Dr Matthew Caley

Senior Lecturer in Cell Biology

Blizard Institute
Queen Mary University of London

07971 890473

m.caley@qmul.ac.uk

Research
Publications
Grants

Research

Skin, Lipids, rare diseases, screening, Extracellular Matrix, Laminin 332

Skin Models

Interests

My research focusses on the skin basement membrane and specifically laminin 332 a three-chained glycoprotein which is copiously secreted by epithelial cells. We have demonstrated an important role for laminin 332 in skin ageing, squamous cell carcinoma invasion, cholesterol transport and in skin immune regulation.
To study these diverse functions we have generated co-culture and 3D skin models including models of aged skin that have allowed us to test gene knockdowns and drug treatments.
We have also developed and validated a high throughput screen to identify compounds altering cholesterol transport within the skin.

Publications

Publications of specific relevance to Predictive <em>in vitro</em> Models

2025

Weekly Intraperitoneal Injection of Tamoxifen in an Inducible In Vivo Model of Junctional Epidermolysis Bullosa Generates Early and Advanced Disease Phenotypes
Jones EM, Garcha P, Aumailley M, O’Toole EA, Rognoni E and Caley M
Jid Innovations, Elsevier vol. 5 (2)

DOI 10.1016/j.xjidi.2024.100331

01-03-2025

2024

Targeting the Complexity of In Vitro Skin Models: A Review of Cutting-Edge Developments
Quílez C, Bebiano LB, Jones E, Maver U, Meesters L, Parzymies P, Petiot E, Rikken G, Risueño I, Zaidi H, Zidarič T, Bekeschus S, H van den Bogaard E, Caley M, Colley H, López NG, Letsiou S, Marquette C, Maver T, Pereira RF, Tobin DJ and Velasco D
Journal of Investigative Dermatology, Elsevier vol. 144 (12), 2650-2670.

DOI 10.1016/j.jid.2024.04.032

QMRO

10-08-2024

P038 Impact of cumulative low-level ozone on keratinocytes and implications for atopic eczema pathogenesis
Tawfik S, Thomas B, Caley M, Jones E, O’Shaughnessy R and O’Toole E
British Journal of Dermatology, Oxford University Press (Oup) vol. 191 (Supplement_1), i31-i32.

DOI 10.1093/bjd/ljae090.065

28-06-2024

P16 Fibroblast signalling crosstalk drives junctional epidermolysis bullosa disease progression
Khan MRA, Kirk T, Caley MP and Rognoni E
British Journal of Dermatology, Oxford University Press (Oup) vol. 190 (6), e86-e86.

DOI 10.1093/bjd/ljae105.038

17-05-2024

P10 Janus kinase inhibitors to restore skin barrier function in a mouse model of Harlequin ichthyosis
Giusto E, Jones E, Enjalbert F, Ahmed A, Caley M, Rognoni E and O’Toole E
British Journal of Dermatology, Oxford University Press (Oup) vol. 190 (6), e83-e84.

DOI 10.1093/bjd/ljae105.032

17-05-2024

O20 Dissecting junctional epidermolysis bullosa heterogeneity
Garcha P, Jones E, Ahmed AA, Aumailley M, Rognoni E and Caley M
British Journal of Dermatology, Oxford University Press (Oup) vol. 190 (6), e77-e78.

DOI 10.1093/bjd/ljae105.020

17-05-2024

O19 Improvement of a junctional epidermolysis bullosa mouse model
Jones E, Garcha P, Aumailley M, O’Toole E, Rognoni E and Caley M
British Journal of Dermatology, Oxford University Press (Oup) vol. 190 (6), e77-e77.

DOI 10.1093/bjd/ljae105.019

17-05-2024

O08 Exploring the effect of skin ageing-related basement membrane collagen loss on nuclear mechanics
Summan S, Mayes A, Gunn D, Madapura P, Gautrot J, Caley M and O’Toole E
British Journal of Dermatology, Oxford University Press (Oup) vol. 190 (6), e71-e72.

