Wiesheu R, Edwards SC, Hedley A, Hall H, Tosolini M, Fares da Silva MGF, Sumaria N, Castenmiller SM, Wardak L, Optaczy Y, Lynn A, Hill DG, Hayes AJ, Hay J, Kilbey A, Shaw R, Whyte D, Walsh PJ, Michie AM, Graham GJ, Manoharan A, Halsey C, Blyth K, Wolkers MC, Miller C, Pennington DJ, Jones GW, Fournie J-J, Bekiaris V and Coffelt SB (2024). IL-27 maintains cytotoxic Ly6C+ γδ T cells that arise from immature precursors. Springer Nature  The EMBO Journal  vol. 43, (14) 2878-2907.  

Sumaria N, Fiala GJ, Inácio D, Curado-Avelar M, Cachucho A, Pinheiro R, Wiesheu R, Kimura S, Courtois L, Blankenhaus B, Darrigues J, Suske T, Almeida ARM, Minguet S, Asnafi V, Lhermitte L, Mullighan CG, Coffelt SB, Moriggl R, Barata JT, Pennington DJ and Silva-Santos B (2024). Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R–STAT5B-driven neoplasms. Springer Nature  Nature Immunology  vol. 25, (7) 1207-1217.  

Hirani P, McDermott J, Rajeeve V, Cutillas PR, Jones JL, Pennington DJ, Wight TN, Santamaria S, Alonge KM and Pearce OMT (2024). Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate. American Association for Cancer Research (AACR)  Cancer Research Communications  vol. 4, (4) 970-985.  

Murtough S, Babu D, Webb CM, Picard HLD, McGinty LA, Chao-Chu J, Pink R, Silver AR, Smart HL, Field JK, Woodland P, Risk JM, Blaydon DC, Pennington DJ and Kelsell DP (2023). Investigating iRHOM2-Associated Transcriptional Changes in Tylosis With Esophageal Cancer. Elsevier  Gastro Hep Advances  vol. 3, (3) 385-395.  

Hindle S, Taggart E, Blowes L, Pennington D, Singh B, Caley M and Connelly J (2023). 1035 Understanding dynamic immune responses within a 3D microfluidic model of human skin. Elsevier  Journal of Investigative Dermatology  vol. 143, (5)  

Mann BT, Sanz M, Ryan P, Bosque A, Pennington D, Hackstein H and Soriano-Sarabia N (2023). Deep Characterization of Human γδ T Cell Subsets Defines Lineage-Specific Traits. The American Association of Immunologists  The Journal of Immunology  vol. 210, (1_Supplement) 167.15-167.15.  

Hirani P, Alonge KM, Pennington DJ, Cutillas PR, Wight TN and Pearce OM (2023). Abstract 5841: Exploring the role of versican in immune exclusion within triple negative breast cancer. American Association for Cancer Research (AACR)  Cancer Research  vol. 83, (7_Supplement) 5841-5841.  

Sanz M, Mann BT, Ryan PL, Bosque A, Pennington DJ, Hackstein H and Soriano-Sarabia N (2023). Deep characterization of human γδ T cell subsets defines shared and lineage-specific traits. Frontiers  Frontiers in Immunology  vol. 14,  

Murtough S, Ramos Del Caño L, Delaney P, Webb C, Colom B, Jones P, Blaydon D, Kelsell D, Babu D and Pennington D (2022). ESDR173 - A Model to Unravel Pathways Underpinning Palmoplantar Homeostasis and Disease. Morressier   

Anene CA, Taggart E, Harwood CA, Pennington DJ and Wang J (2022). Decosus: An R Framework for Universal Integration of Cell Proportion Estimation Methods. Frontiers  Frontiers in Genetics  vol. 13,  

Pennington D, Sumaria N and Martin S (2021). Constrained TCRγδ-associated Syk activity engages PI3K to facilitate thymic development of IL-17A–secreting γδ T cells. American Association for the Advancement of Science  Science Signaling   

Ng KE, Delaney PJ, Thenet D, Murtough S, Webb CM, Zaman N, Tsisanova E, Mastroianni G, Walker SLM, Westaby JD, Pennington DJ, Pink R, Kelsell DP and Tinker A (2021). Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathy. Springer Nature  Cell and Tissue Research  vol. 386, (1) 79-98.  

