Dr Matthew Caley
Senior Lecturer in Cell Biology
Research
Skin, Lipids, rare diseases, screening, Extracellular Matrix, Laminin 332
Interests
My research focusses on the skin basement membrane and specifically laminin 332 a three-chained glycoprotein which is copiously secreted by epithelial cells. We have demonstrated an important role for laminin 332 in skin ageing, squamous cell carcinoma invasion, cholesterol transport and in skin immune regulation.To study these diverse functions we have generated co-culture and 3D skin models including models of aged skin that have allowed us to test gene knockdowns and drug treatments.
We have also developed and validated a high throughput screen to identify compounds altering cholesterol transport within the skin.
Publications

2025

Jones EM, Garcha P, Aumailley M, O’Toole EA, Rognoni E and Caley M
Jid Innovations, Elsevier vol. 5 (2)
01-03-2025
2024

Quílez C, Bebiano LB, Jones E, Maver U, Meesters L, Parzymies P, Petiot E, Rikken G, Risueño I, Zaidi H, Zidarič T, Bekeschus S, H van den Bogaard E, Caley M, Colley H, López NG, Letsiou S, Marquette C, Maver T, Pereira RF, Tobin DJ and Velasco D
Journal of Investigative Dermatology, Elsevier vol. 144 (12), 2650-2670.
10-08-2024

Tawfik S, Thomas B, Caley M, Jones E, O’Shaughnessy R and O’Toole E
British Journal of Dermatology, Oxford University Press (Oup) vol. 191 (Supplement_1), i31-i32.
28-06-2024

Khan MRA, Kirk T, Caley MP and Rognoni E
British Journal of Dermatology, Oxford University Press (Oup) vol. 190 (6), e86-e86.
17-05-2024

Giusto E, Jones E, Enjalbert F, Ahmed A, Caley M, Rognoni E and O’Toole E
British Journal of Dermatology, Oxford University Press (Oup) vol. 190 (6), e83-e84.
17-05-2024

Garcha P, Jones E, Ahmed AA, Aumailley M, Rognoni E and Caley M
British Journal of Dermatology, Oxford University Press (Oup) vol. 190 (6), e77-e78.
17-05-2024

Jones E, Garcha P, Aumailley M, O’Toole E, Rognoni E and Caley M
British Journal of Dermatology, Oxford University Press (Oup) vol. 190 (6), e77-e77.
17-05-2024

Summan S, Mayes A, Gunn D, Madapura P, Gautrot J, Caley M and O’Toole E
British Journal of Dermatology, Oxford University Press (Oup) vol. 190 (6), e71-e72.
17-05-2024

Guri-Lamce I, Alrokh Y, Graham C, Maeshima R, Rognoni E, Caley M, Łaczmański Ł, Hart SL, McGrath JA and Jacków-Malinowska J
Journal of Investigative Dermatology, Elsevier vol. 144 (10), 2314-2317.e3.
01-04-2024
2023

Caley M, Idrissi M, Braiman L, Brener E and O'Toole E
Journal of Investigative Dermatology, Elsevier vol. 143 (9)
01-09-2023

Garcha P, Jones E, Shelley J and Caley M
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e26-e27.
07-07-2023

Parzymies P, Jones EM, Mayes A, Messenger D, O’Toole E and Caley M
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e11-e11.
07-07-2023

Giusto E, Enjalbert F, Rognoni E, Caley M and O’Toole E
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e9-e10.
07-07-2023

Summan SK, Mayes A, Gunn D, Gautrot J, Caley M and O’Toole E
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e20-e20.
07-07-2023

Jones E, Marsh S, O'Shaughnessy R, Aumailley M, McGrath J, O’Toole E and Caley M
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e10-e10.
07-07-2023

Lohana P, Suryaprawira A, Woods EL, Dally J, Gait-Carr E, Alaidaroos NYA, Heard CM, Lee KY, Ruge F, Farrier JN, Enoch S, Caley MP, Peake MA, Davies LC, Giles PJ, Thomas DW, Stephens P and Moseley R
Antioxidants, Mdpi vol. 12 (7)
30-06-2023

McGeoghan F, Camera E, Maiellaro M, Menon M, Huang M, Dewan P, Ziaj S, Caley MP, Donaldson M, Enright AJ and O’Toole EA
Frontiers in Molecular Biosciences, Frontiers vol. 10
07-06-2023

