Dr Magdalena K Kaneva
Lecturer in Regenerative Pharmacology
The William Harvey Research Institute
Queen Mary University of London
Queen Mary University of London
Research
osteoarthritis, cartilage repair and regeneration, alpha-1-antitrypsin, pro-resolving mediators, inflammation resolution
Interests
My research focus is on harnessing the properties of endogenous pro-resolving molecules, defining their biology and cartilage reparative signatures to inform innovative therapeutic approaches for the treatment of osteoarthritis and joint pathologies. As such, I am interested in the development of in vitro models of chondrogenesis that can accurately predict the cartilage regenerative potential of drug candidates in vivo.Publications
Publications of specific relevance to Predictive in vitro Models2024
Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory ArthritisThomas BL, Montero‐Melendez T, Oggero S, Kaneva MK, Chambers D, Pinto AL, Nerviani A, Lucchesi D, Austin‐Williams S, Hussain MT, Pitzalis C, Allen B, Malcangio M, Dell'Accio F, Norling LV and Perretti M
Arthritis & Rheumatology, Wiley vol. 76 (12), 1705-1718.
16-08-2024
2022
AB0156 INTRA-ARTICULAR AGRIN PROVIDES DIRECT PAIN RELIEF IN OSTEOARTHRITIS AND CARTILAGE DEFECTSEldridge S, Barawi A, Thorup AS, Fernandez BF, Bharde S, Sikandar S, Guan Z, Kaneva M, Lydon H, Henson F, De Bari C, McCaskie A and Dell’Accio F
Annals of The Rheumatic Diseases, Elsevier vol. 81 (Suppl 1), 1208.1-121208.
23-05-2022
Neutrophil elastase and its inhibitors-overlooked players in osteoarthritis.Kaneva MK
Febs J vol. 289 (1), 113-116.
01-01-2022
2021
AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVOEldridge S, Barawi A, Wang H, Roelofs A, Kaneva M, Guan Z, Lydon H, Thomas B, Thorup AS, Fernandez BF, Caxaria S, Strachan D, Ali A, Shanmuganathan K, Pitzalis C, Whiteford J, Henson F, Mccaskie A, De Bari C and Dell’accio F
Annals of The Rheumatic Diseases vol. 80 (Suppl 1), 1052.1-101052.
19-05-2021
Alpha‐1‐antitrypsin reduces inflammation and exerts chondroprotection in arthritisKaneva MK, Muley MM, Krustev E, Reid AR, Souza PR, Dell’Accio F, McDougall JJ and Perretti M
The Faseb Journal, Wiley vol. 35 (5)
31-03-2021
Corrigendum to “Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy”Rossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F, Kaneva MK, Getting SJ, Surace E, Testa F, Simonelli F, Grieco P, Merlino F, Perretti M, D’Amico M and Di Filippo C
Mediators of Inflammation, Hindawi vol. 2021 (1)
30-03-2021
2020
Agrin induces long term osteochondral regeneration by supporting repair morphogenesisEldridge SE, Barawi A, Wang H, Roelofs AJ, Kaneva M, GUAN Z, Lydon H, Thomas B, Thorup A-S, Fernandez-Fernandez B, Caxaria S, Strachan D, Ali A, Shanmuganathan K, Pitzalis C, Whiteford J, Henson F, McCaskie AW, De Bari C and Dell'Accio F
Science Translational Medicine, American Association For The Advancement of Science vol. 12 (559)
02-09-2020
Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated chondrocytesCan VC, Locke IC, Kaneva MK, Kerrigan MJP, Merlino F, De Pascale C, Grieco P and Getting SJ
European Journal of Pharmacology, Elsevier vol. 872
28-01-2020
2017
Identification of Novel Chondroprotective Mediators in Resolving Inflammatory ExudatesKaneva MK, Greco KV, Headland SE, Montero-Melendez T, Mori P, Greenslade K, Pitzalis C, Moore A and Perretti M
The Journal of Immunology, The American Association of Immunologists vol. 198 (7), 2876-2885.
01-04-2017
2016
Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic RetinopathyRossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F, Kaneva MK, Getting SJ, Surace E, Testa F, Simonelli F, Grieco P, Merlino F, Perretti M, D’Amico M and Di Filippo C
Mediators of Inflammation, Hindawi vol. 2016 (1)
01-01-2016
2014
Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin.Greco KV, Nalesso G, Kaneva MK, Sherwood J, Iqbal AJ, Moradi-Bidhendi N, Dell'Accio F and Perretti M
Biochem Pharmacol vol. 91 (3), 348-358.
01-10-2014
Melanocortin peptides protect chondrocytes from mechanically induced cartilage injuryKaneva MK, Kerrigan MJP, Grieco P, Curley GP, Locke IC and Getting SJ
Biochemical Pharmacology, Elsevier vol. 92 (2), 336-347.
28-08-2014
Resolution of inflammation: examples of peptidergic players and pathways.Ahmed TJ, Kaneva MK, Pitzalis C, Cooper D and Perretti M
Drug Discov Today vol. 19 (8), 1166-1171.
01-08-2014
2012
Chondroprotective and anti‐inflammatory role of melanocortin peptides in TNF‐α activated human C‐20/A4 chondrocytesKaneva MK, Kerrigan MJ, Grieco P, Curley GP, Locke IC and Getting SJ
British Journal of Pharmacology, Wiley vol. 167 (1), 67-79.
03-08-2012
The phenotypic characterization of A13/BACii, a novel bovine chondrocytic cell line with differentiation potential.Qusous A, Kaneva M, Can VC, Getting SJ and Kerrigan MJP
Cells Tissues Organs vol. 196 (3), 251-261.
01-01-2012
2009
Melanocortin peptide therapy for the treatment of arthritic pathologies.Getting SJ, Kaneva M, Bhadresa Y, Renshaw D, Leoni G, Patel HB, Kerrigan MJP and Locke IC
Scientificworldjournal vol. 9, 1394-1414.
16-12-2009
2008
A role for MC3R in modulating lung inflammationGetting SJ, Riffo-Vasquez Y, Pitchford S, Kaneva M, Grieco P, Page CP, Perretti M and Spina D
Pulm Pharmacol Ther vol. 21 (6), 866-873.
01-12-2008
Grants
Repurposing Alpha-1-antitrypsin as a treatment for post-traumatic osteoarthritisMauro Perretti and Magdalena K Kaneva
£566,515 MRC Medical Research Council
01-05-2024 - 30-04-2027
rhu-pGelsolin for treatment of arthritisMauro Perretti, Magdalena K Kaneva and Shafaq Sikandar
£460,135 BioAegis Therapeutics
01-02-2023 - 30-09-2025
INBRX-101 for cartilage regeneration in osteoarthritisMagdalena K Kaneva and Mauro Perretti
£97,499 INHIBRIX
01-02-2022 - 31-01-2024