Park JE, JebaMercy G, Pazhanchamy K, Guo X, Ngan SC, Liou KCK, Lynn SE, Ng SS, Meng W, Lim SC, Leow MK-S, Richards AM, Pennington DJ, de Kleijn DPV, Sorokin V, Ho HH, McCarthy NE and Sze SK (2021). Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis. Elsevier  Atherosclerosis  vol. 324, 58-68.  

Pennington D, Lynch L, Silva-Santos B, Lopes N, McIntyre C, Martin S, Sumaria N and Raverdeau M (2021). Distinct metabolic programmes established in the thymus control effector functions of gd T cell subsets in tumour microenvironments. Nature Research  Nature Immunology  179-192.  

Galson JD, Schaetzle S, Bashford-Rogers RJM, Raybould MIJ, Kovaltsuk A, Kilpatrick GJ, Minter R, Finch DK, Dias J, James LK, Thomas G, Lee W-YJ, Betley J, Cavlan O, Leech A, Deane CM, Seoane J, Caldas C, Pennington DJ, Pfeffer P and Osbourn J (2020). Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures. Frontiers  Frontiers in Immunology  vol. 11,  

Clohosey ML, Mann BT, Ryan PL, Apanasovich TV, Maggirwar SB, Pennington DJ and Soriano-Sarabia N (2020). Comparable Vδ2 Cell Functional Characteristics in Virally Suppressed People Living with HIV and Uninfected Individuals. MDPI  Cells  vol. 9, (12)  

Chao-Chu J, Murtough S, Zaman N, Pennington DJ, Blaydon DC and Kelsell DP (2020). iRHOM2: A Regulator of Palmoplantar Biology, Inflammation, and Viral Susceptibility. Elsevier  Journal of Investigative Dermatology  vol. 141, (4) 722-726.  

Galson JD, Schaetzle S, Bashford-Rogers RJM, Raybould MIJ, Kovaltsuk A, Kilpatrick GJ, Minter R, Finch DK, Dias J, James L, Thomas G, Lee W-YJ, Betley J, Cavlan O, Leech A, Deane CM, Seoane J, Caldas C, Pennington D, Pfeffer P and Osbourn J (2020). Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures. Cold Spring Harbor Laboratory   

Edelblum K, Gustafsson K, Pennington DJ, Willcox BE and Ribot JC (2019). Bordeaux 2018: Wine, Cheese, and γδ T Cells. Frontiers  Frontiers in Immunology  vol. 10,  

Webb C, Murtough S, Chikh A, Picard HLD, Wang J, Pink R, Risk JM, Fitzgerald RC, Pennington DJ and Kelsell DP (2019). 454 iRhom2-mediated immune dysregulation: Impact on the skin and oesophagus. Elsevier  Journal of Investigative Dermatology  vol. 139, (5)  

Sumaria N, Martin S and Pennington DJ (2019). Developmental origins of murine γδ T‐cell subsets. Wiley  Immunology  vol. 156, (4) 299-304.  

Grandjean CL, Sumaria N, Martin S and Pennington DJ (2017). Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ(+)CD8αα(+) intraepithelial lymphocytes. Springer Nature  Scientific Reports  vol. 7, (1)  

CABRERA CP, MANSON J, SHEPHERD JM, TORRANCE HD, WATSON D, LONGHI MP, HOTI M, PATEL MB, O'DWYER M, NOURSHARGH S, PENNINGTON DJ, BARNES MR and BROHI K (2017). Signatures of Inflammation and Impending Multiple Organ Dysfunction in the Hyperacute Phase of Trauma. Public Library of Science (PLoS)  PLoS Medicine   

Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB, O'Dwyer M, Nourshargh S, Pennington DJ, Barnes MR and Brohi K (2017). Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study. PLoS Med  vol. 14, (7)  

Sumaria N, Grandjean CL, Silva-Santos B and Pennington DJ (2017). Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells. Cell Press  Cell Rep  vol. 19, (12) 2469-2476.  

Muñoz-Ruiz M, Sumaria N, Pennington DJ and Silva-Santos B (2017). Thymic Determinants of γδ T Cell Differentiation. Elsevier  Trends in Immunology  vol. 38, (5) 336-344.  

Fechter K, Dorronsoro A, Jakobsson E, Ferrin I, Lang V, Sepulveda P, Pennington DJ and Trigueros C (2017). IFNγ Regulates Activated Vδ2+ T Cells through a Feedback Mechanism Mediated by Mesenchymal Stem Cells. Public Library of Science  PLoS One  vol. 12, (1) e0169362-e0169362.  

