Prof Hazel Screen
Professor of Biomedical Engineering
Co-Director of the Centre for Predictive in vitro Models
Director of the UK Organ-on-a-Chip Technologies Network (2018-2022)
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
musculoskeletal, mechanobiology, organ-on-a-chip, matrix, tendon, joint
Interests
Hazel Screen is a Professor of Biomedical Engineering working with organ-chip technology to explore the aetiology of health and disease, with a particular focus on mechanically functional tissues such as those in the musculoskeletal or cardiovascular systems. She focuses on healthy and pathological tissue structure-function relationships and their impact on cell metabolism, developing new models within which to explore fundamental tissue mechanics and biology questions as well as routes to new treatments and drug development. She co-directs the UK Organ-on-a-Chip Technologies Network as well as the Centre for Predictive in vitro Models and Queen Mary & Emulate Organs-on-Chips Centre at QMUL. She plays an active role in helping to shape the field and associated policy and regulation, as well as driving her own research group, funded from a range of UKRI and charity sources.Publications
Publications of specific relevance to Predictive in vitro Models2024
Screen HRC (2024). TENDON HEALTH AND DISEASE: EXPLORING THE INTERFASCICULAR NICHE. British Editorial Society of Bone & Joint Surgery Orthopaedic Proceedings vol. 106-B, (SUPP_2) 105-105. 2023
Thompson CL, Hopkins T, Bevan C, Screen HRC, Wright KT and Knight MM (2023). Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment. IOP Publishing Biomedical Materials vol. 18, (6) Lake SP, Snedeker JG, Wang VM, Awad H, Screen HRC and Thomopoulos S (2023). Guidelines for ex vivo mechanical testing of tendon. Wiley Journal of Orthopaedic Research® vol. 41, (10) 2105-2113. Zamboulis DE, Marr N, Lenzi L, Birch HL, Screen HRC, Clegg PD and Thorpe CT (2023). The Interfascicular Matrix of Energy Storing Tendons Houses Heterogenous Cell Populations Disproportionately Affected by Aging. Buck Institute for Age Research Aging and Disease Shivapatham G, Richards S, Bamber J, Screen H and Morrissey D (2023). Ultrasound Measurement of Local Deformation in the Human Free Achilles Tendon Produced by Dynamic Muscle-Induced Loading: A Systematic Review. Elsevier Ultrasound in Medicine and Biology Waugh CM, Mousavizadeh R, Lee J, Screen HRC and Scott A (2023). Mild hypercholesterolemia impacts achilles sub-tendon mechanical properties in young rats. BioMed Central BMC Musculoskeletal Disorders vol. 24, (1) Gains CC, Giannapoulos A, Zamboulis DE, Lopez-Tremoleda J and Screen HRC (2023). Development and application of a novel in vivo overload model of the Achilles tendon in rat. Elsevier Journal of Biomechanics vol. 151, Tayfur A, Şendil A, Sezik AÇ, Jean-François K, Sancho I, Le Sant G, Dönmez G, Duman M, Tayfur B, Pawson J, Uzlaşır S, Miller SC, Screen H and Morrissey D (2023). Self-reported bio-psycho-social factors partially distinguish patellar tendinopathy from other knee problems and explain patellar tendinopathy severity in jumping athletes: A case-control study. Elsevier Physical Therapy in Sport vol. 61, 57-65. Waugh CM, Mousavizadeh R, Lee J, Screen HRC and Scott A (2023). The impact of mild hypercholesterolemia on injury repair in the rat patellar tendon. Wiley Journal of Orthopaedic Research Nolan J, Pearce OMT, Screen HRC, Knight MM and Verbruggen SW (2023). Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK. MDPI Cancers vol. 15, (3) 2022
