Prof Mauro Perretti
BSc, PhDProfessor of Immunopharmacology
The William Harvey Research Institute
Queen Mary University of London
Queen Mary University of London
Research
Therapeutic Innovation, Inflammation, Arthritis, Joint disease, Fibrosis
Interests
Interest in co-culture settings that mimic the joint: macrophages, fibroblasts and chondrocytes. Keen to collaborate on bone cells.Publications
Publications of specific relevance to Predictive in vitro Models
2024
Pessolano E, Belvedere R, Bizzarro V, Franco P, De Marco I, Porta A, Tosco A, Parente L, Perretti M and Petrella A (2024). Correction: Pessolano et al. Annexin A1 May Induce Pancreatic Cancer Progression as a Key Player of Extracellular Vesicles Effects as Evidenced in the In Vitro MIA PaCa-2 Model System. Int. J. Mol. Sci. 2018, 19, 3878. MDPI International Journal of Molecular Sciences vol. 25, (17)
Almeida PRJ, Periard AM, Tana FL, Avila RE, Milhorato LB, Alcantara KMM, Resende CB, Serufo AV, Santos FR, Teixeira DC, Queiroz‐Junior CM, Fonseca TCM, Silva BLV, Costa VV, Souza RP, Perretti M, Jonassen TEN and Teixeira MM (2024). Effects of a pro‐resolving drug in COVID‐19: preclinical studies to a randomized, placebo‐controlled, phase Ib/IIa trial in hospitalized patients. Wiley British Journal of Pharmacology vol. 181, (23) 4750-4765.
Thomas BL, Montero‐Melendez T, Oggero S, Kaneva MK, Chambers D, Pinto AL, Nerviani A, Lucchesi D, Austin‐Williams S, Hussain MT, Pitzalis C, Allen B, Malcangio M, Dell'Accio F, Norling LV and Perretti M (2024). Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis. Wiley Arthritis & Rheumatology vol. 76, (12) 1705-1718.
Andriani A, Marchetti L, Rossi F, Perretti MA, Raja S and Recine U (2024). Internal Medicine Ward with Hematological Skills for the Treatment of Complications Suffered by Hematological Patients on Therapy: Experience of Villa Betania Hospital inRome. Hematology Section, Dept. of Radiological Science and Hematology, Catholic University, Rome, Italy Mediterranean Journal of Hematology and Infectious Diseases vol. 16, (1) e2024030-e2024030.
Walker ME, De Matteis R, Perretti M and Dalli J (2024). Resolvin T4 enhances macrophage cholesterol efflux to reduce vascular disease. Springer Nature Nature Communications vol. 15, (1)
Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR, Schmidt B, Dalli J, Greene ER, Gus-Brautbar Y, Piwowarski J, Mammoto T, Zurakowski D, Perretti M, Sukhatme VP, Kaipainen A, Kieran MW, Huang S and Panigrahy D (2024). Addendum: Resolvins suppress tumor growth and enhance cancer therapy. Rockefeller University Press Journal of Experimental Medicine vol. 221, (3)
2023
Vestweber D, Claesson-Welsh L, McDonald DM, Williams T, Schwartz MA, Scallan J, Gavins FNE, van Buul J, Gamble J, Vadas M, Annex BH, Messe SR, Perretti M, André H, Ferrara N, Hla T, Nourshargh S and Simons M (2023). Report from the 2023 workshop on endothelial permeability, edema and inflammation. Springer Nature Nature Cardiovascular Research vol. 2, (12) 1120-1124.
Chen J, Oggero S, Cecconello C, Dalli J, Hayat H, Hjiej Andaloussi A, Sanni S, Jonassen TE and Perretti M (2023). The Annexin-A1 mimetic RTP-026 promotes acute cardioprotection through modulation of immune cell activation. Elsevier Pharmacological Research vol. 198,
Granell R, Curtin JA, Haider S, Kitaba NT, Mathie SA, Gregory LG, Yates LL, Tutino M, Hankinson J, Perretti M, Vonk JM, Arshad HS, Cullinan P, Fontanella S, Roberts GC, Koppelman GH, Simpson A, Turner SW, Murray CS, Lloyd CM, Holloway JW and Custovic A (2023). A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing. eLife eLife vol. 12,
Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN and Perretti M (2023). Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. American Society for Clinical Investigation JCI Insight vol. 8, (3)
Chen J, Austin-Williams S, O'Riordan CE, Claria-Ribas P, Sugimoto MA, Norling LV, Thiemermann C and Perretti M (2023). Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction. Karger Publishers Journal of Innate Immunity vol. 15, (1) 548-561.
2022
Perretti M and Subramanian M (2022). Resolution pharmacology − A fresh approach to the clinical management of human inflammatory diseases. Elsevier Seminars in Immunology vol. 65,
Ward EJ, Bert S, Fanti S, Malone KM, Maughan RT, Gkantsinikoudi C, Prin F, Volpato LK, Piovezan AP, Graham GJ, Dufton NP, Perretti M, Marelli-Berg FM and Nadkarni S (2022). Placental Inflammation Leads to Abnormal Embryonic Heart Development. Wolters Kluwer Circulation vol. 147, (12) 956-972.
Garrido-Mesa J, Thomas BL, Dodd J, Spana C, Perretti M and Montero-Melendez T (2022). Pro-resolving and anti-arthritic properties of the MC1 selective agonist PL8177. Frontiers Frontiers in Immunology vol. 13,
Bert S, Nadkarni S and Perretti M (2022). Neutrophil‐T cell crosstalk and the control of the host inflammatory response. Wiley Immunological Reviews vol. 314, (1) 36-49.
Perretti M and Dalli J (2022). Resolution Pharmacology: Focus on Pro-Resolving Annexin A1 and Lipid Mediators for Therapeutic Innovation in Inflammation. Annual Reviews The Annual Review of Pharmacology and Toxicology vol. 63, (1) 449-469.
Oggero S, Cecconello C, Silva R, Zeboudj L, Sideris-Lampretsas G, Perretti M and Malcangio M (2022). Dorsal root ganglia CX3CR1 expressing monocytes/macrophages contribute to arthritis pain. Elsevier Brain Behavior and Immunity vol. 106, 289-306.
de Araújo S, de Melo Costa VR, Santos FM, de Sousa CDF, Moreira TP, Gonçalves MR, Félix FB, Queiroz-Junior CM, Campolina-Silva GH, Nogueira ML, Sugimoto MA, Bonilha CS, Perretti M, Souza DG, Costa VV and Teixeira MM (2022). Annexin A1-FPR2/ALX Signaling Axis Regulates Acute Inflammation during Chikungunya Virus Infection. MDPI Cells vol. 11, (17)
Qin CX, Norling LV, Vecchio EA, Brennan EP, May LT, Wootten D, Godson C, Perretti M and Ritchie RH (2022). Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35. Wiley British Journal of Pharmacology vol. 179, (19) 4617-4639.
Oggero S, Godec T, van Gorp R, Pinto AL, Schurgers LJ, Reutelingsperger C, Sever P, Norling LV, Perretti M and Gupta A (2022). Role of plasma extracellular vesicles in prediction of cardiovascular risk and alterations in response to statin therapy in hypertensive patients. Wolters Kluwer Journal of Hypertension vol. 40, (8) 1522-1529.
Margraf A and Perretti M (2022). Immune Cell Plasticity in Inflammation: Insights into Description and Regulation of Immune Cell Phenotypes. MDPI Cells vol. 11, (11)
Gadipudi LL, Ramavath NN, Provera A, Reutelingsperger C, Albano E, Perretti M and Sutti S (2022). Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis. Portland Press Clinical Science vol. 136, (9) 643-656.
Costa VV, Sugimoto MA, Hubner J, Bonilha CS, Queiroz-Junior CM, Gonçalves-Pereira MH, Chen J, Gobbetti T, Rodrigues GOL, Bambirra JL, Passos IB, Lopes CEM, Moreira TP, Bonjour K, Melo RC, Oliveira MA, Andrade MVM, Sousa LP, Souza DG, da Costa Santiago H, Perretti M and Teixeira MM (2022). Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease. eLife eLife vol. 11,
Hamilton A, Rizzo R, Brod S, Ono M, Perretti M, Cooper D and D'Acquisto F (2022). The immunomodulatory effects of social isolation in mice are linked to temperature control. Elsevier Brain Behavior and Immunity vol. 102, 179-194.
Ferreira TPT, Guimarães FV, Sá YAPJ, da Silva Ribeiro NB, de Arantes ACS, de Frias Carvalho V, Sousa LP, Perretti M, Martins MA and Rodrigues e Silva PM (2022). Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice. MDPI Cells vol. 11, (5)
2021
de Paula-Silva M, da Rocha GHO, Broering MF, Queiroz ML, Sandri S, Loiola RA, Oliani SM, Vieira A, Perretti M and Farsky SHP (2021). Formyl Peptide Receptors and Annexin A1: Complementary Mechanisms to Infliximab in Murine Experimental Colitis and Crohn’s Disease. Frontiers Frontiers in Immunology vol. 12,
Chen J, Norling LV, Mesa JG, Silva MDP, Burton SE, Reutelingsperger C, Perretti M and Cooper D (2021). Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 118, (38)
Maciuszek M, Ortega-Gomez A, Maas SL, Garrido-Mesa J, Ferraro B, Perretti M, Merritt A, Nicolaes GAF, Soehnlein O and Chapman TM (2021). Design, synthesis, and biological evaluation of novel pyrrolidinone small-molecule Formyl peptide receptor 2 agonists. Elsevier European Journal of Medicinal Chemistry vol. 226,
das Dores Pereira R, Rabelo RAN, Leite PG, Cramer A, Botelho AFM, Cruz JS, Régis WCB, Perretti M, Teixeira MM and Machado FS (2021). Role of formyl peptide receptor 2 (FPR2) in modulating immune response and heart inflammation in an experimental model of acute and chronic Chagas disease. Elsevier Cellular Immunology vol. 369,
Man F, Nadkarni S, Kanabar V, E-Lacerda RR, Gomes Ferreira S, Federici Canova D, Perretti M, Page CP and Riffo-Vasquez Y (2021). A peptide derived from chaperonin 60.1, IRL201104, inhibits LPS-induced acute lung inflammation. American Physiological Society American Journal of Physiology - Lung Cellular and Molecular Physiology vol. 321, (5) l803-l813.
Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS, Gonzalez-Nuñez M, Austin-Williams SN, Cooper D, Vázquez-Martínez L, Fu T, De Rossi G, Golding M, Voisin M-B, Boulanger CM, Kubota Y, Muller WA, Tooze SA, Nightingale TD, Collinson L, Perretti M, Aksoy E and Nourshargh S (2021). Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation. Elsevier Immunity vol. 54, (9) 1989-2004.e9.
Coenen DM, Heinzmann ACA, Oggero S, Albers HJ, Nagy M, Hagué P, Kuijpers MJE, Vanderwinden J-M, van der Meer AD, Perretti M, Koenen RR and Cosemans JMEM (2021). Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions. MDPI Cells vol. 10, (8)
Koenis DS, Beegun I, Jouvene CC, Aguirre GA, Souza PR, Gonzalez-Nunez M, Ly L, Pistorius K, Kocher HM, Ricketts W, Thomas G, Perretti M, Alusi G, Pfeffer P and Dalli J (2021). Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19. Circulation Research E54-E71.
