Dr Marco Pensalfini
Lecturer in Mechanical and Biomedical Engineering
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
Bioengineering, Wound Healing, Multiscale Biomechanics, Computational Modeling, Biomaterials, Bioinspired Design
Interests
Computational modeling of spatial patterning in biological systems to rationalize the contribution of microstructural constituents towards cell- and tissue-scale load bearing. Recent work focused on simulations of new tissue formation and remodeling in wound healing, as well as self-organization in cytoskeletal systems such as F-actin and intermediate filament networks.Publications
Publications of specific relevance to Predictive in vitro Models2023
Pensalfini M, Golde T, Trepat X and Arroyo M (2023). Nonaffine Mechanics of Entangled Networks Inspired by Intermediate Filaments. American Physical Society (Aps) Physical Review Letters vol. 131, (5) 10.1103/physrevlett.131.058101Pensalfini M and Tepole AB (2023). Mechano-biological and bio-mechanical pathways in cutaneous wound healing. Public Library of Science (Plos) Plos Computational Biology vol. 19, (3) 10.1371/journal.pcbi.10109022020
Pensalfini M, Rotach M, Hopf R, Bielicki A, Santoprete R and Mazza E (2020). How cosmetic tightening products modulate the biomechanics and morphology of human skin. Elsevier Acta Biomaterialia vol. 115, 299-316. 10.1016/j.actbio.2020.08.027Wietecha MS, Pensalfini M, Cangkrama M, Müller B, Jin J, Brinckmann J, Mazza E and Werner S (2020). Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds. Springer Nature Nature Communications vol. 11, (1) 10.1038/s41467-020-16409-z2019
Wahlsten A, Pensalfini M, Stracuzzi A, Restivo G, Hopf R and Mazza E (2019). On the compressibility and poroelasticity of human and murine skin. Springer Nature Biomechanics and Modeling in Mechanobiology vol. 18, (4) 1079-1093. 10.1007/s10237-019-01129-1Bircher K, Zündel M, Pensalfini M, Ehret AE and Mazza E (2019). Tear resistance of soft collagenous tissues. Springer Nature Nature Communications vol. 10, (1) 10.1038/s41467-019-08723-y2018
Lintas V, Fioretta ES, Motta SE, Dijkman PE, Pensalfini M, Mazza E, Caliskan E, Rodriguez H, Lipiski M, Sauer M, Cesarovic N, Hoerstrup SP and Emmert MY (2018). Development of a Novel Human Cell-Derived Tissue-Engineered Heart Valve for Transcatheter Aortic Valve Replacement: an In Vitro and In Vivo Feasibility Study. Springer Nature Journal of Cardiovascular Translational Research vol. 11, (6) 470-482. 10.1007/s12265-018-9821-1Müller B, Elrod J, Pensalfini M, Hopf R, Distler O, Schiestl C and Mazza E (2018). A novel ultra-light suction device for mechanical characterization of skin. Public Library of Science (Plos) Plos One vol. 13, (8) 10.1371/journal.pone.02014402017
Pensalfini M, Weickenmeier J, Rominger M, Santoprete R, Distler O and Mazza E (2017). Location-specific mechanical response and morphology of facial soft tissues. Elsevier Journal of The Mechanical Behavior of Biomedical Materials vol. 78, 108-115. 10.1016/j.jmbbm.2017.10.021Pensalfini M, Haertel E, Hopf R, Wietecha M, Werner S and Mazza E (2017). The mechanical fingerprint of murine excisional wounds. Elsevier Acta Biomaterialia vol. 65, 226-236. 10.1016/j.actbio.2017.10.021Pensalfini M, Meneghello S, Lintas V, Bircher K, Ehret AE and Mazza E (2017). The suture retention test, revisited and revised. Elsevier Journal of The Mechanical Behavior of Biomedical Materials vol. 77, 711-717. 10.1016/j.jmbbm.2017.08.0212016
Pensalfini M, Ehret AE, Stüdeli S, Marino D, Kaech A, Reichmann E and Mazza E (2016). Factors affecting the mechanical behavior of collagen hydrogels for skin tissue engineering. Elsevier Journal of The Mechanical Behavior of Biomedical Materials vol. 69, 85-97. 10.1016/j.jmbbm.2016.12.004Kesti M, Fisch P, Pensalfini M, Mazza E and Zenobi-Wong M (2016). Guidelines for standardization of bioprinting: a systematic study of process parameters and their effect on bioprinted structures. De Gruyter Bionanomaterials vol. 17, (3-4) 193-204. 10.1515/bnm-2016-00042015
Maurer MM, Badir S, Pensalfini M, Bajka M, Abitabile P, Zimmermann R and Mazza E (2015). Challenging the in-vivo assessment of biomechanical properties of the uterine cervix: A critical analysis of ultrasound based quasi-static procedures. Elsevier Journal of Biomechanics vol. 48, (9) 1541-1548. 10.1016/j.jbiomech.2015.02.0382014
Pensalfini M, Duenwald-Kuehl S, Kondratko-Mittnacht J, Lakes R and Vanderby R (2014). Evaluation of Global Load Sharing and Shear-Lag Models to Describe Mechanical Behavior in Partially Lacerated Tendons. Asme International Journal of Biomechanical Engineering vol. 136, (9) 10.1115/1.4027714