Candarlioglu PL, Dal Negro G, Hughes D, Balkwill F, Harris K, Screen H, Morgan H, David R, Beken S, Guenat O, Rowan W and Amour A (2022). Organ-on-a-chip: current gaps and future directions. Portland Press Biochemical Society Transactions vol. 50, (2) 665-673. Tayfur A, Sendil A, Sezik AC, Jean-François K, Sancho I, Le Sant G, Donmez G, Duman M, Tayfur B, Pawson J, Uzlasir S, Miller SC, Screen H and Morrissey D (2022). Self-reported bio-psycho-social factors partially distinguish patellar tendinopathy from other knee problems and explain severity in jumping athletes: A case–control study. Elsevier Physiotherapy vol. 114, e105-e106. Tayfur A, Zenner D, Miller SC, Screen H and Morrissey D (2022). Outcome predictors for recovery of patellar tendinopathy in jumping athletes: an international prospective cohort study. BMJ Journals BMJ Open 2021
Tayfur A, Haque A, Salles JI, Malliaras P, Screen H and Morrissey D (2021). Are Landing Patterns in Jumping Athletes Associated with Patellar Tendinopathy? A Systematic Review with Evidence Gap Map and Meta-analysis. Springer Nature Sports Medicine vol. 52, (1) 123-137. Squier K, Scott A, Hunt MA, Brunham LR, Wilson DR, Screen H and Waugh CM (2021). The effects of cholesterol accumulation on Achilles tendon biomechanics: A cross-sectional study. Public Library of Science (PLoS) PLOS ONE vol. 16, (9) Zahradnik TM, Cresswell M, Squier K, Waugh C, Brunham L, Screen H and Scott A (2021). Can Achilles tendon xanthoma be distinguished from Achilles tendinopathy using Dixon method MRI? A cross-sectional exploratory study. Springer Nature BMC Musculoskeletal Disorders vol. 22, (1) Patel D, Zamboulis DE, Spiesz EM, Birch HL, Clegg PD, Thorpe CT and Screen HRC (2021). Structure-function specialisation of the interfascicular matrix in the human achilles tendon. Elsevier Acta Biomaterialia vol. 131, 381-390. Waugh C, Mousavizadeh R, Screen H and Scott A (2021). The Impact of Hypercholesterolemia on Tendon Injury Repair. Wiley The FASEB Journal vol. 35, (S1) Godinho MSC, Thorpe CT, Greenwald SE and Screen H (2021). Elastase treatment of tendon specifically impacts the mechanical properties of the interfascicular matrix. Elsevier Acta Biomaterialia Siebert T, Screen HRC and Rode C (2021). 8 Computational modelling of muscle, tendon, and ligaments biomechanics. Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System Elsevier 2020
Zamboulis D, Thorpe CT, Ashraf Kharaz Y, Birch HL, Clegg PD and Screen H (2020). Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix. eLife Sciences Publications Ltd eLife Gains C, Correia J, Baan G, Noort W, Screen H and Maas H (2020). Force Transmission Between the Gastrocnemius and Soleus Sub-Tendons of the Achilles Tendon in Rat. Frontiers Media Frontiers in Bioengineering and Biotechnology vol. 8, 700-700. Tayfur A, Salles JI, Miller SC, Screen H and Morrissey D (2020). Patellar tendinopathy outcome predictors in jumping athletes: feasibility of measures for a cohort study. Elsevier Physical Therapy in Sport vol. 44, 75-84. Shearer T, Parnell WJ, Lynch B, Screen HRC and David Abrahams I (2020). A Recruitment Model of Tendon Viscoelasticity That Incorporates Fibril Creep and Explains Strain-Dependent Relaxation. ASME International Journal of Biomechanical Engineering vol. 142, (7) 2019