Pessolano E, Belvedere R, Novizio N, Filippelli A, Perretti M, Whiteford J and Petrella A (2021). Mesoglycan connects Syndecan‐4 and VEGFR2 through Annexin A1 and formyl peptide receptors to promote angiogenesis in vitro. Wiley The FEBS Journal vol. 288, (22) 6428-6446.
de Gaetano M, Tighe C, Gahan K, Zanetti A, Chen J, Newson J, Cacace A, Marai M, Gaffney A, Brennan E, Kantharidis P, Cooper ME, Leroy X, Perretti M, Gilroy D, Godson C and Guiry PJ (2021). Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A4 Mimetics (QNX-sLXms). American Chemical Society (ACS) Journal of Medicinal Chemistry vol. 64, (13) 9193-9216.
Marques RM, Gonzalez-Nunez M, Walker ME, Gomez EA, Colas RA, Montero-Melendez T, Perretti M and Dalli J (2021). Loss of 15-lipoxygenase disrupts Treg differentiation altering their pro-resolving functions. Springer Nature Cell Death & Differentiation vol. 28, (11) 3140-3160.
Thomas B, Eldridge S, Nosrati B, Alvarez M, THORUP A-S, Nalesso G, Caxaria S, Barawi A, Nicholson J, Perretti M, Gaston-Massuet C, Pitzalis C, Maloney A, Moore A, Jupp R and Dell'Accio F (2021). WNT3A-loaded exosomes enable cartilage repair. Co-Action Publishing Journal of Extracellular Vesicles
Ito T, Shintani Y, Fields L, Shiraishi M, Podaru M, Kainuma S, Yamashita K, Kobayashi K, Perretti M, Lewis-McDougall F and Suzuki K (2021). Cell barrier function of resident peritoneal macrophages in post-operative adhesions. Springer Nature Nature Communications vol. 12, (1)
Oggero S, de Gaetano M, Marcone S, Fitzsimons S, Pinto AL, Ikramova D, Barry M, Burke D, Montero‐Melendez T, Cooper D, Burgoyne T, Belton O, Norling LV, Brennan EP, Godson C and Perretti M (2021). Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity. Wiley Journal of Extracellular Vesicles vol. 10, (6)
Kaneva MK, Muley MM, Krustev E, Reid AR, Souza PR, Dell’Accio F, McDougall JJ and Perretti M (2021). Alpha‐1‐antitrypsin reduces inflammation and exerts chondroprotection in arthritis. Wiley The FASEB Journal vol. 35, (5)
Rossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F, Kaneva MK, Getting SJ, Surace E, Testa F, Simonelli F, Grieco P, Merlino F, Perretti M, D’Amico M and Di Filippo C (2021). Corrigendum to “Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy”. Hindawi Mediators of Inflammation vol. 2021, (1)
Maciuszek M, Ortega-Gomez A, Maas SL, Perretti M, Merritt A, Soehnlein O and Chapman TM (2021). Synthesis and evaluation of novel cyclopentane urea FPR2 agonists and their potential application in the treatment of cardiovascular inflammation. Elsevier European Journal of Medicinal Chemistry vol. 214,
Davan-Wetton CSA, Pessolano E, Perretti M and Montero-Melendez T (2021). Senescence under appraisal: hopes and challenges revisited. Springer Nature Cellular and Molecular Life Sciences vol. 78, (7) 3333-3354.
2020
Novizio N, Belvedere R, Pessolano E, Tosco A, Porta A, Perretti M, Campiglia P, Filippelli A and Petrella A (2020). Annexin A1 Released in Extracellular Vesicles by Pancreatic Cancer Cells Activates Components of the Tumor Microenvironment, through Interaction with the Formyl-Peptide Receptors. MDPI Cells vol. 9, (12)
Fitzsimons S, Oggero S, Bruen R, McCarthy C, Strowitzki MJ, Mahon NG, Ryan N, Brennan EP, Barry M, Perretti M and Belton O (2020). microRNA-155 Is Decreased During Atherosclerosis Regression and Is Increased in Urinary Extracellular Vesicles During Atherosclerosis Progression. Frontiers Frontiers in Immunology vol. 11,
Belvedere R, Morretta E, Pessolano E, Novizio N, Tosco A, Porta A, Whiteford J, Perretti M, Filippelli A, Monti MC and Petrella A (2020). RETRACTED: Mesoglycan exerts its fibrinolytic effect through the activation of annexin A2. Wiley Journal of Cellular Physiology vol. 236, (7) 4926-4943.
Perretti M (2020). Switching on resolution to treat RA moves closer to reality. Springer Nature Nature Reviews Rheumatology vol. 17, (2) 73-74.
Brouwers H, Jónasdóttir HS, Kuipers ME, Kwekkeboom JC, Auger JL, Gonzalez-Torres M, López-Vicario C, Clària J, Freysdottir J, Hardardottir I, Garrido-Mesa J, Norling LV, Perretti M, Huizinga TWJ, Kloppenburg M, Toes REM, Binstadt B, Giera M and Ioan-Facsinay A (2020). Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid. The American Association of Immunologists The Journal of Immunology vol. 205, (10) 2840-2849.
Souza PR, Walker ME, Goulding NJ, Dalli J, Perretti M and Norling LV (2020). The GPR40 Agonist GW9508 Enhances Neutrophil Function to Aid Bacterial Clearance During E. coli Infections. Frontiers Media Frontiers in Immunology vol. 11, 573019-573019.
Belvedere R, Novizio N, Pessolano E, Tosco A, Eletto D, Porta A, Campiglia P, Perretti M, Filippelli A and Petrella A (2020). Heparan sulfate binds the extracellular Annexin A1 and blocks its effects on pancreatic cancer cells. Elsevier Biochemical Pharmacology vol. 182,
Perretti M and Godson C (2020). Formyl peptide receptor type 2 agonists to kick‐start resolution pharmacology. Wiley British Journal of Pharmacology vol. 177, (20) 4595-4600.
Serhan CN, Gupta SK, Perretti M, Godson C, Brennan E, Li Y, Soehnlein O, Shimizu T, Werz O, Chiurchiù V, Azzi A, Dubourdeau M, Gupta SS, Schopohl P, Hoch M, Gjorgevikj D, Khan FM, Brauer D, Tripathi A, Cesnulevicius K, Lescheid D, Schultz M, Särndahl E, Repsilber D, Kruse R, Sala A, Haeggström JZ, Levy BD, Filep JG and Wolkenhauer O (2020). The Atlas of Inflammation Resolution (AIR). Elsevier Molecular Aspects of Medicine
Hebeda CB, Sandri S, Benis CM, de Paula-Silva M, Loiola RA, Reutelingsperger C, Perretti M and Farsky SHP (2020). Annexin A1/Formyl Peptide Receptor Pathway Controls Uterine Receptivity to the Blastocyst. MDPI Cells vol. 9, (5)
Allen BL, Montague-Cardoso K, Simeoli R, Colas RA, Oggero S, Vilar B, McNaughton PA, Dalli J, Perretti M, Sher E and Malcangio M (2020). Imbalance of proresolving lipid mediators in
persistent allodynia dissociated from signs of
clinical arthritis. Lippincott, Williams & Wilkins Pain
Corsiero E, Carlotti E, Jagemann L, Perretti M, Pitzalis C and Bombardieri M (2020). H and L Chain Affinity Maturation and/or Fab N-Glycosylation Influence Immunoreactivity toward Neutrophil Extracellular Trap Antigens in Rheumatoid Arthritis Synovial B Cell Clones. The American Association of Immunologists The Journal of Immunology vol. 204, (9)
Norling LV and Perretti M (2020). Proresolving lipid mediators enhance PMN-mediated bacterial clearance. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 117, (17) 9148-9150.
Piras G, Rattazzi L, Paschalidis N, Oggero S, Berti G, Ono M, Bellia F, D'Addario C, Dell'Osso B, Pariante CM, Perretti M and D'Acquisto F (2020). Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells. Elsevier Brain Behavior and Immunity vol. 87, 689-702.
Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin MB, Vinci C, Law HL, Perretti M, Norling LV, Azevedo HS and Nissim A (2020). Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody. Frontiers Media Frontiers in Immunology vol. 11,
Montero Melendez T, Nagano A, Chelala C, Filer A, Buckley CD and Perretti M (2020). Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis. Nature Research (part of Springer Nature) Nature Communications vol. 11, (1)
McArthur S, Gobbetti T, Juban G, Desgeorges T, Theret M, Gondin J, Toller-Kawahisa JE, Reutelingsperger CP, Perretti M and Mounier R (2020). Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation. American Society for Clinical Investigation Journal of Clinical Investigation
2019
Belvedere R, Pessolano E, Porta A, Tosco A, Parente L, Petrella F, Perretti M and Petrella A (2019). Mesoglycan induces the secretion of microvesicles by keratinocytes able to activate human fibroblasts and endothelial cells: A novel mechanism in skin wound healing. Elsevier European Journal of Pharmacology vol. 869,
Machado MG, Tavares LP, Souza GVS, Queiroz‐Junior CM, Ascenção FR, Lopes ME, Garcia CC, Menezes GB, Perretti M, Russo RC, Teixeira MM and Sousa LP (2019). The Annexin A1/FPR2 pathway controls the inflammatory response and bacterial dissemination in experimental pneumococcal pneumonia. Wiley The FASEB Journal vol. 34, (2) 2749-2764.
Sinniah A, Yazid S, Bena S, Oliani SM, Perretti M and Flower RJ (2019). Endogenous Annexin-A1 Negatively Regulates Mast Cell-Mediated Allergic Reactions. Frontiers Frontiers in Pharmacology vol. 10,
Barbosa CMV, Fock RA, Hastreiter AA, Reutelingsperger C, Perretti M, Paredes-Gamero EJ and Farsky SHP (2019). Extracellular annexin-A1 promotes myeloid/granulocytic differentiation of hematopoietic stem/progenitor cells via the Ca2+/MAPK signalling transduction pathway. Springer Nature Cell Death Discovery vol. 5, (1)
Pessolano E, Belvedere R, Bizzarro V, Franco P, De Marco I, Petrella F, Porta A, Tosco A, Parente L, Perretti M and Petrella A (2019). Annexin A1 Contained in Extracellular Vesicles Promotes the Activation of Keratinocytes by Mesoglycan Effects: An Autocrine Loop Through FPRs. MDPI Cells vol. 8, (7)
Vago JP, Sugimoto MA, Lima KM, Negreiros-Lima GL, Baik N, Teixeira MM, Perretti M, Parmer RJ, Miles LA and Sousa LP (2019). Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes. Frontiers Frontiers in Immunology vol. 10,
Senchenkova EY, Ansari J, Becker F, Vital SA, Al-Yafeai Z, Sparkenbaugh EM, Pawlinski R, Stokes KY, Carroll JL, Dragoi A-M, Qin CX, Ritchie RH, Sun H, Cuellar-Saenz HH, Rubinstein MR, Han YW, Orr AW, Perretti M, Granger DN and Gavins FNE (2019). Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation. Wolters Kluwer Circulation vol. 140, (4) 319-335.
Salamah MF, Ravishankar D, Vaiyapuri R, Moraes LA, Patel K, Perretti M, Gibbins JM and Vaiyapuri S (2019). The formyl peptide fMLF primes platelet activation and augments thrombus formation. Elsevier Journal of Thrombosis and Haemostasis vol. 17, (7) 1120-1133.
Bizzarro V, Belvedere R, Pessolano E, Parente L, Petrella F, Perretti M and Petrella A (2019). Mesoglycan induces keratinocyte activation by triggering syndecan‐4 pathway and the formation of the annexin A1/S100A11 complex. Wiley Journal of Cellular Physiology vol. 234, (11) 20174-20192.
