Dr Jordi Lopez-Tremoleda
Reader in Animal Science & Welfare / Names Veterinary Surgeonn and Welfare Officer at QMUL
Queen Mary University of London
Research
Refinements in vivo modelling, Lab animal Care & welfare, Preclinical testing, Brain injury modelling, Preclinical Imaging, Transition towards alternatives
Interests
Academic veterinarian with vast expertise on in vivo preclinical modeling and in vivo refinements. I have a great interest to support the development of innovative alternative approaches and, particularly, support training and education of in vivo researchers and technical staff to engage with in vitro modelling and engage with the development and validation of these in vitro technologies.Publications
2024
Tremoleda J, Jirkof P, Lang A and Sanchez-Morgado JM (2024). To our esteemed colleague J-P. SAGE Publications Laboratory Animals vol. 58, (6) 510-511. Tremoleda JL (2024). Our 61st Annual Meeting: An exciting programme is shaping up! SAGE Publications Laboratory Animals vol. 58, (5) 499-499. Al-Khateeb ZF, Boumenar H, Adebimpe J, Shekerzade S, Henson SM, Tremoleda JL and Michael-Titus AT (2024). The cellular senescence response and neuroinflammation in juvenile mice following controlled cortical impact and repetitive mild traumatic brain injury. Elsevier Experimental Neurology vol. 374, 2023
Simpson R, Praditsuktavorn B, Wall J, Morales V, Thiemermann C, Tremoleda JL and Brohi K (2023). Myocardial alterations following traumatic hemorrhagic injury. Wolters Kluwer Journal of Trauma and Acute Care Surgery vol. 95, (4) 481-489. Gains CC, Giannapoulos A, Zamboulis DE, Lopez-Tremoleda J and Screen HRC (2023). Development and application of a novel in vivo overload model of the Achilles tendon in rat. Elsevier Journal of Biomechanics vol. 151, Warner A, Law B and Tremoleda JL (2023). A successful return to in-person LASA Annual Conference 2022. SAGE Publications Laboratory Animals vol. 57, (1) 87-88. Tremoleda JL, Cederroth C and Jirkof P (2023). Engaging on discussions about the use and the replacement of animals in research with young minds. SAGE Publications Laboratory Animals vol. 57, (3) 221-223. 2022
Kirtland J, Tremoleda JL and Trivedy C (2022). Traumatic injury patterns in humans from large feline predators: A systematic review and descriptive analysis. SAGE Publications Trauma (London, England) vol. 26, (1) 28-42. Tremoleda JL (2022). Reducing the Number of Research Animals: How Imaging Technologies Can Help. Frontiers Frontiers for Young Minds vol. 10, Tremoleda JL, Kerton A, Mazhary H and Greenhough B (2022). New perspectives for teaching Culture of Care and their strengths and challenges. SAGE Publications Laboratory Animals vol. 57, (2) 170-181. Perez-Ternero C, Pallier PN, Tremoleda JL, Delogu A, Fernandes C, Michael-Titus AT and Hobbs AJ (2022). C-type natriuretic peptide preserves central neurological function by maintaining blood-brain barrier integrity. Frontiers Frontiers in Molecular Neuroscience vol. 15, Sánchez-Morgado JM, Jirkof P, Lang A, Mocho J-P and Tremoleda JL (2022). Is it time for a ‘Culture of Carers’? SAGE Publications Laboratory Animals vol. 56, (6) 498-498. Sánchez-Morgado JM, Whitfield L, Tremoleda JL, Mocho J-P, Lang A and Jirkof P (2022). How to publish a case report in Laboratory Animals? SAGE Publications Laboratory Animals vol. 57, (1) 2-2. Teoh L, Ihalage AA, Harp S, Al-Khateeb ZF, Michael-Titus