Dr Egle Solito
Reader in Immunobiology
The William Harvey Research Institute
Queen Mary University of London
Queen Mary University of London
Research
Blood-Brain Barrier (BBB), Immunobiology, Inflammation, Cerebrovascular Dementia, Ageing, Metabolism
Interests
Development of human in vitro model of Blood-Brain Barrier (BBB) for the study of drug delivery and ex vivo system biology of the CNS and associated pathologiesPublications
Publications of specific relevance to Predictive in vitro Models
2024
Stolp HB and Solito E (2024). Developmental priming of early cerebrovascular ageing: Implications across a lifetime. Wiley International Journal of Geriatric Psychiatry vol. 39, (4)
2023
Fu H, Vuononvirta J, Fanti S, Bonacina F, D’Amati A, Wang G, Poobalasingam T, Fankhaenel M, Lucchesi D, Coleby R, Tarussio D, Thorens B, Hearnden RJ, Longhi M, Grevitt P, Madeeha S, Egle S, Godinho S, Bombardieri M, Smith D, Cooper D, Asif I, Rathmell JC, Schaefer S, Morales V, Bianchi K, Norata GD and Marelli-Berg F (2023). The Glucose Transporter 2 regulates CD8+ T cell function via environment sensing., Editors: Figliuolo ML. Nature Research Nature Metabolism
Cortese P, Amato F, Davino A, De Franchis R, Esposito S, Zollo I, Di Domenico M, Solito E, Zarrilli F, Gentile L, Cernera G and Castaldo G (2023). The Immune Response to SARS-CoV-2 Vaccine in a Cohort of Family Pediatricians from Southern Italy. MDPI Cells vol. 12, (11)
De Vitis C, Battaglia AM, Pallocca M, Santamaria G, Mimmi MC, Sacco A, De Nicola F, Gaspari M, Salvati V, Ascenzi F, Bruschini S, Esposito A, Ricci G, Sperandio E, Massacci A, Prestagiacomo LE, Vecchione A, Ricci A, Sciacchitano S, Salerno G, French D, Aversa I, Cereda C, Fanciulli M, Chiaradonna F, Solito E, Cuda G, Costanzo F, Ciliberto G and Mancini R (2023). ALDOC- and ENO2- driven glucose metabolism sustains 3D tumor spheroids growth regardless of nutrient environmental conditions: a multi-omics analysis. Springer Nature Journal of Experimental & Clinical Cancer Research vol. 42, (1)
2022
Wickstead ES, Solito E and Mcarthur S (2022). Promiscuous Receptors and Neuroinflammation: The Formyl Peptide Class. MDPI Life vol. 12, (12)
Fanti S, Stephenson E, Rocha-Vieira E, Protonotarios A, Kanoni S, Shahaj E, Longhi MP, Vyas VS, Dyer C, Pontarini E, Asimaki A, Bueno-Beti C, De Gaspari M, Rizzo S, Basso C, Bombardieri M, Coe D, Wang G, Harding D, Gallagher I, Solito E, Elliott P, Heymans S, Sikking M, Savvatis K, Mohiddin SA and Marelli-Berg FM (2022). Circulating c-Met–Expressing Memory T Cells Define Cardiac Autoimmunity. Wolters Kluwer Circulation vol. 146, (25) 1930-1945.
Robbins JP and Solito E (2022). Does Neuroinflammation Underlie the Cognitive Changes Observed With Dietary Interventions? Frontiers Frontiers in Neuroscience vol. 16,
2021
Sheikh MH, Errede M, d'Amati A, Khan NQ, Fanti S, Loiola RA, McArthur S, Purvis GSD, O'Riordan CE, Ferorelli D, Dell'Erba A, Kieswich J, Reutelingsperger C, Maiorano E, Yaqoob M, Thiemermann C, Baragetti A, Catapano AL, Norata GD, Marelli‐Berg F, Virgintino D and Solito E (2021). Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood‐brain barrier: Therapeutic avenues. Wiley The FASEB Journal vol. 36, (1)
Hoyles L, Pontifex M, Rodriguez-Ramiro I, Anis-Alavi MA, Jelane KS, Snelling T, Solito E, Fonseca S, Carvalho AL, Carding SR, Muller M, Glen RC, Vauzour D and Mcarthur S (2021). Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide. BioMed Central Microbiome
Chee SEJ and Solito E (2021). The Impact of Ageing on the CNS Immune Response in Alzheimer’s Disease. Frontiers Frontiers in Immunology vol. 12,
Mohammad S, Zoubi SA, Collotta D, Krieg N, Wissuwa B, Alves GF, Purvis GSD, Norata GD, Baragetti A, Catapano AL, Solito E, Zechendorf E, Schürholz T, Correa-Vargas W, Brandenburg K, Coldewey SM, Collino M, Yaqoob MM, Martin L and Thiemermann C (2021). A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice. Frontiers in Immunology vol. 12, 701275-701275.
