Prof Julien Gautrot
Professor of Biomaterials and Biointerfaces
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
Hydrogels, Microfabrication, 3D Printing, Mechanosensing, Microvascularisation, Bone marrow models
Interests
My lab is interested in the engineering of the cell microenvironment for advanced in vitro models and regenerative medicine applications. We design hydrogels with controlled biochemistry, mechanics, degradability and microstructure, allowing the regulation of stem cell phenotype (maintenance, differentiation, secretory phenotype). The biomaterials we engineer are also 3D printable and enable microfabrication (e.g. embedding in microfluidic chips or via photopatterning). We have a particular interest in microvascular models and their application to cancer, brain, cardiac and skin models, in collaboration with partners from the medical school.Publications
Publications of specific relevance to Predictive in vitro Models2024
Murphy JF, Lavelle M, Asciak L, Burdis R, Levis HJ, Ligorio C, McGuire J, Polleres M, Smith PO, Tullie L, Uribe-Gomez J, Chen B, Dawson JI, Gautrot JE, Hooper NM, Kelly DJ, Li VSW, Mata A, Pandit A, Phillips JB, Shu W, Stevens MM, Williams RL, Armstrong JPK and Huang YYS (2024). Biofabrication and biomanufacturing in Ireland and the UK. Springer Nature Bio-Design and Manufacturing 1-32. Zhang J, Marciano D, Wang L, Wang W, Gossen M, Yang M, Peng T, Gautrot J, Xu X and Ma N (2024). Bioinspired Hyaluronic Acid‐Based Hydrogel Fuels Bi‐Directional Lung Organoid Maturation via PIEZO1 and ITGB1 Mediated Mechanosensation. Wiley Advanced Materials Interfaces Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Manchanda R, Annibaldi A, Hopkins S, Garrobo-Calleja I, Gautrot J and Balkwill FR (2024). Human 3D Ovarian Cancer Models Reveal Malignant Cell-Intrinsic and -Extrinsic Factors That Influence CAR T-cell Activity. Cancer Res vol. 84, (15) 2432-2449. Marchena MH, Lambert E, Bogdanović B, Quadir F, Neri-Cruz CE, Luo J, Nadal C, Migliorini E and Gautrot JE (2024). BMP-Binding Polysulfonate Brushes to Control Growth Factor Presentation and Regulate Matrix Remodelling. American Chemical Society (ACS) ACS Applied Materials & Interfaces vol. 16, (31) 40455-40468. Mojares E, Nadal C, Hayler D, Kanso H, Chrysanthou A, Cruz CEN and Gautrot JE (2024). Strong Elastic Protein Nanosheets Enable the Culture and Differentiation of Induced Pluripotent Stem Cells on Microdroplets. Wiley Advanced Materials vol. 36, (38) Chrysanthou A, Bosch-Fortea M, Nadal C, Zarbakhsh A and Gautrot JE (2024). Interfacial mechanics of β-casein and albumin mixed protein assemblies at liquid-liquid interfaces. Elsevier Journal of Colloid and Interface Science vol. 674, 379-391. Summan S, Mayes A, Gunn D, Madapura P, Gautrot J, Caley M and O’Toole E (2024). O08 Exploring the effect of skin ageing-related basement membrane collagen loss on nuclear mechanics. Oxford University Press (OUP) British Journal of Dermatology vol. 190, (6) e71-e72. Joy JD, Malacrida B, Laforets F, Kotantaki P, Maniati E, Manchanda R, Hopkins S, Garrobo-Calleja I, Annibaldi A, Gautrot J and Balkwill FR (2024). Abstract B079: Human 3D ovarian cancer models reveal malignant cell intrinsic and extrinsic factors that influence CAR-T cell activity. American Association for Cancer Research (AACR) Cancer Research vol. 84, (5_Supplement_2) b079-b079. 
