Dr Liliane Fossati-Jimack

Liliane Fossati-Jimack

Senior Scientific Officer

The William Harvey Research Institute
Queen Mary University of London
+44 (0)20 7882 8194
ORCID

Research

Interests

Synovial tissue explant in vitro culture

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2025

Spatial mapping of rheumatoid arthritis synovial niches reveals a LYVE1+ macrophage network associated with response to therapy
De Lima J, Boutet M-A, Bortolotti O, Chépeaux L-A, Glasson Y, Dumé A-S, Lau R, Humbert P et al.
Annals of The Rheumatic Diseases, Elsevier 
01-08-2025
Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis
Lewis MJ, Çubuk C, Surace AEA, Sciacca E, Lau R, Goldmann K, Giorli G, Fossati-Jimack L et al.
Nature Communications, Springer Nature vol. 16 (1) 
02-07-2025

2024

POS0351 A POST-HOC ANALYSIS OF THE BIOPSY-DRIVEN, MULTICENTRE, RANDOMISED R4RA CLINICAL TRIAL REVEALS AN INNATE IMMUNE SIGNATURE IN MULTI-DRUG RESISTANT RHEUMATOID ARTHRITIS PATIENTS WITH A LYMPHO-MYELOID PATHOTYPE
Iaquinta FS, Sciacca E, Abatecola F, Fossati-Jimack L, Pitzalis C, Rivellese F, Group OBORC
EULAR 2024. 
10-06-2024
OP0218 SYNOVIAL PHOSPHOPROTEOME ANALYSIS OF LATE-STAGE RHEUMATOID ARTHRITIS PATIENTS (R4RA TRIAL) IDENTIFIES SIGNALLING PATHWAYS ASSOCIATED WITH PATHOTYPE AND RESPONSE TO RITUXIMAB AND TOCILIZUMAB
Lau R, Cubuk C, Rajeeve V, Cutillas P, Hands R, Fossati-Jimack L, Surace A, Lewis M et al.
EULAR 2024. 
01-06-2024
OP0224 INTEGRATION OF DNA METHYLATION INTO MULTI-OMIC ANALYSIS OF SYNOVIAL BIOPSIES FROM THE STRAP RANDOMIZED CLINICAL TRIAL IDENTIFIES PREDICTORS OF RESPONSE TO ANTI-TNF THERAPY IN RHEUMATOID ARTHRITIS
Wang S, Nair N, Cubuk C, Yap CF, Lau R, Giorli G, Fossati-Jimack L, Plant D et al.
EULAR 2024. 
01-06-2024
OP0242 SYNOVIAL TISSUE AND BLOOD DEEP B/T CELL PHENOTYPING EXPLAINS RESPONSE MECHANISMS TO RITUXIMAB IN RHEUMATOID ARTHRITIS IN R4RA
Surace A, Overend L, Sciacca E, Fossati-Jimack L, Jaworska E, Pontarini E, Bashford-Rogers RJM, Pitzalis C et al.
EULAR 2024. 
01-06-2024
Serum and Tissue Biomarkers Associated With Composite of Relevant Endpoints for Sjögren Syndrome (CRESS) and Sjögren Tool for Assessing Response (STAR) to B Cell–Targeted Therapy in the Trial of Anti–B Cell Therapy in Patients With Primary Sjögren Syndrome (TRACTISS)
Arthritis & Rheumatology, Wiley vol. 76 (5), 763-776.  
15-02-2024
Phosphoproteomic profiling of early rheumatoid arthritis synovium reveals active signalling pathways and differentiates inflammatory pathotypes
Çubuk C, Lau R, Cutillas P, Rajeeve V, John CR, Surace AEA, Hands R, Fossati-Jimack L et al.
Arthritis Research & Therapy, Springer Nature vol. 26 (1) 
01-01-2024

2023

Comparative analysis of late-stage rheumatoid arthritis and osteoarthritis reveals shared histopathological features
Boutet M-A, Nerviani A, Fossati-Jimack L, Hands-Greenwood R, Ahmed M, Rivellese F, Pitzalis C
Osteoarthritis and Cartilage, Elsevier vol. 32 (2), 166-176.  
19-11-2023
AB0067 MODE OF ACTION AND TARGET INVESTIGATION OF THE NEW ANTI-RHEUMATIC DRUG RABEXIMOD.
Ghirardi GM, Nerviani A, Fossati-Jimack L, Pontarini E, Italiani P, Pratesi F, Abdelmoaty S, Högerkorp C et al.
Annals of The Rheumatic Diseases, Elsevier vol. 82, 1212-1213.  
01-06-2023

