Prof Jane Sosabowski

Jane Sosabowski

Professor of Radionuclide Imaging and Therapy

Centre for Cancer Biomarkers and Biotherapeutics, Barts Cancer Institute
Queen Mary University of London

Research

in vivo imaging, radiochemistry, radionuclide therapy, in vivo biodistribution

Interests

Interest in off-target toxicity excretory organs (e.g. kidney) of radiopharmaceutical therapies. Approach by NPL interested in radiobiology models

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2024

Receptor-Targeted Peptide Conjugates Based on Diphosphines Enable Preparation of 99mTc and 188Re Theranostic Agents for Prostate Cancer
Pham TT, Hungnes IN, Rivas C, Cleaver J, Firth G, Blower PJ, Sosabowski J, Cook GJR, Livieratos L, Young JD, Pringle PG and T. M
Journal of Nuclear Medicine, Society of Nuclear Medicine vol. 65 (7) 
06-06-2024
Selection of radionuclide(s) for targeted alpha therapy based on their nuclear decay properties
Ree SM, Greenwood H, Young JD, Roberts R, Livens FR, Heath SL and Sosabowski JK
Nuclear Medicine Communications, Wolters Kluwer vol. 45 (6), 465-473.  
11-03-2024

2023

Spatiotemporal tracking of gold nanorods after intranasal administration for brain targeting
Han S, Wang JT-W, Yavuz E, Zam A, Rouatbi N, Utami RN, Liam-Or R, Griffiths A, Dickson W, Sosabowski J and Al-Jamal KT
Journal of Controlled Release, Elsevier vol. 357, 606-619.  
23-04-2023

2022

MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis
Pistorius K, Ly L, Souza PR, Gomez EA, Koenis DS, Rodriguez AR, Foster J, Sosabowski J, Hopkinson M, Rajeeve V, Spur BW, Pitsillides A, Pitzalis C and Dalli J
Ebiomedicine, Elsevier vol. 79 
14-04-2022
Preclinical PET and SPECT Instrumentation
Dexter K, Foster J, Sosabowski J and Petrik M
In Nuclear Medicine and Molecular Imaging, Elsevier 473-484.  
01-01-2022
Preclinical PET and SPECT imaging
Dexter K, Foster J, Petrik M and Sosabowski J
In Nuclear Medicine and Molecular Imaging, Elsevier 662-670.  
01-01-2022

2021

New Bioconjugated Technetium and Rhenium Folates Synthesized by Transmetallation Reaction with Zinc Derivatives
Borràs J, Foster J, Kashani R, Meléndez-Alafort L, Sosabowski J, Suades J and Barnadas-Rodríguez R
Molecules, Mdpi vol. 26 (8) 
19-04-2021
Bioconjugated technetium carbonyls by transmetalation reaction with zinc derivatives
Borràs J, Lecina J, Foster J, Kashani R, Melendez-Alafort L, Sosabowski J and Suades J
Bioorganic & Medicinal Chemistry Letters, Elsevier vol. 37 
05-02-2021

2020

Simultaneous dual isotope PET-SPECT/CT imaging of pancreatic cancer
Dexter K, BROWN N, Foster J, Kashani R, CHUPIN J, Cleaver J, Cutmore L, Marshall J and Sosabowski J
 
26-08-2020
Cancer associated fibroblast FAK regulates malignant cell metabolism.
Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J, Newport E, Rajeeve V, Baker A-M, Roy-Luzarraga M, Graham TA, Foster J, Wang Y, Campbell JJ, Singh R, Zhang P, Schall TJ, Balkwill FR, Sosabowski J, Cutillas PR, Frezza C, Sancho P and Hodivala-Dilke K
Nature Communications, Nature Research (Part of Springer Nature) vol. 11 (1), 1290-1290.  
10-03-2020
Organ Biodistribution of Radiolabelled δγ T Cells Following Liposomal Alendronate Administration in Different Mice Tumour Models
Wang JT-W, Hodgins NO, Al-Jamal WT, Maher J, Sosabowski JK and Al-Jamal KT
Nanotheranostics, Ivyspring International Publisher vol. 4 (2), 71-82.  
06-02-2020
18F-Trifluoromethanesulfinate Enables Direct C–H 18F-Trifluoromethylation of Native Aromatic Residues in Peptides
Kee CW, Tack O, Guibbal F, Wilson TC, Isenegger PG, Imiołek M, Verhoog S, Tilby M, Boscutti G, Ashworth S, Chupin J, Kashani R, Poh AWJ, Sosabowski JK, Macholl S, Plisson C, Cornelissen B, Willis MC, Passchier J, Davis BG and Gouverneur V
Journal of The American Chemical Society, American Chemical Society vol. 142 (3), 1180-1185.  
22-01-2020