Hindle S, Taggart E, Blowes L, Pennington D, Singh B, Caley M and Connelly J
Journal of Investigative Dermatology, Elsevier vol. 143 (5)
01-05-2023

Tawfik SS, Thomas B, Jones E, Caley M, O'Shaughnessy R and O'Toole E
Journal of Investigative Dermatology, Elsevier vol. 143 (5)
01-05-2023

Parzymies PJ, Jones E, Mayes A, Messenger D, O'Toole E and Caley M
Journal of Investigative Dermatology, Elsevier vol. 143 (5)
01-05-2023

Jones E, Marsh S, Aumailley M, McGrath JA, O'Toole E, Rognoni E and Caley M
Journal of Investigative Dermatology, Elsevier vol. 143 (5)
01-05-2023

Summan SK, Mayes A, Gunn DA, Gautrot J, Caley M and O'Toole E
Journal of Investigative Dermatology, Elsevier vol. 143 (5), s127-s127.
01-05-2023

Tawfik S, O'Toole E, Thomas B, Caley M, Jones E and O'Shaughnessy R
, Morressier
29-04-2023

Frost JM, Amante SM, Okae H, Jones EM, Ashley B, Lewis RM, Cleal JK, Caley MP, Arima T, Maffucci T and Branco MR
Nature Structural & Molecular Biology, Springer Nature vol. 30 (4), 527-538.
01-04-2023

Smith CJ, Williams JL, Hall C, Casas J, Caley MP, O'Toole EA, Prasad R and Metherell LA
Journal of Lipid Research, Elsevier vol. 64 (4)
02-03-2023
2022

Dina DO, Caley MP, Raj N, O’Toole EA and Connelly J
Journal of Investigative Dermatology, Elsevier vol. 142 (12)
01-12-2022

Jones E, Marsh S, O’Shaughnessy R, Aumailley M, McGrath JA, O’Toole EA and Caley MP
Journal of Investigative Dermatology, Elsevier vol. 142 (12)
01-12-2022

Tawfik SS, Thomas B, Jones E, Caley MP, O’Shaughnessy R and O’Toole EA
Journal of Investigative Dermatology, Elsevier vol. 142 (12)
01-12-2022

Parzymies P, Jones E, Caley MP, O’Toole EA, Messenger D and Mayes A
Journal of Investigative Dermatology, Elsevier vol. 142 (12)
01-12-2022

Smith CJ, Williams JL, Hall C, Caley MP, O’Toole EA, Prasad R and Metherell LA
Journal of Investigative Dermatology, Elsevier vol. 142 (12)
01-12-2022

Tawfik S, Thomas B, Jones E, Caley M, O'Shaughnessy R, O'Toole E and Prasad Baruah K
, Morressier
26-09-2022

Dina D, Caley M, Raj N, O'Toole E and Connelly J
, Morressier
25-09-2022

Parzymies P, Jones E, Caley M, O'Toole E, Messenger D and Mayes A
, Morressier
23-09-2022

Smith C, Williams J, Hall C, Caley M, O'Toole E, Prasad R and Metherell L
, Morressier
22-09-2022

Jones E, Marsh S, O'Shaughnessy R, Aumailley M, McGrath J, O'Toole E and Caley M
, Morressier
22-09-2022

Smith CJ, Parkinson EK, Yang J, Pratten J, O'Toole EA, Caley MP and Braun KM
Journal of Dentistry, Elsevier vol. 125
09-08-2022
2021

Smith CJ, Williams JL, Caley MP, O’Toole EA, Prasad R and Metherell LA
Journal of Investigative Dermatology vol. 141 (10), s165-s165.
07-10-2021

Caley MP, Martins VL, Moore K, Lashari M, Nissinen L, Kähäri V-M, Alexander S, Jones E, Harwood CA, Jones J, Donaldson M, Marshall JF and O'Toole EA
Br J Dermatol vol. 184 (5), 923-934.
01-05-2021
2020

Langton AK, Ayer J, Griffiths TW, Rashdan E, Naidoo K, Caley MP, Birch‐Machin MA, O'Toole EA, Watson REB and Griffiths CEM
Journal of The European Academy of Dermatology and Venereology, Wiley vol. 35 (3), 762-768.
30-12-2020

