Dr Livia Carvalho
Senior Lecturer in Neuropsychopharmacology
Department of Clinical Pharmacology and Precision Medicine
Queen Mary University of London
Queen Mary University of London
Research
immunology, receptor function, mental health, psychotropic drugs, biomarker development, drug effect prediction
Interests
I have over ten. years experience in culturing human blood cells and investigating receptor function with implication for mental illness and treatment. Would be interested in developing a model for immune system interaction and or blood brain barrierPublications
2024
DHEA and response to antidepressant treatment: A Mendelian Randomization analysisSouza-Teodoro LH, Davies NM, Warren HR, Andrade LHSG, Carvalho LA
Journal of Psychiatric Research, Elsevier vol. 173, 151-156.
28-02-2024
Work hours, weekend working, nonstandard work schedules and sleep quantity and quality: findings from the UK household longitudinal studyWeston G, Zilanawala A, Webb E, Carvalho L, McMunn A
Bmc Public Health, Springer Nature vol. 24 (1)
27-01-2024
2022
A systematic review and meta-analysis of the evidence on inflammation in depressive illness and symptoms in chronic and end-stage kidney diseasePsychological Medicine, Cambridge University Press (Cup) vol. 53 (12), 5839-5851.
18-10-2022
Investigating inflammation in depression in the chronically ill: Theoretical model and perspectivesThe Journal of The Royal College of Physicians of Edinburgh, Sage Publications vol. 52 (3), 247-252.
26-07-2022
Could dehydroepiandrosterone (DHEA) be a novel target for depression?Souza-Teodoro LH, Andrade LHSG, Carvalho LA
Journal of Affective Disorders Reports, Elsevier vol. 8
01-04-2022
2020
Correction: Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohortKhandaker GM, Zuber V, Rees JMB, Carvalho L, Mason AM, Foley CN, Gkatzionis A, Jones PB et al.
Molecular Psychiatry, Springer Nature vol. 26 (7), 3659-3661.
17-08-2020
Association of Anxiety With Pain and Disability but Not With Increased Measures of Inflammation in Adolescent Patients With Juvenile Idiopathic ArthritisHanns L, Radziszewska A, Suffield L, Josephs F, Chaplin H, Peckham H, Sen D, Christie D et al.
Arthritis Care & Research, Wiley vol. 72 (9), 1266-1274.
23-07-2020
2019
Effects of immunomodulatory drugs on depressive symptoms: A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disordersWittenberg GM, Stylianou A, Zhang Y, Sun Y, Gupta A, Jagannatha PS, Wang D, Hsu B et al.
Molecular Psychiatry, Springer Nature vol. 25 (6), 1275-1285.
19-08-2019
Inflammation associated with coronary heart disease predicts onset of depression in a three-year prospective follow-up: A preliminary studySforzini L, Pariante CM, Palacios JE, Tylee A, Carvalho LA, Viganò CA, Nikkheslat N
Brain Behavior and Immunity, Elsevier vol. 81, 659-664.
22-07-2019
Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohortKhandaker GM, Zuber V, Rees JMB, Carvalho L, Mason AM, Foley CN, Gkatzionis A, Jones PB et al.
Molecular Psychiatry, Springer Nature vol. 25 (7), 1477-1486.
19-03-2019
Long work hours, weekend working and depressive symptoms in men and women: findings from a UK population-based studyWeston G, Zilanawala A, Webb E, Carvalho LA, McMunn A
Journal of Epidemiology & Community Health, Bmj vol. 73 (5)
25-02-2019
2018
Self-Reported Sensory Impairments and Changes in Cognitive Performance: A Longitudinal 6-Year Follow-Up Study of English Community-Dwelling Adults Aged ⩾50 YearsLiljas AEM, Walters K, de Oliveira C, Wannamethee SG, Ramsay SE, Carvalho LA
Journal of Aging and Health, Sage Publications vol. 32 (5-6), 243-251.
06-12-2018
Does the Mediterranean Diet Protect against Stress-Induced Inflammatory Activation in European Adolescents? The HELENA StudyCarvalho KMB, Ronca DB, Michels N, Huybrechts I, Cuenca-Garcia M, Marcos A, Molnár D, Dallongeville J et al.
Nutrients, Mdpi vol. 10 (11)
15-11-2018
The effects of six-day SSRI administration on diurnal cortisol secretion in healthy volunteers.RONALDSON AL, Carvalho LA, Kostich K, Lazzarino AI, Steptoe A
Psychopharmacology, Springer Verlag vol. 235 (12), 3415-3422.
