Prof Martin Knight

Martin Knight
BEng, MSc, PhD

Professor of Mechanobiology, Dean for Research
Co-Director of the Centre for Predictive in vitro Models

School of Engineering and Materials Science
Queen Mary University of London
+44 (0)20 7882 8868
www.sems.qmul.ac.uk/m.m.knight
ORCID Google Scholar LinkedIn

Research

organ-on-a-chip, arthritis, cancer, mechanobiology, cartilage, inflammation

Underpinning Bioengineering, Cancer Models, Cardiovascular Models, Infectious Disease and Inflammation Models, Musculoskeletal Models

Interests

Prof Martin Knight is a bioengineer developing and using organ-on-a-chip technology to study human health and disease and to streamline the drug development pipeline. Much of his work examines role of mechanobiology and how this can be incorporated into in vitro models to more accurately predict in vivo behaviour. This includes work on osteoarthritis, inflammation, cardiovascular disease, cancer and kidney disease. He has secured over £12M of recent research funding, primarily in the area of organ-on-a-chip, including £7M funding for an EPSRC Centre for Doctoral Training in Next Generation Organ-on-a-chip technology. Prof Knight is the co-Director of the Queen Mary Centre for Predictive in vitro Models, and co-directed the UK Organ-on-a-chip Technologies Network. He is active in helping to shape policy around the implementation of organ-chip technology, working with industry and other key stake holders including UK Government.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2024

Nonlinear Stress‐Induced Transformations in Collagen Fibrillar Organization, Disorder and Strain Mechanisms in the Bone‐Cartilage Unit
Badar W, Inamdar SR, Fratzl P, Snow T, Terrill NJ, Knight MM and Gupta HS
Advanced Science, Wiley, e2407649-e2407649.  
11-11-2024
Air Pollution and Osteoporosis
Allen O, Knight MM and Verbruggen SW
Current Osteoporosis Reports, Springer Science and Business Media Llc 
20-09-2024
A Self‐Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer
Liu Y, Okesola BO, de la Peña DO, Li W, Lin M, Trabulo S, Tatari M, Lawlor RT, Scarpa A, Wang W, Knight M, Loessner D, Heeschen C, Mata A and Pearce OMT
Advanced Healthcare Materials, Wiley vol. 13 (17) 
22-03-2024

2023

A Novel Primary Cilium‐Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells
Verbruggen SW, Nolan J, Duffy MP, Pearce OMT, Jacobs CR and Knight MM
Advanced Science, Wiley vol. 11 (2), 2305842-2305842.  
15-11-2023
Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment
Thompson CL, Hopkins T, Bevan C, Screen HRC, Wright KT and Knight MM
Biomedical Materials, Iop Publishing vol. 18 (6) 
10-10-2023
Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK
Nolan J, Pearce OMT, Screen HRC, Knight MM and Verbruggen SW
Cancers, Mdpi vol. 15 (3) 
19-01-2023

2022

Techniques for Visualization and Quantification of Primary Cilia in Chondrocytes
Meng H, Thompson CL, Coveney CR, Wann AK and Knight MM
In Cartilage Tissue Engineering, Springer Nature 157-176.  
11-11-2022
YAP activation inhibits inflammatory signalling and cartilage breakdown associated with reduced primary cilia expression
Meng H, Fu S, Ferreira MB, Hou Y, Pearce OM, Gavara N and Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 31 (5), 600-612.  
08-11-2022
Mechanostimulation of breast myoepithelial cells induces functional changes associated with DCIS progression to invasion
Hayward M-K, Allen MD, Gomm JJ, Goulding I, Thompson CL, Knight MM, Marshall JF and Jones JL
Npj Breast Cancer, Springer Nature vol. 8 (1) 
20-09-2022
Collagen pre-strain discontinuity at the bone—Cartilage interface
Badar W, Ali H, Brooker ON, Newham E, Snow T, Terrill NJ, Tozzi G, Fratzl P, Knight MM and Gupta HS
Plos One, Public Library of Science (Plos) vol. 17 (9) 
15-09-2022
Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems
Heywood HK, Gardner L, Knight MM and Lee DA
In Vitro Models, Springer Nature, 1-8.  
31-08-2022

