Dr Ezra Aksoy

Ezra Aksoy
PhD, MSc, BSc, FHEA

Lecturer

The William Harvey Research Institute
Queen Mary University of London

Research

intestinal immunity, intestinal repair and regeneration, host-microbiome interactions, nutrient sensing pathways, phosphoinositol 3-kinase biology, inflammasome

Infectious Disease and Inflammation Models

Interests

Our group is seeking cell signalling targets as biomarkers in immune and epithelial cells in the intestine that impact immune inflammation and regeneration processes. We use in vitro and ex vivo models to test and identify new drug targets associated with process driven inflammation and immune responses.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2021

Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation
Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS, Gonzalez-Nuñez M, Austin-Williams SN, Cooper D, Vázquez-Martínez L, Fu T, De Rossi G, Golding M, Voisin M-B, Boulanger CM, Kubota Y, Muller WA, Tooze SA, Nightingale TD, Collinson L, Perretti M, Aksoy E and Nourshargh S
Immunity, Elsevier vol. 54 (9), 1989-2004.e9.  
06-08-2021
Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
Thibault B, Ramos‐Delgado F, Pons‐Tostivint E, Therville N, Cintas C, Arcucci S, Cassant‐Sourdy S, Reyes‐Castellanos G, Tosolini M, Villard AV, Cayron C, Baer R, Bertrand‐Michel J, Pagan D, Ferreira Da Mota D, Yan H, Falcomatà C, Muscari F, Bournet B, Delord J, Aksoy E, Carrier A, Cordelier P, Saur D, Basset C and Guillermet‐Guibert J
Embo Molecular Medicine, Springer Nature vol. 13 (7) 
25-05-2021

2020

From Welfare to Warfare: The Arbitration of Host-Microbiota Interplay by the Type VI Secretion System
Wood TE, Aksoy E and Hachani A
Frontiers in Cellular and Infection Microbiology, Frontiers vol. 10 
19-10-2020
Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus
Ferguson MS, Chard Dunmall LS, Gangeswaran R, Marelli G, Tysome JR, Burns E, Whitehead MA, Aksoy E, Alusi G, Hiley C, Ahmed J, Vanhaesebroeck B, Lemoine NR and Wang Y
Molecular Therapy, Elsevier (Cell Press) vol. 28 (5), 1263-1275.  
27-02-2020

2019

TLRs toll for Tregs
Aksoy E
Journal of Leukocyte Biology, Oxford University Press (Oup) vol. 106 (6), 1193-1195.  
17-09-2019
Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR
Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L, Molendi-Coste O, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte J-S, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K, Carmeliet P and Marot G
Cell, Elsevier vol. 177 (5), 1201-1216.e19.  
25-04-2019
Erratum: Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR (Cell (2019) 177(5) (1201–1216.e19), (S0092867419302806), (10.1016/j.cell.2019.03.018))
Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L, Molendi-Coste O, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte JS, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K, Carmeliet P and Marot G
Cell vol. 178 (1), 263-263.  
25-04-2019
Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation
Sun D, Stopka-Farooqui U, Barry S, Aksoy E, Parsonage G, Vossenkämper A, Capasso M, Wan X, Norris S, Marshall JL, Clear A, Gribben J, MacDonald TT, Buckley CD, Korbonits M and Haworth O
Cell Reports, Elsevier vol. 27 (5), 1461-1471.e4.  
01-04-2019

2018

The Isoform Selective Roles of PI3Ks in Dendritic Cell Biology and Function
Aksoy E, Saveanu L and Manoury B
Frontiers in Immunology, Frontiers Media Sa vol. 9 
15-11-2018

2015

Preventive and Therapeutic Effects of Lactobacillus Paracasei B21060–Based Synbiotic Treatment on Gut Inflammation and Barrier Integrity in Colitic Mice 1–3
Simeoli R, Mattace Raso G, Lama A, Pirozzi C, Santoro A, Di Guida F, Sanges M, Aksoy E, Calignano A, D'Arienzo A and Meli R
Journal of Nutrition, Elsevier vol. 145 (6), 1202-1210.  
29-04-2015

