Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues
Rolas L, Stein M, Barkaway A, Reglero-Real N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L, Golding M, Blacksell IA, Giblin MJ, Jaworska E, Bishop CL, Voisin M-B, Gaston-Massuet C, Fossati-Jimack L, Pitzalis C, Cooper D, Nightingale TD, Lopez-Otin C, Lewis MJ and Nourshargh S
Embo Reports, Springer Nature vol. 25 (9), 3842-3869.  
25-06-2024

Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response
Corsiero E, Caliste M, Jagemann L, Fossati-Jimack L, Goldmann K, Cubuk C, Ghirardi GM, Prediletto E, Rivellese F, Alessandri C, Hopkinson M, Javaheri B, Pitsillides AA, Lewis MJ, Pitzalis C and Bombardieri M
Journal of Clinical Investigation, American Society For Clinical Investigation vol. 134 (12) 
30-04-2024

Serum and Tissue Biomarkers Associated With Composite of Relevant Endpoints for Sjögren Syndrome (CRESS) and Sjögren Tool for Assessing Response (STAR) to B Cell–Targeted Therapy in the Trial of Anti–B Cell Therapy in Patients With Primary Sjögren Syndrome (TRACTISS)
Pontarini E, Sciacca E, Chowdhury F, Grigoriadou S, Rivellese F, Murray‐Brown WJ, Lucchesi D, Fossati‐Jimack L, Nerviani A, Jaworska E, Ghirardi GM, Giacomassi C, Emery P, Ng WF, Sutcliffe N, Everett C, Fernandez C, Tappuni A, Seror R, Mariette X, Porcher R, Cavallaro G, Pulvirenti A, Verstappen GM, de Wolff L, Arends S, Bootsma H, Lewis MJ, Pitzalis C and Bowman SJ
Arthritis & Rheumatology, Wiley vol. 76 (5), 763-776.  
15-02-2024

Phosphoproteomic profiling of early rheumatoid arthritis synovium reveals active signalling pathways and differentiates inflammatory pathotypes
Çubuk C, Lau R, Cutillas P, Rajeeve V, John CR, Surace AEA, Hands R, Fossati-Jimack L, Lewis MJ and Pitzalis C
Arthritis Research & Therapy, Springer Nature vol. 26 (1) 
01-01-2024

Comparative analysis of late-stage rheumatoid arthritis and osteoarthritis reveals shared histopathological features
Boutet M-A, Nerviani A, Fossati-Jimack L, Hands-Greenwood R, Ahmed M, Rivellese F and Pitzalis C
Osteoarthritis and Cartilage, Elsevier vol. 32 (2), 166-176.  
19-11-2023

AB0067 MODE OF ACTION AND TARGET INVESTIGATION OF THE NEW ANTI-RHEUMATIC DRUG RABEXIMOD.
Ghirardi GM, Nerviani A, Fossati-Jimack L, Pontarini E, Italiani P, Pratesi F, Abdelmoaty S, Högerkorp C and Pitzalis C
, Bmj, 1212.2-121213.  
30-05-2023

Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis
Shikh MEME, Sayed RE, Aly NAR, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis MJ and Pitzalis C
Frontiers in Medicine, Frontiers vol. 9 
16-11-2022

Rituximab versus tocilizumab and B-cell status in TNF-alpha inadequate-responder rheumatoid arthritis patients:the R4-RA RCT
Humby F, Durez P, Buch MH, Lewis MJ, Bombardieri M, John C, Rizvi H, Warren L, Peel J, Fossati-Jimack L, Hands RE, Giorli G, Rivellese F, Cañete JD, Taylor PC, Sasieni P, Fonseca JE, Choy E and Pitzalis C
Efficacy and Mechanism Evaluation, National Institute For Health and Care Research vol. 9 (7), 1-58.  
01-08-2022

Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming
Cooles FAH, Tarn J, Lendrem DW, Naamane N, Lin CM, Millar B, Maney NJ, Anderson AE, Thalayasingam N, Diboll J, Bondet V, Duffy D, Barnes MR, Smith GR, Ng S, Watson D, Henkin R, Cope AP, Reynard LN, Pratt AG, Isaacs JD, Hughes-Morley A, Walker A, Cuza A, Gallagher-Syed A, Anderson A, Haynes A, Filer A and Long A
Annals of The Rheumatic Diseases, Elsevier vol. 81 (9), 1214-1223.  
09-06-2022

