Dr Lucy Norling
Versus Arthritis Senior Fellow
CPM ECR Mentoring, Journal Club and Public Engagement Lead
Centre for Biochemical Pharmacology
Faculty of Medicine and Dentistry, Queen Mary University of London
Faculty of Medicine and Dentistry, Queen Mary University of London
Research
Musculoskeletal, joint-on-a-chip, Omega-3 lipid mediators, Inflammation resolution, Extracellular vesicles, Leukocyte Trafficking
Interests
My research group is interested in how omega-3 derived lipid mediators can protect and repair joint tissues. I have a keen interest in the development of human in vitro models to mimic various aspects of the inflammatory response including leukocyte-endothelial interactions, cell chemotaxis, phagocytosis and efferocytosis as well as the development of musculoskeletal models.Publications
2024
Thomas BL, Montero‐Melendez T, Oggero S, Kaneva MK, Chambers D, Pinto AL, Nerviani A, Lucchesi D, Austin‐Williams S, Hussain MT, Pitzalis C, Allen B, Malcangio M, Dell'Accio F, Norling LV and Perretti M (2024). Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis. Wiley Arthritis & Rheumatology vol. 76, (12) 1705-1718. Hussain MT, Austin-Williams S, Wright TD, Dhawan UK, Pinto AL, Cooper D and Norling LV (2024). β1-Integrin-Mediated Uptake of Chondrocyte Extracellular Vesicles Regulates Chondrocyte Homeostasis. MDPI International Journal of Molecular Sciences vol. 25, (9) 2023
Norling LV and Cooper D (2023). Being old and female is an inflammatory combination. Oxford University Press (OUP) Journal of Leukocyte Biology vol. 114, (4) 299-300. Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN and Perretti M (2023). Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. American Society for Clinical Investigation JCI Insight vol. 8, (3) Chen J, Austin-Williams S, O'Riordan CE, Claria-Ribas P, Sugimoto MA, Norling LV, Thiemermann C and Perretti M (2023). Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction. Karger Publishers Journal of Innate Immunity vol. 15, (1) 548-561. 2022
Norling LV and Halade GV (2022). Helpful inflammation turned harmful in non-communicable diseases. Elsevier Current Opinion in Pharmacology vol. 67, Qin CX, Norling LV, Vecchio EA, Brennan EP, May LT, Wootten D, Godson C, Perretti M and Ritchie RH (2022). Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35. Wiley British Journal of Pharmacology vol. 179, (19) 4617-4639. Oggero S, Godec T, van Gorp R, Pinto AL, Schurgers LJ, Reutelingsperger C, Sever P, Norling LV, Perretti M and Gupta A (2022). Role of plasma extracellular vesicles in prediction of cardiovascular risk and alterations in response to statin therapy in hypertensive patients. Wolters Kluwer Journal of Hypertension vol. 40, (8) 1522-1529. Cecconello C, Ribas PC and Norling LV (2022). Chapter 4 Resolving acute inflammation; what happens when inflammation goes haywire? How can it get back in line? Diet, Inflammation, and Health Elsevier 2021
Iqbal AJ, Krautter F, Blacksell IA, Wright RD, Austin‐Williams SN, Voisin M, Hussain MT, Law HL, Niki T, Hirashima M, Bombardieri M, Pitzalis C, Tiwari A, Nash GB, Norling LV and Cooper D (2021). Galectin‐9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin‐dependent manner. Wiley The FASEB Journal vol. 36, (1) Chen J, Norling LV, Mesa JG, Silva MDP, Burton SE, Reutelingsperger C, Perretti M and Cooper D (2021). Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 118, (38) Austin-Williams S, Hussain MT, Oggero S and Norling LV (2021). Enhancing Extracellular Vesicles for therapeutic treatment of arthritic joints. Elsevier Free Radical Biology and Medicine vol. 175, 80-94. Chen J, Norling LV and Cooper D (2021). Cardiac Dysfunction in Rheumatoid Arthritis: The Role of Inflammation. MDPI Cells vol. 10, (4) Oggero S, de Gaetano M, Marcone S, Fitzsimons S, Pinto AL, Ikramova D, Barry M, Burke D, Montero‐Melendez T, Cooper D, Burgoyne T, Belton O, Norling LV, Brennan EP, Godson C and Perretti M (2021). Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity. Wiley Journal of Extracellular Vesicles vol. 10, (6) 2020
