Prof Leonardo Guasti
Professor of Experimental Endocrinology
FMD/WHRI/Centre for Endocrinology
Queen Mary University of London
Queen Mary University of London
Research
stem cells, adrenal cortex, organoids, replacement cell therapy
Interests
Expertise in reprogramming strategies to derive adrenocortical cells. Generation of normal and cancerous adrenal organoids from mice and humans. Funded by MRC (adrenal organoids) and BBSRC (contribution of adrenal stem/progenitor cells to the physiological remodelling of the gland).Publications
Publications of specific relevance to Predictive in vitro Models
2024
d'Aniello F, Mariniello K, Al Sayed Y, Bhavsar K, Read JE, Guasti L and Howard SR (2024). The Role of DLK1 Deficiency in Central Precocious Puberty and Association with Metabolic Dysregulation. Karger Publishers Hormone Research in Paediatrics 1-11.
Gualtieri A, Gomez-Corral L, Nicholson J, Tan R, Guasti L and Gaston-Massuet C (2024). 12408 Efnb2 Controls Pituitary Gland Development By Regulating Proliferation Of Pituitary Stem Cells. The Endocrine Society Journal of the Endocrine Society vol. 8, (Supplement_1)
Champsi A, Mobley AR, Subramanian A, Nirantharakumar K, Wang X, Shukla D, Bunting KV, Molgaard I, Dwight J, Arroyo RC, Crijns HJGM, Guasti L, Lettino M, Lumbers RT, Maesen B, Rienstra M, Svennberg E, Țica O, Traykov V, Tzeis S, van Gelder I and Kotecha D (2024). Gender and contemporary risk of adverse events in atrial fibrillation. Oxford University Press (OUP) European Heart Journal vol. 45, (36) 3707-3717.
Van Gelder IC, Rienstra M, Bunting KV, Casado-Arroyo R, Caso V, Crijns HJGM, De Potter TJR, Dwight J, Guasti L, Hanke T, Jaarsma T, Lettino M, Løchen M-L, Lumbers RT, Maesen B, Mølgaard I, Rosano GMC, Sanders P, Schnabel RB, Suwalski P, Svennberg E, Tamargo J, Tica O, Traykov V, Tzeis S, Kotecha D, Dagres N, Rocca B, Ahsan S and Ameri P (2024). 2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). Oxford University Press (OUP) European Heart Journal vol. 45, (36) 3314-3414.
Gualtieri A, Gomez-Corral L, Nicholson J, Tan R, Guasti L and Gaston-Massuet C (2024). Efnb2 controls pituitary development by regulating the pituitary stem cell niche. Bioscientifica Endocrine Abstracts
Bellomo AR, Rotondi G, Rago P, Bloise S, Di Ruzza L, Zingoni A, Di Valerio S, Valzano E, Di Pierro F, Cazzaniga M, Bertuccioli A, Guasti L, Zerbinati N and Lubrano R (2024). Effect of Bifidobacterium bifidum Supplementation in Newborns Born from Cesarean Section on Atopy, Respiratory Tract Infections, and Dyspeptic Syndromes: A Multicenter, Randomized, and Controlled Clinical Trial. MDPI Microorganisms vol. 12, (6)
2023
Read J, Guasti L, Paganoni A and Howard S (2023). Rare variants in the MECP2 gene in girls with central precocious puberty. Bioscientifica Endocrine Abstracts
Ruiz-Babot G, Eceiza A, Abollo-Jiménez F, Malyukov M, Carlone DL, Borges K, Da Costa AR, Qarin S, Matsumoto T, Morizane R, Skarnes WC, Ludwig B, Chapple PJ, Guasti L, Storr HL, Bornstein SR and Breault DT (2023). Generation of glucocorticoid-producing cells derived from human pluripotent stem cells. Elsevier Cell Reports Methods vol. 3, (11)
Canton APM, Tinano FR, Guasti L, Montenegro LR, Ryan F, Shears D, de Melo ME, Gomes LG, Piana MP, Brauner R, Aguilar RE, Escribano-Munôz A, Paganoni A, Read J, Korbonits M, Seraphim CE, Costa SS, Krepischi AC, Jorge AAL, David A, Kaisinger LR, Ong KK, Perry JRB, Abreu AP, Kaiser UB, Argente J, Mendonca BB, Brito VN, Howard SR and Latronico AC (2023). Rare variants in the MECP2 gene in girls with central precocious puberty: a translational cohort study. Elsevier The Lancet Diabetes & Endocrinology vol. 11, (8) 545-554.
Mistry JN, Silvennoinen S, Zaman F, Sävendahl L, Mariniello K, Hall C, Howard SR, Dunkel L, Sankilampi U and Guasti L (2023). The crosstalk between FGF21 and GH leads to weakened GH receptor signaling and IGF1 expression and is associated with growth failure in very preterm infants. Frontiers Frontiers in Endocrinology vol. 14,
Williams JL, Smith C, Hall C, Khaled Z, Maharaj A, Kwong R, Pittaway J, Casas J, Parvanta L, Abdel-Aziz TE, Palazzo F, Chung T-T, Guasti L, Metherell L and Prasad R (2023). Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma. Oxford University Press (OUP) European Journal of Endocrinology vol. 188, (1)
2022
Hasan S, Delicata F, Guasti L, Duranti C, Haidar FM, Arcangeli A, Imbrici P, Pessia M, Valentino M and D'Adamo MC (2022). Locus Coeruleus Neurons’ Firing Pattern Is Regulated by ERG Voltage-Gated K+ Channels. MDPI International Journal of Molecular Sciences vol. 23, (23)
Canton A, Tinano F, Guasti L, Montenegro L, Argente J, Ryan F, Shears D, Melo ME, Gomes L, Piana M, Brauner R, Spino R, Escribano-Muñoz A, Paganoni A, Korbonits M, Krepischi A, Costa S, Seraphim CE, Faria A, Mendonca B, Brito V, Howard S and Latronico AC (2022). RF14 | PSAT120 X-Linked Central Precocious Puberty Associated with MECP2 Defects. The Endocrine Society Journal of the Endocrine Society vol. 6, (Supplement_1) a643-a644.
Mariniello K, Pittaway J, Hadjidemetriou I, Borges K, Doroszko M, Doghman M, Lalli E, Rahman N, Breault D, Rognoni E and Guasti L (2022). Delta-like non-canonical notch ligand 1 (DLK1)-expressing adrenocortical progenitor cells: role in adrenal turnover, remodeling and tumorigenesis in mice. Bioscientifica Endocrine Abstracts
Pittaway J, Mariniello K, Altieri B, Sbiera I, Sbiera S, Chung T-T, Abdel-Azziz T, DiMarco A, Palazzo F, Akker SA, Landwehr L-S, Ronchi C, Parvanta L, Drake W, Kroiss M, Fassnacht M and Guasti L (2022). Delta-like non-canonical Notch ligand 1 (DLK1) - a novel biomarker in adrenocortical carcinoma. Bioscientifica Endocrine Abstracts
E RJ, Pinheiro-Machado CA, Tinano F, Guasti L, Ribeiro ML, Ryan F, Shears D, Paganoni A, Korbonits M, Jorge A, David A, Bilharinho MB, Nahime BV, Claudia LA and Howard SR (2022). Variants in Methyl-CpG-binding protein 2 (MECP2) are associated with X-Linked Central Precocious Puberty. Bioscientifica Endocrine Abstracts
Guasti L and Pittaway JFH (2022). A new recipe for TARTs? One step closer in identifying the origin of testicular adrenal rest tumours. Oxford University Press (OUP) European Journal of Endocrinology vol. 187, (6) c3-c4.