2022

Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis
Shikh MEME, Sayed RE, Aly NAR, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis MJ et al.
Frontiers in Medicine, Frontiers vol. 9 
16-11-2022
Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming
Cooles FAH, Tarn J, Lendrem DW, Naamane N, Lin CM, Millar B, Maney NJ, Anderson AE et al.
Annals of The Rheumatic Diseases, Elsevier vol. 81 (9), 1214-1223.  
11-08-2022
Rituximab versus tocilizumab and B-cell status in TNF-alpha inadequate-responder rheumatoid arthritis patients:the R4-RA RCT
Humby F, Durez P, Buch MH, Lewis MJ, Bombardieri M, John C, Rizvi H, Warren L et al.
Efficacy and Mechanism Evaluation, National Institute For Health and Care Research vol. 9 (7), 1-58.  
01-08-2022
POS0431 PDGF-BB, TNF-α, AND LT-β REGULATE FOLLICULAR DENDRITIC CELL DEVELOPMENT IN THE RHEUMATOID SYNOVIUM
Elshikh M, Sayed RE, Aly N, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis M et al.
Annals of The Rheumatic Diseases, Elsevier vol. 81 
01-06-2022
OP0077 SYNOVIAL RNA-SEQ ANALYSIS OF THE R4RA TRIAL IDENTIFIES SIGNATURES OF TREATMENT RESISTANCE AND REFRACTORY STATE IN RHEUMATOID ARTHRITIS
Surace A, Sciacca E, Goldmann K, Rivellese F, Cubuk C, Giorli G, Fossati-Jimack L, Ahmed M et al.
Annals of The Rheumatic Diseases, Elsevier vol. 81, 52-53.  
01-06-2022
OP0085 CELL LINEAGE-SPECIFIC TRANSCRIPT DECONVOLUTION OF SYNOVIAL BIOPSIES FROM THE R4RA TRIAL IDENTIFIES CELL POPULATIONS ASSOCIATED WITH RESPONSE TO RITUXIMAB AND TOCILIZUMAB
Rivellese F, Cubuk C, Surace A, Goldmann K, Sciacca E, Giorli G, Nerviani A, Fossati-Jimack L et al.
Annals of The Rheumatic Diseases, Elsevier vol. 81, 56-57.  
01-06-2022
POS0145 CLINICAL RESPONSE TO RITUXIMAB IS ASSOCIATED WITH PREVENTION OF B-CELL DRIVEN SALIVARY GLAND INFLAMMATION AND EPITHELIAL RESTORATION AS REVEALED BY MOLECULAR PATHOLOGY: RESULTS FROM THE TRACTISS TRIAL IN PRIMARY SJOGREN'S SYNDROME
Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Murray-Brown W, Rivellese F, Lucchesi D, Goldmann K et al.
 
01-06-2022
Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial
Rivellese F, Surace AEA, Goldmann K, Sciacca E, Çubuk C, Giorli G, John CR, Nerviani A et al.
Nature Medicine, Springer Nature vol. 28 (6), 1256-1268.  
19-05-2022
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients
Isaacs JD, Brockbank S, Pedersen AW, Hilkens C, Anderson A, Stocks P, Lendrem D, Tarn J et al.
Scientific Data, Springer Nature vol. 9 (1) 
09-05-2022

2021

OP0136 RITUXIMAB PREVENTS THE PROGRESSION OF B-CELL DRIVEN INFLAMMATORY INFILTRATE IN THE MINOR SALIVARY GLANDS OF PRIMARY SJOGREN’S SYNDROME BY DOWNREGULATING IMMUNOLOGICAL PATHWAYS KEY IN ECTOPIC GERMINAL CENTRE ORGANIZATION: RESULTS FROM THE TRACTISS TRIAL
Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Goldmann K, Fossati-Jimack L et al.
Annals of The Rheumatic Diseases vol. 80 (Suppl 1), 79-80.  
17-09-2021
NKp30 Receptor Upregulation in Salivary Glands of Sjögren’s Syndrome Characterizes Ectopic Lymphoid Structures and Is Restricted by Rituximab Treatment
Frontiers in Immunology, Frontiers vol. 12 
14-09-2021
OP0011 INTEGRATION OF FLOW AND DIGITAL CYTOMETRY IN EARLY TREATMENT-NAÏVE RHEUMATOID ARTHRITIS IDENTIFIES DISTINCT IMMUNOPHENOTYPES IN PERIPHERAL BLOOD AND DISEASE TISSUE
Rivellese F, Pontarini E, Fossati-Jimack L, Moura RA, Romão VC, Fonseca JE, Nerviani A, Cubuk C et al.
Annals of The Rheumatic Diseases, Elsevier vol. 80 
01-06-2021
Novel Bispecific Antibody for Synovial-Specific Target Delivery of Anti-TNF Therapy in Rheumatoid Arthritis
Ferrari M, Onuoha SC, Fossati-Jimack L, Nerviani A, Alves PL, Pagani S, Deantonio C, Colombo F et al.
Frontiers in Immunology vol. 12 
19-02-2021
Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial
Humby F, Durez P, Buch MH, Lewis MJ, Rizvi H, Rivellese F, Nerviani A, Giorli G et al.
The Lancet, Elsevier vol. 397 (10271), 305-317.  
01-01-2021