Di Cio S, Marhuenda E, Haddrick M and Gautrot JE (2024). Vascularised cardiac spheroids-on-a-chip for testing the toxicity of therapeutics. Springer Nature Scientific Reports vol. 14, (1) Scemama A, Lunetto S, Tailor A, Di Cio S, Dibble M, Gautrot J and Biddle A (2024). Development of an in vitro microfluidic model to study the role of microenvironmental cells in oral cancer metastasis. F1000Research F1000Research vol. 12, 2023
Summan SK, Mayes A, Gunn D, Gautrot J, Caley M and O’Toole E (2023). P16 How does skin ageing-related basement membrane collagen loss affect the nucleus? Oxford University Press (OUP) British Journal of Dermatology vol. 189, (1) e20-e20. Neri-Cruz CE, Teixeira FME and Gautrot JE (2023). A guide to functionalisation and bioconjugation strategies to surface-initiated polymer brushes. Royal Society of Chemistry Chemical Communications vol. 59, (49) 7534-7558. Summan SK, Mayes A, Gunn DA, Gautrot J, Caley M and O'Toole E (2023). 741 The effect of skin ageing-related basement membrane collagen loss on the nucleus. Elsevier Journal of Investigative Dermatology vol. 143, (5) s127-s127. Scemama A, Tailor A, Di Cio S, Dibble M, Gautrot J and Biddle A (2023). Development of an in vitro microfluidic model to study the role of microenvironmental cells in oral cancer metastasis. Taylor and Francis F1000Research vol. 12, 439-439. Cervantes-Salguero K, Gutiérrez Fosado YA, Megone W, Gautrot JE and Palma M (2023). Programmed Self-Assembly of DNA Nanosheets with Discrete Single-Molecule Thickness and Interfacial Mechanics: Design, Simulation, and Characterization. MDPI Molecules vol. 28, (9) Dibble M, Di Cio’ S, Luo P, Balkwill F and Gautrot JE (2023). The impact of pericytes on the stability of microvascular networks in response to nanoparticles. Springer Nature Scientific Reports vol. 13, (1) Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Garrobo-Calleja I, Gautrot J and Balkwill F (2023). Abstract 4576: 3D in vitro models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancer. American Association for Cancer Research (AACR) Cancer Research vol. 83, (7_Supplement) 4576-4576. Peng L, Nadal C and Gautrot JE (2023). Growth of mesenchymal stem cells at the surface of silicone, mineral and plant-based oils. IOP Publishing Biomedical Materials vol. 18, (3) Peng L, Matellan C, Bosch‐Fortea M, Gonzalez‐Molina J, Frigerio M, Salentinig S, del Rio Hernandez A and Gautrot JE (2023). Mesenchymal Stem Cells Sense the Toughness of Nanomaterials and Interfaces. Wiley Advanced Healthcare Materials vol. 12, (13) Nguyen KDQ, Dejean S, Nottelet B and Gautrot JE (2023). Mechanical Evaluation of Hydrogel–Elastomer Interfaces Generated through Thiol–Ene Coupling. American Chemical Society (ACS) ACS Applied Polymer Materials vol. 5, (2) 1364-1373. Chrysanthou A, Bosch-Fortea M and Gautrot JE (2023). Co-Surfactant-Free Bioactive Protein Nanosheets for the Stabilization of Bioemulsions Enabling Adherent Cell Expansion. American Chemical Society (ACS) Biomacromolecules vol. 24, (10) 4465-4477. Chrysanthou A, Kanso H, Zhong W, Shang L and Gautrot JE (2023). Supercharged Protein Nanosheets for Cell Expansion on Bioemulsions. American Chemical Society (ACS) ACS Applied Materials & Interfaces vol. 15, (2) 2760-2770. Kaur A, Gautrot JE, Akutagawa K, Watson D, Bickley A and Busfield JJC (2023). Thiyl radical induced cis / trans isomerism in double bond containing elastomers. Royal Society of Chemistry (RSC) RSC Advances vol. 13, (34) 23967-23975. 2022