Brouwers H, Jónasdóttir HS, Kuipers ME, Kwekkeboom JC, Auger JL, Gonzalez-Torres M, López-Vicario C, Clària J, Freysdottir J, Hardardottir I, Garrido-Mesa J, Norling LV, Perretti M, Huizinga TWJ, Kloppenburg M, Toes REM, Binstadt B, Giera M and Ioan-Facsinay A (2020). Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid. The American Association of Immunologists The Journal of Immunology vol. 205, (10) 2840-2849. Souza PR, Walker ME, Goulding NJ, Dalli J, Perretti M and Norling LV (2020). The GPR40 Agonist GW9508 Enhances Neutrophil Function to Aid Bacterial Clearance During E. coli Infections. Frontiers Media Frontiers in Immunology vol. 11, 573019-573019. Hussain MT, Iqbal AJ and Norling LV (2020). The Role and Impact of Extracellular Vesicles in the Modulation and Delivery of Cytokines during Autoimmunity. MDPI International Journal of Molecular Sciences vol. 21, (19) Norling LV and Perretti M (2020). Proresolving lipid mediators enhance PMN-mediated bacterial clearance. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 117, (17) 9148-9150. Norling L, Cooper D, Law H, Wright R and Iqbal A (2020). A pro-resolving role for Galectin-1 in acute inflammation. Frontiers Media Frontiers in Pharmacology vol. 11, (274) Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin MB, Vinci C, Law HL, Perretti M, Norling LV, Azevedo HS and Nissim A (2020). Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody. Frontiers Media Frontiers in Immunology vol. 11, Padovan MG and Norling LV (2020). Pro-resolving lipid mediators in sepsis and critical illness. Ovid Technologies (Wolters Kluwer Health) Current Opinion in Clinical Nutrition and Metabolic Care 1-1. 2019
Oggero S, Austin-Williams S and Norling LV (2019). The contrasting role of extracellular vesicles in vascular inflammation and tissue repair. Frontiers Media Frontiers in Pharmacology vol. 10, 2018
Rhys HI, Dell'Accio F, Pitzalis C, Moore A, Norling LV and Perretti M (2018). Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. Elsevier EBioMedicine vol. 29, 60-69. Oggero S, Norling L and Perretti M (2018). Microvesicles in cardiovascular inflammation: markers or mediators of cardiovascular diseases? Japanese Pharmacological Society Proceedings for Annual Meeting of The Japanese Pharmacological Society vol. WCP2018, 2017
Perretti M and Norling LV (2017). Actions of SPM in regulating host responses in arthritis. Elsevier Molecular Aspects of Medicine vol. 58, 57-64. Piovezan AP, Batisti AP, Benevides MLACS, Turnes BL, Martins DF, Kanis L, Duarte ECW, Cavalheiro AJ, Bueno PCP, Seed MP, Norling LV, Cooper D, Headland S, Souza PRPS and Perretti M (2017). Hydroalcoholic crude extract of Casearia sylvestris Sw. reduces chronic post-ischemic pain by activation of pro-resolving pathways. Elsevier Journal of Ethnopharmacology vol. 204, 179-188. Norling LV, Ly L and Dalli J (2017). Resolving inflammation by using nutrition therapy: roles for specialized proresolving mediators. Curr Opin Clin Nutr Metab Care vol. 20, (2) 145-152. Perretti M, Cooper D, Dalli J and Norling LV (2017). Immune resolution mechanisms in inflammatory arthritis. Nat Rev Rheumatol vol. 13, (2) 87-99. Souza PR, Jones HR and Norling LV (2017). Novel immunoregulatory mediators produced from omega-3 fatty acids. Nutrition, Immunity, and Infection 2016