2020

C3 Drives Inflammatory Skin Carcinogenesis Independently of C5
Jackson WD, Gulino A, Fossati-Jimack L, Seoane RC, Tian K, Best K, Köhl J, Belmonte B et al.
Journal of Investigative Dermatology, Elsevier vol. 141 (Immunobiology 209 7 ), 404-414.e6.  
16-07-2020
OP0217 INVOLVEMENT OF LARGE JOINTS AT DISEASE PRESENTATION IS ASSOCIATED WITH DIVERSE HISTOPATHOLOGICAL FEATURES AND CLINICAL OUTCOMES IN EARLY RHEUMATOID ARTHRITIS
Rivellese F, Humby F, Ribera GL, Nerviani A, Sciacca E, Giorli G, Hands R, Fossati-Jimack L et al.
 
01-06-2020
P233 B cell-rich synovitis in early and established rheumatoid arthritis
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al.
Rheumatology vol. 59 (Supplement_2) 
01-04-2020
B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure.
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al.
Arthritis and Rheumatology, Wiley 
17-03-2020

2019

Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis
El Shikh MEM, El Sayed R, Nerviani A, Goldmann K, John CR, Hands R, Fossati-Jimack L, Lewis MJ et al.
Journal of Autoimmunity, Elsevier Bv 
01-07-2019
THU0058 B CELL SYNOVITIS AND CLINICAL PHENOTYPES IN RHEUMATOID ARTHRITIS AT DIFFERENT DISEASE STAGES
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Ribera GL, Nerviani A et al.
Annual European Congress of Rheumatology, EULAR 2019 Madrid 12 Jun 2019 - 15 Jun 2019. 
13-06-2019
OP0279 A UNIQUE IL-21 SIGNATURE CHARACTERIZES LESIONAL AND CIRCULATING T-FOLLICULAR HELPER CELLS IN SJÖGREN'S SYNDROME PATIENTS WITH ECTOPIC GERMINAL CENTRES AND MALT LYMPHOMA
 
01-06-2019

2018

NK cell recruitment in salivary glands provides early viral control but is dispensable for tertiary lymphoid structure formation
Pontarini E, Lucchesi D, Fossati-Jimack L, Coleby R, Tentorio P, Croia C, Bombardieri M, Mavilio D
Journal of Leukocyte Biology, Oxford University Press (Oup) vol. 105 (3), 589-602.  
21-12-2018
The RA-MAP Consortium: a working model for academia-industry collaboration.
Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA et al.
Nat Rev Rheumatol vol. 14 (1), 53-60.  
07-12-2018
Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production
Rivellese F, Mauro D, Nerviani A, Pagani S, Fossati-Jimack L, Messemaker T, Kurreeman FAS, Toes REM et al.
Annals of The Rheumatic Diseases, Elsevier vol. 77 (12), 1773-1781.  
20-08-2018
O001 Lymphoid tissue macrophages express peptidylarginine deiminase 2 and 4: new implications in citrullination and anti-citrulline antibodies production in autoimmune arthritis
Shikh ME, Sayed RE, Fossati-Jimack L, Pitzalis C
 
01-03-2018

2016

Complement receptor 3 mediates renal protection in experimental C3 glomerulopathy
Barbour TD, Ling GS, Ruseva MM, Fossati-Jimack L, Cook HT, Botto M, Pickering MC
Kidney International, Elsevier vol. 89 (4), 823-832.  
03-02-2016

2015

Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1low Monocytes
Saja MF, Baudino L, Jackson WD, Cook HT, Malik TH, Fossati-Jimack L, Ruseva M, Pickering MC et al.
Cell Reports, Elsevier vol. 12 (11), 1802-1815.  
01-09-2015