Mariniello K, Guasti L and Rognoni E (2022). DLK1 expressing cells mark a population of progenitor cells in the adrenal cortex and contribute to the zonation of the adrenal gland. Bioscientifica Endocrine Abstracts
Williams J, Smith C, Hall C, Khaled Z, Maharaj A, Kwong R, Pittaway J, Casas J, Parvanta L, Abdel-Aziz T, Palazzo F, Chung T-T, Guasti L, Metherell L and Prasad R (2022). Elevated SGPL1 expression is associated with increased metabolic rate in cells and reduced survival in individuals with adrenocortical carcinoma. Bioscientifica Endocrine Abstracts
2021
Saengkaew T, Ruiz-Babot G, David A, Mancini A, Mariniello K, Cabrera CP, Barnes MR, Dunkel L, Guasti L and Howard SR (2021). Whole exome sequencing identifies deleterious rare variants in CCDC141 in familial self-limited delayed puberty. Springer Nature npj Genomic Medicine vol. 6, (1)
Howard S, Saengkaew T, Dunkel L and Guasti L (2021). Dominant mutations in CCDC141 are found by ehole rxome dequencing to be a common cause of self-limited delayed puberty. Bioscientifica Endocrine Abstracts
Pittaway JFH, Lipsos C, Mariniello K and Guasti L (2021). The role of delta-like non-canonical Notch ligand 1 (DLK1) in cancer. Bioscientifica Endocrine Related Cancer vol. 28, (12) r271-r287.
van der Grinten HLC, Speiser PW, Ahmed SF, Arlt W, Auchus RJ, Falhammar H, Flück CE, Guasti L, Huebner A, Kortmann BBM, Krone N, Merke DP, Miller WL, Nordenström A, Reisch N, Sandberg DE, Stikkelbroeck NMML, Touraine P, Utari A, Wudy SA and White PC (2021). Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management. The Endocrine Society Endocrine Reviews vol. 43, (1) 91-159.
Saengkaew T, Mancini A, Ruiz-Babot G, Cabrera CP, Barnes MR, Dunkel L, Guasti L and Howard S (2021). Defects in the GnRH Neuronal Migration factor, CCDC141, Lead to Self-Limited Delayed Puberty. The Endocrine Society Journal of the Endocrine Society vol. 5, (Supplement_1) a665-a666.
Mariniello K and Guasti L (2021). Towards novel treatments for adrenal diseases: Cell- and gene therapy-based approaches. Elsevier Molecular and Cellular Endocrinology vol. 524,
2020
Mancini A, Howard SR, Marelli F, Cabrera CP, Barnes MR, Sternberg MJE, Leprovots M, Hadjidemetriou I, Monti E, David A, Wehkalampi K, Oleari R, Lettieri A, Vezzoli V, Vassart G, Cariboni A, Bonomi M, Garcia MI, Guasti L and Dunkel L (2020). LGR4 deficiency results in delayed puberty through impaired Wnt/β-catenin signaling. American Society for Clinical Investigation JCI Insight vol. 5, (11)
Mariniello K, Rognoni E and Guasti L (2020). SUN-LB43 DLK1 Expressing Cells Contribute to the Zonation of the Adrenal Gland. The Endocrine Society Journal of the Endocrine Society vol. 4, (Supplement_1) sun-lb43.
2019
Mancini A, Howard SR, Cabrera CP, Barnes MR, David A, Wehkalampi K, Vassert G, Cariboni A, Garcia MI, Guasti L and Dunkel L (2019). Defects in LGR4 Wnt-[beta]-catenin signalling impair GnRH network development, leading to delayed puberty. Bioscientifica Endocrine Abstracts
Mariniello K, Ruiz-Babot G, McGaugh EC, Nicholson JG, Gualtieri A, Gaston-Massuet C, Nostro MC and Guasti L (2019). Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine System. Frontiers Frontiers in Endocrinology vol. 10,
Gualtieri A, Nicholson J, Tan R, Jimenez F, Dattani M, Guasti L and Gaston-Massuet C (2019). Efnb2 controls pituitary gland development by regulating proliferation of the pituitary stem/progenitor cells and EMT within the pituitary stem cell niche. Bioscientifica Endocrine Abstracts
SR H, R O, A P, V C, A F, G R-B, LA M, CP C, MR B, K W, L G, C R, A C and L D (2019). HS6ST1 insufficiency causes self-limited delayed puberty in contrast with other GnRH deficiency genes. Bioscientifica
A M, SR H, CP C, MR B, A D, K W, S H, A L, L G, SR O and L D (2019). EAP1 regulation of GnRH promoter activity is important for human pubertal timing. Bioscientifica
Liew S-Y, Akker SA, Guasti L and Pittaway JFH (2019). Glucocorticoid replacement therapies: past, present and future. Elsevier Current Opinion in Endocrine and Metabolic Research vol. 8, 152-159.
Hadjidemetriou I, Mariniello K, Ruiz-Babot G, Pittaway J, Mancini A, Mariannis D, Gomez-Sanchez CE, Parvanta L, Drake WM, Chung TT, Abdel-Aziz TE, DiMarco A, Palazzo FF, Wierman ME, Kiseljak-Vassiliades K, King PJ and Guasti L (2019). DLK1/PREF1 marks a novel cell population in the human adrenal cortex. Elsevier The Journal of Steroid Biochemistry and Molecular Biology vol. 193,
Novoselova TV, King PJ, Guasti L, Metherell LA, Clark AJL and Chan LF (2019). ACTH signalling and adrenal development: lessons from mouse models. Bioscientifica Endocrine Connections vol. -1, (aop) r122-r130.
Maharaj A, Maudhoo A, Chan LF, Novoselova T, Prasad R, Metherell LA and Guasti L (2019). Isolated glucocorticoid deficiency: Genetic causes and animal models. Journal of Steroid Biochemistry and Molecular Biology vol. 189, 73-80.
Papathomas TG, Sun N, Chortis V, Taylor AE, Arlt W, Richter S, Eisenhofer G, Ruiz-Babot G, Guasti L and Walch AK (2019). Novel methods in adrenal research: a metabolomics approach. Springer Nature Histochemistry and Cell Biology vol. 151, (3) 201-216.
Pittaway JFH and Guasti L (2019). Pathobiology and genetics of adrenocortical carcinoma. Bioscientifica Journal of Molecular Endocrinology vol. 62, (2) r105-r119.
Mancini A, Howard SR, Cabrera CP, Barnes MR, David A, Wehkalampi K, Heger S, Lomniczi A, Guasti L, Ojeda SR and Dunkel L (2019). EAP1 regulation of GnRH promoter activity is important for human pubertal timing. Oxford University Press (OUP) Human Molecular Genetics vol. 28, (8) 1357-1368.
2018
Maharaj A, Buonocore F, Meimaridou E, Ruiz-Babot G, Guasti L, Peng H-M, Capper CP, Burgos-Tirado N, Prasad R, Hughes CR, Maudhoo A, Crowne E, Cheetham TD, Brain CE, Suntharalingham JP, Striglioni N, Yuksel B, Gurbuz F, Gupta S, Lindsay R, Couch R, Spoudeas HA, Guran T, Johnson S, Fowler DJ, Conwell LS, McInerney-Leo AM, Drui D, Cariou B and Lopez-Siguero JP (2018). Predicted Benign and Synonymous Variants in CYP11A1 Cause Primary Adrenal Insufficiency Through Missplicing. The Endocrine Society Journal of the Endocrine Society vol. 3, (1) 201-221.
G R-B, M B, I H, SJ A, DR T, L G, NF T, U S, CG Z, HL S, MR D, EF G, WM D, GS C, PJ K, LA M and SR B (2018). Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells. Bioscientifica
Guasti L, New SE, Hadjidemetriou I, Palmiero M and Ferretti P (2018). Plasticity of human adipose-derived stem cells - relevance to tissue repair. Int J Dev Biol vol. 62, (6-7-8) 431-439.
Howard SR, Oleari R, Poliandri A, Chantzara V, Fantin A, Ruiz-Babot G, Metherell LA, Cabrera CP, Barnes MR, Wehkalampi K, Guasti L, Ruhrberg C, Cariboni A and Dunkel L (2018). HS6ST1 Insufficiency Causes Self-Limited Delayed Puberty in Contrast With Other GnRH Deficiency Genes. The Endocrine Society The Journal of Clinical Endocrinology & Metabolism vol. 103, (9) 3420-3429.
Novoselova TV, Hussain M, King PJ, Guasti L, Metherell LA, Charalambous M, Clark AJL and Chan LF (2018). MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation. Wiley The FASEB Journal vol. 32, (11) 6186-6196.
Balyura M, Gelfgat E, Steenblock C, Androutsellis-Theotokis A, Ruiz-Babot G, Guasti L, Werdermann M, Ludwig B, Bornstein T, Schally AV, Brennand A and Bornstein SR (2018). Expression of progenitor markers is associated with the functionality of a bioartificial adrenal cortex. Public Library of Science PLoS One vol. 13, (3) e0194643-e0194643.
Ruiz-Babot G, Balyura M, Hadjidemetriou I, Ajodha SJ, Taylor DR, Ghataore L, Taylor NF, Schubert U, Ziegler CG, Storr HL, Druce MR, Gevers EF, Drake WM, Srirangalingam U, Conway GS, King PJ, Metherell LA, Bornstein SR and Guasti L (2018). Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells. Elsevier Cell Reports vol. 22, (5) 1236-1249.