2021

Reversible changes in the 3D collagen fibril architecture during cyclic loading of healthy and degraded cartilage
Inamdar SR, Prévost S, Terrill NJ, Knight MM and Gupta HS
Acta Biomaterialia, Elsevier vol. 136, 314-326.  
24-11-2021
Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype
Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR and Knight MM
Cancers, Mdpi vol. 13 (12) 
10-06-2021
A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion
Malacrida B, Nichols S, Maniati E, Jones R, Delanie-Smith R, Roozitalab R, Tyler EJ, Thomas M, Boot G, Mackerodt J, Lockley M, Knight MM, Balkwill FR and Pearce OMT
Iscience, Elsevier vol. 24 (6) 
29-05-2021
Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer
Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker LSM, Pearce OMT, Knight MM and Balkwill FR
Iscience, Elsevier vol. 24 (6) 
29-05-2021
Polycystin-2 is required for chondrocyte mechanotransduction and traffics to the primary cilium in response to mechanical stimulation
Thompson C, Mcfie M, Chapple J, BEALES P and Knight M
International Journal of Molecular Sciences, Mdpi Ag 
21-04-2021
Sub-toxic levels of cobalt ions impair mechanostranduction via HDAC6-depedent primary cilia shortening.
Wu H, Wang Z, Liu S, Meng H, Shelton JC, Thompson CL, Fu S and Knight MM
Biochem Biophys Res Commun 
15-04-2021
Corrigendum: Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models
Thompson CL, Fu S, Heywood HK, Knight MM and Thorpe SD
Frontiers in Bioengineering and Biotechnology, Frontiers vol. 9 
18-02-2021
Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer
Delaine-Smith R, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones R, Lecker L, Pearce O, Knight M and Balkwill F
, Editors: Balkwill F. Biorxiv.Org 
02-02-2021
Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction
Fu S, Meng H, Inamdar S, Das B, Gupta H, Wang W, Thompson C and Knight M
, Editors: Block JA. Osteoarthritis and Cartilage, Elsevier 
01-01-2021

2020

Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models
Thompson CL, Fu S, Heywood HK, Knight MM and Thorpe SD
Frontiers in Bioengineering and Biotechnology, Frontiers Media Sa vol. 8 
10-12-2020
Solution-Processed Epitaxial Growth of Arbitrary Surface Nanopatterns on Hybrid Perovskite Monocrystalline Thin Films.
Zhang J, Guo Q, Li X, Li C, Wu K, Abrahams I, Yan H, Knight MM, Humphreys CJ and Su L
Acs Nano vol. 14 (9), 11029-11039.  
27-08-2020
Nanoscale mapping reveals functional differences in ion channels populating the membrane of primary cilia
Torres-Pérez JV, Naeem H, Thompson CL, Knight MM and Novak P
Cellular Physiology and Biochemistry vol. 54 (1), 15-26.  
10-01-2020

2019

Sub-toxic levels of Co2+ are anti-inflammatory and protect cartilage from degradation caused by IL-1β
Fu S, Meng H, Freer F, Kwon J, Shelton JC and Knight MM
Clinical Biomechanics, Elsevier vol. 79 
24-12-2019
Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model
Walker RV, Keynton JL, Grimes DT, Sreekumar V, Williams DJ, Esapa C, Wu D, Knight MM and Norris DP
Nature Communications, Springer Nature vol. 10 (1) 
06-09-2019
Proteoglycan degradation mimics static compression by altering the natural gradients in fibrillar organisation in cartilage
Inamdar SR, Barbieri E, Terrill NJ, Knight MM and Gupta HS
Acta Biomaterialia, Elsevier vol. 97, 437-450.  
30-07-2019
Transglutaminase-2 Mediates the Biomechanical Properties of the Colorectal Cancer Tissue Microenvironment that Contribute to Disease Progression
Delaine-Smith R, Wright N, Hanley C, Hanwell R, Bhome R, Bullock M, Drifka C, Eliceiri K, Thomas G, Knight M, Mirnezami A and Peake N
Cancers, Mdpi Ag 
21-05-2019
Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation
Fu S, Thompson CL, Ali A, Wang W, Chapple JP, Mitchison HM, Beales PL, Wann AKT and Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 27 (7), 1064-1074.  
25-03-2019
An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation
Harris C, THORPE SD, Rushwan S, Wang W, THOMPSON C, Peacock J, KNIGHT M, Gooptu B and Greenough A
Journal of Biomechanics, Elsevier 
22-03-2019
Oncometabolite induced primary cilia loss in pheochromocytoma
O’Toole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM, Sharp TV, Barnes MR, Srirangalingam U, Drake WM and Chapple JP
Endocrine-Related Cancer vol. 26 (1), 165-180.  
01-01-2019

2018

Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6
Rowson DT, Shelton JC, Screen HRC and Knight MM
Scientific Reports, Springer Nature vol. 8 (1) 
23-07-2018
Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages
Xu J, Nyga A, Li W, Zhang X, Gavara N, Knight MM and Shelton JC
European Cells and Materials vol. 36, 142-155.  
01-07-2018
Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling
Kenny FN, Drymoussi Z, Delaine-Smith R, Kao AP, Laly AC, Knight MM, Philpott MP and Connelly JT
Journal of Cell Science vol. 131 (10), 215780-215780.  
15-05-2018
Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression.
Xu J, Yang J, Nyga A, Ehteramyan M, Moraga A, Wu Y, Zeng L, Knight MM and Shelton JC
Acta Biomater vol. 72, 434-446.  
09-04-2018