Nadkarni S, Lashin H, Hollywood J, Dasgupta B, Mason JC and Perretti M (2019). Identification of an activated neutrophil phenotype in polymyalgia rheumatica during steroid treatment: potential involvement of immune cell cross talk. Portland Press Clinical Science vol. 133, (7)
Everts-Graber J, Martin KR, Thieblemont N, Mocek J, Roccabianca A, Chafey P, Le Gall M, Tacnet-Delorme P, Reutelingsperger CP, Naccache J-M, Bonnotte B, Karras A, Puéchal X, Guillevin L, Terrier B, Frachet P, Perretti M, Mouthon L and Witko-Sarsat V (2019). Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance. Elsevier Kidney International vol. 96, (2) 397-408.
Sugimoto MA, Vago JP, Perretti M and Teixeira MM (2019). Mediators of the Resolution of the Inflammatory Response. Elsevier Trends in Immunology vol. 40, (3) 212-227.
Di Paola R, Fusco R, Gugliandolo E, D'Amico R, Cordaro M, Impellizzeri D, Perretti M and Cuzzocrea S (2019). Formyl peptide receptor 1 signalling promotes experimental colitis in mice. Elsevier Pharmacological Research vol. 141, 591-601.
VOISIN M, leoni G, WOODFIN A, loumagne L, PATEL N, Di Paola R, Cuzzocrea S, THIEMERMANN C, PERRETTI M and NOURSHARGH S (2019). Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury. Wiley Journal of Pathology vol. 248, (1) 88-102.
2018
Pessolano E, Belvedere R, Bizzarro V, Franco P, De Marco I, Porta A, Tosco A, Parente L, Perretti M and Petrella A (2018). Annexin A1 May Induce Pancreatic Cancer Progression as a Key Player of Extracellular Vesicles Effects as Evidenced in the In Vitro MIA PaCa-2 Model System. MDPI International Journal of Molecular Sciences vol. 19, (12)
Petri MH, Thul S, Andonova T, Lindquist-Liljeqvist M, Jin H, Skenteris N-T, Arnardottir H, Maegdefessel L, Caidahl K, Perretti M, Roy J and Bäck M (2018). Resolution of Inflammation Through the Lipoxin and ALX/FPR2 Receptor Pathway Protects Against Abdominal Aortic Aneurysms. Elsevier JACC Basic to Translational Science vol. 3, (6) 719-727.
Salamah MF, Ravishankar D, Kodji X, Moraes LA, Williams HF, Vallance TM, Albadawi DA, Vaiyapuri R, Watson K, Gibbins JM, Brain SD, Perretti M and Vaiyapuri S (2018). The endogenous antimicrobial cathelicidin LL37 induces platelet activation and augments thrombus formation. American Society of Hematology Blood Advances vol. 2, (21) 2973-2985.
de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E, Maingot C, McLoughlin A, Brennan E, Leroy X, Loscher CE, Fallon P, Perretti M, Godson C and Guiry PJ (2018). Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms). Elsevier European Journal of Medicinal Chemistry vol. 162, 80-108.
Frigerio F, Pasqualini G, Craparotta I, Marchini S, van Vliet EA, Foerch P, Vandenplas C, Leclercq K, Aronica E, Porcu L, Pistorius K, Colas RA, Hansen TV, Perretti M, Kaminski RM, Dalli J and Vezzani A (2018). n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis. Brain vol. 141, (11) 3130-3143.
Thomas BL and Perretti M (2018). Neutrophil wrap. Springer Nature Nature Nanotechnology vol. 13, (12) 1098-1099.
MCARTHUR S, GOBBETTI T, Juban G, Desgeorges T, Theret M, Gondin J, Toller-Kawahisa J, Reutelingsperger C, PERRETTI M and Mounier R (2018). Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation. Biorxiv vol. 375709, (375709) 1-1.
Patruno S, Garrido-Mesa J, Romano M, PERRETTI M and MONTERO MELENDEZ T (2018). Ligand bias and its association with pro-resolving actions of melanocortin drugs. Frontiers Media Frontiers in Pharmacology vol. 9, (919)
PITZALIS C, CORSIERO E, JAGEMANN L, PERRETTI M and BOMBARDIERI M (2018). Characterization of a synovial B cell-derived 1 recombinant monoclonal antibody 2 targeting stromal calreticulin in the rheumatoid joints. American Association of Immunologists Journal of Immunology
Qin CX, Finlayson SB, Al-Sharea A, Tate M, De Blasio MJ, Deo M, Rosli S, Prakoso D, Thomas CJ, Kiriazis H, Gould E, Yang YH, Morand EF, Perretti M, Murphy AJ, Du X-J, Gao X-M and Ritchie RH (2018). Author Correction: Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo. Springer Nature Scientific Reports vol. 8, (1)
Lashin HMS, Nadkarni S, Oggero S, Jones HR, Knight JC, Hinds CJ and Perretti M (2018). Microvesicle Subsets in Sepsis Due to Community Acquired Pneumonia Compared to Faecal Peritonitis. Shock vol. 49, (4) 393-401.
Fusco R, Di Paola R, Gugliandolo E, D'Amico R, Perretti M and Cuzzocrea S (2018). Formyl peptide receptor 1 signalling promotes experimental colitis in mice. Wiley The FASEB Journal vol. 32, (S1) 832.10-832.10.
Hebeda CB, Machado ID, Reif‐Silva I, Moreli JB, Oliani SM, Nadkarni S, Perretti M, Bevilacqua E and Farsky SHP (2018). Endogenous annexin A1 (AnxA1) modulates early‐phase gestation and offspring sex‐ratio skewing. Wiley Journal of Cellular Physiology vol. 233, (9) 6591-6603.
Rhys HI, Dell'Accio F, Pitzalis C, Moore A, Norling LV and Perretti M (2018). Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. Elsevier EBioMedicine vol. 29, 60-69.
Oggero S, Norling L and Perretti M (2018). Microvesicles in cardiovascular inflammation: markers or mediators of cardiovascular diseases? Japanese Pharmacological Society Proceedings for Annual Meeting of The Japanese Pharmacological Society vol. WCP2018,
2017
Piovezan AP and Perretti M (2017). Potential engagement of pathways of the resolution of inflammation as mechanism of action for plants on animal models. Elsevier Journal of Ethnopharmacology vol. 221, 160-161.
Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR, Schmidt B, Dalli J, Greene ER, Gus-Brautbar Y, Piwowarski J, Mammoto T, Zurakowski D, Perretti M, Sukhatme VP, Kaipainen A, Kieran MW, Huang S and Panigrahy D (2017). Resolvins suppress tumor growth and enhance cancer therapy. Rockefeller University Press Journal of Experimental Medicine vol. 215, (1) 115-140.
Qin CX, Finlayson SB, Ai-Sharea A, Tate M, De Blasio MJ, Deo M, Rosli S, Prakoso D, Thomas CJ, Kiriazis H, Gould E, Yang YH, Morand EF, Perretti M, Murphy AJ, Du X-J, Gao X-M and Ritchie RH (2017). Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo. Macmillan Publishers Limited, part of Springer Nature Sci Rep vol. 7, (1) 16615-16615.
Simeoli R, Montague K, Jones HR, Castaldi L, Chambers D, Kelleher JH, Vacca V, Pitcher T, Grist J, Al-Ahdal H, Wong L-F, Perretti M, Lai J, Mouritzen P, Heppenstall P and Malcangio M (2017). Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma. Macmillan Publishers Limited, part of Springer Nature Nat Commun vol. 8, (1) 1778-1778.
Perretti M and Montero-Melendez T (2017). Resolution in an 'over-inflamed' era. Biochemist vol. 39, (4) 4-7.
Lima KM, Vago JP, Caux TR, Negreiros-Lima GL, Sugimoto MA, Tavares LP, Arribada RG, Carmo AAF, Galvão I, Costa BRC, Soriani FM, Pinho V, Solito E, Perretti M, Teixeira MM and Sousa LP (2017). The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1. Elsevier Journal of Biological Chemistry vol. 292, (33) 13758-13773.
Gittens BR, Bodkin JV, Nourshargh S, Perretti M and Cooper D (2017). Galectin-3: A Positive Regulator of Leukocyte Recruitment in the Inflamed Microcirculation. The American Association of Immunologists The Journal of Immunology vol. 198, (11) 4458-4469.
Perretti M and Norling LV (2017). Actions of SPM in regulating host responses in arthritis. Elsevier Molecular Aspects of Medicine vol. 58, 57-64.
Piovezan AP, Batisti AP, Benevides MLACS, Turnes BL, Martins DF, Kanis L, Duarte ECW, Cavalheiro AJ, Bueno PCP, Seed MP, Norling LV, Cooper D, Headland S, Souza PRPS and Perretti M (2017). Hydroalcoholic crude extract of Casearia sylvestris Sw. reduces chronic post-ischemic pain by activation of pro-resolving pathways. Elsevier Journal of Ethnopharmacology vol. 204, 179-188.
Perretti M, Di Filippo C, D'Amico M and Dalli J (2017). Characterizing the anti-inflammatory and tissue protective actions of a novel Annexin A1 peptide. Public Library of Science PLoS One vol. 12, (4) e0175786-e0175786.
Brod S, Gobbetti T, Gittens B, Ono M, Perretti M and D’Acquisto F (2017). The impact of environmental enrichment on the murine inflammatory immune response. American Society for Clinical Investigation JCI Insight vol. 2, (7)
Kaneva MK, Greco KV, Headland SE, Montero-Melendez T, Mori P, Greenslade K, Pitzalis C, Moore A and Perretti M (2017). Identification of Novel Chondroprotective Mediators in Resolving Inflammatory Exudates. The American Association of Immunologists The Journal of Immunology vol. 198, (7) 2876-2885.
PERRETTI M, Dalli J, Colas R, Federici Canova D and Gobbetti T (2017). Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection. National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 114, (15) 3963-3968.
Petri MH, Laguna‐Fernandez A, Arnardottir H, Wheelock CE, Perretti M, Hansson GK and Bäck M (2017). Aspirin‐triggered lipoxin A4 inhibits atherosclerosis progression in apolipoprotein E−/− mice. Wiley British Journal of Pharmacology vol. 174, (22) 4043-4054.
Perretti M, Cooper D, Dalli J and Norling LV (2017). Immune resolution mechanisms in inflammatory arthritis. Nat Rev Rheumatol vol. 13, (2) 87-99.
2016
NADKARNI SA, Smith J, Mauro C, Marelli-Berg FM, Perretti M, Sferruzzi-Perri AN, Ledwozyw A, Kishore M, Haas R, Williams DJ and Farsky S (2016). Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy., Editors: Medzhitov R. National Academy of Sciences Proceedings of the National Academy of Sciences of USA
Montero-Melendez T, Forfar RAE, Cook JM, Jerman JC, Taylor DL and Perretti M (2016). Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3. Springer Nature Cellular and Molecular Life Sciences vol. 74, (7) 1335-1345.
Simeoli R, Raso GM, Pirozzi C, Lama A, Santoro A, Russo R, Montero‐Melendez T, Canani RB, Calignano A, Perretti M and Meli R (2016). An orally administered butyrate‐releasing derivative reduces neutrophil recruitment and inflammation in dextran sulphate sodium‐induced murine colitis. Wiley British Journal of Pharmacology vol. 174, (11) 1484-1496.
Arnardottir HH, Dalli J, Norling LV, Colas RA, Perretti M and Serhan CN (2016). Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. American Association of Immunologists Journal of Immunology vol. 197, (6) 2362-2368.