Kaur A, Gautrot JE, Cavalli G, Watson D, Bickley A, Akutagawa K and Busfield JJC (2022). Kinetic analysis of thiol-ene based cross-linking reaction of polychloroprene rubber. Constitutive Models for Rubber XII Taylor & Francis Gautrot JE, Chang L, Alexis C, Gutfreund P and Zarbakhsh A (2022). The Architecture of Oligonucleotide-Polycationic Brush Complexes – A Neutron Reflectometry Study. Wiley Advanced Materials Interfaces Jones CFE, Di Cio S, Connelly JT and Gautrot JE (2022). Design of an Integrated Microvascularized Human Skin-on-a-Chip Tissue Equivalent Model. Frontiers Media Frontiers in Bioengineering and Biotechnology vol. 10, Sarmin AM, Moussaid NE, Suntornnond R, Tyler EJ, Kim Y-H, Di Cio S, Megone WV, Pearce O, Gautrot JE, Dawson J and Connelly JT (2022). Multi-Scale Analysis of the Composition, Structure, and Function of Decellularized Extracellular Matrix for Human Skin and Wound Healing Models. MDPI Biomolecules vol. 12, (6) Ghorbani S, Shahrokhtash A, Gautrot JE and Sutherland DS (2022). Protein Ligand Nanopattern Size Selects for Cellular Adhesion via Hemidesmosomes over Focal Adhesions. Wiley Small Methods vol. 6, (6) Kong D, Peng L, Bosch-Fortea M, Chrysanthou A, Alexis CVJM, Matellan C, Zarbakhsh A, Mastroianni G, del Rio Hernandez A and Gautrot JE (2022). Impact of the multiscale viscoelasticity of quasi-2D self-assembled protein networks on stem cell expansion at liquid interfaces. Elsevier Biomaterials vol. 284, Nguyen NT, Jennings J, Milani AH, Martino CDS, Nguyen LTB, Wu S, Mokhtar MZ, Saunders JM, Gautrot JE, Armes SP and Saunders BR (2022). Highly Stretchable Conductive Covalent Coacervate Gels for Electronic Skin. American Chemical Society (ACS) Biomacromolecules vol. 23, (3) 1423-1432. 2021
Peng L and Gautrot JE (2021). Long term expansion profile of mesenchymal stromal cells at protein nanosheet-stabilised bioemulsions for next generation cell culture microcarriers. Elsevier Materials Today Bio vol. 12, 100159-100159. Raynold AAM, Li D, Chang L and Gautrot JE (2021). Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors. Springer Nature Nature Communications vol. 12, (1) Nguyen KDQ, Crespo-Ribadeneyra M, Picot O, Colak B and Gautrot JE (2021). Ultrafast Photo-Crosslinking of Thiol–Norbornene Opaque Silicone Elastomer Nanocomposites in Air. American Chemical Society ACS Applied Polymer Materials Kaur A, Gautrot JE, Cavalli G, Watson D, Bickley A, Akutagawa K and Busfield JJC (2021). Novel Crosslinking System for Poly-Chloroprene Rubber to Enable Recyclability and Introduce Self-Healing. MDPI Polymers vol. 13, (19) Megone W, Tang P, Roohpour N and Gautrot JE (2021). Impact of the molecular structure of cationic binders on the rheological and adhesive properties of carboxymethyl cellulose-based coacervate hydrogels. ARKAT USA Arkivoc vol. 2021, (6) 101-119. Chang L, Yan H, Chang J and Gautrot JE (2021). Cationic Polymer Brush-Coated Bioglass Nanoparticles for the Design of Bioresorbable RNA Delivery Vectors. Elsevier European Polymer Journal 110593-110593. Pang X, Li W, Chang L, Gautrot JE, Wang W and Azevedo HS (2021). Hyaluronan (HA) Immobilized on Surfaces via Self-Assembled Monolayers of HA-Binding Peptide Modulates Endothelial Cell Spreading and Migration through Focal Adhesion. American Chemical Society ACS Applied Materials and Interfaces vol. 13, (22) 25792-25804. Megone W, Kong D, Peng L and Gautrot JE (2021). Extreme reversal in mechanical anisotropy in liquid-liquid interfaces reinforced with self-assembled protein nanosheets. Elsevier Journal of Colloid and Interface Science vol. 594, 650-657. Qu F, Ma X and Gautrot JE (2021). Precise positioning of enzymes within hierarchical polymer nanostructures for switchable bioelectrocatalysis. Elsevier Biosensors and Bioelectronics vol. 179, 113045-113045. Cozens EJ, Roohpour N and Gautrot JE (2021). Comparative Adhesion of Chemically and Physically Crosslinked Poly(Acrylic Acid)-Based Hydrogels to Soft Tissues. Elsevier European Polymer Journal 110250-110250. Qu F, Raynold AM and Gautrot JE (2021). Chapter 11 Recent Advances in the Design of Surface-initiated Polymer Brushes for Biomedical Applications. Soft Matter for Biomedical Applications Royal Society of Chemistry (RSC) 2020