03-10-2018
Combined influence of depressive symptoms and systemic inflammation on all-cause and cardiovascular mortality: evidence for differential effects by gender in the English Longitudinal Study of AgeingLawes S, Demakakos P, Steptoe A, Lewis G, Carvalho LA
Psychological Medicine, Cambridge University Press (Cup) vol. 49 (9), 1521-1531.
17-09-2018
Psychosocial stress and inflammation driving tryptophan breakdown in children and adolescents: A cross-sectional analysis of two cohortsMichels N, Clarke G, Olavarria-Ramirez L, Gómez-Martínez S, Díaz LE, Marcos A, Widhalm K, Carvalho LA
Psychoneuroendocrinology, Elsevier vol. 94, 104-111.
21-05-2018
The effect of beta-adrenergic blockade on inflammatory and cardiovascular responses to acute mental stressSteptoe A, Ronaldson A, Kostich K, Lazzarino AI, Urbanova L, Carvalho LA
Brain, Behavior, and Immunity, Elsevier Bv vol. 70, 369-375.
01-05-2018
Depressive symptoms, pain and disability for adolescent patients with juvenile idiopathic arthritis: results from the Childhood Arthritis Prospective StudyHanns L, Cordingley L, Galloway J, Norton S, Carvalho LA, Christie D, Sen D, Carrasco R et al.
Rheumatology, Oxford University Press (Oup) vol. 57 (8), 1381-1389.
25-04-2018
2017
Self-reported vision impairment and incident prefrailty and frailty in English community-dwelling older adults: findings from a 4-year follow-up studyLiljas AEM, Carvalho LA, Papachristou E, De Oliveira C, Wannamethee SG, Ramsay SE, Walters KR
Journal of Epidemiology & Community Health, Bmj vol. 71 (11)
10-08-2017
Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adultsBell JA, Kivimäki M, Bullmore ET, Steptoe A, Carvalho LA
Translational Psychiatry, Springer Nature vol. 7 (8), e1208-e1208.
01-08-2017
Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive DisorderLeday GGR, Vértes PE, Richardson S, Greene JR, Regan T, Khan S, Henderson R, Freeman TC et al.
Biological Psychiatry, Elsevier vol. 83 (1), 70-80.
06-07-2017
Antidepressant Actions on Glucocorticoid ReceptorsNikkheslat N, Zunszain PA, Carvalho LA, Anacker C, Pariante CM
In Stress: Neuroendocrinology and Neurobiology 279-286.
13-01-2017
2016
Self‐Reported Hearing Impairment and Incident Frailty in English Community‐Dwelling Older Adults: A 4‐Year Follow‐Up StudyLiljas AEM, Carvalho LA, Papachristou E, De Oliveira C, Wannamethee SG, Ramsay SE, Walters K
Journal of The American Geriatrics Society, Wiley vol. 65 (5), 958-965.
19-12-2016
Hearing impairment and incident disability and all-cause mortality in older British community-dwelling menLiljas AEM, Wannamethee SG, Whincup PH, Papacosta O, Walters K, Iliffe S, Lennon LT, Carvalho LA et al.
Age and Ageing, Oxford University Press (Oup) vol. 45 (5), 662-667.
04-05-2016
Singing modulates mood, stress, cortisol, cytokine and neuropeptide activity in cancer patients and carersFancourt D, Williamon A, Carvalho LA, Steptoe A, Dow R, Lewis I
Ecancermedicalscience, Ecancer Global Foundation vol. 10
04-04-2016
Effects of Group Drumming Interventions on Anxiety, Depression, Social Resilience and Inflammatory Immune Response among Mental Health Service UsersFancourt D, Perkins R, Ascenso S, Carvalho LA, Steptoe A, Williamon A
Plos One, Public Library of Science (Plos) vol. 11 (3)
14-03-2016
Sensory Impairments and Cardiovascular Disease Incidence and Mortality in Older British Community‐Dwelling Men: A 10‐Year Follow‐Up StudyLiljas AEM, Wannamethee SG, Whincup PH, Papacosta O, Walters K, Iliffe S, Lennon LT, Carvalho LA et al.
Journal of The American Geriatrics Society, Wiley vol. 64 (2), 442-444.