2017

Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers.
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones RR, Montfort A, Dowe T, Gribben J, Jones JL, Kocher HM, Serody JS, Vincent BG, Connelly J, Brenton JD, Chelala C, Cutillas PR, Lockley M, Bessant C, Knight M and Balkwill FR
Cancer Discov 
01-12-2017
Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling.
Thompson CL, Plant JC, Wann AK, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP and Knight MM
Eur Cell Mater vol. 34, 128-141.  
20-09-2017
The Secret Life of Collagen: Temporal Changes in Nanoscale Fibrillar Pre-Strain and Molecular Organization During Physiological Loading of Cartilage.
Inamdar SR, Knight DP, Terrill NJ, Karunaratne A, Cacho-Nerin F, Knight MM and Gupta HS
Acs Nano 
11-08-2017
Topography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis.
Zhang J, Dalbay MT, Luo X, Vrij E, Barbieri D, Moroni L, de Bruijn JD, van Blitterswijk CA, Chapple JP, Knight MM and Yuan H
Acta Biomater vol. 57, 487-497.  
15-07-2017
Smoothened‐antagonists reverse homogentisic acid‐induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria
Gambassi S, Geminiani M, Thorpe SD, Bernardini G, Millucci L, Braconi D, Orlandini M, Thompson CL, Petricci E, Manetti F, Taddei M, Knight MM and Santucci A
Journal of Cellular Physiology, Wiley vol. 232 (11), 3103-3111.  
29-03-2017
Reduced Primary Cilia Length and Altered Arl13b Expression Are Associated with Deregulated Chondrocyte Hedgehog Signalling in Alkaptonuria
THORPE SD, Gambassi S, Thompson CL, Chandrakumar C, Santucci A and Knight MM
Journal of Cellular Physiology, John Wiley & Sons Inc. 
03-02-2017

2016

Experimental validation of a flat punch indentation methodology calibrated against unconfined compression tests for determination of soft tissue biomechanics
Delaine-Smith RM, Burney S, Balkwill FR and Knight MM
Journal of The Mechanical Behavior of Biomedical Materials, Elsevier vol. 60, 401-415.  
01-07-2016
Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion
Sliogeryte K, Botto L, Lee DA and Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 24 (5), 912-920.  
01-05-2016
Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon.
Rowson D, Knight MM and Screen HRC
J Orthop Res vol. 34 (12), 2146-2153.  
23-03-2016
IFT88 influences chondrocyte actin organization and biomechanics
KNIGHT MM, wang W, wang Z, wann A, thompson C and hassen A
Osteoarthritis and Cartilage 
01-03-2016
Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling
Thompson CL, Wiles A, Poole CA and Knight MM
Faseb Journal vol. 30 (2), 716-726.  
01-02-2016
Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration
Sliogeryte K, Thorpe SD, Wang Z, Thompson CL, Gavara N and Knight MM
Journal of Biomechanics, Elsevier vol. 49 (2), 310-317.  
25-01-2016
Physiology of urethral flow
Knight M, Buchholz N and Bourdoumis A
In Handbook of Urinary Stents: Basic Science and Clinical Applications, Jaypee Brothers Medical Publishing 219-219.  
01-01-2016

2015

Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β
Thompson CL, Patel R, Kelly T-AN, Wann AKT, Hung CT, Chapple JP and Knight MM
Arthritis Research & Therapy vol. 17 (1) 
24-12-2015
Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult.
Tan AR, VandenBerg CD, Attur M, Abramson SB, Knight MM, Bulinski JC, Ateshian GA, Cook JL and Hung CT
Arthritis Res Ther vol. 17, 361-361.  
14-12-2015
Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling
Thompson CL, Poole CA and Knight MM
The Faseb Journal, Federation of American Society of Experimental Biology vol. 100 (4), A39-A40.  
23-10-2015
FINITE ELEMENT ANALYSIS OF MECHANICAL DEFORMATION OF CHONDROCYTE TO 2D SUBSTRATE AND 3D SCAFFOLD
CHEN J, BADER DL, LEE DA and KNIGHT MM
Journal of Mechanics in Medicine and Biology, World Scientific Publishing vol. 15 (05) 
01-10-2015
Lithium chloride prevents interleukin- 1β induced cartilage degradation and loss of mechanical properties
KNIGHT MM, Thompson CL, Yasmin H, Varone A, Wiles A and Poole CA
Journal of Orthopaedic Research, Wiley: 12 Months 
01-10-2015
Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF‐1r Onto the Primary Cilium Associated With Cilia Elongation
Dalbay MT, Thorpe SD, Connelly JT, Chapple JP and Knight MM
Stem Cells, Oxford University Press (Oup) vol. 33 (6), 1952-1961.  
21-05-2015