Chineye U, Jones E, Riley G, Morrissey D and Screen H (2019). An in vitro investigation into the effects of 10Hz cyclic loading on tenocyte metabolism. Wiley Scandinavian Journal of Medicine and Science in Sports Anssari-Benam A, Screen HRC and Bucchi A (2019). Insights into the micromechanics of stress-relaxation and creep behaviours in the aortic valve. J Mech Behav Biomed Mater vol. 93, 230-245. 2018
Liu R, Becer CR and Screen HRC (2018). Guided Cell Attachment via Aligned Electrospinning of Glycopolymers. Macromolecular Bioscience vol. 18, (12) Capilnasiu A, Hadjicharalambous M, Fovargue D, Patel D, Holub O, Bilston L, Screen H, Sinkus R and Nordsletten D (2018). Magnetic resonance elastography in nonlinear viscoelastic materials under load. Springer Nature Biomechanics and Modeling in Mechanobiology vol. 18, (1) 111-135. Rowson DT, Shelton JC, Screen HRC and Knight MM (2018). Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6. Springer Nature Scientific Reports vol. 8, (1) Cook JL and Screen HR (2018). Tendon pathology: Have we missed the first step in the development of pathology? J Appl Physiol (1985) Clegg P, Zamboulis D and Screen H (2018). Postnatal Development of the Functional Specialization of the Equine Superficial Digital Flexor Tendon. Thieme Veterinary and Comparative Orthopaedics and Traumatology vol. 31, (S 02) a1-a25. PATEL D, Sharma S, SCREEN HRC and BRYANT S (2018). Effects of cell adhesion motif, fiber stiffness, and cyclic strain on tenocyte gene expression in a tendon mimetic fiber composite hydrogel. Elsevier Biochemical and Biophysical Research Communications Spiesz EM, Thorpe CT, Thurner PJ and Screen HRC (2018). Structure and collagen crimp patterns of functionally distinct equine tendons, revealed by quantitative polarised light microscopy (qPLM). Acta Biomaterialia vol. 70, 281-292. 2017
Godinho MSC, Thorpe CT, Greenwald SE and Screen HRC (2017). Elastin is Localised to the Interfascicular Matrix of Energy Storing Tendons and Becomes Increasingly Disorganised With Ageing. Scientific Reports vol. 7, (1) Shearer T, Thorpe CT, Spiesz E and SCREEN HRC (2017). The relative compliance of energy-storing tendons may be due to the helical fibril arrangement of their fascicles. Royal Society, The Journal of the Royal Society Interface Thorpe CT, Riley GP, Birch HL, Clegg PD and Screen HRC (2017). Fascicles and the interfascicular matrix show decreased fatigue life with ageing in energy storing tendons. Acta Biomaterialia vol. 56, 58-64. BECER CR, Screen HRC, Patel D and Liu R (2017). A2B-Miktoarm Glycopolymer Fibers and Their Interactions with Tenocytes. American Chemical Society Bioconjugate Chemistry Patel D, Sharma S, Bryant SJ and Screen HRC (2017). Recapitulating the Micromechanical Behavior of Tension and Shear in a Biomimetic Hydrogel for Controlling Tenocyte Response. Advanced Healthcare Materials vol. 6, (4) Elyasigomari V, Lee DA, Screen HRC and SHAHEED MH (2017). Development of a two-stage gene selection method that incorporates a novel hybrid approach using the cuckoo optimization algorithm and harmony search for cancer classification. Journal of Biomedical Informatics vol. 67, (2017) 11-20. Anssari-Benam A, Bucchi A, SCREEN HRC and Evans SL (2017). A transverse isotropic viscoelastic constitutive model for aortic valve tissue. Royal Society, The: Open Access Royal Society Open Science 2016