Zhang X, Shi X, Gautrot JE and Peijs T (2020). Nanoengineered electrospun fibers and their biomedical applications: a review. Taylor & Francis Nanocomposites vol. 7, (1) 1-34. Suzuki K and Gautrot J (2020). Engineered Cell-Degradable Poly(2-alkyl-2-oxazoline) Hydrogels Improve Epicardial Placement of Mesenchymal Stromal Cells by Stimulating Paracrine Signaling for Cardiac Repair. Elsevier Biomaterials You Y, Kobayashi K, Colak B, Luo P, Cozen E, Fields L, Suzuki K and Gautrot J (2020). Engineered cell-degradable poly(2-alkyl-2-oxazoline) hydrogel for epicardial placement of mesenchymal stem cells for myocardial repair. Elsevier Biomaterials 120356-120356. Li D, Xu L, Wang J and Gautrot JE (2020). Responsive Polymer Brush Design and Emerging Applications for Nanotheranostics. Wiley Advanced Healthcare Materials Colak B, Wu L, Cozens EJ and Gautrot JE (2020). Modulation of Thiol-Ene Coupling by the Molecular Environment of Polymer Backbones for Hydrogel Formation and Cell Encapsulation. American Chemical Society ACS Applied Bio Materials Wu L, Di Cio S, Azevedo HS and Gautrot JE (2020). Photoconfigurable, Cell-Remodelable Disulfide Cross-linked Hyaluronic Acid Hydrogels. American Chemical Society Biomacromolecules Zhang X, Megone W, Peijs T and Gautrot JE (2020). Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites. Taylor & Francis Group Nanocomposites 2019
Di Cio S, Iskratsch T, Connelly JT and Gautrot JE (2019). Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing. Elsevier Biomaterials vol. 232, Cozens EJ, Kong D, Roohpour N and Gautrot JE (2019). The physico-chemistry of adhesions of protein resistant and weak polyelectrolyte brushes to cells and tissues. Royal Society of Chemistry Soft Matter vol. 16, (2) 505-522. Li D, Wu L, Qu F, Ribadeneyra MC, Tu G and Gautrot J (2019). Core-independent approach for polymer brush-functionalised nanomaterials with a fluorescent tag for RNA delivery. Royal Society of Chemistry Chemical Communications vol. 55, (94) 14166-14169. Ahmad N, Colak B, Gibbs MJ, Zhang D-W, Gautrot JE, Watkinson M, Becer CR and Krause S (2019). Peptide Cross-Linked Poly(2-oxazoline) as a Sensor Material for the Detection of Proteases with a Quartz Crystal Microbalance. Biomacromolecules vol. 20, (7) 2506-2514. Crespo M, Santagiuliana G, Picot O, Portale G, Bilotti E and Gautrot JE (2019). Photo‐Responsive Graphene: A Photoaddressable Liquid Crystalline Phase Transition in Graphene Oxide Nanocomposites (Adv. Funct. Mater. 24/2019). Wiley Advanced Functional Materials vol. 29, (24) Qu F, Li D, Ma X, Chen F and Gautrot JE (2019). A Kinetic Model of Oligonucleotide–Brush Interactions for the Rational Design of Gene Delivery Vectors. American Chemical Society (ACS) Biomacromolecules vol. 20, (6) 2218-2229. Crespo M, Santagiuliana G, Picot O, Portale G, Bilotti E and Gautrot JE (2019). A Photoaddressable Liquid Crystalline Phase Transition in Graphene Oxide Nanocomposites. Wiley Advanced Functional Materials vol. 29, (24) Ahmad N, Colak B, Zhang D-W, Gibbs MJ, Watkinson M, Becer CR, Gautrot JE and Krause S (2019). Peptide Cross-Linked Poly (Ethylene Glycol) Hydrogel Films as Biosensor Coatings for the Detection of Collagenase. MDPI Sensors vol. 19, (7) GAUTROT JEE (2019). Conformational Dynamics and Responsiveness of Weak and Strong Polyelectrolyte Brushes: Atomistic Simulations of PDMAEMA and PMETAC. American Chemical Society Langmuir GAUTROT JEE (2019). Modes of adsorption of polyelectrolytes to model substrates of hydroxyapatite. Elsevier Journal of Colloid and Interface Science vol. 543, 237-237. 2018