Reis M, Watts H, Mota B, Yanez-lopez M, Donat C, Baxan N, Pickering J, Chaw T, Annika S, Brinda G, Aleksynas R, Habelleiras-Hervas L, Iqbal S, Romero-Molina C, Hernandez-Mir G, d'Amati A, Reutelingsperger C, Goldfinger M, Gentleman S, Leuven F, Sastre M and Solito E (2021). Annexin-A1 restores cerebrovascular integrity concomitant with reduced amyloid-β and tau pathology. Oxford University Press (OUP) Brain: a journal of neurology
2020
Solito E, Marelli-Berg F, Fanti S, Cheung K, Mauro C, Wang G, Nair A, Fu H, Angeletti S, Spoto S, Fogolari M, Romano F, Aksentijevic D, Liu W, Li B, Cheng L, YANG LW, Juho V, Thanushiyan P, Smith D and Ciccozzi M (2020). Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming. Nature Research (part of Springer Nature) Nature Communications vol. 11,
Majkowska A, Redondo-Gómez C, Rice A, Gonzalez M, Inostroza-Brito KE, Collin EC, Rodriguez-Cabello JC, Del Rio Hernandez AE, Solito E and Mata A (2020). Interfacial Self-Assembly to Spatially Organize Graphene Oxide Into Hierarchical and Bioactive Structures. Frontiers Frontiers in Materials vol. 7,
Sheikh MH, Henson S, Loiola RA, Mercurio S, Colamatteo A, Maniscalco GT, De Rosa V, Mcarthur S and Solito E (2020). Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier. BioMed Central Journal of Neuroinflammation
2019
Callender L, Carroll E, BOBER E, Akbar A, Solito E and Henson S (2019). Mitochondrial mass governs the extent of human T cell senescence. John Wiley & Sons Ltd Aging Cell vol. 19, (2)
Solito E, Montague-Cardoso K, Pitcher T, Chisolm K, Salera G, Lindstrom E, Hewitt E and Malcangio M (2019). Changes in vascular permeability in the spinal cord contribute to chemotherapy- induced neuropathic pain. Elsevier Brain Behaviour and Immunity
Solito E, Zub E, Canet G, Garbelli R, Blaquiere M, Rossini L, Pastori C, Sheikh M, Reutelingsperger C, Klement W, de Bock F, Audinat E, Givalois L and Marchi N (2019). The GR-ANXA1 pathway is a pathological player and a candidate target in epilepsy., Editors: Weksler B. Federation of American Society of Experimental Biology The FASEB Journal
Solito E, Colamatteo A, Maggioli E, Azevedo Loiola R, Sheikh M, Cali G, Bruzzese D, Maniscalco T, Centonze D, Buttari F, Lanzillo R, Perna F, Zuccarelli B, Mottola M, Cassano S, Galgani M and De Rosa V (2019). Reduced Annexin A1 expression associates with disease severity and inflammation in multiple sclerosis patients. American Association of Immunologists Journal of Immunology
da Rocha GHO, Loiola RA, Pantaleão LDN, Reutelingsperger C, Solito E and Farsky SHP (2019). Control of expression and activity of peroxisome proliferated-activated receptor γ by Annexin A1 on microglia during efferocytosis. Wiley Cell Biochemistry and Function
Loiola RA, Wickstead ES, Solito E and Mcarthur S (2019). Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance Through the Actions of Annexin A1. Frontiers Media Frontiers in Endocrinology
SOLITO EGLE, PURVIS G and THIEMERMANN C (2019). Annexin-A1: therapeutic potential in microvascular disease. Frontiers Media Frontiers in Immunology
Purvis GSD, Collino M, Loiola RA, Baragetti A, Chiazza F, Brovelli M, Sheikh MH, Collotta D, Cento A, Mastrocola R, Aragno M, Cutrin JC, Reutelingsperger C, Grigore L, Catapano AL, Yaqoob MM, Norata GD, Solito E and Thiemermann C (2019). Identification of AnnexinA1 as an Endogenous Regulator of RhoA, and Its Role in the Pathophysiology and Experimental Therapy of Type-2 Diabetes. Frontiers Frontiers in Immunology vol. 10,
2018
SOLITO E (2018). Connections of Annexin A1 and Translocator Protein-18 KDa on Toll Like Receptor Stimulated BV-2 Cells. Exp Cell Res.
SOLITO E and SHEIKH M (2018). Annexin A1: Uncovering the Many Talents of an Old Protein. MDPI AG International Journal of Molecular Sciences vol. 19,
S. D. Purvis G and Solito E (2018). Is AnnexinA1 The Miracle Drug For Diabetes? Science Trends Science Trends
2017
Purvis GSD, Chiazza F, Chen J, Loiola RA, Martin L, Fountoulakis N, Gnudi L, Collino M, Thiemermann C and Solito E (2017). Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes. Springer Verlag Diabetologia
Lima KM, Vago JP, Caux TR, Negreiros-Lima GL, Sugimoto MA, Tavares LP, Arribada RG, Carmo AAF, Galvão I, Costa BRC, Soriani FM, Pinho V, Solito E, Perretti M, Teixeira MM and Sousa LP (2017). The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1. Elsevier Journal of Biological Chemistry vol. 292, (33) 13758-13773.