Gupta HS and Screen HRC (2016). Structural Building Blocks of Soft Tissues: Tendons and Heart Valves. Material Parameter Identification and Inverse Problems in Soft Tissue Biomechanics Springer Nature Thorpe CT, Riley GP, Birch HL, Clegg PD and Screen HRC (2016). Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons. Acta Biomaterialia vol. 42, 308-315. Handsfield GG, Slane LC and Screen HRC (2016). Nomenclature of the tendon hierarchy: An overview of inconsistent terminology and a proposed size-based naming scheme with terminology for multi-muscle tendons. Journal of Biomechanics vol. 49, (13) 3122-3124. Mozdzen L, Thorpe S, SCREEN HRC and Harley B (2016). The effect of gradations in mineral content, matrix alignment, and applied strain on human mesenchymal stem cell morphology within collagen biomaterials. Wiley: 12 months Advanced healthcare materials Thorpe CT, Karunaseelan KJ, Ng Chieng Hin J, Riley GP, Birch HL, Clegg PD and Screen HRC (2016). Distribution of proteins within different compartments of tendon varies according to tendon type. Journal of Anatomy vol. 229, (3) 450-458. Rowson D, Knight MM and Screen HRC (2016). Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon. J Orthop Res vol. 34, (12) 2146-2153. Chaudhry S, Fernando R, Screen H, Waugh C, Tucker A and Morrissey D (2016). The use of medical infrared thermography in the detection of tendinopathy: a systematic review. Taylor & Francis Physical Therapy Reviews vol. 21, (2) 75-82. Thorpe CT, Peffers MJ, Simpson D, Halliwell E, Screen HRC and Clegg PD (2016). Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition. Springer Nature Scientific Reports vol. 6, (1) Thorpe CT and Screen HRC (2016). Tendon Structure and Composition. Springer Nature Advances in Experimental Medicine and Biology vol. 920, 3-10. Godinho MSC, Screen HRC, Greenwald SE and Thorpe CT (2016). Elastin is more abundant in energy storing tendons and is localised to the tendon interfascicular matrix. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY vol. 97, (6) A3-A4. 2015
Waugh CM, Morrissey D, Jones E, Riley GP, Langberg H and Screen HRC (2015). In vivo biological response to extracorporeal shockwave therapy in human tendinopathy. European Cells and Materials eCells & Materials vol. 29, 268-280. Spiesz EM, Thorpe CT, Chaudhry S, Riley GP, Birch HL, Clegg PD and Screen HRC (2015). Tendon extracellular matrix damage, degradation and inflammation in response to in vitro overload exercise. Wiley Journal of Orthopaedic Research® vol. 33, (6) 889-897. Screen HRC, Berk DE, Kadler KE, Ramirez F and Young MF (2015). Tendon Functional Extracellular Matrix. Wiley Journal of Orthopaedic Research® vol. 33, (6) 793-799. Thorpe CT, Godinho MSC, Riley GP, Birch HL, Clegg PD and Screen HRC (2015). The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons. Elsevier Journal of the Mechanical Behavior of Biomedical Materials vol. 52, 85-94. Chaudhry S, Morrissey D, Woledge RC, Bader DL and Screen HRC (2015). Eccentric and Concentric Exercise of the Triceps Surae: An in Vivo Study of Dynamic Muscle and Tendon Biomechanical Parameters. Human Kinetics Journal of Applied Biomechanics vol. 31, (2) 69-78. Chaudhry S, Morrissey D, Woledge RC, Bader DL and Screen HR (2015). Eccentric and concentric exercise of the triceps surae: an in vivo study of dynamic muscle and tendon biomechanical parameters. J Appl Biomech vol. 31, (2) 69-78. Chaudhry S, Morrissey D, Woledge RC, Bader DL and Screen HRC (2015). Eccentric and Concentric Exercise of the Triceps Surae: An in Vivo Study of Dynamic Muscle and Tendon Biomechanical Parameters. J Appl Biomech vol. 31, (2) 69-78. Mani-Babu S, Morrissey D, Waugh C, Screen H and Barton C (2015). The effectiveness of extracorporeal shock wave therapy in lower limb