2014

Intranasal peptide‐induced tolerance and linked suppression: consequences of complement deficiency
Fossati-Jimack L, Ling GS, Baudino L, Szajna M, Manivannan K, Zhao JC, Midgley R, Chai J-G et al.
Immunology, Wiley vol. 144 (1), 149-157.  
08-12-2014
Mechanisms of complement activation by dextran-coated superparamagnetic iron oxide (SPIO) nanoworms in mouse versus human serum
Banda NK, Mehta G, Chao Y, Wang G, Inturi S, Fossati-Jimack L, Botto M, Wu L et al.
Particle and Fibre Toxicology, Springer Nature vol. 11 (1) 
26-11-2014
IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut
Sattler S, Ling G-S, Xu D, Hussaarts L, Romaine A, Zhao H, Fossati-Jimack L, Malik T et al.
Journal of Autoimmunity, Elsevier vol. 50 (100), 107-122.  
01-02-2014
C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens
Baudino L, Sardini A, Ruseva MM, Fossati-Jimack L, Cook HT, Scott D, Simpson E, Botto M
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 111 (4), 1503-1508.  
13-01-2014
Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages
Ling GS, Bennett J, Woollard KJ, Szajna M, Fossati-Jimack L, Taylor PR, Scott D, Franzoso G et al.
Nature Communications, Springer Nature vol. 5 (1) 
01-01-2014

2013

Phagocytosis Is the Main CR3-Mediated Function Affected by the Lupus-Associated Variant of CD11b in Human Myeloid Cells
Fossati-Jimack L, Ling GS, Cortini A, Szajna M, Malik TH, McDonald JU, Pickering MC, Cook HT et al.
Plos One, Public Library of Science (Plos) vol. 8 (2) 
01-01-2013

2012

Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia
Lewis MJ, Malik TH, Fossati‐Jimack L, Carassiti D, Cook HT, Haskard DO, Botto M
Arthritis & Rheumatism, Wiley vol. 64 (8), 2707-2718.  
27-07-2012
An essential protective role of IL-10-producing regulatory B cells against IL-33-mediated mucosal inflammation
Huang FP, Sattler S, Ling GS, Xu D, Hussaart L, Romaine A, Zhao HZ, Cook HT et al.
 
01-01-2012

2011

Mice with defective Fas ligand are protected from crescentic glomerulonephritis
Tarzi RM, Sharp PEH, McDaid JP, Fossati-Jimack L, Herbert PE, Pusey CD, Cook HT, Warrens AN
Kidney International, Elsevier vol. 81 (2), 170-178.  
14-09-2011
A novel mouse model of systemic lupus erythematosus (SLE) and atherosclerosis: Distinct roles of complement in the kidney and atherosclerotic plaques
Botto, Lewis, Malik, Fossati-Jimack, Cook
 
01-08-2011
In vivo functional analysis and genetic modification of in vitro‐derived mouse neutrophils
McDonald JU, Cortini A, Rosas M, Fossati‐Jimack L, Ling GS, Lewis KJ, Dewitt S, Liddiard K et al.
The Faseb Journal, Wiley vol. 25 (6), 1972-1982.  
02-03-2011

2010

Identification and Characterization of a Lupus Suppressor 129 Locus on Chromosome 3
Carlucci F, Fossati-Jimack L, Dumitriu IE, Heidari Y, Walport MJ, Szajna M, Baruah P
The Journal of Immunology, Oxford University Press (Oup) vol. 184 (11), 6256-6265.  
01-06-2010
Evidence that Yaa-induced loss of marginal zone B cells is a result of dendritic cell-mediated enhanced activation
Santiago-Raber M-L, Amano H, Fossati-Jimack L, Swee LK
Journal of Autoimmunity, Elsevier vol. 34 (4), 349-355.  
10-02-2010

2009

COMPLEMENT DYSREGULATION LINKS ACCELERATED ATHEROSCLEROSIS AND GLOMERULONEPHRITIS IN SLE
Lewis MJ, Malik TH, Fossati-Jimack LM, Carassiti D, Cook TH, Haskard DO, Botto M
 
01-01-2009

2008

A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice
Heidari Y, Fossati-Jimack L, Carlucci F, Cook HT
Genes & Immunity, Springer Nature vol. 10 (1), 47-55.  
09-10-2008
Dissection of Genetic Mechanisms Governing the Expression of Serum Retroviral gp70 Implicated in Murine Lupus Nephritis
Baudino L, Yoshinobu K, Morito N, Kikuchi S, Fossati-Jimack L, Morley BJ, Vyse TJ, Hirose S et al.
The Journal of Immunology, Oxford University Press (Oup) vol. 181 (4), 2846-2854.  
15-08-2008
CD4+ T cells play a major role for IgM and IgG anti-DNA production in mice infected with Plasmodium yoelii
Fossati L, Izui S
Clinical & Experimental Immunology, Oxford University Press (Oup) vol. 79 (2), 291-296.  
28-06-2008
Regulation of B cell tolerance by 129‐derived chromosome 1 loci in C57BL/6 mice
Fossati‐Jimack L, Cortes‐Hernandez J, Norsworthy PJ, Cook HT, Walport MJ, Botto M
Arthritis & Rheumatism, Wiley vol. 58 (7), 2131-2141.  
24-06-2008
Lupus phenotype accelerates atherosclerosis in a novel mouse model of SLE
Lewis MJ, Malik TH, Fossati-Jimack LM, Carassiti D, Cook TH, Haskard DO, Botto M
 