2016
McArthur S, Loiola RA, Maggioli E, Errede M, Virgintino D and SOLITO E (2016). The restorative role of annexin A1 at the blood–brain barrier. BioMed Central Fluids and Barriers of the CNS vol. 13, (17)
SOLITO E, Loiola R, Ries M, Shah U, Gentleamn S and Sastre M (2016). The anti-inflammatory Annexin A1 induces
the clearance and degradation of the
amyloid-β peptide. BioMed Central Journal of Neuroinflammation vol. 13,
Sinniah A, Yazid S, Perretti M, Solito E and Flower RJ (2016). The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil. Elsevier International Immunopharmacology vol. 32, 87-95.
2015
Maggioli E, McArthur S, Mauro C, Kieswich J, Kusters DHM, Reutelingsperger CPM, Yaqoob M and Solito E (2015). Estrogen protects the blood–brain barrier from inflammation-induced disruption and increased lymphocyte trafficking. Elsevier Brain Behavior and Immunity vol. 51, 212-222.
Yazid S, Gardner PJ, Carvalho L, Chu CJ, Flower RJ, Solito E, Lee RWJ, Ali RR and Dick AD (2015). Annexin-A1 restricts Th17 cells and attenuates the severity of autoimmune disease. Elsevier Journal of Autoimmunity vol. 58, 1-11.
Mauro C, De Rosa V, Marelli-Berg F and Solito E (2015). Metabolic Syndrome and the Immunological Affair with the Blood–Brain Barrier. Frontiers Frontiers in Immunology vol. 5,
2014
Queiroz CJDS, Nakata CMDAG, Solito E and Damazo AS (2014). Relationship between HPV and the biomarkers annexin A1 and p53 in oropharyngeal cancer. Infect Agent Cancer vol. 9,
dos Santos Queiroz CJ, de Amorim Gomes Nakata CM, Solito E and Damazo AS (2014). Relationship between HPV and biomarkers annexin A1 and P53 in oropharyngeal cancer. Elsevier Pathology vol. 46,
2013
Girol AP, Mimura KKO, Drewes CC, Bolonheis SM, Solito E, Farsky SHP, Gil CD and Oliani SM (2013). Anti-inflammatory mechanisms of the annexin A1 protein and its mimetic peptide Ac2-26 in models of ocular inflammation in vivo and in vitro. J Immunol vol. 190, (11) 5689-5701.
Cristante E, McArthur S, Mauro C, Maggioli E, Romero IA, Wylezinska-Arridge M, Couraud PO, Lopez-Tremoleda J, Christian HC, Weksler BB, Malaspina A and Solito E (2013). Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications. Proc Natl Acad Sci U S A vol. 110, (3) 832-841.
Yazid S, Sinniah A, Solito E, Calder V and Flower RJ (2013). Anti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1. PLoS One vol. 8, (3)
2012
Mehet DK, Philip J, Solito E, Buckingham JC and John CD (2012). Evidence from in vitro and in vivo studies showing that nuclear factor-κB within the pituitary folliculostellate cells and corticotrophs regulates adrenocorticotrophic hormone secretion in experimental endotoxaemia. J Neuroendocrinol vol. 24, (6) 862-873.
Solito E and Sastre M (2012). Microglia function in Alzheimer's disease. Front Pharmacol vol. 3,
2010
McArthur S, Cristante E, Paterno M, Christian H, Roncaroli F, Gillies GE and Solito E (2010). Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia. J Immunol vol. 185, (10) 6317-6328.
Yazid S, Leoni G, Getting SJ, Cooper D, Solito E, Perretti M and Flower RJ (2010). Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization. Arterioscler Thromb Vasc Biol vol. 30, (9) 1718-1724.
Yazid S, Ayoub SS, Solito E, McArthur S, Vo P, Dufton N and Flower RJ (2010). Anti-allergic drugs and the Annexin-A1 system. Pharmacol Rep vol. 62, (3) 511-517.
2009
McArthur S, Yazid S, Christian H, Sirha R, Flower R, Buckingham J and Solito E (2009). Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization. FASEB J vol. 23, (11) 4000-4010.
Yazid S, Solito E, Christian H, McArthur S, Goulding N and Flower R (2009). Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1. Biochem Pharmacol vol. 77, (12) 1814-1826.
2008
Yazid S, Solito E, Christian H, Goulding N and Flower R (2008). Further studies on the rapid glucocorticoid effects in the U937 monocytic cell line and its potentiation by cromoglycate-like drugs. FUND CLIN PHARMACOL vol. 22, 47-47.
McArthur S, Prasongchean W, Gillies G and Solito E (2008). A critical role for the anti-inflammatory protein annexin A1 in microglial phagocytosis. FUND CLIN PHARMACOL vol. 22, 23-23.
Damazo AS, Flower RJ, Solito E and Oliani SM (2008). Annexin-A1 gene expression during liver development and post-translation modification after experimental endotoxemia. INFLAMM RES vol. 57, (3) 97-103.
Hu NJ, Bradshaw J, Lauter H, Buckingham J, Solito E and Hofmann A (2008). Membrane-induced folding and structure of membrane-bound annexin A1 N-terminal peptides: Implications for annexin-induced membrane aggregation. BIOPHYS J vol. 94, (5) 1773-1781.
