Dr Jordi Lopez-Tremoleda
Reader in Animal Science & Welfare / Names Veterinary Surgeonn and Welfare Officer at QMUL
Blizard Institute
Queen Mary University of London
Queen Mary University of London
Research
Refinements in vivo modelling, Lab animal Care & welfare, Preclinical testing, Brain injury modelling, Preclinical Imaging, Transition towards alternatives
Interests
Academic veterinarian with vast expertise on in vivo preclinical modeling and in vivo refinements. I have a great interest to support the development of innovative alternative approaches and, particularly, support training and education of in vivo researchers and technical staff to engage with in vitro modelling and engage with the development and validation of these in vitro technologies.Publications
2024
To our esteemed colleague J-PTremoleda J, Jirkof P, Lang A and Sanchez-Morgado JM
Laboratory Animals, Sage Publications vol. 58 (6), 510-511.
01-12-2024
Our 61st Annual Meeting: An exciting programme is shaping up!Tremoleda JL
Laboratory Animals, Sage Publications vol. 58 (5), 499-499.
01-10-2024
The cellular senescence response and neuroinflammation in juvenile mice following controlled cortical impact and repetitive mild traumatic brain injuryAl-Khateeb ZF, Boumenar H, Adebimpe J, Shekerzade S, Henson SM, Tremoleda JL and Michael-Titus AT
Experimental Neurology, Elsevier vol. 374
05-02-2024
2023
Myocardial alterations following traumatic hemorrhagic injurySimpson R, Praditsuktavorn B, Wall J, Morales V, Thiemermann C, Tremoleda JL and Brohi K
Journal of Trauma and Acute Care Surgery, Wolters Kluwer vol. 95 (4), 481-489.
29-05-2023
Development and application of a novel in vivo overload model of the Achilles tendon in ratGains CC, Giannapoulos A, Zamboulis DE, Lopez-Tremoleda J and Screen HRC
Journal of Biomechanics, Elsevier vol. 151
15-03-2023
A successful return to in-person LASA Annual Conference 2022Warner A, Law B and Tremoleda JL
Laboratory Animals, Sage Publications vol. 57 (1), 87-88.
01-02-2023
Engaging on discussions about the use and the replacement of animals in research with young mindsTremoleda JL, Cederroth C and Jirkof P
Laboratory Animals, Sage Publications vol. 57 (3), 221-223.
16-01-2023
2022
Traumatic injury patterns in humans from large feline predators: A systematic review and descriptive analysisKirtland J, Tremoleda JL and Trivedy C
Trauma (London, England), Sage Publications vol. 26 (1), 28-42.
26-12-2022
Reducing the Number of Research Animals: How Imaging Technologies Can HelpTremoleda JL
Frontiers For Young Minds, Frontiers vol. 10
11-10-2022
New perspectives for teaching Culture of Care and their strengths and challengesTremoleda JL, Kerton A, Mazhary H and Greenhough B
Laboratory Animals, Sage Publications vol. 57 (2), 170-181.
06-10-2022
C-type natriuretic peptide preserves central neurological function by maintaining blood-brain barrier integrityPerez-Ternero C, Pallier PN, Tremoleda JL, Delogu A, Fernandes C, Michael-Titus AT and Hobbs AJ
Frontiers in Molecular Neuroscience, Frontiers vol. 15
04-10-2022
Is it time for a ‘Culture of Carers’?Sánchez-Morgado JM, Jirkof P, Lang A, Mocho J-P and Tremoleda JL
Laboratory Animals, Sage Publications vol. 56 (6), 498-498.
26-06-2022
How to publish a case report in Laboratory Animals?Sánchez-Morgado JM, Whitfield L, Tremoleda JL, Mocho J-P, Lang A and Jirkof P
Laboratory Animals, Sage Publications vol. 57 (1), 2-2.
26-06-2022
Deep learning for behaviour classification in a preclinical brain injury modelTeoh L, Ihalage AA, Harp S, Al-Khateeb ZF, Michael-Titus AT, Tremoleda JL and Hao Y
Plos One, Public Library of Science (Plos) vol. 17 (6)
15-06-2022
Success for our first Virtual LASA Annual ConferenceTremoleda JL and Law B
Laboratory Animals, Sage Publications vol. 56 (2), 201-203.
