Dr Livia Carvalho

Livia Carvalho

Senior Lecturer in Neuropsychopharmacology

Department of Clinical Pharmacology and Precision Medicine
Queen Mary University of London

Research

immunology, receptor function, mental health, psychotropic drugs, biomarker development, drug effect prediction

Interests

I have over ten. years experience in culturing human blood cells and investigating receptor function with implication for mental illness and treatment. Would be interested in developing a model for immune system interaction and or blood brain barrier

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2024

DHEA and response to antidepressant treatment: A Mendelian Randomization analysis
Souza-Teodoro LH, Davies NM, Warren HR, Andrade LHSG and Carvalho LA
Journal of Psychiatric Research, Elsevier vol. 173, 151-156.  
28-02-2024
Work hours, weekend working, nonstandard work schedules and sleep quantity and quality: findings from the UK household longitudinal study
Weston G, Zilanawala A, Webb E, Carvalho L and McMunn A
Bmc Public Health, Springer Nature vol. 24 (1) 
27-01-2024

2022

A systematic review and meta-analysis of the evidence on inflammation in depressive illness and symptoms in chronic and end-stage kidney disease
Jayakumar S, Jennings S, Halvorsrud K, Clesse C, Yaqoob MM, Carvalho LA and Bhui K
Psychological Medicine, Cambridge University Press (Cup) vol. 53 (12), 5839-5851.  
18-10-2022
Investigating inflammation in depression in the chronically ill: Theoretical model and perspectives
Clesse C, Yaqoob MM, Jayakumar S, Bhui K and Carvalho LA
The Journal of The Royal College of Physicians of Edinburgh, Sage Publications vol. 52 (3), 247-252.  
26-07-2022
Could dehydroepiandrosterone (DHEA) be a novel target for depression?
Souza-Teodoro LH, Andrade LHSG and Carvalho LA
Journal of Affective Disorders Reports, Elsevier vol. 8 
01-04-2022

2020

Correction: Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort
Khandaker GM, Zuber V, Rees JMB, Carvalho L, Mason AM, Foley CN, Gkatzionis A, Jones PB and Burgess S
Molecular Psychiatry, Springer Nature vol. 26 (7), 3659-3661.  
17-08-2020
Association of Anxiety With Pain and Disability but Not With Increased Measures of Inflammation in Adolescent Patients With Juvenile Idiopathic Arthritis
Hanns L, Radziszewska A, Suffield L, Josephs F, Chaplin H, Peckham H, Sen D, Christie D, Carvalho LA and Ioannou Y
Arthritis Care & Research, Wiley vol. 72 (9), 1266-1274.  
23-07-2020

2019

Effects of immunomodulatory drugs on depressive symptoms: A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders
Wittenberg GM, Stylianou A, Zhang Y, Sun Y, Gupta A, Jagannatha PS, Wang D, Hsu B, Curran ME, Khan S, Chen G, Bullmore ET and Drevets WC
Molecular Psychiatry, Springer Nature vol. 25 (6), 1275-1285.  
19-08-2019
Inflammation associated with coronary heart disease predicts onset of depression in a three-year prospective follow-up: A preliminary study
Sforzini L, Pariante CM, Palacios JE, Tylee A, Carvalho LA, Viganò CA and Nikkheslat N
Brain Behavior and Immunity, Elsevier vol. 81, 659-664.  
22-07-2019
Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort
Khandaker GM, Zuber V, Rees JMB, Carvalho L, Mason AM, Foley CN, Gkatzionis A, Jones PB and Burgess S
Molecular Psychiatry, Springer Nature vol. 25 (7), 1477-1486.  
19-03-2019
Long work hours, weekend working and depressive symptoms in men and women: findings from a UK population-based study
Weston G, Zilanawala A, Webb E, Carvalho LA and McMunn A
Journal of Epidemiology & Community Health, Bmj vol. 73 (5) 
25-02-2019