2014

Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics
Sliogeryte K, Thorpe SD, Lee DA, Botto L and Knight MM
Scientific Reports, Springer Nature vol. 4 (1) 
04-12-2014
The rate of hypo-osmotic challenge influences regulatory volume decrease (RVD) and mechanical properties of articular chondrocytes
Wang Z, Irianto J, Kazun S, Wang W and Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 23 (2), 289-299.  
11-11-2014
89 Primary Cilia In Tenocytes From The Inter-fascicular Matrix And The Fascicular Matrix
Rowson D, Knight M and Screen H
British Journal of Sports Medicine, Bmj vol. 48 (Suppl 2), a58-a59.  
01-09-2014
The primary cilium influences interleukin-1β-induced NFκB signalling by regulating IKK activity.
Wann AKT, Chapple JP and Knight MM
Cell Signal vol. 26 (8), 1735-1742.  
01-08-2014
Quantification of chromatin condensation level by image processing.
Irianto J, Lee DA and Knight MM
Med Eng Phys vol. 36 (3), 412-417.  
01-03-2014
Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes.
Thompson CL, Chapple JP and Knight MM
Osteoarthritis Cartilage vol. 22 (3), 490-498.  
01-03-2014
Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage.
Irianto J, Ramaswamy G, Serra R and Knight MM
J Biomech vol. 47 (2), 579-582.  
22-01-2014
In vitro encrustation of a semi-permanent polymer-covered nitinol ureter stent: an artificial urine model
Shaheen T, Edirisinghe T, Gabriel M, Bourdoumis A, Buchholz N and Knight M
Urolithiasis vol. 42 (3), 203-207.  
01-01-2014

2013

Correction: Super-Resolution Imaging Strategies for Cell Biologists Using a Spinning Disk Microscope
Hosny NA, Song M, Connelly JT, Ameer-Beg S, Knight MM and Wheeler AP
Plos One, Public Library of Science (Plos) vol. 8 (12) 
30-12-2013
Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells.
McMurray RJ, Wann AKT, Thompson CL, Connelly JT and Knight MM
Sci Rep vol. 3 
18-12-2013
Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium.
Wann AK, Thompson CL, Chapple JP and Knight MM
Cilia vol. 2 (1) 
13-12-2013
Stent encrustation in feline and human artificial urine: does the low molecular weight composition account for the difference?
Shafat M, Rajakumar K, Syme H, Buchholz N and Knight MM
Urolithiasis vol. 41 (6), 481-486.  
01-11-2013
Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes.
Irianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE and Lee DA
Biophys J vol. 104 (4), 759-769.  
19-02-2013
Super-resolution imaging strategies for cell biologists using a spinning disk microscope.
Hosny NA, Song M, Connelly JT, Ameer-Beg S, Knight MM and Wheeler AP
Plos One vol. 8 (10) 
01-01-2013
Bardet-Biedl syndrome proteins control the cilia length through regulation of actin polymerization
Hernandez-Hernandez V, Pravincumar P, Diaz-Font A, May-Simera H, Jenkins D, Knight M and Beales PL
Human Molecular Genetics vol. 22 (19), 3858-3868.  
01-01-2013
Super-resolution imaging strategies for Cell Biologists using a spinning disk microscope
Hosny NA, Song M, Knight MM and Wheeler AP
Molecular Biology of The Cell vol. 24 
01-01-2013