01-01-2008

2007

C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice
Fossati-Jimack L, Cortes-Hernandez J, Norsworthy PJ, Walport MJ, Cook HT, Botto M
Molecular Immunology, Elsevier vol. 45 (3), 787-795.  
01-08-2007
IgM and IgA anti-erythrocyte autoantibodies induce anemia in a mouse model through multivalency-dependent hemagglutination but not through complement activation
Baudino L, Fossati-Jimack L, Chevalley C, Martinez-Soria E, Shulman MJ, Izui S
Blood, American Society of Hematology vol. 109 (12), 5355-5362.  
22-02-2007
Genetic Dissection of Spontaneous Autoimmunity Driven by 129-Derived Chromosome 1 Loci When Expressed on C57BL/6 Mice
Carlucci F, Cortes-Hernandez J, Fossati-Jimack L, Bygrave AE, Walport MJ, Vyse TJ
The Journal of Immunology, Oxford University Press (Oup) vol. 178 (4), 2352-2360.  
15-02-2007
C1q can alter the levels of IgM autoantibody production in anti-DNA transgenic models
Fossati-Jimack L, Cortes-Hernandez J, Norsworthy P, Cook HT
 
01-01-2007

2006

Contribution of NZB Autoimmunity 2 to Y-Linked Autoimmune Acceleration-Induced Monocytosis in Association with Murine Systemic Lupus
Kikuchi S, Santiago-Raber M-L, Amano H, Amano E, Fossati-Jimack L, Moll T, Kotzin BL, Izui S
The Journal of Immunology, Oxford University Press (Oup) vol. 176 (5), 3240-3247.  
01-03-2006
Genetic contribution of 129 chromosome 1 intervals to autoimmunity in C57BL/6 mice
Carlucci F, Cortes-Hernandez J, Fossati-Jimack LM, Bygrave AE, Cook TH
 
01-01-2006

2005

The Role of Complement in Cryoglobulin-Induced Immune Complex Glomerulonephritis
Trendelenburg M, Fossati-Jimack L, Cortes-Hernandez J, Turnberg D, Lewis M, Izui S, Cook HT, Botto M
The Journal of Immunology, Oxford University Press (Oup) vol. 175 (10), 6909-6914.  
15-11-2005
Selective expansion of a monocyte subset expressing the CD11c dendritic cell marker in the Yaa model of systemic lupus erythematosus
Amano H, Amano E, Santiago‐Raber M, Moll T, Martinez‐Soria E, Fossati‐Jimack L, Iwamoto M, Rozzo SJ et al.
Arthritis & Rheumatism, Wiley vol. 52 (9), 2790-2798.  
01-09-2005
Macrophages from patients with SLE and rheumatoid arthritis have defective adhesion in vitro, while only SLE macrophages have impaired uptake of apoptotic cells
Tas SW, Quartier P, Botto M
Annals of The Rheumatic Diseases, Elsevier vol. 65 (2), 216-221.  
13-07-2005
Identification of 2 major loci linked to autoimmune hemolytic anemia in NZB mice
Kikuchi S, Amano H, Amano E, Fossati-Jimack L, Santiago-Raber M-L, Moll T, Ida A, Kotzin BL et al.
Blood, American Society of Hematology vol. 106 (4), 1323-1329.  
28-04-2005
Differential Role of Three Major New Zealand Black-Derived Loci Linked with Yaa-Induced Murine Lupus Nephritis
Kikuchi S, Fossati-Jimack L, Moll T, Amano H, Amano E, Ida A, Ibnou-Zekri N, Laporte C et al.
The Journal of Immunology, Oxford University Press (Oup) vol. 174 (2), 1111-1117.  
15-01-2005

