Prof David Lee

David Lee

Professor of Cell & Tissue Engineering

School of Engineering and Materials Science
Queen Mary University of London
www.sems.qmul.ac.uk/staff/d.a.lee

Research

Mechanobiology, Stem cell biology, Circadian biology, Musculoskeletal, Energy metabolism, Cartilage

Underpinning Bioengineering, Cancer Models, Cardiovascular Models, Musculoskeletal Models

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2022

Modulation of sirtuins during monolayer chondrocyte culture influences cartilage regeneration upon transfer to a 3D culture environment
Heywood HK, Thorpe SD, Jeropoulos RM, Caton PW and Lee DA
Frontiers in Bioengineering and Biotechnology, Frontiers Media vol. 10 
06-12-2022
Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems
Heywood HK, Gardner L, Knight MM and Lee DA
In Vitro Models, Springer Nature, 1-8.  
31-08-2022
Covariation of Pluripotency Markers and Biomechanical Properties in Mouse Embryonic Stem Cells
Brookes O, Thorpe SD, Evans OR, Keeling MC and Lee DA
Frontiers in Cell and Developmental Biology, Frontiers vol. 10 
16-05-2022

2021

G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization
Lachowski D, Cortes E, Matellan C, Rice A, Lee DA, Thorpe SD and del Río Hernández AE
Frontiers in Cell and Developmental Biology, Frontiers Media vol. 8, 592628-592628.  
22-01-2021

2020

GPER activation inhibits cancer cell mechanotransduction and basement membrane invasion via RhoA
Rice A, Cortes E, Lachowski D, Oertle P, Matellan C, Thorpe SD, Ghose R, Wang H, Lee DA, Plodinec M and Del Río Hernández AE
Cancers, Mdpi Ag vol. 12 (2) 
25-01-2020
Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway
Thorpe S, Chronopoulos A, Cortes E, Lachowski D, Rice A, Mykuliak V, Róg T, Lee D, Hytonen V and del Río Hernández A
Nature Materials, Nature Research 
06-01-2020

2018

Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor
Cortes E, Lachowski D, Rice A, THORPE SD, Robinson B, Yeldag G, LEE DA, Ghemtio L, Rombouts K and del Río Hernández AE
Oncogene, Springer Nature [Academic Journals On Nature.Com] 
21-12-2018
Tamoxifen mechanically reprograms the tumor microenvironment via HIF‐1A and reduces cancer cell survival
Cortes E, Lachowski D, Robinson B, Sarper M, Teppo JS, Thorpe SD, Lieberthal TJ, Iwamoto K, Lee DA, Okada‐Hatakeyama M, Varjosalo MT and del Río Hernández AE
Embo Reports, Springer Nature vol. 20 (1) 
12-12-2018
GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment
Cortes E, Sarper M, Robinson B, Lachowski D, Chronopoulos A, Thorpe SD, Lee DA and del Río Hernández AE
Embo Reports, Springer Nature vol. 20 (1) 
11-12-2018
RAR‐β is downregulated in HCC & cirrhosis and its expression inhibits myosin‐driven activation and durotaxis in hepatic stellate cells
Cortes E, Lachowski D, Rice A, Chronopoulos A, Robinson B, THORPE SD, LEE DA, Possamai LA, Wang H, Pinato DJ and del Rio Hernández AE
Hepatology, Wiley 
28-07-2018

2017

Development of a two-stage gene selection method that incorporates a novel hybrid approach using the cuckoo optimization algorithm and harmony search for cancer classification
Elyasigomari V, Lee DA, Screen HRC and SHAHEED MH
Journal of Biomedical Informatics vol. 67 (2017), 11-20.  
03-02-2017
Dynamic regulation of nuclear architecture and mechanics—a rheostatic role for the nucleus in tailoring cellular mechanosensitivity
THORPE SD and Lee DA
Nucleus, Taylor & Francis vol. 8 (3), 287-300.  
02-02-2017

2016

Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity.
Heo S-J, Driscoll TP, Thorpe SD, Nerurkar NL, Baker BM, Yang MT, Chen CS, Lee DA and Mauck RL
Elife, Elife Sciences Publications Ltd vol. 5 
30-11-2016
Oxygen tension modulates the effects of TNFα in compressed chondrocytes.
Tilwani RK, Vessillier S, Pingguan-Murphy B, Lee DA, Bader DL and Chowdhury TT
Inflamm Res 
22-09-2016
Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells
Heo SJ, Han WM, Szczesny SE, Cosgrove BD, Elliott DM, Lee DA, Duncan RL and Mauck RL
Biophysical Journal vol. 111 (4), 864-874.  
23-08-2016
Bioenergetic reprogramming of articular chondrocytes by exposure to exogenous and endogenous reactive oxygen species and its role in the anabolic response to low oxygen
Heywood HK and Lee DA
Journal of Tissue Engineering and Regenerative Medicine vol. 11 (8), 2286-2294.  
22-06-2016
Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion
Sliogeryte K, Botto L, Lee DA and Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 24 (5), 912-920.  
01-05-2016
States rights and Australia’s adoption of the statute of Westminster, 1931–1942
Lee D
History Australia, Taylor & Francis vol. 13 (2), 258-274.  
02-04-2016
Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility
Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM and Connelly JT
Journal of Investigative Dermatology, Elsevier vol. 136 (1), 74-83.  
01-01-2016
Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility.
Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM and Connelly JT
J Invest Dermatol vol. 136 (1), 74-83.  
01-01-2016

2015

Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells
Heo S-J, Thorpe SD, Driscoll TP, Duncan RL, Lee DA and Mauck RL
Scientific Reports, Springer Nature vol. 5 (1) 
23-11-2015
FINITE ELEMENT ANALYSIS OF MECHANICAL DEFORMATION OF CHONDROCYTE TO 2D SUBSTRATE AND 3D SCAFFOLD
CHEN J, BADER DL, LEE DA and KNIGHT MM
Journal of Mechanics in Medicine and Biology, World Scientific Publishing vol. 15 (05) 
01-10-2015

2014

Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics
Sliogeryte K, Thorpe SD, Lee DA, Botto L and Knight MM
Scientific Reports, Springer Nature vol. 4 (1) 
04-12-2014
Quantification of chromatin condensation level by image processing.
Irianto J, Lee DA and Knight MM
Med Eng Phys vol. 36 (3), 412-417.  
01-03-2014
Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture.
Heywood HK, Nalesso G, Lee DA and Dell'accio F
Biores Open Access vol. 3 (1), 9-18.  
01-02-2014

2013

Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes.
Irianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE and Lee DA
Biophys J vol. 104 (4), 759-769.  
19-02-2013
Continuous and Uninterrupted Oxygen Tension Influences the Colony Formation and Oxidative Metabolism of Human Mesenchymal Stem Cells
Pattappa G, Thorpe SD, Jegard NC, Heywood HK, de Bruijn JD and Lee DA
Tissue Engineering Part C-Methods vol. 19 (1) 
01-01-2013
Reluctant relaxation
Lee D
History Australia, Taylor & Francis vol. 10 (3), 149-170.  
01-01-2013