Wright RD, Souza PR, Flak MB, Thedchanamoorthy P, Norling LV and Cooper D (2016). Galectin-3-null mice display defective neutrophil clearance during acute inflammation., Editors: Montaner LJ. The Society for Leukocyte Biology J Leukoc Biol Ross EA, Naylor AJ, O'Neil JD, Crowley T, Ridley ML, Crowe J, Smallie T, Tang TJ, Turner JD, Norling LV, Dominguez S, Perlman H, Verrills NM, Kollias G, Vitek MP, Filer A, Buckley CD, Dean JL and Clark AR (2016). Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression. Elsevier Annals of the Rheumatic Diseases vol. 76, (3) Arnardottir HH, Dalli J, Norling LV, Colas RA, Perretti M and Serhan CN (2016). Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. American Association of Immunologists Journal of Immunology vol. 197, (6) 2362-2368. Souza PR and Norling LV (2016). Implications for eicosapentaenoic acid- and docosahexaenoic acid-derived resolvins as therapeutics for arthritis. European Journal of Pharmacology vol. 785, 165-173. Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN and Perretti M (2016). Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. American Society for Clinical Investigation JCI Insight vol. 1, (5) 2015
Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A, Dell'Accio F, Pitzalis C, Oliani SM, Jan LY and Perretti M (2015). Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. American Association for the Advancement of Science (AAAS) Science Translational Medicine vol. 7, (315) Canova DF, Pavlov AM, Norling LV, Gobbetti T, Brunelleschi S, Le Fauder P, Cenac N, Sukhorukov GB and Perretti M (2015). Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response. Elsevier Journal of Controlled Release vol. 217, 284-292. Headland SE and Norling LV (2015). The resolution of inflammation: Principles and challenges. Seminars in Immunology vol. 27, (3) 149-160. Headland S, Norling L, Kim A, Jones H, Jan L and Perretti M (2015). Neutrophil‐Derived Microvesicles Migrate into Cell‐Impenetrable Cartilage to Protect the Joint During Inflammatory Arthritis. Wiley The FASEB Journal vol. 29, (S1) 2014
Montero-Melendez T, Madeira MFM, Norling LV, Alsam A, Curtis MA, da Silva TA and Perretti M (2014). Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3. Am J Pathol vol. 184, (8) 2333-2341. Cash JL, Norling LV and Perretti M (2014). Resolution of inflammation: targeting GPCRs that interact with lipids and peptides. Drug Discov Today vol. 19, (8) 1186-1192. Headland SE, Jones HR, D'Sa ASV, Perretti M and Norling LV (2014). Cutting-edge analysis of extracellular microparticles using ImageStream(X) imaging flow cytometry. Sci Rep vol. 4, Dalli J, Norling LV, Montero-Melendez T, Federici Canova D, Lashin H, Pavlov AM, Sukhorukov GB, Hinds CJ and Perretti M (2014). Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. EMBO Mol Med vol. 6, (1) 27-42. Burgmaier M, Schutters K, Willems B, Van der Vorst EPC, Kusters D, Chatrou M, Norling L, Biessen EAL, Cleutjens J, Perretti M, Schurgers LJ and Reutelingsperger CPM (2014). AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE-/- mice. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE vol. 18, (10) 2117-2124. 2013
Norling LV and Dalli J (2013). Microparticles are novel effectors of immunity. Curr Opin Pharmacol vol. 13, (4) 570-575. Dalli J, Montero-Melendez T, Norling LV, Yin X, Hinds C, Haskard D, Mayr M and Perretti M (2013). Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. Mol Cell Proteomics vol. 12, (8) 2205-2219. Norling LV and Perretti M (2013). The role of omega-3 derived resolvins in arthritis. Curr Opin Pharmacol vol. 13, (3) 476-481. Norling LV and Perretti M (2013). Control of myeloid cell trafficking in resolution. J Innate Immun vol. 5, (4) 367-376. 2012
Yazid S, Norling LV and Flower RJ (2012). Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti-inflammatory system. Prostaglandins Other Lipid Mediat vol. 98, (3-4) 94-100. Norling LV, Dalli J, Flower RJ, Serhan CN and Perretti M (2012). Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler Thromb Vasc Biol vol. 32, (8) 1970-1978. Gil-Villa AM, Norling LV, Serhan CN, Cordero D, Rojas M and Cadavid A (2012). Aspirin triggered-lipoxin A4 reduces the adhesion of human polymorphonuclear neutrophils to endothelial cells initiated by preeclamptic plasma. Prostaglandins Leukot Essent Fatty Acids vol. 87, (4-5) 127-134. 2011
