Dr Joash Joy
Post Doctoral Research Fellow
Barts Cancer Institute
Queen Mary University of London
Queen Mary University of London
Research
Organ-on-a-chip, CAR-T cells, Ovarian Cancer, 3D in vitro models
Interests
Developing and testing 3D in vitro multicellular models of ovarian cancer, including ovarian cancer-on-a-chip.Publications
Publications of specific relevance to Predictive <em>in vitro</em> Models2024
Abstract B079: Human 3D ovarian cancer models reveal malignant cell intrinsic and extrinsic factors that influence CAR-T cell activityJoy JD, Malacrida B, Laforets F, Kotantaki P, Maniati E, Manchanda R, Hopkins S, Garrobo-Calleja I, Annibaldi A, Gautrot J and Balkwill FR
Cancer Research, American Association For Cancer Research (Aacr) vol. 84 (5_Supplement_2), b079-b079.
04-03-2024
2023
Abstract 4576: 3D in vitro models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancerJoy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Garrobo-Calleja I, Gautrot J and Balkwill F
Cancer Research, American Association For Cancer Research (Aacr) vol. 83 (7_Supplement), 4576-4576.
04-04-2023
2022
Abstract 693: TGFβ-mediated targeting of the extracellular matrix enhances the migration and cytotoxicity of CAR-T cells in 3D models of ovarian cancerJoy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Calleja I, Brett S, Athanasopoulos T, Ali S, Emery-Billcliff P, Ricciardelli I, Kay C, Colebrook J, Ali M, Strong K and Balkwill F
Cancer Research, American Association For Cancer Research (Aacr) vol. 82 (12_Supplement), 693-693.
15-06-2022
2020
Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to TreatmentManiati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C, Delaine-Smith RM, Pearce OMT, Hirani P, Joy JD, Szabova L, Perets R, Sansom OJ, Drapkin R, Bailey P and Balkwill FR
Cell Reports, Elsevier vol. 30 (2), 525-540.e7.
01-01-2020