01-04-2022
Report from the 11th edition of the World Congress on Alternatives and Animal Use in the Life Sciences (WC11)Lang A, Jirkof P, Mocho J-P, Sanchez-Morgado J and Tremoleda JL
Laboratory Animals, Sage Publications vol. 56 (1), 101-102.
07-01-2022
2021
Parentally deprived juvenile Owl monkeys suffer from long‐term high infection rates but not from altered hair cortisol concentrations nor from stereotypic behavioursOsman M, Olkun A, Maldonado AM, Lopez‐Tremoleda J, Sanchez‐Perea N and Paredes UM
Journal of Medical Primatology, Wiley vol. 50 (6), 306-312.
07-10-2021
Do you want to join our Editorial Board?Jirkof P, Lang A, Mocho J-P, Sanchez-Morgado J and Tremoleda JL
Laboratory Animals, Sage Publications vol. 55 (3), 202-214.
28-04-2021
O1: DISCOVERING NOVEL THERAPEUTICS TO TREAT ACUTE TRAUMATIC COAGULOPATHY (ATC)Thaventhiran A, Thiemermann C, Brohi K, Tremoleda J and Davenport R
British Journal of Surgery, Oxford University Press (Oup) vol. 108 (Supplement_1)
27-04-2021
News from the EIC teamJirkof P, Sanchez-Morgado J and Tremoleda JL
Laboratory Animals, Sage Publications vol. 55 (2), 189-189.
01-04-2021
Emotional challenges in our work with laboratory animals: tools that support caring for others and yourselfKerton A and Tremoleda JL
Animal Technology and Welfare vol. 20 (1), 35-41.
01-04-2021
Guiding principles to help deliver the ethics learning outcomes of module 2 for personal licenseesJennings M, Berdoy M, Farmer AM, Hawkins P, Lilley E, Kerton A, Law B, Tremoleda JL, Stanford C, Whitfield L and Ryder K
Animal Technology and Welfare vol. 20 (1), 63-72.
01-04-2021
Teaching a culture of care: Why it mattersTremoleda JL and Kerton A
Revista De BioéTica Y Derecho, Edicions De La Universitat De Barcelona (51), 43-60.
17-02-2021
A new ketogenic formulation improves functional outcome and reduces tissue loss following traumatic brain injury in adult miceThau-Zuchman O, Svendsen L, Dyall SC, Paredes-Esquivel U, Rhodes M, Priestley JV, Feichtinger RG, Kofler B, Lotstra S, Martin Verkuyl J, Hageman RJ, Broersen LM, van Wijk N, Silva JP, Tremoleda JL and Michael-Titus AT
Theranostics, Ivyspring International Publisher vol. 11 (1), 346-360.
01-01-2021
2020
Creating space to build emotional resilience in the animal research communityTremoleda JL and Kerton A
Lab Animal, Springer Nature vol. 49 (10), 275-277.
31-08-2020
Rethinking animal models of sepsis – working towards improved clinical translation whilst integrating the 3RsNandi M, Jackson SK, Macrae D, Shankar-Hari M, Tremoleda JL and Lilley E
Clinical Science, Portland Press vol. 134 (13), 1715-1734.
10-07-2020
Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific AntibodyTopping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin MB, Vinci C, Law HL, Perretti M, Norling LV, Azevedo HS and Nissim A
Frontiers in Immunology, Frontiers Media vol. 11
14-02-2020
2019
Modelling cardiac dysfunction following traumatic haemorrhage injury: impact on myocardial integrityLopez Tremoleda J, Wall J, Naganathar V, Praditsuktavorn B, Bugg O, Mcarthur S, Thiemermann C and Brohi K
Frontiers in Immunology, Frontiers Media vol. 10
06-12-2019
A Single Injection of Docosahexaenoic Acid Induces a Pro-Resolving Lipid Mediator Profile in the Injured Tissue and a Long-Lasting Reduction in Neurological Deficit after Traumatic Brain Injury in MiceThau-Zuchman O, Ingram R, Harvey GG, Cooke T, Palmas F, Pallier PN, Brook J, Priestley JV, Dalli J, Tremoleda JL and Michael-Titus AT
Journal of Neurotrauma, Mary Ann Liebert vol. 37 (1), 66-79.
