Dr Ezra Aksoy
PhD, MSc, BSc, FHEALecturer
The William Harvey Research Institute
Queen Mary University of London
Queen Mary University of London
Research
intestinal immunity, intestinal repair and regeneration, host-microbiome interactions, nutrient sensing pathways, phosphoinositol 3-kinase biology, inflammasome
Interests
Our group is seeking cell signalling targets as biomarkers in immune and epithelial cells in the intestine that impact immune inflammation and regeneration processes. We use in vitro and ex vivo models to test and identify new drug targets associated with process driven inflammation and immune responses.Publications
2021
Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS, Gonzalez-Nuñez M, Austin-Williams SN, Cooper D, Vázquez-Martínez L, Fu T, De Rossi G, Golding M, Voisin M-B, Boulanger CM, Kubota Y, Muller WA, Tooze SA, Nightingale TD, Collinson L, Perretti M, Aksoy E and Nourshargh S (2021). Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation. Elsevier Immunity vol. 54, (9) 1989-2004.e9.
Thibault B, Ramos‐Delgado F, Pons‐Tostivint E, Therville N, Cintas C, Arcucci S, Cassant‐Sourdy S, Reyes‐Castellanos G, Tosolini M, Villard AV, Cayron C, Baer R, Bertrand‐Michel J, Pagan D, Ferreira Da Mota D, Yan H, Falcomatà C, Muscari F, Bournet B, Delord J, Aksoy E, Carrier A, Cordelier P, Saur D, Basset C and Guillermet‐Guibert J (2021). Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component. Springer Nature EMBO Molecular Medicine vol. 13, (7)
2020
Wood TE, Aksoy E and Hachani A (2020). From Welfare to Warfare: The Arbitration of Host-Microbiota Interplay by the Type VI Secretion System. Frontiers Frontiers in Cellular and Infection Microbiology vol. 10,
Ferguson MS, Chard Dunmall LS, Gangeswaran R, Marelli G, Tysome JR, Burns E, Whitehead MA, Aksoy E, Alusi G, Hiley C, Ahmed J, Vanhaesebroeck B, Lemoine NR and Wang Y (2020). Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus. Elsevier (Cell Press) Molecular Therapy vol. 28, (5) 1263-1275.
2019
Aksoy E (2019). TLRs toll for Tregs. Oxford University Press (OUP) Journal of Leukocyte Biology vol. 106, (6) 1193-1195.
Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L, Molendi-Coste O, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte J-S, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K, Carmeliet P and Marot G (2019). Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Elsevier Cell vol. 177, (5) 1201-1216.e19.
Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L, Molendi-Coste O, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte JS, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K, Carmeliet P and Marot G (2019). Erratum: Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR (Cell (2019) 177(5) (1201–1216.e19), (S0092867419302806), (10.1016/j.cell.2019.03.018)). Cell vol. 178, (1) 263-263.
Sun D, Stopka-Farooqui U, Barry S, Aksoy E, Parsonage G, Vossenkämper A, Capasso M, Wan X, Norris S, Marshall JL, Clear A, Gribben J, MacDonald TT, Buckley CD, Korbonits M and Haworth O (2019). Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation. Elsevier Cell Reports vol. 27, (5) 1461-1471.e4.
2018
Aksoy E, Saveanu L and Manoury B (2018). The Isoform Selective Roles of PI3Ks in Dendritic Cell Biology and Function. Frontiers Media SA Frontiers in Immunology vol. 9,
2015
Simeoli R, Mattace Raso G, Lama A, Pirozzi C, Santoro A, Di Guida F, Sanges M, Aksoy E, Calignano A, D'Arienzo A and Meli R (2015). Preventive and Therapeutic Effects of Lactobacillus Paracasei B21060–Based Synbiotic Treatment on Gut Inflammation and Barrier Integrity in Colitic Mice 1–3. Elsevier Journal of Nutrition vol. 145, (6) 1202-1210.
2014
Bontems P, Aksoy E, Burette A, Segers V, Deprez C, Mascart F and Cadranel S (2014). NF‐κB Activation and Severity of Gastritis in Helicobacter pylori‐Infected Children and Adults. Wiley Helicobacter vol. 19, (3) 157-167.
2013
Aksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno-Martin I, Nock G, Filloux A, Beyaert R, Flamand V and Vanhaesebroeck B (2013). Erratum: Corrigendum: The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Springer Nature Nature Immunology vol. 14, (8) 877-877.
2012
Aksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno IM, Nock G, Filloux A, Beyaert R, Flamand V and Vanhaesebroeck B (2012). The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Springer Nature Nature Immunology vol. 13, (11) 1045-1054.
AKSOY-POISTER E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno IM, Nock G, Filloux A, Beyaert R, Flamand V and Vanhaesebroeck B (2012). The p110´ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Nat Immunol. vol. 13, (11) 1045-1054.
2011
Johnson J, Molle C, Aksoy E, Goldman M, Goriely S and Willems F (2011). A conventional protein kinase C inhibitor targeting IRF-3-dependent genes differentially regulates IL-12 family members. Elsevier Molecular Immunology vol. 48, (12-13) 1484-1493.