2012

New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures
Sillitoe I, Cuff AL, Dessailly BH, Dawson NL, Furnham N, Lee D, Lees JG, Lewis TE, Studer RA, Rentzsch R, Yeats C, Thornton JM and Orengo CA
Nucleic Acids Research, Oxford University Press (Oup) vol. 41 (D1), d490-d498.  
29-11-2012
Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment.
Chen J, Irianto J, Inamdar S, Pravincumar P, Lee DA, Bader DL and Knight MM
Biophys J vol. 103 (6), 1188-1197.  
19-09-2012
Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: a case study.
Bonzani IC, Campbell JJ, Knight MM, Williams A, Lee DA, Bader DL and Stevens MM
J Mech Behav Biomed Mater vol. 11, 72-81.  
01-07-2012
The mechanics of flexor tendon adhesions
Branford OA, Lee DA, Bader DL and Grobbelaar AO
Journal of Hand Surgery: European Volume vol. 37 (6), 555-563.  
01-07-2012
The attachment of intrinsic and extrinsic, mobilized and immobilized adhesion cells to collagen and fibronectin
Branford OA, Lee DA, Rolfe KJ and Grobbelaar AO
Journal of Hand Surgery: European Volume vol. 37 (6), 564-572.  
01-07-2012
Improving metabolic flux predictions using absolute gene expression data
Lee D, Smallbone K, Dunn WB, Murabito E, Winder CL, Kell DB, Mendes P and Swainston N
Bmc Systems Biology, Springer Nature vol. 6 (1) 
19-06-2012
Stanley Melbourne Bruce in London, 1938–41
Lee D
The Journal of Imperial & Commonwealth History, Taylor & Francis vol. 40 (1), 45-65.  
01-03-2012
Scaling and mesostructure of Carbopol dispersions
Gutowski IA, Lee D, de Bruyn JR and Frisken BJ
Rheologica Acta, Springer Nature vol. 51 (5), 441-450.  
18-01-2012
Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations.
Hosny NA, Lee DA and Knight MM
J Biomed Opt vol. 17 (1) 
01-01-2012
Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading
Maeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA
Biomechanics and Modeling in Mechanobiology vol. 11 (3-4), 439-447.  
01-01-2012
Mechanical regulation of nuclear structure and function.
Martins RP, Finan JD, Guilak F and Lee DA
Annu Rev Biomed Eng vol. 14, 431-455.  
01-01-2012

2011

White Globules in Melanocytic Neoplasms: In Vivo and Ex Vivo Characteristics
Jaimes N, Scope A, Welzel J, Wang KX, Lee DA, Siegel DM and Marghoob AA
Dermatologic Surgery, Wolters Kluwer vol. 38 (1), 128-132.  
31-10-2011
The metabolism of human mesenchymal stem cells during proliferation and differentiation.
Pattappa G, Heywood HK, de Bruijn JD and Lee DA
J Cell Physiol vol. 226 (10), 2562-2570.  
01-10-2011
Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment.
Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC
Proc Inst Mech Eng H vol. 225 (8), 821-830.  
01-08-2011
Extensive oral herpes simplex virus type 1 infection in a haematopoietic stem cell transplant recipient not responding to aciclovir
Moses SE, Osborne W, Valappil M, Collin M, Lee D, Waugh S, Jackson G, Parry CM and Crowley B
Journal of Clinical Virology, Elsevier vol. 52 (2), 67-69.  
14-06-2011
Investigating the microstructure of a yield-stress fluid by light scattering
Lee D, Gutowski IA, Bailey AE, Rubatat L, de Bruyn JR and Frisken BJ
Physical Review E, American Physical Society (Aps) vol. 83 (3) 
01-03-2011
Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading
Maeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA
Biomechanics and Modeling in Mechanobiology, 1-9.  
01-01-2011
Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment
Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC
P I Mech Eng H vol. 225 (H8), 821-830.  
01-01-2011
Electrospray deposited fibronectin retains the ability to promote cell adhesion
Martyn SV, Heywood HK, Rockett P, Paine MD, Wang MJ, Dobson PJ, Sheard SJ, Lee DA and Stark JPW
Journal of Biomedical Materials Research - Part B Applied Biomaterials vol. 96 B (1), 110-118.  
01-01-2011
Stem cell mechanobiology.
Lee DA, Knight MM, Campbell JJ and Bader DL
J Cell Biochem vol. 112 (1), 1-9.  
01-01-2011
1,000 structures and more from the MCSG
Lee D, de Beer TA, Laskowski RA, Thornton JM and Orengo CA
Bmc Molecular and Cell Biology, Springer Nature vol. 11 (1) 
01-01-2011
Novel devices for diagnosis and treatment.
Lee DA and Siegel DM
Journal of Drugs in Dermatology vol. 10 (1), 21-22.  
01-01-2011
Quantification of mRNA using real-time PCR and Western blot analysis of MAPK events in chondrocyte/agarose constructs.
Lee DA, Brand J, Salter D, Akanji O-O and Chowdhury TT
Methods Mol Biol vol. 695, 77-97.  
01-01-2011

2010

The metabolism of human mesenchymal stem cells during proliferation and differentiation.
Pattappa G, Heywood HK, de Bruijn JD and Lee DA
J Cell Physiol 
28-12-2010
Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strain
Maeda E, Fleischmann C, Mein CA, Shelton JC, Bader DL and Lee DA
Connective Tissue Research vol. 51 (6), 434-444.  
01-12-2010
Both superficial and deep zone articular chondrocyte subpopulations exhibit the crabtree effect but have different basal oxygen consumption rates
Heywood HK, Knight MM and Lee DA
Journal of Cellular Physiology vol. 223 (3), 630-639.  
01-06-2010
Giving something back
Lee D
Twist (22), 28-30.  
01-06-2010
A compartment model to evaluate the permeability of gap junctions between tenocytes in tendon fascicles
Ye S, Maeda E, Knight M, Lee D, Bader D and Wang W
Faseb Journal vol. 24 
01-01-2010
Low oxygen reduces the modulation to an oxidative phenotype in monolayer-expanded chondrocytes.
Heywood HK and Lee DA
J Cell Physiol vol. 222 (1), 248-253.  
01-01-2010

