Prof Julia Shelton
Professor of Biomechanical Engineering
Director of Operations for Centre for Doctoral Training in next generation organ-on-a-chip technology (CoACT)
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
in vitro models of bone, multiscale modelling, total hip replacements, implant coatings, biomechanics, implant wear
Interests
I am interested in the response of the body to implants during physiological use, and how to improve outcomes. This includes the development and testing of innovative coatings for Total Hip Replacements to reduce metal ion release and for these to be antibacterial. In addition we are developing an improved understanding of taper connections in modular implants through multiscale modelling to simulate the interaction of taper surfaces. This links to research using in vitro models and organ-chip technology to study bone remodelling.Publications
Publications of specific relevance to Predictive in vitro Models2023
Diaz-Lopez RA, Wen PH and Shelton JC (2023). Influence of Taper surface topographies on contact deformation and stresses. Elsevier Journal of the Mechanical Behavior of Biomedical Materials vol. 148, 2022
Diaz-Lopez RA, Wen PH and Shelton JC (2022). Influence of taper design and loading on taper micromotion. Elsevier Journal of the Mechanical Behavior of Biomedical Materials vol. 128, 2021
Wu H, Wang Z, Liu S, Meng H, Shelton JC, Thompson CL, Fu S and Knight MM (2021). Sub-toxic levels of cobalt ions impair mechanostranduction via HDAC6-depedent primary cilia shortening. Biochem Biophys Res Commun 2020
Xu J, Yang J, Chen J, Zhang X, Wu Y, Hart A, Nyga A and Shelton JC (2020). Activation of synovial fibroblasts from patients at revision of their metal-on-metal total hip arthroplasty. BioMed Central Particle and Fibre Toxicology vol. 17, (1) 42-42. Di Federico E, Bader DL and Shelton JC (2020). 3D models of chondrocytes within biomimetic scaffolds: Effects of cell deformation from loading regimens. Elsevier BV Clinical Biomechanics 2019
Fu S, Meng H, Freer F, Kwon J, Shelton JC and Knight MM (2019). Sub-toxic levels of Co2+ are anti-inflammatory and protect cartilage from degradation caused by IL-1β. Elsevier Clinical Biomechanics vol. 79, VADGAMA PM (2019). An electrochemical study of acrylate bone adhesive permeability and selectivity change during in vitro ageing: a model approach to the study of biomaterials and membrane barriers. Elsevier Masson Analytica Chimica Acta 2018
Rowson DT, Shelton JC, Screen HRC and Knight MM (2018). Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6. Springer Nature Scientific Reports vol. 8, (1) Xu J, Nyga A, Li W, Zhang X, Gavara N, Knight MM and Shelton JC (2018). Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages. European Cells and Materials vol. 36, 142-155. SHELTON JC (2018). Prediction of taper performance using quasi static FE models: The influence of loading and taper clearance and trunnion length. Journal of Biomedical Materials Research: Part B - Applied Biomaterials SHELTON JC (2018). Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated downregulation of RhoA expression. Elsevier Acta Biomaterialia vol. 72, 434-446. Xu J, Yang J, Nyga A, Ehteramyan M, Moraga A, Wu Y, Zeng L, Knight MM and Shelton JC (2018). Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression. Acta Biomater vol. 72, 434-446. 2017
Clarke I, Shelton J, Bowsher J, Savisaar C and Donaldson T (2017). Simulator Study of MOM using Steep-cup Flexion - A Clinically Relevant Incorporation of Intermittent Edge-loading. Joint Implant Surgery and Research Foundation Reconstructive Review vol. 7, (3) Di Federico E, SHELTON JC and Bader DL (2017). Complex mechanical conditioning of cell-seeded agarose constructs can influence chondrocyte biosynthetic activity. Wiley Biotechnology and Bioengineering 2016
de Villiers D and Shelton JC (2016). Measurement outcomes from hip simulators. SAGE Publications Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine vol. 230, (5) 398-405. 2015