POS0431 PDGF-BB, TNF-α, AND LT-β REGULATE FOLLICULAR DENDRITIC CELL DEVELOPMENT IN THE RHEUMATOID SYNOVIUM
Elshikh M, El Sayed R, Aly N, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis M and Pitzalis C
Annals of The Rheumatic Diseases, Elsevier vol. 81 (Suppl 1), 470.1-47470.  
23-05-2022

OP0077 SYNOVIAL RNA-SEQ ANALYSIS OF THE R4RA TRIAL IDENTIFIES SIGNATURES OF TREATMENT RESISTANCE AND REFRACTORY STATE IN RHEUMATOID ARTHRITIS
Surace A, Sciacca E, Goldmann K, Rivellese F, Cubuk C, Giorli G, Fossati-Jimack L, Ahmed M, Prediletto E, Bombardieri M, Lewis M and Pitzalis C
Annals of The Rheumatic Diseases, Elsevier vol. 81 (Suppl 1), 52.2-5253.  
23-05-2022

OP0085 CELL LINEAGE-SPECIFIC TRANSCRIPT DECONVOLUTION OF SYNOVIAL BIOPSIES FROM THE R4RA TRIAL IDENTIFIES CELL POPULATIONS ASSOCIATED WITH RESPONSE TO RITUXIMAB AND TOCILIZUMAB
Rivellese F, Cubuk C, Surace A, Goldmann K, Sciacca E, Giorli G, Nerviani A, Fossati-Jimack L, Thorborn G, Bombardieri M, Barnes M, Lewis M and Pitzalis C
Annals of The Rheumatic Diseases, Elsevier vol. 81 (Suppl 1), 56.2-5657.  
23-05-2022

RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients
Isaacs JD, Brockbank S, Pedersen AW, Hilkens C, Anderson A, Stocks P, Lendrem D, Tarn J, Smith GR, Allen B, Casement J, Diboll J, Harry R, Cooles FAH, Cope AP, Simpson G, Toward R, Noble H, Parke A, Wu , Clarke F, Scott D, Scott IC, Galloway J, Lempp H, Ibrahim F, Schwank S, Molyneux G, Lazarov T and Geissmann F
Scientific Data, Springer Nature vol. 9 (1) 
09-05-2022

OP0136 RITUXIMAB PREVENTS THE PROGRESSION OF B-CELL DRIVEN INFLAMMATORY INFILTRATE IN THE MINOR SALIVARY GLANDS OF PRIMARY SJOGREN’S SYNDROME BY DOWNREGULATING IMMUNOLOGICAL PATHWAYS KEY IN ECTOPIC GERMINAL CENTRE ORGANIZATION: RESULTS FROM THE TRACTISS TRIAL
Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Goldmann K, Fossati-Jimack L, Emery P, Ng WF, Sutcliffe N, Everett C, Fernandez C, Tappuni A, Lewis M, Pitzalis C, Bowman SJ and Bombardieri M
Annals of The Rheumatic Diseases vol. 80 (Suppl 1), 79-80.  
17-09-2021

NKp30 Receptor Upregulation in Salivary Glands of Sjögren’s Syndrome Characterizes Ectopic Lymphoid Structures and Is Restricted by Rituximab Treatment
Pontarini E, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Fossati-Jimack L, Coleby R, Chowdhury F, Calcaterra F, Tappuni A, Lewis MJ, Fabris M, Quartuccio L, Della Bella S, Bowman S, Pitzalis C, Mavilio D, De Vita S and Bombardieri M
Frontiers in Immunology, Frontiers vol. 12 
14-09-2021

OP0011 INTEGRATION OF FLOW AND DIGITAL CYTOMETRY IN EARLY TREATMENT-NAÏVE RHEUMATOID ARTHRITIS IDENTIFIES DISTINCT IMMUNOPHENOTYPES IN PERIPHERAL BLOOD AND DISEASE TISSUE
Rivellese F, Pontarini E, Fossati-Jimack L, Moura RA, Romão VC, Fonseca JE, Nerviani A, Cubuk C, Goldmann K, Bombardieri M, Lewis M and Pitzalis C
Annals of The Rheumatic Diseases, Elsevier vol. 80 (Suppl 1), 7.2-7.7.  
19-05-2021

Novel Bispecific Antibody for Synovial-Specific Target Delivery of Anti-TNF Therapy in Rheumatoid Arthritis
Ferrari M, Onuoha SC, Fossati-Jimack L, Nerviani A, Alves PL, Pagani S, Deantonio C, Colombo F, Santoro C, Sblattero D and Pitzalis C
Frontiers in Immunology vol. 12 
19-02-2021

Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial
Humby F, Durez P, Buch MH, Lewis MJ, Rizvi H, Rivellese F, Nerviani A, Giorli G, Mahto A, Montecucco C, Lauwerys B, Ng N, Ho P, Bombardieri M, Romão VC, Verschueren P, Kelly S, Sainaghi PP, Gendi N, Dasgupta B, Cauli A, Reynolds P, Cañete JD, Moots R, Taylor PC, Edwards CJ, Isaacs J, Sasieni P, Choy E and Pitzalis C
The Lancet, Elsevier vol. 397 (10271), 305-317.  
01-01-2021

Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren’s syndrome with ectopic germinal centres and MALT lymphoma
Pontarini E, Murray-Brown WJ, Croia C, Lucchesi D, Conway J, Rivellese F, Fossati-Jimack L, Astorri E, Prediletto E, Corsiero E, Delvecchio FR, Coleby R, Gelbhardt E, Bono A, Baldini C, Puxeddu I, Ruscitti P, Giacomelli R, Barone F, Fisher B, Bowman SJ, Colafrancesco S, Priori R, Sutcliffe N, Challacombe S, Carlesso G, Tappuni A, Pitzalis C and Bombardieri M
Annals of The Rheumatic Diseases, Elsevier vol. 79 (12), 1588-1599.  
22-09-2020

C3 Drives Inflammatory Skin Carcinogenesis Independently of C5
Jackson WD, Gulino A, Fossati-Jimack L, Seoane RC, Tian K, Best K, Köhl J, Belmonte B, Strid J and Botto M
Journal of Investigative Dermatology, Elsevier vol. 141 (Immunobiology 209 7 ), 404-414.e6.  
16-07-2020

P233 B cell-rich synovitis in early and established rheumatoid arthritis
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands R, Giorli G, Frias B, Thornborn G, Jaworska E, John C, Goldmann K, Lewis M, Manzo A, Bombardieri M, Pitzalis C, investigators P and investigators R
Rheumatology vol. 59 (Supplement_2) 
01-04-2020

B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure.
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C and PEAC- R4RA investigators
Arthritis and Rheumatology, Wiley 
17-03-2020

Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis
El Shikh MEM, El Sayed R, Nerviani A, Goldmann K, John CR, Hands R, Fossati-Jimack L, Lewis MJ and Pitzalis C
Journal of Autoimmunity, Elsevier Bv 
01-07-2019

NK cell recruitment in salivary glands provides early viral control but is dispensable for tertiary lymphoid structure formation
Pontarini E, Lucchesi D, Fossati-Jimack L, Coleby R, Tentorio P, Croia C, Bombardieri M and Mavilio D
Journal of Leukocyte Biology, Oxford University Press (Oup) vol. 105 (3), 589-602.  
21-12-2018

The RA-MAP Consortium: a working model for academia-industry collaboration.
Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA, Goodyear CS, Emery P, Ehrenstein MR, Gozzard N, Harris R, Hollis S, Keidel S, Levesque M, Lindholm C, McDermott MF, McInnes IB, Mela CM, Parker G, Read S, Pedersen AW, Ponchel F, Porter D, Rao R, Rowe A, Schulz-Knappe P, Sleeman MA and Symmons D
Nat Rev Rheumatol vol. 14 (1), 53-60.  
07-12-2018

Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production
Rivellese F, Mauro D, Nerviani A, Pagani S, Fossati-Jimack L, Messemaker T, Kurreeman FAS, Toes REM, Ramming A, Rauber S, Schett G, Jones GW, Jones SA, Rossi FW, de Paulis A, Marone G, Shikh MEME, Humby F and Pitzalis C
Annals of The Rheumatic Diseases, Elsevier vol. 77 (12) 
20-08-2018

Complement receptor 3 mediates renal protection in experimental C3 glomerulopathy
Barbour TD, Ling GS, Ruseva MM, Fossati-Jimack L, Cook HT, Botto M and Pickering MC
Kidney International, Elsevier vol. 89 (4), 823-832.  
03-02-2016

Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1low Monocytes
Saja MF, Baudino L, Jackson WD, Cook HT, Malik TH, Fossati-Jimack L, Ruseva M, Pickering MC, Woollard KJ and Botto M
Cell Reports, Elsevier vol. 12 (11), 1802-1815.  
01-09-2015