2019

Neutron Activated 153Sm Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy
Wang JT-W, Klippstein R, Martincic M, Pach E, Feldman R, Šefl M, Michel Y, Asker D, Sosabowski JK, Kalbac M, Da Ros T, Ménard-Moyon C, Bianco A, Kyriakou I, Emfietzoglou D, Saccavini J-C, Ballesteros B, Al-Jamal KT and Tobias G
Acs Nano, American Chemical Society (Acs) vol. 14 (1), 129-141.  
19-11-2019
Systemic delivery and SPECT/CT in vivo imaging of 125I-labelled oncolytic adenoviral mutants in models of pancreatic cancer
Stella Man YK, Foster J, Carapuça E, Davies JA, Parker AL, Sosabowski J and Halldén G
Scientific Reports, Springer Nature vol. 9 (1) 
06-09-2019
AGR2, a unique tumor-associated antigen, is a promising candidate for antibody targeting
Crnogorac-Jurcevic T, Radon T, Shah S, Weeks M, Foster J, Sosabowski J and Dumartin L
Oncotarget, Impact Journals 
02-07-2019
Site-specific stabilization of minigastrin analogs against enzymatic degradation for enhanced cholecystokinin-2 receptor targeting: Erratum
Klingler M, Decristoforo C, Rangger C, Summer D, Foster J, Sosabowski JK and von Guggenberg E
Theranostics, Ivyspring International Publisher vol. 9 (16), 4595-4596.  
19-06-2019
New Developments in Imaging Cell-Based Therapy
Martinez O, Sosabowski J, Maher J and Papa S
Journal of Nuclear Medicine, Society of Nuclear Medicine vol. 60 (6), 730-735.  
12-04-2019
Rational Design, Synthesis and Preliminary Evaluation of Novel Fusarinine C-Based Chelators for Radiolabeling with Zirconium-89
Zhai C, He S, Ye Y, Rangger C, Kaeopookum P, Summer D, Haas H, Kremser L, Lindner H, Foster J, Sosabowski J and Decristoforo C
Biomolecules, Mdpi vol. 9 (3) 
06-03-2019
Membrane Radiolabelling of Exosomes for Comparative Biodistribution Analysis in Immunocompetent and Immunodeficient Mice - A Novel and Universal Approach
Faruqu FN, Wang JT-W, Xu L, McNickle L, Chong EM-Y, Walters A, Gurney M, Clayton A, Smyth LA, Hider R, Sosabowski J and Al-Jamal KT
Theranostics, Ivyspring International Publisher vol. 9 (6), 1666-1682.  
28-02-2019