2012

Heat shock induces rapid resorption of primary cilia
Prodromou NV, Thompson CL, Osborn DPS, Cogger KF, Ashworth R, Knight MM, Beales PL and Chapple JP
Development, The Company of Biologists vol. 139 (24), e2408-e2408.  
15-12-2012
Heat shock induces rapid resorption of primary cilia
Prodromou NV, Thompson CL, Osborn DPS, Cogger KF, Ashworth R, Knight MM, Beales PL and Chapple JP
Journal of Cell Science vol. 125 (18), 4297-4305.  
01-12-2012
Heat-shock induces rapid resorption of primary cilia
Thompson C, Prodromou N, Osborn D, Ashworth R, Knight M, Beales P and Chapple J
Cilia, Springer Nature vol. 1 (Suppl 1) 
01-11-2012
Mechanical strain disrupts primary cilia structure and modulates hedgehog signalling in adult chondrocytes
Thompson C, Chapple J and Knight M
Cilia, Springer Nature vol. 1 (Suppl 1) 
01-11-2012
Topographical regulation of primary cilia orientation and length in mesenchymal stem cells
McMurray R and Knight M
Cilia, Springer Nature vol. 1 (Suppl 1) 
01-11-2012
A role for IFT88/the primary cilium in the inflammatory response to interleukin-1
Wann A and Knight M
Cilia, Springer Nature vol. 1 (Suppl 1) 
01-11-2012
The primary cilium conducts chondrocyte mechanotransduction
Wann A, Zuo N, Haycraft C, Jensen C, Poole C, McGlashan S and Knight M
Cilia, Springer Nature vol. 1 (Suppl 1) 
01-11-2012
Bardet-Biedl syndrome proteins control cilia length through regulation of actin polymerisation
Hernandez V, Pravincumar P, Diaz-Font A, May-Simera H, Jenkins D, Knight M and Beales P
Cilia, Springer Nature vol. 1 (Suppl 1) 
01-11-2012
The Shape of the Urine Stream - From Biophysics to Diagnostics
Wheeler APS, Morad S, Buchholz N and Knight MM
Plos One vol. 7 (10) 
16-10-2012
Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment.
Chen J, Irianto J, Inamdar S, Pravincumar P, Lee DA, Bader DL and Knight MM
Biophys J vol. 103 (6), 1188-1197.  
19-09-2012
Viscoelastic Cell Mechanics and Actin Remodelling Are Dependent on the Rate of Applied Pressure
Pravincumar P, Bader DL and Knight MM
Plos One vol. 7 (9) 
11-09-2012
Primary cilia elongation in response to interleukin-1 mediates the inflammatory response
Wann AKT and Knight MM
Cellular and Molecular Life Sciences vol. 69 (17), 2967-2977.  
01-09-2012
Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: a case study.
Bonzani IC, Campbell JJ, Knight MM, Williams A, Lee DA, Bader DL and Stevens MM
J Mech Behav Biomed Mater vol. 11, 72-81.  
01-07-2012
PRESSURE RATE SENSITIVE VISCOELASTIC CELL DEFORMATION INVOLVES ACTIN REMODELLING
Pravincumar P, Bader D and Knight M
Journal of Biomechanics, Elsevier vol. 45 
01-07-2012
Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes
Wann AKT, Zuo N, Haycraft CJ, Jensen CG, Poole CA, McGlashan SR and Knight MM
Faseb Journal vol. 26 (4), 1663-1671.  
01-04-2012
Improved outcome after peripheral nerve injury in mice with increased levels of endogenous ω-3 polyunsaturated fatty acids.
Gladman SJ, Huang W, Lim S-N, Dyall SC, Boddy S, Kang JX, Knight MM, Priestley JV and Michael-Titus AT
J Neurosci vol. 32 (2), 563-571.  
11-01-2012
Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations.
Hosny NA, Lee DA and Knight MM
J Biomed Opt vol. 17 (1) 
01-01-2012
Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading
Maeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA
Biomechanics and Modeling in Mechanobiology vol. 11 (3-4), 439-447.  
01-01-2012
The Role of the Primary Cilium in Chondrocyte Response to Mechanical Loading
Wann AKT, Thompson C and Knight MM
In Mechanically Gated Channels and Their Regulation, Springer Nature 405-426.  
01-01-2012
Topographical regulation of primary cilia orientation and length in mesenchymal stem cells
McMurray R and Knight MM
Cilia vol. 1 (Suppl 1), P34-P34.  
01-01-2012
Heat-shock induces rapid resorption of primary cilia
Thompson CL, Prodromou NV, Osborn DP, Ashworth R, Knight MM, Beales PL and Chapple JP
Cilia vol. 1 (Suppl 1), P52-P52.  
01-01-2012

2011

Omega-3 fatty acids and acute neurological trauma: a perspective on clinical translation*
Gladman S, Lim S-N, Dyall S, Knight MM, Priestley JV and Michael-Titus AT
OléAgineux Corps Gras Lipides, Edp Sciences vol. 18 (6), 317-323.  
01-11-2011
E84 Can Shockwave lithotripsy remove encrustation from ureteric nitinol stents?
Gabriel CEL, Nedilko T, Paulose PA, Bach C, Buchholz N and Knight MM
European Urology Open Science, Elsevier vol. 10 (7) 
01-10-2011
E70 The influence of extracorporeal shock wave lithotripsy on tissue viability around metallic ureteral stents
Edirisinghe TY, Knight MM, Buchholz N and Bach C
European Urology Open Science, Elsevier vol. 10 (7) 
01-10-2011
E189 Does the composition of feline urine prevent calcium oxalate encrustation of urethral stents?
Shafat M, Nedilko T, Syme H, Buchholz N and Knight MM
European Urology Open Science, Elsevier vol. 10 (7), 517-518.  
01-10-2011
E75 Comparison of encrustation rates between ureteric metal stents and Double J stents
Nedilko T, Paulose PA, Buchholz N and Knight MM
European Urology Open Science, Elsevier vol. 10 (7) 
01-10-2011
Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading
Maeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA
Biomechanics and Modeling in Mechanobiology, 1-9.  
01-01-2011
Stem cell mechanobiology.
Lee DA, Knight MM, Campbell JJ and Bader DL
J Cell Biochem vol. 112 (1), 1-9.  
01-01-2011

