Research

Organ-on-a-chip, Growth plate, Biomechanics, Stem cells, Microfluidics, Biomaterials

Underpinning Bioengineering, Musculoskeletal Models

Interests

Mechanical stimulation plays a pivotal role in numerous tissues in health and disease and has been proposed as an important component of organ-chips for preclinical drug testing. Some organ-chip platforms (e.g., Emulate) allow the application of mechanical strain on the cells, but the strain fields in these organ-chips are poorly understood. Moreover, it is currently unclear how mechanical strain influences the behaviour of cells within these organ-chips and hence the importance of including physiological biomechanical loading within these complex in vitro models. My main interest thus lies in understanding the critical interplay between mechanical strain and biological response in organ-chips.