Intranasal peptide‐induced tolerance and linked suppression: consequences of complement deficiency
Fossati-Jimack L, Ling GS, Baudino L, Szajna M, Manivannan K, Zhao JC, Midgley R, Chai J-G, Simpson E, Botto M and Scott D
Immunology, Wiley vol. 144 (1), 149-157.  
08-12-2014

Mechanisms of complement activation by dextran-coated superparamagnetic iron oxide (SPIO) nanoworms in mouse versus human serum
Banda NK, Mehta G, Chao Y, Wang G, Inturi S, Fossati-Jimack L, Botto M, Wu L, Moghimi SM and Simberg D
Particle and Fibre Toxicology, Springer Nature vol. 11 (1) 
26-11-2014

IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut
Sattler S, Ling G-S, Xu D, Hussaarts L, Romaine A, Zhao H, Fossati-Jimack L, Malik T, Cook HT, Botto M, Lau Y-L, Smits HH, Liew FY and Huang F-P
Journal of Autoimmunity, Elsevier vol. 50 (100), 107-122.  
01-02-2014

C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens
Baudino L, Sardini A, Ruseva MM, Fossati-Jimack L, Cook HT, Scott D, Simpson E and Botto M
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 111 (4), 1503-1508.  
13-01-2014

Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages
Ling GS, Bennett J, Woollard KJ, Szajna M, Fossati-Jimack L, Taylor PR, Scott D, Franzoso G, Cook HT and Botto M
Nature Communications, Springer Nature vol. 5 (1) 
01-01-2014

Phagocytosis Is the Main CR3-Mediated Function Affected by the Lupus-Associated Variant of CD11b in Human Myeloid Cells
Fossati-Jimack L, Ling GS, Cortini A, Szajna M, Malik TH, McDonald JU, Pickering MC, Cook HT, Taylor PR and Botto M
Plos One, Public Library of Science (Plos) vol. 8 (2) 
01-01-2013

Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia
Lewis MJ, Malik TH, Fossati‐Jimack L, Carassiti D, Cook HT, Haskard DO and Botto M
Arthritis & Rheumatism, Wiley vol. 64 (8), 2707-2718.  
27-07-2012

Mice with defective Fas ligand are protected from crescentic glomerulonephritis
Tarzi RM, Sharp PEH, McDaid JP, Fossati-Jimack L, Herbert PE, Pusey CD, Cook HT and Warrens AN
Kidney International, Elsevier vol. 81 (2), 170-178.  
14-09-2011

In vivo functional analysis and genetic modification of in vitro‐derived mouse neutrophils
McDonald JU, Cortini A, Rosas M, Fossati‐Jimack L, Ling GS, Lewis KJ, Dewitt S, Liddiard K, Brown GD, Jones SA, Hallett MB, Botto M and Taylor PR
The Faseb Journal, Wiley vol. 25 (6), 1972-1982.  
02-03-2011

Identification and Characterization of a Lupus Suppressor 129 Locus on Chromosome 3
Carlucci F, Fossati-Jimack L, Dumitriu IE, Heidari Y, Walport MJ, Szajna M, Baruah P, Garden OA, Cook HT and Botto M
The Journal of Immunology, The American Association of Immunologists vol. 184 (11), 6256-6265.  
01-06-2010

Evidence that Yaa-induced loss of marginal zone B cells is a result of dendritic cell-mediated enhanced activation
Santiago-Raber M-L, Amano H, Amano E, Fossati-Jimack L, Swee LK, Rolink A and Izui S
Journal of Autoimmunity, Elsevier vol. 34 (4), 349-355.  
10-02-2010

A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice
Heidari Y, Fossati-Jimack L, Carlucci F, Walport MJ, Cook HT and Botto M
Genes & Immunity, Springer Nature vol. 10 (1), 47-55.  
09-10-2008

Dissection of Genetic Mechanisms Governing the Expression of Serum Retroviral gp70 Implicated in Murine Lupus Nephritis
Baudino L, Yoshinobu K, Morito N, Kikuchi S, Fossati-Jimack L, Morley BJ, Vyse TJ, Hirose S, Jørgensen TN, Tucker RM, Roark CL, Kotzin BL, Evans LH and Izui S
The Journal of Immunology, The American Association of Immunologists vol. 181 (4), 2846-2854.  
15-08-2008

CD4+ T cells play a major role for IgM and IgG anti-DNA production in mice infected with Plasmodium yoelii
Fossati L, Merino J and Izui S
Clinical & Experimental Immunology, Oxford University Press (Oup) vol. 79 (2), 291-296.  
28-06-2008

