Dr Caroline Roney

Caroline Roney

Lecturer in Computational Medicine

School of Engineering & Materials Science
Queen Mary University of London

Research

Computational Medicine, Cardiac Arrhythmia, Biophysical Modelling, Machine learning, Signal Processing, Image Processing

Cardiovascular Models

Interests

Interested in the integration of AI and machine learning techniques with in vitro organ-chip models with a particular focus on cardiovascular applications.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2024

Vector Field Heterogeneity as a Novel Omnipolar Mapping Metric for Functional Substrate Characterisation in Scar-related Ventricular Tachycardias
Tonko J, Ruipérez-Campillo S, Cabero-Vidal G, Cabrera-Borrego E, Roney C, Jiminez J, Roig JM, Castells-Ramon F and Lambiase P
Heart Rhythm, Elsevier 
01-11-2024
An in-silico comparison of anatomical and substrate based AF ablation using electro and optical flow mapping
Jaffery OA, Zolotarev A, Barera CE, Rodero C, Niederer S, Slabaugh G, Good WW and Roney CH
European Heart Journal, Oxford University Press (Oup) vol. 45 (Supplement_1), ehae666.579-ehae666.579.  
28-10-2024
The effect of fixed and functional remodelling on conduction velocity, wavefront propagation, and rotational activity formation in atrial fibrillation
Honarbakhsh S, Horrach CV, Lambiase PD, Roney C and Hunter RJ
Ep Europace, Oxford University Press (Oup) vol. 26 (10) 
16-09-2024
Autonomic modulation impacts conduction velocity dynamics and wavefront propagation in the left atrium
Honarbakhsh S, Roney C, Horrach CV, Lambiase PD and Hunter RJ
Ep Europace, Oxford University Press (Oup) vol. 26 (9) 
30-08-2024
Observable Atrial and Ventricular Fibrillation Episode Durations Are Conformant With a Power Law Based on System Size and Spatial Synchronization
Dharmaprani D, Tiver K, Shahrbabaki SS, Jenkins EV, Chapman D, Strong C, Quah JX, Tonchev I, O’Loughlin L, Mitchell L, Tung M, Ahmad W, Stoyanov N, Aguilar M, Niederer SA, Roney CH, Nash MP, Clayton RH, Nattel S and Ganesan AN
Circulation Arrhythmia and Electrophysiology, Wolters Kluwer vol. 17 (7) 
28-06-2024
Omnipolar conduction velocity mapping for ventricular substrate characterization: Impact of CV estimation method and EGM type on in vivo conduction velocity measurements
Tonko JB, Ehnesh M, Vigmond E, Chow A, Roney C and Lambiase PD
Heart Rhythm, Elsevier vol. 21 (12), 2499-2508.  
06-06-2024
Peak frequency can be effectively used to characterize atrial remodelling in atrial fibrillation
Al-Aidarous S, Horrach CV, Roney C, Butcher C, Hunter R and Honarbakhsh S
Ep Europace, Oxford University Press (Oup) vol. 26 (Supplement_1) 
24-05-2024
Effects of different types of fibrotic remodelling in areas of low voltage on atrial fibrillation dynamics: an in-silico study
Horrach CV, Jaffery OA, Hunter RJ, Honarbakhsh S and Roney C
Ep Europace, Oxford University Press (Oup) vol. 26 (Supplement_1) 
24-05-2024
Enhancing OpenEP: atrial conduction velocity and conduction velocity heterogeneity quantification through EP Workbench
Vigneswaran V, Gharaviri AG, Klis MK, Bodagh NB, Sim IS, Roney CR, Kotadia IK, Niederer SN, Neill MOO and Williams SW
Ep Europace, Oxford University Press (Oup) vol. 26 (Supplement_1) 
24-05-2024
