3 disease. Shared Science Publishers OG Microbial Cell vol. 2, (12) Rallis C and Bähler J (2015). Cell-based screens and phenomics with fission yeast. Taylor & Francis Critical Reviews in Biochemistry and Molecular Biology vol. 51, (2) 86-95. Bitton DA, Atkinson SR, Rallis C, Smith GC, Ellis DA, Chen YYC, Malecki M, Codlin S, Lemay J-F, Cotobal C, Bachand F, Marguerat S, Mata J and Bähler J (2015). Widespread exon skipping triggers degradation by nuclear RNA surveillance in fission yeast. Cold Spring Harbor Laboratory Genome Research vol. 25, (6) 884-896. Jeffares DC, Rallis C, Rieux A, Speed D, Převorovský M, Mourier T, Marsellach FX, Iqbal Z, Lau W, Cheng TMK, Pracana R, Mülleder M, Lawson JLD, Chessel A, Bala S, Hellenthal G, O'Fallon B, Keane T, Simpson JT, Bischof L, Tomiczek B, Bitton DA, Sideri T, Codlin S, Hellberg JEEU, van Trigt L, Jeffery L, Li J-J, Atkinson S and Thodberg M (2015). The genomic and phenotypic diversity of Schizosaccharomyces pombe. Springer Nature Nature Genetics vol. 47, (3) 235-241. Sideri T, Rallis C, Bitton DA, Lages BM, Suo F, Rodríguez-López M, Du L-L and Bähler J (2015). Parallel Profiling of Fission Yeast Deletion Mutants for Proliferation and for Lifespan During Long-Term Quiescence. Oxford University Press (OUP) G3: Genes, Genomes, Genetics vol. 5, (1) 145-155. 2014
Sofola-Adesakin O, Castillo-Quan JI, Rallis C, Tain LS, Bjedov I, Rogers I, Li L, Martinez P, Khericha M, Cabecinha M, Bähler J and Partridge L (2014). Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease. Frontiers Frontiers in Aging Neuroscience vol. 6, Bitton DA, Rallis C, Jeffares DC, Smith GC, Chen YYC, Codlin S, Marguerat S and Bähler J (2014). LaSSO, a strategy for genome-wide mapping of intronic lariats and branch points using RNA-seq. Cold Spring Harbor Laboratory Genome Research vol. 24, (7) 1169-1179. Rallis C, López-Maury L, Georgescu T, Pancaldi V and Bähler J (2014). Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth. The Company of Biologists Biology Open vol. 3, (2) 161-171. 2013
Rallis C and Bähler J (2013). Inhibition of TORC1 signaling and increased lifespan: gained in translation? Impact Journals Aging vol. 5, (5) 335-336. Rallis C, Codlin S and Bähler J (2013). TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast. Wiley Aging Cell vol. 12, (4) 563-573. 2012
Pancaldi V, Saraç ÖS, Rallis C, McLean JR, Převorovský M, Gould K, Beyer A and Bähler J (2012). Predicting the Fission Yeast Protein Interaction Network. Oxford University Press (OUP) G3: Genes, Genomes, Genetics vol. 2, (4) 453-467. 2010
Rallis C, Pinchin SM and Ish-Horowicz D (2010). Cell-autonomous integrin control of Wnt and Notch signalling during somitogenesis. The Company of Biologists Development vol. 137, (21) 3591-3601. Maydan M, McDonald PC, Sanghera J, Yan J, Rallis C, Pinchin S, Hannigan GE, Foster LJ, Ish-Horowicz D, Walsh MP and Dedhar S (2010). Integrin-Linked Kinase Is a Functional Mn2+-Dependent Protein Kinase that Regulates Glycogen Synthase Kinase-3β (GSK-3β) Phosphorylation. Public Library of Science (PLoS) PLOS ONE vol. 5, (8) 2005
Rallis C, Del Buono J and Logan MPO (2005). Tbx3 can alter limb position along the rostrocaudal axis of the developing embryo. The Company of Biologists Development vol. 132, (8) 1961-1970. 2003
Rallis C, Bruneau BG, Del Buono J, Seidman CE, Seidman JG, Nissim S, Tabin CJ and Logan MPO (2003). Tbx5 is required for forelimb bud formation and continued outgrowth. The Company of Biologists Development vol. 130, (12) 2741-2751. 2001
Rallis C, Stamataki D, Pontikakis S, Mankoo BS and Karagogeos D (2001). Isolation of the avian homologue of the homeobox gene Mox2 and analysis of its expression pattern in developing somites and limbs. Elsevier Cells and Development vol. 104, (1-2) 121-124. Grants
Integrating cellular space and time: inteplays between subcellular organisation and lifespan-GRANT TRANSFERCharalampos (Babis) Rallis
£269,451 BBSRC Biotechnology and Biological Sciences Research Council (01-09-2023 - 14-04-2026)
Mechanisms of uncoupling cellular growth from mTOR pathway activity - GRANT TRANSFERCharalampos (Babis) Rallis
£292,263 MRC Medical Research Council (01-09-2023 - 13-02-2025)