Solito E, McArthur S, Christian H, Gavins F, Buckingham JC and Gillies GE (2008). Annexin A1 in the brain--undiscovered roles? Trends Pharmacol Sci vol. 29, (3) 135-142.
2007
John CD, Sahni V, Mehet D, Morris JF, Christian HC, Perretti M, Flower RJ, Solito E and Buckingham JC (2007). Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin A1, lipoxins, and bacterial peptides. FASEB J vol. 21, (4) 1037-1046.
2006
Warne JP, John CD, Christian HC, Morris JF, Flower RJ, Sugden D, Solito E, Gillies GE and Buckingham JC (2006). Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue. AM J PHYSIOL-ENDOC M vol. 291, (6) E1264-E1273.
Kamal AM, Hayhoe RPG, Paramasivam A, Cooper D, Flower RJ, Solito E and Perretti M (2006). Antiflammin-2 activates the human formyl-peptide receptor like 1. ScientificWorldJournal vol. 6, 1375-1384.
Buckingham J, John C, Solito E, Flower R, Christian H and Morris J (2006). Annexin 1: a mediator of glucocorticoid action at the neuroendocrine-immune interface. ACTA PHARMACOL SIN vol. 27, 1-1.
FLOWER RJ, Buckingham JC, Tierney T, Festa M, Christian HC, Solito E and Mulla A (2006). Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface. Faseb J vol. 20, (9) 1498-1500.
Solito E, Christian HC, Festa M, Mulla A, Tierney T, Flower RJ and Buckingham JC (2006). Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface. FASEB J vol. 20, (9) 1498-1500.
Petrella A, Festa M, Ercolino SF, Zerilli M, Stassi G, Solito E and Parente L (2006). Down-regulation of annexin-1 expression in thyroid cancers is associated with tumour aggressiveness. ACTA PHARMACOL SIN vol. 27, 65-65.
Petrella A, Festa M, Ercolino SF, Zerilli M, Stassi G, Solito E and Parente L (2006). Annexin-1 downregulation in thyroid cancer correlates to the degree of tumor differentiation. Cancer Biol Ther vol. 5, (6) 643-647.
Rodrigues-Lisoni FC, Mehet DK, Peitl P, John CD, da Silva WA, Tajara E, Buckingham JC and Solito E (2006). In vitro and in vivo studies on CCR10 regulation by Annexin A1 (vol 580, pg 1431, 2006). FEBS LETT vol. 580, (7) 1908-1908.
Hayhoe RPG, Kamal AM, Solito E, Flower RJ, Cooper D and Perretti M (2006). Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement. BLOOD vol. 107, (5) 2123-2130.
Rodrigues-Lisoni FC, Mehet DK, Peitl P, John CD, da Silva Júnior WA, Tajara E, Buckingham JC and Solito E (2006). In vitro and in vivo studies on CCR10 regulation by Annexin A1. FEBS Lett vol. 580, (5) 1431-1438.
2005
Petrella A, Festa M, Ercolino SF, Zerilli M, Stassi G, Solito E and Parente L (2005). Induction of annexin-1 during TRAIL-induced apoptosis in thyroid carcinoma cells. Cell Death Differ vol. 12, (10) 1358-1360.
Rodrigues-Lisoni FC, Oliani S, Buckingham J, Solito E and Tajara EH (2005). Annexin A1: From gene organization to physiology. Annexins vol. 2, (2)
Mulla A, Leroux C, Solito E and Buckingham JC (2005). Correlation between the antiinflammatory protein annexin 1 (lipocortin 1) and serum cortisol in subjects with normal and dysregulated adrenal function. J Clin Endocrinol Metab vol. 90, (1) 557-562.
2004
Perretti M and Solito E (2004). Annexin 1 and neutrophil apoptosis. BIOCHEMICAL SOCIETY TRANSACTIONS vol. 32, 507-510.
John CD, Christian HC, Morris JF, Flower RJ, Solito E and Buckingham JC (2004). Annexin 1 and the regulation of endocrine function. TRENDS ENDOCRIN MET vol. 15, (3) 103-109.
Parente L and Solito E (2004). Annexin 1: more than an anti-phospholipase protein. Inflamm Res vol. 53, (4) 125-132.
Mulla A, Christian HC, Solito E, Mendoza N, Morris JF and Buckingham JC (2004). Expression, subcellular localization and phosphorylation status of annexins 1 and 5 in human pituitary adenomas and a growth hormone-secreting carcinoma. Clin Endocrinol (Oxf) vol. 60, (1) 107-119.
2003
Tierney T, Christian HC, Morris JF, Solito E and Buckingham JC (2003). Evidence from studies on co-cultures of TtT/GF and AtT20 cells that Annexin 1 acts as a paracrine or juxtacrine mediator of the early inhibitory effects of glucocorticoids on ACTH release. J Neuroendocrinol vol. 15, (12) 1134-1143.
John CD, Christian HC, Morris JF, Flower RJ, Solito E and Buckingham JC (2003). Kinase-dependent regulation of the secretion of thyrotrophin and luteinizing hormone by glucocorticoids and annexin 1 peptides. J Neuroendocrinol vol. 15, (10) 946-957.
de Coupade C, Solito E and Levine JD (2003). Dexamethasone enhances interaction of endogenous annexin 1 with L-selectin and triggers shedding of L-selectin in the monocytic cell line U-937. Br J Pharmacol vol. 140, (1) 133-145.