Ryan PL, Sumaria N, Holland CJ, Bradford CM, Izotova N, Grandjean CL, Jawad AS, Bergmeier LA and PENNINGTON DJ (2016). Heterogeneous yet stable Vδ2(+) T cell profiles define distinct cytotoxic effector potentials in healthy human individuals. National Academy of Sciences  Proceedings of the National Academy of Sciences  vol. 113, (50) 14378-14383.  

Manson J, Cole E, De’Ath HD, Vulliamy P, Meier U, Pennington D and Brohi K (2016). Early changes within the lymphocyte population are associated with the development of multiple organ dysfunction syndrome in trauma patients. Critical Care  vol. 20, (1)  

Muñoz-Ruiz M, Ribot JC, Grosso AR, Gonçalves-Sousa N, Pamplona A, Pennington DJ, Regueiro JR, Fernández-Malavé E and Silva-Santos B (2016). TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets. Nature immunology   

Stoenchev KV and Pennington DJ (2016). Structure and Function of TCRγδ Receptors. Encyclopedia of Immunobiology  Elsevier   

Torrance H, Brohi K, Warnes G, Owen H, Hinds C, Pennington D and O'Dwyer M (2015). T-helper cell polarisation following severe polytrauma. Springer Nature  Intensive Care Medicine Experimental  vol. 3, (Suppl 1)  

Rei M, Pennington DJ and Silva-Santos B (2015). The Emerging Protumor Role of γδ T Lymphocytes: Implications for Cancer Immunotherapy. American Association for Cancer Research (AACR)  Cancer Research  vol. 75, (5) 798-802.  

Turner MD, Nedjai B, Hurst T and Pennington DJ (2014). Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. Biochim Biophys Acta  vol. 1843, (11) 2563-2582.  

Rei M, Gonçalves-Sousa N, Lança T, Thompson RG, Mensurado S, Balkwill FR, Kulbe H, Pennington DJ and Silva-Santos B (2014). Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages. Proc Natl Acad Sci U S A  vol. 111, (34) E3562-E3570.  

Dorronsoro A, Ferrin I, Salcedo JM, Jakobsson E, Fernández-Rueda J, Lang V, Sepulveda P, Fechter K, Pennington D and Trigueros C (2014). Human mesenchymal stromal cells modulate T-cell responses through TNF-α-mediated activation of NF-κB. Eur J Immunol  vol. 44, (2) 480-488.  

Schmolka N, Serre K, Grosso AR, Rei M, Pennington DJ, Gomes AQ and Silva-Santos B (2013). Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets. Nat Immunol  vol. 14, (10) 1093-1100.  

Prinz I, Silva-Santos B and Pennington DJ (2013). Functional development of γδ T cells. Eur J Immunol  vol. 43, (8) 1988-1994.  

Coquet JM, Ribot JC, Bąbała N, Middendorp S, van der Horst G, Xiao Y, Neves JF, Fonseca-Pereira D, Jacobs H, Pennington DJ, Silva-Santos B and Borst J (2013). Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway. J Exp Med  vol. 210, (4) 715-728.  

Michel M-L, Pang DJ, Haque SFY, Potocnik AJ, Pennington DJ and Hayday AC (2012). Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing γδ cells. Proc Natl Acad Sci U S A  vol. 109, (43) 17549-17554.  

Pang DJ, Neves JF, Sumaria N and Pennington DJ (2012). Understanding the complexity of γδ T-cell subsets in mouse and human. Immunology  vol. 136, (3) 283-290.  

Turchinovich G and Pennington DJ (2011). T cell receptor signalling in γδ cell development: strength isn't everything. Trends Immunol  vol. 32, (12) 567-573.  

Mahtani-Patching J, Neves JF, Pang DJ, Stoenchev KV, Aguirre-Blanco AM, Silva-Santos B and Pennington DJ (2011). PreTCR and TCRγδ signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization. Sci Signal  vol. 4, (182)  

Cárcamo-Orive I, Gaztelumendi A, Delgado J, Tejados N, Dorronsoro A, Fernández-Rueda J, Pennington DJ and Trigueros C (2010). Regulation of human bone marrow stromal cell proliferation and differentiation capacity by glucocorticoid receptor and AP-1 crosstalk. J Bone Miner Res  vol. 25, (10) 2115-2125.  