A Review of Personalised Cardiac Computational Modelling Using Electroanatomical Mapping Data
Jaffery OA, Melki L, Slabaugh G, Good WW and Roney CH
Arrhythmia & Electrophysiology Review, Radcliffe Cardiology vol. 13 
20-05-2024
PO-05-119 PEAK FREQUENCY CAN BE EFFECTIVELY USED TO CHARACTERIZE ATRIAL REMODELING IN ATRIAL FIBRILLATION
Al-Aidarous S, Horrach CV, Roney CH, Butcher C, Hunter RJ and Honarbakhsh S
Heart Rhythm, Elsevier vol. 21 (5), s529-s530.  
01-05-2024
PO-06-114 REDEFINING ATRIAL SUBSTRATE ASSESSMENT IN THE OMNIPOLAR MAPPING ERA
Valli H, Ehnesh M, Chen Z, Hussain W, Jones DG, Wong T, Roney CH and Haldar S
Heart Rhythm, Elsevier vol. 21 (5) 
01-05-2024
PO-05-033 PATIENT-SPECIFIC BIATRIAL MODELLING FRAMEWORK FOR PREDICTING ATRIAL FIBRILLATION OUTCOMES
Misghina SB, Solis-Lemus JA, Lopez-Barrera CE, Rauseo E, Vigmond EJ, Niederer SA, Aung N, Munroe PB, Petersen SE and Roney CH
Heart Rhythm, Elsevier vol. 21 (5), s565-s566.  
01-05-2024
PO-05-025 ANATOMICAL AND PHYSIOLOGICAL FEATURES IMPROVE AF ABLATION OUTCOME PREDICTION: A COMBINED DEEP LEARNING AND IN-SILICO APPROACH
Zolotarev A, Rodero C, Narayan SM, Vigmond EJ, Plank G, Niederer SA and Roney CH
Heart Rhythm, Elsevier vol. 21 (5), s561-s562.  
01-05-2024
PO-05-031 THE DETERMINATION OF ABLATION TARGETS IN PATIENT-SPECIFIC ATRIAL MODELS IS INFLUENCED BY THE DATA USED FOR CALIBRATION.
Ehnesh M, Valli H, Zolotarev A, Jaffery OA, Barrera CL, Vigmond EJ, Haldar S and Roney CH
Heart Rhythm, Elsevier vol. 21 (5), s564-s565.  
01-05-2024
A three-dimensional left atrial motion estimation from retrospective gated computed tomography: application in heart failure patients with atrial fibrillation
Sillett C, Razeghi O, Lee AWC, Lemus JAS, Roney C, Mannina C, de Vere F, Ananthan K, Ennis DB, Haberland U, Xu H, Young A, Rinaldi CA, Rajani R and Niederer SA
Frontiers in Cardiovascular Medicine, Frontiers vol. 11 
26-03-2024
Does spatiotemporal dispersion indicate a patient-unique fingerprint or a generic characteristic of persistent atrial fibrillation?
Roney C and Honarbakhsh S
Heart Rhythm, Elsevier vol. 21 (5), 553-554.  
01-02-2024
Spatial and temporal relationship between focal and rotational activations and their relationship to structural remodeling in patients with persistent atrial fibrillation
Honarbakhsh S, Roney C, Wharmby A, Vidal Horrach C and Hunter RJ
Heart Rhythm, Elsevier vol. 21 (6), 752-761.  
28-01-2024
High Prevalence of New Clinically Significant Findings in Patients With Embolic Stroke of Unknown Source Evaluated by Cardiac Magnetic Resonance Imaging
Kotadia ID, O'Dowling R, Aboagye A, Crawley RJ, Bodagh N, Gharaviri A, O'Hare D, Solis‐Lemus JA, Roney CH, Sim I, Ramsey D, Newby D, Chiribiri A, Plein S, Sztriha L, Scott P, Masci P, Harrison J, Williams MC, Birns J, Somerville P, Bhalla A, Niederer S, O'Neill M and Williams SE
Journal of The American Heart Association, Wolters Kluwer vol. 13 (3) 
19-01-2024
Misclassification Loss for Segmentation of the Aortic Vessel Tree
Khan A, Asad M, Zolotarev A, Roney C, Mathur A, Benning M and Slabaugh G
In Segmentation of The Aorta. Towards The Automatic Segmentation, Modeling, and Meshing of The Aortic Vessel Tree From Multicenter, Springer Nature 67-79.  
01-01-2024