AT, Tremoleda JL and Hao Y (2022). Deep learning for behaviour classification in a preclinical brain injury model. Public Library of Science (PLoS) PLOS ONE vol. 17, (6) Tremoleda JL and Law B (2022). Success for our first Virtual LASA Annual Conference. SAGE Publications Laboratory Animals vol. 56, (2) 201-203. Lang A, Jirkof P, Mocho J-P, Sanchez-Morgado J and Tremoleda JL (2022). Report from the 11th edition of the World Congress on Alternatives and Animal Use in the Life Sciences (WC11). SAGE Publications Laboratory Animals vol. 56, (1) 101-102. 2021
Osman M, Olkun A, Maldonado AM, Lopez‐Tremoleda J, Sanchez‐Perea N and Paredes UM (2021). Parentally deprived juvenile Owl monkeys suffer from long‐term high infection rates but not from altered hair cortisol concentrations nor from stereotypic behaviours. Wiley Journal of Medical Primatology vol. 50, (6) 306-312. Jirkof P, Lang A, Mocho J-P, Sanchez-Morgado J and Tremoleda JL (2021). Do you want to join our Editorial Board? SAGE Publications Laboratory Animals vol. 55, (3) 202-214. Thaventhiran A, Thiemermann C, Brohi K, Tremoleda J and Davenport R (2021). O1: DISCOVERING NOVEL THERAPEUTICS TO TREAT ACUTE TRAUMATIC COAGULOPATHY (ATC). Oxford University Press (OUP) British Journal of Surgery vol. 108, (Supplement_1) Jirkof P, Sanchez-Morgado J and Tremoleda JL (2021). News from the EIC team. SAGE Publications Laboratory Animals vol. 55, (2) 189-189. Kerton A and Tremoleda JL (2021). Emotional challenges in our work with laboratory animals: tools that support caring for others and yourself. Animal Technology and Welfare vol. 20, (1) 35-41. Jennings M, Berdoy M, Farmer AM, Hawkins P, Lilley E, Kerton A, Law B, Tremoleda JL, Stanford C, Whitfield L and Ryder K (2021). Guiding principles to help deliver the ethics learning outcomes of module 2 for personal licensees. Animal Technology and Welfare vol. 20, (1) 63-72. Tremoleda JL and Kerton A (2021). Teaching a culture of care: Why it matters. Edicions de la Universitat de Barcelona Revista de Bioética y Derecho (51) 43-60. Thau-Zuchman O, Svendsen L, Dyall SC, Paredes-Esquivel U, Rhodes M, Priestley JV, Feichtinger RG, Kofler B, Lotstra S, Martin Verkuyl J, Hageman RJ, Broersen LM, van Wijk N, Silva JP, Tremoleda JL and Michael-Titus AT (2021). A new ketogenic formulation improves functional outcome and reduces tissue loss following traumatic brain injury in adult mice. Ivyspring International Publisher Theranostics vol. 11, (1) 346-360. 2020
Tremoleda JL and Kerton A (2020). Creating space to build emotional resilience in the animal research community. Springer Nature Lab Animal vol. 49, (10) 275-277. Nandi M, Jackson SK, Macrae D, Shankar-Hari M, Tremoleda JL and Lilley E (2020). Rethinking animal models of sepsis – working towards improved clinical translation whilst integrating the 3Rs. Portland Press Clinical Science vol. 134, (13) 1715-1734. Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin MB, Vinci C, Law HL, Perretti M, Norling LV, Azevedo HS and Nissim A (2020). Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody. Frontiers Media Frontiers in Immunology vol. 11, 2019