2014

NF‐κB Activation and Severity of Gastritis in Helicobacter pylori‐Infected Children and Adults
Bontems P, Aksoy E, Burette A, Segers V, Deprez C, Mascart F and Cadranel S
Helicobacter, Wiley vol. 19 (3), 157-167.  
24-03-2014

2013

Erratum: Corrigendum: The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock
Aksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno-Martin I, Nock G, Filloux A, Beyaert R, Flamand V and Vanhaesebroeck B
Nature Immunology, Springer Nature vol. 14 (8), 877-877.  
19-07-2013

2012

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock
Aksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno IM, Nock G, Filloux A, Beyaert R, Flamand V and Vanhaesebroeck B
Nature Immunology, Springer Nature vol. 13 (11), 1045-1054.  
30-09-2012
The p110´ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.
AKSOY-POISTER E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno IM, Nock G, Filloux A, Beyaert R, Flamand V and Vanhaesebroeck B
Nat Immunol. vol. 13 (11), 1045-1054.  
01-01-2012

2011

A conventional protein kinase C inhibitor targeting IRF-3-dependent genes differentially regulates IL-12 family members
Johnson J, Molle C, Aksoy E, Goldman M, Goriely S and Willems F
Molecular Immunology, Elsevier vol. 48 (12-13), 1484-1493.  
07-05-2011

2010

PKC‐α controls MYD88‐dependent TLR/IL‐1R signaling and cytokine production in mouse and human dendritic cells
Langlet C, Springael C, Johnson J, Thomas S, Flamand V, Leitges M, Goldman M, Aksoy E and Willems F
European Journal of Immunology, Wiley vol. 40 (2), 505-515.  
26-01-2010

2008

Toll-like Receptor Responses in Neonatal Dendritic Cells
Goriely S, Aksoy E, De Wit D, Goldman M and Willems F
In Hematology, Immunology and Infectious Disease: Neonatology Questions and Controversies 106-134.  
01-01-2008

2007

Protein Kinase Cα Is Involved in Interferon Regulatory Factor 3 Activation and Type I Interferon-β Synthesis*
Johnson J, Albarani V, Nguyen M, Goldman M, Willems F and Aksoy E
Journal of Biological Chemistry, Elsevier vol. 282 (20), 15022-15032.  
12-02-2007
An Alternative Pathway of NF-κB Activation Results in Maturation and T Cell Priming Activity of Dendritic Cells Overexpressing a Mutated IκBα
Moore F, Buonocore S, Aksoy E, Ouled-Haddou N, Goriely S, Lazarova E, Paulart F, Heirman C, Vaeremans E, Thielemans K, Goldman M and Flamand V
The Journal of Immunology, The American Association of Immunologists vol. 178 (3), 1301-1311.  
01-02-2007

2006

Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells
Aksoy E, Albarani V, Nguyen M, Laes J-F, Ruelle J-L, De Wit D, Willems F, Goldman M and Goriely S
Blood, American Society of Hematology vol. 109 (7), 2887-2893.  
30-11-2006

2005

Inhibition of phosphoinositide 3‐kinase enhances TRIF‐dependent NF‐κB activation and IFN‐β synthesis downstream of Toll‐like receptor 3 and 4
Aksoy E, Berghe WV, Detienne S, Amraoui Z, Fitzgerald KA, Haegeman G, Goldman M and Willems F
European Journal of Immunology, Wiley vol. 35 (7), 2200-2209.  
06-06-2005