DOI 10.1093/bjd/ljae105.008

17-05-2024

Lipid Nanoparticles Efficiently Deliver the Base Editor ABE8e for COL7A1 Correction in Dystrophic Epidermolysis Bullosa Fibroblasts In Vitro
Guri-Lamce I, Alrokh Y, Graham C, Maeshima R, Rognoni E, Caley M, Łaczmański Ł, Hart SL, McGrath JA and Jacków-Malinowska J
Journal of Investigative Dermatology, Elsevier vol. 144 (10), 2314-2317.e3.

DOI 10.1016/j.jid.2024.03.027

QMRO

01-04-2024

2023

LB1754 Treatment of human palmoplantar keratoderma skin equivalents with a TRPV3 antagonist, KM-001
Caley M, Idrissi M, Braiman L, Brener E and O'Toole E
Journal of Investigative Dermatology, Elsevier vol. 143 (9)

DOI 10.1016/j.jid.2023.06.133

01-09-2023

P32 Restoring the ageing skin barrier in vitro
Garcha P, Jones E, Shelley J and Caley M
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e26-e27.

DOI 10.1093/bjd/ljad174.053

07-07-2023

O16 The novel roles of laminin α3 in epidermal barrier function and metabolism
Parzymies P, Jones EM, Mayes A, Messenger D, O’Toole E and Caley M
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e11-e11.

DOI 10.1093/bjd/ljad174.016

07-07-2023

O13 JAK inhibitors to restore skin barrier function in ARCI
Giusto E, Enjalbert F, Rognoni E, Caley M and O’Toole E
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e9-e10.

DOI 10.1093/bjd/ljad174.013

QMRO

07-07-2023

P16 How does skin ageing-related basement membrane collagen loss affect the nucleus?
Summan SK, Mayes A, Gunn D, Gautrot J, Caley M and O’Toole E
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e20-e20.

DOI 10.1093/bjd/ljad174.037

QMRO

07-07-2023

O14 Junctional epidermolysis bullosa: repairing the epidermal lipid barrier
Jones E, Marsh S, O'Shaughnessy R, Aumailley M, McGrath J, O’Toole E and Caley M
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e10-e10.

DOI 10.1093/bjd/ljad174.014

07-07-2023

Role of Enzymic Antioxidants in Mediating Oxidative Stress and Contrasting Wound Healing Capabilities in Oral Mucosal/Skin Fibroblasts and Tissues
Lohana P, Suryaprawira A, Woods EL, Dally J, Gait-Carr E, Alaidaroos NYA, Heard CM, Lee KY, Ruge F, Farrier JN, Enoch S, Caley MP, Peake MA, Davies LC, Giles PJ, Thomas DW, Stephens P and Moseley R
Antioxidants, Mdpi vol. 12 (7)

DOI 10.3390/antiox12071374

30-06-2023

RNA sequencing and lipidomics uncovers novel pathomechanisms in recessive X-linked ichthyosis
McGeoghan F, Camera E, Maiellaro M, Menon M, Huang M, Dewan P, Ziaj S, Caley MP, Donaldson M, Enright AJ and O’Toole EA
Frontiers in Molecular Biosciences, Frontiers vol. 10

DOI 10.3389/fmolb.2023.1176802

QMRO

07-06-2023

1035 Understanding dynamic immune responses within a 3D microfluidic model of human skin
Hindle S, Taggart E, Blowes L, Pennington D, Singh B, Caley M and Connelly J
Journal of Investigative Dermatology, Elsevier vol. 143 (5)

DOI 10.1016/j.jid.2023.03.1046

01-05-2023

1157 Ozone as an aggravating factor in atopic eczema
Tawfik SS, Thomas B, Jones E, Caley M, O'Shaughnessy R and O'Toole E
Journal of Investigative Dermatology, Elsevier vol. 143 (5)

DOI 10.1016/j.jid.2023.03.1170

01-05-2023

763 Novel roles of laminin α3 in epidermal homeostasis
Parzymies PJ, Jones E, Mayes A, Messenger D, O'Toole E and Caley M
Journal of Investigative Dermatology, Elsevier vol. 143 (5)

