Dr Emilie Marhuenda
PDRA
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
Cardiomyocyte, Mechanobiology, Heart Disease, Intercalated Discs, Cell-cell signaling, Mechanosensing
Publications
Publications of specific relevance to Predictive in vitro Models2024
Tunable electrospun scaffolds of polyacrylonitrile loaded with carbon nanotubes: from synthesis to biological applicationsFromager B, Cambedouzou J, Marhuenda E, Iskratsch T, Pinault M, Bakalara N and Cornu D
Chembiochem, Wiley vol. 25 (7)
12-03-2024
Vascularised cardiac spheroids-on-a-chip for testing the toxicity of therapeuticsDi Cio S, Marhuenda E, Haddrick M and Gautrot JE
Scientific Reports, Springer Nature vol. 14 (1)
09-02-2024
Sox9 Accelerates Vascular Aging by Regulating Extracellular Matrix Composition and StiffnessFaleeva M, Ahmad S, Theofilatos K, Lynham S, Watson G, Whitehead M, Marhuenda E, Iskratsch T, Cox S and Shanahan CM
Circulation Research, Wolters Kluwer vol. 134 (3), 307-324.
05-01-2024
2023
Hypertensive pressure mechanosensing alone triggers lipid droplet accumulation and
transdifferentiation of vascular smooth muscle cells to foam cellsIskratsch T, Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q, Graham D and Shanahan C
Advanced Science, Wiley Open Access
25-12-2023
Recent Advances in Electrospun Fibers for Biological ApplicationsFromager B, Marhuenda E, Louis B, Bakalara N, Cambedouzou J and Cornu D
Macromol—a Journal of Macromolecular Research, Mdpi vol. 3 (3), 569-613.
16-08-2023
Lem2 is essential for cardiac development by maintaining nuclear integrityRoss JA, Arcos-Villacis N, Battey E, Boogerd C, Orellana CA, Marhuenda E, Swiatlowska P, Hodzic D, Prin F, Mohun T, Catibog N, Tapia O, Gerace L, Iskratsch T, Shah AM and Stroud MJ
Cardiovascular Research, Oxford University Press (Oup) vol. 119 (11), 2074-2088.
17-04-2023
2022
Photoelectrochemical imaging of single cardiomyocytes and monitoring of their action potentials through contact force manipulation of organoidsJacques R, Zhou B, Marhuenda E, Gorecki J, Das A, Iskratsch T and Krause S
Biosensors and Bioelectronics, Elsevier
21-12-2022
Crosstalk between cell-matrix and cell-cell signaling in cardiomyocyte mechanosensingMarhuenda E, Iskratsch T and Xanthis I
Journal of Molecular and Cellular Cardiology, Elsevier vol. 173
01-12-2022
Mechanoregulation of vascular smooth muscle cells phenotype in atherosclerosisSwiatlowska P, Sit B, Feng Z, Marhuenda E, Zhou X, Xiao Q, Shanahan C, Yu C-H and Iskratsch T
Journal of Molecular and Cellular Cardiology, Elsevier vol. 173, 41-42.
01-12-2022
The cardiomyocyte mechanical code – Mechanical imprinting of talin interactions regulate cardiomyocyte mechanosensing and functionMarhuenda E, Pandey P, Xanthis I, O'Neill C and Iskratsch T
Journal of Molecular and Cellular Cardiology, Elsevier vol. 173
01-12-2022
Regulation of Cardiomyocyte Adhesion and
Mechanosignalling Through Distinct Nanoscale Behaviour of
Integrin Ligands Mimicking Healthy or Fibrotic ECMIskratsch T, Hawkes W, Marhuenda E, Reynolds P, O'Neill C, PANDEY P, Wilson D, FREELEY M, HUANG D, Junquiang H, Gondarenko S, Hone J, Gadegaard N and Palma M
Philosophical Transactions of The Royal Society B: Biological Sciences, The Royal Society
21-11-2022
Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switchingSwiatlowska P, Sit BHM, Zhen F, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones G, Yu C-H and Iskratsch T
Science Advances, American Association For The Advancement of Science
15-04-2022
2021
Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensingMarhuenda E, Fabre C, Zhang C, Martin-Fernandez M, Iskratsch T, Saleh A, Bauchet L, Cambedouzou J, Hugnot JP, Duffau H, Dennis JW, Cornu D and Bakalara N
Journal of Experimental and Clinical Cancer Research vol. 40 (1)
24-04-2021
Targeting Several Biologically Reported Targets of Glioblastoma Multiforme by Assaying 2D and 3D Cultured CellsSixto-López Y, Marhuenda E, García-Vazquez JB, Fragoso-Vazquez MJ, Rosales-Hernández MC, Zacarías-Lara O, Méndez-Luna D, Gómez-Vidal JA, Cornu D, Norbert B and Correa-Basurto J
Cellular and Molecular Neurobiology, Springer Nature vol. 42 (6), 1909-1920.
19-03-2021
2020
Matrix stiffness and blood pressure together regulate vascular smooth muscle cell phenotype switchingSwiatlowska P, Sit B, Feng Z, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones GE, Yu C-H and Iskratsch T
, Cold Spring Harbor Laboratory
28-12-2020
Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensingMarhuenda E, Fabre C, Zhang C, Martin-Fernandez M, Iskratsch T, Saleh A, Bauchet L, Cambedouzou J, Hugnot J-P, Duffau H, Dennis JW, Cornu D and Bakalara N
, Cold Spring Harbor Laboratory
26-09-2020
2019
A novel 3D nanofibre scaffold conserves the plasticity of glioblastoma stem cell invasion by regulating galectin-3 and integrin-β1 expressionSaleh A, Marhuenda E, Fabre C, Hassani Z, Weille JD, Boukhaddaoui H, Guelfi S, Maldonado IL, Hugnot J-P, Duffau H, Bauchet L, Cornu D and Bakalara N
Scientific Reports, Springer Nature vol. 9 (1)
10-10-2019