2004

Double-stranded RNAs from the Helminth Parasite Schistosoma Activate TLR3 in Dendritic Cells*
Aksoy E, Zouain CS, Vanhoutte F, Fontaine J, Pavelka N, Thieblemont N, Willems F, Ricciardi-Castagnoli P, Goldman M, Capron M, Ryffel B and Trottein F
Journal of Biological Chemistry, Elsevier vol. 280 (1), 277-283.  
01-11-2004
CD40 expression on human pancreatic duct cells: role in nuclear factor-kappa B activation and production of pro-inflammatory cytokines
Vosters O, Beuneu C, Nagy N, Movahedi B, Aksoy E, Salmon I, Pipeleers D, Goldman M and Verhasselt V
Diabetologia, Springer Nature vol. 47 (4), 660-668.  
19-03-2004
Protein kinase C epsilon: a new target to control inflammation and immune-mediated disorders
Aksoy E, Goldman M and Willems F
The International Journal of Biochemistry & Cell Biology, Elsevier vol. 36 (2), 183-188.  
01-02-2004

2002

Critical role of protein kinase C ϵ for lipopolysaccharide‐induced IL‐12 synthesis in monocyte‐derived dendritic cells
Aksoy E, Amraoui Z, Goriely S, Goldman M and Willems F
European Journal of Immunology, Wiley vol. 32 (11), 3040-3049.  
16-10-2002
Bordetella pertussis toxin induces the release of inflammatory cytokines and dendritic cell activation in whole blood: impaired responses in human newborns
Tonon S, Goriely S, Aksoy E, Pradier O, Del Giudice G, Trannoy E, Willems F, Goldman M and De Wit D
European Journal of Immunology, Wiley vol. 32 (11), 3118-3125.  
16-10-2002
Monophosphoryl Lipid A Activates Both Human Dendritic Cells and T Cells
Ismaili J, Rennesson J, Aksoy E, Vekemans J, Vincart B, Amraoui Z, Van Laethem F, Goldman M and Dubois PM
The Journal of Immunology, The American Association of Immunologists vol. 168 (2), 926-932.  
15-01-2002

2001

Tumoricidal Activity of Monocyte-Derived Dendritic Cells: Evidence for a Caspase-8-Dependent, Fas-Associated Death Domain-Independent Mechanism
Vanderheyde N, Aksoy E, Amraoui Z, Vandenabeele P, Goldman M and Willems F
The Journal of Immunology, The American Association of Immunologists vol. 167 (7), 3565-3569.  
01-10-2001

2000

Expression of c-FLIP(L) and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide.
Willems F, Amraoui Z, Vanderheyde N, Verhasselt V, Aksoy E, Scaffidi C, Peter ME, Krammer PH and Goldman M
Blood, American Society of Hematology vol. 95 (11), 3478-3482.  
01-06-2000

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconUncovering selective role of PI3K signalling in antigen cross presentation in the phagosome
Ezra Aksoy
£11,630 Royal Society
01-04-2022 - 31-03-2025


bullet iconUnravelling Covid-19 immune responses in gut epithelium to target as potential site of immunisation
Ezra Aksoy
£10,000 February Foundation, The
01-08-2020 - 31-07-2021
bullet iconPI3K in gut immune-tolerance
Ezra Aksoy
£170,347 EU Commission - Horizon 2020
01-11-2019 - 14-11-2021
bullet iconGeneration of a new stratification strategy based on a new biomarker assay for IBD therapy
Ezra Aksoy
£49,704 Barts and the London Charity
16-09-2019 - 31-01-2022
bullet iconWilloughby Studentship
Ezra Aksoy
£86,094 Derek Willoughby Trustees, The
01-05-2018 - 31-10-2019
bullet iconSignalling-in-NODS - ‘Investigation of the role and mechanism of action of NOD2-mediated isoform selective PI3K signalling in gut immunity and inflammation’
Ezra Aksoy
£156,364 EU Commission - Horizon 2020
01-05-2017 - 30-04-2019
bullet iconThe role and mechanism of action of p110delta P13K signalling in gastrointedtinal immunity and inflammation
Ezra Aksoy
£551,150 MRC Medical Research Council
01-06-2015 - 16-06-2019
bullet iconThe role and mechanism of action of p110delta P13K signalling in gastrointedtinal immunity and inflammation
Ezra Aksoy
£27,227 EU European Commission - Other
01-06-2015 - 14-12-2018