Afifi A, Raja SG, Pennington DJ and Tsang VT (2010). For neonates undergoing cardiac surgery does thymectomy as opposed to thymic preservation have any adverse immunological consequences? Interact Cardiovasc Thorac Surg  vol. 11, (3) 287-291.  

Sengupta N, MacFie TS, MacDonald TT, Pennington D and Silver AR (2010). Cancer immunoediting and spontaneous tumor regression. Pathol Res Pract  vol. 206, (1) 1-8.  

Ribot JC, deBarros A, Pang DJ, Neves JF, Peperzak V, Roberts SJ, Girardi M, Borst J, Hayday AC, Pennington DJ and Silva-Santos B (2009). CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets. Nat Immunol  vol. 10, (4) 427-436.  

McKnight A and Pennington DJ (2009). HIV Vaccine Approaches. Encyclopedia of Life Sciences  John Wiley & Sons, Ltd: Chichester.   

Sancho D, Mourão-Sá D, Joffre OP, Schulz O, Rogers NC, Pennington DJ, Carlyle JR and Reis e Sousa C (2008). Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. J Clin Invest  vol. 118, (6) 2098-2110.  

Hunt KA, Zhernakova A, Turner G, Heap GAR, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GKT, Howdle PD, Walters JRF, Sanders DS, Playford RJ, Trynka G, Mulder CJJ, Mearin ML, Verbeek WHM, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP and McArdle WL (2008). Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet  vol. 40, (4) 395-402.  

Hayday AC and Pennington DJ (2007). Key factors in the organized chaos of early T cell development. Nat Immunol  vol. 8, (2) 137-144.  

Pennington DJ, Silva-Santos B, Silberzahn T, Escorcio-Correia M, Woodward MJ, Roberts SJ, Smith AL, Dyson PJ and Hayday AC (2006). Early events in the thymus affect the balance of effector and regulatory T cells. NATURE  vol. 444, (7122) 1073-1077.  

Pennington DJ, Silva-Santos B, Correia M and Hayday AC (2005). The regulation of gamma delta cell functional potential by alpha alpha beta T cell progenitors in the thymus. IMMUNOLOGY  vol. 116, 88-88.  

Pennington DJ, Silva-Santos B and Hayday AC (2005). Gammadelta T cell development--having the strength to get there. Curr Opin Immunol  vol. 17, (2) 108-115.  

Silva-Santos B, Pennington DJ and Hayday AC (2005). Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors. Science  vol. 307, (5711) 925-928.  

Pennington DJ, Vermijlen D, Wise EL, Clarke SL, Tigelaar RE and Hayday AC (2005). The integration of conventional and unconventional T cells that characterizes cell-mediated responses. Adv Immunol  vol. 87, 27-59.  

Comalada M, Xaus J, Valledor AF, López-López C, Pennington DJ and Celada A (2003). PKC epsilon is involved in JNK activation that mediates LPS-induced TNF-alpha, which induces apoptosis in macrophages. Am J Physiol Cell Physiol  vol. 285, (5) C1235-C1245.  

Pennington DJ, Silva-Santos B, Shires J, Theodoridis E, Pollitt C, Wise EL, Tigelaar RE, Owen MJ and Hayday AC (2003). The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells. Nat Immunol  vol. 4, (10) 991-998.  

Hayday AC, Pennington DJ and Giuggio VM (2003). Genomics and immunology. Semin Immunol  vol. 15, (4) 201-208.  

Trigueros C, Hozumi K, Silva-Santos B, Bruno L, Hayday AC, Owen MJ and Pennington DJ (2003). Pre-TCR signaling regulates IL-7 receptor alpha expression promoting thymocyte survival at the transition from the double-negative to double-positive stage. Eur J Immunol  vol. 33, (7) 1968-1977.  

Aliberti J, Schulz O, Pennington DJ, Tsujimura H, Reis e Sousa C, Ozato K and Sher A (2003). Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells. Blood  vol. 101, (1) 305-310.  

Saurin AT, Pennington DJ, Raat NJH, Latchman DS, Owen MJ and Marber MS (2002). Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts. Cardiovasc Res  vol. 55, (3) 672-680.  

Leask A, Abraham DJ, Finlay DR, Holmes A, Pennington D, Shi-Wen X, Chen Y, Venstrom K, Dou X, Ponticos M, Black C, Bernabeu C, Jackman JK, Findell PR and Connolly MK (2002). Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts. Arthritis Rheum  vol. 46, (7) 1857-1865.  