01-02-2016
2015
Group Drumming Modulates Cytokine Response in Mental Health Services Users: A Preliminary StudyFancourt D, Perkins R, Ascenso S, Atkins L, Kilfeather S, Carvalho L, Steptoe A, Williamon A
Psychotherapy and Psychosomatics, Karger Publishers vol. 85 (1), 53-55.
27-11-2015
Higher serum dehydroepiandrosterone sulfate protects against the onset of depression in the elderly: Findings from the English Longitudinal Study of Aging (ELSA)Souza-Teodoro LH, de Oliveira C, Walters K, Carvalho LA
Psychoneuroendocrinology, Elsevier vol. 64, 40-46.
12-11-2015
Effect of short-term weight loss on mental stress-induced cardiovascular and pro-inflammatory responses in womenEndrighi R, Hamer M, Hackett RA, Carvalho LA, Jackson SE, Wardle J, Steptoe A
Stress, Taylor & Francis vol. 18 (5), 602-606.
16-07-2015
Socio-demographic characteristics, lifestyle factors and burden of morbidity associated with self-reported hearing and vision impairments in older British community-dwelling men: a cross-sectional studyLiljas AEM, Wannamethee SG, Whincup PH, Papacosta O, Walters K, Iliffe S, Lennon LT, Carvalho LA et al.
Journal of Public Health, Oxford University Press (Oup) vol. 38 (2), e21-e28.
14-07-2015
The mediation of coronary calcification in the association between risk scores and cardiac troponin T elevation in healthy adults: Is atherosclerosis a good prognostic precursor of coronary disease?Lazzarino AI, Hamer M, Carvalho L, Gaze D, Collinson P, Steptoe A
Preventive Medicine, Elsevier vol. 77, 150-154.
04-06-2015
Circulating cytotoxic T cells and natural killer cells as potential predictors for antidepressant response in melancholic depression. Restoration of T regulatory cell populations after antidepressant therapyGrosse L, Carvalho LA, Birkenhager TK, Hoogendijk WJ, Kushner SA, Drexhage HA, Bergink V
Psychopharmacology, Springer Nature vol. 233 (9), 1679-1688.
08-05-2015
Hostility and Physiological Responses to Acute Stress in People With Type 2 DiabetesHackett RA, Lazzarino AI, Carvalho LA, Hamer M, Steptoe A
, Wolters Kluwer vol. 77 (4), 458-466.
01-05-2015
Low-grade inflammation predicts persistence of depressive symptomsZalli A, Jovanova O, Hoogendijk WJG, Tiemeier H, Carvalho LA
Psychopharmacology, Springer Nature vol. 233 (9), 1669-1678.
16-04-2015
Increased percentages of regulatory T cells are associated with inflammatory and neuroendocrine responses to acute psychological stress and poorer health status in older men and womenRonaldson A, Gazali AM, Zalli A, Kaiser F, Thompson SJ, Henderson B, Steptoe A, Carvalho L
Psychopharmacology, Springer Nature vol. 233 (9), 1661-1668.
14-02-2015
Insufficient glucocorticoid signaling and elevated inflammation in coronary heart disease patients with comorbid depressionNikkheslat N, Zunszain PA, Horowitz MA, Barbosa IG, Parker JA, Myint A-M, Schwarz MJ, Tylee AT et al.
Brain Behavior and Immunity, Elsevier vol. 48, 8-18.
12-02-2015
Interplay between the Endocrine System and Immune CellsCarvalho LA, Gerdes JM, Strell C, Wallace GR, Martins JO
Biomed Research International, Hindawi vol. 2015 (1)
01-01-2015
2014
Disruption of multisystem responses to stress in type 2 diabetes: Investigating the dynamics of allostatic loadSteptoe A, Hackett RA, Lazzarino AI, Bostock S, La Marca R, Carvalho LA, Hamer M
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 111 (44), 15693-15698.
20-10-2014
Blunted glucocorticoid and mineralocorticoid sensitivity to stress in people with diabetesCarvalho LA, Urbanova L, Hamer M, Hackett RA, Lazzarino AI, Steptoe A
Psychoneuroendocrinology, Elsevier vol. 51, 209-218.
30-09-2014
Clinical characteristics of inflammation-associated depression: Monocyte gene expression is age-related in major depressive disorderGrosse L, Carvalho LA, Wijkhuijs AJM, Bellingrath S, Ruland T, Ambrée O, Alferink J, Ehring T et al.
Brain Behavior and Immunity, Elsevier vol. 44, 48-56.