2004

Restoration of C1q levels by bone marrow transplantation attenuates autoimmune disease associated with C1q deficiency in mice
Cortes‐Hernandez J, Fossati‐Jimack L, Petry F, Izui S, Walport MJ
European Journal of Immunology, Wiley vol. 34 (12), 3713-3722.  
26-11-2004
Dissection of BXSB Lupus Phenotype Using Mice Congenic for Chromosome 1 Demonstrates That Separate Intervals Direct Different Aspects of Disease
Haywood MEK, Rogers NJ, Rose SJ, Boyle J, McDermott A, Rankin JM, Thiruudaian V, Fossati-Jimack L
The Journal of Immunology, Oxford University Press (Oup) vol. 173 (7), 4277-4285.  
01-10-2004
Monocytosis and accelerated activation of lymphocytes in C1q‐deficient autoimmune‐prone mice
Trendelenburg M, Manderson AP, Fossati‐Jimack L, Walport MJ
Immunology, Wiley vol. 113 (1), 80-88.  
13-08-2004
Multiple loci are linked with anti-red blood cell antibody production in NZB mice−comparison with other phenotypes implies complex modes of action
LEE NJ, RIGBY RJ, GILL H, BOYLE JJ, VYSE TJ
Clinical & Experimental Immunology, Oxford University Press (Oup) vol. 138 (1), 39-46.  
23-07-2004
Enforced Bcl‐2 expression in B lymphocytes induces rheumatoid factor and anti‐DNA production, but the Yaa mutation promotes only anti‐DNA production
Kuroki A, Moll T, López‐Hoyos M, Fossati‐Jimack L, Ibnou‐Zekri N, Merino J
European Journal of Immunology, Wiley vol. 34 (4), 1077-1084.  
23-03-2004
Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis.
Norsworthy PJ, Fossati-Jimack L, Cortes-Hernandez J, Taylor PR, Bygrave AE, Thompson RD, Nourshargh S, Walport MJ et al.
J Immunol vol. 172 (6), 3406-3414.  
15-03-2004

2003

Differential control of CD22 ligand expression on B and T lymphocytes, and enhanced expression in murine systemic lupus
Lajaunias F, Ida A, Kikuchi S, Fossati‐Jimack L, Martinez‐Soria E, Moll T, Law C, Izui S
Arthritis & Rheumatism, Wiley vol. 48 (6), 1612-1621.  
01-06-2003

2002

Nephrotoxic nephritis is mediated by Fcγ receptors on circulating leukocytes and not intrinsic renal cells
Tarzi RM, Davies KA, Robson MG, Fossati-Jimack L, Saito T, Walport MJ, Cook HT
Kidney International, Elsevier vol. 62 (6), 2087-2096.  
01-12-2002
Murine glomerular mesangial cell uptake of apoptotic cells is inefficient and involves serum-mediated but complement-independent mechanisms
CORTES-HERNANDEZ J, FOSSATI-JIMACK L, CARUGATI A, COOK HT
Clinical & Experimental Immunology, Oxford University Press (Oup) vol. 130 (3), 459-466.  
24-11-2002
A Transgenic Mouse Model of Autoimmune Glomerulonephritis and Necrotizing Arteritis Associated with Cryoglobulinemia
Kikuchi S, Pastore Y, Fossati-Jimack L, Kuroki A, Yoshida H, Fulpius T, Araki K, Takahashi S
The Journal of Immunology, Oxford University Press (Oup) vol. 169 (8), 4644-4650.  
15-10-2002
Level of galactosylation determines cryoglobulin activity of murine IgG3 monoclonal rheumatoid factor
Kuroki A, Kuroda Y, Kikuchi S, Lajaunias F, Fulpius T, Fossati-Jimack L, Reininger L, Nakata M et al.
Blood, American Society of Hematology vol. 99 (8), 2922-2928.  
15-04-2002
Complement Activation Selectively Potentiates the Pathogenicity of the IgG2b and IgG3 Isotypes of a High Affinity Anti-Erythrocyte Autoantibody
da Silveira SA, Kikuchi S, Fossati-Jimack L, Moll T, Saito T, Verbeek JS, Botto M, Walport MJ et al.
Journal of Experimental Medicine, Rockefeller University Press vol. 195 (6), 665-672.  
11-03-2002
C1q Deficiency and Autoimmunity: The Effects of Genetic Background on Disease Expression
Mitchell DA, Pickering MC, Warren J, Fossati-Jimack L, Cortes-Hernandez J, Botto M
The Journal of Immunology, Oxford University Press (Oup) vol. 168 (5), 2538-2543.  
01-03-2002
Selective Increase of Autoimmune Epitope Expression on Aged Erythrocytes in Mice: Implications in Anti-erythrocyte Autoimmune Responses
Fossati-Jimack L, da Silveira SA, Moll T, Kina T, Kuypers FA, Reininger L
Journal of Autoimmunity, Elsevier vol. 18 (1), 17-25.  
01-02-2002

