Dr Livia Carvalho

Livia Carvalho

Senior Lecturer in Neuropsychopharmacology

Department of Clinical Pharmacology and Precision Medicine
QMUL

Research

immunology, receptor function, mental health, psychotropic drugs, biomarker development, drug effect prediction

Interests

I have over ten. years experience in culturing human blood cells and investigating receptor function with implication for mental illness and treatment. Would be interested in developing a model for immune system interaction and or blood brain barrier

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2024

Souza-Teodoro LH, Davies NM, Warren HR, Andrade LHSG and Carvalho LA (2024). DHEA and response to antidepressant treatment: A Mendelian Randomization analysis. Elsevier  Journal of Psychiatric Research  vol. 173, 151-156.  
Weston G, Zilanawala A, Webb E, Carvalho L and McMunn A (2024). Work hours, weekend working, nonstandard work schedules and sleep quantity and quality: findings from the UK household longitudinal study. Springer Nature  BMC Public Health  vol. 24, (1)  

2022

Jayakumar S, Jennings S, Halvorsrud K, Clesse C, Yaqoob MM, Carvalho LA and Bhui K (2022). A systematic review and meta-analysis of the evidence on inflammation in depressive illness and symptoms in chronic and end-stage kidney disease. Cambridge University Press (CUP)  Psychological Medicine  vol. 53, (12) 5839-5851.  
Clesse C, Yaqoob MM, Jayakumar S, Bhui K and Carvalho LA (2022). Investigating inflammation in depression in the chronically ill: Theoretical model and perspectives. SAGE Publications  The Journal of the Royal College of Physicians of Edinburgh  vol. 52, (3) 247-252.  
Souza-Teodoro LH, Andrade LHSG and Carvalho LA (2022). Could dehydroepiandrosterone (DHEA) be a novel target for depression? Elsevier  Journal of Affective Disorders Reports  vol. 8,  

2020

Khandaker GM, Zuber V, Rees JMB, Carvalho L, Mason AM, Foley CN, Gkatzionis A, Jones PB and Burgess S (2020). Correction: Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort. Springer Nature  Molecular Psychiatry  vol. 26, (7) 3659-3661.  
Hanns L, Radziszewska A, Suffield L, Josephs F, Chaplin H, Peckham H, Sen D, Christie D, Carvalho LA and Ioannou Y (2020). Association of Anxiety With Pain and Disability but Not With Increased Measures of Inflammation in Adolescent Patients With Juvenile Idiopathic Arthritis. Wiley  Arthritis Care & Research  vol. 72, (9) 1266-1274.  

2019

Wittenberg GM, Stylianou A, Zhang Y, Sun Y, Gupta A, Jagannatha PS, Wang D, Hsu B, Curran ME, Khan S, Chen G, Bullmore ET and Drevets WC (2019). Effects of immunomodulatory drugs on depressive symptoms: A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders. Springer Nature  Molecular Psychiatry  vol. 25, (6) 1275-1285.  
Sforzini L, Pariante CM, Palacios JE, Tylee A, Carvalho LA, Viganò CA and Nikkheslat N (2019). Inflammation associated with coronary heart disease predicts onset of depression in a three-year prospective follow-up: A preliminary study. Elsevier  Brain Behavior and Immunity  vol. 81, 659-664.  
Khandaker GM, Zuber V, Rees JMB, Carvalho L, Mason AM, Foley CN, Gkatzionis A, Jones PB and Burgess S (2019). Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort. Springer Nature  Molecular Psychiatry  vol. 25, (7) 1477-1486.  
Weston G, Zilanawala A, Webb E, Carvalho LA and McMunn A (2019). Long work hours, weekend working and depressive symptoms in men and women: findings from a UK population-based study. BMJ  Journal of Epidemiology & Community Health  vol. 73, (5)  

