Dr Jianmin Chen
Lecturer in Inflammation and Cardiovascular Medicine; Versus Arthritis Career Development Fellow
The William Harvey Research Institute
Queen Mary University of London
Queen Mary University of London
Research
Cardiomyopathy, HFpEF, Rheumatoid arthritis, Immune cells, Metabolism, Inflammation
Interests
I am interested in modeling the impact of arthritic synovial inflammation on the heart using interconnected organ-on-a-chip systems. Microfluidics which are introduced through an ibidi pump-based system can connect the two organ models, enabling the study of complex multicellular interactions driving cardiac fibrosis. This model will provide valuable insights into disease mechanisms and serve as a platform for screening and evaluating new therapeutics for both arthritis treatment and cardiac protection.Publications
2025
Formyl-peptide receptor type 2 activation mitigates heart and lung damage in inflammatory arthritisEmbo Molecular Medicine, Springer Science and Business Media Llc vol. 17 (5), 1153-1183.
03-04-2025
2024
Pro-resolving lipid mediators and therapeutic innovations in resolution of inflammationPeh HY, Chen J
Pharmacology & Therapeutics, Elsevier vol. 265
18-11-2024
Editorial: Cardiometabolic diseases and inflammatory responsesSuffee N, Le Goff W, Chen J
Frontiers in Immunology, Frontiers vol. 15
01-03-2024
2023
The Annexin-A1 mimetic RTP-026 promotes acute cardioprotection through modulation of immune cell activationChen J, Oggero S, Cecconello C, Dalli J, Hayat H, Hjiej Andaloussi A, Sanni S, Jonassen TEN et al.
Pharmacological Research, Elsevier Bv vol. 198, 107005-107005.
01-12-2023
Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac DysfunctionChen J, Austin-Williams S, O'Riordan CE, Claria-Ribas P, Sugimoto MA, Norling LV, Thiemermann C, Perretti M
Journal of Innate Immunity, S. Karger Ag vol. 15 (1), 548-561.
01-01-2023
2022
Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue diseaseCosta VV, Sugimoto MA, Hubner J, Bonilha CS, Queiroz-Junior CM, Gonçalves-Pereira MH, Chen J, Gobbetti T et al.
Elife, Elife Sciences Publications, Ltd vol. 11
16-03-2022
20‐hydroxyeicosatetraenoic acid (20‐HETE) is a pivotal endogenous ligand for TRPV1‐mediated neurogenic inflammation in the skinHamers A, Primus CP, Whitear C, Kumar NA, Masucci M, Montalvo Moreira SA, Rathod K, Chen J et al.
British Journal of Pharmacology, Wiley vol. 179 (7), 1450-1469.
14-02-2022
2021
Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritisChen J, Norling LV, Garrido Mesa J, Silva MDP, Burton SE, Reutelingsperger C, Perretti M, Cooper D
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 118 (38)
15-09-2021
Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A4 Mimetics (QNX-sLXms)de Gaetano M, Tighe C, Gahan K, Zanetti A, Chen J, Newson J, Cacace A, Marai M et al.
Journal of Medicinal Chemistry, American Chemical Society (Acs) vol. 64 (13), 9193-9216.
17-06-2021
2020
RvE1 Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction and Enhances Bacterial ClearanceChen J, Purvis GSD, Collotta D, Al Zoubi S, Sugimoto MA, Cacace A, Martin L, Colas RA et al.
Frontiers in Immunology, Frontiers Media Sa vol. 11
02-09-2020
Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemiaAziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S et al.
Journal of Molecular Medicine, Springer Science and Business Media Llc
06-07-2020
Immunohistochemistry of Kidney a-SMA, Collagen 1, and Collagen 3, in A Novel Mouse Model of Reno-cardiac Syndrome.Kieswich JE, Chen J, Alliouachene S, Caton PW, McCafferty K, Thiemermann C, Yaqoob MM
Bio-Protocol, Bio-Protocol vol. 10 (18)
01-01-2020
2019
Long residence time adenosine A1 receptor agonists produce sustained wash-resistant antilipolytic effect in rat adipocytesYun Y, Chen J, Liu R, Chen W, Liu C, Wang R, Hou Z, Yu Z et al.
Biochemical Pharmacology, Elsevier vol. 164, 45-52.
21-03-2019
Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms)de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E et al.
