Prof Jesmond Dalli
Professor in Molecular Pharmacology
Research
Tissue repair and regeneration, Myelopoesis, resolution mechanisms, GPCR biology, innate immunity, lipid mediators
Interests
My research interests are in understanding the biology of a novel class of essential fatty acid derived molecules termed as specilized pro-resolving mediators in regulating innate immunity and reparative mechanisms. We are developing and using new in vitro organ-chip models, including bone marrow and joint models, for understanding disease and testing potential therapeutics.Publications
Publications of specific relevance to Predictive in vitro Models2024
Dooley M, Saliani A and Dalli J (2024). Development and Validation of Methodologies for the Identification of Specialized Pro-Resolving Lipid Mediators and Classic Eicosanoids in Biological Matrices. American Chemical Society (ACS) Journal of The American Society for Mass Spectrometry vol. 35, (10) 2331-2343. Gomez EA, De Matteis R, Udomjarumanee P, Team GAHR, Akhtar S, Anwar M, Arciero E, Asgar O, Ashraf S, Bidi S, Breen G, Broster J, Chaudhary S, Chung R, Clinch M, Collier D, Colligan G, Curtis CJ, Deloukas P, Durham C, Durrani F, Eto F, Finer S, Gafton J, Garcia ACA, Griffiths C, Harvey J, van Heel DA, Heng T and Hodgson S (2024). An LGR6 frameshift variant abrogates receptor expression on select leukocyte subsets and is associated with viral infections. American Society of Hematology Blood vol. 144, (4) 420-434. Leuti A, Fava M, Forte G, Pellegrini N, Oddi S, Scipioni L, Gomez EA, Dalli J and Maccarrone M (2024). The endocannabinoid anandamide activates pro‐resolving pathways in human primary macrophages by engaging both CB2 and GPR18 receptors. Wiley The FASEB Journal vol. 38, (10) Rodrigues-Diez R, Ballesteros-Martinez C, Moreno-Carriles RM, Nistal F, Díaz Del Campo LS, Cachofeiro V, Dalli J, García-Redondo AB, Redondo JM, Salaices M and Briones AM (2024). Resolvin D2 prevents vascular remodeling, hypercontractility and endothelial dysfunction in obese hypertensive mice through modulation of vascular and proinflammatory factors. Elsevier Biomedicine & Pharmacotherapy vol. 174, Walker ME, De Matteis R, Perretti M and Dalli J (2024). Resolvin T4 enhances macrophage cholesterol efflux to reduce vascular disease. Springer Nature Nature Communications vol. 15, (1) Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR, Schmidt B, Dalli J, Greene ER, Gus-Brautbar Y, Piwowarski J, Mammoto T, Zurakowski D, Perretti M, Sukhatme VP, Kaipainen A, Kieran MW, Huang S and Panigrahy D (2024). Addendum: Resolvins suppress tumor growth and enhance cancer therapy. Rockefeller University Press Journal of Experimental Medicine vol. 221, (3) Aguirre GA, Goulart MR, Bank BPT, Dalli J and Kocher HM (2024). Corrigendum: Arachidonate 15-lipoxygenase-mediated production of Resolvin D5n-3 DPA abrogates pancreatic stellate cell-induced cancer cell invasion. Frontiers Frontiers in Immunology vol. 15, 2023
Koenis DS, de Matteis R, Rajeeve V, Cutillas P and Dalli J (2023). Efferocyte‐Derived MCTRs Metabolically Prime Macrophages for Continual Efferocytosis via Rac1‐Mediated Activation of Glycolysis. Wiley Advanced Science vol. 11, (7) Chen J, Oggero S, Cecconello C, Dalli J, Hayat H, Hjiej Andaloussi A, Sanni S, Jonassen TE and Perretti M (2023). The Annexin-A1 mimetic RTP-026 promotes acute cardioprotection through modulation of immune cell activation. Elsevier Pharmacological Research vol. 198, Aguirre GA, Goulart MR, Bank BPT, Dalli J and Kocher HM (2023). Arachidonate 15-lipoxygenase-mediated production of Resolvin D5n-3 DPA abrogates pancreatic stellate cell-induced cancer cell invasion. Frontiers Frontiers in Immunology vol. 14, Dalli J and Gomez EA (2023). Reply to: Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples. Springer Nature Nature Communications vol. 14, (1) Ervik K, Reinertsen AF, Koenis DS, Dalli J and Hansen TV (2023). Stereoselective Synthesis, Pro-resolution, and Anti-inflammatory Actions of RvD5n‑3 DPA. American Chemical Society (ACS) Journal of Natural Products vol. 86, (11) 2546-2553. Ramirez JL, de Almeida Oliveira G, Calvo E, Dalli J, Colas RA, Serhan CN, Ribeiro JM and Barillas-Mury C (2023). Author Correction: A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae. Springer Nature Nature Communications vol. 14, (1) Laiglesia LM, Escoté X, Sáinz N, Felix-Soriano E, Santamaría E, Collantes M, Fernández-Galilea M, Colón-Mesa I, Martínez-Fernández L, Quesada-López T, Quesada-Vázquez S, Rodríguez-Ortigosa C, Arbones-Mainar JM, Valverde ÁM, Martínez JA, Dalli J, Herrero L, Lorente-Cebrián S, Villarroya F and Moreno-Aliaga MJ (2023). Maresin 1 activates brown adipose tissue and promotes browning of white adipose tissue in mice. Elsevier Molecular Metabolism vol. 74, Mai NTH, Dobbs N, Phu NH, Colas RA, Thao LTP, Thuong NTT, Nghia HDT, Hanh NHH, Hang NT, Heemskerk AD, Day JN, Ly L, Thu DDA, Merson L, Kestelyn E, Wolbers M, Geskus R, Summers D, Chau NVV, Dalli J and Thwaites GE (2023). Correction: A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults. eLife eLife vol. 12, Dalli J, Kitch D, O'Brien MP, Hunt PW, Funderburg N, Moisi D, Gupta A, Brown TT, Tien PC, Aberg JA and Shivakoti R (2023). Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin intervention. Elsevier EBioMedicine vol. 89, Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN and Perretti M (2023). Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. American Society for Clinical Investigation JCI Insight vol. 8, (3) Rathod KS, Kapil V, Velmurugan S, Khambata RS, Siddique U, Khan S, Van Eijl S, Gee LC, Bansal J, Pitrola K, Shaw C, D'Acquisto F, Colas RA, Marelli-Berg F, Dalli J and Ahluwalia A (2023). Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans. American Society for Clinical Investigation Journal of Clinical Investigation vol. 133, (2) 2022
Flak MB, Koenis DS, Gonzalez-Nunez M, Chopo-Pizarro A and Dalli J (2022). Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation. Elsevier Biochemical Pharmacology vol. 207, del Campo LSD, García-Redondo AB, Rodríguez C, Zaragoza C, Duro-Sánchez S, Palmas F, de Benito-Bueno A, Socuéllamos PG, Peraza DA, Rodrigues-Díez R, Valenzuela C, Dalli J, Salaices M and Briones AM (2022). Resolvin D2 Attenuates Cardiovascular Damage in Angiotensin II-Induced Hypertension. Wolters Kluwer Hypertension vol. 80, (1) 84-96. Silva RA, Domingos R, Trujillo M, Filho A, Oliveira C, Baldini R, Dalli J and Netto L (2022). LsfA, a 1-Cys Peroxiredoxin involved with Pseudomonas aeruginosa virulence: Structure, biochemical activity, and its influence in inflammation/resolution. Elsevier Free Radical Biology and Medicine vol. 192, Flak MB, Colas RA, Muñoz-Atienza E, Curtis MA, Dalli J and Pitzalis C (2022). Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis. American Society for Clinical Investigation JCI Insight vol. 7, (20) Perretti M and Dalli J (2022). Resolution Pharmacology: Focus on Pro-Resolving Annexin A1 and Lipid Mediators for Therapeutic Innovation in Inflammation. Annual Reviews The Annual Review of Pharmacology and Toxicology vol. 63, (1) 449-469. Caravaca AS, Gallina AL, Tarnawski L, Shavva VS, Colas RA, Dalli J, Malin SG, Hult H, Arnardottir H and Olofsson PS (2022). Vagus nerve stimulation promotes resolution of inflammation by a mechanism that involves Alox15 and requires the α7nAChR subunit. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 119, (22) Sips M, Gerlo S, De Clercq L, Gomez EA, Colas RA, Dalli J and Vandekerckhove L (2022). Distinct immune profiles of HIV‐infected subjects are linked to specific lipid mediator signature. Wiley Immunity Inflammation and Disease vol. 10, (6) Pistorius K, Ly L, Souza PR, Gomez EA, Koenis DS, Rodriguez AR, Foster J, Sosabowski J, Hopkinson M, Rajeeve V, Spur BW, Pitsillides A, Pitzalis C and Dalli J (2022). MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis. Elsevier EBioMedicine vol. 79, Dyall SC, Balas L, Bazan NG, Brenna JT, Chiang N, da Costa Souza F, Dalli J, Durand T, Galano J-M, Lein PJ, Serhan CN and Taha AY (2022). Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions. Elsevier Progress in Lipid Research vol. 86, Dalli J, Gomez EA and Jouvene CC (2022). Utility of the Specialized Pro-Resolving Mediators as Diagnostic and Prognostic Biomarkers in Disease. MDPI Biomolecules vol. 12, (3) Mikroulis A, Ledri M, Ruffolo G, Palma E, Sperk G, Dalli J, Vezzani A and Kokaia M (2022). Lipid mediator n‐3 docosapentaenoic acid‐derived protectin D1 enhances synaptic inhibition of hippocampal principal neurons by interaction with a G‐protein‐coupled receptor. Wiley The FASEB Journal vol. 36, (3) Hamers A, Primus CP, Whitear C, Kumar NA, Masucci M, Moreira SAM, Rathod K, Chen J, Bubb K, Colas R, Khambata RS, Dalli J and Ahluwalia A (2022). 20‐hydroxyeicosatetraenoic acid (20‐HETE) is a pivotal endogenous ligand for TRPV1‐mediated neurogenic inflammation in the skin. Wiley British Journal of Pharmacology vol. 179, (7) 1450-1469. De Matteis R, Flak MB, Gonzalez-Nunez M, Austin-Williams S, Palmas F, Colas RA and Dalli J (2022). Aspirin activates resolution pathways to reprogram T cell and macrophage responses in colitis-associated colorectal cancer. American Association for the Advancement of Science (AAAS) Science Advances vol. 8, (5) Kraft JD, Blomgran R, Bergström I, Soták M, Clark M, Rani A, Rajan MR, Dalli J, Nyström S, Quiding‐Järbrink M, Bromberg J, Skoog P and Börgeson E (2022). Lipoxins modulate neutrophil oxidative burst, integrin expression and lymphatic transmigration differentially in human health and atherosclerosis. Wiley The FASEB Journal vol. 36, (3) 2021
Reinertsen AF, Primdahl KG, De Matteis R, Dalli J and Hansen TV (2021). Stereoselective Synthesis, Configurational Assignment and Biological Evaluations of the Lipid Mediator RvD2n‐3 DPA. Wiley Chemistry - A European Journal vol. 28, (7) Beegun I, Koenis DS, Alusi G and Dalli J (2021). Dysregulated Maresin Concentrations in Plasma and Nasal Secretions From Patients With Chronic Rhinosinusitis. Frontiers Frontiers in Immunology vol. 12, Palmas F, Clarke J, Colas RA, Gomez EA, Keogh A, Boylan M, McEvoy N, McElvaney OJ, McElvaney O, Alalqam R, McElvaney NG, Curley GF and Dalli J (2021). Dysregulated plasma lipid mediator profiles in critically ill COVID-19 patients. Public Library of Science (PLoS) PLOS ONE vol. 16, (8) Piattini F, Matsushita M, Muri J, Bretscher P, Feng X, Freigang S, Dalli J, Schneider C and Kopf M (2021). Differential sensitivity of inflammatory macrophages and alternatively activated macrophages to ferroptosis. Wiley European Journal of Immunology vol. 51, (10) 2417-2429. Koenis DS, Beegun I, Jouvene CC, Aguirre GA, Souza PR, Gonzalez-Nunez M, Ly L, Pistorius K, Kocher HM, Ricketts W, Thomas G, Perretti M, Alusi G, Pfeffer P and Dalli J (2021). Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19. Circulation Research E54-E71. Marques RM, Gonzalez-Nunez M, Walker ME, Gomez EA, Colas RA, Montero-Melendez T, Perretti M and Dalli J (2021). Loss of 15-lipoxygenase disrupts Treg differentiation altering their pro-resolving functions. Springer Nature Cell Death & Differentiation vol. 28, (11) 3140-3160. Jagusch H, Werner M, Koenis D, Dalli J, Werz O and Pohnert G (2021). 14,17,18-Trihydroxy-Eicosatetraenoic Acid: A Novel Pro-Resolving Lipid Mediator from Marine Microalgae. American Chemical Society (ACS) ACS Pharmacology & Translational Science vol. 4, (3) 1188-1194. Rossaint J, Thomas K, Mersmann S, Skupski J, Margraf A, Tekath T, Jouvene CC, Dalli J, Hidalgo A, Meuth SG, Soehnlein O and Zarbock A (2021). Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education. Rockefeller University Press Journal of Experimental Medicine vol. 218, (7) Félix‐Soriano E, Sáinz N, Gil‐Iturbe E, Collantes M, Fernández‐Galilea M, Castilla‐Madrigal R, Ly L, Dalli J and Moreno‐Aliaga MJ (2021). Changes in brown adipose tissue lipid mediator signatures with aging, obesity, and DHA supplementation in female mice. Wiley The FASEB Journal vol. 35, (6) Sokal DM, McSloy A, Donegà M, Kirk J, Colas RA, Dolezalova N, Gomez EA, Gupta I, Fjordbakk CT, Ouchouche S, Matteucci PB, Schlegel K, Bashirullah R, Werling D, Harman K, Rowles A, Yazicioglu RF, Dalli J, Chew DJ and Perkins JD (2021). Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs. Frontiers Frontiers in Immunology vol. 12, Sogorb-Esteve A, Colas RA, Dalli J and Rohrer JD (2021). Differential Lipid Mediator Involvement in the Different Forms of Genetic Frontotemporal Dementia: Novel Insights into Neuroinflammation. IOS Press Journal of Alzheimer's Disease vol. 84, (1) 283-289. 2020
Sobrino A, Walker ME, Colas RA and Dalli J (2020). Protective activities of distinct omega-3 enriched oils are linked to their ability to upregulate specialized pro-resolving mediators. Public Library of Science (PLoS) PLOS ONE vol. 15, (12) Wood EG, Macdougall CE, Blythe H, Clément M, Colas RA, Dalli J, Marelli-Berg F and Longhi MP (2020). HIF1α activation in dendritic cells under sterile conditions promotes an anti-inflammatory phenotype through accumulation of intracellular lipids. Springer Nature Scientific Reports vol. 10, (1) Gomez EA, Colas RA, Souza PR, Hands R, Lewis MJ, Bessant C, Pitzalis C and Dalli J (2020). Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis. Springer Nature Nature Communications vol. 11, (1) Souza PR, Walker ME, Goulding NJ, Dalli J, Perretti M and Norling LV (2020). The GPR40 Agonist GW9508 Enhances Neutrophil Function to Aid Bacterial Clearance During E. coli Infections. Frontiers Media Frontiers in Immunology vol. 11, 573019-573019. Brancaleone V, Dalli J, di Villa Bianca RD and Pace S (2020). Editorial: Role of Blood Cells in Inflammatory and Vascular Disorders. Frontiers Frontiers in Pharmacology vol. 11, Chen J, Purvis GSD, Collotta D, Zoubi SA, Sugimoto MA, Cacace A, Martin L, Colas RA, Collino M, Dalli J and Thiemermann C (2020). RvE1 Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction and Enhances Bacterial Clearance. Frontiers Media Frontiers in Immunology vol. 11, 2080-2080. Schaller MS, Chen M, Colas RA, Sorrentino TA, Lazar AA, Grenon SM, Dalli J and Conte MS (2020). Treatment With a Marine Oil Supplement Alters Lipid Mediators and Leukocyte Phenotype in Healthy Patients and Those With Peripheral Artery Disease. Wolters Kluwer Journal of the American Heart Association vol. 9, (15) Allen BL, Montague-Cardoso K, Simeoli R, Colas RA, Oggero S, Vilar B, McNaughton PA, Dalli J, Perretti M, Sher E and Malcangio M (2020). Imbalance of proresolving lipid mediators in
