Dr Livia Carvalho
Senior Lecturer in Neuropsychopharmacology
Department of Clinical Pharmacology and Precision Medicine
QMUL
QMUL
Research
immunology, receptor function, mental health, psychotropic drugs, biomarker development, drug effect prediction
Interests
I have over ten. years experience in culturing human blood cells and investigating receptor function with implication for mental illness and treatment. Would be interested in developing a model for immune system interaction and or blood brain barrierPublications
2024
Souza-Teodoro LH, Davies NM, Warren HR, Andrade LHSG and Carvalho LA (2024). DHEA and response to antidepressant treatment: A Mendelian Randomization analysis. Elsevier Journal of Psychiatric Research 10.1016/j.jpsychires.2024.02.049
Weston G, Zilanawala A, Webb E, Carvalho L and McMunn A (2024). Work hours, weekend working, nonstandard work schedules and sleep quantity and quality: findings from the UK household longitudinal study. Springer Nature Bmc Public Health vol. 24, (1) 10.1186/s12889-024-17762-0
2022
Jayakumar S, Jennings S, Halvorsrud K, Clesse C, Yaqoob MM, Carvalho LA and Bhui K (2022). A systematic review and meta-analysis of the evidence on inflammation in depressive illness and symptoms in chronic and end-stage kidney disease. Cambridge University Press (Cup) Psychological Medicine vol. 53, (12) 5839-5851. 10.1017/s0033291722003099
Clesse C, Yaqoob MM, Jayakumar S, Bhui K and Carvalho LA (2022). Investigating inflammation in depression in the chronically ill: Theoretical model and perspectives. Sage Publications The Journal of The Royal College of Physicians of Edinburgh vol. 52, (3) 247-252. 10.1177/14782715221115776
Souza-Teodoro LH, Andrade LHSG and Carvalho LA (2022). Could dehydroepiandrosterone (DHEA) be a novel target for depression? Elsevier Journal of Affective Disorders Reports vol. 8, 10.1016/j.jadr.2022.100340
2020
Khandaker GM, Zuber V, Rees JMB, Carvalho L, Mason AM, Foley CN, Gkatzionis A, Jones PB and Burgess S (2020). Correction: Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort. Springer Nature Molecular Psychiatry vol. 26, (7) 3659-3661. 10.1038/s41380-020-0857-7
Hanns L, Radziszewska A, Suffield L, Josephs F, Chaplin H, Peckham H, Sen D, Christie D, Carvalho LA and Ioannou Y (2020). Association of Anxiety With Pain and Disability but Not With Increased Measures of Inflammation in Adolescent Patients With Juvenile Idiopathic Arthritis. Wiley Arthritis Care & Research vol. 72, (9) 1266-1274. 10.1002/acr.24006
2019
Wittenberg GM, Stylianou A, Zhang Y, Sun Y, Gupta A, Jagannatha PS, Wang D, Hsu B, Curran ME, Khan S, Chen G, Bullmore ET and Drevets WC (2019). Effects of immunomodulatory drugs on depressive symptoms: A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders. Springer Nature Molecular Psychiatry vol. 25, (6) 1275-1285. 10.1038/s41380-019-0471-8
Sforzini L, Pariante CM, Palacios JE, Tylee A, Carvalho LA, Viganò CA and Nikkheslat N (2019). Inflammation associated with coronary heart disease predicts onset of depression in a three-year prospective follow-up: A preliminary study. Elsevier Brain Behavior and Immunity vol. 81, 659-664. 10.1016/j.bbi.2019.07.023
Khandaker GM, Zuber V, Rees JMB, Carvalho L, Mason AM, Foley CN, Gkatzionis A, Jones PB and Burgess S (2019). Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort. Springer Nature Molecular Psychiatry vol. 25, (7) 1477-1486. 10.1038/s41380-019-0395-3