2018

Self-Reported Sensory Impairments and Changes in Cognitive Performance: A Longitudinal 6-Year Follow-Up Study of English Community-Dwelling Adults Aged ⩾50 Years
Liljas AEM, Walters K, de Oliveira C, Wannamethee SG, Ramsay SE and Carvalho LA
Journal of Aging and Health, Sage Publications vol. 32 (5-6), 243-251.  
06-12-2018
Does the Mediterranean Diet Protect against Stress-Induced Inflammatory Activation in European Adolescents? The HELENA Study
Carvalho KMB, Ronca DB, Michels N, Huybrechts I, Cuenca-Garcia M, Marcos A, Molnár D, Dallongeville J, Manios Y, Schaan BD, Moreno L, de Henauw S and Carvalho LA
Nutrients, Mdpi vol. 10 (11) 
15-11-2018
The effects of six-day SSRI administration on diurnal cortisol secretion in healthy volunteers.
RONALDSON AL, Carvalho LA, Kostich K, Lazzarino AI and Steptoe A
Psychopharmacology, Springer Verlag vol. 235 (12), 3415-3422.  
03-10-2018
Combined influence of depressive symptoms and systemic inflammation on all-cause and cardiovascular mortality: evidence for differential effects by gender in the English Longitudinal Study of Ageing
Lawes S, Demakakos P, Steptoe A, Lewis G and Carvalho LA
Psychological Medicine, Cambridge University Press (Cup) vol. 49 (9), 1521-1531.  
17-09-2018
Psychosocial stress and inflammation driving tryptophan breakdown in children and adolescents: A cross-sectional analysis of two cohorts
Michels N, Clarke G, Olavarria-Ramirez L, Gómez-Martínez S, Díaz LE, Marcos A, Widhalm K and Carvalho LA
Psychoneuroendocrinology, Elsevier vol. 94, 104-111.  
21-05-2018
The effect of beta-adrenergic blockade on inflammatory and cardiovascular responses to acute mental stress
Steptoe A, Ronaldson A, Kostich K, Lazzarino AI, Urbanova L and Carvalho LA
Brain, Behavior, and Immunity, Elsevier Bv vol. 70, 369-375.  
01-05-2018
Depressive symptoms, pain and disability for adolescent patients with juvenile idiopathic arthritis: results from the Childhood Arthritis Prospective Study
Hanns L, Cordingley L, Galloway J, Norton S, Carvalho LA, Christie D, Sen D, Carrasco R, Rashid A, Foster H, Baildam E, Chieng A, Davidson J, Wedderburn LR, Hyrich K, Thomson W and Ioannou Y
Rheumatology, Oxford University Press (Oup) vol. 57 (8), 1381-1389.  
25-04-2018

2017

Self-reported vision impairment and incident prefrailty and frailty in English community-dwelling older adults: findings from a 4-year follow-up study
Liljas AEM, Carvalho LA, Papachristou E, De Oliveira C, Wannamethee SG, Ramsay SE and Walters KR
Journal of Epidemiology & Community Health, Bmj vol. 71 (11) 
10-08-2017
Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults
Bell JA, Kivimäki M, Bullmore ET, Steptoe A and Carvalho LA
Translational Psychiatry, Springer Nature vol. 7 (8), e1208-e1208.  
01-08-2017
Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder
Leday GGR, Vértes PE, Richardson S, Greene JR, Regan T, Khan S, Henderson R, Freeman TC, Pariante CM, Harrison NA, Perry H, Drevets W, Wittenberg G, Bullmore E, Bullmore ET, Vertes P, Cardinal R, Leday G, Freeman T, Hume D, Wu Z, Pariante C, Cattaneo A, Zunszain P, Borsini A, Stewart R, Chandran D and Carvalho L
Biological Psychiatry, Elsevier vol. 83 (1), 70-80.  
06-07-2017
Antidepressant Actions on Glucocorticoid Receptors
Nikkheslat N, Zunszain PA, Carvalho LA, Anacker C and Pariante CM
In Stress: Neuroendocrinology and Neurobiology 279-286.  
13-01-2017