20-08-2014
Corrigendum to “Interplay between the pro-oxidant and antioxidant system, and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression” [Free Rad. Bio. Med. 63C (2013) 187–194]Rybka J, Kędziora-Kornatowska K, Banaś-Leżańska P, Majsterek I, Carvalho LA, Cattaneo A, Anacker C, Kędziora J
Free Radical Biology and Medicine, Elsevier vol. 69
01-04-2014
Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resourcesZalli A, Carvalho LA, Lin J, Hamer M, Erusalimsky JD, Blackburn EH, Steptoe A
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 111 (12), 4519-4524.
10-03-2014
The relationship between cortisol responses to laboratory stress and cortisol profiles in daily lifeKidd T, Carvalho LA, Steptoe A
Biological Psychology, Elsevier vol. 99 (100), 34-40.
25-02-2014
The role of mineralocorticoid receptors in major depressive disorderPetros N, Carvalho LA
In Horizons in Neuroscience Research 204-224.
01-01-2014
Inflammatory activation is associated with a reduced glucocorticoid receptor alpha/beta expression ratio in monocytes of inpatients with melancholic major depressive disorderCarvalho LA, Bergink V, Sumaski L, Wijkhuijs J, Hoogendijk WJ, Birkenhager TK, Drexhage HA
Translational Psychiatry, Springer Nature vol. 4 (1), e344-e344.
01-01-2014
2013
Interplay between the pro-oxidant and antioxidant systems and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depressionRybka J, Kędziora-Kornatowska K, Banaś-Leżańska P, Majsterek I, Carvalho LA, Cattaneo A, Anacker C, Kędziora J
Free Radical Biology and Medicine, Elsevier vol. 63, 187-194.
23-05-2013
2012
Lack of clinical therapeutic benefit of antidepressants is associated overall activation of the inflammatory systemCarvalho LA, Torre JP, Papadopoulos AS, Poon L, Juruena MF, Markopoulou K, Cleare AJ, Pariante CM
Journal of Affective Disorders, Elsevier vol. 148 (1), 136-140.
27-11-2012
Neuroinflammation and depressionBarbosa IG, Rybka J, Svedberg N, Carvalho LA
In Neuroinflammation: Pathogenesis, Mechanisms and Management 109-126.
01-10-2012
Executive dysfunction in euthymic bipolar disorder patients and its association with plasma biomarkersBarbosa IG, Rocha NP, Huguet RB, Ferreira RA, Salgado JV, Carvalho LA, Pariante CM, Teixeira AL
Journal of Affective Disorders, Elsevier vol. 137 (1-3), 151-155.
16-01-2012
Short Sleep Duration Is Associated with Shorter Telomere Length in Healthy Men: Findings from the Whitehall II Cohort StudyJackowska M, Hamer M, Carvalho LA, Erusalimsky JD, Butcher L, Steptoe A
Plos One, Public Library of Science (Plos) vol. 7 (10)
01-01-2012
Neuroimmune endocrine effects of antidepressantsAntonioli M, Rybka J, Carvalho LA
Neuropsychiatric Disease and Treatment, Taylor & Francis vol. 8, 65-83.
01-01-2012
2011
Neuroendocrinological effects of antidepressants: Is there a role for melatonin?Antonioli M, Rybka J, Carvalho LA
In Melatonin in The Promotion of Health: Second Edition 451-470.
25-08-2011
Circulating levels of GDNF in bipolar disorderBarbosa IG, Huguet RB, Sousa LP, Abreu MNS, Rocha NP, Bauer ME, Carvalho LA, Teixeira AL
Neuroscience Letters, Elsevier vol. 502 (2), 103-106.
28-07-2011
Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptorAnacker C, Zunszain PA, Cattaneo A, Carvalho LA, Garabedian MJ, Thuret S, Price J, Pariante CM
Molecular Psychiatry, Springer Nature vol. 16 (7), 738-750.
12-04-2011
The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?Anacker C, Zunszain PA, Carvalho LA, Pariante CM
Psychoneuroendocrinology, Elsevier vol. 36 (3), 415-425.
01-04-2011
TREM-1 and DAP12 expression in monocytes of patients with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factorsWeigelt K, Carvalho LA, Drexhage RC, Wijkhuijs A, de Wit H, van Beveren NJM, Birkenhäger TK, Bergink V et al.
Brain Behavior and Immunity, Elsevier vol. 25 (6), 1162-1169.