de Villiers D, Traynor A, Collins SN and Shelton JC (2015). The increase in cobalt release in metal-on-polyethylene hip bearings in tests with third body abrasives. SAGE Publications Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine vol. 229, (9) 611-618. de Villiers D, Traynor A, Collins SN, Banfield S, Housden J and Shelton JC (2015). Chromium nitride coating for large diameter metal-on-polyethylene hip bearings under extreme adverse hip simulator conditions. Elsevier Wear vol. 328, 363-368. 2014
Di Federico E, Bader DL and Shelton JC (2014). Design and validation of an in vitro loading system for the combined application of cyclic compression and shear to 3D chondrocytes-seeded agarose constructs. Med Eng Phys vol. 36, (4) 534-540. Hothi HS, Busfield JJC and Shelton JC (2014). Deformation of uncemented metal acetabular cups following impaction: Experimental and finite element study. Computer Methods in Biomechanics and Biomedical Engineering vol. 17, (11) 1261-1274. 2013
Screen HRC, Toorani S and Shelton JC (2013). Microstructural stress relaxation mechanics in functionally different tendons. Med Eng Phys vol. 35, (1) 96-102. Screen HRC, Toorani S and Shelton JC (2013). Microstructural stress relaxation mechanics in functionally different tendons. Medical Engineering and Physics vol. 35, (1) 96-102. 2012
Lu F, Royle M, Lali FV, Hart AJ, Collins S, Housden J and Shelton JC (2012). Simple isolation method for the bulk isolation of wear particles from metal on metal bearing surfaces generated in a hip simulator test. Journal of Materials Science: Materials in Medicine vol. 23, (4) 891-901. Lu F, Royle M, Lali FV, Hart AJ, Collins S, Housden J and Shelton JC (2012). Simple isolation method for the bulk isolation of wear particles from metal on metal bearing surfaces generated in a hip simulator test. Journal of Materials Science: Materials in Medicine 1-11. 2011
Morris B, Zou L, Royle M, Simpson D and Shelton JC (2011). Quantifying the wear of acetabular cups using coordinate metrology. Wear vol. 271, (7-8) 1086-1092. Hothi HS, Busfield JJC and Shelton JC (2011). Explicit finite element modelling of the impaction of metal press-fit acetabular components. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine vol. 225, (3) 303-314. 2010
McConlogue T, Mueller J and Shelton J (2010). Challenges of developing engineering students' writing through peer assessment. Engineering Education 2010: Inspiring the Next Generation of Engineers, EE 2010 Maeda E, Fleischmann C, Mein CA, Shelton JC, Bader DL and Lee DA (2010). Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strain. Connective Tissue Research vol. 51, (6) 434-444. 2009
Maeda E, Shelton JC, Bader DL and Lee DA (2009). Effect of intermittent cyclic tensile strain on collagen synthesis by tenocytes in isolated fascicles. Journal of Biomechanical Science and Engineering vol. 4, (4) 510-517. Angadji A, Royle M, Collins SN and Shelton JC (2009). Influence of cup orientation on the wear performance of metal-on-metal hip replacements. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine vol. 223, (4) 449-457. Maeda E, Shelton JC, Bader DL and Lee DA (2009). Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitro. Journal of Applied Physiology vol. 106, (2) 506-512. Berry CC, Shelton JC and Lee DA (2009). Cell-generated forces influence the viability, metabolism and mechanical properties of fibroblast-seeded collagen gel constructs. J Tissue Eng Regen Med vol. 3, (1) 43-53. 2008
