Dr Marco Pensalfini

Marco Pensalfini

Lecturer in Mechanical and Biomedical Engineering

School of Engineering and Materials Science
Queen Mary University of London
www.sems.qmul.ac.uk/staff/m.pensalfini
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Research

Bioengineering, Wound Healing, Multiscale Biomechanics, Computational Modeling, Biomaterials, Bioinspired Design

Underpinning Bioengineering, Skin Models

Interests

Computational modeling of spatial patterning in biological systems to rationalize the contribution of microstructural constituents towards cell- and tissue-scale load bearing.

Recent work focused on simulations of new tissue formation and remodeling in wound healing, as well as self-organization in cytoskeletal systems such as F-actin and intermediate filament networks.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2023

Nonaffine Mechanics of Entangled Networks Inspired by Intermediate Filaments
Pensalfini M, Golde T, Trepat X and Arroyo M
Physical Review Letters, American Physical Society (Aps) vol. 131 (5) 
04-08-2023
Mechano-biological and bio-mechanical pathways in cutaneous wound healing
Pensalfini M and Tepole AB
Plos Computational Biology, Public Library of Science (Plos) vol. 19 (3) 
09-03-2023

2020

How cosmetic tightening products modulate the biomechanics and morphology of human skin
Pensalfini M, Rotach M, Hopf R, Bielicki A, Santoprete R and Mazza E
Acta Biomaterialia, Elsevier vol. 115, 299-316.  
25-08-2020
Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds
Wietecha MS, Pensalfini M, Cangkrama M, Müller B, Jin J, Brinckmann J, Mazza E and Werner S
Nature Communications, Springer Nature vol. 11 (1) 
25-05-2020

2019

On the compressibility and poroelasticity of human and murine skin
Wahlsten A, Pensalfini M, Stracuzzi A, Restivo G, Hopf R and Mazza E
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 18 (4), 1079-1093.  
26-02-2019
Tear resistance of soft collagenous tissues
Bircher K, Zündel M, Pensalfini M, Ehret AE and Mazza E
Nature Communications, Springer Nature vol. 10 (1) 
15-02-2019

2018

Development of a Novel Human Cell-Derived Tissue-Engineered Heart Valve for Transcatheter Aortic Valve Replacement: an In Vitro and In Vivo Feasibility Study
Lintas V, Fioretta ES, Motta SE, Dijkman PE, Pensalfini M, Mazza E, Caliskan E, Rodriguez H, Lipiski M, Sauer M, Cesarovic N, Hoerstrup SP and Emmert MY
Journal of Cardiovascular Translational Research, Springer Nature vol. 11 (6), 470-482.  
13-08-2018
A novel ultra-light suction device for mechanical characterization of skin
Müller B, Elrod J, Pensalfini M, Hopf R, Distler O, Schiestl C and Mazza E
Plos One, Public Library of Science (Plos) vol. 13 (8) 
08-08-2018

2017

Location-specific mechanical response and morphology of facial soft tissues
Pensalfini M, Weickenmeier J, Rominger M, Santoprete R, Distler O and Mazza E
Journal of The Mechanical Behavior of Biomedical Materials, Elsevier vol. 78, 108-115.  
14-11-2017
The mechanical fingerprint of murine excisional wounds
Pensalfini M, Haertel E, Hopf R, Wietecha M, Werner S and Mazza E
Acta Biomaterialia, Elsevier vol. 65, 226-236.  
12-10-2017
The suture retention test, revisited and revised
Pensalfini M, Meneghello S, Lintas V, Bircher K, Ehret AE and Mazza E
Journal of The Mechanical Behavior of Biomedical Materials, Elsevier vol. 77, 711-717.  
24-08-2017

2016

Factors affecting the mechanical behavior of collagen hydrogels for skin tissue engineering
Pensalfini M, Ehret AE, Stüdeli S, Marino D, Kaech A, Reichmann E and Mazza E
Journal of The Mechanical Behavior of Biomedical Materials, Elsevier vol. 69, 85-97.  
09-12-2016
Guidelines for standardization of bioprinting: a systematic study of process parameters and their effect on bioprinted structures
Kesti M, Fisch P, Pensalfini M, Mazza E and Zenobi-Wong M
Bionanomaterials, De Gruyter vol. 17 (3-4), 193-204.  
19-05-2016

2015

Challenging the in-vivo assessment of biomechanical properties of the uterine cervix: A critical analysis of ultrasound based quasi-static procedures
Maurer MM, Badir S, Pensalfini M, Bajka M, Abitabile P, Zimmermann R and Mazza E
Journal of Biomechanics, Elsevier vol. 48 (9), 1541-1548.  
26-02-2015

2014

Evaluation of Global Load Sharing and Shear-Lag Models to Describe Mechanical Behavior in Partially Lacerated Tendons
Pensalfini M, Duenwald-Kuehl S, Kondratko-Mittnacht J, Lakes R and Vanderby R
Journal of Biomechanical Engineering, Asme International vol. 136 (9) 
15-07-2014