2001

Isotype-dependent pathogenicity of autoantibodies: analysis in experimental autoimmune hemolytic anemia
Izui S, Fossati-Jimack L, Moll T
Seminars in Immunopathology, Springer Nature vol. 23 (4), 433-445.  
01-12-2001
Role of galactosylation in the renal pathogenicity of murine immunoglobulin G3 monoclonal cryoglobulins
Mizuochi T, Pastore Y, Shikata K, Kuroki A, Kikuchi S, Fulpius T, Fossati-Jimack L, Matsushita M et al.
Blood, American Society of Hematology vol. 97 (11), 3537-3543.  
01-06-2001

2000

Down-Regulated Expression of TWEAK mRNA in Acute and Chronic Inflammatory Pathologies
Chicheportiche Y, Fossati-Jimack L, Moll S, Ibnou-Zekri N, Izui S
Biochemical and Biophysical Research Communications, Elsevier vol. 279 (1), 162-165.  
01-12-2000
Markedly Different Pathogenicity of Four Immunoglobulin G Isotype-Switch Variants of an Antierythrocyte Autoantibody Is Based on Their Capacity to Interact in Vivo with the Low-Affinity Fcγ Receptor III
Fossati-Jimack L, Ioan-Facsinay A, Reininger L, Chicheportiche Y, Watanabe N, Saito T, Gessner JE, Schiller C et al.
Journal of Experimental Medicine, Rockefeller University Press vol. 191 (8), 1293-1302.  
10-04-2000
The Autoimmune Accelerating Yaa Mutation Does Not Accelerate Murine AIDS
Hügin AW, Izui S
Cellular Immunology, Elsevier vol. 200 (2), 76-80.  
01-03-2000
Lessons from BXSB and Related Mouse Models
Izui S, Ibnou-Zekri N, Fossati-jimack L
International Reviews of Immunology, Taylor & Francis vol. 19 (4-5), 447-472.  
01-01-2000

1999

High Pathogenic Potential of Low-Affinity Autoantibodies in Experimental Autoimmune Hemolytic Anemia
Fossati-Jimack L, Reininger L, Chicheportiche Y, Ravetch JV
Journal of Experimental Medicine, Rockefeller University Press vol. 190 (11), 1689-1696.  
06-12-1999

1997

Role of the major histocompatibility complex class II Ea gene in lupus susceptibility in mice
Ibnou-Zekri N, Iwamoto M, Fossati L
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 94 (26), 14654-14659.  
23-12-1997
Interleukin-4 Protects against a Genetically Linked Lupus-like Autoimmune Syndrome
Santiago M-L, Fossati L, Jacquet C, Izui S, Reininger L
Journal of Experimental Medicine, Rockefeller University Press vol. 185 (1), 65-70.  
01-01-1997

1996

Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice.
Takahashi S, Fossati L, Iwamoto M, Merino R, Motta R, Kobayakawa T, Izui S
Journal of Clinical Investigation, American Society For Clinical Investigation vol. 97 (7), 1597-1604.  
01-04-1996

1995

The Yaa gene‐mediated acceleration of murine lupus: Yaa− T cells from non‐autoimmune mice collaborate with Yaa+ B cells to produce lupus autoantibodies in vivo
Fossati L, Sobel ES, Iwamoto M, Cohen PL, Eisenberg RA, Izui S
European Journal of Immunology, Wiley vol. 25 (12), 3412-3417.  
01-12-1995
Induction of plasminogen activator inhibitor type 1 in murine lupus-like glomerulonephritis
Moll S, Menoud P-A, Fulpius T, Pastore Y, Fossati L, Vassalli J-D
Kidney International, Elsevier vol. 48 (5), 1459-1468.  
01-11-1995
The Yaa Gene Model of Systemic Lupus Erythematosus
IZUI S, IWAMOTO M, FOSSATI U, TAKAHASHI S
Immunological Reviews, Wiley vol. 144 (1), 137-156.  
01-04-1995
Effect of Long-Term Anti-CD4 or Anti-CD8 Treatment on the Development oflprCD4−CD8−Double Negative T Cells and of the Autoimmune Syndrome in MRL-lpr/lprMice
Merino R, Fossati L, to MI, Takahashi S, Lemoine R, Ibnou-Zekri N, Pugliatti L, Merino J et al.
Journal of Autoimmunity, Elsevier vol. 8 (1), 33-45.  
01-02-1995
Selective enhancing effect of the Yaa gene on immune responses against self and foreign antigens
Fossati L, Iwamoto M, Izui S
European Journal of Immunology, Wiley vol. 25 (1), 166-173.  
01-01-1995