Madeira MFM, Queiroz-Junior CM, Montero-Melendez T, Werneck SMC, Correa JD, Soriani FM, Garlet GP, Souza DG, Teixeira MM, Silva TA and Perretti M (2016). Melanocortin agonism as a viable strategy to control alveolar bone loss induced by oral infection. Federation of American Society of Experimental Biology (FASEB) The FASEB Journal
Chen J, Kieswich J, Chiazza F, Moyes A, Gobbetti T, Purvis G, Salvatori D, Patel N, Perretti M, Hobbs A, Collino M, Yaqoob M and THIEMERMANN C (2016). IkB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD. American Society of Nephrology Journal of the American Society of Nephrology
Vital SA, Becker F, Holloway PM, Russell J, Perretti M, Granger DN and Gavins FNE (2016). Fpr2/ALX Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral Inflammation: Impact for Therapy in Cardiovascular Disease. American Heart Association Circulation
Sugimoto MA, Sousa LP, Pinho V, Perretti M and Teixeira MM (2016). Resolution of Inflammation: What Controls Its Onset? Frontiers Media Frontiers in Immunology vol. 7,
Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN and Perretti M (2016). Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. American Society for Clinical Investigation JCI Insight vol. 1, (5)
Jones HR, Robb CT, Perretti M and Rossi AG (2016). The role of neutrophils in inflammation resolution. Seminars in Immunology vol. 28, (2) 137-145.
Brancaleone V, Esposito I, Gargiulo A, Vellecco V, Asimakopoulou A, Citi V, Calderone V, Gobbetti T, Perretti M, Papapetropoulos A, Bucci M and Cirino G (2016). d‐Penicillamine modulates hydrogen sulfide (H2S) pathway through selective inhibition of cystathionine‐γ‐lyase. Wiley British Journal of Pharmacology vol. 173, (9) 1556-1565.
Machado ID, Spatti M, Hastreiter A, Santin JR, Fock RA, Gil CD, Oliani SM, Perretti M and Farsky SHP (2016). Annexin A1 Is a Physiological Modulator of Neutrophil Maturation and Recirculation Acting on the CXCR4/CXCL12 Pathway. Wiley Journal of Cellular Physiology vol. 231, (11) 2418-2427.
Vago JP, Tavares LP, Sugimoto MA, Lima GLN, Galvão I, de Caux TR, Lima KM, Ribeiro ALC, Carneiro FS, Nunes FFC, Pinho V, Perretti M, Teixeira MM and Sousa LP (2016). Proresolving Actions of Synthetic and Natural Protease Inhibitors Are Mediated by Annexin A1. The American Association of Immunologists The Journal of Immunology vol. 196, (4) 1922-1932.
Sinniah A, Yazid S, Perretti M, Solito E and Flower RJ (2016). The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil. Elsevier International Immunopharmacology vol. 32, 87-95.
Rossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F, Kaneva MK, Getting SJ, Surace E, Testa F, Simonelli F, Grieco P, Merlino F, Perretti M, D’Amico M and Di Filippo C (2016). Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy. Hindawi Mediators of Inflammation vol. 2016, (1)
2015
Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A, Dell'Accio F, Pitzalis C, Oliani SM, Jan LY and Perretti M (2015). Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. American Association for the Advancement of Science (AAAS) Science Translational Medicine vol. 7, (315)
Perretti M, Leroy X, Bland EJ and Montero-Melendez T (2015). Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation. Elsevier Trends in Pharmacological Sciences vol. 36, (11) 737-755.
Canova DF, Pavlov AM, Norling LV, Gobbetti T, Brunelleschi S, Le Fauder P, Cenac N, Sukhorukov GB and Perretti M (2015). Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response. Elsevier Journal of Controlled Release vol. 217, 284-292.
Eldridge S, Nalesso G, Ismail H, Vicente-Greco K, Kabouridis P, Ramachandran M, Niemeier A, Herz J, Pitzalis C, Perretti M and Dell'Accio F (2015). Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo. Elsevier Annals of the Rheumatic Diseases vol. 75, (6)
McArthur S, Gobbetti T, Kusters DHM, Reutelingsperger CP, Flower RJ and Perretti M (2015). Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation. The American Association of Immunologists The Journal of Immunology vol. 195, (3) 1139-1151.
Haas R, Smith J, Rocher-Ros V, Nadkarni S, Montero-Melendez T, D’Acquisto F, Bland EJ, Bombardieri M, Pitzalis C, Perretti M, Marelli-Berg FM and Mauro C (2015). Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions. Public Library of Science (PLoS) PLOS Biology vol. 13, (7)
Holloway PM, Durrenberger PF, Trutschl M, Cvek U, Cooper D, Orr AW, Perretti M, Getting SJ and Gavins FNE (2015). Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion–Induced Neutrophil Recruitment. Wolters Kluwer Arteriosclerosis Thrombosis and Vascular Biology vol. 35, (9) 1936-1944.
Kusters DHM, Chatrou ML, Willems BAG, De Saint-Hubert M, Bauwens M, van der Vorst E, Bena S, Biessen EAL, Perretti M, Schurgers LJ and Reutelingsperger CPM (2015). Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet. Public Library of Science (PLoS) PLOS ONE vol. 10, (6)
Perretti M (2015). The resolution of inflammation: New mechanisms in patho-physiology open opportunities for pharmacology. Elsevier Seminars in Immunology vol. 27, (3) 145-148.
Trentin PG, Ferreira TPT, Arantes ACS, Ciambarella BT, Cordeiro RSB, Flower RJ, Perretti M, Martins MA and Silva PMR (2015). Annexin A1 mimetic peptide controls the inflammatory and fibrotic effects of silica particles in mice. Wiley British Journal of Pharmacology vol. 172, (12) 3058-3071.
Flower RJ and Perretti M (2015). R J Flower and M Perretti. Wiley British Journal of Pharmacology vol. 172, (7) 1651-1652.
Montero-Melendez T, Gobbetti T, Cooray SN, Jonassen TE and Perretti M (2015). Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects. The American Association of Immunologists, Inc. J Immunol vol. 194, (7) 3381-3388.
Amoruso A, Fresu LG, Dalli J, Miglietta D, Bardelli C, Canova DF, Perretti M and Brunelleschi S (2015). Characterization of the anti-inflammatory properties of NCX 429, a dual-acting compound releasing nitric oxide and naproxen. Elsevier Life Sciences vol. 126, 28-36.
Fredman G, Kamaly N, Spolitu S, Milton J, Ghorpade D, Chiasson R, Kuriakose G, Perretti M, Farokzhad O and Tabas I (2015). Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice. American Association for the Advancement of Science (AAAS) Science Translational Medicine vol. 7, (275)
Leoni G, Neumann P-A, Kamaly N, Quiros M, Nishio H, Jones HR, Sumagin R, Hilgarth RS, Alam A, Fredman G, Argyris I, Rijcken E, Kusters D, Reutelingsperger C, Perretti M, Parkos CA, Farokhzad OC, Neish AS and Nusrat A (2015). Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. American Society for Clinical Investigation Journal of Clinical Investigation vol. 125, (3) 1215-1227.
Gobbetti T, Ducheix S, le Faouder P, Perez T, Riols F, Boue J, Bertrand-Michel J, Dubourdeau M, Guillou H, Perretti M, Vergnolle N and Cenac N (2015). Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor. Br J Pharmacol vol. 172, (3) 910-923.
2014
Thompson D, McArthur S, Hislop JN, Flower RJ and Perretti M (2014). Identification of a novel recycling sequence in the C-tail of FPR2/ALX receptor: association with cell protection from apoptosis. J Biol Chem vol. 289, (52) 36166-36178.
Gallo I, Rattazzi L, Piras G, Gobbetti T, Panza E, Perretti M, Dalley JW and D'Acquisto F (2014). Formyl Peptide Receptor as a Novel Therapeutic Target for Anxiety-Related Disorders. Public Library of Science (PLoS) PLOS ONE vol. 9, (12)
Gobbetti T, Coldewey SM, Chen J, McArthur S, le Faouder P, Cenac N, Flower RJ, Thiemermann C and Perretti M (2014). Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 111, (52) 18685-18690.
Petri MH, Laguna-Fernandez A, Tseng C-N, Hedin U, Perretti M and Bäck M (2014). Aspirin-triggered 15-epi-lipoxin A4 signals through FPR2/ALX in vascular smooth muscle cells and protects against intimal hyperplasia after carotid ligation. Elsevier International Journal of Cardiology vol. 179, 370-372.
Machado ID, Santin JR, Drewes CC, Gil CD, Oliani SM, Perretti M and Farsky SHP (2014). Alterations in the profile of blood neutrophil membrane receptors caused by in vivo adrenocorticotrophic hormone actions. Am J Physiol Endocrinol Metab vol. 307, (9) E754-E763.
Brancaleone V, Mitidieri E, Flower RJ, Cirino G and Perretti M (2014). Annexin A1 mediates hydrogen sulfide properties in the control of inflammation. J Pharmacol Exp Ther vol. 351, (1) 96-104.
Greco KV, Nalesso G, Kaneva MK, Sherwood J, Iqbal AJ, Moradi-Bidhendi N, Dell'Accio F and Perretti M (2014). Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin. Biochem Pharmacol vol. 91, (3) 348-358.
Montero-Melendez T and Perretti M (2014). Gapdh gene expression is modulated by inflammatory arthritis and is not suitable for qPCR normalization. Inflammation vol. 37, (4) 1059-1069.
Cash JL, Norling LV and Perretti M (2014). Resolution of inflammation: targeting GPCRs that interact with lipids and peptides. Drug Discov Today vol. 19, (8) 1186-1192.
Ahmed TJ, Kaneva MK, Pitzalis C, Cooper D and Perretti M (2014). Resolution of inflammation: examples of peptidergic players and pathways. Drug Discov Today vol. 19, (8) 1166-1171.
Montero-Melendez T, Madeira MFM, Norling LV, Alsam A, Curtis MA, da Silva TA and Perretti M (2014). Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3. Am J Pathol vol. 184, (8) 2333-2341.
Montero-Melendez T and Perretti M (2014). Connections in pharmacology: innovation serving translational medicine. Drug Discov Today vol. 19, (7) 820-823.
Headland SE, Jones HR, D'Sa ASV, Perretti M and Norling LV (2014). Cutting-edge analysis of extracellular microparticles using ImageStream(X) imaging flow cytometry. Sci Rep vol. 4,
Fu H, Kishore M, Gittens B, Wang G, Coe D, Komarowska I, Infante E, Ridley AJ, Cooper D, Perretti M and Marelli-Berg FM (2014). Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation. Nat Commun vol. 5,
Nadkarni S, Dalli J, Hollywood J, Mason JC, Dasgupta B and Perretti M (2014). Investigational analysis reveals a potential role for neutrophils in giant-cell arteritis disease progression. Circ Res vol. 114, (2) 242-248.
Dalli J, Norling LV, Montero-Melendez T, Federici Canova D, Lashin H, Pavlov AM, Sukhorukov GB, Hinds CJ and Perretti M (2014). Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. EMBO Mol Med vol. 6, (1) 27-42.
Old EA, Nadkarni S, Grist J, Gentry C, Bevan S, Kim K-W, Mogg AJ, Perretti M and Malcangio M (2014). Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain. JOURNAL OF CLINICAL INVESTIGATION vol. 124, (5) 2023-2036.