DOI 10.1016/j.jid.2023.03.772

01-05-2023

753 Repairing the epidermal skin barrier in an in vivo model of junctional epidermolysis bullosa
Jones E, Marsh S, Aumailley M, McGrath JA, O'Toole E, Rognoni E and Caley M
Journal of Investigative Dermatology, Elsevier vol. 143 (5)

DOI 10.1016/j.jid.2023.03.762

QMRO

01-05-2023

741 The effect of skin ageing-related basement membrane collagen loss on the nucleus
Summan SK, Mayes A, Gunn DA, Gautrot J, Caley M and O'Toole E
Journal of Investigative Dermatology, Elsevier vol. 143 (5), s127-s127.

DOI 10.1016/j.jid.2023.03.750

QMRO

01-05-2023

ISID1157 - Ozone as an aggravating factor in atopic eczema
Tawfik S, O'Toole E, Thomas B, Caley M, Jones E and O'Shaughnessy R
, Morressier

DOI 10.26226/m.64199a055cbd02001a87dbfc

29-04-2023

Regulation of human trophoblast gene expression by endogenous retroviruses
Frost JM, Amante SM, Okae H, Jones EM, Ashley B, Lewis RM, Cleal JK, Caley MP, Arima T, Maffucci T and Branco MR
Nature Structural & Molecular Biology, Springer Nature vol. 30 (4), 527-538.

DOI 10.1038/s41594-023-00960-6

QMRO

01-04-2023

Ichthyosis linked to sphingosine 1-phosphate lyase insufficiency is due to aberrant sphingolipid and calcium regulation
Smith CJ, Williams JL, Hall C, Casas J, Caley MP, O'Toole EA, Prasad R and Metherell LA
Journal of Lipid Research, Elsevier vol. 64 (4)

DOI 10.1016/j.jlr.2023.100351

QMRO

02-03-2023

2022

216 Understanding the Mechanisms of Epidermal Barrier Damage and Repair Using 3D Skin Equivalent Models
Dina DO, Caley MP, Raj N, O’Toole EA and Connelly J
Journal of Investigative Dermatology, Elsevier vol. 142 (12)

DOI 10.1016/j.jid.2022.09.227

QMRO

01-12-2022

191 Junctional Epidermolysis Bullosa:Repairing The Epidermal Skin Barrier
Jones E, Marsh S, O’Shaughnessy R, Aumailley M, McGrath JA, O’Toole EA and Caley MP
Journal of Investigative Dermatology, Elsevier vol. 142 (12)

DOI 10.1016/j.jid.2022.09.202

01-12-2022

144 Carbonylated proteins and Ozone in atopic eczema
Tawfik SS, Thomas B, Jones E, Caley MP, O’Shaughnessy R and O’Toole EA
Journal of Investigative Dermatology, Elsevier vol. 142 (12)

DOI 10.1016/j.jid.2022.09.154

01-12-2022

184 The role of the Laminin 332 in cholesterol transport in dry and Aged skin
Parzymies P, Jones E, Caley MP, O’Toole EA, Messenger D and Mayes A
Journal of Investigative Dermatology, Elsevier vol. 142 (12)

DOI 10.1016/j.jid.2022.09.195

01-12-2022

181 Sphingosine 1-phosphate lyase insufficiency induced ichthyosis is due to sphingolipid imbalance, increased differentiation, and aberrant intercellular junctions
Smith CJ, Williams JL, Hall C, Caley MP, O’Toole EA, Prasad R and Metherell LA
Journal of Investigative Dermatology, Elsevier vol. 142 (12)

DOI 10.1016/j.jid.2022.09.192

QMRO

01-12-2022

ESDR144 - Carbonylated proteins and Ozone in atopic eczema
Tawfik S, Thomas B, Jones E, Caley M, O'Shaughnessy R, O'Toole E and Prasad Baruah K
, Morressier

DOI 10.26226/m.62fa0093bf6ce2001924f048

26-09-2022

ESDR216 - Understanding the Mechanisms of Epidermal Barrier Damage and Repair Using 3D Skin Equivalent Models
Dina D, Caley M, Raj N, O'Toole E and Connelly J
, Morressier