2018

Liljas AEM, Walters K, de Oliveira C, Wannamethee SG, Ramsay SE and Carvalho LA (2018). Self-Reported Sensory Impairments and Changes in Cognitive Performance: A Longitudinal 6-Year Follow-Up Study of English Community-Dwelling Adults Aged ⩾50 Years. SAGE Publications  Journal of Aging and Health  vol. 32, (5-6) 243-251.  
Carvalho KMB, Ronca DB, Michels N, Huybrechts I, Cuenca-Garcia M, Marcos A, Molnár D, Dallongeville J, Manios Y, Schaan BD, Moreno L, de Henauw S and Carvalho LA (2018). Does the Mediterranean Diet Protect against Stress-Induced Inflammatory Activation in European Adolescents? The HELENA Study. MDPI  Nutrients  vol. 10, (11)  
RONALDSON AL, Carvalho LA, Kostich K, Lazzarino AI and Steptoe A (2018). The effects of six-day SSRI administration on diurnal cortisol secretion in healthy volunteers. Springer Verlag  Psychopharmacology  vol. 235, (12) 3415-3422.  
Lawes S, Demakakos P, Steptoe A, Lewis G and Carvalho LA (2018). Combined influence of depressive symptoms and systemic inflammation on all-cause and cardiovascular mortality: evidence for differential effects by gender in the English Longitudinal Study of Ageing. Cambridge University Press (CUP)  Psychological Medicine  vol. 49, (9) 1521-1531.  
Michels N, Clarke G, Olavarria-Ramirez L, Gómez-Martínez S, Díaz LE, Marcos A, Widhalm K and Carvalho LA (2018). Psychosocial stress and inflammation driving tryptophan breakdown in children and adolescents: A cross-sectional analysis of two cohorts. Elsevier  Psychoneuroendocrinology  vol. 94, 104-111.  
Steptoe A, Ronaldson A, Kostich K, Lazzarino AI, Urbanova L and Carvalho LA (2018). The effect of beta-adrenergic blockade on inflammatory and cardiovascular responses to acute mental stress. Elsevier BV  Brain, Behavior, and Immunity  vol. 70, 369-375.  
Hanns L, Cordingley L, Galloway J, Norton S, Carvalho LA, Christie D, Sen D, Carrasco R, Rashid A, Foster H, Baildam E, Chieng A, Davidson J, Wedderburn LR, Hyrich K, Thomson W and Ioannou Y (2018). Depressive symptoms, pain and disability for adolescent patients with juvenile idiopathic arthritis: results from the Childhood Arthritis Prospective Study. Oxford University Press (OUP)  Rheumatology  vol. 57, (8) 1381-1389.  

2017

Liljas AEM, Carvalho LA, Papachristou E, De Oliveira C, Wannamethee SG, Ramsay SE and Walters KR (2017). Self-reported vision impairment and incident prefrailty and frailty in English community-dwelling older adults: findings from a 4-year follow-up study. BMJ  Journal of Epidemiology & Community Health  vol. 71, (11)  
Bell JA, Kivimäki M, Bullmore ET, Steptoe A and Carvalho LA (2017). Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults. Springer Nature  Translational Psychiatry  vol. 7, (8) e1208-e1208.  
Leday GGR, Vértes PE, Richardson S, Greene JR, Regan T, Khan S, Henderson R, Freeman TC, Pariante CM, Harrison NA, Perry H, Drevets W, Wittenberg G, Bullmore E, Bullmore ET, Vertes P, Cardinal R, Leday G, Freeman T, Hume D, Wu Z, Pariante C, Cattaneo A, Zunszain P, Borsini A, Stewart R, Chandran D and Carvalho L (2017). Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder. Elsevier  Biological Psychiatry  vol. 83, (1) 70-80.  
Nikkheslat N, Zunszain PA, Carvalho LA, Anacker C and Pariante CM (2017). Antidepressant Actions on Glucocorticoid Receptors. Stress: Neuroendocrinology and Neurobiology  

2016

Liljas AEM, Carvalho LA, Papachristou E, De Oliveira C, Wannamethee SG, Ramsay SE and Walters K (2016). Self‐Reported Hearing Impairment and Incident Frailty in English Community‐Dwelling Older Adults: A 4‐Year Follow‐Up Study. Wiley  Journal of the American Geriatrics Society  vol. 65, (5) 958-965.  
Liljas AEM, Wannamethee SG, Whincup PH, Papacosta O, Walters K, Iliffe S, Lennon LT, Carvalho LA and Ramsay SE (2016). Hearing impairment and incident disability and all-cause mortality in older British community-dwelling men. Oxford University Press (OUP)  Age and Ageing  vol. 45, (5) 662-667.  
Fancourt D, Williamon A, Carvalho LA, Steptoe A, Dow R and Lewis I (2016). Singing modulates mood, stress, cortisol, cytokine and neuropeptide activity in cancer patients and carers. Ecancer Global Foundation  Ecancermedicalscience  vol. 10,  
Fancourt D, Perkins R, Ascenso S, Carvalho LA, Steptoe A and Williamon A (2016). Effects of Group Drumming Interventions on Anxiety, Depression, Social Resilience and Inflammatory Immune Response among Mental Health Service Users. Public Library of Science (PLoS)  PLOS ONE  vol. 11, (3)  
Liljas AEM, Wannamethee SG, Whincup PH, Papacosta O, Walters K, Iliffe S, Lennon LT, Carvalho LA and Ramsay SE (2016). Sensory Impairments and Cardiovascular Disease Incidence and Mortality in Older British Community‐Dwelling Men: A 10‐Year Follow‐Up Study. Wiley  Journal of the American Geriatrics Society  vol. 64, (2) 442-444.  