2009

Effect of intermittent cyclic tensile strain on collagen synthesis by tenocytes in isolated fascicles
Maeda E, Shelton JC, Bader DL and Lee DA
Journal of Biomechanical Science and Engineering vol. 4 (4), 510-517.  
01-12-2009
GeMMA: functional subfamily classification within superfamilies of predicted protein structural domains
Lee DA, Rentzsch R and Orengo C
Nucleic Acids Research, Oxford University Press (Oup) vol. 38 (3), 720-737.  
18-11-2009
The effect of oxygen tension on the proliferation and differentiation of human mesenchymal stem cells
Pattappa G, Jegard NC, Lee DA and de Bruijn JD
European Cells and Materials vol. 18 (SUPPL. 1) 
01-08-2009
Osteogenic differentiation of human mesenchymal stem cells within a perfused bioreactor system
Campbell JJ, Maeda E, Ye SJ, Wang W and Lee DA
European Cells and Materials vol. 18 (SUPPL. 2) 
01-07-2009
The influence of oxygen tension on the colony formation and proliferation of human mesenchymal stem cells
Pattappa G, Jegard NC, de Bruijn JD and Lee DA
European Cells and Materials vol. 18 (SUPPL. 2) 
01-07-2009
Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitro
Maeda E, Shelton JC, Bader DL and Lee DA
Journal of Applied Physiology vol. 106 (2), 506-512.  
01-02-2009
The development of a bioreactor to perfuse radially-confined hydrogel constructs: design and characterization of mass transport properties.
Eniwumide JO, Lee DA and Bader DL
Biorheology vol. 46 (5), 417-437.  
01-01-2009
Cell-generated forces influence the viability, metabolism and mechanical properties of fibroblast-seeded collagen gel constructs.
Berry CC, Shelton JC and Lee DA
J Tissue Eng Regen Med vol. 3 (1), 43-53.  
01-01-2009

2008

Metabolic characteristics of human mesenchymal stem cells expanded under normoxic conditions
Pattappa G, A. Lee D and De Bruijn JD
8th World Biomaterials Congress 2008 vol. 1 
01-12-2008
Phenotypic analysis of Arabidopsis mutants: heavy metal stress.
Lee D and Schroeder J
Cold Spring Harbor Protocols, Cold Spring Harbor Laboratory vol. 2008 (9) 
01-09-2008
Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes.
Heywood HK and Lee DA
Biochem Biophys Res Commun vol. 373 (2), 224-229.  
22-08-2008
Collagen synthesis by tenocytes in fascicles subjected to intermittent cyclic strain
Maeda E, Shelton JC, Bader DL and Lee DA
European Cells and Materials vol. 16 (SUPPL. 3) 
01-07-2008
The effect of oxygen supply on chondrocyte metabolic phenotype during monolayer culture
Heywood HK and Lee DA
European Cells and Materials vol. 16 (SUPPL. 3) 
01-07-2008
Signal transduction pathways involving p38 MAPK, JNK, NF kappa B and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1 beta and dynamic compression
Chowdhury TT, Salter DM, Bader DL and Lee DA
Inflamm Res vol. 57 (7), 306-313.  
01-07-2008
Advantages, Disadvantages, and Uses of Generalized Activity Networks for Schedule Estimation
Hughes D, Whitaker Y, Lee D and Eckhause J
Military Operations Research, Military Operations Research Society vol. 13 (3), 27-40.  
01-06-2008
Mechanical loading modulates intracellular calcium signaling in human mesenchymal stem cells
Campbell JJ, Bader DL and Lee DA
J Appl Biomater Biom vol. 6 (1), 9-15.  
01-01-2008
Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs.
Chowdhury TT, Arghandawi S, Brand J, Akanji OO, Bader DL, Salter DM and Lee DA
Arthritis Res Ther vol. 10 (2) 
01-01-2008
Dynamic compression influences interleukin-1 beta-induced nitric oxide and prostaglandin E-2 release by articular chondrocytes via alterations in iNOS and COX-2 expression
Chowdhury TT, Akanji OO, Salter DM, Bader DL and Lee DA
Biorheology vol. 45 (3-4), 257-274.  
01-01-2008
Surgeons carry out first implant of pulmonary human heart valve
Lee DA
Biomedical Materials (MAY) 
01-01-2008

2007

52 REAL-TIME PCR USING MOLECULAR BEACONS TO DETECT INOS AND COX-2 EXPRESSION IN CHONDROCYTE/AGAROSE CONSTRUCTS SUBJECTED TO IL-1β AND DYNAMIC COMPRESSION
Chowdhury TT, Akanji OO, Arghandawi S, Salter DM, Bader DL and Lee DA
Osteoarthritis and Cartilage, Elsevier vol. 15, c42-c43.  
01-12-2007
Predicting protein function from sequence and structure
Lee D, Redfern O and Orengo C
Nature Reviews Molecular Cell Biology, Springer Nature vol. 8 (12), 995-1005.  
01-12-2007
Root contact during insertion of miniscrews for orthodontic anchorage increases the failure rate: an animal study
Chen Y-H, Chang H-H, Chen Y-J, Lee D, Chiang H-H and Jane Yao C-C
Clinical Oral Implants Research, Wiley, 07102500154-???.  
23-10-2007
Time dependence of cyclic tensile strain on collagen production in tendon fascicles.
Maeda E, Shelton JC, Bader DL and Lee DA
Biochem Biophys Res Commun vol. 362 (2), 399-404.  
19-10-2007
Products: CryoLife wins US patent for foam wound sealant
Lee DA
Biomedical Materials (JULY) 
01-01-2007
Products: CryoLife wins rights to distribute replacement pericardium
Lee DA and Hall J
Biomedical Materials (MAR.) 
01-01-2007
Industry news: CryoLife signs Irish distribution deal with Proxy Biomedical
Lee DA
Biomedical Materials (NOV.), 6-7.  
01-01-2007