DOI 10.26226/m.62fa0097f990270019026ea6

25-09-2022

ESDR184 - The role of the Laminin 332 in cholesterol transport in dry and Aged skin
Parzymies P, Jones E, Caley M, O'Toole E, Messenger D and Mayes A
, Morressier

DOI 10.26226/m.62fa009529d1b0001b31c446

23-09-2022

ESDR181 - Sphingosine 1-phosphate lyase insufficiency induced ichthyosis is due to sphingolipid imbalance, increased differentiation, and aberrant intercellular junctions.
Smith C, Williams J, Hall C, Caley M, O'Toole E, Prasad R and Metherell L
, Morressier

DOI 10.26226/m.62fa0094a32203001a2f3e54

QMRO

22-09-2022

ESDR191 - Junctional Epidermolysis Bullosa:Repairing The Epidermal Skin Barrier
Jones E, Marsh S, O'Shaughnessy R, Aumailley M, McGrath J, O'Toole E and Caley M
, Morressier

DOI 10.26226/m.62fa009529d1b0001b31c454

22-09-2022

Investigating wound healing characteristics of gingival and skin keratinocytes in organotypic cultures
Smith CJ, Parkinson EK, Yang J, Pratten J, O'Toole EA, Caley MP and Braun KM
Journal of Dentistry, Elsevier vol. 125

DOI 10.1016/j.jdent.2022.104251

QMRO

09-08-2022

2021

099 Ichthyosis associated with sphingosine 1-phosphate lyase deficiency is due to aberrant calcium and sphingolipid regulation
Smith CJ, Williams JL, Caley MP, O’Toole EA, Prasad R and Metherell LA
Journal of Investigative Dermatology vol. 141 (10), s165-s165.

DOI 10.1016/j.jid.2021.08.102

QMRO

07-10-2021

Loss of the laminin subunit alpha-3 induces cell invasion and macrophage infiltration in cutaneous squamous cell carcinoma.
Caley MP, Martins VL, Moore K, Lashari M, Nissinen L, Kähäri V-M, Alexander S, Jones E, Harwood CA, Jones J, Donaldson M, Marshall JF and O'Toole EA
Br J Dermatol vol. 184 (5), 923-934.

DOI 10.1111/bjd.19471

QMRO

01-05-2021

2020

Distinctive clinical and histological characteristics of atrophic and hypertrophic facial photoageing
Langton AK, Ayer J, Griffiths TW, Rashdan E, Naidoo K, Caley MP, Birch‐Machin MA, O'Toole EA, Watson REB and Griffiths CEM
Journal of The European Academy of Dermatology and Venereology, Wiley vol. 35 (3), 762-768.

DOI 10.1111/jdv.17063

30-12-2020

3D model of harlequin ichthyosis reveals inflammatory therapeutic targets.
Enjalbert F, Dewan P, Caley MP, Jones EM, Morse MA, Kelsell DP, Enright AJ and O'Toole EA
Journal of Clinical Investigation, American Society For Clinical Investigation

DOI 10.1172/JCI132987

QMRO

16-06-2020

2019

Junctional Epidermolysis Bullosa: Bottom Up Control Of The Skin Barrier?
Caley M and Mai Jones E
, Morressier

DOI 10.26226/m.5d4980cd8fb7e44098e72e1a

12-09-2019

A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing
Hassan S, Purdie KJ, Wang J, Harwood CA, Proby CM, Pourreyron C, Mladkova N, Nagano A, Dhayade S, Athineos D, Caley M, Mannella V, Blyth K, Inman GJ and Leigh IM
International Journal of Molecular Sciences, Mdpi vol. 20 (14)

DOI 10.3390/ijms20143428

QMRO

12-07-2019

2018

Development and Characterisation of a Human Chronic Skin Wound Cell Line—Towards an Alternative for Animal Experimentation
Caley M, Wall IB, Peake M, Kipling D, Giles P, Thomas DW and Stephens P
International Journal of Molecular Sciences, Mdpi vol. 19 (4)

DOI 10.3390/ijms19041001

27-03-2018

2016

Maternal DNA Methylation Regulates Early Trophoblast Development
Branco MR, King M, Perez-Garcia V, Bogutz AB, Caley M, Fineberg E, Lefebvre L, Cook SJ, Dean W, Hemberger M and Reik W
Developmental Cell, Elsevier vol. 36 (2), 152-163.