Toorani S, Shelton JC and Screen HRC (2008). Characterizing structure-function relationships in tendon. 8th World Biomaterials Congress 2008 vol. 2, Angadji A, Grossmann H, Royle M, Collins SN and Shelton JC (2008). Affect of cup positioning on the wear performance and wear particles from metal-on-metal hip replacements. 8th World Biomaterials Congress 2008 vol. 2, Maeda E, Shelton JC, Bader DL and Lee DA (2008). Collagen synthesis by tenocytes in fascicles subjected to intermittent cyclic strain. European Cells and Materials vol. 16, (SUPPL. 3) Schulz RM, Wüstneck N, Van Donkelaar CC, Shelton JC and Bader A (2008). Development and validation of a novel bioreactor system for load- and perfusion-controlled tissue engineering of chondrocyte-constructs. Biotechnology and Bioengineering vol. 101, (4) 714-728. Mootanah R, Jarrett P, Ingle P, Cheah K, Dowell JK and Shelton JC (2008). Configuration of anchorage holes affects cemented fixation of the acetabular component in total hip replacement: an in vitro study. Technol Health Care vol. 16, (1) 19-30. 2007
Mootanah R, Dowell JK, Cheah K, Ingle P and Shelton JC (2007). Configuration of anchorage holes affects fixation of the acetabular component in cemented total hip replacement--a finite element study. Comput Methods Biomech Biomed Engin vol. 10, (6) 439-445. Maeda E, Shelton JC, Bader DL and Lee DA (2007). Time dependence of cyclic tensile strain on collagen production in tendon fascicles. Biochem Biophys Res Commun vol. 362, (2) 399-404. 2006
Screen HRC, Chhaya VH, Greenwald SE, Bader DL, Lee DA and Shelton JC (2006). The influence of swelling and matrix degradation on the microstructural integrity of tendon. Acta Biomater vol. 2, (5) 505-513. Bowsher JG, Nevelos J, Williams PA and Shelton JC (2006). 'Severe' wear challenge to 'as-cast' and 'double heat-treated' large-diameter metal-on-metal hip bearings. P I MECH ENG H vol. 220, (H2) 135-143. Bowsher JG, Hussain A, Williams PA and Shelton JC (2006). Metal-on-metal hip simulator study of increased wear particle surface area due to 'severe' patient activity. Proc Inst Mech Eng H vol. 220, (2) 279-287. 2005
Screen HRC, Bader DL, Shelton JC and Lee DA (2005). Cyclic mechanical conditioning of isolated tendon fascicles results in an upregulation of collagen production. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 193-194. Screen HRC, Shelton JC, Bader DL and Lee DA (2005). Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles. Biochem Biophys Res Commun vol. 336, (2) 424-429. Screen HRC, Shelton JC, Chhaya VH, Kayser MV, Bader DL and Lee DA (2005). The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles. Ann Biomed Eng vol. 33, (8) 1090-1099. Mulholland JW, Shelton JC and Luo XY (2005). Blood flow and damage by the roller pumps during cardiopulmonary bypass. J FLUID STRUCT vol. 20, (1) 129-140. 2004
Bowsher JG, Hussain A, Williams P, Nevelos J and Shelton JC (2004). Effect of ion implantation on the tribology of metal-on-metal hip prostheses. J Arthroplasty vol. 19, (8 Suppl 3) 107-111. Bader DL, Shelton JC, Lee DA and SCREEN HRC (2004). Local Strain Measurement within Tendon. Strain vol. 40, (4) 157-163. Sawae Y, Shelton JC, Bader DL and Knight MM (2004). Confocal analysis of local and cellular strains in chondrocyte-agarose constructs subjected to mechanical shear. Ann Biomed Eng vol. 32, (6) 860-870. Silwood CJL, Chikanza IC, Tanner KE, Shelton JC, Bowsher JG and Grootveld M (2004). Investigation of the molecular nature of low-molecular-mass cobalt(II) ions in isolated osteoarthritic knee-joint synovial fluid. FREE RADICAL RES vol. 38, (6) 561-571. Mootanah R, Ingle P, Cheah K, Dowell JK and Shelton JC (2004). Total hip replacement: Results of a postal survey of current practice on the cement fixation of the acetubular cup in the UK. HIP International vol. 14, (3) 155-162. Screen HRC, Lee DA, Bader DL and Shelton JC (2004). An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties. Proc Inst Mech Eng H vol. 218, (2) 109-119. Fisher J, SHELTON JC and Nevelos J (2004). Metallurgical Considerations in the Wear of Metal-Metal Hip Bearings. Hip International vol. 14, 1-10. 2003