2016

Self‐Reported Hearing Impairment and Incident Frailty in English Community‐Dwelling Older Adults: A 4‐Year Follow‐Up Study
Liljas AEM, Carvalho LA, Papachristou E, De Oliveira C, Wannamethee SG, Ramsay SE and Walters K
Journal of The American Geriatrics Society, Wiley vol. 65 (5), 958-965.  
19-12-2016
Hearing impairment and incident disability and all-cause mortality in older British community-dwelling men
Liljas AEM, Wannamethee SG, Whincup PH, Papacosta O, Walters K, Iliffe S, Lennon LT, Carvalho LA and Ramsay SE
Age and Ageing, Oxford University Press (Oup) vol. 45 (5), 662-667.  
04-05-2016
Singing modulates mood, stress, cortisol, cytokine and neuropeptide activity in cancer patients and carers
Fancourt D, Williamon A, Carvalho LA, Steptoe A, Dow R and Lewis I
Ecancermedicalscience, Ecancer Global Foundation vol. 10 
04-04-2016
Effects of Group Drumming Interventions on Anxiety, Depression, Social Resilience and Inflammatory Immune Response among Mental Health Service Users
Fancourt D, Perkins R, Ascenso S, Carvalho LA, Steptoe A and Williamon A
Plos One, Public Library of Science (Plos) vol. 11 (3) 
14-03-2016
Sensory Impairments and Cardiovascular Disease Incidence and Mortality in Older British Community‐Dwelling Men: A 10‐Year Follow‐Up Study
Liljas AEM, Wannamethee SG, Whincup PH, Papacosta O, Walters K, Iliffe S, Lennon LT, Carvalho LA and Ramsay SE
Journal of The American Geriatrics Society, Wiley vol. 64 (2), 442-444.  
01-02-2016

2015

Group Drumming Modulates Cytokine Response in Mental Health Services Users: A Preliminary Study
Fancourt D, Perkins R, Ascenso S, Atkins L, Kilfeather S, Carvalho L, Steptoe A and Williamon A
Psychotherapy and Psychosomatics, Karger Publishers vol. 85 (1), 53-55.  
27-11-2015
Higher serum dehydroepiandrosterone sulfate protects against the onset of depression in the elderly: Findings from the English Longitudinal Study of Aging (ELSA)
Souza-Teodoro LH, de Oliveira C, Walters K and Carvalho LA
Psychoneuroendocrinology, Elsevier vol. 64, 40-46.  
12-11-2015
Effect of short-term weight loss on mental stress-induced cardiovascular and pro-inflammatory responses in women
Endrighi R, Hamer M, Hackett RA, Carvalho LA, Jackson SE, Wardle J and Steptoe A
Stress, Taylor & Francis vol. 18 (5), 602-606.  
16-07-2015
Socio-demographic characteristics, lifestyle factors and burden of morbidity associated with self-reported hearing and vision impairments in older British community-dwelling men: a cross-sectional study
Liljas AEM, Wannamethee SG, Whincup PH, Papacosta O, Walters K, Iliffe S, Lennon LT, Carvalho LA and Ramsay SE
Journal of Public Health, Oxford University Press (Oup) vol. 38 (2), e21-e28.  
14-07-2015
The mediation of coronary calcification in the association between risk scores and cardiac troponin T elevation in healthy adults: Is atherosclerosis a good prognostic precursor of coronary disease?
Lazzarino AI, Hamer M, Carvalho L, Gaze D, Collinson P and Steptoe A
Preventive Medicine, Elsevier vol. 77, 150-154.  
04-06-2015
Circulating cytotoxic T cells and natural killer cells as potential predictors for antidepressant response in melancholic depression. Restoration of T regulatory cell populations after antidepressant therapy
Grosse L, Carvalho LA, Birkenhager TK, Hoogendijk WJ, Kushner SA, Drexhage HA and Bergink V
Psychopharmacology, Springer Nature vol. 233 (9), 1679-1688.  
08-05-2015
Hostility and Physiological Responses to Acute Stress in People With Type 2 Diabetes
Hackett RA, Lazzarino AI, Carvalho LA, Hamer M and Steptoe A
Psychosomatic Medicine, Wolters Kluwer vol. 77 (4), 458-466.  
01-05-2015
Low-grade inflammation predicts persistence of depressive symptoms
Zalli A, Jovanova O, Hoogendijk WJG, Tiemeier H and Carvalho LA
Psychopharmacology, Springer Nature vol. 233 (9), 1669-1678.  
16-04-2015
Increased percentages of regulatory T cells are associated with inflammatory and neuroendocrine responses to acute psychological stress and poorer health status in older men and women
Ronaldson A, Gazali AM, Zalli A, Kaiser F, Thompson SJ, Henderson B, Steptoe A and Carvalho L
Psychopharmacology, Springer Nature vol. 233 (9), 1661-1668.  
14-02-2015
Insufficient glucocorticoid signaling and elevated inflammation in coronary heart disease patients with comorbid depression
Nikkheslat N, Zunszain PA, Horowitz MA, Barbosa IG, Parker JA, Myint A-M, Schwarz MJ, Tylee AT, Carvalho LA and Pariante CM
Brain Behavior and Immunity, Elsevier vol. 48, 8-18.  
12-02-2015
Interplay between the Endocrine System and Immune Cells
Carvalho LA, Gerdes JM, Strell C, Wallace GR and Martins JO
Biomed Research International, Hindawi vol. 2015 (1) 
01-01-2015