2018

DOTA-MGS5, a New Cholecystokinin-2 Receptor-Targeting Peptide Analog with an Optimized Targeting Profile for Theranostic Use
Klingler M, Summer D, Rangger C, Haubner R, Foster J, Sosabowski J, Decristoforo C, Virgolini I and von Guggenberg E
Journal of Nuclear Medicine, Society of Nuclear Medicine vol. 60 (7), 1010-1016.  
07-12-2018
Radiolabeled Antibodies Against Müllerian-Inhibiting Substance Receptor, Type II: New Tools for a Theranostic Approach in Ovarian Cancer
Deshayes E, Ladjohounlou R, Le Fur P, Pichard A, Lozza C, Boudousq V, Sevestre S, Jarlier M, Kashani R, Koch J, Sosabowski J, Foster J, Chouin N, Bruchertseifer F, Morgenstern A, Kotzki P-O, Navarro-Teulon I and Pouget J-P
Journal of Nuclear Medicine, Society of Nuclear Medicine vol. 59 (8), 1234-1242.  
19-04-2018
Site-specific stabilization of minigastrin analogs against enzymatic degradation for enhanced cholecystokinin-2 receptor targeting.
Klingler M, Decristoforo C, Rangger C, Summer D, Foster J, Sosabowski JK and von Guggenberg E
Theranostics vol. 8 (11), 2896-2908.  
16-04-2018
Clinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells.
Emami-Shahri N, Foster J, Kashani R, Gazinska P, Cook C, Sosabowski J, Maher J and Papa S
Nature Communications, Nature Publishing Group vol. 9 (1), 1081-1081.  
14-03-2018
Functionalised Carbon Nanotubes Enhance Brain Delivery of Amyloid-Targeting Pittsburgh Compound B (PiB)-Derived Ligands
Costa PM, Wang JT-W, Morfin J-F, Khanum T, To W, Sosabowski J, Tóth E and Al-Jamal KT
Nanotheranostics, Ivyspring International Publisher vol. 2 (2), 168-183.  
15-02-2018
Anesthesia and Monitoring of Animals During MRI Studies
Tremoleda JL, Macholl S and Sosabowski JK
In Preclinical Mri, Springer Nature 423-439.  
01-01-2018
12 Blockade of integrin alpha-v-beta-6 (αvβ6) reduces the invasive potential of NSCLC
Rudran B, Reader C, Foster J, Hodivala-Dilke K, Sosabowski J and Marshall J
Lung Cancer, Elsevier vol. 115, s5-s6.  
01-01-2018

2017

Investigating in vitro and in vivo αvβ6 integrin receptor-targeting liposomal alendronate for combinatory γδ T cell immunotherapy
Hodgins NO, Al-Jamal WT, Wang JT-W, Klippstein R, Costa PM, Sosabowski JK, Marshall JF, Maher J and Al-Jamal KT
Journal of Controlled Release, Elsevier vol. 256, 141-152.  
18-04-2017
High-throughput high-volume nuclear imaging for preclinical in vivo compound screening§.
Macholl S, Finucane CM, Hesterman J, Mather SJ, Pauplis R, Scully D, Sosabowski JK and Jouannot E
Ejnmmi Res, Springer Open vol. 7 (1), 33-33.  
07-04-2017
Novel Hyaluronic Acid Conjugates for Dual Nuclear Imaging and Therapy in CD44-Expressing Tumors in Mice In Vivo
Dubey RD, Klippstein R, Wang JT-W, Hodgins N, Mei K-C, Sosabowski J, Hider RC, Abbate V, Gupta PN and Al-Jamal KT
Nanotheranostics, Ivyspring International Publisher vol. 1 (1), 59-79.  
01-01-2017
6: Development of non-invasive imaging of integrin alpha-v-beta-6 (αvβ6)-positive lung cancers in advance of testing αvβ6-targeted therapies
Rudran B, Desai A, Luzarraga M, Hodivala-Dilke K, Foster J, Sosabowski J and Marshall J
Lung Cancer, Elsevier vol. 103 
01-01-2017