Chowdhury TT, Bader DL, Shelton JC and Lee DA (2003). Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression. Arch Biochem Biophys vol. 417, (1) 105-111. Berry CC, Shelton JC, Bader DL and Lee DA (2003). Influence of external uniaxial cyclic strain on oriented fibroblast-seeded collagen gels. Tissue Eng vol. 9, (4) 613-624. Bader DL, SHELTON JC, Knight MM and Sawae Y (2003). Confocal Analysis of Local and Cellular Strains in Chondrocyte - Agarose Constructs Subjected to Shear. J Biochemical Engineering ASME Shelton JC, Bader DL and Lee DA (2003). Mechanical conditioning influences the metabolic response of cell-seeded constructs. Cells Tissues Organs vol. 175, (3) 140-150. Berry CC, Cacou C, Lee DA, Bader DL and Shelton JC (2003). Dermal fibroblasts respond to mechanical conditioning in a strain profile dependent manner. Biorheology vol. 40, (1-3) 337-345. Screen HRC, Lee DA, Bader DL and Shelton JC (2003). Development of a technique to determine strains in tendons using the cell nuclei. Biorheology vol. 40, (1-3) 361-368. Chowdhury TT, LEE DA, Salter DM, Shelton JC and Bader DL (2003). alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta-stimulated human chondrocyte / agarose constructs and subjected to dynamic compression. Osteoarthritis Cartilage vol. 11, (Suppl 1) S2-S3. Chowdhury TT, Shelton JC, Bader DL and LEE DA (2003). Control of mechanotrasduction processes in dynamically stimulated human and bovine chondrocytes cultured in agarose constructs. Internat. J. Artificial Organs vol. 26, (9) 858-858. 2002
Berry CC, Shelton JC, Bader DL and Lee DA (2002). The influence of uniaxial cyclic strain on orientated fibroblast seeded collagen gels. Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products Kakunai S, Sakamoto T, Sakurai D, Aota Y and Shelton J (2002). Profile measurement of worn acetabular cup by holographic contouring. JSME INT J C-MECH SY vol. 45, (4) 1028-1032. SHELTON JC, Revell PA and Mushipe MT (2002). Enhancement of cancellous bone repair using particulates. Biomaterials vol. 23, 365-370. BADER DL, Shelton JC, Lee DA and Screen HRC (2002). Development of a technique to determine strains in tendons using the cell nuclei. Biorheology vol. 40, 361-368. SHELTON JC, Revell PA and Mushipe MT (2002). Comparison of influence of cortical bone repair using autologous and Endobon particulates. J Mats Sci: Materials in Medicine vol. 13, 99-105. Saadalla ME, Ahad N, Gibson IR and Shelton JC (2002). Comparison between commercial calcium phosphate bone cements., Editors: Brown S, Clarke I and Williams P. BIOCERAMICS 14 vol. 218-2, 331-334. Mushipe MT, Revell PA and Shelton JC (2002). The effects of bovine trabecular bone matrix particulates on cortical bone repair. J Mater Sci Mater Med vol. 13, (1) 99-105. Bader DL, Shelton JC, Lee DA and SCREEN HRC (2002). Non-collagenous matrix components influence the micromechanical environment of tenocytes within tendon fascicles subjected to tensile strain. Eur. Cells Mat. vol. 4:S1, 41-42. Mushipe MT, Revell PA and Shelton JC (2002). Cancellous bone repair using bovine trabecular bone matrix particulates. Biomaterials vol. 23, (2) 365-370. 2001
Zou L, Samarawickrama DYD, Jovanovski V and Shelton JC (2001). Measurements of sequential impressions of acetabula cups from a total hip joint replacement using a non-contact measurement system. INTERNATIONAL JOURNAL OF MACHINE TOOLS & MANUFACTURE vol. 41, (13-14) 2023-2030. SHELTON JC and Bowsher JG (2001). A hip simulator study of the influence of patient activity level on the wear of crosslinked polyethylene under smooth and roughened femoral conditions. Wear vol. 250, (1-2) 167-179. Ind TEJ, Shelton JC and Shepherd JH (2001). Influence of training on reliability of surgical knots. BRIT J OBSTET GYNAEC vol. 108, (10) 1013-1016. 2000
Berry CC, Cacou C, Shelton JC, Bader DL and Lee DA (2000). Biological response of cyclic strain on developed cell seeded collagen gel model. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Mulholland JW, Massey W and Shelton JC (2000). Investigation and quantification of the blood trauma caused by the combined dynamic forces experienced during cardiopulmonary bypass. Perfusion vol. 15, (6) 485-494. Cacou C, Palmer D, Lee DA, Bader DL and Shelton JC (2000). A system for monitoring the response of uniaxial strain on cell seeded collagen gels. MED ENG PHYS vol. 22, (5) 327-333. Mootanah R, Ingle P, Dowell J, Cheah K and Shelton JC (2000). Fixation of the acetabular cup in cemented total hip replacement: improving the anchorage hole profile using finite element method. Technol Health Care vol. 8, (6) 343-355. 1998