Buckingham JC, Solito E, John C, Tierney T, Taylor A, Flower R, Christian H and Morris J (2003). Annexin 1: a paracrine/juxtacrine mediator of glucorticoid action in the neuroendocrine system. Cell Biochem Funct vol. 21, (3) 217-221.
Solito E, Kamal A, Russo-Marie F, Buckingham JC, Marullo S and Perretti M (2003). A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils. FASEB J vol. 17, (9) 1544-+.
Croxtall JD, Gilroy DW, Solito E, Choudhury Q, Ward BJ, Buckingham JC and Flower RJ (2003). Attenuation of glucocorticoid functions in an Anx-A1-/- cell line. Biochem J vol. 371, (Pt 3) 927-935.
Solito E, Mulla A, Morris JF, Christian HC, Flower RJ and Buckingham JC (2003). Dexamethasone induces rapid serine-phosphorylation and membrane translocation of annexin 1 in a human folliculostellate cell line via a novel nongenomic mechanism involving the glucocorticoid receptor, protein kinase c, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase. ENDOCRINOLOGY vol. 144, (4) 1164-1174.
FLOWER RJ, John C, Solito E, Morris J, Tierney T, Taylor A, Christian H and Buckingham JC (2003). Annexin 1: a paracrine/juxtacrine mediator of glucorticoid action in the neuroendocrine system. Cell Biochemistry and Function. vol. 21, (3) 217-221.
FLOWER RJ, Morris JF, Christian HC, Buckingham JC, Solito E and John CD (2003). Kinase-Dependent Regulation of the Secretion of Thyrotrophin and Luteinizing Hormone By Glucocorticoids and Annexin 1 Peptides. J Neuroendocrinol. vol. 15, (10) 946-957.
2002
Perretti M, Chiang N, La M, Fierro IM, Marullo S, Getting SJ, Solito E and Serhan CN (2002). Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nat Med vol. 8, (11) 1296-1302.
Perretti M, Ingegnoli F, Wheller SK, Blades MC, Solito E and Pitzalis C (2002). Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model. J Immunol vol. 169, (4) 2085-2092.
Mulla A, Buckingham JC and Solito E (2002). LPS acts via IL-6 and IL-1 to modulate the expression and phosphorylation of annexin 1 in cell lines derived from the putative microglia of the neuroendocrine system. BRIT J PHARMACOL vol. 135,
Solito E, Mulla A and Buckingham JC (2002). Dexamethasone induces serine phosphorylation of annexin 1: Involvement of PKC and PI3-kinase. BRIT J PHARMACOL vol. 135,
Solito E, Mulla A, Flower RJ and Buckingham JC (2002). Lipocortin 1 (Annexin 1). Wiley Encyclopedia of Molecular Medicine Wiley
FLOWER RJ, Buckingham J, Christian H, Solito E, John C, Cover P and Morris J (2002). Annexin 1-dependent actions of glucocorticoids in the anterior pituitary gland: roles of the N-terminal domain and protein kinase C. Endocrinology. vol. 143, (8) 3060-3070.
2001
de Coupade C, Ajuebor MN, Russo-Marie F, Perretti M and Solito E (2001). Cytokine modulation of liver annexin 1 expression during experimental endotoxemia. AM J PATHOL vol. 159, (4) 1435-1443.
Kamal AM, Smith SF, De Silva Wijayasinghe M, Solito E and Corrigan CJ (2001). An annexin 1 (ANXA1)-derived peptide inhibits prototype antigen-driven human T cell Th1 and Th2 responses in vitro. Clin Exp Allergy vol. 31, (7) 1116-1125.
Perretti M, Getting SJ, Solito E, Murphy PM and Gao JL (2001). Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. AM J PATHOL vol. 158, (6) 1969-1973.
John CD, Solito E, Mulla A, Morris JF, Flower RJ and Buckingham JC (2001). Dexamethasone induces serine phosphorylation of annexin 1 in pituitary cells and suppresses ACTH release by a PKC-dependent mechanism. BRIT J PHARMACOL vol. 133, U20-U20.
Solito E, de Coupade C, Canaider S, Goulding NJ and Perretti M (2001). Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase-3 activation. BRIT J PHARMACOL vol. 133, (2) 217-228.
2000
Solito E, Tissot M, Russo-Marie F and Marullo S (2000). Extracellular annexin-1 accelerates apoptosis of human polymorphonuclears neutrophils. MOL BIOL CELL vol. 11, 462A-463A.
D'Amico M, Di Filippo C, La M, Solito E, McLean PG, Flower RJ, Oliani SM and Perretti M (2000). Lipocortin 1 reduces myocardial ischemia-reperfusion injury by affecting local leukocyte recruitment. FASEB J vol. 14, (13) 1867-1869.
Solito E, Romero IA, Marullo S, Russo-Marie F and Weksler BB (2000). Annexin 1 binds to U937 monocytic cells and inhibits their adhesion to microvascular endothelium: involvement of the alpha 4 beta 1 integrin. J Immunol vol. 165, (3) 1573-1581.