Locatelli I, Sutti S, Jindal A, Vacchiano M, Bozzola C, Reutelingsperger C, Kusters D, Bena S, Parola M, Paternostro C, Bugianesi E, McArthur S, Albano E and Perretti M (2014). Endogenous Annexin A1 Is a Novel Protective Determinant in Nonalcoholic Steatohepatitis in Mice. HEPATOLOGY vol. 60, (2) 531-544.
Burgmaier M, Schutters K, Willems B, Van der Vorst EPC, Kusters D, Chatrou M, Norling L, Biessen EAL, Cleutjens J, Perretti M, Schurgers LJ and Reutelingsperger CPM (2014). AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE-/- mice. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE vol. 18, (10) 2117-2124.
2013
Cooray SN, Gobbetti T, Montero-Melendez T, McArthur S, Thompson D, Clark AJL, Flower RJ and Perretti M (2013). Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses. Proc Natl Acad Sci U S A vol. 110, (45) 18232-18237.
Cash JL, Bena S, Headland SE, McArthur S, Brancaleone V and Perretti M (2013). Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23. EMBO Rep vol. 14, (11) 999-1007.
Perretti M, D'Acquisto F and Flower RJ (2013). Annexin-A1 Peptide Ac2-26. Handbook of Biologically Active Peptides
Dalli J, Montero-Melendez T, Norling LV, Yin X, Hinds C, Haskard D, Mayr M and Perretti M (2013). Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. Mol Cell Proteomics vol. 12, (8) 2205-2219.
Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S and Perretti M (2013). A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation. Blood vol. 122, (4) 608-617.
Iqbal AJ, Cooper D, Vugler A, Gittens BR, Moore A and Perretti M (2013). Endogenous galectin-1 exerts tonic inhibition on experimental arthritis. J Immunol vol. 191, (1) 171-177.
Dalli J, Consalvo AP, Ray V, Di Filippo C, D'Amico M, Mehta N and Perretti M (2013). Proresolving and tissue-protective actions of annexin A1-based cleavage-resistant peptides are mediated by formyl peptide receptor 2/lipoxin A4 receptor. J Immunol vol. 190, (12) 6478-6487.
Norling LV and Perretti M (2013). The role of omega-3 derived resolvins in arthritis. Curr Opin Pharmacol vol. 13, (3) 476-481.
Perretti M (2013). SP0144 The Role of Omega-3 Derived Resolvins in Arthritis. Elsevier Annals of the Rheumatic Diseases vol. 72, (Suppl 3)
Gobbetti T, Ducheix S, Le Faouder P, Boue J, Bertrand-Michel J, Guillou H, Perretti M, Vergnolle N and Cenac N (2013). Tu1993 Protective Effects of N-6 Polyunsaturated Fatty Acid Diet on Intestinal Ischemia/Reperfusion Injury Are Centererd on Lipoxin A4 and Its Receptor. Elsevier Gastroenterology vol. 144, (5) s-899.
Ryan SM, McMorrow J, Umerska A, Patel HB, Kornerup KN, Tajber L, Murphy EP, Perretti M, Corrigan OI and Brayden DJ (2013). An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis. J Control Release vol. 167, (2) 120-129.
Montero-Melendez T, Dalli J and Perretti M (2013). Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors. Cell Death Differ vol. 20, (4) 567-575.
Eldridge S, Vicent-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P and Dell'Accio F (2013). Agrin expression is downregulated in OA and is required for chondrocyte differentiation. Elsevier Osteoarthritis and Cartilage vol. 21, s112-s113.
Rhodes DH, Pini M, Castellanos KJ, Montero-Melendez T, Cooper D, Perretti M and Fantuzzi G (2013). Adipose tissue-specific modulation of galectin expression in lean and obese mice: evidence for regulatory function. Obesity (Silver Spring) vol. 21, (2) 310-319.
Schutters K, Kusters DHM, Chatrou MLL, Montero-Melendez T, Donners M, Deckers NM, Krysko DV, Vandenabeele P, Perretti M, Schurgers LJ and Reutelingsperger CPM (2013). Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells. Cell Death Differ vol. 20, (1) 49-56.
Norling LV and Perretti M (2013). Control of myeloid cell trafficking in resolution. J Innate Immun vol. 5, (4) 367-376.
Kosicka A, Cunliffe AD, Mackenzie R, Zariwala MG, Perretti M, Flower RJ and Renshaw D (2013). Attenuation of plasma annexin A1 in human obesity. FASEB JOURNAL vol. 27, (1) 368-378.
Al-Kashi A, Montero-Melendez T, Moradi-Bidhendi N, Gilligan JP, Mehta N and Perretti M (2013). The calcitonin and glucocorticoids combination: mechanistic insights into their class-effect synergy in experimental arthritis. PLoS One vol. 8, (2)
Ahmed TJ, Montero-Melendez T, Perretti M and Pitzalis C (2013). Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides. Int J Inflam vol. 2013,
Godson C and Perretti M (2013). Novel pathways in the yin-yang of immunomodulation. CURRENT OPINION IN PHARMACOLOGY vol. 13, (4) 543-546.
Leoni G, Alam A, Neumann P-A, Lambeth JD, Cheng G, McCoy J, Hilgarth RS, Kundu K, Murthy N, Kusters D, Reutelingsperger C, Perretti M, Parkos CA, Neish AS and Nusrat A (2013). Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. JOURNAL OF CLINICAL INVESTIGATION vol. 123, (1) 443-454.
Pang J, Rhodes DH, Pini M, Akasheh RT, Castellanos KJ, Cabay RJ, Cooper D, Perretti M and Fantuzzi G (2013). Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO mice. PLoS One vol. 8, (2)
Viiri LE, Full LE, Navin TJ, Begum S, Didangelos A, Astola N, Berge RK, Seppala I, Shalhoub J, Franklin IJ, Perretti M, Lehtimaki T, Davies AH, Wait R and Monaco C (2013). Smooth muscle cells in human atherosclerosis: Proteomic profiling reveals differences in expression of Annexin A1 and mitochondrial proteins in carotid disease. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY vol. 54, 65-72.
Ortega-Gomez A, Perretti M and Soehnlein O (2013). Resolution of inflammation: an integrated view. EMBO MOLECULAR MEDICINE vol. 5, (5) 661-674.
Fowkes RC, Moradi-Bidhendi N, Branceleone V, Zariwala MG, Brady D, Jessop DS, Perretti M and Renshaw D (2013). Annexin-A1 protein and its relationship to cortisol in human saliva. PSYCHONEUROENDOCRINOLOGY vol. 38, (5) 722-727.
Sampaio ALF, Dalli J, Brancaleone V, D'Acquisto F, Perretti M and Wheatley C (2013). Biphasic modulation of NOS expression, protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock: downstream regulation of COX-2, IL-1β, TNF-α, IL-6, and HMGB1 expression. Mediators Inflamm vol. 2013,
Montero-Meléndez T, Llor X, García-Planella E, Perretti M and Suárez A (2013). Identification of novel predictor classifiers for inflammatory bowel disease by gene expression profiling. PLoS One vol. 8, (10)
Perretti M, D’Acquisto F and Flower RJ (2013). Chapter 86 Annexin-A1 Peptide Ac2–26. Handbook of Biologically Active Peptides Elsevier
2012
Patel HB, Kornerup KN, Sampaio ALF, D'Acquisto F, Seed MP, Girol AP, Gray M, Pitzalis C, Oliani SM and Perretti M (2012). The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis. Ann Rheum Dis vol. 71, (11) 1872-1880.
Norling LV, Dalli J, Flower RJ, Serhan CN and Perretti M (2012). Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler Thromb Vasc Biol vol. 32, (8) 1970-1978.
Perretti M (2012). Editorial: to resolve or not to resolve: annexin A1 pushes resolution on track. J Leukoc Biol vol. 92, (2) 245-247.
Bena S, Brancaleone V, Wang JM, Perretti M and Flower RJ (2012). Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling. J Biol Chem vol. 287, (29) 24690-24697.
Kabouridis PS, Pimentel TA, Brancaleone V, D'Acquisto F, Oliani SM, Perretti M and Jury EC (2012). Distinct localization of T cell Agrin during antigen presentation--evidence for the expression of Agrin receptor(s) in antigen-presenting cells. FEBS J vol. 279, (13) 2368-2380.
Leinster DA, Kulbe H, Everitt G, Thompson R, Perretti M, Gavins FNE, Cooper D, Gould D, Ennis DP, Lockley M, McNeish IA, Nourshargh S and Balkwill FR (2012). The peritoneal tumour microenvironment of high-grade serous ovarian cancer. J Pathol vol. 227, (2) 136-145.
Liverani E, Banerjee S, Roberts W, Naseem KM and Perretti M (2012). Prednisolone exerts exquisite inhibitory properties on platelet functions. Biochem Pharmacol vol. 83, (10) 1364-1373.
Patel HB, Kornerup KN, Sampaio ALFS, D'Acquisto F, Seed MP, Girol AP, Gray M, Pitzalis C, Oliani SM and Perretti M (2012). The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis. Annals of the Rheumatic Diseases
Cooper D, Iqbal AJ, Gittens BR, Cervone C and Perretti M (2012). The effect of galectins on leukocyte trafficking in inflammation: sweet or sour? Ann N Y Acad Sci vol. 1253, 181-192.
Vincent TL, Williams RO, Maciewicz R, Silman A, Garside P and group FTARUAMW (2012). Mapping pathogenesis of arthritis through small animal models. Oxford University Press (OUP) Rheumatology vol. 51, (11) 1931-1941.
Colom B, Poitelon Y, Huang W, Woodfin A, Averill S, Del Carro U, Zambroni D, Brain SD, Perretti M, Ahluwalia A, Priestley JV, Chavakis T, Imhof BA, Feltri ML and Nourshargh S (2012). Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves. FASEB J vol. 26, (3) 1064-1076.
de Lima CB, Tamura EK, Montero-Melendez T, Palermo-Neto J, Perretti M, Markus RP and Farsky SHP (2012). Actions of translocator protein ligands on neutrophil adhesion and motility induced by G-protein coupled receptor signaling. Biochem Biophys Res Commun vol. 417, (2) 918-923.
Dalli J, Jones CP, Cavalcanti DM, Farsky SH, Perretti M and Rankin SM (2012). Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow. FASEB J vol. 26, (1) 387-396.
Vessillier S, Adams G, Montero-Melendez T, Jones R, Seed M, Perretti M and Chernajovsky Y (2012). Molecular engineering of short half-life small peptides (VIP, αMSH and γ₃MSH) fused to latency-associated peptide results in improved anti-inflammatory therapeutics. Ann Rheum Dis vol. 71, (1) 143-149.
Dalli J, Montero-Melendez T, McArthur S and Perretti M (2012). Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils. Front Pharmacol vol. 3,
Di Filippo C, Perretti M, Rossi F, Ferraraccio F, Motterlini R and D'Amico M (2012). Acute myocardial infarction in streptozotocin-induced hyperglycaemic rats: protection by a carbon monoxide-releasing molecule (CORM-3). NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY vol. 385, (2) 137-144.
Clark AK, Grist J, Al-Kashi A, Perretti M and Malcangio M (2012). Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen-induced arthritis model. ARTHRITIS AND RHEUMATISM vol. 64, (6) 2038-2047.