2023

Constructing bilayer and volumetric atrial models at scale
Roney CH, Lemus JAS, Barrera CL, Zolotarev A, Ulgen O, Kerfoot E, Bevis L, Misghina S, Horrach CV, Jaffery OA, Ehnesh M, Rodero C, Dharmaprani D, Ríos-Muñoz GR, Ganesan A, Good WW, Neic A, Plank G, Hopman LHGA, Götte MJW, Honarbakhsh S, Narayan SM, Vigmond E and Niederer S
Interface Focus, The Royal Society vol. 13 (6), 20230038-20230038.  
15-12-2023
A Semi-automatic Pipeline for Generation of Large Cohorts of Four-Chamber Heart Meshes
Strocchi M, Rodero C, Roney CH, Mendonca Costa C, Plank G, Lamata P and Niederer SA
Methods in Molecular Biology, Springer Nature vol. 2735, 117-127.  
02-12-2023
Deep neural network architectures for cardiac image segmentation
El-Taraboulsi J, Cabrera CP, Roney C and Aung N
Artificial Intelligence in The Life Sciences, Elsevier vol. 4 
01-12-2023
Abstract 13321: Novel Regional Analysis of Left Atrial Strain From Computed Tomography Separates Patients With Persistent versus Paroxysmal Atrial Fibrillation
Sillett C, Razeghi O, Lee A, Lemus JAS, Roney C, Ganesan P, Feng R, Chubb H, NIEMAN K, Rogers AJ, Rajani R, Narayan SM and Niederer SA
Circulation, Wolters Kluwer vol. 148 (Suppl_1), a13321-a13321.  
07-11-2023
AF and in-hospital mortality in COVID-19 patients
Kotadia ID, Dias M, Roney C, Parker RA, O’Dowling R, Bodagh N, Lemus-Solis J-A, O’Hare D, Sim I, Newby D, Niederer S, Birns J, Sommerville P, Bhalla A, O’Neill M and Williams SE
Heart Rhythm O2, Elsevier vol. 4 (11), 700-707.  
16-10-2023
A personalized real-time virtual model of whole heart electrophysiology
Gillette K, Gsell MAF, Strocchi M, Grandits T, Neic A, Manninger M, Scherr D, Roney CH, Prassl AJ, Augustin CM, Vigmond EJ and Plank G
Ep Europace, Oxford University Press vol. 25 (Suppl 1), euad122.541-euad122.541.  
24-05-2023
In silico biatrial fibrosis ablation improves atrial fibrillation outcome
Roney C, Alonso JSL, Sim I, Ulgen O, Rodero C, Strocchi M, Kotadia I, Honarbakhsh S, Narayan S, Plank G, Vigmond E, Williams SE and Niederer S
Ep Europace, Oxford University Press (Oup) vol. 25 (Supplement_1) 
24-05-2023
Atrial fibrillation and in-hospital mortality in Covid-19 patients
Kotadia I, Dias M, Roney C, Parker RA, O'dowling R, O'hare D, Solis-Lemus JA, Sim I, Birns J, Sommerville P, Bhalla A, Newby D, Niederer S, O'neill M and Williams SE
Ep Europace, Oxford University Press (Oup) vol. 25 (Supplement_1) 
24-05-2023
In Atrial Fibrillation, Omnipolar Voltage Maps More Accurately Delineate Scar Than Bipolar Voltage Maps
Butcher C, Roney C, Wharmby A, Ahluwalia N, Chow A, Lambiase PD, Hunter RJ and Honarbakhsh S
Jacc Clinical Electrophysiology, Elsevier vol. 9 (8), 1500-1512.  
18-05-2023
Evaluation of an open-source pipeline to create patient-specific left atrial models: A reproducibility study
Solís-Lemus JA, Baptiste T, Barrows R, Sillett C, Gharaviri A, Raffaele G, Razeghi O, Strocchi M, Sim I, Kotadia I, Bodagh N, O’Hare D, O’Neill M, Williams SE, Roney C and Niederer S
Computers in Biology and Medicine, Elsevier vol. 162, 107009-107009.  
16-05-2023
PO-03-103 OMNIPOLAR VOLTAGE MAPPING DURING AF EFFECTIVELY OVERCOMES THE IMPACT WAVEFRONT COLLISION AND FRACTIONATION HAS ON BIPOLAR VOLTAGE MAPS AND MORE EFFECTIVELY IDENTIFIES SITES OF PV RECONNECTION AT PREVIOUS WIDE AREA CIRCUMFERENTIAL LINES COMPARED TO BIPOLAR VOLTAGE MAPS
Butcher C, Roney CH, Ahluwalia N, Wharmby AL, Chow AW, Lambiase PD, Hunter RJ and Honarbakhsh S
Heart Rhythm, Elsevier vol. 20 (5) 
01-05-2023
PO-01-095 REGIONAL DIFFERENCES IN ATRIAL FIBER STRAINS IN HEART FAILURE PATIENTS WITH AND WITHOUT ATRIAL FIBRILLATION
Sillett C, Razeghi O, Lee AW, Solis-Lemus JA, Roney CH, Ennis D, Rinaldi CA, Rajani R and Niederer SA
Heart Rhythm, Elsevier vol. 20 (5) 
01-05-2023
PO-01-215 ATRIAL FIBRILLATION OUTCOME IS IMPROVED BY BIATRIAL SUBSTRATE ABLATION IN A LARGE VIRTUAL TRIAL
Roney CH, Solis-Lemus JA, Honarbakhsh S, Sim I, Rodero C, Strocchi M, Kotadia I, Narayan SM, Plank G, Vigmond EJ, Williams SE and Niederer SA
Heart Rhythm, Elsevier vol. 20 (5), s164-s165.  
01-05-2023
PO-02-172 CONDUCTION VELOCITY AND CONDUCTION VELOCITY DYNAMICS IN THE LEFT ATRIUM ARE IMPACTED BY STRUCTURAL AND AUTONOMIC MODULATION AND SITES OF CONDUCTION VELOCITY HETEROGENEITY CORRELATE TO RE-ENTRY ACTIVITY IN ATRIAL FIBRILLATION
Honarbakhsh S, Roney CH, Wharmby AL, Abbass H, Whittaker-Axon S, Lambiase PD and Hunter RJ
Heart Rhythm, Elsevier vol. 20 (5), s300-s301.  
01-05-2023
Atrial fibrillation ablation outcome prediction with a machine learning fusion framework incorporating cardiac computed tomography
Razeghi O, Kapoor R, Alhusseini MI, Fazal M, Tang S, Roney CH, Rogers AJ, Lee A, Wang PJ, Clopton P, Rubin DL, Narayan SM, Niederer S and Baykaner T
Journal of Cardiovascular Electrophysiology, Wiley vol. 34 (5), 1164-1174.  
27-04-2023
Quantifying the impact of shape uncertainty on predicted arrhythmias
Corrado C, Roney CH, Razeghi O, Lemus JAS, Coveney S, Sim I, Williams SE, O'Neill MD, Wilkinson RD, Clayton RH and Niederer SA
Computers in Biology and Medicine, Elsevier vol. 153, 106528-106528.  
03-01-2023
Effect of Varying Pericardial Boundary Conditions on Whole Heart Function: A Computational Study
Ghebryal J, Rodero C, Barrows RK, Strocchi M, Roney CH, Augustin CM, Plank G and Niederer SA
In Functional Imaging and Modeling of The Heart, Springer Nature 545-554.  
01-01-2023

