Dr Ines Sequeira
Senior Lecturer / Group Leader
Institute of Dentistry
Queen Mary University of London
Queen Mary University of London
Research
Organoids, single cell and spatial omics, skin models, oral mucosa, fibroblasts, cancer models
Interests
My research focusses on the role of fibroblasts in wound healing and regeneration, with particular interest on the outstanding scarless behaviour of the oral mucosa. To study these diverse functions we have generated oral mucosal organoids and organoids co-culture, as well as classic 3D skin and oral mucosal models. My lab has also strong expertise and nterest in single-cell and spatial omics techniques, to unravel new pathways and molecules to then test in vitro.Publications
Publications of specific relevance to Predictive <em>in vitro</em> Models2024
010 Keratin 76 expression in Thymic Epithelial Cells is Necessary for Skin T cell ToleranceGelmetti M, Tomas I, Ragazzini R, Cautela M, Campinoti S, Torre M, Watt FM, Bonfanti P, Pennington D and Sequeira I
Journal of Investigative Dermatology, Elsevier vol. 144 (12)
01-12-2024
2023
Lrig1-expression confers suppressive function to CD4+ cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axisMoon J-S, Ho C-C, Park J-H, Park K, Shin B-Y, Lee S-H, Sequeira I, Mun CH, Shin J-S, Kim J-H, Kim BS, Noh J-W, Lee E-S, Son JY, Kim Y, lee Y, Cho H, So S, Park J, Choi E, Oh J-W, Lee S-W, Morio T, Watt FM, Seong RH and Lee S-K
Nature Communications, Springer Nature vol. 14 (1)
04-09-2023
1390 Active hair growth is fuelled by conveyor-belt like differentiation of germinative layer cellsAnnusver K, Pereira D, Fernandex D, Robert B, Nicolas J, Kasper M and Sequeira I
Journal of Investigative Dermatology, Elsevier vol. 143 (5)
01-05-2023
Abstract 5629: Spatial genomics and proteomics enable multimodal analyses of oral SCC clonal heterogeneity and interactions with tumor microenvironmentKumar R, Ibrahim R, Cheikh BB, Bailey E, Cottom H, Braubach O, Graham T, Wang J and Sequeira I
Cancer Research, American Association For Cancer Research (Aacr) vol. 83 (7_Supplement), 5629-5629.
04-04-2023
2022
603 Dissecting the role of fibroblasts in homeostasis and wound healing of the oral mucosaPereira DG, Kirk T, Mavros A, Rognoni E, O’Toole EA, Kasper M and Sequeira I
Journal of Investigative Dermatology, Elsevier vol. 142 (12)
01-12-2022
Fat Graft Retention: Adipose Tissue, Adipose-Derived Stem Cells, and AgingTrotzier C, Sequeira I, Auxenfans C and Mojallal AA
Plastic & Reconstructive Surgery, Wolters Kluwer vol. 151 (3), 420e-431e.
22-11-2022
A Roadmap for the Human Oral and Craniofacial Cell AtlasCaetano AJ, Caetano A, Sharpe P, Volponi AA, Yianni V, Bush M, McKay LK, Wallet S, Shazib MA, Kimple A, Byrd KM, Easter Q, Weaver T, Sequeira I, Kumar R, Pereira D, Macken J, Fortune F, Efremova M, Teichmann S, Kretzschmar K, Todres E, Boffelli D, Hagood JS, Klein O, Boucher R, Lwin S, Pranzatelli T, Beachy P and Lu WJ
Journal of Dental Research, Sage Publications vol. 101 (11), 1274-1288.
26-09-2022
Assessing the Role of Carbonyl Adducts, Particularly Malondialdehyde Adducts, in the Development of Dermis Yellowing Occurring during Skin PhotoagingZucchi H, Pageon H, Asselineau D, Ghibaudo M, Sequeira I and Girardeau-Hubert S
Life, Mdpi vol. 12 (3)
10-03-2022
2021
Comparison of Whiskbroom and Pushbroom darkfield elastic light scattering spectroscopic imaging for head and neck cancer identification in a mouse modelBassler MC, Stefanakis M, Sequeira I, Ostertag E, Wagner A, Bartsch JW, Roeßler M, Mandic R, Reddmann EF, Lorenz A, Rebner K and Brecht M
Analytical and Bioanalytical Chemistry, Springer Nature vol. 413 (30), 7363-7383.
19-11-2021
A Scarless Healing Tale: Comparing Homeostasis and Wound Healing of Oral Mucosa With Skin and OesophagusPereira D and Sequeira I
Frontiers in Cell and Developmental Biology, Frontiers vol. 9
26-07-2021
SARS-CoV-2 infection of the oral cavity and salivaHuang N, Pérez P, Kato T, Mikami Y, Okuda K, Gilmore RC, Conde CD, Gasmi B, Stein S, Beach M, Pelayo E, Maldonado JO, Lafont BA, Jang S-I, Nasir N, Padilla RJ, Murrah VA, Maile R, Lovell W, Wallet SM, Bowman NM, Meinig SL, Wolfgang MC, Choudhury SN, Novotny M, Aevermann BD, Scheuermann RH, Cannon G, Anderson CW and Lee RE
Nature Medicine, Springer Nature vol. 27 (5), 892-903.