2006

Glucose Concentration and Medium Volume Influences Cell Viability and Glycosaminoglycan Synthesis in Chondrocyte-Seeded Alginate Constructs
Heywood HK, Bader DL and Lee DA
Tissue Engineering, Mary Ann Liebert 
20-11-2006
Self-Assembly of Latex Particles into Proton-Conductive Membranes
Gao J, Yang Y, Lee D, Holdcroft S and Frisken BJ
Macromolecules, American Chemical Society (Acs) vol. 39 (23), 8060-8066.  
17-10-2006
The influence of swelling and matrix degradation on the microstructural integrity of tendon.
Screen HRC, Chhaya VH, Greenwald SE, Bader DL, Lee DA and Shelton JC
Acta Biomater vol. 2 (5), 505-513.  
01-09-2006
Direct current influences Ca 2+ signalling in chondrocytes
Akanji OO, Bader DL and Lee DA
European Cells and Materials vol. 11 (SUPPL.2) 
01-06-2006
Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields
Knight MM, Bomzon Z, Kimmel E, Sharma AM, Lee DA and Bader DL
Biomech Model Mechan vol. 5 (2-3), 180-191.  
01-06-2006
Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes.
Chowdhury TT, Appleby RN, Salter DM, Bader DA and Lee DA
Biomech Model Mechanobiol vol. 5 (2-3), 192-201.  
01-06-2006
1.3 The quantitative assessment of flexor tendon adhesion – a novel use of confocal microscopy to evaluate local strain, orientation and organisation
BRANFORD O, LEE D, BADER D and GROBBELAAR A
Journal of Hand Surgery (European Volume), Sage Publications vol. 31, 3-3.  
01-06-2006
Ground plans [13]
Lee D
Professional Engineering vol. 19 (6) 
22-03-2006
Comprehensive genome analysis of 203 genomes provides structural genomics with new insights into protein family space
Marsden RL, Lee D, Maibaum M, Yeats C and Orengo CA
Nucleic Acids Research, Oxford University Press (Oup) vol. 34 (3), 1066-1080.  
06-02-2006
Rate of oxygen consumption by isolated articular chondrocytes is sensitive to medium glucose concentration
Heywood HK, Bader DL and Lee DA
Journal of Cellular Physiology vol. 206 (2), 402-410.  
01-02-2006
Exploiting protein structure data to explore the evolution of protein function and biological complexity
Marsden RL, Ranea JAG, Sillero A, Redfern O, Yeats C, Maibaum M, Lee D, Addou S, Reeves GA, Dallman TJ and Orengo CA
Philosophical Transactions of The Royal Society B Biological Sciences, The Royal Society vol. 361 (1467), 425-440.  
01-02-2006
Anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated chondrocytes.
Chowdhury TT, Bader DL and Lee DA
Biochem Biophys Res Commun vol. 339 (1), 241-247.  
06-01-2006
Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose.
Knight MM, Toyoda T, Lee DA and Bader DL
J Biomech vol. 39 (8), 1547-1551.  
01-01-2006
Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs.
Chowdhury TT, Bader DL and Lee DA
Biorheology vol. 43 (3,4), 413-429.  
01-01-2006
Chondrocyte Deformation and Mechanotransduction in Cartilage Model Systems(International Workshop 2)
Bader DL, Lee DA and Knight MM
The Proceedings of The Bioengineering Conference Annual Meeting of Bed/Jsme, Japan Society of Mechanical Engineers vol. 2005.18, 2-3.  
01-01-2006
P140 DYNAMIC COMPRESSION COUNTERACTS FIBRONECTIN FRAGMENT INDUCED UPREGULATION OF NITRIC OXIDE
Chowdhury TT, Raveenthiran SP, Bader DL and Lee DA
Osteoarthritis and Cartilage, Elsevier vol. 14 
01-01-2006
Gene3D: modelling protein structure, function and evolution
Yeats C, Maibaum M, Marsden R, Dibley M, Lee D, Addou S and Orengo CA
Nucleic Acids Research, Oxford University Press (Oup) vol. 34 (suppl_1), d281-d284.  
01-01-2006
Industry news: CryoLife, BioForm sign glue deal
Lee DA and Gridley A
Biomedical Materials (DEC.), 7-8.  
01-01-2006
Products: Spinal implant looks good so far
Lee DA
Biomedical Materials (JUNE), 4-5.  
01-01-2006
Spinal implants: CryoLife's spinal disc repair study completes enrolment
Lee DA
Biomedical Materials (SEP.), 9-10.  
01-01-2006
Government: US law ensures funding for protein hydrogel development
Lee DA
Biomedical Materials (DEC.) 
01-01-2006
Concentration and M/G ratio influence the physiochemical and mechanical properties of alginate constructs for tissue engineering.
Enobakhare B, Bader DL and Lee DA
J Appl Biomater Biomech vol. 4 (2), 87-96.  
01-01-2006

2005

Cyclic mechanical conditioning of isolated tendon fascicles results in an upregulation of collagen production
Screen HRC, Bader DL, Shelton JC and Lee DA
Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 193-194.  
01-12-2005
Dynamic compression counteracts IL-1-induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs
Chowdhury TT, Bader DL and Lee DA
Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 251-252.  
01-12-2005
Integrin mediated mechanotransduction in IL-1 stimulated bovine chondrocytes cultured in agarose constructs
Chowdhury TT, Appleby RN, Salter DA, Bader DL and Lee DA
Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 545-546.  
01-12-2005
Identification and characterization of deposited fibronectin on biocompatible materials: Comparison of electrospray and wetting methods
Wang MJ, Heywood HK, Bader DL, Paine MD, Stark JPW and Lee DA
Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 439-440.  
01-12-2005
Mechanical conditioning of cell-seeded constructs for soft tissue repair - Are optimisation strategies possible?
Bader DL and Lee DA
, 165-192.  
01-12-2005
Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles.
Pingguan-Murphy B, Lee DA, Bader DL and Knight MM
Arch Biochem Biophys vol. 444 (1), 45-51.  
01-12-2005
Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles.
Screen HRC, Shelton JC, Bader DL and Lee DA
Biochem Biophys Res Commun vol. 336 (2), 424-429.  
21-10-2005
Nutrient utilization by bovine articular chondrocytes: a combined experimental and theoretical approach.
Sengers BG, Heywood HK, Lee DA, Oomens CWJ and Bader DL
J Biomech Eng vol. 127 (5), 758-766.  
01-10-2005
The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles.
Screen HRC, Shelton JC, Chhaya VH, Kayser MV, Bader DL and Lee DA
Ann Biomed Eng vol. 33 (8), 1090-1099.  
01-08-2005
Dynamic compression counteracts IL-1β induced INOS and COX-2 activity by human chondrocytes cultured in agarose constructs
Chowdhury TT, Bader DL and Lee DA
European Cells and Materials vol. 10 (SUPPL.2) 
01-07-2005
Dynamic compression influences the biochemical response of human mesenchymal stem cells cultured in agarose constructs
Catuogno C, Chowdhury TT, Bader DL and Lee DA
European Cells and Materials vol. 10 (SUPPL.2) 
01-07-2005
Perfusion-Enhancement of molecular transport within 3D scaffolds
Eniwumide JO, Lee DA and Bader DL
European Cells and Materials vol. 10 (SUPPL.2) 
01-07-2005
Superficial and deep chondrocyte subpopulations both express the crabtree effect but exhibit differences in oxygen consumption rate
Heywood HK, Bader DL and Lee DA
European Cells and Materials vol. 10 (SUPPL.2) 
01-07-2005
Mechanical conditioning Influences Mesenchymal stem cell chondrogenesis
Campbell JJ, Lee DA and Bader DL
European Cells and Materials vol. 10 (SUPPL.2) 
01-07-2005
Self-Assembly of Surface-Charged Latex Nanoparticles: A New Route to the Creation of Continuous Channels for Ion Conduction
Gao J, Lee D, Yang Y, Holdcroft S and Frisken BJ
Macromolecules, American Chemical Society (Acs) vol. 38 (14), 5854-5856.  
15-06-2005
British Society for Matrix Biology Autumn Meeting Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UK