2010

The effect of mechanical strain or hypoxia on cell death in subpopulations of rat dorsal root ganglion neurons in vitro.
Gladman SJ, Ward RE, Michael-Titus AT, Knight MM and Priestley JV
Neuroscience vol. 171 (2), 577-587.  
01-12-2010
The potential of pulsed low intensity ultrasound to stimulate chondrocytes matrix synthesis in agarose and monolayer cultures
Vaughan NM, Grainger J, Bader DL and Knight MM
Medical and Biological Engineering and Computing vol. 48 (12), 1215-1222.  
01-12-2010
Both superficial and deep zone articular chondrocyte subpopulations exhibit the crabtree effect but have different basal oxygen consumption rates
Heywood HK, Knight MM and Lee DA
Journal of Cellular Physiology vol. 223 (3), 630-639.  
01-06-2010
Cyclic loading opens hemichannels to release ATP as part of a chondrocyte mechanotransduction pathway
Garcia M and Knight MM
Journal of Orthopaedic Research vol. 28 (4), 510-515.  
01-04-2010
A compartment model to evaluate the permeability of gap junctions between tenocytes in tendon fascicles
Ye S, Maeda E, Knight M, Lee D, Bader D and Wang W
Faseb Journal vol. 24 
01-01-2010
Measuring the biomechanical properties of cartilage cells
Bader DL and Knight MM
, 106-136.  
01-01-2010
Mechanical loading modulates chondrocyte primary cilia incidence and length
McGlashan SR, Knight MM, Chowdhury TT, Joshi P, Jensen CG, Kennedy S and Poole CA
Cell Biology International vol. 34 (5), 441-446.  
01-01-2010
Contributor contact details
Archer C, Ralphs J, Säämänen A-M, Arokoski JPA, Jurvelin JS, Kiviranta I, Hinz B, Hunziker EB, Bader DL, Knight MM, Dell’accio F, Vincent TL, Aigner T, Schmitz N, Söder S, McIlwraith CW, Hangody L, Kish G, Koreny T, Hangody LR, Módis L, Brittberg M, Sato M, Andriamanalijaona R, Li H, Elisseeff JH, Trice ME, Benjamin M, Kjær M and Magnusson SP
In Regenerative Medicine and Biomaterials For The Repair of Connective Tissues, Elsevier xiii-xvii.  
01-01-2010
4 Measuring the biomechanical properties of cartilage cells
Bader DL and Knight MM
In Regenerative Medicine and Biomaterials For The Repair of Connective Tissues, Elsevier 106-136.  
01-01-2010
1P338 1J1450 Mechano-regulation of gap junction communications between tenocytes within isolated fascicles(Bioengineering,Oral Presentations,The 48th Annual Meeting of the Biophysical Society of Japan)
Maeda E, Ye S, Knight M, Wang W, Bader D and Lee D
Seibutsu Butsuri, Biophysical Society of Japan vol. 50 (supplement2) 
01-01-2010
Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation.
Wann AKT, Mistry J, Blain EJ, Michael-Titus AT and Knight MM
Arthritis Res Ther vol. 12 (6) 
01-01-2010

2009

Articular chondrocytes express connexin 43 hemichannels and P2 receptors - A putative mechanoreceptor complex involving the primary cilium?
Knight MM, Mcglashan SR, Garcia M, Jensen CG and Poole CA
Journal of Anatomy vol. 214 (2), 275-283.  
05-02-2009

2008

Biomechanical analysis of structural deformation in living cells
Bader DL and Knight MM
Medical and Biological Engineering and Computing vol. 46 (10), 951-963.  
27-08-2008
Mechanosensitive Purinergic Calcium Signalling in Articular Chondrocytes
Pingguan-Murphy B and Knight MM
In Mechanosensitive Ion Channels, Springer Nature 235-251.  
01-01-2008

2007

Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes
Campbell JJ, Blain EJ, Chowdhury TT and Knight MM
Biochemical and Biophysical Research Communications vol. 361 (2), 329-334.  
21-09-2007
Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes
KNIGHT MM, Chowdhury TT, Campbell JJ and Blain EJ
Biochemical and Biophysical Research Communications vol. 361 (21), 329-334.  
01-09-2007
An improved confocal FRAP technique for the measurement of long-term actin dynamics in individual stress fibers
Campbell JJ and Knight MM
Microscopy Research and Technique vol. 70 (12), 1034-1040.  
01-01-2007

2006

Purinergic pathway suppresses the release of NO and stimulates proteoglycan synthesis in chondrocyte/agarose constructs subjected to dynamic compression
Chowdhury TT and Knight MM
Journal of Cellular Physiology vol. 209 (3), 845-853.  
01-12-2006
Cyclic compression of chondrocytes modulates a purinergic calcium signalling pathway in a strain rate- and frequency-dependent manner
Pingguan-Murphy B, El-Azzeh M, Bader DL and Knight MM
Journal of Cellular Physiology vol. 209 (2), 389-397.  
01-11-2006
Ultrastructure of insect and spider cocoon silks
Hakimi O, Knight DP, Knight MM, Grahn MF and Vadgama P
Biomacromolecules vol. 7 (10), 2901-2908.  
01-10-2006
Mitochondrial dynamics in chondrocytes and their connection to the mechanical properties of the cytoplasm
Bomzon Z, Knight MM, Bader DL and Kimmel E
Journal of Biomechanical Engineering vol. 128 (5), 674-679.  
01-10-2006
Intracellular mechanics and mechanotransduction associated with chondrocyte deformation during pipette aspiration
Ohashi T, Hagiwara M, Bader DL and Knight MM
Biorheology vol. 43 (3-4), 201-214.  
18-08-2006
Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields
Knight MM, Bomzon Z, Kimmel E, Sharma AM, Lee DA and Bader DL
Biomech Model Mechan vol. 5 (2-3), 180-191.  
01-06-2006
Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose.
Knight MM, Toyoda T, Lee DA and Bader DL
J Biomech vol. 39 (8), 1547-1551.  
01-01-2006
Chondrocyte Deformation and Mechanotransduction in Cartilage Model Systems(International Workshop 2)
Bader DL, Lee DA and Knight MM
The Proceedings of The Bioengineering Conference Annual Meeting of Bed/Jsme, Japan Society of Mechanical Engineers vol. 2005.18, 2-3.  
01-01-2006
Probing mechanical heterogeneity in chondrocytes using passive microtheology
Bomzon Z, Knight MM, Bader DL and Kimmel E
Journal of Biomechanics, Elsevier vol. 39 
01-01-2006