tendinopathy: a systematic review. Am J Sports Med vol. 43, (3) 752-761. Thorpe CT, Spiesz EM, Chaudhry S, Screen HRC and Clegg PD (2015). Science in brief: Recent advances into understanding tendon function and injury risk. Wiley Equine Veterinary Journal vol. 47, (2) 137-140. Elyasigomari V, Mirjafari MS, Screen HRC and Shaheed MH (2015). Cancer classification using a novel gene selection approach by meansof shuffling based on data clustering with optimization. ELSEVIER Applied Soft Computing vol. 35, (2015) 43-51. Thorpe CT, Birch HL, Clegg PD and Screen HRC (2015). Tendon Physiology and Mechanical Behavior: Structure-Function Relationships. Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes Thorpe CT, Birch HL, Clegg PD and Screen HRC (2015). Chapter 1 Tendon Physiology and Mechanical Behavior Structure–Function Relationships. Tendon Regeneration Elsevier 2014
Thorpe CT, Chaudhry S, Lei II, Varone A, Riley GP, Birch HL, Clegg PD and Screen HRC (2014). Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation. Wiley Scandinavian Journal of Medicine and Science in Sports vol. 25, (4) e381-e391. Shepherd JH, Riley GP and Screen HRC (2014). Early stage fatigue damage occurs in bovine tendon fascicles in the absence of changes in mechanics at either the gross or micro-structural level. J Mech Behav Biomed Mater vol. 38, 163-172. Peffers MJ, Thorpe CT, Collins JA, Eong R, Wei TKJ, Screen HRC and Clegg PD (2014). Proteomic analysis reveals age-related changes in tendon matrix composition, with age- and injury-specific matrix fragmentation. J Biol Chem vol. 289, (37) 25867-25878. Patel D, Bryant S, Riley G, Jones E and Screen H (2014). 78 Human Tenocyte Metabolism Under Pathological And Physiological Loading Conditions. BMJ British Journal of Sports Medicine vol. 48, (Suppl 2) a51-a51. Spiesz EM, Thorpe CT, Chaudhry S, Riley GP, Birch HL, Clegg PD and Screen HR (2014). 98 Early Inflammatory Response Of Tenocytes To Overload. BMJ British Journal of Sports Medicine vol. 48, (Suppl 2) a63-a64. Thorpe C, Peffers M, Simpson D, Halliwell E, Screen H and Clegg P (2014). 104 Characterisation Of The Proteome Of The Tendon Interfascicular Matrix. BMJ British Journal of Sports Medicine vol. 48, (Suppl 2) a68-a68. Rowson D, Knight M and Screen H (2014). 89 Primary Cilia In Tenocytes From The Inter-fascicular Matrix And The Fascicular Matrix. BMJ British Journal of Sports Medicine vol. 48, (Suppl 2) a58-a59. Morrissey D, Morton S, Anuj CA and Screen H (2014). Achillessehnentendinopathie. Thieme Sportphysio vol. 02, (03) 105-111. Thorpe CT, Riley GP, Birch HL, Clegg PD and Screen HRC (2014). Effect of fatigue loading on structure and functional behaviour of fascicles from energy-storing tendons. Acta Biomater vol. 10, (7) 3217-3224. Waugh C, Jones E, Riley G, Langberg H, Morrissey D and Screen H (2014). The effects of extracorporeal shockwave therapy on matrix metalloprotease activity in tendinopathy (1046.8). Wiley The FASEB Journal vol. 28, (S1) Thorpe CT, Riley GP, Birch HL, Clegg PD and Screen HRC (2014). Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading. Journal of the Royal Society Interface vol. 11, (92) Shepherd JH, Legerlotz K, Demirci T, Klemt C, Riley GP and Screen HRC (2014). Functionally distinct tendon fascicles exhibit different creep and stress relaxation behaviour. Proc Inst Mech Eng H vol. 228, (1) 49-59. Smith R, McIlwraith W, Schweitzer R, Kadler K, Cook J, Caterson B, Dakin S, Heinegard D, Screen H, Stover S, Crevier-Denoix N, Clegg P, Collins M, Little C, Frisbie D, Kjaer M, van Weeren R, Werpy N, Denoix J-M, Carr A, Goldberg A, Bramlage L, Smith M and Nixon A (2014). Advances in the understanding of tendinopathies: A report on the Second Havemeyer Workshop on equine tendon disease. EQUINE VETERINARY JOURNAL vol. 46, (1) 4-9. 2013