2017
Howard SR, Guasti L, Poliandri A, David A, Cabrera CP, Barnes MR, Wehkalampi K, O’Rahilly S, Aiken CE, Coll AP, Ma M, Rimmington D, Yeo GSH and Dunkel L (2017). Contributions of Function-Altering Variants in Genes Implicated in Pubertal Timing and Body Mass for Self-Limited Delayed Puberty. The Endocrine Society The Journal of Clinical Endocrinology & Metabolism vol. 103, (2) 649-659.
Howard S, Andre V, Guasti L, Cabrera C, Barnes M, Cariboni A and Dunkel L (2017). Patients with self-limited delayed puberty harbour mutations in multiple genes controlling GnRH neuronal development. Bioscientifica Endocrine Abstracts
Maharaj A, Buonocore F, Meimaridou E, Ruiz-Babot G, Guasti L, Peng H-M, Capper C, Prasad R, Crowne E, Cheetham T, Brain C, Suntharalingham J, Striglioni N, Yuksel B, Gurbuz F, Auchus R, Spoudeas H, Guran T, Johnson S, Fowler D, Duncan E, Conwell L, Drui D, Cariou B, Siguero JPL, Harris M, Donaldson M, Achermann J and Metherell L (2017). Predicted benign and silent SNPs in CYP11A1 cause primary adrenal insufficiency through missplicing. Bioscientifica Endocrine Abstracts
Katugampola H, King PJ, Chatterjee S, Meso M, Duncan AJ, Achermann JC, Guasti L, Ghataore L, Taylor NF, Allen R, Marlene S, Aquilina J, Abbara A, Jaysena CN, Dhillo WS, Dunkel L, Sankilampi U and Storr HL (2017). Kisspeptin is a novel regulator of human fetal adrenocortical development and function – a finding with important implications for the human feto-placental unit. The Journal of Clinical Endocrinology & Metabolism
Tufton N, Roncaroli F, Hadjudemetriou I, Dang MN, Denes J, Guasti L, Thom M, Powell M, Baldeweg SE, Fersht N and Korbonits M (2017). Metastatic pituitary carcinoma in an SDHB mutation positive patient. Bioscientifica Endocrine Abstracts
Tufton N, Roncaroli F, Hadjidemetriou I, Dang MN, Dénes J, Guasti L, Thom M, Powell M, Baldeweg SE, Fersht N and Korbonits M (2017). Pituitary Carcinoma in a Patient with an SDHB Mutation. Endocr Pathol vol. 28, (4) 320-325.
Poliandri A, Miller D, Howard S, Nobles M, Ruiz-Babot G, Harmer S, Tinker A, McKay T, Guasti L and Dunkel L (2017). Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells. Elsevier Molecular and Cellular Endocrinology vol. 447, 12-22.
METHERELL LA, Prasad R, Storr HL, Guasti L, Maharaj A, Meimaridou E and Hadjidemetriou I (2017). Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome. American Society for Clinical Investigation Journal of Clinical Investigation
2016
GUASTI L (2016). Towards reconstruction of epithelialized cartilages from autologous adipose tissue-derived stem cells. Wiley: 12 months Journal of Tissue Engineering and Regenerative Medicine
Ruiz-Babot G, Hadjidemetriou I, Ajodha SJ, Ghataore L, Taylor D, Taylor N, Balyura M, Bornstein SR and Guasti L (2016). Generation of human urine-derived steroidogenic cells through lineage conversion: A new technology to study the adrenal gland. Bioscientifica Endocrine Abstracts
Novoselova TV, Larder R, Rimmington D, Lelliott C, Wynn E, Gorrigan RJ, Tate P, Guasti L, Sanger Mouse Genetics Project T, O'Rahilly S, Clark AJL, Logan DW, Coll AP and Chan LF (2016). Loss of Mrap2 is associated with Sim 1 deficiency and increased circulating cholesterol. Journal of Endocrinology JOE-16-0057-JOE-16-0057.
HOWARD SR, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell LA, Sternberg MJE, Cabrera CP, Warren H, Barnes M, Quinton R, de Roux N, Young J, Guiochon-Mantel A, Wehkalampi K, Andre V, Gothilf Y, Cariboni A and Dunkel L (2016). IGSF10 mutations dysregulate gonadotropin‐releasing hormone neuronal migration resulting in delayed puberty. Wiley EMBO Molecular Medicine vol. 8, (6) 626-42.
2015
Howard S, Poliandre A, Storr HL, Metherell LA, Cabrera C, Warren H, Barnes M, Wehkalampi K, Guasti L and Dunkel L (2015). Mutations in HS6ST1 cause self-limited delayed puberty (DP) in addition to idiopathic hypogonadotropic hypogonadism (IHH). Bioscientifica Endocrine Abstracts
Howard S, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell L, Cabrera C, Warren H, Barnes M, Wehkalampi K, Gothilf Y, Andre V, Cariboni A and Dunkel L (2015). Mutations in IGSF10 cause self-limited delayed puberty. Bioscientifica Endocrine Abstracts
Babot GR, Hadjidemetriou I, Ajodha SJ, Taylor D, Taylor N and Guasti L (2015). Lineage conversion of human cells to an adrenocortical phenotype: a new technology to study the adrenal gland. Bioscientifica Endocrine Abstracts
Hadjidemetriou I, Ruiz-Babot G, Gomez-Sanchez C, King P and Guasti L (2015). Unveiling the complexity of the undifferentiated zone in the human adrenal cortex. Bioscientifica Endocrine Abstracts
Howard S, Poliandri A, Storr H, Metherell L, Cabrera C, Barnes M, Warren H, Wehkalampi K, Guasti L and Dunkel L (2015). Mutations in HS6ST1 are causal in self-limited delayed puberty as well as idiopathic hypogonadotropic hypogonadism. Bioscientifica Endocrine Abstracts
Howard S, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell L, Sternberg M, Cabrera C, Warren H, Barnes M, Wehkalampi K, Andre V, Gothilf Y, Cariboni A and Dunkel L (2015). Mutations in IGSF10 cause self-limited delayed puberty, via disturbance of GnRH neuronal migration. Bioscientifica Endocrine Abstracts
Dentali F, Sironi AP, Gianni M, Orlandini F, Guasti L, Grandi AM, Franchini M, Ageno W and Squizzato A (2015). Gender Difference in Efficacy and Safety of Nonvitamin K Antagonist Oral Anticoagulants in Patients with Nonvalvular Atrial Fibrillation or Venous Thromboembolism: A Systematic Review and a Meta-Analysis of the Literature. Thieme Seminars in Thrombosis and Hemostasis vol. 41, (07) 774-787.
Ruiz-Babot G, Hadjidemetriou I, King PJ and Guasti L (2015). New Directions for the Treatment of Adrenal Insufficiency. Frontiers Frontiers in Endocrinology vol. 6,
Permunian ET, Riva N, Guasti L and Squizzato A (2015). Cangrelor for the treatment of arterial thrombosis: pharmacokinetics/pharmacodynamics and clinical data. Taylor & Francis Expert Opinion on Drug Metabolism & Toxicology vol. 11, (4) 625-637.
2014
Galli L, Gerdes VEA, Guasti L and Squizzato A (2014). Thrombosis Associated with Viral Hepatitis. Xia & He Publishing Journal of Clinical and Translational Hepatology vol. 2, (4) 234-239.
Guasti L, Silvennoinen S, Bulstrode NW, Ferretti P, Sankilampi U and Dunkel L (2014). Elevated FGF21 leads to attenuated postnatal linear growth in preterm infants through GH resistance in chondrocytes. J Clin Endocrinol Metab vol. 99, (11) E2198-E2206.
Katugampola H, Halder W, Ganatra R, Dunkel L, Storr H, Guasti L and King P (2014). Expression of Sonic hedgehog signalling components in the developing human adrenal cortex. Bioscientifica Endocrine Abstracts
Donadini MP, Dentali F, Squizzato A, Guasti L and Ageno W (2014). Unsuspected pulmonary embolism in cancer patients: a narrative review with pooled data. Springer Nature Internal and Emergency Medicine vol. 9, (4) 375-384.
Marino F, Maresca AM, Castiglioni L, Cosentino M, Maio RC, Schembri L, Klersy C, Mongiardi C, Robustelli Test L, Grandi AM and Guasti L (2014). Simvastatin down-regulates the production of Interleukin-8 by neutrophil leukocytes from dyslipidemic patients. Springer Nature BMC Cardiovascular Disorders vol. 14, (1)
Ferrari M, Guasti L, Maresca A, Mirabile M, Contini S, Grandi AM, Marino F and Cosentino M (2014). Association between statin-induced creatine kinase elevation and genetic polymorphisms in SLCO1B1, ABCB1 and ABCG2. Springer Nature European Journal of Clinical Pharmacology vol. 70, (5) 539-547.