2005

Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles.
Pingguan-Murphy B, Lee DA, Bader DL and Knight MM
Arch Biochem Biophys vol. 444 (1), 45-51.  
01-12-2005

2004

Confocal analysis of local and cellular strains in chondrocyte-agarose constructs subjected to mechanical shear.
Sawae Y, Shelton JC, Bader DL and Knight MM
Ann Biomed Eng vol. 32 (6), 860-870.  
01-06-2004
Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain.
Lee DA and Knight MM
Methods Mol Med vol. 100, 307-324.  
01-01-2004
Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage.
Holloway I, Kayser M, Lee DA, Bader DL, Bentley G and Knight MM
Osteoarthritis Cartilage vol. 12 (1), 17-24.  
01-01-2004
Mechanical Loading of Chondrocytes Embedded in 3D Constructs
Lee DA and Knight MM
In Cartilage and Osteoarthritis, Springer Nature 307-324.  
01-01-2004

2003

Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death.
Knight MM, Roberts SR, Lee DA and Bader DL
Am J Physiol Cell Physiol vol. 284 (4), C1083-C1089.  
01-04-2003
Confocal Analysis of Local and Cellular Strains in Chondrocyte - Agarose Constructs Subjected to Shear.
Bader DL, SHELTON JC, Knight MM and Sawae Y
J Biochemical Engineering Asme 
01-01-2003

2002

Cell and nucleus deformation in compressed chondrocyte-alginate constructs: temporal changes and calculation of cell modulus.
Knight MM, van de Breevaart Bravenboer J, Lee DA, van Osch GJVM, Weinans H and Bader DL
Biochim Biophys Acta vol. 1570 (1), 1-8.  
15-02-2002

2001

Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose.
Knight MM, Ross JM, Sherwin AF, Lee DA, Bader DL and Poole CA
Biochim Biophys Acta vol. 1526 (2), 141-146.  
03-05-2001
Temporal changes in cytoskeletal organisation within isolated chondrocytes quantified using a novel image analysis technique.
Knight MM, Idowu BD, Lee DA and Bader DL
Med Biol Eng Comput vol. 39 (3), 397-404.  
01-05-2001
Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs.
Roberts SR, Knight MM, Lee DA and Bader DL
J Appl Physiol (1985) vol. 90 (4), 1385-1391.  
01-04-2001
Compressive deformation and damage of muscle cell subpopulations in a model system.
Bouten CV, Knight MM, Lee DA and Bade DL
Ann Biomed Eng vol. 29 (2), 153-163.  
01-02-2001

2000

Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose.
Idowu BD, Knight MM, Bader DL and Lee DA
Histochem J vol. 32 (3), 165-174.  
01-03-2000
Beta transition and stress-induced phase separation in the spinning of spider dragline silk
Knight DP, KNIGHT MM and Vollrath F
International Journal of Biological Macromolecules vol. 27 (3), 205-210.  
01-01-2000
Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels.
Lee DA, Knight MM, Bolton JF, Idowu BD, Kayser MV and Bader DL
J Biomech vol. 33 (1), 81-95.  
01-01-2000

1998

Prize-winning peeks at the microscopic world
Hing K and Knight M
 
01-12-1998
Response of chondrocyte subpopulations cultured within unloaded and loaded agarose.
Lee DA, Noguchi T, Knight MM, O'Donnell L, Bentley G and Bader DL
J Orthop Res vol. 16 (6), 726-733.  
01-11-1998
The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose.
Knight MM, Lee DA and Bader DL
Biochim Biophys Acta vol. 1405 (1-3), 67-77.  
21-10-1998
Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression.
Knight MM, Ghori SA, Lee DA and Bader DL
Med Eng Phys vol. 20 (9), 684-688.  
01-01-1998

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
solid heart iconOrgan-chip Facility: A world-class in vitro models facility for the UK community, reducing the barriers to adoption to drive animal replacement
Hazel Screen, Stefaan Verbruggen, Martin Knight, Julia Shelton, Timothy Hopkins and John Connelly
£573,537 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research 
Grant Summary

07-10-2024 - 14-03-2025
solid heart iconMicro-manufacturing of tissue patterned organ-chips for accelerated deployment of new medicines
Martin Knight, Hazel Screen, Julien Gautrot, Timothy Hopkins, John Connelly, Liisa Blowes and Xavier Griffin
£1,787,725 EPSRC Engineering and Physical Sciences Research Council 
Grant Summary