2014

Disruption of multisystem responses to stress in type 2 diabetes: Investigating the dynamics of allostatic load
Steptoe A, Hackett RA, Lazzarino AI, Bostock S, La Marca R, Carvalho LA and Hamer M
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 111 (44), 15693-15698.  
20-10-2014
Blunted glucocorticoid and mineralocorticoid sensitivity to stress in people with diabetes
Carvalho LA, Urbanova L, Hamer M, Hackett RA, Lazzarino AI and Steptoe A
Psychoneuroendocrinology, Elsevier vol. 51, 209-218.  
30-09-2014
Clinical characteristics of inflammation-associated depression: Monocyte gene expression is age-related in major depressive disorder
Grosse L, Carvalho LA, Wijkhuijs AJM, Bellingrath S, Ruland T, Ambrée O, Alferink J, Ehring T, Drexhage HA and Arolt V
Brain Behavior and Immunity, Elsevier vol. 44, 48-56.  
20-08-2014
Corrigendum to “Interplay between the pro-oxidant and antioxidant system, and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression” [Free Rad. Bio. Med. 63C (2013) 187–194]
Rybka J, Kędziora-Kornatowska K, Banaś-Leżańska P, Majsterek I, Carvalho LA, Cattaneo A, Anacker C and Kędziora J
Free Radical Biology and Medicine, Elsevier vol. 69 
01-04-2014
Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources
Zalli A, Carvalho LA, Lin J, Hamer M, Erusalimsky JD, Blackburn EH and Steptoe A
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 111 (12), 4519-4524.  
10-03-2014
The relationship between cortisol responses to laboratory stress and cortisol profiles in daily life
Kidd T, Carvalho LA and Steptoe A
Biological Psychology, Elsevier vol. 99 (100), 34-40.  
25-02-2014
The role of mineralocorticoid receptors in major depressive disorder
Petros N and Carvalho LA
In Horizons in Neuroscience Research 204-224.  
01-01-2014
Inflammatory activation is associated with a reduced glucocorticoid receptor alpha/beta expression ratio in monocytes of inpatients with melancholic major depressive disorder
Carvalho LA, Bergink V, Sumaski L, Wijkhuijs J, Hoogendijk WJ, Birkenhager TK and Drexhage HA
Translational Psychiatry, Springer Nature vol. 4 (1), e344-e344.  
01-01-2014