Lopez Tremoleda J, Wall J, Naganathar V, Praditsuktavorn B, Bugg O, Mcarthur S, Thiemermann C and Brohi K (2019). Modelling cardiac dysfunction following traumatic haemorrhage injury: impact on myocardial integrity. Frontiers Media Frontiers in Immunology vol. 10, Thau-Zuchman O, Ingram R, Harvey GG, Cooke T, Palmas F, Pallier PN, Brook J, Priestley JV, Dalli J, Tremoleda JL and Michael-Titus AT (2019). A Single Injection of Docosahexaenoic Acid Induces a Pro-Resolving Lipid Mediator Profile in the Injured Tissue and a Long-Lasting Reduction in Neurological Deficit after Traumatic Brain Injury in Mice. Mary Ann Liebert Journal of Neurotrauma vol. 37, (1) 66-79. Yip PK, Chapman GE, Sillito RR, Ip THR, Akhigbe G, Becker SC, Price AW, Michael-Titus AT, Armstrong JD and Tremoleda JL (2019). Studies on long term behavioural changes in group-housed rat models of brain and spinal cord injury using an automated home cage recording system. Elsevier Journal of Neuroscience Methods vol. 321, 49-63. 2018
THAU ZUCHMAN O, Gomes RN, DYALL SC, Davies M, PRIESTLEY JV, Groenendijk M, De Wilde MC, LOPEZ TREMOLEDA J and MICHAEL-TITUS AT (2018). Brain phospholipid precursors administered post-injury reduce tissue damage and improve neurological outcome in experimental traumatic brain injury. Mary Ann Liebert Journal of Neurotrauma vol. 36, (1) 25-42. Tremoleda JL, Macholl S and Sosabowski JK (2018). Anesthesia and Monitoring of Animals During MRI Studies. Preclinical MRI Springer Nature 2017
Lopez-Tremoleda J, Alvarez K, ADEN A, DONNAN RS, MICHAEL-TITUS AT and TOMLINS PH (2017). Heart-rate sensitive optical coherence angiography for measuring vascular changes due to posttraumatic brain injury in mice. Society of Photo-optical Instrumentation Engineers Journal of Biomedical Optics vol. 22, (12) 121710-121710. Tremoleda JL, Watts SA, Reynolds PS, Thiemermann C and Brohi K (2017). Modeling Acute Traumatic Hemorrhagic Shock Injury. Wolters Kluwer Shock vol. 48, (6) 610-623. Chan JMS, Monaco C, Wylezinska-Arridge M, Tremoleda JL, Cole JE, Goddard M, Cheung MSH, Bhakoo KK and Gibbs RGJ (2017). Imaging vulnerable plaques by targeting inflammation in atherosclerosis using fluorescent-labeled dual-ligand microparticles of iron oxide and magnetic resonance imaging. Elsevier Journal of Vascular Surgery vol. 67, (5) 1571-1583.e3. Schrantee A, Tremoleda JL, Wylezinska-Arridge M, Bouet V, Hesseling P, Meerhoff GF, de Bruin KM, Koeleman J, Freret T, Boulouard M, Desfosses E, Galineau L, Gozzi A, Dauphin F, Gsell W, Booij J, Lucassen PJ and Reneman L (2017). Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate. Public Library of Science PLoS One vol. 12, (2) e0172776-e0172776. Yip PK, Carrillo-Jimenez A, King P, Vilalta A, Nomura K, Chau CC, Egerton AMS, Liu Z-H, Shetty AJ, Tremoleda JL, Davies M, Deierborg T, Priestley JV, Brown GC, Michael-Titus AT, Venero JL and Burguillos MA (2017). Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration. Nature Publishing Group Scientific Reports vol. 7, 41689-41689. 2016
Pedrigi RM, Mehta VV, Bovens SM, Mohri Z, Poulsen CB, Gsell W, Tremoleda JL, Towhidi L, de Silva R, Petretto E and Krams R (2016). Influence of shear stress magnitude and direction on atherosclerotic plaque composition. The Royal Society Royal Society Open Science vol. 3, (10) LOPEZ TREMOLEDA J (2016). In vivo PET imaging of the neuroinflammatory response
in rat spinal cord injury using the TSPO tracer [18F]GE-180