2016

Engineering hepatitis B virus core particles for targeting HER2 receptors in vitro and in vivo.
Mohamed Suffian IFB, Wang JT-W, Hodgins NO, Klippstein R, Garcia-Maya M, Brown P, Nishimura Y, Heidari H, Bals S, Sosabowski JK, Ogino C, Kondo A and Al-Jamal KT
Biomaterials, Elsevier vol. 120, 126-138.  
14-12-2016
Pre-clinical quantitative imaging and mouse-specific dosimetry for 111In-labelled radiotracers
Denis-Bacelar AM, Cronin SE, Da Pieve C, Paul RL, Eccles SA, Spinks TJ, Box C, Hall A, Sosabowski JK, Kramer-Marek G and Flux GD
Ejnmmi Research, Springer Nature vol. 6 (1) 
25-11-2016
Magnetic Drug Targeting: Preclinical in Vivo Studies, Mathematical Modeling, and Extrapolation to Humans
Al-Jamal KT, Bai J, Wang JT-W, Protti A, Southern P, Bogart L, Heidari H, Li X, Cakebread A, Asker D, Al-Jamal WT, Shah A, Bals S, Sosabowski J and Pankhurst QA
Nano Letters: a Journal Dedicated to Nanoscience and Nanotechnology, American Chemical Society 
19-08-2016
Localized Irradiation of Cell Membrane by Auger Electrons Is Cytotoxic Through Oxidative Stress-Mediated Nontargeted Effects
Paillas S, Ladjohounlou R, Lozza C, Pichard A, Boudousq V, Jarlier M, Sevestre S, Le Blay M, Deshayes E, Sosabowski J, Chardès T, Navarro-Teulon I, Mairs RJ and Pouget J-P
Antioxidants and Redox Signaling, Mary Ann Liebert vol. 25 (8) 
05-07-2016
In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [18F]GE-180 and effect of docosahexaenoic acid
Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Vadivelu KC, Yip PK, Sosabowski J, Trigg W and Michael-Titus AT
European Journal of Nuclear Medicine and Molecular Imaging 
07-05-2016
The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties In Vitro and In Vivo
Cabana L, Bourgognon M, Wang JT-W, Protti A, Klippstein R, de Rosales RTM, Shah AM, Fontcuberta J, Tobías-Rossell E, Sosabowski JK, Al-Jamal KT and Tobias G
Small, Wiley: 12 Months vol. 12 (21), 2893-2905.  
15-04-2016
Translocation of LRP1 targeted carbon nanotubes of different diameters across the blood–brain barrier in vitro and in vivo
Kafa H, Wang JT-W, Rubio N, Klippstein R, Costa PM, Hassan HAFM, Sosabowski JK, Bansal SS, Preston JE, Abbott NJ and Al-Jamal KT
Journal of Controlled Release, Elsevier vol. 225, 217-229.  
23-01-2016
Triple-Modal Imaging of Magnetically-Targeted Nanocapsules in Solid TumoursIn Vivo
Bai J, Wang JT-W, Rubio N, Protti A, Heidari H, Elgogary R, Southern P, Al-Jamal WT, Sosabowski J, Shah AM, Bals S, Pankhurst QA and Al-Jamal KT
Theranostics, Ivyspring International Publisher vol. 6 (3), 342-356.  
01-01-2016

2015

Kinetics of functionalised carbon nanotube distribution in mouse brain after systemic injection: Spatial to ultra-structural analyses
Wang JT-W, Rubio N, Kafa H, Venturelli E, Fabbro C, Ménard-Moyon C, Da Ros T, Sosabowski JK, Lawson AD, Robinson MK, Prato M, Bianco A, Festy F, Preston JE, Kostarelos K and Al-Jamal KT
Journal of Controlled Release, Elsevier vol. 224, 22-32.  
30-12-2015
T-14: IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION.
Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Trigg W, Sosabowski J, Mather SJ and Michael-Titus A
Shock vol. 44 Suppl 2, 24-25.  
01-10-2015
Correction: Pharmacokinetic Characteristics, Pharmacodynamic Effect and In Vivo Antiviral Efficacy of Liver-Targeted Interferon Alpha
Staff TPO
Plos One, Public Library of Science (Plos) vol. 10 (4) 
10-04-2015
Imaging technologies and basic considerations for welfare of laboratory rodents
Tremoleda JL and Sosabowski J
Lab Animal, Springer Nature vol. 44 (3), 97-105.  
17-02-2015
Pharmacokinetic Characteristics, Pharmacodynamic Effect and In Vivo Antiviral Efficacy of Liver-Targeted Interferon Alpha
Rycroft D, Sosabowski J, Coulstock E, Davies M, Morrey J, Friel S, Kelly F, Hamatake R, Ovečka M, Prince R, Goodall L, Sepp A and Walker A
Plos One, Public Library of Science (Plos) vol. 10 (2) 
17-02-2015
Development of the designed ankyrin repeat protein (DARPin) G3 for HER2 molecular imaging.
Goldstein R, Sosabowski J, Livanos M, Leyton J, Vigor K, Bhavsar G, Nagy-Davidescu G, Rashid M, Miranda E, Yeung J, Tolner B, Plückthun A, Mather S, Meyer T and Chester K
Eur J Nucl Med Mol Imaging vol. 42 (2), 288-301.  
01-02-2015
Imaging technologies and basic considerations for welfare of laboratory rodents
Tremoleda JL and Sosabowski J
Lab Animal vol. 44 (3), 101-109.  
01-01-2015