Howard S, Guasti L, Storr H, Metherell L, Cariboni A, Barnes M, Cabrera C, Wehkalampi K and Dunkel L (2014). A novel gene affecting the timing of puberty. Bioscientifica Endocrine Abstracts
Campiotti L, Maresca A, Guasti L and Grandi AM (2014). Tirosine Kinase Inhibitors Adverse Events. Oxford University Press (OUP) The Oncologist vol. 19, (3) 306-306.
Guasti L, Vagaska B, Bulstrode NW, Seifalian AM and Ferretti P (2014). Chondrogenic differentiation of adipose tissue-derived stem cells within nanocaged POSS-PCU scaffolds: a new tool for nanomedicine. Nanomedicine vol. 10, (2) 279-289.
Grandi AM, Nicolini E, Rizzi L, Caputo S, Annoni F, Cremona AM, Marchesi C, Guasti L, Maresca AM and Grossi P (2014). Dyslipidemia in HIV‐positive patients: a randomized, controlled, prospective study on ezetimibe+fenofibrate versus pravastatin monotherapy. Wiley Journal of the International AIDS Society vol. 17, (1)
Falcone C, Matrone B, Bozzini S, Guasti L, Falcone R, Benzi A, Colonna A, Savulescu I, Vailati A and Pelissero G (2014). Time-Domain Heart Rate Variability in Coronary Artery Disease Patients Affected by Thyroid Dysfunction. International Heart Journal (Japanese Heart Journal) International Heart Journal vol. 55, (1)
Dentali F, Gianni M, Mumoli N, Cei M, Bertolini A, Guasti L and Ageno W (2014). Efficacy and safety of patent foramen ovale closure in patients with a cryptogenic stroke: Systematic review and meta-analysis. Thieme Thrombosis and Haemostasis vol. 111, (04) 773-776.
2013
Bozzato S, Squizzato A, Donadini MP, Guasti L, Dentali F and Ageno W (2013). Patient selection for thromboprophylaxis in medical inpatients. Taylor & Francis Expert Review of Cardiovascular Therapy vol. 11, (12) 1639-1647.
Dentali F, Riva N, Turato S, Grazioli S, Squizzato A, Steidl L, Guasti L, Grandi AM and Ageno W (2013). Pulmonary embolism severity index accurately predicts long‐term mortality rate in patients hospitalized for acute pulmonary embolism. Elsevier Journal of Thrombosis and Haemostasis vol. 11, (12) 2103-2110.
Guasti L, Cavlan D, Cogger K, Banu Z, Shakur A, Latif S and King PJ (2013). Dlk1 upregulates Gli1 expression in male rat adrenal capsule cells through the activation of β1 integrin and ERK1-2. Endocrine Society Endocrinology vol. 154, (12) 4675-4684.
Riva N, Ageno W, Guasti L and Squizzato A (2013). Commentary. Scientific Scholar Journal of Neurosciences in Rural Practice vol. 04, (03) 367-369.
Squizzato A, Rancan E, Dentali F, Bonzini M, Guasti L, Steidl L, Mathis G and Ageno W (2013). Diagnostic accuracy of lung ultrasound for pulmonary embolism: a systematic review and meta‐analysis. Elsevier Journal of Thrombosis and Haemostasis vol. 11, (7) 1269-1278.
Guasti L, Candy Sze WC, McKay T, Grose R and King PJ (2013). FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development. Mol Cell Endocrinol vol. 371, (1-2) 182-188.
Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL and Metherell LA (2013). Familial glucocorticoid deficiency: New genes and mechanisms. Mol Cell Endocrinol vol. 371, (1-2) 195-200.
Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL and Metherell LA (2013). Familial glucocorticoid deficiency: New genes and mechanisms. Molecular and Cellular Endocrinology vol. 371, (1-2) 195-200.
Donadini MP, Ageno W, Guasti L and Squizzato A (2013). Certoparin for the treatment and prevention of thrombosis: pharmacological profile and results from clinical studies. Taylor & Francis Expert Opinion on Drug Metabolism & Toxicology vol. 9, (7) 901-909.
Yates R, Katugampola H, Cavlan D, Cogger K, Meimaridou E, Hughes C, Metherell L, Guasti L and King P (2013). Adrenocortical development, maintenance, and disease. Curr Top Dev Biol vol. 106, 239-312.
Falcone C, Bozzini S, Guasti L, D’Angelo A, Capettini AC, Paganini EM, Falcone R, Moia R, Gazzaruso C and Pelissero G (2013). Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease. Wiley The Scientific World JOURNAL vol. 2013, (1)
Marino F, Guasti L, Tozzi M, Schembri L, Castiglioni L, Molteni E, Piffaretti G, Castelli P and Cosentino M (2013). Gene Expression of Adhesion Molecules in Endothelial Cells from Patients with Peripheral Arterial Disease Is Reduced after Surgical Revascularization and Pharmacological Treatment. Hindawi International Journal of Vascular Medicine vol. 2013, (1)
2012
Marino F, Maresca AM, Cosentino M, Castiglioni L, Rasini E, Mongiardi C, Maio RC, Legnaro M, Schembri L, Dentali F, Grandi AM and Guasti L (2012). Angiotensin II type 1 and type 2 receptor expression in circulating monocytes of diabetic and hypercholesterolemic patients over 3-month rosuvastatin treatment. Springer Nature Cardiovascular Diabetology vol. 11, (1)
Cogger K, Guasti L, Ashworth R, Brennan C, Beales P, Marion V and King P (2012). The role of primary cilia in mouse adrenal and zebrafish interrenal development. Springer Nature Cilia vol. 1, (Suppl 1)
Squizzato A, Guasti L and Ageno W (2012). Statins are better than fibrates in patients with a previous venous thromboembolism. Elsevier Thrombosis Research vol. 130, (6) 831-832.
Nicolini E, Martegani G, Maresca AM, Marchesi C, Dentali F, Lazzarini A, Speroni S, Guasti L, Bertolini A, Venco A and Grandi AM (2012). Left ventricular remodeling in patients with metabolic syndrome: Influence of gender. Elsevier Nutrition Metabolism and Cardiovascular Diseases vol. 23, (8) 771-775.
Meimaridou E, Kowalczyk J, Guasti L, Hughes CR, Wagner F, Frommolt P, Nürnberg P, Mann NP, Banerjee R, Saka HN, Chapple JP, King PJ, Clark AJL and Metherell LA (2012). Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency. Nat Genet vol. 44, (7) 740-742.
Guasti L, Prasongchean W, Kleftouris G, Mukherjee S, Thrasher A, Bulstrode N and Ferretti P (2012). High plasticity of pediatric adipose-derived stem cells: too much for selective skeletogenic differentiation? Stem Cells Trans Med vol. 1, (5) 384-395.
Hughes CR, Guasti L, Meimaridou E, Chuang C-H, Schimenti JC, King PJ, Costigan C, Clark AJL and Metherell LA (2012). MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans. JOURNAL OF CLINICAL INVESTIGATION vol. 122, (3) 814-820.
Marchesi C, Dentali F, Nicolini E, Maresca AM, Tayebjee MH, Franz M, Guasti L, Venco A, Schiffrin EL, Lip GYH and Grandi AM (2012). Plasma levels of matrix metalloproteinases and their inhibitors in hypertension. Wolters Kluwer Journal of Hypertension vol. 30, (1) 3-16.
2011
Grandi AM, Laurita E, Marchesi C, Maresca AM, Solbiati F, Bernasconi A, Marogna M, Salina C, Nicolini E, Guasti L, Colombo F and Venco A (2011). OSA, metabolic syndrome and CPAP: Effect on cardiac remodeling in subjects with abdominal obesity. Elsevier Respiratory Medicine vol. 106, (1) 145-152.
Cooray SN, Guasti L and Clark AJL (2011). The E3 ubiquitin ligase Mahogunin ubiquitinates the melanocortin 2 receptor. Endocrinology vol. 152, (11) 4224-4231.
Maroni L, Guasti L, Castiglioni L, Marino F, Contini S, Macchi V, De Leo A, Gaudio G, Tozzi M, Grandi AM, Cosentino M and Venco A (2011). Lipid Targets During Statin Treatment in Dyslipidemic Patients Affected by Nonalcoholic Fatty Liver Disease. Elsevier The American Journal of the Medical Sciences vol. 342, (5) 383-387.