and effect of docosahexaenoic acid. Eur J Nucl Med Mol Imaging Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Vadivelu KC, Yip PK, Sosabowski J, Trigg W and Michael-Titus AT (2016). In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [18F]GE-180 and effect of docosahexaenoic acid. European Journal of Nuclear Medicine and Molecular Imaging Luong L, Duckles H, Schenkel T, Mahmoud M, Tremoleda JL, Wylezinska-Arridge M, Ali M, Bowden NP, Villa-Uriol M-C, van der Heiden K, Xing R, Gijsen FJ, Wentzel J, Lawrie A, Feng S, Arnold N, Gsell W, Lungu A, Hose R, Spencer T, Halliday I, Ridger V and Evans PC (2016). Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries. Thieme Thrombosis and Haemostasis vol. 116, (01) 181-190. Thau-Zuchman O, Pallier PN, Davies M, Groenendijk M, de Wilde MC, Tremoleda JL and Michael-Titus AT (2016). A specific multi-nutrient intervention, designed to enhance synapse formation and function, improves functional outcome following traumatic brain injury. BRAIN INJURY vol. 30, (5-6) 679-679. 2015
Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Trigg W, Sosabowski J, Mather SJ and Michael-Titus A (2015). T-14: IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION. Shock vol. 44 Suppl 2, 24-25. Tremoleda JL and Sosabowski J (2015). Imaging technologies and basic considerations for welfare of laboratory rodents. Springer Nature Lab Animal vol. 44, (3) 97-105. Tremoleda JL and Sosabowski J (2015). Imaging technologies and basic considerations for welfare of laboratory rodents. LAB ANIMAL vol. 44, (3) 101-109. 2014
Mehta VV, Pedrigi RM, Bovens SM, Tremoleda JL, Gsell W and Krams R (2014). Longitudinal predictive analysis of vulnerable plaques in a mouse model of atherosclerosis. Elsevier Atherosclerosis vol. 237, (2) Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ, Kwak BR, Bird J, Davenport AP, Clark J, Haskard D, Krams R, Jones H and Evans PC (2014). In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106. SAGE Publications Molecular Imaging vol. 13, (6) Guerreiro M, Tremoleda JL, Frith D, Thiemermann C and Brohi K (2014). Reduction of the natural Activated protein C pathway activity significantly prevents coagulopathy in a murine model of acute traumatic coagulopathy. Springer Nature Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine vol. 22, (Suppl 1) Chan JMS, Monaco C, Wylezinska-Arridge M, Tremoleda JL and Gibbs RGJ (2014). Imaging of the Vulnerable Carotid Plaque: Biological Targeting of Inflammation in Atherosclerosis Using Iron Oxide Particles and MRI. Elsevier Journal of Vascular Surgery vol. 59, (5) Chan JMS, Monaco C, Wylezinska-Arridge M, Tremoleda JL and Gibbs RGJ (2014). Imaging of the Vulnerable Carotid Plaque: Biological Targeting of Inflammation in Atherosclerosis using Iron Oxide Particles and MRI. Elsevier European Journal of Vascular and Endovascular Surgery vol. 47, (5) 462-469. 2013
Lopez-Tremoleda J and Gsell W (2013). The use of contrast agents to enhance soft-tissue imaging using micro-CT in laboratory rodents. Animal Technology and Welfare vol. 12, (1) 59-62. Cristante E, McArthur S, Mauro C, Maggioli E, Romero IA, Wylezinska-Arridge M, Couraud PO, Lopez-Tremoleda J, Christian HC, Weksler BB, Malaspina A and Solito E (2013). Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications. Proc Natl Acad Sci U S A vol. 110, (3) 832-841. Stasiuk GJ, Smith H, Wylezinska-Arridge M, Tremoleda JL, Trigg W, Luthra SK, Iveson VM, Gavins FNE and Long NJ (2013). Gd 3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation. Royal Society of Chemistry (RSC) Chemical Communications vol. 49, (6) 564-566. 2012