06-09-2019
Studies on long term behavioural changes in group-housed rat models of brain and spinal cord injury using an automated home cage recording systemYip PK, Chapman GE, Sillito RR, Ip THR, Akhigbe G, Becker SC, Price AW, Michael-Titus AT, Armstrong JD and Tremoleda JL
Journal of Neuroscience Methods, Elsevier vol. 321, 49-63.
13-04-2019
2018
Brain phospholipid precursors administered post-injury reduce tissue damage and improve neurological outcome in experimental traumatic brain injuryTHAU ZUCHMAN O, Gomes RN, DYALL SC, Davies M, PRIESTLEY JV, Groenendijk M, De Wilde MC, LOPEZ TREMOLEDA J and MICHAEL-TITUS AT
Journal of Neurotrauma, Mary Ann Liebert vol. 36 (1), 25-42.
14-12-2018
Anesthesia and Monitoring of Animals During MRI StudiesTremoleda JL, Macholl S and Sosabowski JK
In Preclinical Mri, Springer Nature 423-439.
01-01-2018
2017
Heart-rate sensitive optical coherence angiography for measuring vascular changes due to posttraumatic brain injury in miceLopez-Tremoleda J, Alvarez K, ADEN A, DONNAN RS, MICHAEL-TITUS AT and TOMLINS PH
Journal of Biomedical Optics, Society of Photo-Optical Instrumentation Engineers vol. 22 (12), 121710-121710.
05-12-2017
Modeling Acute Traumatic Hemorrhagic Shock InjuryTremoleda JL, Watts SA, Reynolds PS, Thiemermann C and Brohi K
Shock, Wolters Kluwer vol. 48 (6), 610-623.
01-12-2017
Imaging vulnerable plaques by targeting inflammation in atherosclerosis using fluorescent-labeled dual-ligand microparticles of iron oxide and magnetic resonance imagingChan JMS, Monaco C, Wylezinska-Arridge M, Tremoleda JL, Cole JE, Goddard M, Cheung MSH, Bhakoo KK and Gibbs RGJ
Journal of Vascular Surgery, Elsevier vol. 67 (5), 1571-1583.e3.
22-06-2017
Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate.Schrantee A, Tremoleda JL, Wylezinska-Arridge M, Bouet V, Hesseling P, Meerhoff GF, de Bruin KM, Koeleman J, Freret T, Boulouard M, Desfosses E, Galineau L, Gozzi A, Dauphin F, Gsell W, Booij J, Lucassen PJ and Reneman L
Plos One, Public Library of Science vol. 12 (2), e0172776-e0172776.
27-02-2017
Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration.Yip PK, Carrillo-Jimenez A, King P, Vilalta A, Nomura K, Chau CC, Egerton AMS, Liu Z-H, Shetty AJ, Tremoleda JL, Davies M, Deierborg T, Priestley JV, Brown GC, Michael-Titus AT, Venero JL and Burguillos MA
Scientific Reports, Nature Publishing Group vol. 7, 41689-41689.
27-01-2017
2016
Influence of shear stress magnitude and direction on atherosclerotic plaque compositionPedrigi RM, Mehta VV, Bovens SM, Mohri Z, Poulsen CB, Gsell W, Tremoleda JL, Towhidi L, de Silva R, Petretto E and Krams R
Royal Society Open Science, The Royal Society vol. 3 (10)
01-10-2016
In vivo PET imaging of the neuroinflammatory response
in rat spinal cord injury using the TSPO tracer [18F]GE-180
and effect of docosahexaenoic acidLOPEZ TREMOLEDA J
Eur J Nucl Med Mol Imaging
07-05-2016
In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [18F]GE-180 and effect of docosahexaenoic acidTremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Vadivelu KC, Yip PK, Sosabowski J, Trigg W and Michael-Titus AT
European Journal of Nuclear Medicine and Molecular Imaging
07-05-2016
Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteriesLuong L, Duckles H, Schenkel T, Mahmoud M, Tremoleda JL, Wylezinska-Arridge M, Ali M, Bowden NP, Villa-Uriol M-C, van der Heiden K, Xing R, Gijsen FJ, Wentzel J, Lawrie A, Feng S, Arnold N, Gsell W, Lungu A, Hose R, Spencer T, Halliday I, Ridger V and Evans PC
Thrombosis and Haemostasis, Thieme vol. 116 (01), 181-190.