Weston G, Zilanawala A, Webb E, Carvalho LA and McMunn A (2019). Long work hours, weekend working and depressive symptoms in men and women: findings from a UK population-based study. Bmj Journal of Epidemiology & Community Health vol. 73, (5) 10.1136/jech-2018-211309
2018
Liljas AEM, Walters K, de Oliveira C, Wannamethee SG, Ramsay SE and Carvalho LA (2018). Self-Reported Sensory Impairments and Changes in Cognitive Performance: A Longitudinal 6-Year Follow-Up Study of English Community-Dwelling Adults Aged ⩾50 Years. Sage Publications Journal of Aging and Health vol. 32, (5-6) 243-251. 10.1177/0898264318815391
Carvalho KMB, Ronca DB, Michels N, Huybrechts I, Cuenca-Garcia M, Marcos A, Molnár D, Dallongeville J, Manios Y, Schaan BD, Moreno L, de Henauw S and Carvalho LA (2018). Does the Mediterranean Diet Protect against Stress-Induced Inflammatory Activation in European Adolescents? The HELENA Study. Mdpi Nutrients vol. 10, (11) 10.3390/nu10111770
RONALDSON AL, Carvalho LA, Kostich K, Lazzarino AI and Steptoe A (2018). The effects of six-day SSRI administration on diurnal cortisol secretion in healthy volunteers. Springer Verlag Psychopharmacology vol. 235, (12) 3415-3422. 10.1007/s00213-018-5050-1
Lawes S, Demakakos P, Steptoe A, Lewis G and Carvalho LA (2018). Combined influence of depressive symptoms and systemic inflammation on all-cause and cardiovascular mortality: evidence for differential effects by gender in the English Longitudinal Study of Ageing. Cambridge University Press (Cup) Psychological Medicine vol. 49, (9) 1521-1531. 10.1017/s003329171800209x
Michels N, Clarke G, Olavarria-Ramirez L, Gómez-Martínez S, Díaz LE, Marcos A, Widhalm K and Carvalho LA (2018). Psychosocial stress and inflammation driving tryptophan breakdown in children and adolescents: A cross-sectional analysis of two cohorts. Elsevier Psychoneuroendocrinology vol. 94, 104-111. 10.1016/j.psyneuen.2018.05.013
Steptoe A, Ronaldson A, Kostich K, Lazzarino AI, Urbanova L and Carvalho LA (2018). The effect of beta-adrenergic blockade on inflammatory and cardiovascular responses to acute mental stress. Elsevier Bv Brain, Behavior, and Immunity vol. 70, 369-375. 10.1016/j.bbi.2018.03.027
Hanns L, Cordingley L, Galloway J, Norton S, Carvalho LA, Christie D, Sen D, Carrasco R, Rashid A, Foster H, Baildam E, Chieng A, Davidson J, Wedderburn LR, Hyrich K, Thomson W and Ioannou Y (2018). Depressive symptoms, pain and disability for adolescent patients with juvenile idiopathic arthritis: results from the Childhood Arthritis Prospective Study. Oxford University Press (Oup) Rheumatology vol. 57, (8) 1381-1389. 10.1093/rheumatology/key088
2017
Liljas AEM, Carvalho LA, Papachristou E, De Oliveira C, Wannamethee SG, Ramsay SE and Walters KR (2017). Self-reported vision impairment and incident prefrailty and frailty in English community-dwelling older adults: findings from a 4-year follow-up study. Bmj Journal of Epidemiology & Community Health vol. 71, (11) 10.1136/jech-2017-209207
Bell JA, Kivimäki M, Bullmore ET, Steptoe A and Carvalho LA (2017). Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults. Springer Nature Translational Psychiatry vol. 7, (8) e1208-e1208. 10.1038/tp.2017.155
Leday GGR, Vértes PE, Richardson S, Greene JR, Regan T, Khan S, Henderson R, Freeman TC, Pariante CM, Harrison NA, Perry H, Drevets W, Wittenberg G, Bullmore E, Bullmore ET, Vertes P, Cardinal R, Leday G, Freeman T, Hume D, Wu Z, Pariante C, Cattaneo A, Zunszain P, Borsini A, Stewart R, Chandran D and Carvalho L (2017). Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder. Elsevier Biological Psychiatry vol. 83, (1) 70-80. 10.1016/j.biopsych.2017.01.021