Mulla A, Christian H, Morris J, Mendoza N, Solito E and Buckingham J (2000). Expression of annexins 1 and 5 in human pituitary tumours. J PHYSIOL-LONDON vol. 525, 53P-54P.
Solito E, Tissot M, Russo-Marie F and Marullo S (2000). Extracellular Annexin 1 induces apoptosis of human polymorphonuclear neutrophils. FASEB J vol. 14, (8) A1357-A1357.
Le Maire V, Solito E, Russo-Marie F, Hernvann A, Le Marechal H, Ekindjian OG and Aussel C (2000). System A neutral amino acid transporter regulation by interleukin-1beta in human osteoarthritic synovial cells: evidence for involvement of prostaglandin E(2) as a second messenger. J Cell Physiol vol. 183, (1) 65-73.
Canaider S, Solito E, de Coupade C, Flower RJ, Russo-Marie F, Goulding NJ and Perretti M (2000). Increased apoptosis in U937 cells over-expressing lipocortin 1 (annexin I). Life Sci vol. 66, (18) PL265-PL270.
Perretti M, Solito E, La M, Russo-Marie F, Marullo S, D'Amico M and Flower RJ (2000). Annexin 1 activates human neutrophils: A mechanism for its anti-inflammatory in vivo effect. FASEB J vol. 14, (4) A8-A8.
de Coupade C, Gillet R, Bennoun M, Briand P, Russo-Marie F and Solito E (2000). Annexin 1 expression and phosphorylation are upregulated during liver regeneration and transformation in antithrombin III SV40 T large antigen transgenic mice. Hepatology vol. 31, (2) 371-380.
D'Amico M, Di Filippo C, Solito E, Flower RJ and Perretti M (2000). Lipocortin 1 inhibits myocardial infarct by reducing local neutrophil infiltration. BRIT J PHARMACOL vol. 129, U56-U56.
1999
Gidon-Jeangirard C, Solito E, Hofmann A, Russo-Marie F, Freyssinet JM and Martínez MC (1999). Annexin V counteracts apoptosis while inducing Ca(2+) influx in human lymphocytic T cells. Biochem Biophys Res Commun vol. 265, (3) 709-715.
Young KA, Hirst WD, Solito E and Wilkin GP (1999). De novo expression of lipocortin-1 in reactive microglia and astrocytes in kainic acid lesioned rat cerebellum. Glia vol. 26, (4) 333-343.
Canaider S, Solito E, Goulding NJ, Flower RJ and Perretti M (1999). Increased apoptosis in cells overexpressing lipocortin 1. BRIT J PHARMACOL vol. 126, U26-U26.
John CD, Cover PO, Taylor AD, Morris JF, Flower RJ, Solito E and Buckingham JC (1999). Evidence from in vivo and in vitro studies that the inhibitory actions of lipocortin 1 on anterior pituitary function require amino acid residues 13-26. BRIT J PHARMACOL vol. 126, U74-U74.
Raguenes-Nicol C, Russo-Marie F, Domage G, Diab N, Solito E, Dray F, Mace JL and Streichenberger G (1999). Anti-inflammatory mechanism of alminoprofen: action on the phospholipid metabolism pathway. Biochem Pharmacol vol. 57, (4) 433-443.
Raugei G, Degl'Innocenti D, Chiarugi P, Solito E, Modesti A and Ramponi G (1999). Preferential accumulation of muscle type acylphosphatase in the nucleus during differentiation. Biochem Mol Biol Int vol. 47, (1) 127-136.
1998
Lim LH, Solito E, Russo-Marie F, Flower RJ and Perretti M (1998). Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A vol. 95, (24) 14535-14539.
Solito E, Raguenes-Nicol C, de Coupade C, Bisagni-Faure A and Russo-Marie F (1998). U937 cells deprived of endogenous annexin 1 demonstrate an increased PLA2 activity. Br J Pharmacol vol. 124, (8) 1675-1683.
Solito E, de Coupade C, Parente L, Flower RJ and Russo-Marie F (1998). IL-6 stimulates annexin 1 expression and translocation and suggests a new biological role as class II acute phase protein. Cytokine vol. 10, (7) 514-521.
Solito E, de Coupade C, Parente L, Flower RJ and Russo-Marie F (1998). Human annexin 1 is highly expressed during the differentiation of the epithelial cell line A 549: involvement of nuclear factor interleukin 6 in phorbol ester induction of annexin 1. Cell Growth Differ vol. 9, (4) 327-336.
Dubois T, Mira JP, Feliers D, Solito E, Russo-Marie F and Oudinet JP (1998). Annexin V inhibits protein kinase C activity via a mechanism of phospholipid sequestration. Biochem J vol. 330 ( Pt 3), (Pt 3) 1277-1282.
1997
Lim LHK, Getting SJ, Das AM, Solito E, Flower RJ and Perretti M (1997). Inhibition of neutrophil : endothelium interaction in murine post-capillary venules by lipocortin 1. BRIT J PHARMACOL vol. 122, U54-U54.
Voermans PH, Go KG, Horst GJT, Ruiters MHJ, Solito E and Parente L (1997). P-3-325 Steroid-induced expression of annexinin brain. Elsevier Clinical Neurology and Neurosurgery vol. 99, s145-s146.