DOI 10.1016/j.devcel.2015.12.027

QMRO

01-01-2016

2015

Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces
Caley MP, King H, Shah N, Wang K, Rodriguez-Teja M, Gronau JH, Waxman J and Sturge J
Clinical & Experimental Metastasis, Springer Nature vol. 33 (2), 151-165.

DOI 10.1007/s10585-015-9765-7

13-11-2015

A Novel Fully Humanized 3D Skin Equivalent to Model Early Melanoma Invasion
Hill DS, Robinson NDP, Caley MP, Chen M, O'Toole EA, Armstrong JL, Przyborski S and Lovat PE
Molecular Cancer Therapeutics, American Association For Cancer Research (Aacr) vol. 14 (11), 2665-2673.

DOI 10.1158/1535-7163.mct-15-0394

01-11-2015

Cytoskeletal protein Flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression.
Kopecki Z, Yang GN, Jackson JE, Melville EL, Calley MP, Murrell DF, Darby IA, O'Toole EA, Samuel MS and Cowin AJ
Oncotarget, Impact Journals vol. 6 (34), 36426-36440.

DOI 10.18632/oncotarget.5536

QMRO

19-10-2015

Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC.
Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M, McGrath JA, Cerio R, Kivisaari A, Kähäri VM, Hodivala-Dilke K, Brennan CH, Chen M, Marshall JF and O'Toole EA
J Natl Cancer Inst vol. 108 (1)

DOI 10.1093/jnci/djv293

QMRO

16-10-2015

Metalloproteinases and Wound Healing
Caley MP, Martins VLC and O'Toole EA
Advances in Wound Care, Mary Ann Liebert vol. 4 (4), 225-234.

DOI 10.1089/wound.2014.0581

01-04-2015

2014

AGE‐modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival
Rodriguez‐Teja M, Gronau JH, Breit C, Zhang YZ, Minamidate A, Caley MP, McCarthy A, Cox TR, Erler JT, Gaughan L, Darby S, Robson C, Mauri F, Waxman J and Sturge J
The Journal of Pathology, Wiley vol. 235 (4), 581-592.

DOI 10.1002/path.4485

24-12-2014

The receptor tyrosine kinase Axl regulates cell-cell adhesion and stemness in cutaneous squamous cell carcinoma.
Cichoń MA, Szentpetery Z, Caley MP, Papadakis ES, Mackenzie IC, Brennan CH and O'Toole EA
Oncogene vol. 33 (32), 4185-4192.

DOI 10.1038/onc.2013.388

07-08-2014

Identification of a transcriptional signature for the wound healing continuum.
Peake MA, Caley M, Giles PJ, Wall I, Enoch S, Davies LC, Kipling D, Thomas DW and Stephens P
Wound Repair Regen vol. 22 (3), 399-405.

DOI 10.1111/wrr.12170

01-01-2014

2013

miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts.
Pellegrino L, Stebbing J, Braga VM, Frampton AE, Jacob J, Buluwela L, Jiao LR, Periyasamy M, Madsen CD, Caley MP, Ottaviani S, Roca-Alonso L, El-Bahrawy M, Coombes RC, Krell J and Castellano L
Nucleic Acids Res vol. 41 (10), 5400-5412.

DOI 10.1093/nar/gkt245

QMRO

01-05-2013

Matrix metalloproteinases and epidermal wound repair.
Martins VL, Caley M and O'Toole EA
Cell Tissue Res vol. 351 (2), 255-268.

DOI 10.1007/s00441-012-1410-z

01-02-2013

Endo180 modulation by bisphosphonates and diagnostic accuracy in metastatic breast cancer.
Palmieri C, Caley MP, Purshouse K, Fonseca A-V, Rodriguez-Teja M, Kogianni G, Woodley L, Odendaal J, Elliott K, Waxman J and Sturge J
Br J Cancer vol. 108 (1), 163-169.