Thorpe CT, Birch HL, Clegg PD and Screen HRC (2013). The role of the non-collagenous matrix in tendon function. Int J Exp Pathol vol. 94, (4) 248-259. Shepherd JH and Screen HRC (2013). Fatigue loading of tendon. Int J Exp Pathol vol. 94, (4) 260-270. Thorpe CT, Klemt C, Riley GP, Birch HL, Clegg PD and Screen HRC (2013). Helical sub-structures in energy-storing tendons provide a possible mechanism for efficient energy storage and return. Acta Biomater vol. 9, (8) 7948-7956. Legerlotz K, Riley GP and Screen HRC (2013). GAG depletion increases the stress-relaxation response of tendon fascicles, but does not influence recovery. Acta Biomater vol. 9, (6) 6860-6866. Anssari-Benam A, Legerlotz K, Bader DL and Screen HRC (2013). Response to letter to the editor: End effects in mechanical testing of biomaterials. Journal of Biomechanics vol. 46, (5) Legerlotz K, Jones GC, Screen HRC and Riley GP (2013). Cyclic loading of tendon fascicles using a novel fatigue loading system increases interleukin-6 expression by tenocytes. Scandinavian Journal of Medicine and Science in Sports vol. 23, (1) 31-37. Thorpe CT, Udeze CP, Birch HL, Clegg PD and Screen HR (2013). Capacity for sliding between tendon fascicles decreases with ageing in injury prone equine tendons: a possible mechanism for age-related tendinopathy? Eur Cell Mater vol. 25, 48-60. Screen HRC, Toorani S and Shelton JC (2013). Microstructural stress relaxation mechanics in functionally different tendons. Med Eng Phys vol. 35, (1) 96-102. Screen HRC, Toorani S and Shelton JC (2013). Microstructural stress relaxation mechanics in functionally different tendons. Medical Engineering and Physics vol. 35, (1) 96-102. Anssari-Benam A, Legerlotz K, Bader DL and Screen HRC (2013). Response to letter to the editor: End effects in mechanical testing of biomaterials. Journal of Biomechanics Thorpe CT, Klemt C, Riley GP, Birch HL, Clegg PD and Screen HRC (2013). Helical sub-structures in energy-storing tendons provide a possible mechanism for efficient energy storage and return. Acta Biomaterialia vol. 9, (8) 7948-7956. 2012
Thorpe CT, Udeze CP, Birch HL, Clegg PD and Screen HRC (2012). Specialization of tendon mechanical properties results from interfascicular differences. Journal of the Royal Society Interface vol. 9, (76) 3108-3117. Anssari-Benam A, Legerlotz K, Bader DL and Screen HRC (2012). On the specimen length dependency of tensile mechanical properties in soft tissues: gripping effects and the characteristic decay length. J Biomech vol. 45, (14) 2481-2482. Screen HRC and Tanner KE (2012). Structure and Biomechanics of Biological Composites. Wiley Encyclopedia of Composites Wiley Anssari-Benam A, Gupta HS and Screen HRC (2012). Strain transfer through the aortic valve. Journal of Biomechanical Engineering vol. 134, (6) Morrissey D, Graham J, Screen H, Sinha A, Small C, Twycross-Lewis R and Woledge R (2012). Coronal plane hip muscle activation in football code athletes with chronic adductor groin strain injury during standing hip flexion. Manual Therapy vol. 17, (2) 145-149. Legerlotz K, Jones ER, Screen HRC and Riley GP (2012). Increased expression of IL-6 family members in tendon pathology. RHEUMATOLOGY vol. 51, (7) 1161-1165. 2011