Voermans PH, Go KG, ter Horst GJ, Ruiters MHJ, Solito E and Parente L (1997). Expression of Annexin and Annexin-mRNA in Rat Brain Under Influence of Steroid Drugs. Brain Edema X Springer Nature
Voermans PH, Go KG, ter Horst GJ, Ruiters MH, Solito E and Parente L (1997). Expression of annexin and annexin-mRNA in rat brain under influence of steroid drugs. Acta Neurochir Suppl vol. 70, 222-224.
1996
Cifone MG, Cironi L, Roncaioli P, Martinotti S, Toniato E, Cilenti L, Botti D, Solito E, Parente L and Santoni A (1996). Phospholipase A(2) activity and calpactin I levels in rat lymphokine-activated killer cells: Correlation with the cytotoxic activity. CELL IMMUNOL vol. 170, (2) 274-282.
Ambrosetti DC, Palla E, Mirtella A, Galeotti C, Solito E, Navarra P, Parente L and Melli M (1996). Synthetic alleles at position 121 define a functional domain of human interleukin-1 beta. Eur J Biochem vol. 238, (2) 308-316.
Voermans PH, Go KG, Horst GJ, Ruiters MH, Solito E and Parente L (1996). Induction of annexin-1 at transcriptional and post-transcriptional level in rat brain by methylprednisolone and the 21-aminosteroid U74389F. Mediators Inflamm vol. 5, (5) 370-378.
1995
Parente L, Ambrosetti D, Palla E, Mirtella A, Galeotti CL, Solito E, Navarra P and Melli M (1995). A new functional binding site for interleukin-1beta? Elsevier Pharmacological Research vol. 31,
1994
Parente L and Solito E (1994). Association between glucocorticosteroids and lipocortin 1. Trends Pharmacol Sci vol. 15, (10)
Solito E, Nuti S and Parente L (1994). Dexamethasone-induced translocation of lipocortin (annexin) 1 to the cell membrane of U-937 cells. Br J Pharmacol vol. 112, (2) 347-348.
Go KG, Zuiderveen F, De Ley L, Ter Haar JG, Parente L, Solito E and Molenaar WM (1994). Effect of steroids on brain lipocortin immunoreactivity. Acta Neurochir Suppl (Wien) vol. 60, 101-103.
Go KG, Ter Haar JG, de Ley L, Zuiderveen F, Parente L, Solito E and Molenaar WM (1994). The effect of steroid treatment on lipocortin immunoreactivity of rat brain. Mediators Inflamm vol. 3, (3) 177-180.
GO KG, ZUIDERVEEN F, DELEY L, TERHAAR JG, PARENTE L, SOLITO E and MOLENAAR WM (1994). EFFECT OF STEROIDS ON BRAIN LIPOCORTIN IMMUNOREACTIVITY. ACTA NEUROCHIR 101-103.
PARENTE L, NUTI S and SOLITO E (1994). DEXAMETHASONE INDUCES THE TRANSLOCATION OF LIPOCORTIN-1 TO THE MEMBRANE OF HUMAN MONOCYTIC U-937 CELLS. BRIT J PHARMACOL vol. 111, P72-P72.
SOLITO E, PALLA E, BENSI G, FASSINA G, MELLI M and PARENTE L (1994). IDENTIFICATION OF ACTIVE-SITES OF INTERLEUKIN-1-BETA BY LOOP SUBSTITUTION AND SITE-DIRECTED MUTAGENESIS. BRIT J PHARMACOL vol. 111, P31-P31.
1993
De Caterina R, Sicari R, Giannessi D, Paggiaro PL, Paoletti P, Lazzerini G, Bernini W, Solito E and Parente L (1993). Macrophage-specific eicosanoid synthesis inhibition and lipocortin-1 induction by glucocorticoids. J Appl Physiol (1985) vol. 75, (6) 2368-2375.
Palla E, Bensi G, Solito E, Buonamassa DT, Fassina G, Raugei G, Spano F, Galeotti C, Mora M and Domenighini M (1993). Loop substitution as a tool to identify active sites of interleukin-1 beta. J Biol Chem vol. 268, (18) 13486-13492.
BECHERUCCI C, PERRETTI M, SOLITO E, GALEOTTI CL and PARENTE L (1993). CONCEIVABLE DIFFERENCE IN THE ANTIINFLAMMATORY MECHANISMS OF LIPOCORTIN-1 AND LIPOCORTIN-5. MEDIAT INFLAMM vol. 2, (2) 109-113.
Rubartelli A, Bajetto A, Bonifaci N, Di Blas E, Solito E and Sitia R (1993). A novel way to get out of the cell. Cytotechnology vol. 11 Suppl 1, S37-S40.
Solito E, De Caterina R, Giannessi D, Paggiaro PL, Sicari R and Parente L (1993). Studies on the induction of lipocortin-1 by glucocorticoids. Ann Ist Super Sanita vol. 29, (3) 391-394.
Becherucci C, Perretti M, Solito E, Galeotti CL and Parente L (1993). Conceivable difference in the anti-inflammatory mechanisms of lipocortins 1 and 5. Mediators Inflamm vol. 2, (2) 109-113.