Regulation of B cell tolerance by 129‐derived chromosome 1 loci in C57BL/6 mice
Fossati‐Jimack L, Cortes‐Hernandez J, Norsworthy PJ, Cook HT, Walport MJ and Botto M
Arthritis & Rheumatism, Wiley vol. 58 (7), 2131-2141.  
24-06-2008

C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice
Fossati-Jimack L, Cortes-Hernandez J, Norsworthy PJ, Walport MJ, Cook HT and Botto M
Molecular Immunology, Elsevier vol. 45 (3), 787-795.  
01-08-2007

IgM and IgA anti-erythrocyte autoantibodies induce anemia in a mouse model through multivalency-dependent hemagglutination but not through complement activation
Baudino L, Fossati-Jimack L, Chevalley C, Martinez-Soria E, Shulman MJ and Izui S
Blood, American Society of Hematology vol. 109 (12), 5355-5362.  
22-02-2007

Genetic Dissection of Spontaneous Autoimmunity Driven by 129-Derived Chromosome 1 Loci When Expressed on C57BL/6 Mice
Carlucci F, Cortes-Hernandez J, Fossati-Jimack L, Bygrave AE, Walport MJ, Vyse TJ, Cook HT and Botto M
The Journal of Immunology, The American Association of Immunologists vol. 178 (4), 2352-2360.  
15-02-2007

Contribution of NZB Autoimmunity 2 to Y-Linked Autoimmune Acceleration-Induced Monocytosis in Association with Murine Systemic Lupus
Kikuchi S, Santiago-Raber M-L, Amano H, Amano E, Fossati-Jimack L, Moll T, Kotzin BL and Izui S
The Journal of Immunology, The American Association of Immunologists vol. 176 (5), 3240-3247.  
01-03-2006

The Role of Complement in Cryoglobulin-Induced Immune Complex Glomerulonephritis
Trendelenburg M, Fossati-Jimack L, Cortes-Hernandez J, Turnberg D, Lewis M, Izui S, Cook HT and Botto M
The Journal of Immunology, The American Association of Immunologists vol. 175 (10), 6909-6914.  
15-11-2005

Selective expansion of a monocyte subset expressing the CD11c dendritic cell marker in the Yaa model of systemic lupus erythematosus
Amano H, Amano E, Santiago‐Raber M, Moll T, Martinez‐Soria E, Fossati‐Jimack L, Iwamoto M, Rozzo SJ, Kotzin BL and Izui S
Arthritis & Rheumatism, Wiley vol. 52 (9), 2790-2798.  
01-09-2005

Macrophages from patients with SLE and rheumatoid arthritis have defective adhesion in vitro, while only SLE macrophages have impaired uptake of apoptotic cells
Tas SW, Quartier P, Botto M and Fossati-Jimack L
Annals of The Rheumatic Diseases, Elsevier vol. 65 (2) 
13-07-2005

Identification of 2 major loci linked to autoimmune hemolytic anemia in NZB mice
Kikuchi S, Amano H, Amano E, Fossati-Jimack L, Santiago-Raber M-L, Moll T, Ida A, Kotzin BL and Izui S
Blood, American Society of Hematology vol. 106 (4), 1323-1329.  
28-04-2005

Differential Role of Three Major New Zealand Black-Derived Loci Linked with Yaa-Induced Murine Lupus Nephritis
Kikuchi S, Fossati-Jimack L, Moll T, Amano H, Amano E, Ida A, Ibnou-Zekri N, Laporte C, Santiago-Raber M-L, Rozzo SJ, Kotzin BL and Izui S
The Journal of Immunology, The American Association of Immunologists vol. 174 (2), 1111-1117.  
15-01-2005

Restoration of C1q levels by bone marrow transplantation attenuates autoimmune disease associated with C1q deficiency in mice
Cortes‐Hernandez J, Fossati‐Jimack L, Petry F, Loos M, Izui S, Walport MJ, Cook HT and Botto M
European Journal of Immunology, Wiley vol. 34 (12), 3713-3722.  
26-11-2004

Dissection of BXSB Lupus Phenotype Using Mice Congenic for Chromosome 1 Demonstrates That Separate Intervals Direct Different Aspects of Disease
Haywood MEK, Rogers NJ, Rose SJ, Boyle J, McDermott A, Rankin JM, Thiruudaian V, Lewis MR, Fossati-Jimack L, Izui S, Walport MJ and Morley BJ
The Journal of Immunology, The American Association of Immunologists vol. 173 (7), 4277-4285.  
01-10-2004