01-01-2016
A specific multi-nutrient intervention, designed to enhance synapse formation and function, improves functional outcome following traumatic brain injuryThau-Zuchman O, Pallier PN, Davies M, Groenendijk M, de Wilde MC, Tremoleda JL and Michael-Titus AT
Brain Injury vol. 30 (5-6), 679-679.
01-01-2016
2015
T-14: IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION.Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Trigg W, Sosabowski J, Mather SJ and Michael-Titus A
Shock vol. 44 Suppl 2, 24-25.
01-10-2015
Imaging technologies and basic considerations for welfare of laboratory rodentsTremoleda JL and Sosabowski J
Lab Animal, Springer Nature vol. 44 (3), 97-105.
17-02-2015
Imaging technologies and basic considerations for welfare of laboratory rodentsTremoleda JL and Sosabowski J
Lab Animal vol. 44 (3), 101-109.
01-01-2015
2014
Longitudinal predictive analysis of vulnerable plaques in a mouse model of atherosclerosisMehta VV, Pedrigi RM, Bovens SM, Tremoleda JL, Gsell W and Krams R
Atherosclerosis, Elsevier vol. 237 (2)
01-12-2014
In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ, Kwak BR, Bird J, Davenport AP, Clark J, Haskard D, Krams R, Jones H and Evans PC
Molecular Imaging, Sage Publications vol. 13 (6)
01-08-2014
Reduction of the natural Activated protein C pathway activity significantly prevents coagulopathy in a murine model of acute traumatic coagulopathyGuerreiro M, Tremoleda JL, Frith D, Thiemermann C and Brohi K
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, Springer Nature vol. 22 (Suppl 1)
07-07-2014
Imaging of the Vulnerable Carotid Plaque: Biological Targeting of Inflammation in Atherosclerosis Using Iron Oxide Particles and MRIChan JMS, Monaco C, Wylezinska-Arridge M, Tremoleda JL and Gibbs RGJ
Journal of Vascular Surgery, Elsevier vol. 59 (5)
01-05-2014
Imaging of the Vulnerable Carotid Plaque: Biological Targeting of Inflammation in Atherosclerosis using Iron Oxide Particles and MRIChan JMS, Monaco C, Wylezinska-Arridge M, Tremoleda JL and Gibbs RGJ
European Journal of Vascular and Endovascular Surgery, Elsevier vol. 47 (5), 462-469.
01-03-2014
2013
The use of contrast agents to enhance soft-tissue imaging using micro-CT in laboratory rodentsLopez-Tremoleda J and Gsell W
Animal Technology and Welfare vol. 12 (1), 59-62.
01-04-2013
Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications.Cristante E, McArthur S, Mauro C, Maggioli E, Romero IA, Wylezinska-Arridge M, Couraud PO, Lopez-Tremoleda J, Christian HC, Weksler BB, Malaspina A and Solito E
Proc Natl Acad Sci U S A vol. 110 (3), 832-841.
15-01-2013
Gd 3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammationStasiuk GJ, Smith H, Wylezinska-Arridge M, Tremoleda JL, Trigg W, Luthra SK, Iveson VM, Gavins FNE and Long NJ
Chemical Communications, Royal Society of Chemistry (Rsc) vol. 49 (6), 564-566.
01-01-2013
2012
Assessment of a preclinical model for studying the survival and engraftment of human stem cell derived osteogenic cell populations following orthotopic implantation.Tremoleda JL, Khan NS, Mann V, Racey SN, Martin AJ, Simpson AHWR and Noble BS
Journal of Musculoskeletal & Neuronal Interactions vol. 12 (4), 241-253.