1992
Parente L, Galeotti CL, Ghiara P, Melli M, Mugridge KG and Solito E (1992). Mechanisms of IL-1 different biological activities. Studies using IL-1 muteins and IL-1 receptor antibodies. Elsevier Pharmacological Research vol. 26,
Parente L, Solito E, Giannessi P, Paggiari P, Sicari R and De Caterina R (1992). Inhibition of eicosanoid formation and lipocortin induction by glucocorticoids in human cell lines and in patients with inflammatory lung disease. Pharmacol Res vol. 26 Suppl 2, 44-45.
de Caterina R, Sicari R, Giannessi D, Paggiaro PL, Paoletti P, Lazzerini G, Bernini W, Solito E and Parente L (1992). Induction of synthesis of lipocortin-I and inhibition of eicosanoid production in inflammatory cells: Evidence for a cell selectivity in glucocorticoid action. Elsevier Thrombosis Research vol. 65,
Solito E, Raugei G, Melli M and Parente L (1992). Glucocorticoid effect on lipocortin mRNA expression in U-937 cells. Pharmacol Res vol. 25 Suppl 1, 13-14.
Perretti M, Solito E and Parente L (1992). Evidence that endogenous interleukin-1 is involved in leukocyte migration in acute experimental inflammation in rats and mice. Agents Actions vol. 35, (1-2) 71-78.
1991
Solito E, Raugei G, Melli M and Parente L (1991). Dexamethasone induces the expression of the mRNA of lipocortin 1 and 2 and the release of lipocortin 1 and 5 in differentiated, but not undifferentiated U-937 cells. FEBS Lett vol. 291, (2) 238-244.
SOLITO E, RAUGEI G, MELLI M and PARENTE L (1991). DEXAMETHASONE INDUCES THE EXPRESSION OF THE MESSENGER-RNA OF LIPOCORTIN-1 AND LIPOCORTIN-2 AND THE RELEASE OF LIPOCORTIN-1 AND LIPOCORTIN-5 IN DIFFERENTIATED, BUT NOT UNDIFFERENTIATED U-937 CELLS. FEBS LETT vol. 291, (2) 238-244.
Perretti M, Becherucci C, Mugridge KG, Solito E, Silvestri S and Parente L (1991). A novel anti-inflammatory peptide from human lipocortin 5. Br J Pharmacol vol. 103, (2) 1327-1332.
Solito E, Raugei G, Melli M and Parente L (1991). Effect of dexamethasone and phorbol myristate acetate on lipocortin 1, 2 and 5 mRNA and protein synthesis. Adv Prostaglandin Thromboxane Leukot Res vol. 21A, 291-294.
Boraschi D, Villa L, Ghiara P, Tagliabue A, Mengozzi M, Solito E, Parente L, Silvestri S, Van Damme J and Ghezzi P (1991). Mechanism of acute toxicity of IL-1 beta in mice. Eur Cytokine Netw vol. 2, (1) 61-67.
SOLITO E, RAUGEI G, MELLI M and PARENTE L (1991). EFFECT OF DEXAMETHASONE AND PHORBOL-MYRISTATE ACETATE ON LIPOCORTIN-1, LIPOCORTIN-2 AND LIPOCORTIN-5 MESSENGER-RNA AND PROTEIN-SYNTHESIS. ADV PROSTAG THROMB L vol. 21, 291-294.
1990
Parente L, Mugridge KG, Perretti M and Solito E (1990). In vitro and in vivo activation of phospholipase A2 by interleukin-1. Elsevier Pharmacological Research vol. 22,
Becherucci C, Solito E, Perretti M, Mugridge KG, Galeotti CL and Parente L (1990). Purification and biological activity of human lipocortin 2. Pharmacol Res vol. 22 Suppl 1, 29-30.
Parente L, Becherucci C, Perretti M, Solito E, Mugridge KG, Galeotti CL, Raugei G, Melli M and Sanso M (1990). Are the lipocortins the second messengers of the anti-inflammatory action of glucocorticoids? Prog Clin Biol Res vol. 349, 55-68.
1989
Solito E and Parente L (1989). Modulation of phospholipase A2 activity in human fibroblasts. Br J Pharmacol vol. 96, (3) 656-660.
1988
SOLITO E and PARENTE L (1988). ACTIVATION OF PHOSPHOLIPASE-A2 BY INTERLEUKIN-1 IN HUMAN-FIBROBLASTS. LYMPHOKINE RES vol. 7, (3) 261-261.
1985
Solito E, Busoni P and Bini L (1985). [Relational perspective in a district service for the substance-dependent]. Minerva Psichiatr vol. 26, (3) 267-269.
Grants
BBI immunometabolic aging
Egle Solito
£10,505 WHRL William Harvey Research Limited (01-05-2019 - 31-12-2023)
Egle Solito
£10,505 WHRL William Harvey Research Limited (01-05-2019 - 31-12-2023)
BHF : 4 Year PhD Studentship Award - 4th Intake
Egle Solito
£36,000 BHF British Heart Foundation (01-10-2016 - 30-09-2021)
Egle Solito
£36,000 BHF British Heart Foundation (01-10-2016 - 30-09-2021)