2022

Fiber Organization Has Little Effect on Electrical Activation Patterns During Focal Arrhythmias in the Left Atrium
He J, Pertsov AM, Cherry EM, Fenton FH, Roney CH, Niederer SA, Zang Z and Mangharam R
Ieee Transactions On Biomedical Engineering, Institute of Electrical and Electronics Engineers vol. 70 (5), 1611-1621.  
18-11-2022
Calibrating cardiac electrophysiology models using latent Gaussian processes on atrial manifolds
Coveney S, Roney CH, Corrado C, Wilkinson RD, Oakley JE, Niederer SA and Clayton RH
Scientific Reports, Nature Research vol. 12 (1), 16572-16572.  
04-10-2022
A personalized real-time virtual model of whole heart electrophysiology
Gillette K, Gsell MAF, Strocchi M, Grandits T, Neic A, Manninger M, Scherr D, Roney CH, Prassl AJ, Augustin CM, Vigmond EJ and Plank G
Frontiers in Physiology, Frontiers Media vol. 13, 907190-907190.  
23-09-2022
The inspection paradox: An important consideration in the evaluation of rotor lifetimes in cardiac fibrillation
Jenkins EV, Dharmaprani D, Schopp M, Quah JX, Tiver K, Mitchell L, Xiong F, Aguilar M, Pope K, Akar FG, Roney CH, Niederer SA, Nattel S, Nash MP, Clayton RH and Ganesan AN
Frontiers in Physiology, Frontiers Media vol. 13, 920788-920788.  
06-09-2022
Atrial conduction velocity mapping: clinical tools, algorithms and approaches for understanding the arrhythmogenic substrate
Coveney S, Cantwell C and Roney C
Medical & Biological Engineering & Computing, Springer Nature vol. 60 (9), 2463-2478.  
22-07-2022
OpenEP-Py and OpenEP-GUI: An interactive platform for the visualisation and analysis of clinical and simulated cardiac electrophysiology data
Smith P, Bishop M, Rajan J, Kerfoot E, Sim I, Kotadia I, O’hare D, Fitzpatrick N, Grubb NR, Corrado C, Connelly A, Roney C, Niederer S, O’neill M and Williams SE
Ep Europace, Oxford University Press (Oup) vol. 24 (Supplement_1) 
19-05-2022
Interpolation of electrophysiology parameters using OpenEP: technology development and clinical application
Williams S, Roney C, Connolly A, Smith P, Bishop M, Niederer S, Whitaker J, Corrado C, Kotadia I, O’hare D, Fitzpatrick N, Sim I and O’neill M
Ep Europace, Oxford University Press (Oup) vol. 24 (Supplement_1) 
19-05-2022
Atrial tissue characterisation using electroanatomic voltage mapping and cardiac magnetic resonance imaging
Sim I, Razeghi O, Lemus JS, Mukherjee R, O’hare D, O’neill L, Kotadia I, Roney C, Wright M, Chiribiri A, Niederer S, O’neill M and Williams
Ep Europace, Oxford University Press (Oup) vol. 24 (Supplement_1) 
19-05-2022
PO-616-05 THE INSPECTION PARADOX: AN IMPORTANT CONSIDERATION IN THE EVALUATION OF ROTOR LIFETIMES IN CARDIAC FIBRILLATION
Jenkins E, Dharmaprani D, Schopp M, Quah J, Tiver K, Xiong F, Aguilar M, Akar FG, Roney CH, Niederer SA, Nattel S, Nash MP, Clayton RH and Ganesan AN
Heart Rhythm, Elsevier vol. 19 (5), s112-s112.  
28-04-2022
PO-664-05 LOCAL AREA STRAINS FROM RETROSPECTIVE GATED COMPUTED TOMOGRAPHY IMAGING TO DETECT ATRIAL FIBRILLATION
Sillett C, Razeghi O, Strocchi M, Roney CH, O'Brien H, Ennis D, Haberland U, Rajani R, Rinaldi CA and Niederer SA
Heart Rhythm, Elsevier vol. 19 (5), s297-s298.  
28-04-2022
Detection of focal source and arrhythmogenic substrate from body surface potentials to guide atrial fibrillation ablation
Feng Y, Roney CH, Bayer JD, Niederer SA, Hocini M and Vigmond EJ
Plos Computational Biology, Public Library of Science (Plos) vol. 18 (3) 
21-03-2022
Predicting Atrial Fibrillation Recurrence by Combining Population Data and Virtual Cohorts of Patient-Specific Left Atrial Models
Roney CH, Sim I, Yu J, Beach M, Mehta A, Solis-Lemus JA, Kotadia I, Whitaker J, Corrado C, Razeghi O, Vigmond E, Narayan SM, O’Neill M, Williams SE and Niederer SA
Circulation Arrhythmia and Electrophysiology, Wolters Kluwer vol. 15 (2) 
28-01-2022
Atrial CARdiac Magnetic resonance imaging in patients with embolic stroke of unknown source without documented Atrial Fibrillation (CARM-AF): Study design and clinical protocol
Kotadia ID, O’Dowling R, Aboagye A, Sim I, O’Hare D, Lemus-Solis J-A, Roney CH, Dweck M, Chiribiri A, Plein S, Sztriha L, Scott P, Harrison J, Ramsay D, Birns J, Somerville P, Bhalla A, Niederer S, O’Neill M and Williams SE
Heart Rhythm O2, Elsevier vol. 3 (2), 196-203.  
20-01-2022
The Inspection Paradox: An Important Consideration in the Evaluation of Rotor Lifetimes in Cardiac Fibrillation
Jenkins E, Dharmaprani D, Schopp M, Quah JX, Tiver K, Mitchell L, Xiong F, Aguilar M, Pope K, Akar F, Roney C, Niederer S, Nattel S, Nash M, Clayton R and Ganesan A
Heart Lung and Circulation, Elsevier vol. 31, s133-s134.  
01-01-2022