Monocytosis and accelerated activation of lymphocytes in C1q‐deficient autoimmune‐prone mice
Trendelenburg M, Manderson AP, Fossati‐Jimack L, Walport MJ and Botto M
Immunology, Wiley vol. 113 (1), 80-88.  
13-08-2004

Multiple loci are linked with anti-red blood cell antibody production in NZB mice−comparison with other phenotypes implies complex modes of action
LEE NJ, RIGBY RJ, GILL H, BOYLE JJ, FOSSATI-JIMACK L, MORLEY BJ and VYSE TJ
Clinical & Experimental Immunology, Oxford University Press (Oup) vol. 138 (1), 39-46.  
23-07-2004

Enforced Bcl‐2 expression in B lymphocytes induces rheumatoid factor and anti‐DNA production, but the Yaa mutation promotes only anti‐DNA production
Kuroki A, Moll T, López‐Hoyos M, Fossati‐Jimack L, Ibnou‐Zekri N, Kikuchi S, Merino J, Merino R and Izui S
European Journal of Immunology, Wiley vol. 34 (4), 1077-1084.  
23-03-2004

Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis.
Norsworthy PJ, Fossati-Jimack L, Cortes-Hernandez J, Taylor PR, Bygrave AE, Thompson RD, Nourshargh S, Walport MJ and Botto M
J Immunol vol. 172 (6), 3406-3414.  
15-03-2004

Differential control of CD22 ligand expression on B and T lymphocytes, and enhanced expression in murine systemic lupus
Lajaunias F, Ida A, Kikuchi S, Fossati‐Jimack L, Martinez‐Soria E, Moll T, Law C and Izui S
Arthritis & Rheumatism, Wiley vol. 48 (6), 1612-1621.  
01-06-2003

Nephrotoxic nephritis is mediated by Fcγ receptors on circulating leukocytes and not intrinsic renal cells
Tarzi RM, Davies KA, Robson MG, Fossati-Jimack L, Saito T, Walport MJ and Cook HT
Kidney International, Elsevier vol. 62 (6), 2087-2096.  
01-12-2002

Murine glomerular mesangial cell uptake of apoptotic cells is inefficient and involves serum-mediated but complement-independent mechanisms
CORTES-HERNANDEZ J, FOSSATI-JIMACK L, CARUGATI A, POTTER PK, WALPORT MJ, COOK HT and BOTTO M
Clinical & Experimental Immunology, Oxford University Press (Oup) vol. 130 (3), 459-466.  
24-11-2002

A Transgenic Mouse Model of Autoimmune Glomerulonephritis and Necrotizing Arteritis Associated with Cryoglobulinemia
Kikuchi S, Pastore Y, Fossati-Jimack L, Kuroki A, Yoshida H, Fulpius T, Araki K, Takahashi S, Lemoine R, Reininger L and Izui S
The Journal of Immunology, The American Association of Immunologists vol. 169 (8), 4644-4650.  
15-10-2002

Level of galactosylation determines cryoglobulin activity of murine IgG3 monoclonal rheumatoid factor
Kuroki A, Kuroda Y, Kikuchi S, Lajaunias F, Fulpius T, Pastore Y, Fossati-Jimack L, Reininger L, Toda T, Nakata M, Kojima N, Mizuochi T and Izui S
Blood, American Society of Hematology vol. 99 (8), 2922-2928.  
15-04-2002

Complement Activation Selectively Potentiates the Pathogenicity of the IgG2b and IgG3 Isotypes of a High Affinity Anti-Erythrocyte Autoantibody
da Silveira SA, Kikuchi S, Fossati-Jimack L, Moll T, Saito T, Verbeek JS, Botto M, Walport MJ, Carroll M and Izui S
Journal of Experimental Medicine, Rockefeller University Press vol. 195 (6), 665-672.  
11-03-2002

C1q Deficiency and Autoimmunity: The Effects of Genetic Background on Disease Expression
Mitchell DA, Pickering MC, Warren J, Fossati-Jimack L, Cortes-Hernandez J, Cook HT, Botto M and Walport MJ
The Journal of Immunology, The American Association of Immunologists vol. 168 (5), 2538-2543.  
01-03-2002