2010
Langlet C, Springael C, Johnson J, Thomas S, Flamand V, Leitges M, Goldman M, Aksoy E and Willems F (2010). PKC‐α controls MYD88‐dependent TLR/IL‐1R signaling and cytokine production in mouse and human dendritic cells. Wiley European Journal of Immunology vol. 40, (2) 505-515.
2008
Goriely S, Aksoy E, De Wit D, Goldman M and Willems F (2008). Toll-like Receptor Responses in Neonatal Dendritic Cells. Hematology, Immunology and Infectious Disease: Neonatology Questions and Controversies
2007
Johnson J, Albarani V, Nguyen M, Goldman M, Willems F and Aksoy E (2007). Protein Kinase Cα Is Involved in Interferon Regulatory Factor 3 Activation and Type I Interferon-β Synthesis*. Elsevier Journal of Biological Chemistry vol. 282, (20) 15022-15032.
Moore F, Buonocore S, Aksoy E, Ouled-Haddou N, Goriely S, Lazarova E, Paulart F, Heirman C, Vaeremans E, Thielemans K, Goldman M and Flamand V (2007). An Alternative Pathway of NF-κB Activation Results in Maturation and T Cell Priming Activity of Dendritic Cells Overexpressing a Mutated IκBα. The American Association of Immunologists The Journal of Immunology vol. 178, (3) 1301-1311.
2006
Aksoy E, Albarani V, Nguyen M, Laes J-F, Ruelle J-L, De Wit D, Willems F, Goldman M and Goriely S (2006). Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells. American Society of Hematology Blood vol. 109, (7) 2887-2893.
2005
Aksoy E, Berghe WV, Detienne S, Amraoui Z, Fitzgerald KA, Haegeman G, Goldman M and Willems F (2005). Inhibition of phosphoinositide 3‐kinase enhances TRIF‐dependent NF‐κB activation and IFN‐β synthesis downstream of Toll‐like receptor 3 and 4. Wiley European Journal of Immunology vol. 35, (7) 2200-2209.
2004
Aksoy E, Zouain CS, Vanhoutte F, Fontaine J, Pavelka N, Thieblemont N, Willems F, Ricciardi-Castagnoli P, Goldman M, Capron M, Ryffel B and Trottein F (2004). Double-stranded RNAs from the Helminth Parasite Schistosoma Activate TLR3 in Dendritic Cells*. Elsevier Journal of Biological Chemistry vol. 280, (1) 277-283.
Vosters O, Beuneu C, Nagy N, Movahedi B, Aksoy E, Salmon I, Pipeleers D, Goldman M and Verhasselt V (2004). CD40 expression on human pancreatic duct cells: role in nuclear factor-kappa B activation and production of pro-inflammatory cytokines. Springer Nature Diabetologia vol. 47, (4) 660-668.
Aksoy E, Goldman M and Willems F (2004). Protein kinase C epsilon: a new target to control inflammation and immune-mediated disorders. Elsevier The International Journal of Biochemistry & Cell Biology vol. 36, (2) 183-188.
2002
Aksoy E, Amraoui Z, Goriely S, Goldman M and Willems F (2002). Critical role of protein kinase C ϵ for lipopolysaccharide‐induced IL‐12 synthesis in monocyte‐derived dendritic cells. Wiley European Journal of Immunology vol. 32, (11) 3040-3049.
Tonon S, Goriely S, Aksoy E, Pradier O, Del Giudice G, Trannoy E, Willems F, Goldman M and De Wit D (2002). Bordetella pertussis toxin induces the release of inflammatory cytokines and dendritic cell activation in whole blood: impaired responses in human newborns. Wiley European Journal of Immunology vol. 32, (11) 3118-3125.
Ismaili J, Rennesson J, Aksoy E, Vekemans J, Vincart B, Amraoui Z, Van Laethem F, Goldman M and Dubois PM (2002). Monophosphoryl Lipid A Activates Both Human Dendritic Cells and T Cells. The American Association of Immunologists The Journal of Immunology vol. 168, (2) 926-932.
2001
Vanderheyde N, Aksoy E, Amraoui Z, Vandenabeele P, Goldman M and Willems F (2001). Tumoricidal Activity of Monocyte-Derived Dendritic Cells: Evidence for a Caspase-8-Dependent, Fas-Associated Death Domain-Independent Mechanism. The American Association of Immunologists The Journal of Immunology vol. 167, (7) 3565-3569.
2000
Willems F, Amraoui Z, Vanderheyde N, Verhasselt V, Aksoy E, Scaffidi C, Peter ME, Krammer PH and Goldman M (2000). Expression of c-FLIP(L) and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide. American Society of Hematology Blood vol. 95, (11) 3478-3482.
Grants
Uncovering selective role of PI3K signalling in antigen cross presentation in the phagosome
Esra Aksoy-Poister
£11,630 Royal Society (01-04-2022 - 31-03-2025)
Esra Aksoy-Poister
£11,630 Royal Society (01-04-2022 - 31-03-2025)