2021

Applications of multimodality imaging for left atrial catheter ablation
Roney CH, Sillett C, Whitaker J, Lemus JAS, Sim I, Kotadia I, O'Neill M, Williams SE and Niederer SA
European Heart Journal - Cardiovascular Imaging, Oxford University Press (Oup) vol. 23 (1), 31-41.  
08-11-2021
Late Gadolinium Enhancement Cardiovascular Magnetic Resonance Assessment of Substrate for Ventricular Tachycardia With Hemodynamic Compromise
Whitaker J, Neji R, Kim S, Connolly A, Aubriot T, Calvo JJ, Karim R, Roney CH, Murfin B, Richardson C, Morgan S, Ismail TF, Harrison J, de Vos J, Aalders MCG, Williams SE, Mukherjee R, O'Neill L, Chubb H, Tschabrunn C, Anter E, Camporota L, Niederer S, Roujol S, Bishop MJ, Wright M, Silberbauer J, Razavi R and O'Neill M
Frontiers in Cardiovascular Medicine, Frontiers vol. 8 
26-10-2021
Time-Averaged Wavefront Analysis Demonstrates Preferential Pathways of Atrial Fibrillation, Predicting Pulmonary Vein Isolation Acute Response
Roney CH, Child N, Porter B, Sim I, Whitaker J, Clayton RH, Laughner JI, Shuros A, Neuzil P, Williams SE, Razavi RS, O'Neill M, Rinaldi CA, Taggart P, Wright M, Gill JS and Niederer SA
Frontiers in Physiology, Frontiers vol. 12 
27-09-2021
B-PO02-137 OPEN-SOURCE PLATFORM FOR ANALYSIS OF FIBROSIS BEFORE AND AFTER A PULMONARY VEIN ISOLATION PROCEDURE
Solis-Lemus JA, Roney CH, Razeghi O, Sim I, Kotadia I, Mukherjee R, Williams SE, O'Neill M and Niederer SA
Heart Rhythm, Elsevier vol. 18 (8) 
01-08-2021
B-PO03-022 INTEGRATING ATRIAL CARDIAC MAGNETIC RESONANCE IMAGING AND ELECTROANATOMIC MAPPING DATA USING UNIVERSAL ATRIAL CO-ORDINATES AND OPENEP (AN OPEN-SOURCE FRAMEWORK FOR ELECTROPHYSIOLOGY RESEARCH)
Williams SE, Roney CH, Sim I, Kotadia I, Solis-Lemus JA, Razeghi O, Corrado C, Wright MJ, Niederer SA and O'Neill MD
Heart Rhythm, Elsevier vol. 18 (8) 
01-08-2021
B-PO03-096 DIELECTRIC IMAGING ACCURATELY MEASURES REGIONAL CARDIAC CHAMBER WALL THICKNESS - AN IN VIVO STUDY
Kotadia I, Williams ISM, Roney CH, Solis-Lemus J, Razeghi O, Daniel C, Clutton SGE, Grant RGL, Proudfoot JNC, Reisner Y, Harks E, Pilmeyer A, Welsh AKS, Whitaker J, Wright MJ, Niederer SA, O'Neill M and Williams SE
Heart Rhythm, Elsevier vol. 18 (8), s227-s228.  
27-07-2021
B-PO05-007 RAPID AND ROBUST MAPPING OF CLINICAL DATA ON PERSONALIZED VOLUMETRIC ATRIAL GEOMETRIES
Ali SY, Millare B, Bradley R, Ali RL, Boyle PM, Salvador M, Fedele M, Aronis KN, Paliwal N, Prakosa A, Roney CH, Vigmond EJ, Niederer SA and Trayanova NA
Heart Rhythm, Elsevier vol. 18 (8), s374-s374.  
27-07-2021
B-PO05-012 PREDICTING ATRIAL FIBRILLATION RECURRENCE BY COMBINING POPULATION DATA & PATIENT-SPECIFIC MODELING
Roney CH, Sim I, Yu J, Beach M, Mehta A, Solis-Lemus J, Kotadia I, Whitaker J, Razeghi O, Vigmond EJ, Narayan SM, O'Neill MD, Williams SE and Niederer SA
Heart Rhythm, Elsevier vol. 18 (8), s375-s376.  
27-07-2021
Computational modeling identifies embolic stroke of undetermined source patients with potential arrhythmic substrate
Bifulco SF, Scott GD, Sarairah S, Birjandian Z, Roney CH, Niederer SA, Mahnkopf C, Kuhnlein P, Mitlacher M, Tirschwell D, Longstreth W, Akoum N and Boyle PM
Elife, Elife vol. 10 
04-05-2021
OpenEP: A Cross-Platform Electroanatomic Mapping Data Format and Analysis Platform for Electrophysiology Research
Williams SE, Roney CH, Connolly A, Sim I, Whitaker J, O’Hare D, Kotadia I, O’Neill L, Corrado C, Bishop M, Niederer SA, Wright M, O’Neill M and Linton NWF
Frontiers in Physiology, Frontiers vol. 12 
26-02-2021
Using machine learning to identify local cellular properties that support re-entrant activation in patient-specific models of atrial fibrillation
Corrado C, Williams S, Roney C, Plank G, O’Neill M and Niederer S
Ep Europace, Oxford University Press (Oup) vol. 23 (Supplement_1), i12-i20.  
12-01-2021
Anisotropic cardiac conduction
Kotadia I, Whitaker J, Roney C, Niederer S, O’Neill M, Bishop M and Wright M
Arrhythmia and Electrophysiology Review vol. 9 
01-01-2021