2013

Interplay between the pro-oxidant and antioxidant systems and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression
Rybka J, Kędziora-Kornatowska K, Banaś-Leżańska P, Majsterek I, Carvalho LA, Cattaneo A, Anacker C and Kędziora J
Free Radical Biology and Medicine, Elsevier vol. 63, 187-194.  
23-05-2013

2012

Lack of clinical therapeutic benefit of antidepressants is associated overall activation of the inflammatory system
Carvalho LA, Torre JP, Papadopoulos AS, Poon L, Juruena MF, Markopoulou K, Cleare AJ and Pariante CM
Journal of Affective Disorders, Elsevier vol. 148 (1), 136-140.  
27-11-2012
Neuroinflammation and depression
Barbosa IG, Rybka J, Svedberg N and Carvalho LA
In Neuroinflammation: Pathogenesis, Mechanisms and Management 109-126.  
01-10-2012
Executive dysfunction in euthymic bipolar disorder patients and its association with plasma biomarkers
Barbosa IG, Rocha NP, Huguet RB, Ferreira RA, Salgado JV, Carvalho LA, Pariante CM and Teixeira AL
Journal of Affective Disorders, Elsevier vol. 137 (1-3), 151-155.  
16-01-2012
Neuroimmune endocrine effects of antidepressants
Antonioli M, Rybka J and Carvalho LA
Neuropsychiatric Disease and Treatment, Taylor & Francis vol. Volume 8, 65-83.  
01-01-2012
Short Sleep Duration Is Associated with Shorter Telomere Length in Healthy Men: Findings from the Whitehall II Cohort Study
Jackowska M, Hamer M, Carvalho LA, Erusalimsky JD, Butcher L and Steptoe A
Plos One, Public Library of Science (Plos) vol. 7 (10) 
01-01-2012

2011

Neuroendocrinological effects of antidepressants: Is there a role for melatonin?
Antonioli M, Rybka J and Carvalho LA
In Melatonin in The Promotion of Health: Second Edition 451-470.  
25-08-2011
Circulating levels of GDNF in bipolar disorder
Barbosa IG, Huguet RB, Sousa LP, Abreu MNS, Rocha NP, Bauer ME, Carvalho LA and Teixeira AL
Neuroscience Letters, Elsevier vol. 502 (2), 103-106.  
28-07-2011
Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor
Anacker C, Zunszain PA, Cattaneo A, Carvalho LA, Garabedian MJ, Thuret S, Price J and Pariante CM
Molecular Psychiatry, Springer Nature vol. 16 (7), 738-750.  
12-04-2011
The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?
Anacker C, Zunszain PA, Carvalho LA and Pariante CM
Psychoneuroendocrinology, Elsevier vol. 36 (3), 415-425.  
01-04-2011
TREM-1 and DAP12 expression in monocytes of patients with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factors
Weigelt K, Carvalho LA, Drexhage RC, Wijkhuijs A, de Wit H, van Beveren NJM, Birkenhäger TK, Bergink V and Drexhage HA
Brain Behavior and Immunity, Elsevier vol. 25 (6), 1162-1169.  
21-03-2011
Age-related changes in an antioxidant defense system in elderly patients with essential hypertension compared with healthy controls
Rybka J, Kupczyk D, Kędziora-Kornatowska K, Pawluk H, Czuczejko J, Szewczyk-Golec K, Kozakiewicz M, Antonioli M, Carvalho LA and Kędziora J
Redox Report, Taylor & Francis vol. 16 (2), 71-77.  
01-03-2011
Current management of obsessive and phobic states
Goljevscek S and Carvalho LA
Neuropsychiatric Disease and Treatment, Taylor & Francis vol. Volume 7 (1), 599-610.  
01-01-2011