Nikkheslat N, Zunszain PA, Carvalho LA, Anacker C and Pariante CM (2017). Antidepressant Actions on Glucocorticoid Receptors. Stress: Neuroendocrinology and Neurobiology 10.1016/B978-0-12-802175-0.00027-9
2016
Liljas AEM, Carvalho LA, Papachristou E, De Oliveira C, Wannamethee SG, Ramsay SE and Walters K (2016). Self‐Reported Hearing Impairment and Incident Frailty in English Community‐Dwelling Older Adults: A 4‐Year Follow‐Up Study. Wiley Journal of The American Geriatrics Society vol. 65, (5) 958-965. 10.1111/jgs.14687
Liljas AEM, Wannamethee SG, Whincup PH, Papacosta O, Walters K, Iliffe S, Lennon LT, Carvalho LA and Ramsay SE (2016). Hearing impairment and incident disability and all-cause mortality in older British community-dwelling men. Oxford University Press (Oup) Age and Ageing vol. 45, (5) 662-667. 10.1093/ageing/afw080
Fancourt D, Williamon A, Carvalho LA, Steptoe A, Dow R and Lewis I (2016). Singing modulates mood, stress, cortisol, cytokine and neuropeptide activity in cancer patients and carers. Ecancer Global Foundation Ecancermedicalscience vol. 10, 10.3332/ecancer.2016.631
Fancourt D, Perkins R, Ascenso S, Carvalho LA, Steptoe A and Williamon A (2016). Effects of Group Drumming Interventions on Anxiety, Depression, Social Resilience and Inflammatory Immune Response among Mental Health Service Users. Public Library of Science (Plos) Plos One vol. 11, (3) 10.1371/journal.pone.0151136
Liljas AEM, Wannamethee SG, Whincup PH, Papacosta O, Walters K, Iliffe S, Lennon LT, Carvalho LA and Ramsay SE (2016). Sensory Impairments and Cardiovascular Disease Incidence and Mortality in Older British Community‐Dwelling Men: A 10‐Year Follow‐Up Study. Wiley Journal of The American Geriatrics Society vol. 64, (2) 442-444. 10.1111/jgs.13975
2015
Fancourt D, Perkins R, Ascenso S, Atkins L, Kilfeather S, Carvalho L, Steptoe A and Williamon A (2015). Group Drumming Modulates Cytokine Response in Mental Health Services Users: A Preliminary Study. Karger Publishers Psychotherapy and Psychosomatics vol. 85, (1) 53-55. 10.1159/000431257
Souza-Teodoro LH, de Oliveira C, Walters K and Carvalho LA (2015). Higher serum dehydroepiandrosterone sulfate protects against the onset of depression in the elderly: Findings from the English Longitudinal Study of Aging (ELSA). Elsevier Psychoneuroendocrinology vol. 64, 40-46. 10.1016/j.psyneuen.2015.11.005
Endrighi R, Hamer M, Hackett RA, Carvalho LA, Jackson SE, Wardle J and Steptoe A (2015). Effect of short-term weight loss on mental stress-induced cardiovascular and pro-inflammatory responses in women. Taylor & Francis Stress vol. 18, (5) 602-606. 10.3109/10253890.2015.1064889
Liljas AEM, Wannamethee SG, Whincup PH, Papacosta O, Walters K, Iliffe S, Lennon LT, Carvalho LA and Ramsay SE (2015). Socio-demographic characteristics, lifestyle factors and burden of morbidity associated with self-reported hearing and vision impairments in older British community-dwelling men: a cross-sectional study. Oxford University Press (Oup) Journal of Public Health vol. 38, (2) e21-e28. 10.1093/pubmed/fdv095
Lazzarino AI, Hamer M, Carvalho L, Gaze D, Collinson P and Steptoe A (2015). The mediation of coronary calcification in the association between risk scores and cardiac troponin T elevation in healthy adults: Is atherosclerosis a good prognostic precursor of coronary disease? Elsevier Preventive Medicine vol. 77, 150-154. 10.1016/j.ypmed.2015.05.025