2020

Fully Automatic Atrial Fibrosis Assessment Using a Multilabel Convolutional Neural Network
Razeghi O, Sim I, Roney CH, Karim R, Chubb H, Whitaker J, O’Neill L, Mukherjee R, Wright M, O’Neill M, Williams SE and Niederer S
Circulation: Cardiovascular Imaging, American Heart Association vol. 13 (12), e011512-e011512.  
15-12-2020
Clinical translation of patient-specific organ level cardiac models
Costa CM, Roney C, Strocchi M, Razeghi O and Niederer S
In Modeling and Simulating Cardiac Electrical Activity, Iop Publishing 
01-12-2020
Abstract 14899: Personalized Computational Modeling Identifies Embolic Stroke of Undetermined Source Patients With Potential Arrhythmic Substrate
Bifulco S, Scott GD, Sarairah S, Birjandian Z, Roney C, Niederer SA, Mahnkopf C, Kuhnlein P, Mitlacher M, Tirschwell D, Akoum NW and Boyle PM
Circulation, Wolters Kluwer vol. 142 (Suppl_3) 
17-11-2020
Left atrial enhancement correlates with myocardial conduction velocity in patients with persistent atrial fibrillation
Ali RL, Qureshi NA, Liverani S, Roney CH, Kim S, Lim PB, Tweedy JH, Cantwell CD and Peters NS
Frontiers in Physiology, Frontiers Media 
12-11-2020
CemrgApp: An interactive medical imaging application with image processing, computer vision, and machine learning toolkits for cardiovascular research
Razeghi O, Solís-Lemus JA, Lee AWC, Karim R, Corrado C, Roney CH, de Vecchi A and Niederer SA
Softwarex, Elsevier vol. 12 
01-07-2020
P920Understanding arrhythmia mechanisms in patients with atrial septal defects
O"neill L, Sim I, O"hare D, Whitaker J, Mukherjee R, Roney C, Razeghi O, Niederer S, Harith A, Rosenthal E, Jones M, Wright M, Frigiola A, O"neill M and Williams S
Ep Europace, Oxford University Press (Oup) vol. 22 (Supplement_1) 
01-06-2020
Constructing a Human Atrial Fibre Atlas
Roney CH, Bendikas R, Pashakhanloo F, Corrado C, Vigmond EJ, McVeigh ER, Trayanova NA and Niederer SA
Annals of Biomedical Engineering, Springer Nature vol. 49 (1), 233-250.  
26-05-2020
An audit of uncertainty in multi-scale cardiac electrophysiology models
Clayton RH, Aboelkassem Y, Cantwell CD, Corrado C, Delhaas T, Huberts W, Lei CL, Ni H, Panfilov AV, Roney C and dos Santos RW
Philosophical Transactions of The Royal Society a Mathematical Physical and Engineering Sciences, The Royal Society vol. 378 (2173) 
25-05-2020
Creation and application of virtual patient cohorts of heart models
Niederer SA, Aboelkassem Y, Cantwell CD, Corrado C, Coveney S, Cherry EM, Delhaas T, Fenton FH, Panfilov AV, Pathmanathan P, Plank G, Riabiz M, Roney CH, dos Santos RW and Wang L
Philosophical Transactions of The Royal Society a Mathematical Physical and Engineering Sciences, The Royal Society vol. 378 (2173) 
25-05-2020
Gaussian process manifold interpolation for probabilistic atrial activation maps and uncertain conduction velocity
Coveney S, Corrado C, Roney CH, OHare D, Williams SE, ONeill MD, Niederer SA, Clayton RH, Oakley JE and Wilkinson RD
Philosophical Transactions of The Royal Society a Mathematical Physical and Engineering Sciences, The Royal Society vol. 378 (2173) 
25-05-2020
Ventricular fibrillation mechanism and global fibrillatory organization are determined by gap junction coupling and fibrosis pattern
Handa BS, Li X, Baxan N, Roney CH, Shchendrygina A, Mansfield CA, Jabbour RJ, Pitcher DS, Chowdhury RA, Peters NS and Ng FS
Cardiovascular Research, Oxford University Press (Oup) vol. 117 (4), 1078-1090.  
13-05-2020
Challenges Associated with Interpreting Mechanisms of AF
Roney CH, Wit AL and Peters NS
Arrhythmia & Electrophysiology Review, Radcliffe Cardiology vol. 8 (4), 273-284.  
11-02-2020
Using cardiac ionic cell models to interpret clinical data
Corrado C, Avezzù A, Lee AWC, Mendoca Costa C, Roney CH, Strocchi M, Bishop M and Niederer SA
Wiley Interdisciplinary Reviews: Systems Biology and Medicine 
01-01-2020
In silico Comparison of Left Atrial Ablation Techniques That Target the Anatomical, Structural, and Electrical Substrates of Atrial Fibrillation
Roney CH, Beach ML, Mehta AM, Sim I, Corrado C, Bendikas R, Solis-Lemus JA, Razeghi O, Whitaker J, O’Neill L, Plank G, Vigmond E, Williams SE, O’Neill MD and Niederer SA
Frontiers in Physiology vol. 11 
01-01-2020
Probabilistic Interpolation of Uncertain Local Activation Times on Human Atrial Manifolds
Coveney S, Clayton RH, Corrado C, Roney CH, Wilkinson RD, Oakley JE, Lindgren F, Williams SE, O’Neill MD and Niederer SA
Ieee Transactions On Biomedical Engineering vol. 67 
01-01-2020
Quantifying atrial anatomy uncertainty from clinical data and its impact on electro-physiology simulation predictions
Corrado C, Razeghi O, Roney C, Coveney S, Williams S, Sim I, O’Neill M, Wilkinson R, Oakley J, Clayton RH and Niederer S
Medical Image Analysis vol. 61 
01-01-2020
Simulating ventricular systolic motion in a four-chamber heart model with spatially varying robin boundary conditions to model the effect of the pericardium
Strocchi M, Gsell MAF, Augustin CM, Razeghi O, Roney CH, Prassl AJ, Vigmond EJ, Behar JM, Gould JS, Rinaldi CA, Bishop MJ, Plank G and Niederer SA
Journal of Biomechanics vol. 101 
01-01-2020

2019

Standardised Framework for Quantitative Analysis of Fibrillation Dynamics
Li X, Roney CH, Handa BS, Chowdhury RA, Niederer SA, Peters NS and Ng FS
Scientific Reports, Springer Nature vol. 9 (1) 
13-11-2019
4969Enhanced gap junction coupling organised and terminated acute ventricular fibrillation in ex-vivo perfused hearts
Handa BS, Li X, Roney C, Pitcher D, Chowdhury RA, Peter NS and Ng FS
European Heart Journal, Oxford University Press (Oup) vol. 40 (Supplement_1) 
01-10-2019
Fundamentals of cardiac mapping
Ng FS, Roney C, Cantwell CD and Peters NS
In Cardiac Mapping 70-83.  
05-04-2019
A technique for measuring anisotropy in atrial conduction to estimate conduction velocity and atrial fibre direction
Roney CH, Whitaker J, Sim I, O’Neill L, Mukherjee RK, Razeghi O, Vigmond EJ, Wright M, O’Neill MD, Williams SE and Niederer SA
Computers in Biology and Medicine vol. 104 
01-01-2019
Preventing recurrence through analysing recurrence
Roney CH and Bishop MJ
Journal of Cardiovascular Electrophysiology vol. 30 
01-01-2019
Acetylcholine Delays Atrial Activation to Facilitate Atrial Fibrillation
Bayer JD, Boukens BJ, Krul SPJ, Roney CH, Driessen AHG, Berger WR, van den Berg NWE, Verkerk AO, Vigmond EJ, Coronel R and de Groot JR
Frontiers in Physiology vol. 10 
01-01-2019
Cardiac propagation pattern mapping with vector field for helping tachyarrhythmias diagnosis with clinical tridimensional electro-anatomical mapping tools
Dallet C, Roney C, Martin R, Kitamura T, Puyo S, Duchateau J, Dumas-Pomier C, Ravon G, Bear L, Derval N, Sacher F, Vigmond E, Haissaguerre M, Hocini M and Dubois R
Ieee Transactions On Biomedical Engineering vol. 66 
01-01-2019
Left atrial effective conducting size predicts atrial fibrillation vulnerability in persistent but not paroxysmal atrial fibrillation
Williams SE, O’Neill L, Roney CH, Julia J, Metzner A, Reißmann B, Mukherjee RK, Sim I, Whitaker J, Wright M, Niederer S, Sohns C and O’Neill M
Journal of Cardiovascular Electrophysiology 
01-01-2019
Reproducibility of Atrial Fibrosis Assessment Using CMR Imaging and an Open Source Platform
Sim I, Razeghi O, Karim R, Chubb H, Whitaker J, O’Neill L, Mukherjee RK, Roney CH, Razavi R, Wright M, O’Neill M, Niederer S and Williams SE
Jacc: Cardiovascular Imaging vol. 12 
01-01-2019
Universal atrial coordinates applied to visualisation, registration and construction of patient specific meshes
Roney CH, Pashaei A, Meo M, Dubois R, Boyle PM, Trayanova NA, Cochet H, Niederer SA and Vigmond EJ
Medical Image Analysis vol. 55 
01-01-2019

2018

116Inter and intra-observer reproducibility of atrial fibrosis assessment using late gadolinium enhanced cardiac magnetic resonance imaging
Sim I, Razeghi O, O'Neill L, Whitaker J, Mukherjee R, Roney C, Razavi R, O'Neill M, Niederer S and Williams S
Ep Europace vol. 20 (suppl_4), iv50-iv51.  
01-10-2018
Analytical approaches for myocardial fibrillation signals
Handa BS, Roney CH, Houston C, Qureshi NA, Li X, Pitcher DS, Chowdhury RA, Lim PB, Dupont E, Niederer SA, Cantwell CD, Peters NS and Ng FS
Computers in Biology and Medicine vol. 102 
01-01-2018
Characterisation of re-entrant circuit (or rotational activity) in vitro using the HL1-6 myocyte cell line
Houston C, Tzortzis KN, Roney C, Saglietto A, Pitcher DS, Cantwell CD, Chowdhury RA, Ng FS, Peters NS and Dupont E
Journal of Molecular and Cellular Cardiology vol. 119 
01-01-2018
Determinants of new wavefront locations in cholinergic atrial fibrillation
Roney CH, Ng FS, Debney MT, Eichhorn C, Nachiappan A, Chowdhury RA, Qureshi NA, Cantwell CD, Tweedy JH, Niederer SA, Peters NS and Vigmond EJ
Europace vol. 20 
01-01-2018
Variability in pulmonary vein electrophysiology and fibrosis determines arrhythmia susceptibility and dynamics
Roney CH, Bayer JD, Cochet H, Meo M, Dubois R, Jaïs P and Vigmond EJ
Plos Computational Biology vol. 14 
01-01-2018
Patient-specific simulations predict efficacy of ablation of interatrial connections for treatment of persistent atrial fibrillation
Roney CH, Williams SE, Cochet H, Mukherjee RK, O’Neill L, Sim I, Whitaker J, Razeghi O, Klein GJ, Vigmond EJ, O’Neill M and Niederer SA
Europace vol. 20 
01-01-2018
Repolarization abnormalities unmasked with exercise in sudden cardiac death survivors with structurally normal hearts
Leong KMW, Ng FS, Roney C, Cantwell C, Shun-Shin MJ, Linton NWF, Whinnett ZI, Lefroy DC, Davies DW, Harding SE, Lim PB, Francis D, Peters NS, Varnava AM and Kanagaratnam P
Journal of Cardiovascular Electrophysiology vol. 29 
01-01-2018
Unraveling the Underlying Arrhythmia Mechanism in Persistent Atrial Fibrillation: Results from the STARLIGHT Study
Child N, Clayton RH, Roney CH, Laughner JI, Shuros A, Neuzil P, Petru J, Jackson T, Porter B, Bostock J, Niederer SA, Razavi RS, Rinaldi CA, Taggart P, Wright MJ and Gill J
Circulation: Arrhythmia and Electrophysiology vol. 11 
01-01-2018
Wavelength and fibrosis affect phase singularity locations during atrial fibrillation
Saha M, Roney CH, Bayer JD, Meo M, Cochet H, Dubois R and Vigmond EJ
Frontiers in Physiology vol. 9 
01-01-2018

2017

P4350Slowing of conduction by acetylcholine shortens the wavelength for reentrant atrial arrhythmias
Bayer JD, Boukens BJ, Roney CH, Vigmond EJ, Krul SPJ, Driessen AHG, Berger WR, Van Den Berg NWE, De Groot JR and Coronel R
European Heart Journal, Oxford University Press (Oup) vol. 38 (suppl_1) 
01-08-2017
Rotor Tracking Using Phase of Electrograms Recorded During Atrial Fibrillation
Roney CH, Cantwell CD, Qureshi NA, Chowdhury RA, Dupont E, Lim PB, Vigmond EJ, Tweedy JH, Ng FS and Peters NS
Annals of Biomedical Engineering vol. 45 
01-01-2017
Spatial Resolution Requirements for Accurate Identification of Drivers of Atrial Fibrillation
Roney CH, Cantwell CD, Bayer JD, Qureshi NA, Lim PB, Tweedy JH, Kanagaratnam P, Peters NS, Vigmond EJ and Ng FS
Circulation: Arrhythmia and Electrophysiology vol. 10 
01-01-2017
ST-elevation magnitude correlates with right ventricular outflow tract conduction delay in Type I Brugada ECG
Leong KMW, Ng FS, Yao C, Roney C, Taraborrelli P, Linton NWF, Whinnett ZI, Lefroy DC, Davies DW, Boon Lim P, Harding SE, Peters NS, Kanagaratnam P and Varnava AM
Circulation: Arrhythmia and Electrophysiology vol. 10 
01-01-2017

2016

Modelling methodology of atrial fibrosis affects rotor dynamics and electrograms
Roney CH, Bayer JD, Zahid S, Meo M, Boyle PM, Trayanova NA, Haïssaguerre M, Dubois R, Cochet H and Vigmond EJ
Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of The Working Groups On Cardiac Pacing, Arrhyt vol. 18 
01-01-2016
Novel radiofrequency ablation strategies for terminating atrial fibrillation in the left atrium: A simulation study
Bayer JD, Roney CH, Pashaei A, Jaïs P and Vigmond EJ
Frontiers in Physiology vol. 7 
01-01-2016

2015

67 Dynamic Characterisation of the Electrophysiological Substrate in Brugada Syndrome During Physiological Autonomic Stimulation
Leong KMW, Ng FS, Roney C, Lim PB, Peters NS, Varnava A and Kanagaratnam P
Heart, Bmj vol. 101 (Suppl 4) 
01-06-2015
Techniques for automated local activation time annotation and conduction velocity estimation in cardiac mapping
Cantwell CD, Roney CH, Ng FS, Siggers JH, Sherwin SJ and Peters NS
Computers in Biology and Medicine vol. 65 
01-01-2015

2013

The contact electrogram and its architectural determinants in atrial fibrillation
Zaman JA, Al-Aidarous S, Patel PM, Debney MT, Roney C, Chang ET, Chowdhury RA and Peters N
The Lancet, Elsevier vol. 381 
01-02-2013

2012

117 Conduction block induced by acidosis in HL-1 mouse atrial myocytes can be reversed by administering the gap junctional coupler rotigaptide
Al-Aidarous SI, Roney CH, Peters FMD, Ng FS, Chowdhury RA and Peters NS
Heart, Bmj vol. 98 (Suppl 1) 
01-05-2012

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconDevelopment and Validation of Smartphone-Based Tools for Characterisation of Gait - QMUL-HUMA KTP
Caroline Roney, Zion Tse, Dylan Morrissey, Stuart Miller, Trevor Prior and Greg Slabaugh
£227,485 Innovate UK
01-08-2024 - 31-07-2026
solid heart iconEPSRC Centre for Doctoral Training in Next Generation Organ-on-a-Chip Technology (COaCT)
Hazel Screen, Martin Knight, Thomas Iskratsch, Caroline Roney, Yi Sui, David Lee, Julia Shelton, Zion Tse, John Connelly, Adrian Biddle and Lucy Norling
£7,066,811 EPSRC Engineering and Physical Sciences Research Council 
Grant Summary

01-07-2024 - 30-09-2032
bullet iconMapping populations to patients: designing optimal ablation therapy for atrial fibrillation through simulation and deep learning of digital twins (UKRI Future Leaders Fellowship)
Caroline Roney
£1,224,259 MRC Medical Research Council
01-11-2022 - 31-10-2026
bullet iconVirtual Atria with Personalised Electrophysiology for Atrial Fibrillation Therapy Planning
Caroline Roney and Thomas Iskratsch
£25,000 Acutus Medical UK Ltd
01-10-2022 - 30-09-2025


bullet iconSimplifying range of movement measurement in humans at home
Dylan Morrissey, Stuart Miller and Caroline Roney
£158,222 Huma Therapeutics Limited
01-03-2023 - 30-11-2023
bullet iconFellowship: Predicting atrial fibrillation mechanisms through deep learning
Caroline Roney
£95,574 MRC Medical Research Council
18-10-2021 - 31-10-2022