Dr Isabel M Palacios
Lecturer
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
tissue architecture, cytoskeletons, human stem cells, drosophila, organoids
Interests
2D and 3D cell culture models (both human and insect cells) and human organoidsPublications
2024
Essential conserved neuronal motors kinesin-1 and kinesin-3 regulate Aβ42 toxicity in vivoPalacios IM and Palacios De Castro MI
, Editors: biorxiv team . Biorxiv Journal
24-04-2024
2023
Constriction imposed by basement membrane regulates developmental cell migrationLópez EM, Kabanova A, Winkel A, Franze K, Palacios IM and Martín-Bermudo MD
Plos Biology, Public Library of Science vol. 21 (6)
28-06-2023
2020
The humble fruit fly is helping the African science community to thrivePalacios I, Vicente-Crespo M and Martín-Bermudo MD
Nature Reviews Molecular Cell Biology, Springer Nature vol. 21 (10), 558-559.
17-08-2020
Integrins regulate epithelial cell shape by controlling the architecture and mechanical properties of basal actomyosin networksSanta-Cruz Mateos C, Valencia-Expósito A, Palacios IM and Martín-Bermudo MD
Plos Genetics, Public Library of Science (Plos) vol. 16 (6), e1008717-e1008717.
01-06-2020
Optical flow analysis reveals that Kinesin-mediated advection impacts on the orientation of microtubules in the Drosophila oocyte.Drechsler M, Lang LF, Al-Khatib L, Dirks H, Burger M, Schönlieb C-B and Palacios IM
Molecular Biology of The Cell, American Society For Cell Biology, mbcE1908044-mbcE1908044.
08-04-2020
2019
YAP/Yorkie in the germline modulates the age-related decline of germline stem cells and niche cellsFrancis D, Chanana B, Fernandez B, Gordon B, Mak T and Palacios IM
Plos One, Public Library of Science (Plos) vol. 14 (4)
03-04-2019
2017
Active diffusion and advection in Drosophila oocytes result from the interplay of actin and microtubulesPALACIOS IM
Nature Communications, Nature Publishing Group vol. 8
15-11-2017
DrosAfrica: Building an African biomedical research community using DrosophilaMartín-Bermudo MD, Gebel L and Palacios IM
Seminars in Cell & Developmental Biology, Elsevier Bv vol. 70, 58-64.
30-08-2017
2016
α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epitheliumNg BF, Selvaraj GK, Santa-Cruz Mateos C, Grosheva I, Alvarez-Garcia I, Martín-Bermudo MD and Palacios IM
Journal of Cell Science, The Company of Biologists vol. 129 (9), e1.2-e1.2.
01-05-2016
α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epitheliumNg BF, Selvaraj GK, Santa-Cruz Mateos C, Grosheva I, Alvarez-Garcia I, Martín-Bermudo MD and Palacios IM
Development, The Company of Biologists vol. 143 (8), 1388-1399.
07-03-2016
Planar cell polarity: the Dachsous/Fat system contributes differently to the embryonic and larval stages of DrosophilaSaavedra P, Brittle A, Palacios IM, Strutt D, Casal J and Lawrence PA
Biology Open, The Company of Biologists vol. 5 (4), 397-408.
02-03-2016
2014
Hop-on hop-off: Polysomes take a tour of the cell on endosomesPalacios IM
Journal of Cell Biology, Rockefeller University Press vol. 204 (3), 287-289.
03-02-2014
Plasticity of both planar cell polarity and cell identity during the development of DrosophilaSaavedra P, Vincent J-P, Palacios IM, Lawrence PA and Casal J
Elife, Elife vol. 3
01-01-2014
Integrins regulate epithelial cell differentiation by modulating Notch activityGómez-Lamarca MJ, Cobreros-Reguera L, Ibáñez-Jiménez B, Palacios IM and Martín-Bermudo MD
Journal of Cell Science, The Company of Biologists vol. 127 (21), 4667-4678.
01-01-2014
The auto-inhibitory domain and ATP-independent microtubulebinding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germlineWilliams LS, Ganguly S, Loiseau P, Ng BF and Palacios IM
Journal of Cell Science, The Company of Biologists vol. 127 (1), e1-e1.
01-01-2014
2013
How are spoken skills assessed in proficiency tests of general English as a Foreign Language? A preliminary surveyRoca-Varela ML and Palacios IM
International Journal of English Studies, Servicio De Publicaciones De La Universidad De Murcia vol. 13 (2), 53-68.
01-12-2013
The auto-inhibitory domain and ATP-independent microtubule-binding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germlineWilliams LS, Ganguly S, Loiseau P, Ng BF and Palacios IM
Development, The Company of Biologists vol. 141 (1), 176-186.
20-11-2013
2012
Nonsense-mediated mRNA decay: from mechanistic insights to impacts on human healthPalacios IM
Briefings in Functional Genomics, Oxford University Press (Oup) vol. 12 (1), 25-36.
11-11-2012
Cytoplasmic streaming in Drosophila oocytes varies with kinesin activity and correlates with the microtubule cytoskeleton architectureGanguly S, Williams LS, Palacios IM and Goldstein RE
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 109 (38), 15109-15114.
04-09-2012
2011
Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent mannerAvery P, Vicente-Crespo M, Francis D, Nashchekina O, Alonso CR and Palacios IM
Rna, Cold Spring Harbor Laboratory vol. 17 (4), 624-638.
