Research
Bioengineering, Wound Healing, Multiscale Biomechanics, Computational Modeling, Biomaterials, Bioinspired Design
Underpinning Bioengineering, Skin Models
Interests
Computational modeling of spatial patterning in biological systems to rationalize the contribution of microstructural constituents towards cell- and tissue-scale load bearing.
Recent work focused on simulations of new tissue formation and remodeling in wound healing, as well as self-organization in cytoskeletal systems such as F-actin and intermediate filament networks.
Publications
Publications of specific relevance to Predictive <em>in vitro</em> Models
2023
Nonaffine Mechanics of Entangled Networks Inspired by Intermediate FilamentsPensalfini M, Golde T, Trepat X and Arroyo M
Physical Review Letters,
American Physical Society (Aps) vol. 131 (5)
04-08-2023Mechano-biological and bio-mechanical pathways in cutaneous wound healingPensalfini M and Tepole AB
Plos Computational Biology,
Public Library of Science (Plos) vol. 19 (3)
09-03-2023 2020
How cosmetic tightening products modulate the biomechanics and morphology of human skinPensalfini M, Rotach M, Hopf R, Bielicki A, Santoprete R and Mazza E
Acta Biomaterialia,
Elsevier vol. 115, 299-316.
25-08-2020Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin woundsWietecha MS,
Pensalfini M, Cangkrama M, Müller B, Jin J, Brinckmann J, Mazza E and Werner S
Nature Communications,
Springer Nature vol. 11 (1)
25-05-2020 2019
On the compressibility and poroelasticity of human and murine skinWahlsten A,
Pensalfini M, Stracuzzi A, Restivo G, Hopf R and Mazza E
Biomechanics and Modeling in Mechanobiology,
Springer Nature vol. 18 (4), 1079-1093.
26-02-2019 Tear resistance of soft collagenous tissuesBircher K, Zündel M,
Pensalfini M, Ehret AE and Mazza E
Nature Communications,
Springer Nature vol. 10 (1)
15-02-2019 2018
Development of a Novel Human Cell-Derived Tissue-Engineered Heart Valve for Transcatheter Aortic Valve Replacement: an In Vitro and In Vivo Feasibility StudyLintas V, Fioretta ES, Motta SE, Dijkman PE,
Pensalfini M, Mazza E, Caliskan E, Rodriguez H, Lipiski M, Sauer M, Cesarovic N, Hoerstrup SP and Emmert MY
Journal of Cardiovascular Translational Research,
Springer Nature vol. 11 (6), 470-482.
13-08-2018 A novel ultra-light suction device for mechanical characterization of skinMüller B, Elrod J,
Pensalfini M, Hopf R, Distler O, Schiestl C and Mazza E
Plos One,
Public Library of Science (Plos) vol. 13 (8)
08-08-2018 2017
Location-specific mechanical response and morphology of facial soft tissuesPensalfini M, Weickenmeier J, Rominger M, Santoprete R, Distler O and Mazza E
Journal of The Mechanical Behavior of Biomedical Materials,
Elsevier vol. 78, 108-115.
14-11-2017 The mechanical fingerprint of murine excisional woundsPensalfini M, Haertel E, Hopf R, Wietecha M, Werner S and Mazza E
Acta Biomaterialia,
Elsevier vol. 65, 226-236.
12-10-2017 The suture retention test, revisited and revisedPensalfini M, Meneghello S, Lintas V, Bircher K, Ehret AE and Mazza E
Journal of The Mechanical Behavior of Biomedical Materials,
Elsevier vol. 77, 711-717.
24-08-2017 2016
Factors affecting the mechanical behavior of collagen hydrogels for skin tissue engineeringPensalfini M, Ehret AE, Stüdeli S, Marino D, Kaech A, Reichmann E and Mazza E
Journal of The Mechanical Behavior of Biomedical Materials,
Elsevier vol. 69, 85-97.
09-12-2016 Guidelines for standardization of bioprinting: a systematic study of process parameters and their effect on bioprinted structuresKesti M, Fisch P,
Pensalfini M, Mazza E and Zenobi-Wong M
Bionanomaterials,
De Gruyter vol. 17 (3-4), 193-204.
19-05-2016 2015
Challenging the in-vivo assessment of biomechanical properties of the uterine cervix: A critical analysis of ultrasound based quasi-static proceduresMaurer MM, Badir S,
Pensalfini M, Bajka M, Abitabile P, Zimmermann R and Mazza E
Journal of Biomechanics,
Elsevier vol. 48 (9), 1541-1548.
26-02-2015 2014
Evaluation of Global Load Sharing and Shear-Lag Models to Describe Mechanical Behavior in Partially Lacerated TendonsPensalfini M, Duenwald-Kuehl S, Kondratko-Mittnacht J, Lakes R and Vanderby R
Journal of Biomechanical Engineering,
Asme International vol. 136 (9)
15-07-2014