European Journal of Medicinal Chemistry, Elsevier Bv vol. 162, 80-108.
01-01-2019
2018
Linagliptin Attenuates the Cardiac Dysfunction Associated With Experimental Sepsis in Mice With Pre-existing Type 2 Diabetes by Inhibiting NF-κBAl Zoubi S, Chen J, Murphy C, Martin L, Chiazza F, Collotta D, Yaqoob MM, Collino M et al.
Frontiers in Immunology, Frontiers vol. 9
18-12-2018
A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strainKieswich JE, Chen J, Alliouachene S, Caton PW, McCafferty K, Thiemermann C, Yaqoob MM
Bmc Nephrology, Springer Nature vol. 19 (1)
01-12-2018
The Antimalarial Drug Artesunate Attenuates Cardiac Injury in A Rodent Model of Myocardial Infarction.Khan AI, Kapoor A, Chen J, Martin L, Rogazzo M, Mercier T, Decosterd L, Collino M et al.
Shock vol. 49 (6), 675-681.
01-06-2018
Endogenously generated arachidonate‐derived ligands for TRPV1 induce cardiac protection in sepsisChen J, Hamers AJP, Finsterbusch M, Massimo G, Zafar M, Corder R, Colas RA, Dalli J et al.
The Faseb Journal, Wiley vol. 32 (7), 3816-3831.
20-02-2018
2017
Inhibition of IκB Kinase at 24 Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis.J Am Heart Assoc vol. 6 (7)
03-07-2017
The β-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men.Martin L, Gombert A, Chen J, Liebens J, Verleger J, Kalder J, Marx G, Jacobs M et al.
Front Immunol, Frontiers Media vol. 8, 681-681.
12-06-2017
ROLE OF THE beta-D-ENDOGLUCURONIDASE HEPARANASE IN SEPTIC CARDIOMYOPATHYMartin L, Chen J, Zechendorf E, Chiazza F, Oggero S, Collino M, Marx G, Schuerholz T et al.
European Shock Society.
01-06-2017
2016
ACTIVATION OF TRPV1 BY 12(S)-HPETE AND 20-HETE RELEASES CGRP AND PROTECTS THE HEART AGAINST THE CARDIAC DYSFUNCTION CAUSED BY LPSChen J, Hamers AJP, Finsterbusch M, Thiemermann C, Ahluwalia A
Exp Biology 2016.
01-10-2016
THE SYNTHETIC ANTIMICROBIAL PEPTIDE 19-2.5 ATTENUATES SEPTIC CARDIOMYOPATHY IN A MURINE MODEL OF POLYMICROBIAL SEPSISMartin LB, Zechendorf E, Chen J, Brandenburg K, Marx G, Thiemermann C, Schuerholz T
Japanese Shock Society.
01-10-2016
Selenium and Niacin for Sepsis TherapyChen J, Thiemermann C
Critical Care Medicine, Wolters Kluwer vol. 44 (6), 1256-1257.
01-06-2016
IκB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKDJournal of The American Society of Nephrology, Ovid Technologies (Wolters Kluwer Health) vol. 28 (1), 94-105.
06-05-2016
Activation of TRPV1 by 12(s)-HpETE and 20-HETE Releases CGRP and Protects the Heart Against the Cardiac Dysfunction Caused by LPSChen J, Hamers AJP, Finsterbusch M, Thiemermann C, Ahluwalia A
Exp Biology (FASEB) 2016.
01-04-2016
The association of depressed angiogenic factors with reduced capillary density in the Rhesus monkey model of myocardial ischemiaZhang W, Zhao X, Xiao Y, Chen J, Han P, Zhang J, Fu H, Kang YJ
Metallomics, Oxford University Press (Oup) vol. 8 (7), 654-662.
01-01-2016
2015
THE CARDIAC DYSFUNCTION CAUSED BY SEPSIS IN ANIMALS WITH CHRONIC KIDNEY DISEASE IS ATTENUATED BY INHIBITING IκB KINASEChen J, Kieswich J, Chiazza F, Gobbetti T, Patel NS, Perretti M, Collino M, Yaqoob MM et al.
01-01-2015
2014
Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsisGobbetti T, Coldewey SM, Chen J, McArthur S, le Faouder P, Cenac N, Flower RJ, Thiemermann C et al.
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 111 (52), 18685-18690.