Ahmad N, Colak B, Gibbs MJ, Zhang D-W, Becer CR, Watkinson M, Gautrot JE and Krause S (2018). Collagenase Biosensor Based on the Degradation of Peptide Cross-Linked Poly(Ethylene Glycol) Hydrogel Films. MDPI Kong D, Peng L, Di Cio S, Novak P and Gautrot JE (2018). Stem Cell Expansion and Fate Decision on Liquid Substrates Are Regulated by Self-Assembled Nanosheets. ACS Nano vol. 12, (9) 9206-9213. Zhang X, Geven MA, Wang X, Qin L, Grijpma DW, Peijs T, Eglin D, Guillaume O and Gautrot JE (2018). A drug eluting poly(trimethylene carbonate)/poly(lactic acid)-reinforced nanocomposite for the functional delivery of osteogenic molecules. Taylor & Francis International Journal of Nanomedicine vol. 13, 5701-5718. Tang P, di Cio S, Wang W and E Gautrot J (2018). Surface-Initiated Poly(oligo(2-alkyl-2-oxazoline)methacrylate) Brushes. Langmuir vol. 34, (34) 10019-10027. Zhang F, An Y, Roohpour N, Barber AH and Gautrot JE (2018). Hydration dependent mechanical performance of denture adhesive hydrogels. Elsevier Dental Materials vol. 34, (10) 1440-1448. Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T (2018). Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions. Elsevier Developmental Cell vol. 45, (5) Megone W, Roohpour N and Gautrot JE (2018). Impact of surface adhesion and sample heterogeneity on the multiscale mechanical characterisation of soft biomaterials. Sci Rep vol. 8, (1) 6780-6780. Mata A, Azevedo HS, Connelly J and Gautrot J (2018). Bioengineering Complexity and Tuneability in Hydrogels. Hydrogels Taylor & Francis Kong D, Megone W, Nguyen KDQ, Di Cio S, Ramstedt M and Gautrot JE (2018). Protein Nanosheet Mechanics Controls Cell Adhesion and Expansion on Low-Viscosity Liquids. Nano Lett Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T (2018). Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions. Dev Cell vol. 44, (3) 326-336.e3. Li D, Sharili AS, Connelly J and Gautrot JE (2018). Highly Stable RNA Capture by Dense Cationic Polymer Brushes for the Design of Cytocompatible, Serum-Stable SiRNA Delivery Vectors. Biomacromolecules Gill SK, Roohpour N, An Y, Gautrot JE, Topham PD and Tighe BJ (2018). Hydrophobic and hydrophilic effects on water structuring and adhesion in denture adhesives. Wiley Journal of Biomedical Materials Research Part A vol. 106, (5) 1355-1362. Colak B, Di Cio S and Gautrot JE (2018). Biofunctionalised Patterned Polymer Brushes via Thiol-Ene Coupling for the Control of Cell Adhesion and the Formation of Cell Arrays. Biomacromolecules 2017
Li D and Gautrot JE (2017). Design of Polymer Brushes for Cell Culture and Cellular Delivery. Polymer and Biopolymer Brushes Wiley Krishnamoorthy M, Li D, Sharili AS, Gulin-Sarfraz T, Rosenholm JM and Gautrot JE (2017). The Solution Conformation of Polymer Brushes Determines their Interactions with DNA and Transfection Efficiency. Biomacromolecules Darshan GH, Kong D, Gautrot J and Vootla S (2017). Physico-chemical characterization of Antheraea mylitta silk mats for wound healing applications. Springer Nature Scientific Reports vol. 7, (1) Zhang X, Geven MA, Grijpma D, Peijs T and Gautrot JE (2017). Tunable and processable shape memory composites based on degradable polymers. Polymer Kong D, Nguyen KDQ, Megone W, Peng L and Gautrot JE (2017). The culture of HaCaT cells on liquid substrates is mediated by a mechanically strong liquid–liquid interface. Faraday Discuss. vol. 204, 367-381. Di Cio S, Bøggild TML, Connelly J, Sutherland DS and Gautrot JE (2017). Differential integrin expression regulates cell sensing of the matrix nanoscale geometry. Acta Biomaterialia vol. 50, 280-292. Gh D, Kong D, Gautrot J and Vootla SK (2017). Fabrication and Characterization of Conductive Conjugated Polymer-Coated Antheraea mylitta Silk Fibroin Fibers for Biomedical Applications. Macromol Biosci vol. 17, (7) Amabilino D, Bâldea I, Barykina O, Batteas J, Besenius P, Beton P, Bilbao N, Buck M, Chi L, Clarke S, Costantini G, Davidson J, Davies P, De Feyter S, Diaz Fernandez Y, Dwivedi D, Ernst K-H, Flood A, Gautrot J, Jabbarzadeh A, Korolkov V, Kühnle A, Lackinger M, Pradier C-M, Rahman T, Raval R, Schwaminger S, Seibel J, Tait SL and Teyssandier J (2017). Preparing macromolecular systems on surfaces: general discussion. Royal Society of Chemistry (RSC) Faraday Discussions vol. 204, 395-418. 2016