International Journal of Experimental Pathology, Wiley vol. 86 (3), a1-a56.  
24-05-2005
Identification and distribution of protein families in 120 completed genomes using Gene3D
Lee D, Grant A, Marsden RL and Orengo C
Proteins Structure Function and Bioinformatics, Wiley vol. 59 (3), 603-615.  
14-03-2005
Compression-induced damage in a muscle cell model in vitro.
Wang Y-N, Bouten CVC, Lee DA and Bader DL
Proc Inst Mech Eng H vol. 219 (1), 1-12.  
01-01-2005
Autologous chondrocyte implantation. Culture in a TGF-beta-containing medium enhances the re-expression of a chondrocytic phenotype in passaged human chondrocytes in pellet culture.
Goldberg AJ, Lee DA, Bader DL and Bentley G
J Bone Joint Surg Br vol. 87 (1), 128-134.  
01-01-2005

2004

The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis
Pearl F, Todd A, Sillitoe I, Dibley M, Redfern O, Lewis T, Bennett C, Marsden R, Grant A, Lee D, Akpor A, Maibaum M, Harrison A, Dallman T, Reeves G, Diboun I, Addou S, Lise S, Johnston C, Sillero A, Thornton J and Orengo C
Nucleic Acids Research, Oxford University Press (Oup) vol. 33 (suppl_1), d247-d251.  
17-12-2004
Delusional discourse: An investigation comparing the spontaneous causal attributions of paranoid and non‐paranoid individuals
Lee DA, Randall F, Beattie G and Bentall RP
Psychology and Psychotherapy Theory Research and Practice, Wiley vol. 77 (4), 525-540.  
01-12-2004
Local Strain Measurement within Tendon
Bader DL, Shelton JC, Lee DA and SCREEN HRC
Strain vol. 40 (4), 157-163.  
01-11-2004
Crosslinking density influences the morphology of chondrocytes photoencapsulated in PEG hydrogels during the application of compressive strain.
Bryant SJ, Anseth KS, Lee DA and Bader DL
J Orthop Res vol. 22 (5), 1143-1149.  
01-09-2004
Integrin-mediated mechanotransduction processes in TGFbeta-stimulated monolayer-expanded chondrocytes.
Chowdhury TT, Salter DM, Bader DL and Lee DA
Biochem Biophys Res Commun vol. 318 (4), 873-881.  
11-06-2004
Debt crisis looms [10]
Lee D
Professional Engineering vol. 17 (8) 
28-04-2004
Activin Receptor-like Kinase-7 Induces Apoptosis through Activation of MAPKs in a Smad3-dependent Mechanism in Hepatoma Cells*
Kim B-C, van Gelder H, Kim TA, Lee H-J, Baik KG, Chun HH, Lee DA, Choi KS and Kim S-J
Journal of Biological Chemistry, Elsevier vol. 279 (27), 28458-28465.  
23-04-2004
Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels.
Bryant SJ, Chowdhury TT, Lee DA, Bader DL and Anseth KS
Ann Biomed Eng vol. 32 (3), 407-417.  
01-03-2004
Extracellular matrix influences the response of chondrocytes to dynamic compression
LEE DA, van Osch G, Verhaar JAN, Mandl EW, van der Linden JC, van der Breevaart Bravenboer J and Weinans H
Trans. Orthop.Rev. Soc vol. 29, 839-839.  
01-01-2004
Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain.
Lee DA and Knight MM
Methods Mol Med vol. 100, 307-324.  
01-01-2004
An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties.
Screen HRC, Lee DA, Bader DL and Shelton JC
Proc Inst Mech Eng H vol. 218 (2), 109-119.  
01-01-2004
Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage
Bader DL, KNIGHT MM, Bentley G, Kayser M and Holloway I
Osteoarthritis Cartilage vol. 12 (1), 17-24.  
01-01-2004
Bioreactor Culture Techniques for Cartilage-Tissue Engineering
Lee DA and Martin I
In Biopolymer Methods in Tissue Engineering, Springer Nature 159-170.  
01-01-2004
Passage in monolayer influences the response of chondrocytes to dynamic compression.
Wiseman M, Bader DL, Reisler T and Lee DA
Biorheology vol. 41 (3-4), 283-298.  
01-01-2004
Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage.
Holloway I, Kayser M, Lee DA, Bader DL, Bentley G and Knight MM
Osteoarthritis Cartilage vol. 12 (1), 17-24.  
01-01-2004
Mechanical Loading of Chondrocytes Embedded in 3D Constructs
Lee DA and Knight MM
In Cartilage and Osteoarthritis, Springer Nature 307-324.  
01-01-2004
Cellular utilization determines viability and matrix distribution profiles in chondrocyte-seeded alginate constructs.
Heywood HK, Sembi PK, Lee DA and Bader DL
Tissue Eng vol. 10 (9-10), 1467-1479.  
01-01-2004
Progress towards mapping the universe of protein folds
Grant A, Lee D and Orengo C
Genome Biology, Springer Nature vol. 5 (5) 
01-01-2004
EyeSite: a semi‐automated database of protein families in the eye
Lee DA, Fefeu S, Edo-Ukeh AA, Orengo CA and Slingsby C
Nucleic Acids Research, Oxford University Press (Oup) vol. 32 (suppl_1), d148-d152.  
01-01-2004

2003

Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression.
Chowdhury TT, Bader DL, Shelton JC and Lee DA
Arch Biochem Biophys vol. 417 (1), 105-111.  
01-09-2003
Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs.
Chowdhury TT, Bader DL and Lee DA
Osteoarthritis Cartilage vol. 11 (9), 688-696.  
01-09-2003
Influence of external uniaxial cyclic strain on oriented fibroblast-seeded collagen gels.
Berry CC, Shelton JC, Bader DL and Lee DA
Tissue Eng vol. 9 (4), 613-624.  
01-08-2003
Dynamic compressive strain inhibits nitric oxide synthesis by equine chondrocytes isolated from different areas of the cartilage surface.
Wiseman M, Henson F, Lee DA and Bader DL
Equine Vet J vol. 35 (5), 451-456.  
01-07-2003
A structural perspective on genome evolution
Lee D, Grant A, Buchan D and Orengo C
Current Opinion in Structural Biology, Elsevier vol. 13 (3), 359-369.  
01-06-2003
Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death.
Knight MM, Roberts SR, Lee DA and Bader DL
Am J Physiol Cell Physiol vol. 284 (4), C1083-C1089.  
01-04-2003
Expansion of chondrocytes for tissue engineering in alginate beads enhances chondrocytic phenotype compared to conventional monolayer techniques.
Lee DA, Reisler T and Bader DL
Acta Orthop Scand vol. 74 (1), 6-15.  
01-02-2003
Mechanical conditioning influences the metabolic response of cell-seeded constructs.
Shelton JC, Bader DL and Lee DA
Cells Tissues Organs vol. 175 (3), 140-150.  
01-01-2003
Trimethylaminuria and a human FMO3 mutation database
Hernandez D, Addou S, Lee D, Orengo C, Shephard EA and Phillips IR
Hum Mutat vol. 22 (3), 209-213.  
01-01-2003
Dermal fibroblasts respond to mechanical conditioning in a strain profile dependent manner.
Berry CC, Cacou C, Lee DA, Bader DL and Shelton JC
Biorheology vol. 40 (1-3), 337-345.  
01-01-2003
Development of a technique to determine strains in tendons using the cell nuclei.
Screen HRC, Lee DA, Bader DL and Shelton JC
Biorheology vol. 40 (1-3), 361-368.  
01-01-2003
alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta-stimulated human chondrocyte / agarose constructs and subjected to dynamic compression.
Chowdhury TT, LEE DA, Salter DM, Shelton JC and Bader DL
Osteoarthritis Cartilage vol. 11 (Suppl 1), S2-S3.  
01-01-2003
Control of mechanotrasduction processes in dynamically stimulated human and bovine chondrocytes cultured in agarose constructs.
Chowdhury TT, Shelton JC, Bader DL and LEE DA
Internat. J. Artificial Organs vol. 26 (9), 858-858.  
01-01-2003
Experimental and theoretical analysis of glucose dependent oxygen utilization by bovine articular chondrocytes
LEE DA, Heywood HK, Baaijens FPT, Oomens CWJ and Sengers BG
Internat. J. Artificial Organs vol. 26, 875-875.  
01-01-2003