2015

Fancourt D, Perkins R, Ascenso S, Atkins L, Kilfeather S, Carvalho L, Steptoe A and Williamon A (2015). Group Drumming Modulates Cytokine Response in Mental Health Services Users: A Preliminary Study. Karger Publishers  Psychotherapy and Psychosomatics  vol. 85, (1) 53-55.  
Souza-Teodoro LH, de Oliveira C, Walters K and Carvalho LA (2015). Higher serum dehydroepiandrosterone sulfate protects against the onset of depression in the elderly: Findings from the English Longitudinal Study of Aging (ELSA). Elsevier  Psychoneuroendocrinology  vol. 64, 40-46.  
Endrighi R, Hamer M, Hackett RA, Carvalho LA, Jackson SE, Wardle J and Steptoe A (2015). Effect of short-term weight loss on mental stress-induced cardiovascular and pro-inflammatory responses in women. Taylor & Francis  Stress  vol. 18, (5) 602-606.  
Liljas AEM, Wannamethee SG, Whincup PH, Papacosta O, Walters K, Iliffe S, Lennon LT, Carvalho LA and Ramsay SE (2015). Socio-demographic characteristics, lifestyle factors and burden of morbidity associated with self-reported hearing and vision impairments in older British community-dwelling men: a cross-sectional study. Oxford University Press (OUP)  Journal of Public Health  vol. 38, (2) e21-e28.  
Lazzarino AI, Hamer M, Carvalho L, Gaze D, Collinson P and Steptoe A (2015). The mediation of coronary calcification in the association between risk scores and cardiac troponin T elevation in healthy adults: Is atherosclerosis a good prognostic precursor of coronary disease? Elsevier  Preventive Medicine  vol. 77, 150-154.  
Grosse L, Carvalho LA, Birkenhager TK, Hoogendijk WJ, Kushner SA, Drexhage HA and Bergink V (2015). Circulating cytotoxic T cells and natural killer cells as potential predictors for antidepressant response in melancholic depression. Restoration of T regulatory cell populations after antidepressant therapy. Springer Nature  Psychopharmacology  vol. 233, (9) 1679-1688.  
Hackett RA, Lazzarino AI, Carvalho LA, Hamer M and Steptoe A (2015). Hostility and Physiological Responses to Acute Stress in People With Type 2 Diabetes. Wolters Kluwer  Psychosomatic Medicine  vol. 77, (4) 458-466.  
Zalli A, Jovanova O, Hoogendijk WJG, Tiemeier H and Carvalho LA (2015). Low-grade inflammation predicts persistence of depressive symptoms. Springer Nature  Psychopharmacology  vol. 233, (9) 1669-1678.  
Ronaldson A, Gazali AM, Zalli A, Kaiser F, Thompson SJ, Henderson B, Steptoe A and Carvalho L (2015). Increased percentages of regulatory T cells are associated with inflammatory and neuroendocrine responses to acute psychological stress and poorer health status in older men and women. Springer Nature  Psychopharmacology  vol. 233, (9) 1661-1668.  
Nikkheslat N, Zunszain PA, Horowitz MA, Barbosa IG, Parker JA, Myint A-M, Schwarz MJ, Tylee AT, Carvalho LA and Pariante CM (2015). Insufficient glucocorticoid signaling and elevated inflammation in coronary heart disease patients with comorbid depression. Elsevier  Brain Behavior and Immunity  vol. 48, 8-18.  
Carvalho LA, Gerdes JM, Strell C, Wallace GR and Martins JO (2015). Interplay between the Endocrine System and Immune Cells. Hindawi  BioMed Research International  vol. 2015, (1)  