Grandi AM, Nicolini E, Giola M, Gianni M, Maresca AM, Marchesi C, Guasti L, Balsamo ML, Venco A and Grossi PA (2011). Left ventricular remodelling in asymptomatic HIV infection on chronic HAART: comparison between hypertensive and normotensive subjects with and without HIV infection. Springer Nature Journal of Human Hypertension vol. 26, (10) 570-576.
Gorrigan RJ, Guasti L, King P, Clark AJ and Chan LF (2011). Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland. J Mol Endocrinol vol. 46, (3) 227-232.
Guasti L, Paul A, Laufer E and King P (2011). Localization of Sonic hedgehog secreting and receiving cells in the developing and adult rat adrenal cortex. Mol Cell Endocrinol vol. 336, (1-2) 117-122.
Dentali F, Gianni M, Squizzato A, Ageno W, Castiglioni L, Maroni L, Hylek EM, Grandi AM, Cazzani E, Venco A and Guasti L (2011). Use of statins and recurrence of atrial fibrillation after catheter ablation or electrical cardioversion. Thieme Thrombosis and Haemostasis vol. 106, (02) 363-370.
Guasti L, Dentali F, Castiglioni L, Maroni L, Marino F, Squizzato A, Ageno W, Gianni M, Gaudio G, Grandi AM, Cosentino M and Venco A (2011). Neutrophils and clinical outcomes in patients with acute coronary syndromes and/or cardiac revascularisation. Thieme Thrombosis and Haemostasis vol. 106, (04) 591-599.
2010
Dentali F and Guasti L (2010). Are Statins Effective in High-Risk Primary Prevention? American Medical Association (AMA) JAMA Internal Medicine vol. 170, (22) 2042-2044.
Igreja S, Chahal HS, King P, Bolger GB, Srirangalingam U, Guasti L, Chapple JP, Trivellin G, Gueorguiev M, Guegan K, Stals K, Khoo B, Kumar AV, Ellard S, Grossman AB, Korbonits M and International FIPA Consortium (2010). Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families. Hum Mutat vol. 31, (8) 950-960.
Guasti L, Marino F, Congiu T, Tozzi M, Schembri L, Maio RC, Castiglioni L, Maroni L, Castelli P, Quacci DE, Dell'Orbo C, Grandi AM, Lecchini S, Cosentino M and Venco A (2010). Laminar Pattern of Mineral Calcium-Phosphorus Deposits in a Human Carotid Plaque. Wolters Kluwer Circulation vol. 121, (17) 1971-1973.
Congiu T, Schembri L, Tozzi M, Guasti L, Maio RC, Cosentino M and Marino F (2010). Scanning electron microscopy examination of endothelium morphology in human carotid plaques. Elsevier Micron vol. 41, (5) 532-536.
2009
Squizzato A, Galli M, Romualdi E, Dentali F, Kamphuisen PW, Guasti L, Venco A and Ageno W (2009). Statins, fibrates, and venous thromboembolism: a meta-analysis. Oxford University Press (OUP) European Heart Journal vol. 31, (10) 1248-1256.
Marino F, Guasti L, Tozzi M, Maio RC, Castiglioni L, Rasini E, Schembri L, Maroni L, Legnaro M, De Leo A, Piffaretti G, Castelli P, Venco A, Lecchini S and Cosentino M (2009). Angiotensin Type 1 Receptor Expression and Interleukin-8 Production in Polymorphonuclear Leukocytes of Patients With Peripheral Arterial Disease. Wolters Kluwer Journal of Cardiovascular Pharmacology vol. 54, (6) 520-525.
Guasti L, Marino F, Cosentino M, Maroni L, Maresca AM, Colombo F, Maio RC, Castiglioni L, Saporiti F, Loraschi A, Gaudio G, Bernasconi A, Laurita E, Grandi AM and Venco A (2009). Cytokine production from peripheral blood mononuclear cells and polymorphonuclear leukocytes in patients studied for suspected obstructive sleep apnea. Springer Nature Sleep and Breathing vol. 15, (1) 3-11.
Guasti L, Mainardi LT, Baselli G, Simoni C, Cimpanelli M, Braga SS, Pedretti R, Castiglioni L, Maroni L, Codari R, Gaudio G, Grandi AM, Marino F, Cosentino M and Venco A (2009). Components of arterial systolic pressure and RR-interval oscillation spectra in a case of baroreflex failure, a human open-loop model of vascular control. Springer Nature Journal of Human Hypertension vol. 24, (6) 417-426.
Guasti L, Richardson D, Jhaveri M, Eldeeb K, Barrett D, Elphick MR, Alexander SPH, Kendall D, Michael GJ and Chapman V (2009). Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain. Mol Pain vol. 5,
Chan LF, Webb TR, Chung T-T, Meimaridou E, Cooray SN, Guasti L, Chapple JP, Egertová M, Elphick MR, Cheetham ME, Metherell LA and Clark AJL (2009). MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. Proc Natl Acad Sci U S A vol. 106, (15) 6146-6151.
2008
Guasti L, Simoni C, Mainardi L, Crespi C, Cimpanelli MG, Klersy C, Gaudio G, Codari R, Maroni L, Marino F, Cosentino M, Grandi AM, Cerutti S and Venco A (2008). Lack of relationship between cardiovascular reactivity to mental stress and autonomic modulation of the sinoatrial node in normotensive and hypertensive male subjects. Elsevier International Journal of Psychophysiology vol. 71, (3) 258-263.
Pessia M, Servettini I, Panichi R, Guasti L, Grassi S, Arcangeli A, Wanke E and Pettorossi VE (2008). ERG voltage-gated K+ channels regulate excitability and discharge dynamics of the medial vestibular nucleus neurones. Journal of Physiology vol. 586, (20) 4877-4890.
King PJ, Guasti L and Laufer E (2008). Hedgehog signalling in endocrine development and disease. J ENDOCRINOL vol. 198, (3) 439-450.
Guasti L, Crociani O, Redaelli E, Pillozzi S, Polvani S, Masselli M, Mello T, Galli A, Amedei A, Wymore RS, Wanke E and Arcangeli A (2008). Identification of a posttranslational mechanism for the regulation of hERG1 K+ channel expression and hERG1 current density in tumor cells. Mol Cell Biol vol. 28, (16) 5043-5060.
Schembri L, Congiu T, Tozzi M, Guasti L, Cosentino M and Marino F (2008). Scanning Electron Microscopy Examination and Elemental Analysis of Atherosclerotic Calcifications in a Human Carotid Plaque. Wolters Kluwer Circulation vol. 117, (23) e479-e480.
Marino F, Guasti L, Cosentino M, Rasini E, Ferrari M, Maio RC, Loraschi A, Cimpanelli MG, Schembri L, Legnaro M, Molteni E, Crespi C, Crema F, Venco A and Lecchini S (2008). Simvastatin treatment in subjects at high cardiovascular risk modulates AT1R expression on circulating monocytes and T lymphocytes. Wolters Kluwer Journal of Hypertension vol. 26, (6) 1147-1155.
Guasti L, Marino F, Cosentino M, Maio RC, Rasini E, Ferrari M, Castiglioni L, Klersy C, Gaudio G, Grandi AM, Lecchini S and Venco A (2008). Prolonged statin-associated reduction in neutrophil reactive oxygen species and angiotensin II type 1 receptor expression: 1-year follow-up. Oxford University Press (OUP) European Heart Journal vol. 29, (9) 1118-1126.
Grandi AM, Solbiati F, Laurita E, Maresca AM, Nicolini E, Marchesi C, Gianni M, Guasti L and Venco A (2008). Effects of Dual Blockade of Renin–Angiotensin System on Concentric Left Ventricular Hypertrophy in Essential Hypertension: a Randomized, Controlled Pilot Study. Oxford University Press (OUP) American Journal of Hypertension vol. 21, (2) 231-237.
2007
Marchesi C, Maresca AM, Solbiati F, Franzetti I, Laurita E, Nicolini E, Gianni M, Guasti L, Marnini P, Venco A and Grandi AM (2007). Masked Hypertension in Type 2 Diabetes Mellitus. Oxford University Press (OUP) American Journal of Hypertension vol. 20, (10) 1079-1084.
Guasti L, Marino F, Cosentino M, Cimpanelli M, Rasini E, Piantanida E, Vanoli P, De Palma D, Crespi C, Klersy C, Maroni L, Loraschi A, Colombo C, Simoni C, Bartalena L, Lecchini S, Grandi AM and Venco A (2007). Pain Perception, Blood Pressure Levels, and Peripheral Benzodiazepine Receptors in Patients Followed for Differentiated Thyroid Carcinoma: A Longitudinal Study in Hypothyroidism and During Hormone Treatment. Wolters Kluwer The Clinical Journal of Pain vol. 23, (6) 518-523.