2002

The influence of uniaxial cyclic strain on orientated fibroblast seeded collagen gels
Berry CC, Shelton JC, Bader DL and Lee DA
Third Smith and Nephew International Symposium - Translating Tissue Engineering Into Products 
01-12-2002
The design of bioreactor systems for cartilage tissue engineering
Lee DA
Third Smith and Nephew International Symposium - Translating Tissue Engineering Into Products 
01-12-2002
The origin of [Fe ii] emission in NGC 4151
Turner JEH, Allington-Smith J, Chapman S, Content R, Done C, Haynes R, Lee D and Morris S
Monthly Notices of The Royal Astronomical Society, Oxford University Press (Oup) vol. 331 (2), 284-292.  
01-03-2002
Cell and nucleus deformation in compressed chondrocyte-alginate constructs: temporal changes and calculation of cell modulus.
Knight MM, van de Breevaart Bravenboer J, Lee DA, van Osch GJVM, Weinans H and Bader DL
Biochim Biophys Acta vol. 1570 (1), 1-8.  
15-02-2002
The CATH extended protein‐family database: Providing structural annotations for genome sequences
Pearl FMG, Lee D, Bray JE, Buchan DWA, Shepherd AJ and Orengo CA
Protein Science, Wiley vol. 11 (2), 233-244.  
01-02-2002
Development of a technique to determine strains in tendons using the cell nuclei.
BADER DL, Shelton JC, Lee DA and Screen HRC
Biorheology vol. 40, 361-368.  
01-01-2002
Non-collagenous matrix components influence the micromechanical environment of tenocytes within tendon fascicles subjected to tensile strain.
Bader DL, Shelton JC, Lee DA and SCREEN HRC
Eur. Cells Mat. vol. 4:S1, 41-42.  
01-01-2002

2001

Characterization of Lenslet Arrays for Astronomical Spectroscopy
Lee D, Haynes R, Ren D and Allington‐Smith J
Publications of The Astronomical Society of The Pacific, Iop Publishing vol. 113 (789), 1406-1419.  
08-10-2001
Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine (2000) Edited by Johnny Huard and Freddie H. Fu, ISBN 0-8176-4071-1, Birkhauser: Boston pages 1–286
Bader D and Lee D
Medical Engineering & Physics, Elsevier vol. 23 (8) 
01-10-2001
Properties of optical fibres at cryogenic temperatures
Lee D, Haynes R and Skeen DJ
Monthly Notices of The Royal Astronomical Society, Oxford University Press (Oup) vol. 326 (2), 774-780.  
01-09-2001
The early-type galaxy population in Abell 2218
Ziegler BL, Bower RG, Smail I, Davies RL and Lee D
Monthly Notices of The Royal Astronomical Society, Oxford University Press (Oup) vol. 325 (4), 1571-1590.  
21-08-2001
Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs.
Chowdhury TT, Bader DL and Lee DA
Biochem Biophys Res Commun vol. 285 (5), 1168-1174.  
03-08-2001
Effects of Tissue Transglutaminase on Retinoic Acid-induced Cellular Differentiation and Protection against Apoptosis*
Antonyak MA, Singh US, Lee DA, Boehm JE, Combs C, Zgola MM, Page RL and Cerione RA
Journal of Biological Chemistry, Elsevier vol. 276 (36), 33582-33587.  
03-07-2001
Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose.
Knight MM, Ross JM, Sherwin AF, Lee DA, Bader DL and Poole CA
Biochim Biophys Acta vol. 1526 (2), 141-146.  
03-05-2001
Temporal changes in cytoskeletal organisation within isolated chondrocytes quantified using a novel image analysis technique.
Knight MM, Idowu BD, Lee DA and Bader DL
Med Biol Eng Comput vol. 39 (3), 397-404.  
01-05-2001
Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs.
Roberts SR, Knight MM, Lee DA and Bader DL
J Appl Physiol (1985) vol. 90 (4), 1385-1391.  
01-04-2001
Compressive deformation and damage of muscle cell subpopulations in a model system.
Bouten CV, Knight MM, Lee DA and Bade DL
Ann Biomed Eng vol. 29 (2), 153-163.  
01-02-2001
Compressive deformation and damage of muscle cell subpopulaltions in a model system
Bader DL, KNIGHT MM, Lee DA and Bouten CV
Ann. Biomed. Eng. vol. 29 (2), 153-163.  
01-01-2001
Embryonic stem cells: scientific possibilities, ethical considerations, and regulation in the UK
Lee DA
Interdiscipl Sci Rev vol. 26 (2), 112-124.  
01-01-2001
VIDA: a virus database system for the organization of animal virus genome open reading frames
Albà MM, Lee D, Pearl FMG, Shepherd AJ, Martin N, Orengo CA and Kellam P
Nucleic Acids Research, Oxford University Press (Oup) vol. 29 (1), 133-136.  
01-01-2001
A rapid classification protocol for the CATH Domain Database to support structural genomics
Pearl FM, Martin N, Bray JE, Buchan DW, Harrison AP, Lee D, Reeves GA, Shepherd AJ, Sillitoe I, Todd AE, Thornton JM and Orengo CA
Nucleic Acids Research, Oxford University Press (Oup) vol. 29 (1), 223-227.  
01-01-2001