Gautrot JE (2016). Cell Sensing of the Physical Properties of the Microenvironment at Multiple Scales. Mechanobiology Wiley Attwood SJ, Cortes E, Haining AW, Robinson B, Li D, Gautrot J and Del Río Hernández A (2016). Adhesive ligand tether length affects the size and length of focal adhesions and influences cell spreading and attachment. Sci Rep vol. 6, 34334-34334. Colak B, Da Silva JCS, Soares TA and Gautrot JE (2016). Impact of the Molecular Environment on Thiol-Ene Coupling For Biofunctionalization and Conjugation. American Chemical Society Bioconjugate Chemistry vol. 27, (9) 2111-2123. Nguyen KDQ, Megone WV, Kong D and Gautrot JE (2016). Ultrafast diffusion-controlled thiol-ene based crosslinking of silicone elastomers with tailored mechanical properties for biomedical applications. Polymer Chemistry vol. 7, (33) 5281-5293. Zhang X, Geven MA, Grijpma DW, Gautrot JE and Peijs T (2016). “Polymer-polymer composites for the design of strong and tough degradable biomaterials”. Materials Today Communications vol. 8, 53-63. An Y, Li D, Roohpour N, Gautrot JE and Barber AH (2016). Failure mechanisms in denture adhesives. Elsevier Dental Materials vol. 32, (5) 615-623. Di Cio S and Gautrot JE (2016). Cell sensing of physical properties at the nanoscale: Mechanisms and control of cell adhesion and phenotype. Acta Biomaterialia vol. 30, 26-48. Tan KY, Ramstedt M, Colak B, Huck WTS and Gautrot JE (2016). Study of thiol–ene chemistry on polymer brushes and application to surface patterning and protein adsorption. Royal Society of Chemistry (RSC) Polymer Chemistry vol. 7, (4) 979-990. 2015
Di Cio S and Gautrot JE (2015). Cell sensing of physical properties at the nanoscale: Mechanisms and control of cell adhesion and phenotype. Elsevier Acta Biomaterialia vol. 30, 26-48. Eglin D, Alini M, de Bruijn J, Gautrot J, Grijpma DW, Kamer L, Lai Y, Lu S, Peijs T, Peng J, Tang TT, Wang X, Richards RG and Qin L (2015). The RAPIDOS project-European and Chinese collaborative research on biomaterials. J Orthop Translat vol. 3, (2) 78-84. Hackett AJ, Malmström J, Molino PJ, Gautrot JE, Zhang H, Higgins MJ, Wallace GG, Williams DE and Travas-Sejdic J (2015). Conductive surfaces with dynamic switching in response to temperature and salt. Royal Society of Chemistry (RSC) Journal of Materials Chemistry B vol. 3, (48) 9285-9294. 2014
Wang J, Zhou Y, Watkinson M, Gautrot J and Krause S (2014). High-sensitivity light-addressable potentiometric sensors using silicon on sapphire functionalized with self-assembled organic monolayers. Elsevier Sensors and Actuators B: Chemical vol. 209, 230-236. Krishnamoorthy M, Hakobyan S, Ramstedt M and GAUTROT JEE (2014). Surface initiated polymer brushes in the biomedical field: Applications in membrane science, biosensing, cell culture, regenerative medicine and antibacterial coatings. American Chemical Society Chemical Reviews vol. 114, (21) 10976-11026. Deo DI, Gautrot JE, Sukhorukov GB and Wang W (2014). Biofunctionalization of PEGylated microcapsules for exclusive binding to protein substrates. Biomacromolecules vol. 15, (7) 2555-2562. Gautrot JE, Malmström J, Sundh M, Margadant C, Sonnenberg A and Sutherland DS (2014). The nanoscale geometrical maturation of focal adhesions controls stem cell differentiation and mechanotransduction. Nano Letters vol. 14, (7) 3945-3952. Costa P, Gautrot JE and Connelly JT (2014). Directing cell migration using micropatterned and dynamically adhesive polymer brushes. Acta Biomater vol. 10, (6) 2415-2422. 2013
Tan KY, Lin H, Ramstedt M, Watt FM, Huck WTS and Gautrot JE (2013). Decoupling geometrical and chemical cues directing epidermal stem cell fate on polymer brush-based cell micro-patterns. Integr Biol (Camb) vol. 5, (6) 899-910. GAUTROT JEE, Rzhepishevska O, Hakobyan S, Ruhal R, Barbero D and Ramstedt M (2013). The surface charge of anti-bacterial coatings alters motility and biofilm architecture. Journal of Biomaterials Science: Polymer Edition vol. 1, (6) 589-602. 2012