Screen HRC, Seto J, Krauss S, Boesecke P and Gupta HS (2011). Extrafibrillar diffusion and intrafibrillar swelling at the nanoscale are associated with stress relaxation in the soft collagenous matrix tissue of tendons. Soft Matter vol. 7, (23) 11243-11251. Simms C, Screen H and Evans S (2011). Nonlinearities in soft tissue strain. J Mech Behav Biomed Mater vol. 4, (8) Anssari-Benam A, Bader DL and Screen HRC (2011). Anisotropic time-dependant behaviour of the aortic valve. Journal of the Mechanical Behavior of Biomedical Materials vol. 4, (8) 1603-1610. Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC (2011). Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. Proc Inst Mech Eng H vol. 225, (8) 821-830. Morrissey D, Roskilly A, Twycross-Lewis R, Isinkaye T, Screen H, Woledge R and Bader D (2011). The effect of eccentric and concentric calf muscle training on Achilles tendon stiffness. Clinical Rehabilitation vol. 25, (3) 238-247. Anssari-Benam A, Bader DL and Screen HRC (2011). A combined experimental and modelling approach to aortic valve viscoelasticity in tensile deformation. J MATER SCI-MATER M vol. 22, (2) 253-262. Sweeney E, Chaudhury S, Screen H, Woledge R, Bader D, Maffulli N and Morrissey D (2011). The effect of eccentric and concentric loading speed on the normal achilles tendon: an in vivo biomechanical study. BMJ British Journal of Sports Medicine vol. 45, (2) Chaudhry S, Screen HRC, Woledge RC, Bader D and Morrissey D (2011). The effect of loading speed on the force frequency spectrum during eccentric & concentric calf exercise. BMJ British Journal of Sports Medicine vol. 45, (2) Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC (2011). Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. P I MECH ENG H vol. 225, (H8) 821-830. 2010
Legerlotz K, Riley GP and Screen HRC (2010). Specimen dimensions influence the measurement of material properties in tendon fascicles. Journal of Biomechanics vol. 43, (12) 2274-2280. Screen HRC, Byers S, Lynn AD, Nguyen V, Patel D and Bryant SJ (2010). Characterization of a novel fiber composite material for mechanotransduction research of fibrous connective tissues. Advanced Functional Materials vol. 20, (5) 738-747. Gupta HS, Seto J, Krauss S, Boesecke P and Screen HRC (2010). In situ multi-level analysis of viscoelastic deformation mechanisms in tendon collagen. Journal of Structural Biology vol. 169, (2) 183-191. 2009
Screen HRC and Evans SL (2009). Measuring strain distributions in the tendon using confocal microscopy and finite elements. J STRAIN ANAL ENG vol. 44, (5) 327-335. SCREEN H (2009). Hierarchical approaches to understanding tendon mechanics. Japan Society of Mechanical Engineers Journal of Biomechanical Science and Engineering vol. 4, (4) 481-499. 2008
Toorani S, Shelton JC and Screen HRC (2008). Characterizing structure-function relationships in tendon. 8th World Biomaterials Congress 2008 vol. 2, Screen HRC (2008). Investigating load relaxation mechanics in tendon. Journal of the Mechanical Behavior of Biomedical Materials vol. 1, (1) 51-58. 2007
Cheng VWT and Screen HRC (2007). The micro-structural strain response of tendon. J MATER SCI vol. 42, (21) 8957-8965. SCREEN HRC and Cheng VWT (2007). Strain mechanisms in tendon fascicles. J.Mat.Sci. vol. 21, 8957-8965. 2006
Screen HRC, Chhaya VH, Greenwald SE, Bader DL, Lee DA and Shelton JC (2006). The influence of swelling and matrix degradation on the microstructural integrity of tendon. Acta Biomater vol. 2, (5) 505-513. 2005