2014

Adoptive immunotherapy of epithelial ovarian cancer with Vγ9Vδ2 T cells, potentiated by liposomal alendronic acid.
Parente-Pereira AC, Shmeeda H, Whilding LM, Zambirinis CP, Foster J, van der Stegen SJC, Beatson R, Zabinski T, Brewig N, Sosabowski JK, Mather S, Ghaem-Maghami S, Gabizon A and Maher J
J Immunol vol. 193 (11), 5557-5566.  
01-12-2014
Evaluation and comparison of a new DOTA and DTPA-bombesin agonist in vitro and in vivo in low and high GRPR expressing prostate and breast tumor models
Pujatti PB, Foster JM, Finucane C, Hudson CD, Burnet JC, Pasqualoto KFM, Mengatti J, Mather SJ, de Araújo EB and Sosabowski JK
Applied Radiation and Isotopes, Elsevier vol. 96, 91-101.  
11-11-2014
PET and SPECT imaging of a radiolabeled minigastrin analogue conjugated with DOTA, NOTA, and NODAGA and labeled with (64)Cu, (68)Ga, and (111)In.
Roosenburg S, Laverman P, Joosten L, Cooper MS, Kolenc-Peitl PK, Foster JM, Hudson C, Leyton J, Burnet J, Oyen WJG, Blower PJ, Mather SJ, Boerman OC and Sosabowski JK
Mol Pharm vol. 11 (11), 3930-3937.  
03-11-2014
The relationship between the diameter of chemically-functionalized multi-walled carbon nanotubes and their organ biodistribution profiles in vivo.
Wang JT-W, Fabbro C, Venturelli E, Ménard-Moyon C, Chaloin O, Da Ros T, Methven L, Nunes A, Sosabowski JK, Mather SJ, Robinson MK, Amadou J, Prato M, Bianco A, Kostarelos K and Al-Jamal KT
Biomaterials vol. 35 (35), 9517-9528.  
01-11-2014
Magnetically decorated multiwalled carbon nanotubes as dual mri and spect contrast agents
Wang JTW, Cabana L, Bourgognon M, Kafa H, Protti A, Venner K, Shah AM, Sosabowski JK, Mather SJ, Roig A, Ke X, Van Tendeloo G, De Rosales RTM, Tobias G and Al-Jamal KT
Advanced Functional Materials vol. 24 (13), 1880-1894.  
02-04-2014
Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging.
Allen MD, Luong P, Hudson C, Leyton J, Delage B, Ghazaly E, Cutts R, Yuan M, Syed N, Lo Nigro C, Lattanzio L, Chmielewska-Kassassir M, Tomlinson I, Roylance R, Whitaker HC, Warren AY, Neal D, Frezza C, Beltran L, Jones LJ, Chelala C, Wu B-W, Bomalaski JS, Jackson RC, Lu Y-J, Crook T, Lemoine NR, Mather S, Foster J and Sosabowski J
Cancer Res vol. 74 (3), 896-907.  
01-02-2014