11-02-2011
Nonsense-mediated mRNA decay and development: shoot the messenger to survive?Vicente-Crespo M and Palacios IM
Biochemical Society Transactions, Portland Press vol. 39 (1), 411-411.
19-01-2011
2010
Nonsense-mediated mRNA decay and development: shoot the messenger to survive?Vicente-Crespo M and Palacios IM
Biochemical Society Transactions, Portland Press vol. 38 (6), 1500-1505.
24-11-2010
Drosophila PAT1 is required for Kinesin-1 to transport cargo and to maximize its motilityLoiseau P, Davies T, Williams LS, Mishima M and Palacios IM
Journal of Cell Science, The Company of Biologists vol. 123 (16), e1-e1.
15-08-2010
2007
The Salvador-Warts-Hippo Pathway Is Required for Epithelial Proliferation and Axis Specification in DrosophilaMeignin C, Alvarez-Garcia I, Davis I and Palacios IM
Current Biology, Elsevier vol. 17 (21), 1871-1878.
25-10-2007
How does an mRNA find its way? Intracellular localisation of transcriptsPalacios IM
Seminars in Cell and Developmental Biology, Elsevier vol. 18 (2), 163-170.
26-01-2007
2004
An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decayPalacios IM, Gatfield D, St Johnston D and Izaurralde E
Nature, Springer Nature vol. 427 (6976), 753-757.
01-02-2004
2003
Barentsz, a New Component of the Staufen-Containing Ribonucleoprotein Particles in Mammalian Cells, Interacts with Staufen in an RNA-Dependent MannerMacchi P, Kroening S, Palacios IM, Baldassa S, Grunewald B, Ambrosino C, Goetze B, Lupas A, St. Johnston D and Kiebler M
Journal of Neuroscience, Society For Neuroscience vol. 23 (13), 5778-5788.
02-07-2003
2002
Kinesin light chain-independent function of the Kinesin heavy chain in cytoplasmic streaming and posterior localisation in theDrosophila oocytePalacios IM and St Johnston D
Development, The Company of Biologists vol. 129 (23), 5473-5485.
01-12-2002
Drosophila 14-3-3/PAR-5 Is an Essential Mediator of PAR-1 Function in Axis FormationBenton R, Palacios IM and St Johnston D
Developmental Cell, Elsevier vol. 3 (5), 659-671.
01-11-2002
RNA Processing: Splicing and the Cytoplasmic Localisation of mRNAPalacios IM
Current Biology, Elsevier vol. 12 (2), r50-r52.
01-01-2002
2001
GETTING THE MESSAGE ACROSS: The Intracellular Localization of mRNAs in Higher EukaryotesPalacios IM and Johnston DS
Annual Review of Cell and Developmental Biology, Annual Reviews vol. 17 (1), 569-614.
01-11-2001
Dimerization of the 3′UTR of bicoid mRNA involves a two-step mechanism11Edited by J. DoudnaWagner C, Palacios I, Jaeger L, St Johnston D, Ehresmann B, Ehresmann C and Brunel C
Journal of Molecular Biology, Elsevier vol. 313 (3), 511-524.
01-10-2001
Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior polevan Eeden FJM, Palacios IM, Petronczki M, Weston MJD and St Johnston D
Journal of Cell Biology, Rockefeller University Press vol. 154 (3), 511-524.
30-07-2001
RNA Intracellular TransportPalacios I and Izaurralde E
In Encyclopedia of Life Sciences, Wiley
19-04-2001
1997
Nuclear import of U snRNPs requires importin βPalacios I, Hetzer M, Adam SA and Mattaj IW
The Embo Journal, Springer Nature vol. 16 (22), 6783-6792.
15-11-1997
Chapter 23 In Vitro Systems for the Reconstitution of snRNP and Protein Nuclear ImportDingwall C and Palacios I
Methods in Cell Biology, Elsevier vol. 53, 517-543.
01-01-1997
1996
RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus.Palacios I, Weis K, Klebe C, Mattaj IW and Dingwall C
Journal of Cell Biology, Rockefeller University Press vol. 133 (3), 485-494.
01-05-1996
Mutational analysis identifies functional domains in the influenza A virus PB2 polymerase subunitPerales B, de la Luna S, Palacios I and Ortín J
Journal of Virology, American Society For Microbiology vol. 70 (3), 1678-1686.
01-03-1996
1995
Nuclear retention of RNA as a mechanism for localization.Boelens WC, Palacios I and Mattaj IW
Rna vol. 1 (3), 273-283.
01-05-1995
Grants
Highthroughput Light Sheet Microscopy: Imaging Across ScalesViji Draviam Sastry, Caroline Brennan, Vidya Darbari, Jose Martin Duran, Ivan Kadurin, Isabel M Palacios, Richard Pickersgill, Sarah McClelland, Tyson Sharp and Martin Knight
£386,205 MRC Medical Research Council
01-10-2022 - 31-03-2023
A confocal microscope for multidisciplinary dynamic studies of complex biological systemsConrad Mullineaux, Caroline Brennan, Alexandre De Mendoza Soler, Viji Draviam Sastry, Maurice Elphick, Christoph Engl, Isabel M Palacios, Matteo Palma, Marina Resmini, Alexander Ruban, Peter Thorpe, Angelika Stollewerk, Jose Martin Duran, Paulo Baptista Ribeiro, Susana Godinho, Richard Grose, Stephanie Kermorgant, Peter McCormick and Tyson Sharp
£390,834 BBSRC Biotechnology and Biological Sciences Research Council
01-08-2022 - 31-07-2023