DOI 10.1038/bjc.2012.540

QMRO

15-01-2013

Alternatives for animal wound model systems.
Stephens P, Caley M and Peake M
Methods Mol Biol vol. 1037, 177-201.

DOI 10.1007/978-1-62703-505-7_10

01-01-2013

Alternatives for animal wound model systems
Stephens P, Caley M and Peake M
Methods in Molecular Biology vol. 1037, 177-201.

DOI 10.1007/978-1-62703-505-7_10

01-01-2013

2012

Fluorescence-based experimental model to evaluate the concomitant effect of drugs on the tumour microenvironment and cancer cells.
Ramasamy K, Khatun H, Macpherson L, Caley MP, Sturge J, Mufti GJ, Schey SA and Calle Y
Br J Haematol vol. 157 (5), 564-579.

DOI 10.1111/j.1365-2141.2012.09103.x

01-06-2012

TGFβ1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis.
Caley MP, Kogianni G, Adamarek A, Gronau JH, Rodriguez-Teja M, Fonseca A-V, Mauri F, Sandison A, Rhim JS, Pchejetski D, Palmieri C, Cobb JP, Waxman J and Sturge J
J Pathol vol. 226 (5), 775-783.

DOI 10.1002/path.3958

01-04-2012

2011

Bone metastasis in prostate cancer: emerging therapeutic strategies.
Sturge J, Caley MP and Waxman J
Nat Rev Clin Oncol vol. 8 (6), 357-368.

DOI 10.1038/nrclinonc.2011.67

01-06-2011

Authors' reply: Expanding horizons in metastatic prostate cancer treatment
Sturge J, Caley MP and Waxmanin J
Nature Reviews Clinical Oncology vol. 8 (10)

DOI 10.1038/nrclinonc.2011.67-c2

01-01-2011

Bone metastasis in prostate cancer: emerging therapeutic strategies (vol 8, pg 357, 2011)
Sturge J, Caley MP and Waxman J
Nature Reviews Clinical Oncology vol. 8 (10), 568-568.

DOI 10.1038/nrclinonc.2011.127

01-01-2011

2008

Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type 1 individuals.
Mantripragada KK, Caley M, Stephens P, Jones CJ, Kluwe L, Guha A, Mautner V and Upadhyaya M
Genes Chromosomes Cancer vol. 47 (3), 238-246.

DOI 10.1002/gcc.20525

01-03-2008

Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type I individuals
Mantripragada KK, Caley M, Stephens P, Jones CJ, Kluwe L, Guha A, Mautner V and Upadhyaya M
Genes Chromosomes & Cancer vol. 47 (3), 238-246.

DOI 10.1002/gcc.20525

01-01-2008

2007

Development and characterisation of a human cell-based chronic wound bioassay
Caley M, Wall I, Kipling D, Thomas DW and Stephens P
Wound Repair and Regeneration vol. 15 (6), A133-A133.
01-01-2007

Grants

Grants of specific relevance to Predictive in vitro Models

Improving the regenerative capacity of Junctional Epidermolysis Bullosa skin by re-activating YAP/TAZ signalling.
Gernot Walko, Matthew Caley and Emanuel Rognoni
£139,962 DEBRA UK
01-04-2025 - 31-03-2029

Evaluation of long-term effect on skin homeostasis and regeneration in a RDEB mouse model using different delivery methods of LNPs encapsulating mRNA-based base editing approach
Emanuel Rognoni and Matthew Caley
£38,000 Cure EB
01-01-2025 - 31-12-2027

Epidermal differentiation barrier and metabolism The role of basement membrane proteins in skin homeostasis ostasis.
Matthew Caley and Edel O'Toole
£127,935 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2024 - 30-09-2028

Skin differentiation, barrier and metabolism: The role of the basement membrane in skin homeostasis.
Matthew Caley and Edel O'Toole
£75,600
01-10-2024 - 30-09-2028