2013

Preclinical in vivo modeling of cytokine release syndrome induced by ErbB-retargeted human T cells: identifying a window of therapeutic opportunity?
van der Stegen SJC, Davies DM, Wilkie S, Foster J, Sosabowski JK, Burnet J, Whilding LM, Petrovic RM, Ghaem-Maghami S, Mather S, Jeannon J-P, Parente-Pereira AC and Maher J
J Immunol vol. 191 (9), 4589-4598.  
01-11-2013
Developments in single photon emission computed tomography and PET-based HER2 molecular imaging for breast cancer.
Goldstein R, Sosabowski J, Vigor K, Chester K and Meyer T
Expert Rev Anticancer Ther vol. 13 (3), 359-373.  
01-03-2013
Liver-targeting of interferon-alpha with tissue-specific domain antibodies.
Coulstock E, Sosabowski J, Ovečka M, Prince R, Goodall L, Mudd C, Sepp A, Davies M, Foster J, Burnet J, Dunlevy G and Walker A
Plos One vol. 8 (2) 
01-01-2013
Magnetically Decorated Multiwalled Carbon Nanotubes as Dual MRI and SPECT Contrast Agents
Wang JT-W, Cabana L, Bourgognon M, Kafa H, Protti A, Venner K, Shah AM, Sosabowski JK, Mather SJ, Roig A, Ke X, Van Tendeloo G, de Rosales RTM, Tobias G and Al-Jamal KT
Advanced Functional Materials 
01-01-2013
Tumor targeting and imaging with dual-peptide conjugated multifunctional liposomal nanoparticles.
Rangger C, Helbok A, Sosabowski J, Kremser C, Koehler G, Prassl R, Andreae F, Virgolini IJ, von Guggenberg E and Decristoforo C
Int J Nanomedicine vol. 8, 4659-4671.  
01-01-2013

2012

Preclinical evaluation of radiolabeled DOTA-derivatized cyclic minigastrin analogs for targeting cholecystokinin receptor expressing malignancies.
von Guggenberg E, Rangger C, Sosabowski J, Laverman P, Reubi J-C, Virgolini IJ and Decristoforo C
Mol Imaging Biol vol. 14 (3), 366-375.  
01-06-2012
Radiolabelled peptides for oncological diagnosis.
Laverman P, Sosabowski JK, Boerman OC and Oyen WJG
Eur J Nucl Med Mol Imaging vol. 39 Suppl 1 (Suppl 1), S78-S92.  
01-02-2012
Influence of PEGylation and RGD loading on the targeting properties of radiolabeled liposomal nanoparticles.
Rangger C, Helbok A, von Guggenberg E, Sosabowski J, Radolf T, Prassl R, Andreae F, Thurner GC, Haubner R and Decristoforo C
Int J Nanomedicine vol. 7, 5889-5900.  
01-01-2012

2011

Comparative biodistribution of 12 ¹¹¹In-labelled gastrin/CCK2 receptor-targeting peptides.
Laverman P, Joosten L, Eek A, Roosenburg S, Peitl PK, Maina T, Mäcke H, Aloj L, von Guggenberg E, Sosabowski JK, de Jong M, Reubi J-C, Oyen WJG and Boerman OC
Eur J Nucl Med Mol Imaging vol. 38 (8), 1410-1416.  
01-08-2011
Comparison of the binding and internalization properties of 12 DOTA-coupled and ¹¹¹In-labelled CCK2/gastrin receptor binding peptides: a collaborative project under COST Action BM0607.
Aloj L, Aurilio M, Rinaldi V, D'ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, von Guggenberg E, Joosten L, Sosabowski JK, Breeman WAP, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC and de Jong M
Eur J Nucl Med Mol Imaging vol. 38 (8), 1417-1425.  
01-08-2011
Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607.
Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowski JK, Breeman WAP, Reubi JC and Decristoforo C
Eur J Nucl Med Mol Imaging vol. 38 (8), 1426-1435.  
01-08-2011
Quantitative Accuracy of Low-Count SPECT Imaging in Phantom and In Vivo Mouse Studies.
Finucane CM, Murray I, Sosabowski JK, Foster JM and Mather SJ
Int J Mol Imaging vol. 2011 
01-01-2011
Radiopeptide internalisation and externalization assays: cell viability and radioligand integrity.
Naqvi SAR, Sosabowski JK, Nagra SA, Ishfaq MM, Mather SJ and Matzow T
Appl Radiat Isot vol. 69 (1), 68-74.  
01-01-2011