Norling LV, Spite M, Yang R, Flower RJ, Perretti M and Serhan CN (2011). Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. J Immunol vol. 186, (10) 5543-5547. Norling LV, Spite M, Yang R, Flower RJ, Perretti M and Serhan CN (2011). Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing. J IMMUNOL vol. 186, (10) 5543-5547. 2010
Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. INT J MOL MED vol. 26, (6) 913-918. Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. Spandidos Publications International Journal of Molecular Medicine vol. 26, (6) 913-918. Norling LV and Serhan CN (2010). Profiling in resolving inflammatory exudates identifies novel anti-inflammatory and pro-resolving mediators and signals for termination. J Intern Med vol. 268, (1) 15-24. Ayoub SS, Norling LV, Leoni G, Cooper D and Perretti M (2010). Cell Adhesion Molecules. Fundamentals of Inflammation Cambridge University Press (CUP) Norling LV, Dalli J, Flower RJ, Serhan CN and Perretti M (2010). Resolvin D1 limits PMN recruitment to inflammatory loci: receptor dependent bioactions. FASEB JOURNAL vol. 24, Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. International Journal of Molecular Medicine vol. 26, (6) 913-918. 2009
Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M and Serhan CN (2009). Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. NATURE vol. 461, (7268) 1287-U125. Piqueras L, Sanz MJ, Perretti M, Morcillo E, Norling L, Mitchell JA, Li Y and Bishop-Bailey D (2009). Activation of PPAR beta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release. J LEUKOCYTE BIOL vol. 86, (1) 115-122. Norling LV, Perretti M and Cooper D (2009). Endogenous galectins and the control of the host inflammatory response. J Endocrinol vol. 201, (2) 169-184. 2008
Dalli J, Norling LV, Renshaw D, Cooper D, Leung KY and Perretti M (2008). Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. BLOOD vol. 112, (6) 2512-2519. Cooper D, Norling LV and Perretti M (2008). Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. J LEUKOCYTE BIOL vol. 83, (6) 1459-1466. Norling LV, Sampaio ALF, Cooper D and Perretti M (2008). Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking. FASEB J vol. 22, (3) 682-690. 2007
Harrington LS, Evans RJ, Wray J, Norling L, Swales KE, Vial C, Ali F, Carrier MJ and Mitchell JA (2007). Purinergic 2X(1) receptors mediate endothelial dependent vasodilation to ATP. MOL PHARMACOL vol. 72, (5) 1132-1136. Grants
Grants of specific relevance to Predictive in vitro Models
Assessing the pro-resolving and anti-arthritic properties of cannabidiol in chronic inflammationMauro Perretti and Lucy Norling
£130,358 WHRL William Harvey Research Limited (01-10-2024 - 31-03-2026)
(EPSRC CDT 2023) Next Generation Organ-on-a-Chip TechnologiesHazel Screen, Martin Knight, Thomas Iskratsch, Caroline Roney, Yi Sui, David Lee, Julia Shelton, Tsz Ho Tse, John Connelly, Adrian Biddle and Lucy Norling
£7,066,811 EPSRC Engineering and Physical Sciences Research Council (01-07-2024 - 30-09-2032)
Melancortins to control cystic fibrosis airway inflammationMauro Perretti, Charles Mein and Lucy Norling
£21,271 Italian Cystic Fibrosis Research Foundation Fondazione Italiana per la ricerca sulla Fibrosi Cistica (01-12-2023 - 30-11-2025)
Reprogramming resolution in the arthritic joint£720,853 AR-UK Versus Arthritis (01-09-2019 - 30-09-2025)
Alector Contract ResearchLucy Norling and Dianne Cooper
£83,393 Alector, Inc. (01-12-2021 - 30-11-2023)
CardiomyopathyinRAMauro Perretti and Lucy Norling
£230,741 Bristol-Myers Squibb Pharmaceuticals Ltd (01-05-2021 - 31-12-2023)