Selective Increase of Autoimmune Epitope Expression on Aged Erythrocytes in Mice: Implications in Anti-erythrocyte Autoimmune Responses
Fossati-Jimack L, da Silveira SA, Moll T, Kina T, Kuypers FA, Oldenborg P-A, Reininger L and Izui S
Journal of Autoimmunity, Elsevier vol. 18 (1), 17-25.  
01-02-2002

Isotype-dependent pathogenicity of autoantibodies: analysis in experimental autoimmune hemolytic anemia
Izui S, Fossati-Jimack L, Azeredo da Silveira S and Moll T
Seminars in Immunopathology, Springer Nature vol. 23 (4), 433-445.  
01-12-2001

Role of galactosylation in the renal pathogenicity of murine immunoglobulin G3 monoclonal cryoglobulins
Mizuochi T, Pastore Y, Shikata K, Kuroki A, Kikuchi S, Fulpius T, Nakata M, Fossati-Jimack L, Reininger L, Matsushita M, Fujita T and Izui S
Blood, American Society of Hematology vol. 97 (11), 3537-3543.  
01-06-2001

Down-Regulated Expression of TWEAK mRNA in Acute and Chronic Inflammatory Pathologies
Chicheportiche Y, Fossati-Jimack L, Moll S, Ibnou-Zekri N and Izui S
Biochemical and Biophysical Research Communications, Elsevier vol. 279 (1), 162-165.  
01-12-2000

Markedly Different Pathogenicity of Four Immunoglobulin G Isotype-Switch Variants of an Antierythrocyte Autoantibody Is Based on Their Capacity to Interact in Vivo with the Low-Affinity Fcγ Receptor III
Fossati-Jimack L, Ioan-Facsinay A, Reininger L, Chicheportiche Y, Watanabe N, Saito T, Hofhuis FMA, Gessner JE, Schiller C, Schmidt RE, Honjo T, Verbeek JS and Izui S
Journal of Experimental Medicine, Rockefeller University Press vol. 191 (8), 1293-1302.  
10-04-2000

The Autoimmune Accelerating Yaa Mutation Does Not Accelerate Murine AIDS
Hügin AW, Fossati-Jimack L and Izui S
Cellular Immunology, Elsevier vol. 200 (2), 76-80.  
01-03-2000

Lessons from BXSB and Related Mouse Models
Izui S, Ibnou-Zekri N, Fossati-jimack L and Iwamoto M
International Reviews of Immunology, Taylor & Francis vol. 19 (4-5), 447-472.  
01-01-2000

High Pathogenic Potential of Low-Affinity Autoantibodies in Experimental Autoimmune Hemolytic Anemia
Fossati-Jimack L, Reininger L, Chicheportiche Y, Clynes R, Ravetch JV, Honjo T and Izui S
Journal of Experimental Medicine, Rockefeller University Press vol. 190 (11), 1689-1696.  
06-12-1999

Role of the major histocompatibility complex class II Ea gene in lupus susceptibility in mice
Ibnou-Zekri N, Iwamoto M, Fossati L, McConahey PJ and Izui S
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 94 (26), 14654-14659.  
23-12-1997

Interleukin-4 Protects against a Genetically Linked Lupus-like Autoimmune Syndrome
Santiago M-L, Fossati L, Jacquet C, Müller W, Izui S and Reininger L
Journal of Experimental Medicine, Rockefeller University Press vol. 185 (1), 65-70.  
01-01-1997

Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice.
Takahashi S, Fossati L, Iwamoto M, Merino R, Motta R, Kobayakawa T and Izui S
Journal of Clinical Investigation, American Society For Clinical Investigation vol. 97 (7), 1597-1604.  
01-04-1996

The Yaa gene‐mediated acceleration of murine lupus: Yaa− T cells from non‐autoimmune mice collaborate with Yaa+ B cells to produce lupus autoantibodies in vivo
Fossati L, Sobel ES, Iwamoto M, Cohen PL, Eisenberg RA and Izui S
European Journal of Immunology, Wiley vol. 25 (12), 3412-3417.  
01-12-1995

Induction of plasminogen activator inhibitor type 1 in murine lupus-like glomerulonephritis
Moll S, Menoud P-A, Fulpius T, Pastore Y, Takahashi S, Fossati L, Vassalli J-D, Sappino A-P, Schifferli JA and Izui S
Kidney International, Elsevier vol. 48 (5), 1459-1468.  
01-11-1995

The Yaa Gene Model of Systemic Lupus Erythematosus
IZUI S, IWAMOTO M, FOSSATI U, MERINO R, TAKAHASHI S and IBNOU‐ZEKRI N
Immunological Reviews, Wiley vol. 144 (1), 137-156.  
01-04-1995