2010

Insertion of a lysosomal enzyme cleavage site into the sequence of a radiolabeled neuropeptide influences cell trafficking in vitro and in vivo.
Naqvi SAR, Matzow T, Finucane C, Nagra SA, Ishfaq MM, Mather SJ and Sosabowski J
Cancer Biother Radiopharm vol. 25 (1), 89-95.  
01-02-2010

2009

Targeting of CCK-2 receptor-expressing tumors using a radiolabeled divalent gastrin peptide.
Sosabowski JK, Matzow T, Foster JM, Finucane C, Ellison D, Watson SA and Mather SJ
J Nucl Med vol. 50 (12), 2082-2089.  
01-12-2009
TARGETING OF CCK2 RECEPTOR EXPRESSING TUMOURS USING AN 111IN-LABELLED MINIGASTRIN DIMER
Sosabowski J, Matzow T, Foster J and Mather S
J Labelled Compd Rad vol. 52, S327-S327.  
01-01-2009

2007

Formulation development and manufacturing of a gastrin/CCK-2 receptor targeting peptide as an intermediate drug product for a clinical imaging study.
Sosabowski JK, Lee M, Dekker BA, Simmons BP, Singh S, Beresford H, Hagan SA, McKenzie AJ, Mather SJ and Watson SA
Eur J Pharm Sci vol. 31 (2), 102-111.  
01-06-2007
Selection of radiolabeled gastrin analogs for peptide receptor-targeted radionuclide therapy.
Mather SJ, McKenzie AJ, Sosabowski JK, Morris TM, Ellison D and Watson SA
J Nucl Med vol. 48 (4), 615-622.  
01-04-2007

2006

Conjugation of DOTA-like chelating agents to peptides and radiolabeling with trivalent metallic isotopes.
Sosabowski JK and Mather SJ
Nat Protoc vol. 1 (2), 972-976.  
01-01-2006

2005

Radiopharmacy - Overcoming the training barriers
Sosabowski J and Mather SJ
Hospital Pharmacist vol. 12 (8), 311-313.  
01-09-2005
SYNTHESIS OF DICARBA ANALOGUES OF OCTREOTIDE USING TANDEM HOMOGENEOUS CATALYSIS
Whelan AN, Elaridi J, Smith SV, Mulder RJ, Robinson AJ and Sosabowski J
J Labelled Compd Rad vol. 48, S238-S238.  
01-06-2005

2003

Radiolabelling of peptides for diagnosis and therapy of non-oncological diseases
Sosabowski J, Melendez-Alafort L and Mather S
Q J Nucl Med vol. 47 (4), 223-237.  
01-12-2003
Absence of pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein alpha-subunit gene in LbetaT2 gonadotrophs reveals disrupted cAMP-mediated gene transcription.
Fowkes RC, Sidhu KK, Sosabowski JK, King P and Burrin JM
J Mol Endocrinol vol. 31 (2), 263-278.  
01-10-2003

2000

99mTc-HYNIC-[Tyr3]-octreotide for imaging somatostatin-receptor-positive tumors: preclinical evaluation and comparison with 111In-octreotide.
Decristoforo C, Melendez-Alafort L, Sosabowski JK and Mather SJ
Journal of Nuclear Medicine vol. 41 (6), 1114-1119.  
01-06-2000
Copper bis(diphosphine) complexes: radiopharmaceuticals for the detection of multi-drug resistance in tumours by PET
Lewis JS, Dearling JLJ, Sosabowski JK, Zweit J, Carnochan P, Kelland LR, Coley HM and Blower PJ
European Journal of Nuclear Medicine and Molecular Imaging, Springer Nature vol. 27 (6), 638-646.  
01-05-2000

1999

Metal complexes of bleomycin: evaluation of [Rh-105]-bleomycin for use in targeted radiotherapy
Brooks RC, Carnochan P, Vollano JF, Powell NA, Zweit J, Sosabowski JK, Martellucci S, Darkes MC, Fricker SP and Murrer BA
Nuclear Medicine and Biology, Elsevier vol. 26 (4), 421-430.  
01-05-1999