Marino F, Guasti L, Cosentino M, Ferrari M, Rasini E, Maio RC, Cimpanelli MG, Cereda E, Crespi C, Simoni C, Restelli D, Venco A and Lecchini S (2007). Angiotensin II Type 1 Receptor Expression in Polymorphonuclear Leukocytes From High-Risk Subjects: Changes After Treatment With Simvastatin. Wolters Kluwer Journal of Cardiovascular Pharmacology vol. 49, (5) 299-305.
Grandi AM, Laurita E, Marchesi C, Maresca A, Solbiati F, Nicolini E, Gianni M, Guasti L and Venco A (2007). Family History of Hypertension Influences Left Ventricular Diastolic Function During Chronic Antihypertensive Therapy. Oxford University Press (OUP) American Journal of Hypertension vol. 20, (4) 410-415.
Guasti L, Simoni C, Scamoni C, Sarzi Braga S, Crespi C, Cimpanelli M, Grandi AM, Pedretti R, Mainardi LT, Tomei G and Venco A (2007). An unusual case presenting with hypertensive crisis. Springer Nature Internal and Emergency Medicine vol. 2, (1)
Furlan F, Taccola G, Grandolfo M, Guasti L, Arcangeli A, Nistri A and Ballerini L (2007). ERG conductance expression modulates the excitability of ventral horn GABAergic interneurons that control rhythmic oscillations in the developing mouse spinal cord. Journal of Neuroscience vol. 27, (4) 919-928.
2006
Guasti L, Marino F, Cosentino M, Cimpanelli M, Maio RC, Klersy C, Crespi C, Restelli D, Simoni C, Franzetti I, Gaudio G, Marnini P, Grandi AM, Lecchini S and Venco A (2006). Simvastatin treatment modifies polymorphonuclear leukocyte function in high-risk individuals: a longitudinal study. Wolters Kluwer Journal of Hypertension vol. 24, (12) 2423-2430.
Guasti L, Marino F, Cosentino M, Cimpanelli M, Piantanida E, Mainardi LT, Vanoli P, De Palma D, Bombelli R, Ferrari M, Crespi C, Simoni C, Klersy C, Gaudio G, Maroni L, Grandi AM, Tanda M, Bartalena L, Cerutti S, Lecchini S and Venco A (2006). Changes in Autonomic Modulation to the Heart and Intracellular Catecholamines. Karger Publishers Hormone Research in Paediatrics vol. 67, (4) 171-178.
Grandi AM, Laurita E, Solbiati F, Marchesi C, Maresca AM, Nicolini E, Guasti L and Venco A (2006). Angiotensin-converting Enzyme Inhibitors Influence Left Ventricular Mass and Function Independently of the Antihypertensive Effect. Wolters Kluwer Journal of Cardiovascular Pharmacology vol. 48, (5) 207-211.
Guasti L, Simoni C, Scamoni C, Braga SS, Crespi C, Cimpanelli M, Gaudio G, Pedretti R, Mainardi LT, Grandi AM, Tomei G and Venco A (2006). Mixed cranial nerve neuroma revealing itself as baroreflex failure. Elsevier Autonomic Neuroscience vol. 130, (1-2) 57-60.
Restano R, Korolkova Y, Diochot S, Gurrola G, Guasti L, Possani L, Lazdunski E, Arcangeli A and Wanke E (2006). Species diversity and peptide toxin blocking selectively of ERG subfamily K+ channels in the central nervous system. Mol Pharm vol. 69, (5) 1673-83.
Rasini E, Cosentino M, Marino F, Legnaro M, Ferrari M, Guasti L, Venco A and Lecchini S (2006). Angiotensin II type 1 receptor expression on human leukocyte subsets: A flow cytometric and RT-PCR study. Elsevier Peptides vol. 134, (2-3) 69-74.
Grandi AM, Maresca AM, Giudici E, Laurita E, Marchesi C, Solbiati F, Nicolini E, Guasti L and Venco A (2006). Metabolic Syndrome and Morphofunctional Characteristics of the Left Ventricle in Clinically Hypertensive Nondiabetic Subjects. Oxford University Press (OUP) American Journal of Hypertension vol. 19, (2) 199-205.
Marino F, Guasti L, Cosentino M, Piazza DD, Simoni C, Bianchi V, Piantanida E, Saporiti F, Cimpanelli MG, Crespi C, Vanoli P, Palma DD, Klersy C, Frigo GM, Bartalena L, Venco A and Lecchini S (2006). Thyroid hormone and thyrotropin regulate intracellular free calcium concentrations in human polymorphonuclear leukocytes: in vivo and in vitro studies. SAGE Publications International Journal of Immunopathology and Pharmacology vol. 19, (1) 149-160.
2005
Grandi AM, Piantanida E, Franzetti I, Bernasconi M, Maresca A, Marnini P, Guasti L and Venco A (2005). Effect of Glycemic Control on Left Ventricular Diastolic Function in Type 1 Diabetes Mellitus. Elsevier The American Journal of Cardiology vol. 97, (1) 71-76.
Guasti L, Cilia E, Crociani O, Hofmann G, Polvani S, Becchetti A, Wanke E, Tempia F and Arcangeli A (2005). Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits. J Comp Neurol vol. 491, (2) 157-174.
Marino F, Guasti L, Cosentino M, De Piazza D, Simoni C, Piantanida E, Cimpanelli M, Klersy C, Bartalena L, Venco A and Lecchini S (2005). Thyroid hormone regulation of cell migration and oxidative metabolism in polymorphonuclear leukocytes: Clinical evidence in thyroidectomized subjects on thyroxine replacement therapy. Elsevier Life Sciences vol. 78, (10) 1071-1077.
Cherubini A, Hofmann G, Pillozzi S, Guasti L, Crociani O, Cilia E, Di Stefano P, Degani S, Balzi M, Olivotto M, Wanke E, Becchetti A, Defilippi P, Wymore R and Arcangeli A (2005). Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling. Mol Biol Cell vol. 16, (6) 2972-2983.
Guasti L, Simoni C, Mainardi LT, Cimpanelli M, Crespi C, Gaudio G, Clersy C, Grandi AM, Cerutti S and Venco A (2005). Circadian blood pressure variability is associated with autonomic and baroreflex-mediated modulation of the sinoatrial node. Peeters Publishers Acta Cardiologica vol. 60, (3) 319-324.
Guasti L, Simoni C, Mainardi L, Crespi C, Cimpanelli M, Klersy C, Gaudio G, Grandi AM, Cerutti S and Venco A (2005). Global link between heart rate and blood pressure oscillations at rest and during mental arousal in normotensive and hypertensive subjects. Elsevier Autonomic Neuroscience vol. 120, (1-2) 80-87.
Gaudio G, Guasti L, Schizzarotto A, Simoni C, Crespi C, Cimpanelli M, Klersy C, Grandi AM, Riganti G and Venco A (2005). Changes in Plasma Lipids During Renin-Angiotensin System Blockade by Combination Therapy (Enalapril Plus Valsartan) in Patients With Diabetes and Hypertension. Wolters Kluwer Journal of Cardiovascular Pharmacology vol. 45, (4) 362-366.
Furlan* F, Guasti* L, Avossa D, Becchetti A, Cilia E, Ballerini L and Arcangeli A (2005). Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro. Neuroscience vol. 135, (4) 1179-1192.
Grandi AM, Solbiati F, Laurita E, Cassinerio E, Marchesi C, Piperno F, Maresca A, Guasti L and Venco A (2005). Isolated office hypertension: A 3‐year follow‐up study. Taylor & Francis Blood Pressure vol. 14, (5) 298-305.
2004
Arcangeli A, Becchetti A, Cherubini A, Crociani O, Defilippi P, Guasti L, Hofmann G, Pillozzi S, Olivotto M and Wanke E (2004). Physical and functional interaction between integrins and hERG potassium channels. Biochem Soc Trans vol. 32, (Pt 5) 826-827.
Arcangeli A, Becchetti A, Cherubini A, Crociani O, Defilippi P, Guasti L, Hofmann G, Pillozzi S, Olivotto M and Wanke E (2004). Physical and functional interaction between integrins and hERG potassium channels. Biochemical Society Transactions vol. 32, (5) 826-827.