Schulz O, Pennington DJ, Hodivala-Dilke K, Febbraio M and Reis e Sousa C (2002). CD36 or alphavbeta3 and alphavbeta5 integrins are not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha+ murine dendritic cells. J Immunol  vol. 168, (12) 6057-6065.  

Holmes A, Shi-Wen X, Ponticos M, Rajkumar V, Pennington D, Mukerjee D, Abraham DJ and Black CM (2002). CONNECTIVE TISSUE GROWTH FACTOR PRODUCED BY LUNG FIBROBLASTS IN RESPONSE TO INJURY MEDIATES EXTRACELLULAR MATRIX DEPOSITION IN BLEOMYCIN-INDUCED LUNG FIBROSIS. RHEUMATOLOGY  vol. 41, 58-58.  

Castrillo A, Pennington DJ, Otto F, Parker PJ, Owen MJ and Boscá L (2001). Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection. J Exp Med  vol. 194, (9) 1231-1242.  

Saurin AT, Pennington DJ, Raat H, Owen MJ and Marber MS (2000). Ischemic preconditioning in isolated mouse hearts - An essential role for PKC-epsilon. CIRCULATION  vol. 102, (18) 155-155.  

Shi-wen X, Pennington D, Holmes A, Leask A, Bradham D, Beauchamp JR, Fonseca C, du Bois RM, Martin GR, Black CM and Abraham DJ (2000). Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis. Exp Cell Res  vol. 259, (1) 213-224.  

Buckland J, Pennington DJ, Bruno L and Owen MJ (2000). Correction: Co-ordination of the expression of the protein tyrosine kinase p56(lck) with the pre-T cell receptor during thymocyte development (European Journal of Immunology) (2000) 30, 1 (8-18)). European Journal of Immunology  vol. 30, (3)  

Buckland J, Pennington DJ, Bruno L and Owen MJ (2000). Co-ordination of the expression of the protein tyrosine kinase p56(lck) with the pre-T cell receptor during thymocyte development. Eur J Immunol  vol. 30, (1) 8-18.  

Holmes A, Fonseca C, Pennington D, Shiwen X, Rajkumar V, Black C and Abraham D (1999). Identification of over expressed genes involved in the maintance of fibrosis: representational difference analysis of scleroderma fibroblasts. ARTHRITIS RHEUM  vol. 42, (9) S203-S203.  

Pennington DJ, Jenkins SA, Brady HJ, Miles CG, Dzierzak EA and Abraham DJ (1997). HIV- I Nef severely impairs thymocyte development and peripheral T-cell function by a CD4-independent mechanism. Genes Funct  vol. 1, (5-6) 321-335.  

Brady HJ, Abraham DJ, Pennington DJ, Miles CG, Jenkins S and Dzierzak EA (1995). Altered cytokine expression in T lymphocytes from human immunodeficiency virus Tat transgenic mice. J Virol  vol. 69, (12) 7622-7629.  

ABRAHAM D, PENNINGTON D, MILES C, JENKINS S, BRADY H and DZIERZAK E (1995). T-CELLS FROM HIV-1 TAT TRANSGENIC MICE SHOW ALTERED CYTOKINE EXPRESSION. J CELL BIOCHEM  200-200.  

Brady HJ, Pennington DJ and Dzierzak EA (1994). Transgenic mice as models of human immunodeficiency virus expression and related cellular effects. J Gen Virol  vol. 75 ( Pt 10), 2549-2558.  

Brady HJ, Miles CG, Pennington DJ and Dzierzak EA (1994). Specific ablation of human immunodeficiency virus Tat-expressing cells by conditionally toxic retroviruses. Proc Natl Acad Sci U S A  vol. 91, (1) 365-369.  

Brady HJ, Pennington DJ, Miles CG and Dzierzak EA (1993). CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration. EMBO J  vol. 12, (13) 4923-4932.  

Brady HJ, Miles CG, Pennington DJ and Dzierzak EA (1993). Studies of HIV-2 promoter activity and cell specific ablation. Leukemia  vol. 7 Suppl 2, S61-S65.  

DZIERZAK EA, MILES C, PENNINGTON D and BRADY HJM (1993). SPECIFIC ABLATION OF HIV-TAT EXPRESSING CELLS BY CONDITIONALLY TOXIC RETROVIRUSES. J CELL BIOCHEM  249-249.