Enjalbert F, Dewan P, Caley MP, Jones EM, Morse MA, Kelsell DP, Enright AJ and O'Toole EA
Journal of Clinical Investigation, American Society For Clinical Investigation
16-06-2020
2019

Caley M and Mai Jones E
, Morressier
12-09-2019

Hassan S, Purdie KJ, Wang J, Harwood CA, Proby CM, Pourreyron C, Mladkova N, Nagano A, Dhayade S, Athineos D, Caley M, Mannella V, Blyth K, Inman GJ and Leigh IM
International Journal of Molecular Sciences, Mdpi vol. 20 (14)
12-07-2019
2018

Caley M, Wall IB, Peake M, Kipling D, Giles P, Thomas DW and Stephens P
International Journal of Molecular Sciences, Mdpi vol. 19 (4)
27-03-2018
2016

Branco MR, King M, Perez-Garcia V, Bogutz AB, Caley M, Fineberg E, Lefebvre L, Cook SJ, Dean W, Hemberger M and Reik W
Developmental Cell, Elsevier vol. 36 (2), 152-163.
01-01-2016
2015

Caley MP, King H, Shah N, Wang K, Rodriguez-Teja M, Gronau JH, Waxman J and Sturge J
Clinical & Experimental Metastasis, Springer Nature vol. 33 (2), 151-165.
13-11-2015

Hill DS, Robinson NDP, Caley MP, Chen M, O'Toole EA, Armstrong JL, Przyborski S and Lovat PE
Molecular Cancer Therapeutics, American Association For Cancer Research (Aacr) vol. 14 (11), 2665-2673.
01-11-2015

Kopecki Z, Yang GN, Jackson JE, Melville EL, Calley MP, Murrell DF, Darby IA, O'Toole EA, Samuel MS and Cowin AJ
Oncotarget, Impact Journals vol. 6 (34), 36426-36440.
19-10-2015

Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M, McGrath JA, Cerio R, Kivisaari A, Kähäri VM, Hodivala-Dilke K, Brennan CH, Chen M, Marshall JF and O'Toole EA
J Natl Cancer Inst vol. 108 (1)
16-10-2015

Caley MP, Martins VLC and O'Toole EA
Advances in Wound Care, Mary Ann Liebert vol. 4 (4), 225-234.
01-04-2015
2014

Rodriguez‐Teja M, Gronau JH, Breit C, Zhang YZ, Minamidate A, Caley MP, McCarthy A, Cox TR, Erler JT, Gaughan L, Darby S, Robson C, Mauri F, Waxman J and Sturge J
The Journal of Pathology, Wiley vol. 235 (4), 581-592.
24-12-2014

Cichoń MA, Szentpetery Z, Caley MP, Papadakis ES, Mackenzie IC, Brennan CH and O'Toole EA
Oncogene vol. 33 (32), 4185-4192.
07-08-2014

Peake MA, Caley M, Giles PJ, Wall I, Enoch S, Davies LC, Kipling D, Thomas DW and Stephens P
Wound Repair Regen vol. 22 (3), 399-405.
01-01-2014
2013

Pellegrino L, Stebbing J, Braga VM, Frampton AE, Jacob J, Buluwela L, Jiao LR, Periyasamy M, Madsen CD, Caley MP, Ottaviani S, Roca-Alonso L, El-Bahrawy M, Coombes RC, Krell J and Castellano L
Nucleic Acids Res vol. 41 (10), 5400-5412.
01-05-2013

Martins VL, Caley M and O'Toole EA
Cell Tissue Res vol. 351 (2), 255-268.
01-02-2013

Palmieri C, Caley MP, Purshouse K, Fonseca A-V, Rodriguez-Teja M, Kogianni G, Woodley L, Odendaal J, Elliott K, Waxman J and Sturge J
Br J Cancer vol. 108 (1), 163-169.
15-01-2013

Stephens P, Caley M and Peake M
Methods Mol Biol vol. 1037, 177-201.
01-01-2013

Stephens P, Caley M and Peake M
Methods in Molecular Biology vol. 1037, 177-201.
01-01-2013
2012

Ramasamy K, Khatun H, Macpherson L, Caley MP, Sturge J, Mufti GJ, Schey SA and Calle Y
Br J Haematol vol. 157 (5), 564-579.
01-06-2012

