Dr Jianmin Chen
Lecturer in Inflammation and Cardiovascular Medicine; Versus Arthritis Career Development Fellow
The William Harvey Research Institute
Queen Mary University of London
Queen Mary University of London
Research
Cardiomyopathy, HFpEF, Rheumatoid arthritis, Immune cells, Metabolism, Inflammation
Interests
I am interested to study the switching of phenotypes and alterations in phagocytosis activity of macrophages upon pharmaceutical treatments in vitro. This assay can be conducted with biogel-elicited macrophages or bone marrow-derived macrophages. Phenotypes and phagocytosis activity of macrophages can be determined by flow cytometry. I have also developed techniques to look at mitochondrial mass and potential from isolated primary cardiomyocytes, immune cells, cardiac fibroblasts and endothelial cells using flow cytometry.Publications
2023
Chen J, Oggero S, Cecconello C, Dalli J, Hayat H, Hjiej Andaloussi A, Sanni S, Jonassen TE and Perretti M (2023). The Annexin-A1 mimetic RTP-026 promotes acute cardioprotection through modulation of immune cell activation. Elsevier Pharmacological Research vol. 198, Chen J, Austin-Williams S, O'Riordan CE, Claria-Ribas P, Sugimoto MA, Norling LV, Thiemermann C and Perretti M (2023). Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction. Karger Publishers Journal of Innate Immunity vol. 15, (1) 548-561. 2022
Costa VV, Sugimoto MA, Hubner J, Bonilha CS, Queiroz-Junior CM, Gonçalves-Pereira MH, Chen J, Gobbetti T, Rodrigues GOL, Bambirra JL, Passos IB, Lopes CEM, Moreira TP, Bonjour K, Melo RC, Oliveira MA, Andrade MVM, Sousa LP, Souza DG, da Costa Santiago H, Perretti M and Teixeira MM (2022). Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease. eLife eLife vol. 11, Hamers A, Primus CP, Whitear C, Kumar NA, Masucci M, Moreira SAM, Rathod K, Chen J, Bubb K, Colas R, Khambata RS, Dalli J and Ahluwalia A (2022). 20‐hydroxyeicosatetraenoic acid (20‐HETE) is a pivotal endogenous ligand for TRPV1‐mediated neurogenic inflammation in the skin. Wiley British Journal of Pharmacology vol. 179, (7) 1450-1469. 2021
Gee LC, Massimo G, Lau C, Primus C, Fernandes D, Chen J, Rathod KS, Hamers AJP, Filomena F, Nuredini G, Ibrahim AS, Khambata RS, Gupta AK, Moon JC, Kapil V and Ahluwalia A (2021). Inorganic nitrate attenuates cardiac dysfunction: roles for xanthine oxidoreductase and nitric oxide. Wiley British Journal of Pharmacology vol. 179, (20) 4757-4777. Chen J, Norling LV, Mesa JG, Silva MDP, Burton SE, Reutelingsperger C, Perretti M and Cooper D (2021). Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 118, (38) de Gaetano M, Tighe C, Gahan K, Zanetti A, Chen J, Newson J, Cacace A, Marai M, Gaffney A, Brennan E, Kantharidis P, Cooper ME, Leroy X, Perretti M, Gilroy D, Godson C and Guiry PJ (2021). Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A4 Mimetics (QNX-sLXms). American Chemical Society (ACS) Journal of Medicinal Chemistry vol. 64, (13) 9193-9216. 2020
Chen J, Purvis GSD, Collotta D, Zoubi SA, Sugimoto MA, Cacace A, Martin L, Colas RA, Collino M, Dalli J and Thiemermann C (2020). RvE1 Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction and Enhances Bacterial Clearance. Frontiers Media Frontiers in Immunology vol. 11, 2080-2080. Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S, Hobbs AJ, Thiemermann C and Tinker A (2020). Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia. Springer Science and Business Media LLC Journal of Molecular Medicine Kieswich JE, Chen J, Alliouachene S, Caton PW, McCafferty K, Thiemermann C and Yaqoob MM (2020). Immunohistochemistry of Kidney a-SMA, Collagen 1, and Collagen 3, in A Novel Mouse Model of Reno-cardiac Syndrome. Bio-Protocol Bio-protocol vol. 10, (18) 2019
Yun Y, Chen J, Liu R, Chen W, Liu C, Wang R, Hou Z, Yu Z, Sun Y, IJzerman AP, Heitman LH, Yin X and Guo D (2019). Long residence time adenosine A1 receptor agonists produce sustained wash-resistant antilipolytic effect in rat adipocytes. Elsevier Biochemical Pharmacology vol. 164, 45-52. 2018
