Dr Magdalena K Kaneva
Lecturer in Regenerative Pharmacology
Barts and the London School of Medicine and Dentistry
William Harvey Research Institute
William Harvey Research Institute
Research
osteoarthritis, cartilage repair and regeneration, alpha-1-antitrypsin, pro-resolving mediators, inflammation resolution
Interests
My research focus is on harnessing the properties of endogenous pro-resolving molecules, defining their biology and cartilage reparative signatures to inform innovative therapeutic approaches for the treatment of osteoarthritis and joint pathologies. As such, I am interested in the development of in vitro models of chondrogenesis that can accurately predict the cartilage regenerative potential of drug candidates in vivo.Publications
Publications of specific relevance to Predictive in vitro Models2024
Thomas BL, Montero‐Melendez T, Oggero S, Kaneva MK, Chambers D, Pinto AL, Nerviani A, Lucchesi D, Austin‐Williams S, Hussain MT, Pitzalis C, Allen B, Malcangio M, Dell'Accio F, Norling LV and Perretti M (2024). Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis. Wiley Arthritis & Rheumatology 2022
Eldridge S, Barawi A, Thorup AS, Fernandez BF, Bharde S, Sikandar S, Guan Z, Kaneva M, Lydon H, Henson F, De Bari C, McCaskie A and Dell’Accio F (2022). AB0156 INTRA-ARTICULAR AGRIN PROVIDES DIRECT PAIN RELIEF IN OSTEOARTHRITIS AND CARTILAGE DEFECTS. BMJ Annals of the Rheumatic Diseases vol. 81, (Suppl 1) 1208.1-121208. Kaneva MK (2022). Neutrophil elastase and its inhibitors-overlooked players in osteoarthritis. FEBS J vol. 289, (1) 113-116. 2021
Eldridge S, Barawi A, Wang H, Roelofs A, Kaneva M, Guan Z, Lydon H, Thomas B, Thorup AS, Fernandez BF, Caxaria S, Strachan D, Ali A, Shanmuganathan K, Pitzalis C, Whiteford J, Henson F, Mccaskie A, De Bari C and Dell’accio F (2021). AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVO. Annals of the Rheumatic Diseases vol. 80, (Suppl 1) 1052.1-101052. 
Kaneva MK, Muley MM, Krustev E, Reid AR, Souza PR, Dell’Accio F, McDougall JJ and Perretti M (2021). Alpha‐1‐antitrypsin reduces inflammation and exerts chondroprotection in arthritis. Wiley The FASEB Journal vol. 35, (5) Rossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F, Kaneva MK, Getting SJ, Surace E, Testa F, Simonelli F, Grieco P, Merlino F, Perretti M, D’Amico M and Di Filippo C (2021). Corrigendum to “Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy”. Hindawi Mediators of Inflammation vol. 2021, (1) 2020
Eldridge SE, Barawi A, Wang H, Roelofs AJ, Kaneva M, GUAN Z, Lydon H, Thomas B, Thorup A-S, Fernandez-Fernandez B, Caxaria S, Strachan D, Ali A, Shanmuganathan K, Pitzalis C, Whiteford J, Henson F, McCaskie AW, De Bari C and Dell'Accio F (2020). Agrin induces long term osteochondral regeneration by supporting repair morphogenesis. American Association for the Advancement of Science Science Translational Medicine vol. 12, (559) Can VC, Locke IC, Kaneva MK, Kerrigan MJP, Merlino F, De Pascale C, Grieco P and Getting SJ (2020). Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated chondrocytes. Elsevier European Journal of Pharmacology vol. 872, 2017
Kaneva MK, Greco KV, Headland SE, Montero-Melendez T, Mori P, Greenslade K, Pitzalis C, Moore A and Perretti M (2017). Identification of Novel Chondroprotective Mediators in Resolving Inflammatory Exudates. The American Association of Immunologists The Journal of Immunology vol. 198, (7) 2876-2885. 2016
Rossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F, Kaneva MK, Getting SJ, Surace E, Testa F, Simonelli F, Grieco P, Merlino F, Perretti M, D’Amico M and Di Filippo C (2016). Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy. Hindawi Mediators of Inflammation vol. 2016, (1) 2014
Greco KV, Nalesso G, Kaneva MK, Sherwood J, Iqbal AJ, Moradi-Bidhendi N, Dell'Accio F and Perretti M (2014). Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin. Biochem Pharmacol vol. 91, (3) 348-358. Kaneva MK, Kerrigan MJP, Grieco P, Curley GP, Locke IC and Getting SJ (2014). Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury. Elsevier Biochemical Pharmacology vol. 92, (2) 336-347. Ahmed TJ, Kaneva MK, Pitzalis C, Cooper D and Perretti M (2014). Resolution of inflammation: examples of peptidergic players and pathways. Drug Discov Today vol. 19, (8) 1166-1171. 2012
Kaneva MK, Kerrigan MJ, Grieco P, Curley GP, Locke IC and Getting SJ (2012). Chondroprotective and anti‐inflammatory role of melanocortin peptides in TNF‐α activated human C‐20/A4 chondrocytes. Wiley British Journal of Pharmacology vol. 167, (1) 67-79. Qusous A, Kaneva M, Can VC, Getting SJ and Kerrigan MJP (2012). The phenotypic characterization of A13/BACii, a novel bovine chondrocytic cell line with differentiation potential. Cells Tissues Organs vol. 196, (3) 251-261. 2009
Getting SJ, Kaneva M, Bhadresa Y, Renshaw D, Leoni G, Patel HB, Kerrigan MJP and Locke IC (2009). Melanocortin peptide therapy for the treatment of arthritic pathologies. ScientificWorldJournal vol. 9, 1394-1414. 2008
Getting SJ, Riffo-Vasquez Y, Pitchford S, Kaneva M, Grieco P, Page CP, Perretti M and Spina D (2008). A role for MC3R in modulating lung inflammation. PULM PHARMACOL THER vol. 21, (6) 866-873. Grants
Repurposing Alpha-1-antitrypsin as a treatment for post-traumatic osteoarthritisMauro Perretti and Magdalena Kaneva
£566,515 MRC Medical Research Council (01-05-2024 - 30-04-2027)
rhu-pGelsolin for treatment of arthritisMauro Perretti, Magdalena Kaneva and Shafaq Sikandar
£460,135 BioAegis Therapeutics (01-02-2023 - 31-01-2025)
INBRX-101 for cartilage regeneration in osteoarthritisMagdalena Kaneva and Mauro Perretti
£97,499 INHIBRIX (01-02-2022 - 31-01-2024)