Caley MP, Kogianni G, Adamarek A, Gronau JH, Rodriguez-Teja M, Fonseca A-V, Mauri F, Sandison A, Rhim JS, Pchejetski D, Palmieri C, Cobb JP, Waxman J and Sturge J
J Pathol vol. 226 (5), 775-783.
01-04-2012
2011

Sturge J, Caley MP and Waxman J
Nat Rev Clin Oncol vol. 8 (6), 357-368.
01-06-2011

Sturge J, Caley MP and Waxmanin J
Nature Reviews Clinical Oncology vol. 8 (10)
01-01-2011

Sturge J, Caley MP and Waxman J
Nature Reviews Clinical Oncology vol. 8 (10), 568-568.
01-01-2011
2008

Mantripragada KK, Caley M, Stephens P, Jones CJ, Kluwe L, Guha A, Mautner V and Upadhyaya M
Genes Chromosomes Cancer vol. 47 (3), 238-246.
01-03-2008

Mantripragada KK, Caley M, Stephens P, Jones CJ, Kluwe L, Guha A, Mautner V and Upadhyaya M
Genes Chromosomes & Cancer vol. 47 (3), 238-246.
01-01-2008
2007

Caley M, Wall I, Kipling D, Thomas DW and Stephens P
Wound Repair and Regeneration vol. 15 (6), A133-A133.
01-01-2007
Grants


Emanuel Rognoni and Matthew Caley
£38,000 Cure EB
01-01-2025 - 31-12-2027

Matthew Caley and Edel O'Toole
£127,935 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2024 - 30-09-2028

Matthew Caley and Edel O'Toole
£75,600 Unilever UK Ltd
01-10-2024 - 30-09-2028

Matthew Caley
£125,091 BBSRC Biotechnology and Biological Sciences Research Council
30-09-2024 - 29-09-2028

Matthew Caley
£124,270 WHRL William Harvey Research Limited
01-06-2024 - 31-12-2025

Emanuel Rognoni and Matthew Caley
£39,736 Barts and the London Charity
01-05-2024 - 01-11-2025

Emanuel Rognoni, John Marshall and Matthew Caley
£139,962 DEBRA UK
01-05-2024 - 30-04-2028

Emma Chambers, Emanuel Rognoni and Matthew Caley
£139,912 DEBRA UK
01-04-2024 - 31-03-2028

Emanuel Rognoni and Matthew Caley
£30,000 Cure EB
01-01-2024 - 30-09-2027

Matthew Caley and Emanuel Rognoni
£177,304 DEBRA International
01-01-2024 - 31-12-2025

Matthew Caley and Simon McArthur
£75,600 Unilever UK Ltd
01-10-2023 - 30-09-2027

Matthew Caley, Emanuel Rognoni and Edel O'Toole
£182,396 Barts and the London Charity
03-04-2023 - 02-04-2027

Emanuel Rognoni and Matthew Caley
£227,055
01-09-2022 - 31-08-2025

Eleri Jones and Matthew Caley
£89,978 British Skin Foundation (BSF)
01-09-2022 - 31-03-2026

Edel O'Toole, Julien Gautrot and Matthew Caley
£64,000 Unilever UK Ltd
01-10-2021 - 30-11-2025

Edel O'Toole, Julien Gautrot and Matthew Caley
£116,803 BBSRC Biotechnology and Biological Sciences Research Council
27-09-2021 - 20-12-2025

Matthew Caley and Edel O'Toole
£64,000 Unilever UK Ltd
01-10-2020 - 30-06-2025

Edel O'Toole, Emanuel Rognoni and Matthew Caley
£192,684 LifeArc
01-11-2021 - 31-08-2024

Emanuel Rognoni, Matthew Caley and Farida Fortune Cbe
£256,896 MCSBHT Medical College of St Bartholomew's Hospital Trust
01-09-2021 - 31-03-2025

Matthew Caley
£114,126 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2020 - 30-09-2024

Matthew Caley and Edel O'Toole
£152,122 LifeArc
01-09-2020 - 30-11-2022

Edel O'Toole and Matthew Caley
£85,234 Medtech SuperConnector
22-10-2019 - 31-12-2020

Matthew Caley
£89,999 British Skin Foundation (BSF)
06-06-2017 - 31-07-2019