Industrial CASE: Genotypic phenotypic and metabolic characterisation of skin sentinels
Matthew Caley
£125,091 BBSRC Biotechnology and Biological Sciences Research Council
30-09-2024 - 29-09-2028

Wound Healing Screening
Matthew Caley
£124,270 WHRL William Harvey Research Limited
01-06-2024 - 31-12-2025

Establishing a murine RDEB disease model at QMUL
Emanuel Rognoni and Matthew Caley
£39,736 Barts and the London Charity
01-05-2024 - 01-11-2025

Improving skin regeneration in JEB by targeting the integrin αvβ6
Emanuel Rognoni, John Marshall and Matthew Caley
£139,962
01-05-2024 - 30-04-2028

Dissecting The Role Of Inflammatory pathways In Epidermolysis Bullosa (EB) Pathology
Emma Chambers, Emanuel Rognoni and Matthew Caley
£139,912 DEBRA UK
01-04-2024 - 31-03-2028

Testing the in vivo efficacy of base and prime editing in primary fibroblasts and in a 3D skin model of dystrophic epidermolysis bullosa
Emanuel Rognoni and Matthew Caley
£30,000 Cure EB
01-01-2024 - 30-09-2027

Treating JEB with Recombinant Laminin 332
Matthew Caley and Emanuel Rognoni
£177,304 DEBRA International
01-01-2024 - 31-12-2025

Genotypic, Phenotypic and Metabolic Characterisation of Skin Sentinels
Matthew Caley and Simon McArthur
£75,600 Unilever UK Ltd
01-10-2023 - 30-09-2027

Dissecting EB Heterogeneity
Matthew Caley, Emanuel Rognoni and Edel O'Toole
£182,396 Barts and the London Charity
03-04-2023 - 02-04-2027

Exploring the role and therapeutic potential of dermal fibroblasts in Junctional epidermolysis bullosa
Emanuel Rognoni and Matthew Caley
£227,055
01-09-2022 - 31-12-2025

The role of inflammasome in ageing skin
Eleri Jones and Matthew Caley
£89,978 British Skin Foundation (BSF)
01-09-2022 - 31-03-2026

How does ageing related loss of basement membrane collagen regulate epidermal barrier homeostasis
Edel O'Toole, Julien Gautrot and Matthew Caley
£64,000 Unilever UK Ltd
01-10-2021 - 30-11-2025

How does ageing related loss of basement membrane collagen regulate epidermal barrier homeostasis
Edel O'Toole, Julien Gautrot and Matthew Caley
£116,803 BBSRC Biotechnology and Biological Sciences Research Council
27-09-2021 - 20-12-2025

The role of the Laminin 332-Actin-Cholesterol axis in skin conditions with altered lipid profiles
Matthew Caley and Edel O'Toole
£64,000 Unilever UK Ltd
01-10-2020 - 30-06-2025

Consortium on the skin microbiome
Matthew Caley
£16,061
14-02-2022 - 31-03-2025

Using JAK inhibitors to repair the skin barrier in severe ichthyosis
Edel O'Toole, Emanuel Rognoni and Matthew Caley
£192,684 LifeArc
01-11-2021 - 31-08-2024

Understanding the healing potential of the oral mucosa
Emanuel Rognoni, Matthew Caley and Farida Fortune Cbe
£256,896 MCSBHT Medical College of St Bartholomew's Hospital Trust
01-09-2021 - 31-03-2025

The Role Of The Laminin 332-Actin-Cholesterol Axis In Skin Conditions With Altered Lipid Profiles - BBSRC Unilever ICASE
Matthew Caley
£114,126 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2020 - 30-09-2024

Repairing the skin barrier in Juctional Epidermolysis Bullosa (JEB)
Matthew Caley and Edel O'Toole
£152,122 LifeArc
01-09-2020 - 30-11-2022

Restoring Aged Skin; From the Bottom Up
Edel O'Toole and Matthew Caley
£85,234 Medtech SuperConnector
22-10-2019 - 31-12-2020

The basement membrane and lipid biosystems in normal and diseased skin
Matthew Caley
£89,999 British Skin Foundation (BSF)
06-06-2017 - 31-07-2019