2010

Glutathione-Related Antioxidant Defense System in Elderly Patients Treated for Hypertension
Rybka J, Kupczyk D, Kędziora-Kornatowska K, Motyl J, Czuczejko J, Szewczyk-Golec K, Kozakiewicz M, Pawluk H, Carvalho LA and Kędziora J
Cardiovascular Toxicology, Springer Nature vol. 11 (1), 1-9.  
08-12-2010
Glucocorticoids, cytokines and brain abnormalities in depression
Zunszain PA, Anacker C, Cattaneo A, Carvalho LA and Pariante CM
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Elsevier vol. 35 (3), 722-729.  
18-04-2010
Antidepressants, but not antipsychotics, modulate GR function in human whole blood: An insight into molecular mechanisms
Carvalho LA, Garner BA, Dew T, Fazakerley H and Pariante CM
European Neuropsychopharmacology, Elsevier vol. 20 (6), 379-387.  
15-03-2010

2009

Reply: ‘Clomipramine and Glucocorticoid Receptor Function’
Carvalho LA, Juruena MF, Papadopoulos AS, Poon L, Cleare AJ and Pariante CM
Neuropsychopharmacology, Springer Nature vol. 34 (9), 2194-2195.  
13-05-2009
Acute increase in urinary 6-sulfatoximelatonin after clomipramine, as a predictive measure for emotional improvement
Markus R, Franco D, Carvalho L, Gentil V and Gorenstein C
Journal of Psychopharmacology, Sage Publications vol. 24 (6), 855-860.  
05-03-2009

2008

Effect of antidepressants on melatonin metabolite in depressed patients
Carvalho L, Gorenstein C, Moreno R, Pariante C and Markus R
Journal of Psychopharmacology, Sage Publications vol. 23 (3), 315-321.  
18-06-2008
Clomipramine In Vitro Reduces Glucocorticoid Receptor Function in Healthy Subjects but not in Patients with Major Depression
Carvalho LA, Juruena MF, Papadopoulos AS, Poon L, Kerwin R, Cleare AJ and Pariante CM
Neuropsychopharmacology, Springer Nature vol. 33 (13), 3182-3189.  
26-03-2008
In vitro modulation of the glucocorticoid receptor by antidepressants
Carvalho LA and Pariante CM
Stress, Taylor & Francis vol. 11 (6), 411-424.  
01-01-2008

2006

Melatonin levels in drug-free patients with major depression from the southern hemisphere
Carvalho LA, Gorenstein C, Moreno RA and Markus RP
Psychoneuroendocrinology, Elsevier vol. 31 (6), 761-768.  
18-04-2006

2004

Release of [3h]-l-glutamate by stimulation of nicotinic acetylcholine receptors in rat cerebellar slices
Reno LAC, Zago W and Markus RP
Neuroscience, Elsevier vol. 124 (3), 647-653.  
01-01-2004

2003

Melatonin Nocturnal Surge Modulates Nicotinic Receptors and Nicotine-Induced [3H]Glutamate Release in Rat Cerebellum Slices
Markus RP, Santos JM, Zago W and Reno LAC
Journal of Pharmacology and Experimental Therapeutics, Elsevier vol. 305 (2), 525-530.  
24-01-2003

1998

Interactions between Cationic Vesicles and Serum Proteins
Carvalho LA and Carmona-Ribeiro AM
Langmuir, American Chemical Society (Acs) vol. 14 (21), 6077-6081.  
24-09-1998

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconThe mechanisms underlying the antidepressant effects of physical activity
Livia Carvalho
£808,500 Wellcome Trust
01-07-2023 - 30-06-2028
bullet iconDialysis Patients: depression and behavioural challenges
Kamaldeep Bhui and Livia Carvalho
£298,449 Barts and the London Charity
01-01-2018 - 31-03-2025