2014

Steptoe A, Hackett RA, Lazzarino AI, Bostock S, La Marca R, Carvalho LA and Hamer M (2014). Disruption of multisystem responses to stress in type 2 diabetes: Investigating the dynamics of allostatic load. Proceedings of the National Academy of Sciences  Proceedings of the National Academy of Sciences of the United States of America  vol. 111, (44) 15693-15698.  
Carvalho LA, Urbanova L, Hamer M, Hackett RA, Lazzarino AI and Steptoe A (2014). Blunted glucocorticoid and mineralocorticoid sensitivity to stress in people with diabetes. Elsevier  Psychoneuroendocrinology  vol. 51, 209-218.  
Grosse L, Carvalho LA, Wijkhuijs AJM, Bellingrath S, Ruland T, Ambrée O, Alferink J, Ehring T, Drexhage HA and Arolt V (2014). Clinical characteristics of inflammation-associated depression: Monocyte gene expression is age-related in major depressive disorder. Elsevier  Brain Behavior and Immunity  vol. 44, 48-56.  
Rybka J, Kędziora-Kornatowska K, Banaś-Leżańska P, Majsterek I, Carvalho LA, Cattaneo A, Anacker C and Kędziora J (2014). Corrigendum to “Interplay between the pro-oxidant and antioxidant system, and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression” [Free Rad. Bio. Med. 63C (2013) 187–194]. Elsevier  Free Radical Biology and Medicine  vol. 69,  
Zalli A, Carvalho LA, Lin J, Hamer M, Erusalimsky JD, Blackburn EH and Steptoe A (2014). Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources. Proceedings of the National Academy of Sciences  Proceedings of the National Academy of Sciences of the United States of America  vol. 111, (12) 4519-4524.  
Kidd T, Carvalho LA and Steptoe A (2014). The relationship between cortisol responses to laboratory stress and cortisol profiles in daily life. Elsevier  Biological Psychology  vol. 99, (100) 34-40.  
Petros N and Carvalho LA (2014). The role of mineralocorticoid receptors in major depressive disorder. Horizons in Neuroscience Research  
Carvalho LA, Bergink V, Sumaski L, Wijkhuijs J, Hoogendijk WJ, Birkenhager TK and Drexhage HA (2014). Inflammatory activation is associated with a reduced glucocorticoid receptor alpha/beta expression ratio in monocytes of inpatients with melancholic major depressive disorder. Springer Nature  Translational Psychiatry  vol. 4, (1) e344-e344.  

2013

Rybka J, Kędziora-Kornatowska K, Banaś-Leżańska P, Majsterek I, Carvalho LA, Cattaneo A, Anacker C and Kędziora J (2013). Interplay between the pro-oxidant and antioxidant systems and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression. Elsevier  Free Radical Biology and Medicine  vol. 63, 187-194.  

2012

Carvalho LA, Torre JP, Papadopoulos AS, Poon L, Juruena MF, Markopoulou K, Cleare AJ and Pariante CM (2012). Lack of clinical therapeutic benefit of antidepressants is associated overall activation of the inflammatory system. Elsevier  Journal of Affective Disorders  vol. 148, (1) 136-140.  
Barbosa IG, Rybka J, Svedberg N and Carvalho LA (2012). Neuroinflammation and depression. Neuroinflammation: Pathogenesis, Mechanisms and Management  
Barbosa IG, Rocha NP, Huguet RB, Ferreira RA, Salgado JV, Carvalho LA, Pariante CM and Teixeira AL (2012). Executive dysfunction in euthymic bipolar disorder patients and its association with plasma biomarkers. Elsevier  Journal of Affective Disorders  vol. 137, (1-3) 151-155.  
Antonioli M, Rybka J and Carvalho LA (2012). Neuroimmune endocrine effects of antidepressants. Taylor & Francis  Neuropsychiatric Disease and Treatment  vol. Volume 8, 65-83.  
Jackowska M, Hamer M, Carvalho LA, Erusalimsky JD, Butcher L and Steptoe A (2012). Short Sleep Duration Is Associated with Shorter Telomere Length in Healthy Men: Findings from the Whitehall II Cohort Study. Public Library of Science (PLoS)  PLOS ONE  vol. 7, (10)  