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconWhole genome CRISPR screens to map genetic determinants of radionuclide therapy of cancer
Jane Sosabowski
£40,000 ARTBIO LIMITED
01-09-2024 - 31-08-2028
bullet iconMRIP Programme Cyclife Aquila Lead-212 hot cell
Jane Sosabowski
£49,979 CAN Cyclife Aquila Nuclear
30-11-2023 - 31-03-2025
bullet iconMedical Radionuclide Innovation Programme - MRIP To Establish the First UK Production of the Alpha-Particle Emitting Radionuclide at Queen Mary University of London for the Development of UK Astatine-211 Production
Jane Sosabowski
£268,399 Department for Energy Security & Net Zero
13-11-2023 - 31-03-2025
bullet iconDevelopment of a Gallium-68 PET Clinical Imaging Service
Jane Sosabowski
£549,991 Barts and the London Charity
01-04-2022 - 12-01-2026
bullet iconDinutuximab Beta for molecular imaging and radiotherapy of high-risk neuroblastoma
Jane Sosabowski
£30,000 Neuroblastoma UK
01-04-2022 - 31-03-2025


bullet iconMulti-user micro PET/CT equipment for biomedical research
Jane Sosabowski, Julie Foster and John Marshall
£475,110 MRC Medical Research Council
01-07-2023 - 29-02-2024
bullet iconGamma delta T-cell immunotherapy in osteosarcoma II
Jane Sosabowski
£28,467 Little Princess Trust
01-09-2022 - 31-10-2024
bullet iconTargeted molecular radiotherapy of αvβ6 expressing head and neck cancer
Jane Sosabowski
£25,000 CR-UK Cancer Research UK
01-06-2022 - 31-12-2023
bullet iconGuided gamma-deltas for osteosarcoma immunotherapy
Jane Sosabowski
£9,170 CR-UK Cancer Research UK
01-04-2022 - 31-03-2023
bullet iconSupporting homing and longevity of gamma delta T-cells for cancer immunotherapy
Jane Sosabowski
£17,727 AMS Academy of Medical Sciences
01-04-2022 - 31-03-2024
bullet iconUK supply of radionuclides for molecular radiotherapy
Jane Sosabowski
£3,600 CR-UK Cancer Research UK
01-11-2021 - 31-10-2022
bullet iconTheragnostic radiopharmaceuticals for the imaging and treatment of childhood neuroblastoma
Jane Sosabowski
£12,500 CR-UK Cancer Research UK
01-05-2021 - 30-04-2022
bullet iconPANORAMA Study
Prabhakar Rajan and Jane Sosabowski
Barts and the London Charity
01-01-2020 - 31-12-2020
bullet iconImplementation of a 3D Computational Mouse Atlas for Detection of Pancreatic Tumours in Transgenic Mice
Jane Sosabowski
£98,713 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research
01-10-2019 - 31-03-2021
bullet iconCiCinAT: PET tracking of cell therapies
Jane Sosabowski
£13,063 King's College London (KCL)
01-07-2019 - 13-10-2021
bullet iconOptimizing CAR T efficacy through the WNK1 pathway
Jane Sosabowski
£10,577 King's College London (KCL)
01-06-2019 - 31-08-2020
bullet iconImproved characterisation of disease models for validation of quantative PET and SPECT in vivo imaging
Jane Sosabowski
£331,952 INVICRO LLC
01-04-2018 - 16-09-2022
bullet iconRadiolabelling and in vitro evaluation of biotherapeutics
Jane Sosabowski
£24,480 INVICRO LLC
15-01-2018 - 14-01-2019
bullet iconDevelopment of a 3D mouse atlas tool for improved non-invasive imaging of orthoptopic mouse models of pancreatic cancer
Jane Sosabowski
£90,000 MRC Medical Research Council
05-10-2015 - 30-09-2018
bullet iconDevelopment of nuclear and optical imaging techniques to characterise the distribution kinetics of therapeutic macromoleuler in disease
Jane Sosabowski
£31,998 GSK GlaxoSmithKline UK Ltd
01-10-2014 - 30-09-2018