21-03-2011
Age-related changes in an antioxidant defense system in elderly patients with essential hypertension compared with healthy controlsRybka J, Kupczyk D, Kędziora-Kornatowska K, Pawluk H, Czuczejko J, Szewczyk-Golec K, Kozakiewicz M, Antonioli M et al.
Redox Report, Taylor & Francis vol. 16 (2), 71-77.
01-03-2011
Current management of obsessive and phobic statesGoljevscek S, Carvalho LA
Neuropsychiatric Disease and Treatment, Taylor & Francis vol. 7, 599-610.
01-01-2011
2010
Glutathione-Related Antioxidant Defense System in Elderly Patients Treated for HypertensionRybka J, Kupczyk D, Kędziora-Kornatowska K, Motyl J, Czuczejko J, Szewczyk-Golec K, Kozakiewicz M, Pawluk H et al.
Cardiovascular Toxicology, Springer Nature vol. 11 (1), 1-9.
08-12-2010
Glucocorticoids, cytokines and brain abnormalities in depressionZunszain PA, Anacker C, Cattaneo A, Carvalho LA, Pariante CM
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Elsevier vol. 35 (3), 722-729.
18-04-2010
Antidepressants, but not antipsychotics, modulate GR function in human whole blood: An insight into molecular mechanismsCarvalho LA, Garner BA, Dew T, Fazakerley H, Pariante CM
European Neuropsychopharmacology, Elsevier vol. 20 (6), 379-387.
15-03-2010
2009
Reply: ‘Clomipramine and Glucocorticoid Receptor Function’Carvalho LA, Juruena MF, Papadopoulos AS, Poon L, Cleare AJ, Pariante CM
Neuropsychopharmacology, Springer Nature vol. 34 (9), 2194-2195.
13-05-2009
Acute increase in urinary 6-sulfatoximelatonin after clomipramine, as a predictive measure for emotional improvementMarkus R, Franco D, Carvalho L, Gentil V, Gorenstein C
Journal of Psychopharmacology, Sage Publications vol. 24 (6), 855-860.
05-03-2009
2008
Effect of antidepressants on melatonin metabolite in depressed patientsCarvalho L, Gorenstein C, Moreno R, Pariante C, Markus R
Journal of Psychopharmacology, Sage Publications vol. 23 (3), 315-321.
18-06-2008
Clomipramine In Vitro Reduces Glucocorticoid Receptor Function in Healthy Subjects but not in Patients with Major DepressionCarvalho LA, Juruena MF, Papadopoulos AS, Poon L, Kerwin R, Cleare AJ, Pariante CM
Neuropsychopharmacology, Springer Nature vol. 33 (13), 3182-3189.
26-03-2008
In vitro modulation of the glucocorticoid receptor by antidepressantsCarvalho LA, Pariante CM
Stress, Taylor & Francis vol. 11 (6), 411-424.
01-01-2008
2006
Melatonin levels in drug-free patients with major depression from the southern hemisphereCarvalho LA, Gorenstein C, Moreno RA, Markus RP
Psychoneuroendocrinology, Elsevier vol. 31 (6), 761-768.
18-04-2006
2004
Release of [3h]-l-glutamate by stimulation of nicotinic acetylcholine receptors in rat cerebellar slicesReno LAC, Zago W, Markus RP
Neuroscience, Elsevier vol. 124 (3), 647-653.
01-01-2004
2003
Melatonin Nocturnal Surge Modulates Nicotinic Receptors and Nicotine-Induced [3H]Glutamate Release in Rat Cerebellum SlicesMarkus RP, Santos JM, Zago W, Renó LAC
Journal of Pharmacology and Experimental Therapeutics, Elsevier vol. 305 (2), 525-530.
24-01-2003
1998
Interactions between Cationic Vesicles and Serum ProteinsCarvalho LA, Carmona-Ribeiro AM
Langmuir, American Chemical Society (Acs) vol. 14 (21), 6077-6081.
24-09-1998
Grants
Building recovery and resilience in severe mental illness: Leveraging the role of social determinants in illness trajectories and interventionsYun Fai Lau and Livia Carvalho
£1,463,807 Medical Research Council
01-04-2024 - 31-03-2029
The mechanisms underlying the antidepressant effects of physical activityLivia Carvalho
£808,500 Wellcome Trust
01-07-2023 - 30-06-2028
Dialysis Patients: depression and behavioural challengesKamaldeep Bhui and Livia Carvalho
£298,449 Barts and the London Charity
01-01-2018 - 31-12-2025