2000

Biological response of cyclic strain on developed cell seeded collagen gel model
Berry CC, Cacou C, Shelton JC, Bader DL and Lee DA
Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell 
01-12-2000
Physiochemical, biochemical and mechanical characterisation of chondrocyte-alginate constructs
Enobakhare BO, Bader DL and Lee DA
Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell 
01-12-2000
Dynamic compression inhibits the synthesis of nitric oxide by IL-1β stimulated chondrocytes cultured in agarose constructs
Chowdhury TT, Bader DL and Lee DA
Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell 
01-12-2000
A system for monitoring the response of uniaxial strain on cell seeded collagen gels
Cacou C, Palmer D, Lee DA, Bader DL and Shelton JC
Med Eng Phys vol. 22 (5), 327-333.  
01-06-2000
Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose.
Idowu BD, Knight MM, Bader DL and Lee DA
Histochem J vol. 32 (3), 165-174.  
01-03-2000
An experimental investigation of immersed gratings
Lee D and Allington-Smith JR
Monthly Notices of The Royal Astronomical Society, Oxford University Press (Oup) vol. 312 (1), 57-69.  
11-02-2000
Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels.
Lee DA, Knight MM, Bolton JF, Idowu BD, Kayser MV and Bader DL
J Biomech vol. 33 (1), 81-95.  
01-01-2000
The influence of mechanical loading on isolated chondrocytes seeded in agarose constructs.
Lee DA, Noguchi T, Frean SP, Lees P and Bader DL
Biorheology vol. 37 (1-2), 149-161.  
01-01-2000
Assigning genomic sequences to CATH
Pearl FM, Lee D, Bray JE, Sillitoe I, Todd AE, Harrison AP, Thornton JM and Orengo CA
Nucleic Acids Research, Oxford University Press (Oup) vol. 28 (1), 277-282.  
01-01-2000
Chapter 4 Structure – Properties of Soft Tissues Articular Cartilage
Bader D and Lee D
In Structural Biological Materials - Design and Structure-Property Relationships, Elsevier 75-103.  
01-01-2000

1999

Transcriptional repression of the transforming growth factor-β type I receptor gene by DNA methylation results in the development of TGF-β resistance in human gastric cancer
Kang SH, Bang Y-J, Im Y-H, Yang H-K, Lee DA, Lee HY, Lee HS, Kim NK and Kim S-J
Oncogene, Springer Nature vol. 18 (51), 7280-7286.  
02-12-1999
Models of government regulation of privatized transit systems in five Latin American cities
Lee DA
Transportation Quarterly vol. 53 (1), 21-39.  
01-12-1999
Multiple‐Object and Integral Field Near‐Infrared Spectroscopy Using Fibers
Haynes R, Lee D, Allington‐Smith J, Content R, Dodsworth G, Lewis I, Sharples R, Turner J, Webster J, Done C, Peletier R, Parry I and Chapman S
Publications of The Astronomical Society of The Pacific, Iop Publishing vol. 111 (765), 1451-1468.  
01-11-1999
The effects of storage temperature on the composition, metabolism acid biomechanical properties of human articular cartilage
White AET, Bentley G, Stephens MD, Bader DL, Giddins GEB and Lee DA
Knee vol. 6 (3), 197-205.  
01-08-1999
Introducing Fare Simplification and New Convenience Fares at Connecticut Transit
Lee DA
Transportation Research Record Journal of The Transportation Research Board, Sage Publications vol. 1669 (1), 109-112.  
01-01-1999

1998

A Tour through through
Lee D
Journal of English Linguistics, Sage Publications vol. 26 (4), 333-351.  
01-12-1998
Response of chondrocyte subpopulations cultured within unloaded and loaded agarose.
Lee DA, Noguchi T, Knight MM, O'Donnell L, Bentley G and Bader DL
J Orthop Res vol. 16 (6), 726-733.  
01-11-1998
The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose.
Knight MM, Lee DA and Bader DL
Biochim Biophys Acta vol. 1405 (1-3), 67-77.  
21-10-1998
Dynamic mechanical compression influences nitric oxide production by articular chondrocytes seeded in agarose
Lee DA, Frean SP, Lees P and Bader DL
Biochem Bioph Res Co vol. 251 (2), 580-585.  
20-10-1998
The pH-Induced Release of Iron from Transferrin Investigated with a Continuum Electrostatic Model
Lee DA and Goodfellow JM
Biophysical Journal, Elsevier vol. 74 (6), 2747-2759.  
01-06-1998
Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression.
Knight MM, Ghori SA, Lee DA and Bader DL
Med Eng Phys vol. 20 (9), 684-688.  
01-01-1998
A specific quantitative assay for collagen synthesis by cells seeded in collagen-based biomaterials using sirius red F3B precipitation
Lee DA, Assoku E and Doyle V
J Mater Sci-Mater M vol. 9 (1), 47-51.  
01-01-1998
Erratum: Use of polymerase chain reaction to provide prognostic information on human cytomegalovirus disease after liver transplantation. (Journal of Medical Virology 51 (152-158))
Lao WC, Lee D, Burroughs AK, Lanzani G, Rolles K, Emery VC and Griffiths PD
Journal of Medical Virology vol. 54 (1) 
01-01-1998

1997

Effect of Normal Synovial Fluid on the Metabolism of Articular Chondrocytes In Vitro
Lee DA, Salih V, Stockton EF, Stanton JS and Bentley G
Clinical Orthopaedics and Related Research®, Wolters Kluwer vol. 342 (&NA;), 228-238.  
01-09-1997
Quantitative Evaluation of the Exploration Strategies of a Mobile Robot
Lee D and Recce M
The International Journal of Robotics Research, Sage Publications vol. 16 (4), 413-447.  
01-08-1997
Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose
Lee DA and Bader DL
J Orthop Res vol. 15 (2), 181-188.  
01-03-1997
Prevalence of anti‐Vif antibodies in HIV‐1 infected individuals assessed using recombinant baculovirus expressed Vif protein
O'Neil C, Lee D, Clewley G, Johnson MA and Emery VC
Journal of Medical Virology, Wiley vol. 51 (3), 139-144.  
01-03-1997
Frame conflicts and competing construals in family argument
Lee DA
Journal of Pragmatics, Elsevier vol. 27 (3), 339-360.  
01-03-1997
Use of polymerase chain reaction to provide prognostic information on human cytomegalovirus disease after liver transplantation
Lao WC, Lee D, Burroughs AK, Lanzini G, Rolles K, Emery VC and Griffiths PD
Journal of Medical Virology, Wiley vol. 51 (3), 152-158.  
01-03-1997