Effect of Long-Term Anti-CD4 or Anti-CD8 Treatment on the Development oflprCD4−CD8−Double Negative T Cells and of the Autoimmune Syndrome in MRL-lpr/lprMice
Merino R, Fossati L, to MI, Takahashi S, Lemoine R, Ibnou-Zekri N, Pugliatti L, Merino J and Izui S
Journal of Autoimmunity, Elsevier vol. 8 (1), 33-45.  
01-02-1995

Selective enhancing effect of the Yaa gene on immune responses against self and foreign antigens
Fossati L, Iwamoto M, Merino R and Izui S
European Journal of Immunology, Wiley vol. 25 (1), 166-173.  
01-01-1995

Mechanisms of genetic control of murine systemic lupus erythematosus
Izui S, Merino R, Iwamoto M and Fossati L
Seminars in Immunopathology, Springer Nature vol. 16 (2-3), 133-152.  
01-12-1994

A CD8+ T-lymphocyte-mediated and CD4+ T-lymphocyte-independent autoimmune diabetes of early onset in transgenic mice
Herrera PL, Harlan DM, Fossati L, Izui S, Huarte J, Orci L, Vassalli JD and Vassalli P
Diabetologia, Springer Nature vol. 37 (12), 1277-1279.  
01-12-1994

Lack of association of Vβ8+ T cells with lupus‐like syndrome in MRL‐lpr/lpr mice
Fossati L, Merino R, Iwamoto M, Lemoine R and Izui S
European Journal of Immunology, Wiley vol. 24 (7), 1717-1720.  
01-07-1994

The Role of the Yaa Gene in Lupus Syndrome
Izui S, Merino R, Fossati L and Iwamoto M
International Reviews of Immunology, Taylor & Francis vol. 11 (3), 211-230.  
01-01-1994

Molecular and Cellular Basis for Pathogenicity of Autoantibodies
IZUI S, BERNEY T, SHIBATA T, FULPIUS T, FOSSATI L and MERINO R
The Tohoku Journal of Experimental Medicine, Tohoku University Medical Press vol. 173 (1) 
01-01-1994

Prevention of systemic lupus erythematosus in autoimmune BXSB mice by a transgene encoding I-E alpha chain.
Merino R, Iwamoto M, Fossati L, Muniesa P, Araki K, Takahashi S, Huarte J, Yamamura K, Vassalli JD and Izui S
Journal of Experimental Medicine, Rockefeller University Press vol. 178 (4), 1189-1197.  
01-10-1993

An MRL/MpJ-lpr/lpr substrain with a limited expansion of lpr double-negative T cells and a reduced autoimmune syndrome
Fossati L, Takahashi S, Merino R, Iwamoto M, Aubry J-P, Nose M, Spach C, Motta R and Izui S
International Immunology, Oxford University Press (Oup) vol. 5 (5), 525-532.  
01-01-1993

The lupus-prone BXSB strain: the Yaa gene model of systemic lupus erythematosus
Merino R, Fossati L and Izui S
Seminars in Immunopathology, Springer Nature vol. 14 (2), 141-157.  
01-10-1992

Effect of Cyclosporin A and Zidovudine on Immune Abnormalities Observed in the Murine Acquired Immunodeficiency Syndrome
Cerny A, Merino R, Fossati L, de Kossodo S, Heusser C, Waldvogel FA, Morse HC and Izui S
The Journal of Infectious Diseases, Oxford University Press (Oup) vol. 166 (2), 285-290.  
01-08-1992

H‐2‐linked control of the Yaa gene‐induced acceleration of lupus‐like autoimmune disease in BXSB mice
Merino R, Fossati L, Lacour M, Lemoine R, Higaki M and Izui S
European Journal of Immunology, Wiley vol. 22 (2), 295-299.  
01-02-1992

Selective autoantibody production by Yaa+ B cells in autoimmune Yaa(+)-Yaa- bone marrow chimeric mice.
Merino R, Fossati L, Lacour M and Izui S
Journal of Experimental Medicine, Rockefeller University Press vol. 174 (5), 1023-1029.  
01-11-1991

Spontaneous production of anti‐mouse red blood cell autoantibodies is independent of the polyclonal activation in NZB mice
Reininger L, Shibata T, Schurmans S, Merino R, Fossati L, Lacour M and Izui S
European Journal of Immunology, Wiley vol. 20 (11), 2405-2410.  
01-11-1990