Tremoleda JL, Khan NS, Mann V, Racey SN, Martin AJ, Simpson AHWR and Noble BS (2012). Assessment of a preclinical model for studying the survival and engraftment of human stem cell derived osteogenic cell populations following orthotopic implantation. Journal of musculoskeletal & neuronal interactions vol. 12, (4) 241-253. Van Doormaal MA, Kazakidi A, Wylezinska M, Hunt A, Tremoleda JL, Protti A, Bohraus Y, Gsell W, Weinberg PD and Ethier CR (2012). Haemodynamics in the mouse aortic arch computed from MRI-derived velocities at the aortic root. The Royal Society Journal of The Royal Society Interface vol. 9, (76) 2834-2844. Bouet V, Klomp A, Freret T, Wylezinska-Arridge M, Lopez-Tremoleda J, Dauphin F, Boulouard M, Booij J, Gsell W and Reneman L (2012). Age-dependent effects of chronic fluoxetine treatment on the serotonergic system one week following treatment. Psychopharmacology (Berl) vol. 221, (2) 329-339. Seyfried F, Lannoo M, Gsell W, Tremoleda JL, Bueter M, Olbers T, Jurowich C, Germer C-T and le Roux CW (2012). Roux-en-Y Gastric Bypass in Mice—Surgical Technique and Characterisation. Springer Nature Obesity Surgery vol. 22, (7) 1117-1125. Tremoleda JL, Kerton A and Gsell W (2012). Anaesthesia and physiological monitoring during in vivo imaging of laboratory rodents: considerations on experimental outcomes and animal welfare. Springer Nature EJNMMI Research vol. 2, (1) 2011
Klomp A, Tremoleda JL, Wylezinska M, Nederveen AJ, Feenstra M, Gsell W and Reneman L (2011). Lasting effects of chronic fluoxetine treatment on the late developing rat brain: Age-dependent changes in the serotonergic neurotransmitter system assessed by pharmacological MRI. Elsevier NeuroImage vol. 59, (1) 218-226. Song W, Dyer E, Stuckey DJ, Copeland O, Leung M-C, Bayliss C, Messer A, Wilkinson R, Tremoleda JL, Schneider MD, Harding SE, Redwood CS, Clarke K, Nowak K, Monserrat L, Wells D and Marston SB (2011). Molecular Mechanism of the E99K Mutation in Cardiac Actin (ACTC Gene) That Causes Apical Hypertrophy in Man and Mouse*. Elsevier Journal of Biological Chemistry vol. 286, (31) 27582-27593. Cuhlmann S, Van der Heiden K, Saliba D, Tremoleda JL, Khalil M, Zakkar M, Chaudhury H, Luong LA, Mason JC, Udalova I, Gsell W, Jones H, Haskard DO, Krams R and Evans PC (2011). Disturbed Blood Flow Induces RelA Expression via c-Jun N-Terminal Kinase 1. Wolters Kluwer Circulation Research vol. 108, (8) 950-959. Tremoleda JL, Khalil M, Gompels LL, Wylezinska-Arridge M, Vincent T and Gsell W (2011). Imaging technologies for preclinical models of bone and joint disorders. Springer Nature EJNMMI Research vol. 1, (1) Tremoleda JL, Khalil M, Gsell W and Vincent T (2011). The use of micro-computed tomography to study bone changes in a preclinical model of Osteoarthritis. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING vol. 38, S418-S418. Gsell W, Cuhlmann S, Van der Heiden K, Tremoleda JL, Khalil M, Clark J, Bird J, Jones H, Krams R and Evans PC (2011). 18FEDAA is a more specific probe than 18FDG for imaging vascular inflammation. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING vol. 38, S210-S210. 2009
Khan NS, Tremoleda JL, Riahi S, Lucendo B, Pier D, Hughes O, Mann V, Dauphin DS and Noble BS (2009). 488 POTENTIAL OF HUMAN EMBRYONIC STEM CELL-DERIVED CHONDROGENIC CELLS TO REPAIR AN ARTICULAR DEFECT. Elsevier Osteoarthritis and Cartilage vol. 17,