Dr Isabel M Palacios
Lecturer
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
tissue architecture, cytoskeletons, human stem cells, drosophila, organoids
Interests
2D and 3D cell culture models (both human and insect cells) and human organoidsPublications
2024
Palacios IM and Palacios De Castro MI (2024). Essential conserved neuronal motors kinesin-1 and kinesin-3 regulate Aβ42 toxicity in vivo., Editors: biorxiv team . bioRxiv journal 2023
López EM, Kabanova A, Winkel A, Franze K, Palacios IM and Martín-Bermudo MD (2023). Constriction imposed by basement membrane regulates developmental cell migration. Public Library of Science PLoS Biology vol. 21, (6) 2020
Palacios I, Vicente-Crespo M and Martín-Bermudo MD (2020). The humble fruit fly is helping the African science community to thrive. Springer Nature Nature Reviews Molecular Cell Biology vol. 21, (10) 558-559. Santa-Cruz Mateos C, Valencia-Expósito A, Palacios IM and Martín-Bermudo MD (2020). Integrins regulate epithelial cell shape by controlling the architecture and mechanical properties of basal actomyosin networks. Public Library of Science (PLoS) PLOS Genetics vol. 16, (6) e1008717-e1008717. Drechsler M, Lang LF, Al-Khatib L, Dirks H, Burger M, Schönlieb C-B and Palacios IM (2020). Optical flow analysis reveals that Kinesin-mediated advection impacts on the orientation of microtubules in the Drosophila oocyte. American Society for Cell Biology Molecular Biology of the Cell mbcE1908044-mbcE1908044. 2019
Francis D, Chanana B, Fernandez B, Gordon B, Mak T and Palacios IM (2019). YAP/Yorkie in the germline modulates the age-related decline of germline stem cells and niche cells. Public Library of Science (PLoS) PLOS ONE vol. 14, (4) 2017
PALACIOS IM (2017). Active diffusion and advection in Drosophila oocytes result from the interplay of actin and microtubules. Nature Publishing Group Nature Communications vol. 8, Martín-Bermudo MD, Gebel L and Palacios IM (2017). DrosAfrica: Building an African biomedical research community using Drosophila. Elsevier BV Seminars in Cell & Developmental Biology vol. 70, 58-64. 2016
Ng BF, Selvaraj GK, Santa-Cruz Mateos C, Grosheva I, Alvarez-Garcia I, Martín-Bermudo MD and Palacios IM (2016). α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epithelium. The Company of Biologists Journal of Cell Science vol. 129, (9) e1.2-e1.2. Ng BF, Selvaraj GK, Santa-Cruz Mateos C, Grosheva I, Alvarez-Garcia I, Martín-Bermudo MD and Palacios IM (2016). α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epithelium. The Company of Biologists Development vol. 143, (8) 1388-1399. Saavedra P, Brittle A, Palacios IM, Strutt D, Casal J and Lawrence PA (2016). Planar cell polarity: the Dachsous/Fat system contributes differently to the embryonic and larval stages of Drosophila. The Company of Biologists Biology Open vol. 5, (4) 397-408. 2014
Palacios IM (2014). Hop-on hop-off: Polysomes take a tour of the cell on endosomes. Rockefeller University Press Journal of Cell Biology vol. 204, (3) 287-289. Saavedra P, Vincent J-P, Palacios IM, Lawrence PA and Casal J (2014). Plasticity of both planar cell polarity and cell identity during the development of Drosophila. eLife eLife vol. 3, Gómez-Lamarca MJ, Cobreros-Reguera L, Ibáñez-Jiménez B, Palacios IM and Martín-Bermudo MD (2014). Integrins regulate epithelial cell differentiation by modulating Notch activity. The Company of Biologists Journal of Cell Science vol. 127, (21) 4667-4678. Williams LS, Ganguly S, Loiseau P, Ng BF and Palacios IM (2014). The auto-inhibitory domain and ATP-independent microtubulebinding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germline. The Company of Biologists Journal of Cell Science vol. 127, (1) e1-e1. 2013
Roca-Varela ML and Palacios IM (2013). How are spoken skills assessed in proficiency tests of general English as a Foreign Language? A preliminary survey. Servicio de Publicaciones de la Universidad de Murcia International Journal of English Studies vol. 13, (2) 53-68. Williams LS, Ganguly S, Loiseau P, Ng BF and Palacios IM (2013). The auto-inhibitory domain and ATP-independent microtubule-binding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germline. The Company of Biologists Development vol. 141, (1) 176-186. 2012
Palacios IM (2012). Nonsense-mediated mRNA decay: from mechanistic insights to impacts on human health. Oxford University Press (OUP) Briefings in Functional Genomics vol. 12, (1) 25-36. Ganguly S, Williams LS, Palacios IM and Goldstein RE (2012). Cytoplasmic streaming in Drosophila oocytes varies with kinesin activity and correlates with the microtubule cytoskeleton architecture. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 109, (38) 15109-15114. 2011