Gautrot JE, Wang C, Liu X, Goldie SJ, Trappmann B, Huck WTS and Watt FM (2012). Mimicking normal tissue architecture and perturbation in cancer with engineered micro-epidermis. Biomaterials vol. 33, (21) 5221-5229. Trappmann B, Gautrot JE, Connelly JT, Strange DGT, Li Y, Oyen ML, Cohen Stuart MA, Boehm H, Li B, Vogel V, Spatz JP, Watt FM and Huck WTS (2012). Extracellular-matrix tethering regulates stem-cell fate. Nature Materials 2011
Rodriguez-Emmenegger C, Brynda E, Riedel T, Houska M, Šubr V, Alles AB, Hasan E, Gautrot JE and Huck WTS (2011). Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces. Macromol Rapid Commun vol. 32, (13) 952-957. Tan KY, Gautrot JE and Huck WTS (2011). Formation of pickering emulsions using ion-specific responsive colloids. Langmuir vol. 27, (4) 1251-1259. Connelly JT, Mishra A, Gautrot JE and Watt FM (2011). Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation. PLoS One vol. 6, (11) Tan KY, Gautrot JE and Huck WTS (2011). Island brushes to control adhesion of water in oil droplets on planar surfaces. SOFT MATTER vol. 7, (15) 7013-7020. Strandman S, Gautrot JE and Zhu XX (2011). Recent advances in entropy-driven ring-opening polymerizations. POLYMER CHEMISTRY vol. 2, (4) 791-799. 2010
Connelly JT, Gautrot JE, Trappmann B, Tan DWM, Donati G, Huck WTS and Watt FM (2010). Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nature Cell Biology vol. 12, (7) 711-718. Gautrot JE, Trappmann B, Oceguera-Yanez F, Connelly J, He X, Watt FM and Huck WTS (2010). Exploiting the superior protein resistance of polymer brushes to control single cell adhesion and polarisation at the micron scale. Biomaterials vol. 31, (18) 5030-5041. Gautrot JE, Huck WTS, Welch M and Ramstedt M (2010). Protein-resistant NTA-functionalized polymer brushes for selective and stable immobilization of histidine-tagged proteins. ACS Appl Mater Interfaces vol. 2, (1) 193-202. Therien-Aubin H, Gautrot JE, Shao Y, Zhang J and Zhu XX (2010). Shape memory properties of main chain bile acids polymers. POLYMER vol. 51, (1) 22-25. 2009
Gautrot JE and Zhu XX (2009). Shape memory polymers based on naturally-occurring bile acids. Macromolecules vol. 42, (19) 7324-7331. Trmcic-Cvitas J, Hasan E, Ramstedt M, Li X, Cooper MA, Abell C, Huck WTS and Gautrot JE (2009). Biofunctionalized protein resistant oligo(ethylene glycol)-derived polymer brushes as selective immobilization and sensing platforms. Biomacromolecules vol. 10, (10) 2885-2894. Gautrot JE and Zhu XX (2009). Macrocyclic bile acids: from molecular recognition to degradable biomaterial building blocks. JOURNAL OF MATERIALS CHEMISTRY vol. 19, (32) 5705-5716. Huck WTS, Gautrot J and Watt F (2009). The effects of surface chemistry on epidermal stem cell differentiation. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY vol. 237, Hodge P and Gautrot JE (2009). Polymers containing in-chain quinone moieties: synthesis and properties. POLYMER INTERNATIONAL vol. 58, (3) 261-266. Gautrot JE, Zhang J, Shao Y and Zhu XX (2009). New degradable polymers made from natural compounds bile acids by ROMP. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY vol. 237, Gautrot JE, Hodge P, Helliwell M, Raftery J and Cupertino D (2009). Synthesis of electron-accepting polymers containing phenanthra-9,10-quinone units. JOURNAL OF MATERIALS CHEMISTRY vol. 19, (24) 4148-4156. 2008
Gautrot JE and Zhu XX (2008). High molecular weight bile acid and ricinoleic acid-based copolyesters via entropy-driven ring-opening metathesis polymerisation. Chem Commun (Camb) (14) 1674-1676. 2007