Vong L, Ferraz JGP, Dufton N, Panaccione R, Beck PL, Sherman PM, Perretti M and Wallace JL (2012). Up-Regulation of Annexin-A1 and Lipoxin A4 in Individuals with Ulcerative Colitis May Promote Mucosal Homeostasis. PLOS ONE vol. 7, (6)
Cardini S, Dalli J, Fineschi S, Perretti M, Lungarella G and Lucattelli M (2012). Genetic Ablation of the Fpr1 Gene Confers Protection from Smoking-Induced Lung Emphysema in Mice. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY vol. 47, (3) 332-339.
2011
Greco KV, Iqbal AJ, Rattazzi L, Nalesso G, Moradi-Bidhendi N, Moore AR, Goldring MB, Dell'Accio F and Perretti M (2011). High density micromass cultures of a human chondrocyte cell line: a reliable assay system to reveal the modulatory functions of pharmacological agents. Biochem Pharmacol vol. 82, (12) 1919-1929.
Nadkarni S, Cooper D, Brancaleone V, Bena S and Perretti M (2011). Activation of the annexin A1 pathway underlies the protective effects exerted by estrogen in polymorphonuclear leukocytes. Arterioscler Thromb Vasc Biol vol. 31, (11) 2749-2759.
Damazo AS, Sampaio AL, Nakata CM, Flower RJ, Perretti M and Oliani SM (2011). Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis. BMC Immunol vol. 12,
Patel HB, Montero-Melendez T, Greco KV and Perretti M (2011). Melanocortin receptors as novel effectors of macrophage responses in inflammation., Editors: Ariel A. Frontiers in Immunology vol. 2, 1-6.
Montero-Melendez T, Patel HB, Seed M, Nielsen S, Jonassen TEN and Perretti M (2011). The melanocortin agonist AP214 exerts anti-inflammatory and proresolving properties. Am J Pathol vol. 179, (1) 259-269.
Roviezzo F, Brancaleone V, De Gruttola L, Vellecco V, Bucci M, D'Agostino B, Cooper D, Sorrentino R, Perretti M and Cirino G (2011). Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo. J Pharmacol Exp Ther vol. 337, (3) 830-837.
Maione F, Cicala C, Liverani E, Mascolo N, Perretti M and D'Acquisto F (2011). IL-17A increases ADP-induced platelet aggregation. Biochem Biophys Res Commun vol. 408, (4) 658-662.
Norling LV, Spite M, Yang R, Flower RJ, Perretti M and Serhan CN (2011). Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing. J IMMUNOL vol. 186, (10) 5543-5547.
Villar IC, Scotland RS, Khambata RS, Chan M, Duchene J, Sampaio AL, Perretti M, Hobbs AJ and Ahluwalia A (2011). Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin. Arterioscler Thromb Vasc Biol vol. 31, (5) 1075-1083.
Brancaleone V, Dalli J, Bena S, Flower RJ, Cirino G and Perretti M (2011). Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature. J Immunol vol. 186, (8) 4905-4914.
Montero-Melendez T, Patel HB and Perretti M (2011). Role of melanocortin receptors in the regulation of gouty inflammation. Curr Rheumatol Rep vol. 13, (2) 138-145.
Iqbal AJ, Sampaio ALF, Maione F, Greco KV, Niki T, Hirashima M, Perretti M and Cooper D (2011). Endogenous galectin-1 and acute inflammation: emerging notion of a galectin-9 pro-resolving effect. Am J Pathol vol. 178, (3) 1201-1209.
Gavins FNE, Li G, Russell J, Perretti M and Granger DN (2011). Microvascular thrombosis and CD40/CD40L signaling. J Thromb Haemost vol. 9, (3) 574-581.
Dufton N, Hannon R, Brancaleone V, Dalli J, Patel HB, Gray M, D'Acquisto F, Buckingham JC, Perretti M and Flower RJ (2011). Corrections: Anti-Inflammatory Role of the Murine Formyl-Peptide Receptor 2: Ligand-Specific Effects on Leukocyte Responses and Experimental Inflammation. The American Association of Immunologists The Journal of Immunology vol. 186, (4) 2684-2685.
Allegra M, D'Acquisto F, Tesoriere L, Livrea MA and Perretti M (2011). Cross-talk between minimally primed HL-60 cells and resting HUVEC reveals a crucial role for adhesion over extracellularly released oxidants. BIOCHEM PHARMACOL vol. 81, (3) 396-401.
Colucci M, Mastriota M, Maione F, Di Giannuario A, Mascolo N, Palmery M, Severini C, Perretti M and Pieretti S (2011). Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids. PEPTIDES vol. 32, (2) 266-271.
Patel HB, Montero-Melendez T, Greco KV and Perretti M (2011). Melanocortin receptors as novel effectors of macrophage responses in inflammation. Front Immunol vol. 2,
Pimentel TA, Sampaio ALF, D'Acquisto F, Perretti M and Oliani SM (2011). An essential role for mast cells as modulators of neutrophils influx in collagen-induced arthritis in the mouse. Lab Invest vol. 91, (1) 33-42.
2010
Maione F, Paschalidis N, Iqbal AJ, Crompton T, Perretti M and D'Acquisto F (2010). Analysis of the inflammatory response in HY-TCR transgenic mice highlights the pathogenic potential of CD4- CD8- T cells. Autoimmunity vol. 43, (8) 672-681.
Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. INT J MOL MED vol. 26, (6) 913-918.
Patel HB, Bombardieri M, Sampaio ALF, D'Acquisto F, Gray M, Grieco P, Getting SJ, Pitzalis C and Perretti M (2010). Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. FASEB J vol. 24, (12) 4835-4843.
Pederzoli-Ribeil M, Maione F, Cooper D, Al-Kashi A, Dalli J, Perretti M and D'Acquisto F (2010). Design and characterization of a cleavage-resistant Annexin A1 mutant to control inflammation in the microvasculature. Blood vol. 116, (20) 4288-4296.
Maderna P, Cottell DC, Toivonen T, Dufton N, Dalli J, Perretti M and Godson C (2010). FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis. FASEB J vol. 24, (11) 4240-4249.
Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. Spandidos Publications International Journal of Molecular Medicine vol. 26, (6) 913-918.
Renshaw D, Montero-Melendez T, Dalli J, Kamal A, Brancaleone V, D'Acquisto F, Cirino G and Perretti M (2010). Downstream gene activation of the receptor ALX by the agonist annexin A1. PLoS One vol. 5, (9)
Yazid S, Leoni G, Getting SJ, Cooper D, Solito E, Perretti M and Flower RJ (2010). Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization. Arterioscler Thromb Vasc Biol vol. 30, (9) 1718-1724.
Patel HB, Bombardieri M, Sampaio ALF, D’Acquisto F, Gray M, Grieco P, Getting SJ, Pitzalis C and Perretti M (2010). Anti‐inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. Wiley The FASEB Journal vol. 24, (12) 4835-4843.
Dufton N and Perretti M (2010). Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists. Pharmacol Ther vol. 127, (2) 175-188.
Dalli J, Rosignoli G, Hayhoe RPG, Edelman A and Perretti M (2010). CFTR Inhibition Provokes an Inflammatory Response Associated with an Imbalance of the Annexin A1 Pathway. AM J PATHOL vol. 177, (1) 176-186.
Sampaio ALF, Zahn G, Leoni G, Vossmeyer D, Christner C, Marshall JF and Perretti M (2010). Inflammation-dependent alpha 5 beta 1 (very late antigen-5) expression on leukocytes reveals a functional role for this integrin in acute peritonitis. J Leukoc Biol vol. 87, (5) 877-884.
Leoni G, Voisin M-B, Carlson K, Getting S, Nourshargh S and Perretti M (2010). The melanocortin MC(1) receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature. Br J Pharmacol vol. 160, (1) 171-180.
Semple F, Webb S, Li HN, Patel HB, Perretti M, Jackson IJ, Gray M, Davidson DJ and Dorin JR (2010). Human beta-defensin 3 has immunosuppressive activity in vitro and in vivo. EUR J IMMUNOL vol. 40, (4) 1073-1078.
Dufton N, Hannon R, Brancaleone V, Dalli J, Patel HB, Gray M, D'Acquisto F, Buckingham JC, Perretti M and Flower RJ (2010). Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. J Immunol vol. 184, (5) 2611-2619.
Sarndahl E, Bergstrom I, Nijm J, Forslund T, Perretti M and Jonasson L (2010). Enhanced neutrophil expression of annexin-1 in coronary artery disease. METABOLISM vol. 59, (3) 433-440.
Paschalidis N, Huggins A, Rowbotham NJ, Furmanski AL, Crompton T, Flower RJ, Perretti M and D'Acquisto F (2010). Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection. CELL CYCLE vol. 9, (4) 785-794.
Patel HB, Leoni G, Melendez TM, Sampaio ALF and Perretti M (2010). Melanocortin Control of Cell Trafficking in Vascular Inflammation.
Hunter C, Kadakia TB, Cooper D, Perretti M, Schwartz RC and Brown SB (2010). Selective Inhibitors of Kv11.1 Regulate IL-6 Expression by Macrophages in Response to TLR/IL-1R Ligands. THESCIENTIFICWORLDJOURNAL vol. 10, 1580-1596.
Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. International Journal of Molecular Medicine vol. 26, (6) 913-918.
Di Filippo C, Monopoli A, Ongini E, Perretti M and D'Amico M (2010). The Cardio-Protective Properties of Ncx-6550, a Nitric Oxide Donating Pravastatin, in the Mouse. MICROCIRCULATION vol. 17, (6) 417-426.
Cooper D, Ilarregui JM, Pesoa SA, Croci DO, Perretti M and Rabinovich GA (2010). Multiple functional targets of the immunoregulatory activity of galectin-1: Control of immune cell trafficking, dendritic cell physiology, and T-cell fate.
Spurr L, Nadkarni S, Pederzoli-Ribeil M, Goulding NJ, Perretti M and D'Acquisto F (2010). Comparative analysis of Annexin A1-Formyl Peptide Receptor 2/ALX expression in human leukocyte subsets. Elsevier International Immunopharmacology vol. 11, (1) 55-66.
2009
Paschalidis N, Iqbal AJ, Maione F, Wood EG, Perretti M, Flower RJ and D'Acquisto F (2009). Modulation of experimental autoimmune encephalomyelitis by endogenous annexin A1. J Neuroinflammation vol. 6,
Duchene J, Cayla C, Vessillier S, Scotland R, Yamashiro K, Lecomte F, Syed I, Vo P, Marrelli A, Pitzalis C, Cipollone F, Schanstra J, Bascands J-L, Hobbs AJ, Perretti M and Ahluwalia A (2009). Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis. Arterioscler Thromb Vasc Biol vol. 29, (11) 1757-1763.
Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M and Serhan CN (2009). Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. NATURE vol. 461, (7268) 1287-U125.
Perretti M and Dalli J (2009). Exploiting the Annexin A1 pathway for the development of novel anti-inflammatory therapeutics. Br J Pharmacol vol. 158, (4) 936-946.
Pieretti S, di Giannuario A, Colucci M, Mastriota M and Perretti M (2009). 297 INVESTIGATION OF THE ROLE OF FORMYL PEPTIDE RECEPTOR IN ACUTE NOCICEPTION USING GENE‐DEFICIENT MICE. Wiley European Journal of Pain vol. 13, (S1) s92a-ss92.
McColl A, Bournazos S, Franz S, Perretti M, Morgan BP, Haslett C and Dransfield I (2009). Glucocorticoids Induce Protein S-Dependent Phagocytosis of Apoptotic Neutrophils by Human Macrophages. J IMMUNOL vol. 183, (3) 2167-2175.