persistent allodynia dissociated from signs of
clinical arthritis. Lippincott, Williams & Wilkins Pain Ruhanen H, Haridas PAN, Minicocci I, Taskinen JH, Palmas F, di Costanzo A, D'Erasmo L, Metso J, Partanen J, Dalli J, Zhou Y, Arca M, Jauhiainen M, Käkelä R and Olkkonen VM (2020). ANGPTL3 deficiency alters the lipid profile and metabolism of cultured hepatocytes and human lipoproteins. Elsevier Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids vol. 1865, (7) Määttänen P, Lurz E, Botts SR, Wu RY, Robinson SC, Yeung CW, Colas R, Li B, Johnson‐Henry KC, Surette ME, Dalli J and Sherman PM (2020). Plant‐ and Fish‐Derived n‐3 PUFAs Suppress Citrobacter Rodentium–Induced Colonic Inflammation. Wiley Molecular Nutrition & Food Research vol. 64, (6) Pangopoulos MK, Nolsøe JMN, Antonsen SG, Colas RA, Dalli J, Aursnes M, Stenstrøm Y and Hansen TV (2020). Enzymatic studies with 3-oxa n-3 DPA. Elsevier Bioorganic Chemistry vol. 96, 
Wilcz‐Villega E, Carter E, Ironside A, Xu R, Mataloni I, Holdsworth J, Jones W, Moreno Béjar R, Uhlik L, Bentham RB, Godinho SA, Dalli J, Grose R, Szabadkai G, Jones L, Hodivala‐Dilke K and Bianchi K (2020). Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway. Springer Nature EMBO Molecular Medicine vol. 12, (2) Fussbroich D, Colas RA, Eickmeier O, Trischler J, Jerkic SP, Zimmermann K, Göpel A, Schwenger T, Schaible A, Henrich D, Baer P, Zielen S, Dalli J, Beermann C and Schubert R (2020). A combination of LCPUFA ameliorates airway inflammation in asthmatic mice by promoting pro-resolving effects and reducing adverse effects of EPA. Elsevier Mucosal Immunology vol. 13, (3) 481-492. 2019
Souza PR, Marques RM, Gomez EA, Colas RA, De Matteis R, Zak A, Patel M, Collier DJ and Dalli J (2019). Enriched Marine Oil Supplements Increase Peripheral Blood Specialized Pro-Resolving Mediators Concentrations and Reprogram Host Immune Responses: A Randomized Double-Blind Placebo-Controlled Study. Circ Res Flak MB, Koenis DS, Sobrino A, Smith J, Pistorius K, Palmas F and Dalli J (2019). GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in arthritis and infections. American Society for Clinical Investigation Journal of Clinical Investigation vol. 130, (1) 359-373. Shivakoti R, Dalli J, Kadam D, Gaikwad S, Barthwal M, Colas RA, Mazzacuva F, Lokhande R, Dharmshale S, Bharadwaj R, Kagal A, Pradhan N, Deshmukh S, Atre S, Sahasrabudhe T, Kakrani A, Kulkarni V, Raskar S, Suryavanshi N, Chon S, Gupte A, Gupta A, Gupte N, Arriaga MB, Fukutani KF, Andrade BB, Golub JE and Mave V (2019). Lipid mediators of inflammation and Resolution in individuals with tuberculosis and tuberculosis-Diabetes. Elsevier Prostaglandins and Other Lipid Mediators vol. 147, Tungen JE, Gerstmann L, Vik A, De Matteis R, Colas RA, Dalli J, Chiang N, Serhan CN, Kalesse M and Hansen TV (2019). Addendum: Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1n−3 DPA. Wiley Chemistry - A European Journal vol. 25, (66) 15212-15212. Colas RA, Nhat LTH, Thuong NTT, Gómez EA, Ly L, Thanh HH, Mai NTH, Phu NH, Thwaites GE and Dalli J (2019). Proresolving mediator profiles in cerebrospinal fluid are linked with disease severity and outcome in adults with tuberculous meningitis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol. 33, (11) 13028-13039. Thau-Zuchman O, Ingram R, Harvey GG, Cooke T, Palmas F, Pallier PN, Brook J, Priestley JV, Dalli J, Tremoleda JL and Michael-Titus AT (2019). A Single Injection of Docosahexaenoic Acid Induces a Pro-Resolving Lipid Mediator Profile in the Injured Tissue and a Long-Lasting Reduction in Neurological Deficit after Traumatic Brain Injury in Mice. Mary Ann Liebert Journal of Neurotrauma vol. 37, (1) 66-79. Nesman JI, Primdahl KG, Tungen JE, Palmas F, Dalli J and Hansen TV (2019). Synthesis, Structural Confirmation, and Biosynthesis of 22-OH-PD1n-3 DPA †. MDPI Molecules vol. 24, (18) Becares N, Härmälä S, China L, Colas RA, Maini AA, Bennet K, Skene SS, Shabir Z, Dalli J and O’Brien A (2019). Immune Regulatory Mediators in Plasma from Patients With Acute Decompensation Are Associated With 3-Month Mortality. Elsevier Clinical Gastroenterology and Hepatology vol. 18, (5) 1207-1215.e6. Dakin SG, Colas RA, Wheway K, Watkins B, Appleton L, Rees J, Gwilym S, Little C, Dalli J and Carr AJ (2019). Proresolving Mediators LXB4 and RvE1 Regulate Inflammation in Stromal Cells from Patients with Shoulder Tendon Tears. Elsevier American Journal Of Pathology vol. 189, (11) 2258-2268. Fosshaug LE, Colas RA, Anstensrud AK, Gregersen I, Nymo S, Sagen EL, Michelsen A, Vinge LE, Øie E, Gullestad L, Halvorsen B, Hansen TV, Aukrust P, Dalli J and Yndestad A (2019). Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction. Elsevier EBioMedicine vol. 46, 264-273. Flak MB, Colas RA, Muñoz-Atienza E, Curtis MA, Dalli J and Pitzalis C (2019). Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis. American Society for Clinical Investigation JCI Insight vol. 4, (13) Dakin SG, Colas RA, Newton J, Gwilym S, Jones N, Reid HAB, Wood S, Appleton L, Wheway K, Watkins B, Dalli J and Carr AJ (2019). 15-Epi-LXADakin SG, Colas RA, Dean BJF, Wheway K, Watkins B, Dalli J and Carr AJ (2019). Tendon cells isolated from patients with persistent shoulder tendinopathy show dysregulated resolution responses. Hindawi Translational Sports Medicine vol. 2, (4) 173-176. Holopainen M, Colas RA, Valkonen S, Tigistu-Sahle F, Hyvärinen K, Mazzacuva F, Lehenkari P, Käkelä R, Dalli J, Kerkelä E and Laitinen S (2019). Polyunsaturated fatty acids modify the extracellular vesicle membranes and increase the production of proresolving lipid mediators of human mesenchymal stromal cells. Elsevier Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids vol. 1864, (10) 1350-1362. Sordi R, Chiazza F, Collotta D, Migliaretti G, Colas RA, Vulliamy P, Brohi K, Dalli J, Collino M and Thiemermann C (2019). Resolvin D1 Attenuates the Organ Injury Associated With Experimental Hemorrhagic Shock. Ann Surg López-Vicario C, Titos E, Walker ME, Alcaraz-Quiles J, Casulleras M, Durán-Güell M, Flores-Costa R, Pérez-Romero N, Forné M, Dalli J and Clària J (2019). Leukocytes from obese individuals exhibit an impaired SPM signature. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol. 33, (6) 7072-7083. Valkonen S, Holopainen M, Colas RA, Impola U, Dalli J, Käkelä R, Siljander PR-M and Laitinen S (2019). Lipid mediators in platelet concentrate and extracellular vesicles: Molecular mechanisms from membrane glycerophospholipids to bioactive molecules. Elsevier Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids vol. 1864, (8) 1168-1182. Sønderskov J, Tungen JE, Palmas F, Dalli J, Serhan CN, Stenstrøm Y and Vidar Hansen T (2019). Stereoselective synthesis of MaR2Dalli J, Pistorius K and Walker ME (2019). Novel n-3 Docosapentaneoic Acid-Derived Pro-resolving Mediators Are Vasculoprotective and Mediate the Actions of Statins in Controlling Inflammation. Springer Verlag Advances in Experimental Medicine and Biology vol. 1161, 65-75. 2018