Grosse L, Carvalho LA, Birkenhager TK, Hoogendijk WJ, Kushner SA, Drexhage HA and Bergink V (2015). Circulating cytotoxic T cells and natural killer cells as potential predictors for antidepressant response in melancholic depression. Restoration of T regulatory cell populations after antidepressant therapy. Springer Nature Psychopharmacology vol. 233, (9) 1679-1688. 10.1007/s00213-015-3943-9
Hackett RA, Lazzarino AI, Carvalho LA, Hamer M and Steptoe A (2015). Hostility and Physiological Responses to Acute Stress in People With Type 2 Diabetes. Wolters Kluwer Psychosomatic Medicine vol. 77, (4) 458-466. 10.1097/psy.0000000000000172
Zalli A, Jovanova O, Hoogendijk WJG, Tiemeier H and Carvalho LA (2015). Low-grade inflammation predicts persistence of depressive symptoms. Springer Nature Psychopharmacology vol. 233, (9) 1669-1678. 10.1007/s00213-015-3919-9
Ronaldson A, Gazali AM, Zalli A, Kaiser F, Thompson SJ, Henderson B, Steptoe A and Carvalho L (2015). Increased percentages of regulatory T cells are associated with inflammatory and neuroendocrine responses to acute psychological stress and poorer health status in older men and women. Springer Nature Psychopharmacology vol. 233, (9) 1661-1668. 10.1007/s00213-015-3876-3
Nikkheslat N, Zunszain PA, Horowitz MA, Barbosa IG, Parker JA, Myint A-M, Schwarz MJ, Tylee AT, Carvalho LA and Pariante CM (2015). Insufficient glucocorticoid signaling and elevated inflammation in coronary heart disease patients with comorbid depression. Elsevier Brain Behavior and Immunity vol. 48, 8-18. 10.1016/j.bbi.2015.02.002
Carvalho LA, Gerdes JM, Strell C, Wallace GR and Martins JO (2015). Interplay between the Endocrine System and Immune Cells. Hindawi Biomed Research International vol. 2015, 10.1155/2015/986742
2014
Steptoe A, Hackett RA, Lazzarino AI, Bostock S, La Marca R, Carvalho LA and Hamer M (2014). Disruption of multisystem responses to stress in type 2 diabetes: Investigating the dynamics of allostatic load. Proceedings of The National Academy of Sciences Proceedings of The National Academy of Sciences of The United States of America vol. 111, (44) 15693-15698. 10.1073/pnas.1410401111
Carvalho LA, Urbanova L, Hamer M, Hackett RA, Lazzarino AI and Steptoe A (2014). Blunted glucocorticoid and mineralocorticoid sensitivity to stress in people with diabetes. Elsevier Psychoneuroendocrinology vol. 51, 209-218. 10.1016/j.psyneuen.2014.09.023
Grosse L, Carvalho LA, Wijkhuijs AJM, Bellingrath S, Ruland T, Ambrée O, Alferink J, Ehring T, Drexhage HA and Arolt V (2014). Clinical characteristics of inflammation-associated depression: Monocyte gene expression is age-related in major depressive disorder. Elsevier Brain Behavior and Immunity vol. 44, 48-56. 10.1016/j.bbi.2014.08.004
Rybka J, Kędziora-Kornatowska K, Banaś-Leżańska P, Majsterek I, Carvalho LA, Cattaneo A, Anacker C and Kędziora J (2014). Corrigendum to “Interplay between the pro-oxidant and antioxidant system, and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression” [Free Rad. Bio. Med. 63C (2013) 187–194]. Elsevier Free Radical Biology and Medicine vol. 69, 10.1016/j.freeradbiomed.2014.01.035
Zalli A, Carvalho LA, Lin J, Hamer M, Erusalimsky JD, Blackburn EH and Steptoe A (2014). Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources. Proceedings of The National Academy of Sciences Proceedings of The National Academy of Sciences of The United States of America vol. 111, (12) 4519-4524. 10.1073/pnas.1322145111
Kidd T, Carvalho LA and Steptoe A (2014). The relationship between cortisol responses to laboratory stress and cortisol profiles in daily life. Elsevier Biological Psychology vol. 99, (100) 34-40. 10.1016/j.biopsycho.2014.02.010