15-12-2014
Gender Dimorphism of the Cardiac Dysfunction in Murine Sepsis: Signalling Mechanisms and Age-DependencyChen J, Chiazza F, Collino M, Patel NSA, Coldewey SM, Thiemermann C
Plos One, Public Library of Science (Plos) vol. 9 (6)
19-06-2014
GENDER DIMORPHISM OF THE CARDIAC DYSFUNCTION IN SEPSISChen J, Chiazza F, Collino M, Coldewey SM, Patel NS, Thiemermann C
01-01-2014
PRE-EXISTING CHRONIC KIDNEY DISEASE WORSENS MYOCARDIAL DYSFUNCTION CAUSED BY SEPSIS IN MICEChen J, Kieswich J, Yaqoob MM, Thiemermann C
01-01-2014
2013
Decreases in Electrocardiographic R-Wave Amplitude and QT Interval Predict Myocardial Ischemic Infarction in Rhesus Monkeys with Left Anterior Descending Artery LigationSun X, Cai J, Fan X, Han P, Xie Y, Chen J, Xiao Y, Kang YJ
Plos One, Public Library of Science (Plos) vol. 8 (8)
13-08-2013
EFFECTS OF THE PPAR-β/δ AGONIST GW0742 ON RENAL INFLAMMATION AND KIDNEY TISSUE INJURY DURING RESUSCITATED PORCINE SEPTIC SHOCKHafner S, Wepler M, McCook O, Scheuerle A, Wagner F, Matallo J, Chen J, Calzia E et al.
01-01-2013
2012
Immunohistochemical detection of differentially localized up-regulation of lysyl oxidase and down-regulation of matrix metalloproteinase-1 in rhesus monkey model of chronic myocardial infarctionXie Y, Chen J, Han P, Yang P, Hou J, Kang YJ
Experimental Biology and Medicine, Frontiers vol. 237 (7), 853-859.
01-07-2012
Treatment with Annexin A1 attenuates the development of diabetic nephropathy and cardiomyopathy, in murine type 1 diabetes, through restoration of AKT signalling.Diabetologia, Springer Verlag
Inorganic nitrate attenuates cardiac dysfunction: role for xanthine oxidoreductase and nitric oxideBritish Journal of Pharmacology, Wiley
Grants
Grants of specific relevance to Predictive in vitro Models
Cardiomyopathy in Rheumatoid ArthritisNay Aung, Mauro Perretti, Jianmin Chen and Felice Rivellese
£302,522 Barts and the London Charity
01-10-2025 - 03-10-2028
COacT PhD Studentship_Band A 25/26 - Heart-joint On A ChipLucy Norling, Thomas Iskratsch and Jianmin Chen
£171,868 SynAct Pharma ApS, Denmark
01-10-2025 - 30-09-2029
PHEast: Phenylalanine promotes cardiac dysfunction by driving hyperphagiaGabor Czibik and Jianmin Chen
£320,385 Barts and the London Charity
01-01-2025 - 31-12-2028
Unravelling the cardiovascular implications of rheumatoid arthritis: A comprehensive investigation using cardiac MRI and novel biomarkersJianmin Chen
£5,000 WHRF William Harvey Research Foundation
14-10-2024 - 13-08-2027
Blood analysis protocol: Efficacy of RTP026 in MI patientsMauro Perretti, Jianmin Chen and Sharmilee Gnanapavan
£261,605 William Harvey Research Limited
01-09-2024 - 28-02-2027
LPS-induced endotoxaemia/sepsis syndromeJianmin Chen
£13,904 William Harvey Research Limited
01-08-2024 - 31-10-2026
Targeting heart failure with preserved ejection fraction in settings of arthritisJianmin Chen and Federica Marelli-Berg
£121,068 Heart Research UK
01-01-2023 - 30-06-2026
Modelling cardiomyopathy in inflammatory arthritis to define mechanisms and guide therapeutic strategiesJianmin Chen
£469,692 AR-UK Versus Arthritis
18-08-2022 - 17-07-2027
Joint Attack: Arthritis and metabolic syndrome in the HFpEF comorbidity networkJianmin Chen and Dianne Cooper
£75,000 Barts and the London Charity
18-04-2024 - 31-05-2025
Hypertension and rheumatoid arthritis as co-morbidities in heart failureDianne Cooper and Jianmin Chen
£49,919 Barts and the London Charity
17-10-2022 - 31-01-2024