Grandi AM, Laurita E, Selva E, Piantanida E, Imperiale D, Giovanella L, Guasti L and Venco A (2004). Natriuretic peptides as markers of preclinical cardiac disease in obesity. Wiley European Journal of Clinical Investigation vol. 34, (5) 342-348.
Lastraioli* E, Guasti* L, Crociani O, Polvani S, Hofmann G, Witchel H, Bencini L, Calistri M, Messerini L, Scatizzi M, Moretti R, Wanke E, Olivotto M, Mugnai G and Arcangeli A (2004). herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells. Cancer Res vol. 64, (2) 606-611.
2003
Crociani O, Guasti L, Balzi M, Becchetti A, Wanke E, Olivotto M, Wymore RS and Arcangeli A (2003). Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells. J Biol Chem vol. 278, (5) 2947-2955.
2002
Gullo F, Ales E, Rosati B, Lecchi M, Masi A, Guasti L, Cano‐Abad MF, Arcangeli A, Lopez MG and Wanke E (2002). ERG K+ channel blockade enhances firing and epinephrine secretion in rat chromaffin cells: the missing link to LQT2‐related sudden death? Wiley The FASEB Journal vol. 17, (2) 330-332.
Grandi AM, Imperiale D, Santillo R, Barlocco E, Bertolini A, Guasti L and Venco A (2002). Aldosterone Antagonist Improves Diastolic Function in Essential Hypertension. Wolters Kluwer Hypertension vol. 40, (5) 647-652.
Pillozzi S, Brizzi MF, Balzi M, Crociani O, Cherubini A, Guasti L, Bartolozzi B, Becchetti A, Wanke E, Bernabei PA, Olivotto M, Pegoraro L and Arcangeli A (2002). HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors. Leukemia vol. 16, (9) 1791-1798.
Guasti L, Zanotta D, Mainardi LT, Petrozzino MR, Grimoldi P, Garganico D, Diolisi A, Gaudio G, Klersy C, Grandi AM, Simoni C and Cerutti S (2002). Hypertension-related hypoalgesia, autonomic function and spontaneous baroreflex sensitivity. Elsevier Autonomic Neuroscience vol. 99, (2) 127-133.
Grandi AM, Broggi R, Jessula A, Laurita E, Cassinerio E, Piperno F, Bertolini A, Guasti L and Venco A (2002). Relation of extent of nocturnal blood pressure decrease to cardiovascular remodeling in never-treated patients with essential hypertension. Elsevier The American Journal of Cardiology vol. 89, (10) 1193-1196.
Guasti L, Zanotta D, Diolisi A, Garganico D, Simoni C, Gaudio G, Grandi AM and Venco A (2002). Changes in pain perception during treatment with angiotensin converting enzyme-inhibitors and angiotensin II type 1 receptor blockade. Wolters Kluwer Journal of Hypertension vol. 20, (3) 485-491.
Cherubini A, Pillozzi S, Hofmann G, Crociani O, Guasti L, Lastraioli E, Polvani S, Masi A, Becchetti A, Wanke E, Olivotto M and Arcangeli A (2002). HERG K+ channels and β1 integrins interact through the assembly of a macromolecular complex. Annals of the New York Academy of Sciences vol. 973, 559-561.
2001
Grandi AM, Broggi R, Colombo S, Santillo R, Imperiale D, Bertolini A, Guasti L and Venco A (2001). Left Ventricular Changes in Isolated Office Hypertension: A Blood Pressure–Matched Comparison With Normotension and Sustained Hypertension. American Medical Association (AMA) JAMA Internal Medicine vol. 161, (22) 2677-2681.
Guasti L, Petrozzino MR, Mainardi LT, Grimoldi P, Zanotta D, Garganico D, Diolisi A, Simoni C, Grandi AM, Gaudio G, Cerutti S and Venco A (2001). Autonomic function and baroreflex sensitivity during angiotensin-converting enzyme inhibition or angiotensin II AT-1 receptor blockade in essential hypertensive patients. Peeters Publishers Acta Cardiologica vol. 56, (5) 289-295.
Grandi AM, Santillo R, Bertolini A, Imperiale D, Broggi R, Colombo S, Selva E, Jessula A, Guasti L and Venco A (2001). Microalbuminuria as a marker of preclinical diastolic dysfunction in never-treated essential hypertensives. Oxford University Press (OUP) American Journal of Hypertension vol. 14, (7) 644-648.
Grandi AM, Zanzi P, Broggi R, Fachinetti A, Guasti L, Ceriani L and Venco A (2001). Longitudinal Changes of Insulin Sensitivity in Essential Hypertension: Influence of Blood Pressure Control and Familial Predisposition to Hypertension. The Endocrine Society The Journal of Clinical Endocrinology & Metabolism vol. 86, (7) 3027-3031.
Hofmann G, Bernabei PA, Crociani O, Cherubini A, Guasti L, Lastraioli E, Polvani S, Bartolozzi B, Solazzo V, Gragnani L, Rosati B, Defilippi P, Wanke E, Olivotto M and Arcangeli A (2001). HERG K channels activation during β1 integrin-mediated adhesion to fibronectin induces an up regulation of αvβ3 integrin in the preosteoclastic leukemia cell line. J Biol Chem 4923-31.
2000
Hofmann G, Bernabei PA, Crociani O, Cherubini A, Guasti L, Pillozzi S, Lastraioli E, Polvani S, Bartolozzi B, Solazzo V, Gragnani L, Defilippi P, Rosati B, Wanke E, Olivotto M and Arcangeli A (2000). HERG K+ Channels Activation during β1Integrin-mediated Adhesion to Fibronectin Induces an Up-regulation of αvβ3 Integrin in the Preosteoclastic Leukemia Cell Line FLG 29.1*. Elsevier Journal of Biological Chemistry vol. 276, (7) 4923-4931.
Grandi A, Zanzi P, Piantanida E, Gaudio G, Bertolini A, Guasti L and Venco A (2000). Obesity and left ventricular diastolic function: noninvasive study in normotensives and newly diagnosed never-treated hypertensives. Springer Nature International Journal of Obesity vol. 24, (8) 954-958.
Grandi AM, Santillo R, Zanzi P, Broggi R, Imperiale D, Colombo S, Bertolini A, Jessula A, Selva E, Guasti L and Venco A (2000). Microalbuminuria in never-treated hypertensives: Lack of relationship to hyperinsulinemia and genetic predisposition to hypertension. Oxford University Press (OUP) American Journal of Hypertension vol. 13, (4) 353-358.
1999
Grandi AM, Zanzi P, Fachinetti A, Gaudio G, Ceriani L, Bertolini A, Guasti L and Venco A (1999). Insulin and Diastolic Dysfunction in Lean and Obese Hypertensives. Wolters Kluwer Hypertension vol. 34, (6) 1208-1214.
Guasti L, Zanotta D, Petrozzino MR, Grimoldi P, Diolisi A, Garganico D, Gaudio G, Grandi AM, Bertolini A and Venco A (1999). Relationship between dental pain perception and 24 hour ambulatory blood pressure. Wolters Kluwer Journal of Hypertension vol. 17, (12) 1799-1804.
Guasti L, Gaudio G, Zanotta D, Grimoldi P, Petrozzino MR, Tanzi F, Bertolini A, Grandi AM and Venco A (1999). Relationship between a genetic predisposition to hypertension, blood pressure levels and pain sensitivity. Wolters Kluwer Pain vol. 82, (3) 311-317.
Guasti L, Grimoldi P, Mainardi LT, Petrozzino MR, Piantanida E, Garganico D, Diolisi A, Zanotta D, Bertolini A, Ageno W, Grandi AM, Cerutti S and Venco A (1999). Autonomic function and baroreflex sensitivity during a normal ovulatory cycle in humans. Acta Cardiologica vol. 54, (4) 209-213.
Grandi AM, Broggi R, Zanzi P, Gaudio G, Santillo R, Lamponi M, Bertolini A, Guasti L and Venco A (1999). Individualized versus standardized analysis of ambulatory blood pressure profile: relationship with left ventricular characteristics. Wolters Kluwer Blood Pressure Monitoring vol. 4, (1) 7-11.
1998
Guasti L, Diolisi A, Gaudio G, Grimoldi P, Petrozzino R, Uslenghi S, Bertolini A, Grandi A and Venco A (1998). Reactivity of blood pressure to mental arithmetic stress test, stress-test recovery time, and ambulatory blood pressure in hypertensive and normotensive subjects. Blood Pressure Monitoring vol. 3, (5) 275-280.