Petros N and Carvalho LA (2014). The role of mineralocorticoid receptors in major depressive disorder. Horizons in Neuroscience Research
Carvalho LA, Bergink V, Sumaski L, Wijkhuijs J, Hoogendijk WJ, Birkenhager TK and Drexhage HA (2014). Inflammatory activation is associated with a reduced glucocorticoid receptor alpha/beta expression ratio in monocytes of inpatients with melancholic major depressive disorder. Springer Nature Translational Psychiatry vol. 4, (1) e344-e344. 10.1038/tp.2013.118
2013
Rybka J, Kędziora-Kornatowska K, Banaś-Leżańska P, Majsterek I, Carvalho LA, Cattaneo A, Anacker C and Kędziora J (2013). Interplay between the pro-oxidant and antioxidant systems and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression. Elsevier Free Radical Biology and Medicine vol. 63, 187-194. 10.1016/j.freeradbiomed.2013.05.019
2012
Carvalho LA, Torre JP, Papadopoulos AS, Poon L, Juruena MF, Markopoulou K, Cleare AJ and Pariante CM (2012). Lack of clinical therapeutic benefit of antidepressants is associated overall activation of the inflammatory system. Elsevier Journal of Affective Disorders vol. 148, (1) 136-140. 10.1016/j.jad.2012.10.036
Barbosa IG, Rybka J, Svedberg N and Carvalho LA (2012). Neuroinflammation and depression. Neuroinflammation: Pathogenesis, Mechanisms and Management
Barbosa IG, Rocha NP, Huguet RB, Ferreira RA, Salgado JV, Carvalho LA, Pariante CM and Teixeira AL (2012). Executive dysfunction in euthymic bipolar disorder patients and its association with plasma biomarkers. Elsevier Journal of Affective Disorders vol. 137, (1-3) 151-155. 10.1016/j.jad.2011.12.034
Antonioli M, Rybka J and Carvalho LA (2012). Neuroimmune endocrine effects of antidepressants. Taylor & Francis Neuropsychiatric Disease and Treatment vol. Volume 8, 65-83. 10.2147/ndt.s16409
Jackowska M, Hamer M, Carvalho LA, Erusalimsky JD, Butcher L and Steptoe A (2012). Short Sleep Duration Is Associated with Shorter Telomere Length in Healthy Men: Findings from the Whitehall II Cohort Study. Public Library of Science (Plos) Plos One vol. 7, (10) 10.1371/journal.pone.0047292
2011
Antonioli M, Rybka J and Carvalho LA (2011). Neuroendocrinological effects of antidepressants: Is there a role for melatonin? Melatonin in The Promotion of Health: Second Edition
Barbosa IG, Huguet RB, Sousa LP, Abreu MNS, Rocha NP, Bauer ME, Carvalho LA and Teixeira AL (2011). Circulating levels of GDNF in bipolar disorder. Elsevier Neuroscience Letters vol. 502, (2) 103-106. 10.1016/j.neulet.2011.07.031
Anacker C, Zunszain PA, Cattaneo A, Carvalho LA, Garabedian MJ, Thuret S, Price J and Pariante CM (2011). Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Springer Nature Molecular Psychiatry vol. 16, (7) 738-750. 10.1038/mp.2011.26
Anacker C, Zunszain PA, Carvalho LA and Pariante CM (2011). The glucocorticoid receptor: Pivot of depression and of antidepressant treatment? Elsevier Psychoneuroendocrinology vol. 36, (3) 415-425. 10.1016/j.psyneuen.2010.03.007
Weigelt K, Carvalho LA, Drexhage RC, Wijkhuijs A, de Wit H, van Beveren NJM, Birkenhäger TK, Bergink V and Drexhage HA (2011). TREM-1 and DAP12 expression in monocytes of patients with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factors. Elsevier Brain Behavior and Immunity vol. 25, (6) 1162-1169. 10.1016/j.bbi.2011.03.006