01-12-2012
Haemodynamics in the mouse aortic arch computed from MRI-derived velocities at the aortic rootVan Doormaal MA, Kazakidi A, Wylezinska M, Hunt A, Tremoleda JL, Protti A, Bohraus Y, Gsell W, Weinberg PD and Ethier CR
Journal of The Royal Society Interface, The Royal Society vol. 9 (76), 2834-2844.
04-07-2012
Age-dependent effects of chronic fluoxetine treatment on the serotonergic system one week following treatment.Bouet V, Klomp A, Freret T, Wylezinska-Arridge M, Lopez-Tremoleda J, Dauphin F, Boulouard M, Booij J, Gsell W and Reneman L
Psychopharmacology (Berl) vol. 221 (2), 329-339.
01-05-2012
Roux-en-Y Gastric Bypass in Mice—Surgical Technique and CharacterisationSeyfried F, Lannoo M, Gsell W, Tremoleda JL, Bueter M, Olbers T, Jurowich C, Germer C-T and le Roux CW
Obesity Surgery, Springer Nature vol. 22 (7), 1117-1125.
24-04-2012
Anaesthesia and physiological monitoring during in vivo imaging of laboratory rodents: considerations on experimental outcomes and animal welfareTremoleda JL, Kerton A and Gsell W
Ejnmmi Research, Springer Nature vol. 2 (1)
01-01-2012
2011
Lasting effects of chronic fluoxetine treatment on the late developing rat brain: Age-dependent changes in the serotonergic neurotransmitter system assessed by pharmacological MRIKlomp A, Tremoleda JL, Wylezinska M, Nederveen AJ, Feenstra M, Gsell W and Reneman L
Neuroimage, Elsevier vol. 59 (1), 218-226.
04-08-2011
Molecular Mechanism of the E99K Mutation in Cardiac Actin (ACTC Gene) That Causes Apical Hypertrophy in Man and Mouse*Song W, Dyer E, Stuckey DJ, Copeland O, Leung M-C, Bayliss C, Messer A, Wilkinson R, Tremoleda JL, Schneider MD, Harding SE, Redwood CS, Clarke K, Nowak K, Monserrat L, Wells D and Marston SB
Journal of Biological Chemistry, Elsevier vol. 286 (31), 27582-27593.
26-05-2011
Disturbed Blood Flow Induces RelA Expression via c-Jun N-Terminal Kinase 1Cuhlmann S, Van der Heiden K, Saliba D, Tremoleda JL, Khalil M, Zakkar M, Chaudhury H, Luong LA, Mason JC, Udalova I, Gsell W, Jones H, Haskard DO, Krams R and Evans PC
Circulation Research, Wolters Kluwer vol. 108 (8), 950-959.
24-02-2011
Imaging technologies for preclinical models of bone and joint disordersTremoleda JL, Khalil M, Gompels LL, Wylezinska-Arridge M, Vincent T and Gsell W
Ejnmmi Research, Springer Nature vol. 1 (1)
01-01-2011
The use of micro-computed tomography to study bone changes in a preclinical model of OsteoarthritisTremoleda JL, Khalil M, Gsell W and Vincent T
European Journal of Nuclear Medicine and Molecular Imaging vol. 38, S418-S418.
01-01-2011
18FEDAA is a more specific probe than 18FDG for imaging vascular inflammationGsell W, Cuhlmann S, Van der Heiden K, Tremoleda JL, Khalil M, Clark J, Bird J, Jones H, Krams R and Evans PC
European Journal of Nuclear Medicine and Molecular Imaging vol. 38, S210-S210.
01-01-2011
2009
488 POTENTIAL OF HUMAN EMBRYONIC STEM CELL-DERIVED CHONDROGENIC CELLS TO REPAIR AN ARTICULAR DEFECTKhan NS, Tremoleda JL, Riahi S, Lucendo B, Pier D, Hughes O, Mann V, Dauphin DS and Noble BS
Osteoarthritis and Cartilage, Elsevier vol. 17
01-09-2009
Grants
The role of the TREM-1 pathway in major traumaKarim Brohi and Jordi Lopez-Tremoleda
£50,805 Inotrem SA
01-11-2020 - 30-04-2021