01-10-2024 - 30-09-2027
solid heart iconEPSRC Centre for Doctoral Training in Next Generation Organ-on-a-Chip Technology (COaCT)
Hazel Screen, Martin Knight, Thomas Iskratsch, Caroline Roney, Yi Sui, David Lee, Julia Shelton, Zion Tse, John Connelly, Adrian Biddle and Lucy Norling
£7,066,811 EPSRC Engineering and Physical Sciences Research Council 
Grant Summary

01-07-2024 - 30-09-2032
solid heart iconDevelopment of an Organ-on-a-chip model of polycystic kidney disease using CRISPR modified human kidney cell line
Martin Knight and Cleo Bishop
£39,986 Kidney Research UK 
Grant Summary

01-12-2023 - 30-11-2025
solid heart iconEpithelial Exchange Surfaces – From organizing principles to novel culture models of the gatekeepers of the body
Martin Knight, Hazel Screen, Wen Wang, Clare Thompson and Cleo Bishop
£260,676 EPSRC - EU Scheme 
Grant Summary

01-12-2023 - 30-11-2027
bullet iconPrecision Musculoskeletal Care
John Whiteley, Costantino Pitzalis, Martin Knight, Greg Slabaugh and Xavier Griffin
£3,343,542 NIHR National Institute for Health Research
01-12-2022 - 30-11-2027
solid heart iconIncorporating physical cues in organ-chip models
Hazel Screen and Martin Knight
£20,000 Emulate Inc.
01-10-2022 - 30-09-2026
solid heart iconHuman synovium-cartilage organ-chip for personalised surgical screening
Martin Knight
£311,203 AR-UK Versus Arthritis
01-04-2022 - 30-06-2026
solid heart iconOrgan-on-a-chip Centre of Excellence
Martin Knight and Hazel Screen
£420,794 Emulate Inc.
20-08-2019 - 01-10-2029

solid heart iconProduction of a Human Growth Plate Organ-Chip Model of Skeletal Development
Martin Knight, Clare Thompson and Hazel Screen
£197,923 BBSRC Biotechnology and Biological Sciences Research Council
01-02-2023 - 31-07-2024
bullet iconHighthroughput Light Sheet Microscopy: Imaging Across Scales
Viji Draviam Sastry, Caroline Brennan, Vidya Darbari, Jose Martin Duran, Ivan Kadurin, Isabel M Palacios, Richard Pickersgill, Sarah McClelland, Tyson Sharp and Martin Knight
£386,205 MRC Medical Research Council
01-10-2022 - 31-03-2023
bullet iconCorrelating structural and proteomic techniques on cartilage
Himadri Gupta and Martin Knight
£18,515 MRC Medical Research Council
24-07-2022 - 28-02-2023
bullet iconEmulate Organs-on-Chips Centre Technician
Martin Knight, Hazel Screen and Clare Thompson
£49,584 Emulate Inc.
01-01-2021 - 31-12-2023
solid heart iconOrgan-on-a-chip model of breast cancer bone metastases
Martin Knight and Oliver Pearce
£268,711 CR-UK Cancer Research UK
01-01-2021 - 30-06-2024
solid heart iconMICA: Organ-on-a-chip models for safety testing of regenerative medicine products
Hazel Screen and Martin Knight
£473,325 MRC Medical Research Council
24-08-2020 - 24-05-2024
bullet iconEPSRC Core Equipment Call
Wen Wang, Martin Knight, Clive Parini and Isaac Abrahams
£125,000 EPSRC Engineering and Physical Sciences Research Council
13-02-2020 - 12-08-2021
bullet iconDoes the biological clock within cartilage align to diurnal patterns in activity?
David Lee, Hannah Heywood and Martin Knight
£9,954 EPSRC Engineering and Physical Sciences Research Council
01-10-2019 - 31-10-2020
bullet iconPharmaceutical modulation of cilia expression
Martin Knight
£3,000 Royal College of Surgeons
07-05-2019 - 07-11-2019
solid heart iconOrgan-on-a-chip technologies
Hazel Screen and Martin Knight
£479,339 MRC Medical Research Council
01-08-2018 - 30-09-2022
bullet iconThe effect of cobalt ions on primary cilia in bone cells
Martin Knight and Frances Freer
£2,500 Royal College of Surgeons
01-05-2018 - 01-12-2018
bullet iconMETA-DORM - Mechanobiology of METAstatic and DORMant cancer cells in bone marrow lesions
Martin Knight
£152,740 EU Commission - Horizon 2020
01-01-2018 - 29-06-2020
bullet iconCollagen Fibrillar Network in Ageing Cartilage
Himadri Gupta and Martin Knight
£374,874 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2017 - 24-07-2023
bullet iconInnovation Fund: High-throughput Library Screen
Martin Knight
£9,960 BBSRC Biotechnology and Biological Sciences Research Council
01-09-2016 - 31-08-2018
bullet iconOsteoarthritis May Be Treated as an Environmental Ciliopathy
Martin Knight
£365,598 MRC Medical Research Council
01-09-2014 - 20-03-2020