2011

Antonioli M, Rybka J and Carvalho LA (2011). Neuroendocrinological effects of antidepressants: Is there a role for melatonin? Melatonin in the Promotion of Health: Second Edition  
Barbosa IG, Huguet RB, Sousa LP, Abreu MNS, Rocha NP, Bauer ME, Carvalho LA and Teixeira AL (2011). Circulating levels of GDNF in bipolar disorder. Elsevier  Neuroscience Letters  vol. 502, (2) 103-106.  
Anacker C, Zunszain PA, Cattaneo A, Carvalho LA, Garabedian MJ, Thuret S, Price J and Pariante CM (2011). Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Springer Nature  Molecular Psychiatry  vol. 16, (7) 738-750.  
Anacker C, Zunszain PA, Carvalho LA and Pariante CM (2011). The glucocorticoid receptor: Pivot of depression and of antidepressant treatment? Elsevier  Psychoneuroendocrinology  vol. 36, (3) 415-425.  
Weigelt K, Carvalho LA, Drexhage RC, Wijkhuijs A, de Wit H, van Beveren NJM, Birkenhäger TK, Bergink V and Drexhage HA (2011). TREM-1 and DAP12 expression in monocytes of patients with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factors. Elsevier  Brain Behavior and Immunity  vol. 25, (6) 1162-1169.  
Rybka J, Kupczyk D, Kędziora-Kornatowska K, Pawluk H, Czuczejko J, Szewczyk-Golec K, Kozakiewicz M, Antonioli M, Carvalho LA and Kędziora J (2011). Age-related changes in an antioxidant defense system in elderly patients with essential hypertension compared with healthy controls. Taylor & Francis  Redox Report  vol. 16, (2) 71-77.  
Goljevscek S and Carvalho LA (2011). Current management of obsessive and phobic states. Taylor & Francis  Neuropsychiatric Disease and Treatment  vol. Volume 7, (1) 599-610.  

2010

Rybka J, Kupczyk D, Kędziora-Kornatowska K, Motyl J, Czuczejko J, Szewczyk-Golec K, Kozakiewicz M, Pawluk H, Carvalho LA and Kędziora J (2010). Glutathione-Related Antioxidant Defense System in Elderly Patients Treated for Hypertension. Springer Nature  Cardiovascular Toxicology  vol. 11, (1) 1-9.  
Zunszain PA, Anacker C, Cattaneo A, Carvalho LA and Pariante CM (2010). Glucocorticoids, cytokines and brain abnormalities in depression. Elsevier  Progress in Neuro-Psychopharmacology and Biological Psychiatry  vol. 35, (3) 722-729.  
Carvalho LA, Garner BA, Dew T, Fazakerley H and Pariante CM (2010). Antidepressants, but not antipsychotics, modulate GR function in human whole blood: An insight into molecular mechanisms. Elsevier  European Neuropsychopharmacology  vol. 20, (6) 379-387.  

2009

Carvalho LA, Juruena MF, Papadopoulos AS, Poon L, Cleare AJ and Pariante CM (2009). Reply: ‘Clomipramine and Glucocorticoid Receptor Function’. Springer Nature  Neuropsychopharmacology  vol. 34, (9) 2194-2195.  
Markus R, Franco D, Carvalho L, Gentil V and Gorenstein C (2009). Acute increase in urinary 6-sulfatoximelatonin after clomipramine, as a predictive measure for emotional improvement. SAGE Publications  Journal of Psychopharmacology  vol. 24, (6) 855-860.  

2008

Carvalho L, Gorenstein C, Moreno R, Pariante C and Markus R (2008). Effect of antidepressants on melatonin metabolite in depressed patients. SAGE Publications  Journal of Psychopharmacology  vol. 23, (3) 315-321.  
Carvalho LA, Juruena MF, Papadopoulos AS, Poon L, Kerwin R, Cleare AJ and Pariante CM (2008). Clomipramine In Vitro Reduces Glucocorticoid Receptor Function in Healthy Subjects but not in Patients with Major Depression. Springer Nature  Neuropsychopharmacology  vol. 33, (13) 3182-3189.  
Carvalho LA and Pariante CM (2008). In vitro modulation of the glucocorticoid receptor by antidepressants. Taylor & Francis  Stress  vol. 11, (6) 411-424.  

2006

Carvalho LA, Gorenstein C, Moreno RA and Markus RP (2006). Melatonin levels in drug-free patients with major depression from the southern hemisphere. Elsevier  Psychoneuroendocrinology  vol. 31, (6) 761-768.  

2004

Reno LAC, Zago W and Markus RP (2004). Release of [3h]-l-glutamate by stimulation of nicotinic acetylcholine receptors in rat cerebellar slices. Elsevier  Neuroscience  vol. 124, (3) 647-653.  

2003

Markus RP, Santos JM, Zago W and Reno LAC (2003). Melatonin Nocturnal Surge Modulates Nicotinic Receptors and Nicotine-Induced [3H]Glutamate Release in Rat Cerebellum Slices. American Society for Pharmacology & Experimental Therapeutics (ASPET)  Journal of Pharmacology and Experimental Therapeutics  vol. 305, (2) 525-530.  

1998

Carvalho LA and Carmona-Ribeiro AM (1998). Interactions between Cationic Vesicles and Serum Proteins. American Chemical Society (ACS)  Langmuir  vol. 14, (21) 6077-6081.