Tungen JE, Gerstmann L, Vik A, De Matteis R, Colas RA, Dalli J, Chiang N, Serhan CN, Kalesse M and Hansen TV (2018). Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1n-3 DPA. Chemistry vol. 25, (6) 1476-1480. Serhan CN, Chiang N and Dalli J (2018). New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration. Mol Aspects Med vol. 64, 1-17. Laguna-Fernandez A, Checa A, Carracedo M, Artiach G, Petri MH, Baumgartner R, Forteza MJ, Jiang X, Andonova T, Walker ME, Dalli J, Arnardottir H, Gisterå A, Thul S, Wheelock CE, Paulsson-Berne G, Ketelhuth DFJ, Hansson GK and Bäck M (2018). ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages. Circulation vol. 138, (16) 1693-1705. Frigerio F, Pasqualini G, Craparotta I, Marchini S, van Vliet EA, Foerch P, Vandenplas C, Leclercq K, Aronica E, Porcu L, Pistorius K, Colas RA, Hansen TV, Perretti M, Kaminski RM, Dalli J and Vezzani A (2018). n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis. Brain vol. 141, (11) 3130-3143. Chiang N, Riley IR, Dalli J, Rodriguez AR, Spur BW and Serhan CN (2018). New maresin conjugates in tissue regeneration pathway counters leukotriene D4–stimulated vascular responses. FASEB The FASEB Journal vol. 32, (7) 4043-4052. Chen J, Hamers AJP, Finsterbusch M, Massimo G, Zafar M, Corder R, Colas RA, Dalli J, Thiemermann C and Ahluwalia A (2018). Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis. FASEB J fj201701303-fj201701303. Pistorius K, Souza PR, De Matteis R, Austin-Williams S, Primdahl KG, Vik A, Mazzacuva F, Colas RA, Marques RM, Hansen TV and Dalli J (2018). PDn-3 DPA Pathway Regulates Human Monocyte Differentiation and Macrophage Function. Cell Chem Biol vol. 25, (6) 749-760.e9. Dalli J and Serhan CN (2018). Identification and structure elucidation of the pro‐resolving mediators provides novel leads for resolution pharmacology. Wiley British Journal of Pharmacology vol. 176, (8) 1024-1037. Colas RA, Ashton AW, Mukherjee S, Dalli J, Akide-Ndunge OB, Huang H, Desruisseaux MS, Guan F, Jelicks LA, dos Santos FM, Nagajyothi J, Zingman MA, Reyes J, Weiss LM, Serhan CN and Tanowitz HB (2018). Trypanosoma cruzi produces the specialized proresolving mediators resolvin D1, resolvin D5, and resolvin E2. Infection and Immunity vol. 86, (4) Motwani MP, Colas RA, George MJ, Flint JD, Dalli J, Richard-Loendt A, De Maeyer RPH, Serhan CN and Gilroy DW (2018). Pro-resolving mediators promote resolution in a human skin model of UV-killed Escherichia coli–driven acute inflammation. American Society for Clinical Investigation JCI Insight vol. 3, (6) Mai NTH, Dobbs N, Phu NH, Colas RA, Thao LTP, Thuong NTT, Nghia HDT, Hanh NHH, Hang NT, Heemskerk AD, Day JN, Ly L, Thu DDA, Merson L, Kestelyn E, Wolbers M, Geskus R, Summers D, Chau NVV, Dalli J and Thwaites GE (2018). A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults. eLife eLife vol. 7, Colas RA, Souza PR, Walker ME, Burton M, Zasłona Z, Curtis AM, Marques RM and Dalli J (2018). Impaired Production and Diurnal Regulation of Vascular RvDn-3 DPA Increase Systemic Inflammation and Cardiovascular Disease. Wolters Kluwer Circulation Research vol. 122, (6) 855-863. Dalli J, Colas RA, Walker ME and Serhan CN (2018). Lipid Mediator Metabolomics Via LC-MS/MS Profiling and Analysis. Methods Mol Biol vol. 1730, 59-72. 2017
Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR, Schmidt B, Dalli J, Greene ER, Gus-Brautbar Y, Piwowarski J, Mammoto T, Zurakowski D, Perretti M, Sukhatme VP, Kaipainen A, Kieran MW, Huang S and Panigrahy D (2017). Resolvins suppress tumor growth and enhance cancer therapy. Rockefeller University Press Journal of Experimental Medicine vol. 215, (1) 115-140. Dalli J and Serhan CN (2017). Immunoresolvents signaling molecules at intersection between the brain and immune system. Elsevier Current Opinion in Immunology vol. 50, 48-54. Dalli J and Serhan CN (2017). Pro-Resolving Mediators in Regulating and Conferring Macrophage Function. Frontiers Media Front Immunol vol. 8, 1400-1400. Motwani MP, Newson J, Kwong S, Richard-Loendt A, Colas R, Dalli J and Gilroy DW (2017). Prolonged immune alteration following resolution of acute inflammation in humans. Public Library of Science PLoS One vol. 12, (10) e0186964-e0186964. Primdahl KG, Tungen JE, De Souza PRS, Colas RA, Dalli J, Hansen TV and Vik A (2017). Stereocontrolled synthesis and investigation of the biosynthetic transformations of 16(S),17(S)-epoxy-PDn-3 DPA. Org Biomol Chem vol. 15, (40) 8606-8613. Lee S, Nakahira K, Dalli J, Siempos II, Norris PC, Colas RA, Moon J-S, Shinohara M, Hisata S, Howrylak JA, Suh G-Y, Ryter SW, Serhan CN and Choi AMK (2017). NLRP3 Inflammasome Deficiency Protects against Microbial Sepsis via Increased Lipoxin B4Synthesis. Am J Respir Crit Care Med vol. 196, (6) 713-726. Dakin SG, Ly L, Colas RA, Oppermann U, Wheway K, Watkins B, Dalli J and Carr AJ (2017). Increased 15-PGDH expression leads to dysregulated resolution responses in stromal cells from patients with chronic tendinopathy. Macmillan Publishing Group Sci Rep vol. 7, (1) 11009-11009. China L, Maini A, Skene SS, Shabir Z, Sylvestre Y, Colas RA, Ly L, Salles NB, Belloti V, Dalli J, Gilroy DW and O’Brien A (2017). Albumin Counteracts Immune-Suppressive Effects of Lipid Mediators in Patients With Advanced Liver Disease. Elsevier Clinical Gastroenterology and Hepatology vol. 16, (5) 738-747.e7. Walker ME, Souza PR, Colas RA and Dalli J (2017). 13‐Series resolvins mediate the leukocyte‐platelet actions of atorvastatin and pravastatin in inflammatory arthritis. Wiley The FASEB Journal vol. 31, (8) 3636-3648. Reátegui E, Jalali F, Khankhel AH, Wong E, Cho H, Lee J, Serhan CN, Dalli J, Elliott H and Irimia D (2017). Microscale arrays for the profiling of start and stop signals coordinating human-neutrophil swarming. Nature Biomedical Engineering vol. 1, (7) 0094-0094. Hansen TV, Dalli J and Serhan CN (2017). The Novel Lipid Mediator PD1n-3DPA: An Overview of the Structural Elucidation, Synthesis, Biosynthesis and Bioactions. Elsevier Prostaglandins and Other Lipid Mediators Perretti M, Di Filippo C, D'Amico M and Dalli J (2017). Characterizing the anti-inflammatory and tissue protective actions of a novel Annexin A1 peptide. Public Library of Science PLoS One vol. 12, (4) e0175786-e0175786. Dalli J (2017). Does promoting resolution instead of inhibiting inflammation represent the new paradigm in treating infections? Elsevier Molecular Aspects of Medicine vol. 58, 12-20. Vik A, Dalli J and Hansen TV (2017). Recent advances in the chemistry and biology of anti-inflammatory and specialized pro-resolving mediators biosynthesized from n-3 docosapentaenoic acid. Elsevier Bioorganic & Medicinal Chemistry Letters vol. 27, (11) 2259-2266. PERRETTI M, Dalli J, Colas R, Federici Canova D and Gobbetti T (2017). Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection. National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 114, (15) 3963-3968. Norling LV, Ly L and Dalli J (2017). Resolving inflammation by using nutrition therapy: roles for specialized proresolving mediators. Curr Opin Clin Nutr Metab Care vol. 20, (2) 145-152. Dalli J, Colas RA, Arnardottir H and Serhan CN (2017). Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution. Immunity vol. 46, (1) 92-105. Freire MO, Dalli J, Serhan CN and Van Dyke TE (2017). Neutrophil Resolvin E1 Receptor Expression and Function in Type 2 Diabetes. The American Association of Immunologists The Journal of Immunology vol. 198, (2) 718-728. Dalli J and Serhan C (2017). Macrophage Proresolving Mediators—the When and Where. Myeloid Cells in Health and Disease American Society for Microbiology Perretti M, Cooper D, Dalli J and Norling LV (2017). Immune resolution mechanisms in inflammatory arthritis. Nat Rev Rheumatol vol. 13, (2) 87-99. China L, Maini A, Colas R, Ly L, Dalli J, Gilroy D, O’Brien A and Group ATM (2017). FRI-054 Plasma lipid mediator (LM) profiling identifies hyper- and hypo-activated groups of patients with ACLF and targeted 20% human albumin solution infusion recalibrates abnormalities. Elsevier Journal of Hepatology vol. 66, (1) 2016
Colas RA, Dalli J, Chiang N, Vlasakov I, Sanger JM, Riley IR and Serhan CN (2016). Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation. J Immunol vol. 197, (11) 4444-4452. AHLUWALIA A (2016). Accelerated resolution underlies sex differences in the inflammatory response in human. American Society for Clinical Investigation Journal of Clinical Investigation vol. 127, (1) 169-182. Tsoyi K, Hall SRR, Dalli J, Colas RA, Ghanta S, Ith B, Coronata A, Fredenburgh LE, Baron RM, Choi AMK, Serhan CN, Liu X and Perrella MA (2016). Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators*. Wolters Kluwer Critical Care Medicine vol. 44, (12) e1236-e1245. Primdahl KG, Aursnes M, Walker ME, Colas RA, Serhan CN, Dalli J, Hansen TV and Vik A (2016). Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins. J Nat Prod vol. 79, (10) 2693-2702. Titos E, Rius B, López-Vicario C, Alcaraz-Quiles J, García-Alonso V, Lopategi A, Dalli J, Lozano JJ, Arroyo V, Delgado S, Serhan CN and Clària J (2016). Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue. The American Association of Immunologists The Journal of Immunology vol. 197, (8) 3360-3370. DALLI J (2016). Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages. National Academy of Sciences Proceedings of the National Academy of Sciences of USA vol. 113, (43) DALLI J and Colas RC (2016). Human Sepsis Eicosanoid and Proresolving Lipid Mediator Temporal Profiles: Correlations With Survival and Clinical Outcomes. Lippincott, Williams & Wilkins Critical Care Medicine DALLI JP (2016). Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses. American Association for the Advancement of Science Science Translational Medicine vol. 8, (353) Arnardottir HH, Dalli J, Norling LV, Colas RA, Perretti M and Serhan CN (2016). Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. American Association of Immunologists Journal of Immunology vol. 197, (6) 2362-2368. Dalli J, Chiang N and Serhan C (2016). AB0042 Identification of Sulfido-Conjugated Mediators That Promote Resolution of Infection and Organ Protection. BMJ Annals of the Rheumatic Diseases vol. 75, (Suppl 2) Colby JK, Abdulnour R-EE, Sham HP, Dalli J, Colas RA, Winkler JW, Hellmann J, Wong B, Cui Y, El-Chemaly S, Petasis NA, Spite M, Serhan CN and Levy BD (2016). Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia. Elsevier American Journal Of Pathology vol. 186, (7) 1801-1813. Dalli J and Serhan C (2016). Macrophage Proresolving Mediators—the When and Where. American Society for Microbiology Microbiology Spectrum vol. 4, (3) Elajami TK, Colas RA, Dalli J, Chiang N, Serhan CN and Welty FK (2016). Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling. Wiley The FASEB Journal vol. 30, (8) 2792-2801. Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN and Perretti M (2016). Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. American Society for Clinical Investigation JCI Insight vol. 1, (5) Dalli J (2016). LIPID MEDIATORS AND THE RESOLUTION OF CHRONIC INFLAMMATION: IMPLICATIONS FOR ARTHRITIS THERAPY. OSTEOARTHRITIS AND CARTILAGE vol. 24, S2-S2. Dalli J, Sanger JM, Rodriguez AR, Chiang N, Spur BW and Serhan CN (2016). Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3. Public Library of Science (PLoS) PLOS ONE vol. 11, (2) Ramon S, Dalli J, Sanger JM, Winkler JW, Aursnes M, Tungen JE, Hansen TV and Serhan CN (2016). The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation. Elsevier American Journal Of Pathology vol. 186, (4) 962-973. Winkler JW, Orr SK, Dalli J, Cheng C-YC, Sanger JM, Chiang N, Petasis NA and Serhan CN (2016). Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance. Springer Nature Scientific Reports vol. 6, (1) Hansen TV, Dalli J and Serhan CN (2016). Selective identification of specialized pro-resolving lipid mediators from their biosynthetic double di-oxygenation isomers. Royal Society of Chemistry (RSC) RSC Advances vol. 6, (34) 28820-28829. Fiala M, Terrando N and Dalli J (2016). Specialized Pro-Resolving Mediators from Omega-3 Fatty Acids Improve Amyloid-β Phagocytosis and Regulate Inflammation in Patients with Minor Cognitive Impairment. IOS Press Journal of Alzheimer's Disease vol. 49, (4) 1191-1191. 2015
Wang C-W, Colas RA, Dalli J, Arnardottir HH, Nguyen D, Hasturk H, Chiang N, Van Dyke TE and Serhan CN (2015). Maresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes. American Society for Microbiology Infection and Immunity vol. 84, (3) 658-665. Abdulnour RE, Sham HP, Douda DN, Colas RA, Dalli J, Bai Y, Ai X, Serhan CN and Levy BD (2015). Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation. Elsevier Mucosal Immunology vol. 9, (5) 1278-1287. Cianci E, Recchiuti A, Trubiani O, Diomede F, Marchisio M, Miscia S, Colas RA, Dalli J, Serhan CN and Romano M (2015). Human Periodontal Stem Cells Release Specialized Proresolving Mediators and Carry Immunomodulatory and Prohealing Properties Regulated by Lipoxins. Oxford University Press (OUP) Stem Cells Translational Medicine vol. 5, (1) 20-32. Aursnes M, Tungen JE, Colas RA, Vlasakov I, Dalli J, Serhan CN and Hansen TV (2015). Synthesis of the 16S,17S‑Epoxyprotectin Intermediate in the Biosynthesis of Protectins by Human Macrophages. American Chemical Society (ACS) Journal of Natural Products vol. 78, (12) 2924-2931. Arnardottir H, Orr SK, Dalli J and Serhan CN (2015). Human milk proresolving mediators stimulate resolution of acute inflammation. Elsevier Mucosal Immunology vol. 9, (3) 757-766. Dalli J, Kraft BD, Colas RA, Shinohara M, Fredenburgh LE, Hess DR, Chiang N, Welty-Wolf K, Choi AM, Piantadosi CA and Serhan CN (2015). The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide. American Thoracic Society American Journal of Respiratory Cell and Molecular Biology vol. 53, (3) 314-325. Croasdell A, Thatcher TH, Kottmann RM, Colas RA, Dalli J, Serhan CN, Sime PJ and Phipps RP (2015). Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages. American Physiological Society American Journal of Physiology - Lung Cellular and Molecular Physiology vol. 309, (8) l888-l901. Dalli J, Chiang N and Serhan CN (2015). Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections. Springer Nature Nature Medicine vol. 21, (9) 1071-1075. Chiang N, Dalli J, Colas RA and Serhan CN (2015). Identification of resolvin D2 receptor mediating resolution of infections and organ protection. Rockefeller University Press Journal of Experimental Medicine vol. 212, (8) 1203-1217. Ramirez JL, de Almeida Oliveira G, Calvo E, Dalli J, Colas RA, Serhan CN, Ribeiro JM and Barillas-Mury C (2015). A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae. Springer Nature Nature Communications vol. 6, (1) Börgeson E, Johnson AMF, Lee YS, Till A, Syed GH, Ali-Shah ST, Guiry PJ, Dalli J, Colas RA, Serhan CN, Sharma K and Godson C (2015). Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease. Elsevier Cell Metabolism vol. 22, (1) 125-137. Kain V, Ingle KA, Colas RA, Dalli J, Prabhu SD, Serhan CN, Joshi M and Halade GV (2015). Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function. Elsevier Journal of Molecular and Cellular Cardiology vol. 84, 24-35. Serhan CN, Chiang N and Dalli J (2015). The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution. Elsevier Seminars in Immunology vol. 27, (3) 200-215. Dalli J, Chiang N and Serhan C (2015). Novel Peptide‐Conjugated Maresins Stimulate Tissue Regeneration and Clearance of Infections in Planaria and Inflammatory Exudates. Wiley The FASEB Journal vol. 29, (S1) Sulciner M, Mudge D, Ramon S, Dalli J, Kieran M, Huang S, Serhan C and Panigrahy D (2015). Suppression of Cell Debris‐Stimulated Tumor Growth by Resolvin Mediated Clearance. Wiley The FASEB Journal vol. 29, (S1) Winkler J, Orr S, Dalli J, Chiang N, Petasis N and Serhan C (2015). Resolvin D4 Potent Antiiinflammatory Proresolving Actions Confirmed via Total Synthesis. Wiley The FASEB Journal vol. 29, (S1) Ramon S, Dalli J, Norris P, Colas R and Serhan C (2015). Elucidation of Resolvin and Protectin Sulfido‐Conjugated Mediators: New Pro‐Resolving and Tissue Regenerative Pathways. Wiley The FASEB Journal vol. 29, (S1) Arnardottir H, Orr S, Dalli J and Serhan C (2015). Human Milk Stimulates Resolution of Acute Inflammation. Wiley The FASEB Journal vol. 29, (S1) Orr SK, Colas RA, Dalli J, Chiang N and Serhan CN (2015). Proresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent. American Physiological Society American Journal of Physiology - Lung Cellular and Molecular Physiology vol. 308, (9) l904-l911. Amoruso A, Fresu LG, Dalli J, Miglietta D, Bardelli C, Canova DF, Perretti M and Brunelleschi S (2015). Characterization of the anti-inflammatory properties of NCX 429, a dual-acting compound releasing nitric oxide and naproxen. Elsevier Life Sciences vol. 126, 28-36. Dalli J, Ramon S, Norris PC, Colas RA and Serhan CN (2015). Novel proresolving and tissue‐regenerative resolvin and protectin sulfido‐conjugated pathways. Wiley The FASEB Journal vol. 29, (5) 2120-2136. Krishnamoorthy N, Burkett PR, Dalli J, Abdulnour R-EE, Colas R, Ramon S, Phipps RP, Petasis NA, Kuchroo VK, Serhan CN and Levy BD (2015). Cutting Edge: Maresin-1 Engages Regulatory T Cells To Limit Type 2 Innate Lymphoid Cell Activation and Promote Resolution of Lung Inflammation. The American Association of Immunologists The Journal of Immunology vol. 194, (3) 863-867. Fiala M, Terrando N and Dalli J (2015). Specialized Pro-Resolving Mediators from Omega-3 Fatty Acids Improve Amyloid-β Phagocytosis and Regulate Inflammation in Patients with Minor Cognitive Impairment. IOS Press Journal of Alzheimer's Disease vol. 48, (2) 293-301. 2014
Van Dyke TE, Hasturk H, Kantarci A, Freire MO, Nguyen D, Dalli J and Serhan CN (2014). Proresolving Nanomedicines Activate Bone Regeneration in Periodontitis. SAGE Publications Journal of Dental Research vol. 94, (1) 148-156. Abdulnour R-EE, Dalli J, Colby JK, Krishnamoorthy N, Timmons JY, Tan SH, Colas RA, Petasis NA, Serhan CN and Levy BD (2014). Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 111, (46) 16526-16531. Tungen JE, Aursnes M, Dalli J, Arnardottir H, Serhan CN and Hansen TV (2014). Total synthesis of the anti-inflammatory and pro-resolving lipid mediator MaR1n-3 DPA utilizing an sp(3) -sp(3) Negishi cross-coupling reaction. Chemistry vol. 20, (45) 14575-14578. Serhan CN, Chiang N, Dalli J and Levy BD (2014). Lipid Mediators in the Resolution of Inflammation. Cold Spring Harbor Laboratory Cold Spring Harbor Perspectives in Biology vol. 7, (2) Dalli J, Colas RA and Serhan CN (2014). Erratum: CORRIGENDUM: Novel n-3 Immunoresolvents: Structures and Actions. Springer Nature Scientific Reports vol. 4, (1) Tungen JE, Aursnes M, Dalli J, Arnardottir H, Serhan CN and Hansen TV (2014). Cover Picture: Total Synthesis of the Anti‐inflammatory and Pro‐resolving Lipid Mediator MaR1n−3 DPA Utilizing an sp3–sp3 Negishi Cross‐Coupling Reaction (Chem. Eur. J. 45/2014). Wiley Chemistry - A European Journal vol. 20, (45) 14533-14533. Dalli J, Chiang N and Serhan CN (2014). Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 111, (44) e4753-e4761. Frediani JK, Jones DP, Tukvadze N, Uppal K, Sanikidze E, Kipiani M, Tran VT, Hebbar G, Walker DI, Kempker RR, Kurani SS, Colas RA, Dalli J, Tangpricha V, Serhan CN, Blumberg HM and Ziegler TR (2014). Plasma Metabolomics in Human Pulmonary Tuberculosis Disease: A Pilot Study. Public Library of Science (PLoS) PLOS ONE vol. 9, (10) Arnardottir HH, Dalli J, Colas RA, Shinohara M and Serhan CN (2014). Aging Delays Resolution of Acute Inflammation in Mice: Reprogramming the Host Response with Novel Nano-Proresolving Medicines. The American Association of Immunologists The Journal of Immunology vol. 193, (8) 4235-4244. Tungen JE, Aursnes M, Vik A, Ramon S, Colas RA, Dalli J, Serhan CN and Hansen TV (2014). Synthesis and Anti-inflammatory and Pro-resolving Activities of 22-OH-PD1, a Monohydroxylated Metabolite of Protectin D1. American Chemical Society (ACS) Journal of Natural Products vol. 77, (10) 2241-2247. Tungen JE, Aursnes M, Dalli J, Arnardottir H, Serhan CN and Hansen TV (2014). Total Synthesis of the Anti‐inflammatory and Pro‐resolving Lipid Mediator MaR1n−3 DPA Utilizing an sp3–sp3 Negishi Cross‐Coupling Reaction. Wiley Chemistry - A European Journal vol. 20, (45) 14575-14578. Shinohara M, Kibi M, Riley IR, Chiang N, Dalli J, Kraft BD, Piantadosi CA, Choi AMK and Serhan CN (2014). Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1. American Physiological Society American Journal of Physiology - Lung Cellular and Molecular Physiology vol. 307, (10) l746-l757. Serhan CN, Dalli J, Colas RA, Winkler JW and Chiang N (2014). Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. Elsevier Biochimica et Biophysica Acta vol. 1851, (4) 397-413. Deng B, Wang C-W, Arnardottir HH, Li Y, Cheng C-YC, Dalli J and Serhan CN (2014). Maresin Biosynthesis and Identification of Maresin 2, a New Anti-Inflammatory and Pro-Resolving Mediator from Human Macrophages. Public Library of Science (PLoS) PLOS ONE vol. 9, (7) Nadkarni S, Dalli J, Hollywood J, Mason JC, Dasgupta B and Perretti M (2014). 15. Neutrophils in GCA. Oxford University Press (OUP) Rheumatology vol. 53, (suppl_2) i9-i9. McCauley LK, Dalli J, Koh AJ, Chiang N and Serhan CN (2014). Cutting Edge: Parathyroid Hormone Facilitates Macrophage Efferocytosis in Bone Marrow via Proresolving Mediators Resolvin D1 and Resolvin D2. The American Association of Immunologists The Journal of Immunology vol. 193, (1) 26-29. Aursnes M, Tungen JE, Vik A, Dalli J and Hansen TV (2014). ChemInform Abstract: Stereoselective Synthesis of Protectin D1: A Potent Antiinflammatory and Proresolving Lipid Mediator. Wiley ChemInform vol. 45, (26) no-no. Mirakaj V, Dalli J, Granja T, Rosenberger P and Serhan CN (2014). Vagus nerve controls resolution and pro-resolving mediators of inflammation. Rockefeller University Press Journal of Experimental Medicine vol. 211, (6) 1037-1048. Colas RA, Shinohara M, Dalli J, Chiang N and Serhan CN (2014). Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue. American Physiological Society American Journal of Physiology - Cell Physiology vol. 307, (1) c39-c54. Frediani J, Jones D, Tukvadze N, Sanikidze E, Kipiani M, Uppal K, Kurani S, Hebbar G, Colas R, Dalli J, Serhan C, Tangpricha V, Blumberg H and Ziegler T (2014). Plasma high‐resolution metabolomic profiling reveals upregulation of specific resolvins in patients with pulmonary tuberculosis (248.3). Wiley The FASEB Journal vol. 28, (S1) Aursnes M, Tungen JE, Vik A, Colas R, Cheng C-YC, Dalli J, Serhan CN and Hansen TV (2014). Total Synthesis of the Lipid Mediator PD1n‑3 DPA: Configurational Assignments and Anti-inflammatory and Pro-resolving Actions. American Chemical Society (ACS) Journal of Natural Products vol. 77, (4) 910-916. Nadkarni S, Dalli J, Hollywood J, Mason JC, Dasgupta B and Perretti M (2014). Investigational analysis reveals a potential role for neutrophils in giant-cell arteritis disease progression. Circ Res vol. 114, (2) 242-248. Dalli J, Norling LV, Montero-Melendez T, Federici Canova D, Lashin H, Pavlov AM, Sukhorukov GB, Hinds CJ and Perretti M (2014). Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. EMBO Mol Med vol. 6, (1) 27-42. Serhan CN, Chiang N and Dalli J (2014). Macrophages and the Entrance of Resolution Phase Lipid Mediators. Macrophages: Biology and Role in the Pathology of Diseases Springer Nature Aursnes M, Tungen JE, Vik A, Dalli J and Hansen TV (2014). Stereoselective synthesis of protectin D1: a potent anti-inflammatory and proresolving lipid mediator. Royal Society of Chemistry (RSC) Organic & Biomolecular Chemistry vol. 12, (3) 432-437. 2013
Li Y, Dalli J, Chiang N, Baron RM, Quintana C and Serhan CN (2013). Plasticity of Leukocytic Exudates in Resolving Acute Inflammation Is Regulated by MicroRNA and Proresolving Mediators. Elsevier Immunity vol. 39, (5) 885-898. Divanovic S, Dalli J, Jorge-Nebert LF, Flick LM, Gálvez-Peralta M, Boespflug ND, Stankiewicz TE, Fitzgerald JM, Somarathna M, Karp CL, Serhan CN and Nebert DW (2013). Contributions of the Three CYP1 Monooxygenases to Pro-Inflammatory and Inflammation-Resolution Lipid Mediator Pathways. The American Association of Immunologists The Journal of Immunology vol. 191, (6) 3347-3357. Norling LV and Dalli J (2013). Microparticles are novel effectors of immunity. Curr Opin Pharmacol vol. 13, (4) 570-575. Dalli J, Montero-Melendez T, Norling LV, Yin X, Hinds C, Haskard D, Mayr M and Perretti M (2013). Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. Mol Cell Proteomics vol. 12, (8) 2205-2219. Dalli J, Consalvo AP, Ray V, Di Filippo C, D'Amico M, Mehta N and Perretti M (2013). Proresolving and tissue-protective actions of annexin A1-based cleavage-resistant peptides are mediated by formyl peptide receptor 2/lipoxin A4 receptor. J Immunol vol. 190, (12) 6478-6487. Chiang N, Shinohara M, Dalli J, Mirakaj V, Kibi M, Choi AMK and Serhan CN (2013). Inhaled Carbon Monoxide Accelerates Resolution of Inflammation via Unique Proresolving Mediator–Heme Oxygenase-1 Circuits. The American Association of Immunologists The Journal of Immunology vol. 190, (12) 6378-6388. Montero-Melendez T, Dalli J and Perretti M (2013). Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors. Cell Death Differ vol. 20, (4) 567-575. Dalli J and Serhan C (2013). Pro‐Resolving Mediator Production by Human Phagocytes and their Transcellular Biosynthesis with Microparticles in Inflammation‐Resolution. Wiley The FASEB Journal vol. 27, (S1) 1168.4-1168.4. Li Y, Fredman G, Dalli J, Chiang N and Serhan CN (2013). Temporal Regulation of Pro‐Resolving Mediators and MicroRNA in Self‐Limited versus Delayed Resolution of Acute Inflammation. Wiley The FASEB Journal vol. 27, (S1) 816.4-816.4. Gao F, Dalli J, Claria J and Serhan CN (2013). E. coli peritonitis initiates D‐series Resolvin‐metabolome. Wiley The FASEB Journal vol. 27, (S1) 822.9-822.9. Shinohara M, Chiang N, Dalli J, Mirakaj V, Choi AMK and Serhan CN (2013). Inhaled Carbon Monoxide Accelerates Resolution of Inflammation via Novel Pro‐resolving Mediators and Heme Oxygenase‐1. Wiley The FASEB Journal vol. 27, (S1) 649.2-649.2. Dalli J, Karamnov S, Zhu M, Petasis N and Serhan CN (2013). Maresin 1 a Novel Macrophage n‐3 Derived Mediator is a Potent Tissue Regenerative Immunoresolvent. Wiley The FASEB Journal vol. 27, (S1) 379.11-379.11. Dalli J, Zhu M, Vlasenko NA, Deng B, Haeggström JZ, Petasis NA and Serhan CN (2013). The novel 13S,14S ‐epoxy‐maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype. Wiley The FASEB Journal vol. 27, (7) 2573-2583. Dalli J, Winkler JW, Colas RA, Arnardottir H, Cheng C-YC, Chiang N, Petasis NA and Serhan CN (2013). Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Potent Immunoresolvents. Elsevier Cell Chemical Biology vol. 20, (2) 188-201. Sampaio ALF, Dalli J, Brancaleone V, D'Acquisto F, Perretti M and Wheatley C (2013). Biphasic modulation of NOS expression, protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock: downstream regulation of COX-2, IL-1β, TNF-α, IL-6, and HMGB1 expression. Mediators Inflamm vol. 2013, Dalli J, Colas RA and Serhan CN (2013). Novel n-3 Immunoresolvents: Structures and Actions. Springer Nature Scientific Reports vol. 3, (1) 2012
Jones CN, Dalli J, Dimisko L, Wong E, Serhan CN and Irimia D (2012). Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 109, (50) 20560-20565. Clària J, Dalli J, Yacoubian S, Gao F and Serhan CN (2012). Resolvin D1 and Resolvin D2 Govern Local Inflammatory Tone in Obese Fat. The American Association of Immunologists The Journal of Immunology vol. 189, (5) 2597-2605. Dalli J and Serhan CN (2012). Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators. American Society of Hematology Blood vol. 120, (15) e60-e72. Norling LV, Dalli J, Flower RJ, Serhan CN and Perretti M (2012). Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler Thromb Vasc Biol vol. 32, (8) 1970-1978. Giera M, Ioan-Facsinay A, Toes R, Gao F, Dalli J, Deelder AM, Serhan CN and Mayboroda OA (2012). Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC–MS/MS. Elsevier Biochimica et Biophysica Acta vol. 1821, (11) 1415-1424. Chen X, Barozzi I, Termanini A, Prosperini E, Recchiuti A, Dalli J, Mietton F, Matteoli G, Hiebert S and Natoli G (2012). Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 109, (42) e2865-e2874. Serhan CN, Dalli J, Karamnov S, Choi A, Park C, Xu Z, Ji R, Zhu M and Petasis NA (2012). Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. Wiley The FASEB Journal vol. 26, (4) 1755-1765. Dalli J, Jones CP, Cavalcanti DM, Farsky SH, Perretti M and Rankin SM (2012). Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow. FASEB J vol. 26, (1) 387-396. Dalli J, Montero-Melendez T, McArthur S and Perretti M (2012). Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils. Front Pharmacol vol. 3, Cardini S, Dalli J, Fineschi S, Perretti M, Lungarella G and Lucattelli M (2012). Genetic Ablation of the Fpr1 Gene Confers Protection from Smoking-Induced Lung Emphysema in Mice. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY vol. 47, (3) 332-339. Fredman G, Li Y, Dalli J, Chiang N and Serhan CN (2012). Self-Limited versus Delayed Resolution of Acute Inflammation: Temporal Regulation of Pro-Resolving Mediators and MicroRNA. Springer Nature Scientific Reports vol. 2, (1) 2011
Brancaleone V, Dalli J, Bena S, Flower RJ, Cirino G and Perretti M (2011). Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature. J Immunol vol. 186, (8) 4905-4914. Dufton N, Hannon R, Brancaleone V, Dalli J, Patel HB, Gray M, D'Acquisto F, Buckingham JC, Perretti M and Flower RJ (2011). Corrections: Anti-Inflammatory Role of the Murine Formyl-Peptide Receptor 2: Ligand-Specific Effects on Leukocyte Responses and Experimental Inflammation. The American Association of Immunologists The Journal of Immunology vol. 186, (4) 2684-2685. Brown SM, Dalli J, Perretti M, Bush A, Davies JC and Lloyd CM (2011). THE INFLAMMATORY RESOLUTION PROTEIN ANNEXIN A1 AND THE PAEDIATRIC CF AIRWAY. PEDIATRIC PULMONOLOGY 265-266. 2010
Pederzoli-Ribeil M, Maione F, Cooper D, Al-Kashi A, Dalli J, Perretti M and D'Acquisto F (2010). Design and characterization of a cleavage-resistant Annexin A1 mutant to control inflammation in the microvasculature. Blood vol. 116, (20) 4288-4296. Maderna P, Cottell DC, Toivonen T, Dufton N, Dalli J, Perretti M and Godson C (2010). FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis. FASEB J vol. 24, (11) 4240-4249. Renshaw D, Montero-Melendez T, Dalli J, Kamal A, Brancaleone V, D'Acquisto F, Cirino G and Perretti M (2010). Downstream gene activation of the receptor ALX by the agonist annexin A1. PLoS One vol. 5, (9) Dalli J, Rosignoli G, Hayhoe RPG, Edelman A and Perretti M (2010). CFTR inhibition provokes an inflammatory response associated with an imbalance of the annexin A1 pathway. Am J Pathol vol. 177, (1) 176-186. Dalli J, Rosignoli G, Hayhoe RPG, Edelman A and Perretti M (2010). CFTR Inhibition Provokes an Inflammatory Response Associated with an Imbalance of the Annexin A1 Pathway. AM J PATHOL vol. 177, (1) 176-186. Norling LV, Dalli J, Flower RJ, Serhan CN and Perretti M (2010). Resolvin D1 limits PMN recruitment to inflammatory loci: receptor dependent bioactions. FASEB JOURNAL vol. 24, Dufton N, Hannon R, Brancaleone V, Dalli J, Patel HB, Gray M, D'Acquisto F, Buckingham JC, Perretti M and Flower RJ (2010). Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. J Immunol vol. 184, (5) 2611-2619. 2009
Perretti M and Dalli J (2009). Exploiting the Annexin A1 pathway for the development of novel anti-inflammatory therapeutics. Br J Pharmacol vol. 158, (4) 936-946. Gastardelo TS, Damazo AS, Dalli J, Flower RJ, Perretti M and Oliani SM (2009). Functional and Ultrastructural Analysis of Annexin A1 and Its Receptor in Extravasating Neutrophils during Acute Inflammation. AM J PATHOL vol. 174, (1) 177-183. 2008
Dalli J, Norling LV, Renshaw D, Cooper D, Leung KY and Perretti M (2008). Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. BLOOD vol. 112, (6) 2512-2519. 2007
Gavins FNE, Dalli J, Flower RJ, Granger DN and Perretti M (2007). Activation of the annexin 1 counter-regulatory circuit affords protection in the mouse brain microcirculation. FASEB J vol. 21, (8) 1751-1758. Grants
Exploring the potential utility of SPM in regulating phagocyte responses to limit inflammation in MIJesmond Dalli
£66,955 Barts and the London Charity (01-01-2024 - 31-12-2024)
Replacement of protective activities of material provided by Lonza (1), (2) and (3)Jesmond Dalli
£213,967 Lonza Greenwood LLC (01-12-2022 - 31-12-2029)
Specialized Pro-resolving Mediators in HaematopoiesisJesmond Dalli and Antal Rot
£337,713 Barts and the London Charity (01-05-2022 - 30-04-2025)
Identification and quantitation of lipid mediators in media from cell incubations and in oilsJesmond Dalli
£42,022 WHRL William Harvey Research Limited (11-03-2024 - 10-09-2024)
Analysis of lipid mediator profiling datasetsJesmond Dalli
£7,555 WHRL William Harvey Research Limited (01-02-2024 - 31-07-2024)
Early detection of OPSCC through Salivary Specialized Lipid Mediator ProfilingJesmond Dalli
£65,100 Barts and the London Charity (01-10-2023 - 30-09-2024)
Establishing human organ-chip models for the bone marrowJesmond Dalli
£10,020 Animal Free Research UK (01-03-2023 - 09-07-2024)
Analysis of SPM in oilsJesmond Dalli
£15,634 WHRL William Harvey Research Limited (21-11-2022 - 20-11-2023)
Lipid Mediator Profiling In Arthritic Patients Following Splenic Stimulation -Scotland StudyJesmond Dalli
£23,738 Galvani Galvani Bioelectronics Limited (01-09-2022 - 31-12-2023)
Lipid mediator profiling in arthritic patients following splenic stimulation -US studyJesmond Dalli
£167,168 Galvani Galvani Bioelectronics Limited (01-09-2022 - 31-12-2023)
Specialised lipid mediator profiling during androgen deprivation therapy for prostate cancerJesmond Dalli
£10,000 WHRF William Harvey Research Foundation (01-11-2021 - 31-12-2023)
Analysis of lipid mediatorJesmond Dalli
£23,644 WHRL William Harvey Research Limited (05-07-2021 - 04-07-2023)
Joint Protective Actions of Omega-3 Derived Lipid MediatorsLucy Norling and Jesmond Dalli
£231,527 Barts and the London Charity (17-04-2021 - 30-11-2023)
Lipid Mediator Profling AZ - 300 samplesJesmond Dalli
£139,039 AZ AstraZeneca UK Limited (01-09-2019 - 29-02-2024)
Plasma Lipid Mediator Profiling - Fresenius KabiJesmond Dalli
£26,972 Fresenius Kabi (06-01-2019 - 31-12-2020)
Vagal Regulation of RvDn-3 DPA in Cardiovascular Protection during Inflammatory ArthritisJesmond Dalli
£219,163 Barts and the London Charity (01-09-2018 - 28-08-2022)
Statin triggered novel resolvins as innovative resolution based therapeutics in arthritisJesmond Dalli
£1,043,548 Wellcome Trust (07-09-2015 - 20-04-2021)