25-03-2021
2020
Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecologySequeira I, Rashid M, Tomás IM, Williams MJ, Graham TA, Adams DJ, Vigilante A and Watt FM
Nature Communications, Springer Nature vol. 11 (1)
09-11-2020
The Molecular Anatomy of Mouse Skin during Hair Growth and RestJoost S, Annusver K, Jacob T, Sun X, Dalessandri T, Sivan U, Sequeira I, Sandberg R and Kasper M
Cell Stem Cell, Elsevier Bv vol. 26 (3), 441-457.e7.
01-03-2020
2019
Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological StressByrd KM, Piehl NC, Patel JH, Huh WJ, Sequeira I, Lough KJ, Wagner BL, Marangoni P, Watt FM, Klein OD, Coffey RJ and Williams SE
Cell Stem Cell, Elsevier Bv vol. 25 (6), 814-829.e6.
05-12-2019
233 Epidermal differentiation and proliferation heterogeneity in skin color typesGirardeau-Hubert S, Deneuville C, Pageon H, Abed K, Tacheau C, Cavusoglu N, donovan R, Bernard D, Asselineau D and Sequeira I
Journal of Investigative Dermatology, Elsevier vol. 139 (9)
01-09-2019
The role of keratins in modulating carcinogenesis via communication with cells of the immune systemSequeira I and Watt FM
Cell Stress, Shared Science Publishers Og vol. 3 (4), 136-138.
23-03-2019
2018
Immunomodulatory role of Keratin 76 in oral and gastric cancerSequeira I, Neves JF, Carrero D, Peng Q, Palasz N, Liakath-Ali K, Lord GM, Morgan PR, Lombardi G and Watt FM
Nature Communications, Springer Science and Business Media Llc vol. 9 (1)
24-08-2018
Myosin 10 is involved in murine pigmentationLiakath‐Ali K, Vancollie VE, Sequeira I, Lelliott CJ and Watt FM
Experimental Dermatology, Wiley vol. 28 (4), 391-394.
24-04-2018
An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasisLiakath-Ali K, Mills EW, Sequeira I, Lichtenberger BM, Pisco AO, Sipilä KH, Mishra A, Yoshikawa H, Wu CC-C, Ly T, Lamond AI, Adham IM, Green R and Watt FM
Nature, Springer Science and Business Media Llc vol. 556 (7701), 376-380.
01-04-2018
2017
Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and GrowthTelerman SB, Rognoni E, Sequeira I, Pisco AO, Lichtenberger BM, Culley OJ, Viswanathan P, Driskell RR and Watt FM
Journal of Investigative Dermatology, Elsevier Bv vol. 137 (11), 2270-2281.
23-09-2017
2016
Macrophage Infiltration and Alternative Activation during Wound Healing Promote MEK1-Induced Skin CarcinogenesisWeber C, Telerman SB, Reimer AS, Sequeira I, Liakath-Ali K, Arwert EN and Watt FM
Cancer Research, American Association For Cancer Research (Aacr) vol. 76 (4), 805-817.
14-02-2016
2012
Redefining the structure of the hair follicle by 3D clonal analysisSequeira I and Nicolas J-F
Development, The Company of Biologists vol. 139 (20), 3741-3751.
18-09-2012
Myogenic waves and myogenic programs during Xenopus embryonic myogenesisDella Gaspera B, Armand A, Sequeira I, Chesneau A, Mazabraud A, Lécolle S, Charbonnier F and Chanoine C
Developmental Dynamics, Wiley vol. 241 (5), 995-1007.
16-04-2012
2010
Hair follicle renewal: authentic morphogenesis that depends on a complex progression of stem cell lineagesLegué E, Sequeira I and Nicolas J-F
Development, The Company of Biologists vol. 137 (4), 569-577.
28-01-2010
2009
The Xenopus MEF2 gene family: Evidence of a role for XMEF2C in larval tendon developmentdella Gaspera B, Armand A-S, Sequeira I, Lecolle S, Gallien CL, Charbonnier F and Chanoine C
Developmental Biology, Elsevier vol. 328 (2), 392-402.
05-02-2009
2005
Spatio‐temporal expression of MRF4 transcripts and protein during Xenopus laevis embryogenesisDella Gaspera B, Sequeira I, Charbonnier F, Becker C, Shi D and Chanoine C
Developmental Dynamics, Wiley vol. 235 (2), 524-529.
28-10-2005