Dufton NP, Hannon R, Perretti M and Flower R (2009). Quantitative Analysis of Promoter Activity by Green Fluorescent Protein (GFP) Target/Reporter Strategy in a Novel Transgenic alx/fpr-rs2 Null Mouse. Springer Nature Inflammation Research vol. 58, (Suppl 2) s252-s255.
Piqueras L, Sanz MJ, Perretti M, Morcillo E, Norling L, Mitchell JA, Li Y and Bishop-Bailey D (2009). Activation of PPAR beta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release. J LEUKOCYTE BIOL vol. 86, (1) 115-122.
Norling LV, Perretti M and Cooper D (2009). Endogenous galectins and the control of the host inflammatory response. J Endocrinol vol. 201, (2) 169-184.
Patel HB, Bombardieri M, Pitzalis C and Perretti M (2009). Activation of melanocortin receptor type 3 as a new strategy to control experimental and rheumatoid arthritis. EUR J CLIN INVEST vol. 39, 29-29.
Pederzoli-Ribeil M, Maione F, Perretti M and D'Acquisto F (2009). The impact of Annexin-A1 cleavage on neutrophil behaviour during vascular inflammation. EUR J CLIN INVEST vol. 39, 37-37.
Huggins A, Paschalidis N, Flower RJ, Perretti M and D'Acquisto F (2009). Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation. FASEB J vol. 23, (4) 985-996.
Tripatara P, Patel NSA, Brancaleone V, Renshaw D, Rocha J, Sepodes B, Mota-Filipe H, Perretti M and Thiemermann C (2009). Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study. Eur J Pharmacol vol. 606, (1-3) 205-209.
Maione F, Paschalidis N, Mascolo N, Dufton N, Perretti M and D'Acquisto F (2009). Interleukin 17 sustains rather than induces inflammation. Biochem Pharmacol vol. 77, (5) 878-887.
Hecht I, Rong J, Sampaio ALF, Hermesh C, Rutledge C, Shemesh R, Toporik A, Beiman M, Dassa L, Niv H, Cojocaru G, Zauberman A, Rotman G, Perretti M, Vinten-Johansen J and Cohen Y (2009). A Novel Peptide Agonist of Formyl-Peptide Receptor-Like 1 (ALX) Displays Anti-Inflammatory and Cardioprotective Effects. J PHARMACOL EXP THER vol. 328, (2) 426-434.
Gastardelo TS, Damazo AS, Dalli J, Flower RJ, Perretti M and Oliani SM (2009). Functional and Ultrastructural Analysis of Annexin A1 and Its Receptor in Extravasating Neutrophils during Acute Inflammation. AM J PATHOL vol. 174, (1) 177-183.
Perretti M and D'Acquisto F (2009). Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. Nat Rev Immunol vol. 9, (1) 62-70.
Laukoetter MG, Babbin BA, Nava P, Koch S, Lee WY, Capaldo CT, Peatman E, Severson EA, Flower RJ, Perretti M, Parkos CA and Nusrat A (2009). Annexin A1 reguliert intestinale Mukosaschäden, Entzündung und Regeneration. Chirurgisches Forum und DGAV Forum 2009 Springer Nature
2008
Getting SJ, Riffo-Vasquez Y, Pitchford S, Kaneva M, Grieco P, Page CP, Perretti M and Spina D (2008). A role for MC3R in modulating lung inflammation. PULM PHARMACOL THER vol. 21, (6) 866-873.
Leoni G, Patel HB, Sampaio ALF, Gavins FNE, Murray JF, Grieco P, Getting SJ and Perretti M (2008). Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion. FASEB J vol. 22, (12) 4228-4238.
Babbin BA, Laukoetter MG, Nava P, Koch S, Lee WY, Capaldo CT, Peatman E, Severson EA, Flower RJ, Perretti M, Parkos CA and Nusrat A (2008). Annexin A1 regulates intestinal mucosal injury, inflammation, and repair. J IMMUNOL vol. 181, (7) 5035-5044.
Oliani SM, Ciocca GAP, Pimentel TA, Damazo AS, Gibbs L and Perretti M (2008). Fluctuation of annexin-A1 positive mast cells in chronic granulomatous inflammation. INFLAMM RES vol. 57, (10) 450-456.
Dalli J, Norling LV, Renshaw D, Cooper D, Leung KY and Perretti M (2008). Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. BLOOD vol. 112, (6) 2512-2519.
D'Acquisto F, Perretti M and Flower RJ (2008). Annexin-A1: a pivotal regulator of the innate and adaptive immune systems. BRIT J PHARMACOL vol. 155, (2) 152-169.
D'Acquisto F and Perretti M (2008). Overview of the Role of Annexin 1 in the Innate and Adaptive Immune Response. Bentham Science Publishers Immunology Endocrine & Metabolic Agents - Medicinal Chemistry vol. 8, (3) 252-258.
Dufton N, Buckingham J, Perretti M and Flower R (2008). Initial characterisation of the novel transgenic, the alx/fpr-rs2 null mouse. FUND CLIN PHARMACOL vol. 22, 48-48.
Cooper D, Norling LV and Perretti M (2008). Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. J LEUKOCYTE BIOL vol. 83, (6) 1459-1466.
D'Acquisto F, Paschalidis N, Raza K, Buckley CD, Flower RJ and Perretti M (2008). Glucocorticoid treatment inhibits annexin-1 expression in rheumatoid arthritis CD4+ T cells. Rheumatology (Oxford) vol. 47, (5) 636-639.
Sarndahl E, Bergstrom I, Nijm J, Perretti M and Jonasson L (2008). ENHANCED NEUTROPHIL EXPRESSION OF ANNEXIN-1 IN CORONARY ARTERY DISEASE. ATHEROSCLEROSIS SUPP vol. 9, (1) 15-15.
Yona S, Lin HH, Dri P, Davies JQ, Hayhoe RPG, Lewis SM, Heinsbroek SEM, Brown KA, Perretti M, Hamann J, Treacher DF, Gordon S and Stacey M (2008). Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function. FASEB J vol. 22, (3) 741-751.
Martin GR, Perretti M, Flower RJ and Wallace JL (2008). Annexin-1 modulates repair of gastric mucosal injury. AM J PHYSIOL-GASTR L vol. 294, (3) G764-G769.
Norling LV, Sampaio ALF, Cooper D and Perretti M (2008). Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking. FASEB J vol. 22, (3) 682-690.
2007
Finney SJ, Anning PB, Cao TV, Perretti M, Evans TW and Burke-Gaffney A (2007). Butanol-extracted lipoteichoic acid induces in vivo leukocyte adhesion. BIOCHEM BIOPH RES CO vol. 364, (4) 831-837.
O'Sullivan TP, Vallin KSA, Shah STA, Fakhry J, Maderna P, Scannell M, Sampaio ALF, Perretti M, Godson C and Guiry PJ (2007). Aromatic lipoxin A(4) and lipoxin B-4 analogues display potent biological activities. J MED CHEM vol. 50, (24) 5894-5902.
D'Acquisto F, Paschalidis N, Sampaio ALF, Merghani A, Flower RJ and Perretti M (2007). Impaired T cell activation and increased Th2 lineage commitment in Annexin-1-deficient T cells. EUR J IMMUNOL vol. 37, (11) 3131-3142.
Vong L, D'Acquisto F, Pederzoli-Ribeil M, Lavagno L, Flower RJ, Witko-Sarsat R and Perretti M (2007). Annexin 1 cleavage in activated neutrophils - A pivotal role for proteinase 3. J BIOL CHEM vol. 282, (41) 29998-30004.
Perretti M and Mancini L (2007). Potential of calcitonin as a novel cotreatment for arthritis. OMICS International International Journal of Clinical Rheumatology vol. 2, (5) 493-496.
Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M and Ahluwalia A (2007). A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5. J Immunol vol. 179, (7) 4849-4856.
Gavins FNE, Dalli J, Flower RJ, Granger DN and Perretti M (2007). Activation of the annexin 1 counter-regulatory circuit affords protection in the mouse brain microcirculation. FASEB J vol. 21, (8) 1751-1758.
Urquhart P, Rosignoli G, Cooper D, Motterlini R and Perretti M (2007). Carbon monoxide-releasing molecules modulate leukocyte-endothelial interactions under flow. J Pharmacol Exp Ther vol. 321, (2) 656-662.
John CD, Sahni V, Mehet D, Morris JF, Christian HC, Perretti M, Flower RJ, Solito E and Buckingham JC (2007). Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin A1, lipoxins, and bacterial peptides. FASEB J vol. 21, (4) 1037-1046.
Giner RM, Mancini L, Kamal AM and Perretti M (2007). Uneven modulation of the annexin 1 system in osteoblast-like cells by dexamethasone. BIOCHEM BIOPH RES CO vol. 354, (2) 414-419.
Mancini L, Paul-Clark MJ, Rosignoli G, Hannon R, Martin JE, Macintyre I and Perretti M (2007). Calcitonin and prednisolone display antagonistic actions on bone and have synergistic effects in experimental arthritis. AM J PATHOL vol. 170, (3) 1018-1027.
Perretti M (2007). Glucocorticoids in innate immunity: more transactivation than transrepression! BLOOD vol. 109, (3) 852-853.
Serhan CN, Brain SD, Buckley CD, Gilroy DW, Haslett C, O'Neill LAJ, Perretti M, Rossi AG and Wallace JL (2007). Resolution of inflammation: state of the art, definitions and terms. FASEB J vol. 21, (2) 325-332.
D'Acquisto F, Merghani A, Lecona E, Rosignoli G, Raza K, Buckley CD, Flower RJ and Perretti M (2007). Annexin-1 modulates T-cell activation and differentiation. Blood vol. 109, (3) 1095-1102.
2006
Getting SJ, Lam CW, Leoni G, Gavins FNE, Grieco P and Perretti M (2006). [D-Trp(8)]-gamma-melanocyte-stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse). MOL PHARMACOL vol. 70, (6) 1850-1855.
Sawmynaden P and Perretti M (2006). Glucocorticoid upregulation of the annexin-A1 receptor in leukocytes. Biochem Biophys Res Commun vol. 349, (4) 1351-1355.
Renshaw D, Urquhart P and Perretti M (2006). Therapeutic Exploitation of Endogenous Anti-Inflammatory Mechanisms:Old and New Leads. Bentham Science Publishers Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry vol. 5, (4) 289-305.
Getting SJ, Lam CW, Chen AS, Grieco P and Perretti M (2006). Melanocortin 3 receptors control crystal-induced inflammation. FASEB J vol. 20, (13) 2234-2241.
Kamal AM, Hayhoe RPG, Paramasivam A, Cooper D, Flower RJ, Solito E and Perretti M (2006). Antiflammin-2 activates the human formyl-peptide receptor like 1. ScientificWorldJournal vol. 6, 1375-1384.
Flower RJ, Ayoub S and Perretti M (2006). Anti-inflammatory and analgesic aspects of the annexin A1 system. ACTA PHARMACOL SIN vol. 27, (9) 1272-1272.
Cassatella MA and Perretti M (2006). Immunomodulation The promises of immunopharmacology for the development of new drugs. Elsevier Current Opinion in Pharmacology vol. 6, (4) 376-378.
Flower RJ, Perretti M, D'Acquisto F and Buckingham JC (2006). Annexin 1, anti-inflammatory drugs and the neuroendocrine-immune interface. ACTA PHARMACOL SIN vol. 27, 13-14.
Yona S, Heinsbroek SEM, Peiser L, Gordon S, Perretti M and Flower RJ (2006). Impaired phagocytic mechanism in annexin 1 null macrophages. BRIT J PHARMACOL vol. 148, (4) 469-477.