Grandi A, Gaudio G, Fachinetti A, Piantanida E, Zanzi P, Ceriani L, Guasti L and Venco A (1998). Insulin sensitivity in obese normotensive adults: influence of family history of hypertension. Springer Nature International Journal of Obesity vol. 22, (9) 910-914.
Guasti L, Grimoldi P, Diolisi A, Petrozzino MR, Gaudio G, Grandi AM, Rossi MG and Venco A (1998). Treatment With Enalapril Modifies the Pain Perception Pattern in Hypertensive Patients. Wolters Kluwer Hypertension vol. 31, (5) 1146-1150.
1997
GRANDI AM, GAUDIO G, FACHINETTI A, ZANZI P, BIANCHI L, CERIANI L, GUASTI L and VENCO A (1997). Influence of family history of hypertension on insulin sensitivity in lean and obese hypertensive subjects. Wiley European Journal of Clinical Investigation vol. 27, (9) 774-779.
Grandi AM, Zanzi P, Ceriani L, Gaudio G, Bertolini A, Giovanella L, Guasti L, Roncari G and Venco A (1997). Relationship Between Left Ventricular Diastolic Function and Atrial Natriuretic Factor in Never-Treated Mild Hypertensives. Oxford University Press (OUP) American Journal of Hypertension vol. 10, (8) 946-950.
Grandi AM, Pinotti G, Morandi E, Zanzi P, Bulgheroni P, Guasti L, Bertolini A and Venco A (1997). Noninvasive evaluation of cardiotoxicity of 5-fluorouracil and low doses of folinic acid: A one-year follow-up study. Elsevier Annals of Oncology vol. 8, (7) 705-708.
Guasti L, Grimoldi P, Ceriani L, Gaudio G, Bertolini A, Giovanella L, Grandi A, Roncari G and Venco A (1997). Atrial natriuretic peptide and 24 h blood pressure. Blood Pressure Monitoring vol. 2, (2) 89-92.
Guasti L, Marino F, Gaudio G, Cosentino M, Diolisi A, Bertolini A, Grandi AM, Lecchini S, Frigo G and Venco A (1997). Ambulatory blood pressure, nocturnal blood pressure reduction and plasma catecholamines. Acta Cardiologica vol. 52, (6) 485-494.
Grandi AM, Bignotti M, Bertolini A, Gaudio G, Zanzi P, Guasti L, Nardo B and Venco A (1997). Clinical Feasibility of Echocardiographic Automated Border Detection in Monitoring Left Ventricular Response to Acute Changes of Preload in Normal Subjects. Karger Publishers Cardiology vol. 88, (4) 393-396.
1996
Guasti L, Cattaneo R, Daneri A, Bianchi L, Gaudio G, Regazzi MB, Grandi AM, Bertolini A, Restelli E and Venco A (1996). Endogenous beta-endorphins in hypertension: Correlation with 24-hour ambulatory blood pressure. Elsevier Journal of the American College of Cardiology vol. 28, (5) 1243-1248.
Grandi AM, Gaudio G, Fachinetti A, Bianchi L, Nardo B, Zanzi P, Ceriani L, Guasti L and Venco A (1996). Hyperinsulinemia, Family History of Hypertension, and Essential Hypertension. Oxford University Press (OUP) American Journal of Hypertension vol. 9, (8) 732-738.
1995
Bossi PM, Guasti L, Merlo B, Verga R, Cattaneo R, Gaudio G, Bianchi L, Zanzi P, Grandi AM and Venco A (1995). Effects of arithmetic mental stress test on hypertension-related hypalgesia. Wolters Kluwer Journal of Hypertension vol. 13, (12) 1631-1635.
Grandi AM, Bignotti M, Gaudio G, Zanzi P, Guasti L and Venco A (1995). Ambulatory Blood Pressure and Left Ventricular Changes During Antihypertensive Treatment. Wolters Kluwer Journal of Cardiovascular Pharmacology vol. 26, (5) 737-741.
Guasti L, Cattaneo R, Rinaldi O, Rossi MG, Bianchi L, Gaudio G, Grandi AM, Gorini G and Venco A (1995). Twenty-four-hour noninvasive blood pressure monitoring and pain perception. Wolters Kluwer Hypertension vol. 25, (6) 1301-1305.
Bignotti M, Grandi AM, Gaudio G, Guasti L and Venco A (1995). One-year antihypertensive treatment with amlodipine: effects on 24-hour blood pressure and left ventricular anatomy and function. Acta Cardiologica vol. 50, (2) 135-142.
1993
Falcone C, Guasti L, Ochan M, Codega S, Tortorici M, Angoli L, Bergamaschi R and Montemartini C (1993). Beta-endorphins during coronary angioplasty in patients with silent or symptomatic myocardial ischemia. Elsevier Journal of the American College of Cardiology vol. 22, (6) 1614-1620.
1991
Specchia G, Falcone C, Traversi E, La Rovere MT, Guasti L, De Micheli G, Ardissino D and De Servi S (1991). Mental stress as a provocative test in patients with various clinical syndromes of coronary heart disease. Circulation vol. 83, (4 Suppl) ii108-ii114.
1990
Salerno JA, Guasti L, Panciroli C, Chimienti M, Previtali M and Bobba P (1990). Syncope and sudden death due to vasospastic myocardial ischemia in young sportmen. Bollettino Della Societa Italiana Di Cardiologia vol. 35, (1 Suppl) 69-72.
Specchia G, Falcone C, Tortorici M, Cioffi P, Ghio S, Ciardelli L, Guasti L and Rondanelli R (1990). Silent Ischemia during PTCA: Its Relationship with Exercise-Induced Silent Ischemia and the Possible Role for Beta-Endorphins. Karger Publishers Advances in Cardiology vol. 37, 165-175.
1989
Costantini M, Chimienti M, Zardini M, Klersy C, Guasti L and Salerno JA (1989). An electrophysiologic and electropharmacological study of functional properties of the bundle of Kent in Wolff-Parkinson-White syndrome. Bollettino Della Societa Italiana Di Cardiologia vol. 34, (4) 365-374.
1988
Falcone C, Sconocchia R, Guasti L, Codega S, Montemartini C and Specchia G (1988). Dental pain threshold and angina pectoris in patients with coronary artery disease. Elsevier Journal of the American College of Cardiology vol. 12, (2) 348-352.
Klersy C, Marangoni E, Salerno JA, Guasti L, Chimienti M, Morellini MC, li Bergolis M, Moizi M, Tronconi L and Bobba P (1988). Intravenous flecainide in Wolff-Parkinson-White syndrome: a test for evaluation of the refractory period of the anomalous pathway. Comparison with ajmaline. Bollettino Della Societa Italiana Di Cardiologia vol. 33, (5) 531-535.
Falcone C, Specchia G, Rondanelli R, Guasti L, Corsico G, Codega S and Montemartini C (1988). Correlation between beta-endorphin plasma levels and anginal symptoms in patients with coronary artery disease. Elsevier Journal of the American College of Cardiology vol. 11, (4) 719-723.
Salerno JA, Klersy C, Minzioni G, Guasti L, Chimienti M, Zardini M and Viganò M (1988). Therapy of arrhythmia by ablation technics with catheters and with surgical technics. Bollettino Della Societa Italiana Di Cardiologia vol. 33, (3) 237-241.
1987
Salerno JA, Klersy C, Chimienti M, Zardini M, Guasti L, Marangoni E and Previtali M (1987). Paroxysmal ventricular tachycardias. Bollettino Della Societa Italiana Di Cardiologia vol. 32, (12) 1675-1683.
CHIMIENTI M, MOIZI M, SALERNO JA, KLERSY C, GUASTI L, PREVITALI M, MARANGONI E, MONTEMARTINI C and BOBBA P (1987). Electrophysiologic and clinical effects of intravenous and oral encainide in patients with Wolff-Parkinson-White syndrome and paroxysmal atrial fibrillation. Oxford University Press (OUP) European Heart Journal vol. 8, (3) 282-290.
Chimienti M, Moizi M, Klersy C, Guasti L and Salerno JA (1987). A modified ajmaline test for prediction of the effective refractory period of the accessory pathway in the wolff-parkinson-white syndrome. Elsevier The American Journal of Cardiology vol. 59, (1) 164-165.
1986
Salerno JA, Previtali M, Panciroli C, Klersy C, Chimienti M, Regazzi Bonora M, Marangoni E, Falcone C, Guasti L and Campana C (1986). Ventricular arrhythmias during acute myocardial ischaemia in man. The role and significance of R-ST-T alternans and the prevention of ischaemic sudden death by medical treatment. European Heart Journal vol. 7 Suppl A, 63-75.