Screen HRC, Bader DL, Shelton JC and Lee DA (2005). Cyclic mechanical conditioning of isolated tendon fascicles results in an upregulation of collagen production. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 193-194. Screen HRC, Shelton JC, Bader DL and Lee DA (2005). Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles. Biochem Biophys Res Commun vol. 336, (2) 424-429. Screen HRC, Shelton JC, Chhaya VH, Kayser MV, Bader DL and Lee DA (2005). The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles. Ann Biomed Eng vol. 33, (8) 1090-1099. (2005). British Society for Matrix Biology Autumn Meeting Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UK. Wiley International Journal of Experimental Pathology vol. 86, (3) a1-a56. 2004
Bader DL, Shelton JC, Lee DA and SCREEN HRC (2004). Local Strain Measurement within Tendon. Strain vol. 40, (4) 157-163. Screen HRC, Lee DA, Bader DL and Shelton JC (2004). An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties. Proc Inst Mech Eng H vol. 218, (2) 109-119. 2003
Screen HRC, Lee DA, Bader DL and Shelton JC (2003). Development of a technique to determine strains in tendons using the cell nuclei. Biorheology vol. 40, (1-3) 361-368. 2002
BADER DL, Shelton JC, Lee DA and Screen HRC (2002). Development of a technique to determine strains in tendons using the cell nuclei. Biorheology vol. 40, 361-368. Bader DL, Shelton JC, Lee DA and SCREEN HRC (2002). Non-collagenous matrix components influence the micromechanical environment of tenocytes within tendon fascicles subjected to tensile strain. Eur. Cells Mat. vol. 4:S1, 41-42. Bader DL, Shelton JC, LEE DA and Screen HRC (2002). Non-collagenous matrix components influence the micro-mechanical environment of tenocytes within tendon fasciles subjected to tensile strain. Eur. Cells Materials vol. 4 suppl 1, 41-42. Grants
Grants of specific relevance to Predictive in vitro ModelsOrgan-chip Facility: A world-class in vitro models facility for the UK community, reducing the barriers to adoption to drive animal replacementHazel Screen, Stefaan Verbruggen, Martin Knight, Julia Shelton, Timothy Hopkins and John Connelly
£573,537 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research (07-10-2024 - 14-03-2025)
(EPSRC CDT 2023) Next Generation Organ-on-a-Chip TechnologiesHazel Screen, Martin Knight, Thomas Iskratsch, Caroline Roney, Yi Sui, David Lee, Julia Shelton, Tsz Ho Tse, John Connelly, Adrian Biddle and Lucy Norling
£7,066,811 EPSRC Engineering and Physical Sciences Research Council (01-07-2024 - 30-09-2032)
APP13387: Micro-manufacturing of tissue patterned organ-chips for accelerated deployment of new medicinesMartin Knight, Hazel Screen, Julien Gautrot, Timothy Hopkins, John Connelly, Liisa Blowes and Xavier Griffin
£1,787,725 EPSRC Engineering and Physical Sciences Research Council (01-07-2024 - 30-06-2027)
Epithelial Exchange Surfaces – From organizing principles to novel culture models of the gatekeepers of the body - MSCA-2022-DN Martin KnightMartin Knight, Hazel Screen, Wen Wang, Clare Thompson and Cleo Bishop
£260,676 EPSRC - EU Scheme (01-12-2023 - 30-11-2027)
Incorporating physical cues in organ-chip modelsHazel Screen and Martin Knight
£20,000 Emulate Inc. (01-10-2022 - 30-09-2026)
Production of a Human Growth Plate Organ-Chip Model of Skeletal DevelopmentMartin Knight, Clare Thompson and Hazel Screen
£197,923 BBSRC Biotechnology and Biological Sciences Research Council (01-02-2023 - 31-07-2024)