Kobayashi E, Doi H, Yoneyama T, Hamanaka H, Gibson IR, Best SM, Shelton JC and Bonfield W (1998). Influence of aging heat treatment on mechanical properties of biomedical Ti-Zr based ternary alloys containing niobium. J Mater Sci Mater Med vol. 9, (11) 625-630. Mo N and Shelton JC (1998). Laser speckle photography to measure surface displacements on cortical bone--verification of an automated analysis system. Med Eng Phys vol. 20, (8) 594-601. Katz DM, Blatcher S and Shelton JC (1998). Quantification of holographic fringe data: comparison of intact and implanted femurs. Med Eng Phys vol. 20, (2) 114-123. 1996
Forrest DJ, Shelton JC and Gregson PJ (1996). Fatigue failure in a plasma sprayed hydroxyapatite coated titanium alloy. Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium vol. 1, McDougall I, Gregson PJ and Shelton JC (1996). Multiaxial fatigue testing of medical grade titanium alloy. Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium vol. 1, Kobayashi E, Doi H, Yoneyama T, Hamanaka H, Best SM, Shelton JC and Bonfield W (1996). Alloy-design of titanium-zirconium based alloys containing niobium as biomedical materials. Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium vol. 2, Gong F, Swain P, Kadirkamanathan S, Hepworth C, Laufer J, Shelton J and Mills T (1996). Cutting thread at flexible endoscopy. Gastrointest Endosc vol. 44, (6) 667-674. Horgan LF, Shelton JC, O'Riordan DC, Moore DP, Winslet MC and Davidson BR (1996). Strengths and weaknesses of laparoscopic and open mesh inguinal hernia repair: a randomized controlled experimental study. Br J Surg vol. 83, (10) 1463-1467. Shelton JC and Loukota RA (1996). Pull-out strength of screws from cortical bone in the maxillo-facial region. J MATER SCI-MATER M vol. 7, (4) 231-235. Kadirkamanathan SS, Shelton JC, Hepworth CC, Laufer JG and Swain CP (1996). A comparison of the strength of knots tied by hand and at laparoscopy. J Am Coll Surg vol. 182, (1) 46-54. 1995
Loukota RA and Shelton JC (1995). Mechanical analysis of maxillofacial miniplates. Br J Oral Maxillofac Surg vol. 33, (3) 174-179. KADIRKAMANATHAN SS, LAUFER JG, HEPWORTH CC, SHELTON JC and SWAIN CP (1995). ARE KNOTS TIED AT LAPAROSCOPY AS SECURE AS HAND TIED KNOTS. GASTROINTEST ENDOSC vol. 41, (4) 432-432. 1993
Netti PA, Shelton JC, Revell PA, Pirie C, Smith S, Ambrosio L, Nicolais L and Bonfield W (1993). Hydrogels as an interface between bone and an implant. Biomaterials vol. 14, (14) 1098-1104. 1991
Shelton JC and Katz DM (1991). Laser interferometric techniques in orthopaedics. J Med Eng Technol vol. 15, (6) 209-221. 1990
SHELTON JC, GORMAN D and BONFIELD W (1990). THE APPLICATION OF HOLOGRAPHY TO EXAMINE PLATED FRACTURE FIXATION SYSTEMS. J MATER SCI-MATER M vol. 1, (3) 146-153. 1989
Shelton JC, Gorman D and Bonfield W (1989). Double exposure holographic interferometric evaluation of plated fracture systems. Journal of Biomechanics vol. 22, (10) Grants
Grants of specific relevance to Predictive in vitro ModelsOrgan-chip Facility: A world-class in vitro models facility for the UK community, reducing the barriers to adoption to drive animal replacementHazel Screen, Stefaan Verbruggen, Martin Knight, Julia Shelton, Timothy Hopkins and John Connelly
£573,537 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research (07-10-2024 - 14-03-2025)
(EPSRC CDT 2023) Next Generation Organ-on-a-Chip TechnologiesHazel Screen, Martin Knight, Thomas Iskratsch, Caroline Roney, Yi Sui, David Lee, Julia Shelton, Tsz Ho Tse, John Connelly, Adrian Biddle and Lucy Norling
£7,066,811 EPSRC Engineering and Physical Sciences Research Council (01-07-2024 - 30-09-2032)