Rybka J, Kupczyk D, Kędziora-Kornatowska K, Pawluk H, Czuczejko J, Szewczyk-Golec K, Kozakiewicz M, Antonioli M, Carvalho LA and Kędziora J (2011). Age-related changes in an antioxidant defense system in elderly patients with essential hypertension compared with healthy controls. Taylor & Francis Redox Report vol. 16, (2) 71-77. 10.1179/174329211x13002357050897
Goljevscek S and Carvalho LA (2011). Current management of obsessive and phobic states. Taylor & Francis Neuropsychiatric Disease and Treatment vol. Volume 7, (1) 599-610. 10.2147/ndt.s17032
2010
Rybka J, Kupczyk D, Kędziora-Kornatowska K, Motyl J, Czuczejko J, Szewczyk-Golec K, Kozakiewicz M, Pawluk H, Carvalho LA and Kędziora J (2010). Glutathione-Related Antioxidant Defense System in Elderly Patients Treated for Hypertension. Springer Nature Cardiovascular Toxicology vol. 11, (1) 1-9. 10.1007/s12012-010-9096-5
Zunszain PA, Anacker C, Cattaneo A, Carvalho LA and Pariante CM (2010). Glucocorticoids, cytokines and brain abnormalities in depression. Elsevier Progress in Neuro-Psychopharmacology and Biological Psychiatry vol. 35, (3) 722-729. 10.1016/j.pnpbp.2010.04.011
Carvalho LA, Garner BA, Dew T, Fazakerley H and Pariante CM (2010). Antidepressants, but not antipsychotics, modulate GR function in human whole blood: An insight into molecular mechanisms. Elsevier European Neuropsychopharmacology vol. 20, (6) 379-387. 10.1016/j.euroneuro.2010.02.006
2009
Carvalho LA, Juruena MF, Papadopoulos AS, Poon L, Cleare AJ and Pariante CM (2009). Reply: ‘Clomipramine and Glucocorticoid Receptor Function’. Springer Nature Neuropsychopharmacology vol. 34, (9) 2194-2195. 10.1038/npp.2009.43
Markus R, Franco D, Carvalho L, Gentil V and Gorenstein C (2009). Acute increase in urinary 6-sulfatoximelatonin after clomipramine, as a predictive measure for emotional improvement. Sage Publications Journal of Psychopharmacology vol. 24, (6) 855-860. 10.1177/0269881109102542
2008
Carvalho L, Gorenstein C, Moreno R, Pariante C and Markus R (2008). Effect of antidepressants on melatonin metabolite in depressed patients. Sage Publications Journal of Psychopharmacology vol. 23, (3) 315-321. 10.1177/0269881108089871
Carvalho LA, Juruena MF, Papadopoulos AS, Poon L, Kerwin R, Cleare AJ and Pariante CM (2008). Clomipramine In Vitro Reduces Glucocorticoid Receptor Function in Healthy Subjects but not in Patients with Major Depression. Springer Nature Neuropsychopharmacology vol. 33, (13) 3182-3189. 10.1038/npp.2008.44
Carvalho LA and Pariante CM (2008). In vitro modulation of the glucocorticoid receptor by antidepressants. Taylor & Francis Stress vol. 11, (6) 411-424. 10.1080/10253890701850759
2006
Carvalho LA, Gorenstein C, Moreno RA and Markus RP (2006). Melatonin levels in drug-free patients with major depression from the southern hemisphere. Elsevier Psychoneuroendocrinology vol. 31, (6) 761-768. 10.1016/j.psyneuen.2006.02.010
2004
Reno LAC, Zago W and Markus RP (2004). Release of [3h]-l-glutamate by stimulation of nicotinic acetylcholine receptors in rat cerebellar slices. Elsevier Neuroscience vol. 124, (3) 647-653. 10.1016/j.neuroscience.2003.12.023
2003
Markus RP, Santos JM, Zago W and Reno LAC (2003). Melatonin Nocturnal Surge Modulates Nicotinic Receptors and Nicotine-Induced [3H]Glutamate Release in Rat Cerebellum Slices. American Society For Pharmacology & Experimental Therapeutics (Aspet) Journal of Pharmacology and Experimental Therapeutics vol. 305, (2) 525-530. 10.1124/jpet.102.045625
1998
Carvalho LA and Carmona-Ribeiro AM (1998). Interactions between Cationic Vesicles and Serum Proteins. American Chemical Society (Acs) Langmuir vol. 14, (21) 6077-6081. 10.1021/la980345j