1994

Mechanisms of genetic control of murine systemic lupus erythematosus
Izui S, Merino R, Iwamoto M
Seminars in Immunopathology, Springer Nature vol. 16 (2-3), 133-152.  
01-12-1994
A CD8+ T-lymphocyte-mediated and CD4+ T-lymphocyte-independent autoimmune diabetes of early onset in transgenic mice
Herrera PL, Harlan DM, Fossati L, Orci L, Vassalli JD
Diabetologia, Springer Nature vol. 37 (12), 1277-1279.  
01-12-1994
Lack of association of Vβ8+ T cells with lupus‐like syndrome in MRL‐lpr/lpr mice
Fossati L, Merino R, Iwamoto M, Lemoine R
European Journal of Immunology, Wiley vol. 24 (7), 1717-1720.  
01-07-1994
The Role of the Yaa Gene in Lupus Syndrome
Izui S, Merino R, Fossati L
International Reviews of Immunology, Taylor & Francis vol. 11 (3), 211-230.  
01-01-1994
Molecular and Cellular Basis for Pathogenicity of Autoantibodies
IZUI S, BERNEY T, SHIBATA T, MERINO R
The Tohoku Journal of Experimental Medicine, Tohoku University Medical Press vol. 173 (1) 
01-01-1994

1993

Prevention of systemic lupus erythematosus in autoimmune BXSB mice by a transgene encoding I-E alpha chain.
Merino R, Iwamoto M, Fossati L, Muniesa P, Araki K, Takahashi S, Huarte J, Yamamura K et al.
Journal of Experimental Medicine, Rockefeller University Press vol. 178 (4), 1189-1197.  
01-10-1993
An MRL/MpJ-lpr/lpr substrain with a limited expansion of lpr double-negative T cells and a reduced autoimmune syndrome
Fossati L, Takahashi S, Merino R, Iwamoto M, Aubry J-P, Nose M, Spach C
International Immunology, Oxford University Press (Oup) vol. 5 (5), 525-532.  
01-01-1993

1992

The lupus-prone BXSB strain: the Yaa gene model of systemic lupus erythematosus
Merino R, Fossati L
Seminars in Immunopathology, Springer Nature vol. 14 (2), 141-157.  
01-10-1992
Effect of Cyclosporin A and Zidovudine on Immune Abnormalities Observed in the Murine Acquired Immunodeficiency Syndrome
Cerny A, Merino R, Fossati L, de Kossodo S, Heusser C, Waldvogel FA, Morse HC, Izui S
The Journal of Infectious Diseases, Oxford University Press (Oup) vol. 166 (2), 285-290.  
01-08-1992
H‐2‐linked control of the Yaa gene‐induced acceleration of lupus‐like autoimmune disease in BXSB mice
Merino R, Fossati L, Lacour M, Lemoine R
European Journal of Immunology, Wiley vol. 22 (2), 295-299.  
01-02-1992

1991

Selective autoantibody production by Yaa+ B cells in autoimmune Yaa(+)-Yaa- bone marrow chimeric mice.
Merino R, Fossati L, Lacour M
Journal of Experimental Medicine, Rockefeller University Press vol. 174 (5), 1023-1029.  
01-11-1991

1990

Spontaneous production of anti‐mouse red blood cell autoantibodies is independent of the polyclonal activation in NZB mice
Reininger L, Shibata T, Schurmans S, Merino R, Fossati L
European Journal of Immunology, Wiley vol. 20 (11), 2405-2410.  
01-11-1990

Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren’s syndrome with ectopic germinal centres and MALT lymphoma.
Annals of The Rheumatic Diseases, Bmj Publishing Group 
Spatial mapping of rheumatoid arthritis synovial niches reveals specific macrophage networks associated with response to therapy
De Lima J, Boutet M-A, Bortolotti O, Chépeaux L-A, Glasson Y, Dumé A-S, Le Pluart A, Nerviani A et al.
In Biorxiv 
Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and impacts clinical response
Corsiero E, Bombardieri MICHELE
The Journal of Clinical Investigation, American Society For Clinical Investigation 
Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues
Rolas L, Stein M, Barkaway A, Reglero N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L et al.
Embo Reports, Springer 

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconCollaboration Agreement - Data - Material Access - BMS R4RA /PEAC /STRAP COMBINED
Costantino Pitzalis and Liliane Fossati-Jimack
£870,000 Bristol-Myers Squibb Pharmaceuticals Ltd
01-12-2023 - 30-11-2029