Avery P, Vicente-Crespo M, Francis D, Nashchekina O, Alonso CR and Palacios IM (2011). Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner. Cold Spring Harbor Laboratory RNA vol. 17, (4) 624-638. Vicente-Crespo M and Palacios IM (2011). Nonsense-mediated mRNA decay and development: shoot the messenger to survive? Portland Press Biochemical Society Transactions vol. 39, (1) 411-411. 2010
Vicente-Crespo M and Palacios IM (2010). Nonsense-mediated mRNA decay and development: shoot the messenger to survive? Portland Press Biochemical Society Transactions vol. 38, (6) 1500-1505. Loiseau P, Davies T, Williams LS, Mishima M and Palacios IM (2010). Drosophila PAT1 is required for Kinesin-1 to transport cargo and to maximize its motility. The Company of Biologists Journal of Cell Science vol. 123, (16) e1-e1. 2007
Meignin C, Alvarez-Garcia I, Davis I and Palacios IM (2007). The Salvador-Warts-Hippo Pathway Is Required for Epithelial Proliferation and Axis Specification in Drosophila. Elsevier Current Biology vol. 17, (21) 1871-1878. Palacios IM (2007). How does an mRNA find its way? Intracellular localisation of transcripts. Elsevier Seminars in Cell and Developmental Biology vol. 18, (2) 163-170. 2004
Palacios IM, Gatfield D, St Johnston D and Izaurralde E (2004). An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. Springer Nature Nature vol. 427, (6976) 753-757. 2003
Macchi P, Kroening S, Palacios IM, Baldassa S, Grunewald B, Ambrosino C, Goetze B, Lupas A, St. Johnston D and Kiebler M (2003). Barentsz, a New Component of the Staufen-Containing Ribonucleoprotein Particles in Mammalian Cells, Interacts with Staufen in an RNA-Dependent Manner. Society for Neuroscience Journal of Neuroscience vol. 23, (13) 5778-5788. 2002
Palacios IM and St Johnston D (2002). Kinesin light chain-independent function of the Kinesin heavy chain in cytoplasmic streaming and posterior localisation in theDrosophila oocyte. The Company of Biologists Development vol. 129, (23) 5473-5485. Benton R, Palacios IM and St Johnston D (2002). Drosophila 14-3-3/PAR-5 Is an Essential Mediator of PAR-1 Function in Axis Formation. Elsevier Developmental Cell vol. 3, (5) 659-671. Palacios IM (2002). RNA Processing: Splicing and the Cytoplasmic Localisation of mRNA. Elsevier Current Biology vol. 12, (2) r50-r52. 2001
Palacios IM and Johnston DS (2001). GETTING THE MESSAGE ACROSS: The Intracellular Localization of mRNAs in Higher Eukaryotes. Annual Reviews Annual Review of Cell and Developmental Biology vol. 17, (1) 569-614. Wagner C, Palacios I, Jaeger L, St Johnston D, Ehresmann B, Ehresmann C and Brunel C (2001). Dimerization of the 3′UTR of bicoid mRNA involves a two-step mechanism11Edited by J. Doudna. Elsevier Journal of Molecular Biology vol. 313, (3) 511-524. van Eeden FJM, Palacios IM, Petronczki M, Weston MJD and St Johnston D (2001). Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior pole. Rockefeller University Press Journal of Cell Biology vol. 154, (3) 511-524. Palacios I and Izaurralde E (2001). RNA Intracellular Transport. Encyclopedia of Life Sciences Wiley 1997
Palacios I, Hetzer M, Adam SA and Mattaj IW (1997). Nuclear import of U snRNPs requires importin β. Springer Nature The EMBO Journal vol. 16, (22) 6783-6792. Dingwall C and Palacios I (1997). Chapter 23 In Vitro Systems for the Reconstitution of snRNP and Protein Nuclear Import. Elsevier Methods in Cell Biology vol. 53, 517-543. 1996
Palacios I, Weis K, Klebe C, Mattaj IW and Dingwall C (1996). RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus. Rockefeller University Press Journal of Cell Biology vol. 133, (3) 485-494. Perales B, de la Luna S, Palacios I and Ortín J (1996). Mutational analysis identifies functional domains in the influenza A virus PB2 polymerase subunit. American Society for Microbiology Journal of Virology vol. 70, (3) 1678-1686. 1995
Boelens WC, Palacios I and Mattaj IW (1995). Nuclear retention of RNA as a mechanism for localization. RNA vol. 1, (3) 273-283. Grants
Highthroughput Light Sheet Microscopy: Imaging Across ScalesViji Draviam Sastry, Caroline Brennan, Vidya Darbari, Jose Martin Duran, Ivan Kadurin, Isabel M Palacios, Richard Pickersgill, Sarah McClelland, Tyson Sharp and Martin Knight
£386,205 MRC Medical Research Council (01-10-2022 - 31-03-2023)
A confocal microscope for multidisciplinary dynamic studies of complex biological systemsConrad Mullineaux, Caroline Brennan, Alexandre De Mendoza Soler, Viji Draviam Sastry, Maurice Elphick, Christoph Engl, Isabel M Palacios, Matteo Palma, Marina Resmini, Alexander Ruban, Peter Thorpe, Angelika Stollewerk, Jose Martin Duran, Paulo Baptista Ribeiro, Susana Alves Godinho, Richard Grose, Stephanie Kermorgant, Peter McCormick and Tyson Sharp
£390,834 BBSRC Biotechnology and Biological Sciences Research Council (01-08-2022 - 31-07-2023)