Perretti M and D'Acquisto F (2006). Novel aspects of annexin 1 and glucocorticoid biology: intersection with nitric oxide and the lipoxin receptor. Inflamm Allergy Drug Targets vol. 5, (2) 107-114.
Gil CD, La M, Perretti M and Oliani SM (2006). Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin-1 and galectin-3. CELL BIOL INT vol. 30, (4) 338-344.
Damazo AS, Yona S, Flower RJ, Perretti M and Oliani SM (2006). Spatial and temporal profiles for anti-inflammatory gene expression in leukocytes during a resolving model of peritonitis. J IMMUNOL vol. 176, (7) 4410-4418.
Hayhoe RPG, Kamal AM, Solito E, Flower RJ, Cooper D and Perretti M (2006). Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement. BLOOD vol. 107, (5) 2123-2130.
Getting SJ, Di Filippo C, D'Amico M and Perretti M (2006). The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage. EUR J PHARMACOL vol. 532, (1-2) 138-144.
Lam CW, Perretti M and Getting SJ (2006). Melanocortin receptor signaling in RAW264.7 macrophage cell line. Peptides vol. 27, (2) 404-412.
Perretti M, COOPER D, Gil CD, Oliani SM and Rosignoli G (2006). Inflammation-induced modulation of cellular galectin-1 and –3 expression in a model of rat peritonitis. inflammation Research vol. 55, (3) 99-107.
PERRETTI M, Nusrat A, Akyildiz A, Parkos CA, Babbin BA, Lee WY and Winfree LM (2006). Annexin I regulates SKCO-15 cell invasion by signaling through formyl peptide receptors. J Biol Chem vol. 281, 19588-19599.
2005
Moraes LA, Paul-Clark MJ, Rickman A, Flower RJ, Goulding NJ and Perretti M (2005). Ligand-specific glucocorticoid receptor activation in human platelets. Blood vol. 106, (13) 4167-4175.
Bensalem N, Ventura AP, Vallee B, Lipecka J, Tondelier D, Davezac N, Dos Santos A, Perretti M, Fajac A, Sermet-Gaudelus I, Renouil M, Lesure JF, Halgand F, Laprevote O and Edelman A (2005). Down-regulation of the anti-inflammatory protein annexin A1 in cystic fibrosis knock-out mice and patients. MOL CELL PROTEOMICS vol. 4, (10) 1591-1601.
Chatterjee BE, Yona S, Rosignoli G, Young RE, Nourshargh S, Flower RJ and Perretti M (2005). Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro. J Leukoc Biol vol. 78, (3) 639-646.
Gilroy DW and Perretti M (2005). Aspirin and steroids: new mechanistic findings and avenues for drug discovery. CURR OPIN PHARMACOL vol. 5, (4) 405-411.
Yona S, Heinsbroek S, Gordon S, Perretti M and Flower RJ (2005). A novel role for Annexin 1 in macrophage phagocytosis. INFLAMM RES vol. 54, S217-S218.
Marchand F, Perretti M and McMahon SB (2005). Role of the immune system in chronic pain. NAT REV NEUROSCI vol. 6, (7) 521-532.
Damazo AS, Yona S, D'Acquisto F, Flower RJ, Oliani SM and Perretti M (2005). Critical protective role for annexin 1 gene expression in the endotoxemic murine microcirculation. AM J PATHOL vol. 166, (6) 1607-1617.
Maderna P, Yona S, Perretti M and Godson C (2005). Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide AC(2-26). J IMMUNOL vol. 174, (6) 3727-3733.
Flower RJ and Perretti M (2005). Controlling inflammation: a fat chance? J Exp Med vol. 201, (5) 671-674.
Kamal AM, Flower RJ and Perretti M (2005). An overview of the effects of annexin 1 on cells involved in the inflammatory process. Mem Inst Oswaldo Cruz vol. 100 Suppl 1, 39-47.
Zanardo RCO, Perretti M and Wallace JL (2005). Annexin-1 is an endogenous gastroprotective factor against indomethacin-induced damage. AM J PHYSIOL-GASTR L vol. 288, (3) G481-G486.
Basoni C, Nobles M, Grimshaw A, Desgranges C, Davies D, Perretti M, Kramer IM and Genot E (2005). Inhibitory control of TGF-beta 1 on the activation of Rap1, CD11b, and transendothelial migration of leukocytes. FASEB J vol. 19, (3) 822-+.
Lam CW, Getting SJ and Perretti M (2005). In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation. J IMMUNOL vol. 174, (4) 2297-2304.
Yona S, Ward B, Buckingham JC, Perretti M and Flower RJ (2005). Macrophage biology in the Anx-A1-/- mouse. Prostaglandins Leukot Essent Fatty Acids vol. 72, (2) 95-103.
Flower RJ, PERRETTI M, Diaz BL, Bandeira-Melo C, Martins MA, Carvalho VF, Silva PM, Jose PJ and Bonavita AG (2005). A novel effect for annexin 1-derived peptide ac2-26: reduction of allergic inflammation in the rat. J Pharmacol Exp Ther vol. 313, (3) 1416-1422.
Gavins FNE, Sawmynaden P, Chatterjee BE and Perretti M (2005). A twist in anti-inflammation: annexin 1 acts via the lipoxin A4 receptor. Prostaglandins Leukot Essent Fatty Acids vol. 73, (3-4) 211-219.
Alam CAS, Seed MP, Freemantle C, Brown J, Perretti M, Carrier M, Divwedi A, West DC, Gustafson S, Colville-Nash PR and Willoughby DA (2005). The inhibition of neutrophil-endothelial cell adhesion by hyaluronan independent of CD44. Inflammopharmacology vol. 12, (5-6) 535-550.
Gavins FNE, Kamal AM, D'Amico M, Oliani SM and Perretti M (2005). Formyl-peptide receptor is not involved in the protection afforded by annexin 1 in murine acute myocardial infarct. FASEB J vol. 19, (1) 100-102.
2004
Cao TV, La M, Getting SJ, Day AJ and Perretti M (2004). Inhibitory effects of TSG-6 link module on leukocyte-endothelial cell interactions in vitro and in vivo. MICROCIRCULATION vol. 11, (7) 615-624.
Getting SJ, Di Filippo C, Christian HC, Lam CW, Rossi F, D'Amico M and Perretti M (2004). MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct. J LEUKOCYTE BIOL vol. 76, (4) 845-853.
Di Filippo C, Rossi F, Ongini E, Del Soldato P, Perretti M and D'Amico M (2004). The distinct alterations produced in cardiovascular functions by prednisolone and nitro-prednisolone (NCX-1015) in the rat highlight a causal role for endothelin-1. J PHARMACOL EXP THER vol. 310, (3) 1133-1141.
Yona S, Buckingham JC, Perretti M and Flower RJ (2004). Stimulus-specific defect in the phagocytic pathways of annexin 1 null macrophages. Br J Pharmacol vol. 142, (5) 890-898.
Perretti M and Flower RJ (2004). Annexin 1 and the biology of the neutrophil. J Leukoc Biol vol. 76, (1) 25-29.
MARTIN JE, Flower RJ, Perretti M, Hannon R, Getting SJ, Gavins FNE, Christian HC, Parente L, Paul-Clark MJ, Yona S, Oliani SM, Wells D, Cover PO, John CD, Solito E, Morris JF, Buckingham JC, Wells K, Liu K, Croxtall JD and Damazo AS (2004). The Annexin 1-/- Mouse: Phenotypic Studies. Annexins vol. 1, (2) 109-120.
Perretti M and Solito E (2004). Annexin 1 and neutrophil apoptosis. BIOCHEMICAL SOCIETY TRANSACTIONS vol. 32, 507-510.
Pieretti S, Di Giannuario A, De Felice M, Perretti M and Cirino G (2004). Stimulus-dependent specificity for annexin 1 inhibition of the inflammatory nociceptive response: the involvement of the receptor for formylated peptides. PAIN vol. 109, (1-2) 52-63.
Gilroy DW, Lawrence T, Perretti M and Rossi AG (2004). Inflammatory resolution: new opportunities for drug discovery. Nat Rev Drug Discov vol. 3, (5) 401-416.
Young RE, Thompson RD, Larbi KY, La M, Roberts CE, Shapiro SD, Perretti M and Nourshargh S (2004). Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo. J IMMUNOL vol. 172, (7) 4493-4502.
Yang YH, Morand EF, Getting SJ, Paul-Clark M, Liu DL, Yona S, Hannon R, Buckingham JC, Perretti M and Flower RJ (2004). Modulation of inflammation and response to dexamethasone by annexin 1 in antigen-induced arthritis. ARTHRITIS RHEUM vol. 50, (3) 976-984.
Ahluwalia A, Foster P, Scotland RS, McLean PG, Mathur A, Perretti M, Moncada S and Hobbs AJ (2004). Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. P NATL ACAD SCI USA vol. 101, (5) 1386-1391.
Baraldi PG, Romagnoli R, Nunez MD, Perretti M, Paul-Clark MJ, Ferrario M, Govoni M, Benedini F and Ongini E (2004). Synthesis of nitro esters of prednisolone, new compounds combining pharmacological properties of both glucocorticoids and nitric oxide. J MED CHEM vol. 47, (3) 711-719.
Moraes LA, Giner RM, Paul-Clark MJ, Perretti M and Perrett D (2004). An isocratic HPLC method for the quantitation of eicosanoids in human platelets. BIOMED CHROMATOGR vol. 18, (1) 64-68.
PERRETTI M, Oliani SM, Takahashi HK, Damazo AS, Paul-Clark MJ and Straus AH (2004). Analysis of annexin 1 expression in rat trachea: study of mast cell heterogeneity. ANNEXINS vol. 1, 12-18.
2003
Perretti M (2003). The annexin 1 receptor(s): is the plot unravelling? TRENDS PHARMACOL SCI vol. 24, (11) 574-579.
La M, Cao TV, Cerchiaro G, Chilton K, Hirabayashi J, Kasao K, Oliani SM, Chernajovsky Y and Perretti M (2003). A novel biological activity for galectin-1 - Inhibition of leukocyte-endothelial cell interactions in experimental inflammation. AM J PATHOL vol. 163, (4) 1505-1515.
Paul-Clark MJ, Roviezzo F, Flower RJ, Cirino G, Del Soldato P, Adcock IM and Perretti M (2003). Glucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands. J IMMUNOL vol. 171, (6) 3245-3252.
Getting SJ, Schioth HB and Perretti M (2003). Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides. J PHARMACOL EXP THER vol. 306, (2) 631-637.
Solito E, Kamal A, Russo-Marie F, Buckingham JC, Marullo S and Perretti M (2003). A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils. FASEB J vol. 17, (9) 1544-+.
Gavins FNE, Yona S, Kamal AM, Flower RJ and Perretti M (2003). Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms. Blood vol. 101, (10) 4140-4147.
Perretti M, Paul-Clark MJ, Mancini L and Flower RJ (2003). Generation of innovative anti-inflammatory and anti-arthritic glucocorticoid derivatives that release NO: the nitro-steroids. DIGEST LIVER DIS vol. 35, S41-S48.
Perretti M and Gavins FNE (2003). Annexin 1: an endogenous anti-inflammatory protein. News Physiol Sci vol. 18, 60-64.
Getting SJ, Christian HC, Lam CW, Gavins FNE, Flower RJ, Schioth HB and Perretti M (2003). Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: Studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor. J IMMUNOL vol. 170, (6) 3323-3330.
Hannon R, