Dr Duco Koenis

Duco Koenis

Post-doctoral Researcher

Biochemical Pharmacology
William Harvey Research Institute

Research

Bone marrow, Hematopoiesis, Resolution of inflammation

Interests

I have previously worked with the Emulate organ-on-chip system

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2024

Koenis DS, Gogh IJAE, van Loenen PB, Zwart W, Kalkhoven E and de Vries CJM (2024). Nuclear receptor Nur77 and Yin‐Yang 1 synergistically increase mitochondrial abundance and activity in macrophages. Wiley  FEBS Letters  vol. 598, (14) 1715-1729.  

2023

Koenis DS, de Matteis R, Rajeeve V, Cutillas P and Dalli J (2023). Efferocyte‐Derived MCTRs Metabolically Prime Macrophages for Continual Efferocytosis via Rac1‐Mediated Activation of Glycolysis. Wiley  Advanced Science  vol. 11, (7)  
Ervik K, Reinertsen AF, Koenis DS, Dalli J and Hansen TV (2023). Stereoselective Synthesis, Pro-resolution, and Anti-inflammatory Actions of RvD5n‑3 DPA. American Chemical Society (ACS)  Journal of Natural Products  vol. 86, (11) 2546-2553.  

2022

Flak MB, Koenis DS, Gonzalez-Nunez M, Chopo-Pizarro A and Dalli J (2022). Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation. Elsevier  Biochemical Pharmacology  vol. 207,  
Nelson JK, Thin MZ, Evan T, Howell S, Wu M, Almeida B, Legrave N, Koenis DS, Koifman G, Sugimoto Y, Llorian Sopena M, MacRae J, Nye E, Howell M, Snijders AP, Prachalias A, Zen Y, Sarker D and Behrens A (2022). USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer. Springer Nature  Nature Communications  vol. 13, (1)  
Pistorius K, Ly L, Souza PR, Gomez EA, Koenis DS, Rodriguez AR, Foster J, Sosabowski J, Hopkinson M, Rajeeve V, Spur BW, Pitsillides A, Pitzalis C and Dalli J (2022). MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis. Elsevier  EBioMedicine  vol. 79,  

2021

Beegun I, Koenis DS, Alusi G and Dalli J (2021). Dysregulated Maresin Concentrations in Plasma and Nasal Secretions From Patients With Chronic Rhinosinusitis. Frontiers  Frontiers in Immunology  vol. 12,  
Koenis DS, Beegun I, Jouvene CC, Aguirre GA, Souza PR, Gonzalez-Nunez M, Ly L, Pistorius K, Kocher HM, Ricketts W, Thomas G, Perretti M, Alusi G, Pfeffer P and Dalli J (2021). Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19. Circulation Research  E54-E71.  
Jagusch H, Werner M, Koenis D, Dalli J, Werz O and Pohnert G (2021). 14,17,18-Trihydroxy-Eicosatetraenoic Acid: A Novel Pro-Resolving Lipid Mediator from Marine Microalgae. American Chemical Society (ACS)  ACS Pharmacology & Translational Science  vol. 4, (3) 1188-1194.  

2020

Marinković G, Koenis DS, de Camp L, Jablonowski R, Graber N, de Waard V, de Vries CJ, Goncalves I, Nilsson J, Jovinge S and Schiopu A (2020). S100A9 Links Inflammation and Repair in Myocardial Infarction. Wolters Kluwer  Circulation Research  vol. 127, (5) 664-676.  
van der Stoel M, Schimmel L, Nawaz K, van Stalborch A-M, de Haan A, Klaus-Bergmann A, Valent ET, Koenis DS, van Nieuw Amerongen GP, de Vries CJ, de Waard V, Gloerich M, van Buul JD and Huveneers S (2020). DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis. J Cell Sci   

2019

Flak MB, Koenis DS, Sobrino A, Smith J, Pistorius K, Palmas F and Dalli J (2019). GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in arthritis and infections. American Society for Clinical Investigation  Journal of Clinical Investigation  vol. 130, (1) 359-373.  

2018

Koenis DS, Medzikovic L, Vos M, Beldman TJ, van Loenen PB, van Tiel CM, Hamers AAJ, Otermin Rubio I, de Waard V and de Vries CJM (2018). Nur77 variants solely comprising the amino-terminal domain activate hypoxia-inducible factor-1α and affect bone marrow homeostasis in mice and humans. Elsevier  Journal of Biological Chemistry  vol. 293, (39) 15070-15083.  
Koenis DS, Medzikovic L, van Loenen PB, van Weeghel M, Huveneers S, Vos M, Gogh IJE-V, Van den Bossche J, Speijer D, Kim Y, Wessels L, Zelcer N, Zwart W, Kalkhoven E and de Vries CJ (2018). Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism. Elsevier  Cell Reports  vol. 24, (8) 2127-2140.e7.  
Medzikovic L, van Roomen C, Baartscheer A, van Loenen PB, de Vos J, Bakker ENTP, Koenis DS, Damanafshan A, Creemers EE, Arkenbout EK, de Vries CJM and de Waard V (2018). Nur77 protects against adverse cardiac remodelling by limiting Neuropeptide Y signalling in the sympathoadrenal-cardiac axis. Cardiovasc Res   
Kurakula K, Koenis DS, Herzik MA, Liu Y, Craft JW, van Loenen PB, Vos M, Tran MK, Versteeg HH, Goumans M-JTH, Ruf W, de Vries CJM and Şen M (2018). Structural and cellular mechanisms of peptidyl-prolyl isomerase Pin1-mediated enhancement of Tissue Factor gene expression, protein half-life, and pro-coagulant activity. Ferrata Storti Foundation (Haematologica)  Haematologica  vol. 103, (6) 1073-1082.  

2017

Cook ECL, Nelson JK, Sorrentino V, Koenis D, Moeton M, Scheij S, Ottenhoff R, Bleijlevens B, Loregger A and Zelcer N (2017). Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene. Public Library of Science (PLoS)  PLOS ONE  vol. 12, (2)  
Nelson JK, Koenis DS, Scheij S, Cook ECL, Moeton M, Santos A, Lobaccaro J-MA, Baron S and Zelcer N (2017). EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux. Wolters Kluwer  Arteriosclerosis Thrombosis and Vascular Biology  vol. 37, (3) 423-432.  

2016

Hamers AAJ, Argmann C, Moerland PD, Koenis DS, Marinković G, Sokolović M, de Vos AF, de Vries CJM and van Tiel CM (2016). Nur77-deficiency in bone marrow-derived macrophages modulates inflammatory responses, extracellular matrix homeostasis, phagocytosis and tolerance. Springer Nature  BMC Genomics  vol. 17, (1)  

2015

Tran MK, Kurakula K, Koenis DS and de Vries CJM (2015). Protein–protein interactions of the LIM-only protein FHL2 and functional implication of the interactions relevant in cardiovascular disease. Elsevier  Biochimica et Biophysica Acta  vol. 1863, (2) 219-228.  
Kurakula K, Sommer D, Sokolovic M, Moerland PD, Scheij S, van Loenen PB, Koenis DS, Zelcer N, van Tiel CM and de Vries CJM (2015). LIM-Only Protein FHL2 Is a Positive Regulator of Liver X Receptors in Smooth Muscle Cells Involved in Lipid Homeostasis. Taylor & Francis  Molecular and Cellular Biology  vol. 35, (1) 52-62.  

2014

Kurakula K, Koenis DS, van Tiel CM and de Vries CJM (2014). NR4A nuclear receptors are orphans but not lonesome. Elsevier  Biochimica et Biophysica Acta  vol. 1843, (11) 2543-2555.  

2012

van Tiel CM, Kurakula K, Koenis DS, van der Wal E and de Vries CJM (2012). Dual function of Pin1 in NR4A nuclear receptor activation: Enhanced activity of NR4As and increased Nur77 protein stability. Elsevier  Biochimica et Biophysica Acta  vol. 1823, (10) 1894-1904.