Al Zoubi S, Chen J, Murphy C, Martin L, Chiazza F, Collotta D, Yaqoob MM, Collino M and Thiemermann C (2018). Linagliptin Attenuates the Cardiac Dysfunction Associated With Experimental Sepsis in Mice With Pre-existing Type 2 Diabetes by Inhibiting NF-κB. Frontiers Frontiers in Immunology vol. 9, Kieswich JE, Chen J, Alliouachene S, Caton PW, McCafferty K, Thiemermann C and Yaqoob MM (2018). A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain. Springer Nature BMC Nephrology vol. 19, (1) de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E, Maingot C, McLoughlin A, Brennan E, Leroy X, Loscher CE, Fallon P, Perretti M, Godson C and Guiry PJ (2018). Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms). Elsevier European Journal of Medicinal Chemistry vol. 162, 80-108. Chen J, Hamers AJP, Finsterbusch M, Massimo G, Zafar M, Corder R, Colas RA, Dalli J, Thiemermann C and Ahluwalia A (2018). Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis. FASEB J fj201701303-fj201701303. Khan AI, Kapoor A, Chen J, Martin L, Rogazzo M, Mercier T, Decosterd L, Collino M and Thiemermann C (2018). The Antimalarial Drug Artesunate Attenuates Cardiac Injury in A Rodent Model of Myocardial Infarction. Shock vol. 49, (6) 675-681. 2017
Purvis GSD, Chiazza F, Chen J, Loiola RA, Martin L, Fountoulakis N, Gnudi L, Collino M, Thiemermann C and Solito E (2017). Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes. Springer Verlag Diabetologia Johnson FL, Patel NSA, Purvis GSD, Chiazza F, Chen J, Sordi R, Hache G, Merezhko VV, Collino M, Yaqoob MM and Thiemermann C (2017). Inhibition of IκB Kinase at 24 Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis. J Am Heart Assoc vol. 6, (7) Martin L, Gombert A, Chen J, Liebens J, Verleger J, Kalder J, Marx G, Jacobs M, Thiemermann C and Schuerholz T (2017). The β-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men. Frontiers Media Front Immunol vol. 8, 681-681. 2016
Chen J and Thiemermann C (2016). Selenium and Niacin for Sepsis Therapy. Wolters Kluwer Critical Care Medicine vol. 44, (6) 1256-1257. Chen J, Kieswich J, Chiazza F, Moyes A, Gobbetti T, Purvis G, Salvatori D, Patel N, Perretti M, Hobbs A, Collino M, Yaqoob M and THIEMERMANN C (2016). IkB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD. American Society of Nephrology Journal of the American Society of Nephrology Zhang W, Zhao X, Xiao Y, Chen J, Han P, Zhang J, Fu H and Kang YJ (2016). The association of depressed angiogenic factors with reduced capillary density in the Rhesus monkey model of myocardial ischemia. Oxford University Press (OUP) Metallomics vol. 8, (7) 654-662. 2014
Gobbetti T, Coldewey SM, Chen J, McArthur S, le Faouder P, Cenac N, Flower RJ, Thiemermann C and Perretti M (2014). Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 111, (52) 18685-18690. Chen J, Chiazza F, Collino M, Patel NSA, Coldewey SM and Thiemermann C (2014). Gender Dimorphism of the Cardiac Dysfunction in Murine Sepsis: Signalling Mechanisms and Age-Dependency. Public Library of Science (PLoS) PLOS ONE vol. 9, (6) 2013
Sun X, Cai J, Fan X, Han P, Xie Y, Chen J, Xiao Y and Kang YJ (2013). Decreases in Electrocardiographic R-Wave Amplitude and QT Interval Predict Myocardial Ischemic Infarction in Rhesus Monkeys with Left Anterior Descending Artery Ligation. Public Library of Science (PLoS) PLOS ONE vol. 8, (8) 2012
Xie Y, Chen J, Han P, Yang P, Hou J and Kang YJ (2012). Immunohistochemical detection of differentially localized up-regulation of lysyl oxidase and down-regulation of matrix metalloproteinase-1 in rhesus monkey model of chronic myocardial infarction. Frontiers Experimental Biology and Medicine vol. 237, (7) 853-859. Grants
Blood analysis protocol: Efficacy of RTP026 in MI patientsMauro Perretti, Jianmin Chen and Sharmilee Gnanapavan
£261,605 WHRL William Harvey Research Limited (01-09-2024 - 28-02-2027)