Nguyen BT, Gautrot JE, Nguyen MT and Zhu XX (2007). Silver nanoparticles stabilized by nitrocellulose as low conversion temperature precursors for inkjet-printed electronic circuits. 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings vol. 2, 68-71. Charbonneau C, Gautrot JE, Hébert M-J, Zhu XX and Lerouge S (2007). Chondroitin-4-sulfate: a bioactive macromolecule to foster vascular healing around stent-grafts after endovascular aneurysm repair. Macromol Biosci vol. 7, (5) 746-752. Chen Y, Gautrot JE and Zhu XX (2007). Synthesis and characterization of core-shell microspheres with double thermosensitivity. Langmuir vol. 23, (3) 1047-1051. Gautrot JE and Zhu XX (2007). Molar mass of main-chain bile acid-based oligo-esters measured by SEC, MALDI-TOF spectrometry and NMR spectroscopy: a comparative study. Anal Chim Acta vol. 581, (2) 281-286. Gautrot JE, Hodge P, Cupertino D and Helliwell M (2007). 2,6-Diaryl-9,10-anthraquinones as models for electron-accepting polymers. NEW JOURNAL OF CHEMISTRY vol. 31, (9) 1585-1593. Chen Y, Gautrot JE and Zhu XX (2007). Synthesis and characterization of core-shell microspheres with double thermosensitivity. LANGMUIR vol. 23, (3) 1047-1051. Chen Y, Gautrot JE, Li Z and Zhu XX (2007). Preparation and thermo-responsive light diffraction behaviors of soft polymerized crystalline colloidal arrays. SOFT MATTER vol. 3, (5) 571-579. Nguyen BT, Gautrot JE, Nguyen MT and Zhu XX (2007). Nitrocellulose-stabilized silver nanoparticles as low conversion temperature precursors useful for inkjet printed electronics. JOURNAL OF MATERIALS CHEMISTRY vol. 17, (17) 1725-1730. Gautrot JE and Hodge P (2007). Poly(dibenzo[a,c]phenazine-2,7-diyl)s -: Synthesis and characterisation of a new family of electron-accepting conjugated polymers. POLYMER vol. 48, (24) 7065-7077. 2006
Gautrot JE and Zhu XX (2006). Main-chain bile acid based degradable elastomers synthesized by entropy-driven ring-opening metathesis polymerization. Angew Chem Int Ed Engl vol. 45, (41) 6872-6874. Gautrot JE and Zhu XX (2006). Main‐Chain Bile Acid Based Degradable Elastomers Synthesized by Entropy‐Driven Ring‐Opening Metathesis Polymerization. Wiley Angewandte Chemie vol. 118, (41) 7026-7028. Nguyen BT, Gautrot JE, Ji C, Brunner P-L, Nguyen MT and Zhu XX (2006). Enhancing the photoluminescence intensity of conjugated polycationic polymers by using quantum dots as antiaggregation reagents. Langmuir vol. 22, (10) 4799-4803. Gautrot JE and Zhu XX (2006). Biodegradable polymers based on bile acids and potential biomedical applications. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION vol. 17, (10) 1123-1139. Gautrot JE, Hodge P, Cupertino D and Helliwell M (2006). Experimental evidence for carbonyl-π electron cloud interactions. NEW JOURNAL OF CHEMISTRY vol. 30, (12) 1801-1807. 2005
Schroeder R, Majewski LA, Grell M, Maunoury J, Gautrot J, Hodge P and Turner M (2005). Electrode specific electropolymerization of ethylenedioxythiophene: Injection enhancement in organic transistors. APPLIED PHYSICS LETTERS vol. 87, (11) Grants
Grants of specific relevance to Predictive in vitro ModelsUnravelling mechanisms of drug-induced myocarditis using immune-responsive human cardiovascular chipYung-Yao Lin and Julien Gautrot
£121,420 MRC Medical Research Council (01-10-2024 - 30-09-2028)
APP13387: Micro-manufacturing of tissue patterned organ-chips for accelerated deployment of new medicinesMartin Knight, Hazel Screen, Julien Gautrot, Timothy Hopkins, John Connelly, Liisa Blowes and Xavier Griffin
£1,787,725 EPSRC Engineering and Physical Sciences Research Council (01-07-2024 - 30-06-2027)
ProNaGen: Engineering of Recombinant Protein Nanosheet-Based Bioemulsions for Next Generation Bioprocessing and BiomanufacturingJulien Gautrot
£127,041 EPSRC - EU Scheme (01-11-2023 - 30-04-2025)
Targeting epigenetic gene regulation in epidermolysis bullosa simplexJohn Connelly, Julien Gautrot and David Kelsell
£199,751 Action Medical Research (01-06-2023 - 31-05-2026)
Engineered Recombinant Strategies to Organogel Design for Food Product FormulationsJulien Gautrot
£32,500 Motif Food Works Inc (01-09-2022 - 31-08-2026)
Costing of MoBioC mini-CDT studentship for bit.bio, 3M, Sphere Fluidics, RB, Unilever, Photocentric and Manchester BiogelJulien Gautrot
£70,000 Bit.Bio Ltd (01-09-2021 - 01-09-2025)