1996

Preliminary Results From the Cancer Research Campaign Trial Evaluating Tamoxifen Duration in Women Aged Fifty Years or Older With Breast Cancer
Group CTWPOTCRCBCT
Journal of The National Cancer Institute, Oxford University Press (Oup) vol. 88 (24), 1834-1839.  
18-12-1996
Quantification of sulfated glycosaminoglycans in chondrocyte/alginate cultures, by use of 1,9-dimethylmethylene blue
Enobakhare BO, Bader DL and Lee DA
Anal Biochem vol. 243 (1), 189-191.  
01-12-1996
J. Virol. Methods Erratum to “Detection of human cytomegalovirus polymerase chain reaction products using oligonucleotide probes directly conjugated to alkaline phosphatase” [61 (1996) 145]
Gor D, Lee D and Emery VC
Journal of Virological Methods, Elsevier vol. 62 (2) 
01-12-1996
Detection of human cytomegalovirus polymerase chain reaction products using oligonucleotide probes directly conjugated to alkaline phosphatase
Gor D, Lee D and Emery VC
Journal of Virological Methods, Elsevier vol. 61 (1-2), 145-150.  
01-09-1996
An investigation of the growth of human dermal fibroblasts on poly-L-lactic acid in vitro
Doyle V, Pearson R, Lee D, Wolowacz S and Mc Taggart S
Journal of Materials Science: Materials in Medicine, Springer Nature vol. 7 (6), 381-385.  
01-06-1996
Conformational analysis of pentapeptide sequences matching a proposed recognition motif for lysosomal degradation
Gorinsky B, Laskowski RA, Lee DA and Bomford A
Biochimica Et Biophysica Acta, Elsevier vol. 1293 (2), 243-253.  
01-04-1996
Implementing a Visioning and Strategic Planning Process at CTTransit
Lee D and Sanders M
Transportation Research Record Journal of The Transportation Research Board, Sage Publications vol. 1521, 58-61.  
01-01-1996

1995

The development and characterization of an in vitro system to study strain-induced cell deformation in isolated chondrocytes
Lee DA and Bader DL
In Vitro Cell Dev-An vol. 31 (11), 828-835.  
01-12-1995

1994

Proteoglycan depletion alone is not sufficient to stimulate proteoglycan synthesis in cultured bovine cartilage explants
Lee DA, Bentley G and Archer CW
Osteoarthritis and Cartilage, Elsevier vol. 2 (3), 175-185.  
01-09-1994
Characterization of the repair tissue in articular cartilage defects using silver-enhanced colloidal gold immunostaining
Reissis N, Downes S, Kayser M, Lee D and Bentley G
Journal of Materials Science: Materials in Medicine, Springer Nature vol. 5 (6-7), 402-406.  
01-06-1994

1993

The control of cell division in articular chondrocytes
Lee DA, Bentley G and Archer CW
Osteoarthritis and Cartilage, Elsevier vol. 1 (2), 137-145.  
01-04-1993

1991

Categories in the description of just
Lee DA
Lingua, Elsevier vol. 83 (1), 43-66.  
01-01-1991

1990

Effects of ascorbate on myogenesis in micromass culture
Archer CW, Cottrill CP and Lee D
In Vitro Cellular & Developmental Biology, Springer Nature vol. 26 (3), 259-264.  
01-03-1990
Digitization of the AT&T worldwide intelligent network
Lee DA
At&Amp;T Technology vol. 5 (1), 14-19.  
01-01-1990

1989

Relation between the rate of cell movement under agarose and the positioning of cells in heterotypic aggregates
Jones BM, Evans PM and Lee DA
Experimental Cell Research, Elsevier vol. 180 (1), 287-296.  
01-01-1989

1988

INTEGRATED SERVICES DIGITAL NETWORK.
Lee D
British Telecommunications Engineering vol. 7 (pt 2), 2-12.  
01-07-1988
Moth Density and Oviposition Patterns of the European Corn Borer, Ostrinia nubilalis (Lepidoptera: Pyralidae), in Alberta
Lee DA
Environmental Entomology, Oxford University Press (Oup) vol. 17 (2), 220-224.  
01-04-1988

1987

Reproductive patterns of the European corn borer (Ostrinia nubilalis) in Alberta
Lee DA and Spence JR
Canadian Journal of Zoology, Canadian Science Publishing vol. 65 (7), 1733-1740.  
01-07-1987
The semantics of just
Lee D
Journal of Pragmatics, Elsevier vol. 11 (3), 377-398.  
01-06-1987

1983

Prevalence and spectrum of asthma in childhood.
Lee DA, Winslow NR, Speight AN and Hey EN
The Bmj, Bmj vol. 286 (6373) 
16-04-1983
Underdiagnosis and undertreatment of asthma in childhood.
Speight AN, Lee DA and Hey EN
The Bmj, Bmj vol. 286 (6373) 
16-04-1983

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconClock-Chips - Incorporating the Circadian Clock into Organ-on-a-Chip Technology
David Lee and Lei Su
£387,326 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2024 - 31-03-2026
solid heart iconEPSRC Centre for Doctoral Training in Next Generation Organ-on-a-Chip Technology (COaCT)
Hazel Screen, Martin Knight, Thomas Iskratsch, Caroline Roney, Yi Sui, David Lee, Julia Shelton, Zion Tse, John Connelly, Adrian Biddle and Lucy Norling
£7,066,811 EPSRC Engineering and Physical Sciences Research Council 
Grant Summary

01-07-2024 - 30-09-2032
bullet iconHarmonised IAA grant - Improve and accelerate the impact of QMUL research BBSRC
David Lee and Viji Draviam Sastry
£495,000 BBSRC Biotechnology and Biological Sciences Research Council
01-04-2022 - 31-03-2026
bullet iconHarmonised IAA grant - Improve and accelerate the impact of QMUL research EPSRC
David Lee and Yang Hao
£882,583 EPSRC Engineering and Physical Sciences Research Council
01-04-2022 - 31-03-2026
bullet iconHarmonised IAA grant - Improve and accelerate the impact of QMUL research MRC
Mauro Perretti, Tatjana Crnogorac-Jurcevic and David Lee
£457,000 MRC Medical Research Council
01-04-2022 - 31-03-2026

bullet iconEngineering Circadian Biology into Human Induced Pluripotent Stem Cell Organ-on-a-Chip models
David Lee and Yung-Yao Lin
£201,874 BBSRC Biotechnology and Biological Sciences Research Council
01-02-2022 - 31-01-2025
bullet iconSuper-Resolution Microscopy of live cells in 3D
Viji Draviam Sastry, Conrad Mullineaux, Vidya Darbari, Lakxmi Subramanian, Fabrice Caudron, Richard Pickersgill, Guy Hanke, Alexander Ruban, Peter Thorpe, Christopher Duffy, Jose Martin Duran, John Connelly, Peter McCormick, Paul Chapple, Vardhman Rakyan, Tyson Sharp, Susana Godinho and David Lee
£369,201 BBSRC Biotechnology and Biological Sciences Research Council
01-12-2020 - 31-03-2022
bullet iconDoes the biological clock within cartilage align to diurnal patterns in activity?
David Lee, Hannah Heywood and Martin Knight
£9,954 EPSRC Engineering and Physical Sciences Research Council
01-10-2019 - 31-10-2020
bullet iconMecho-Regulation of Genome Function
David Lee
£436,194 BBSRC Biotechnology and Biological Sciences Research Council
01-01-2017 - 31-12-2019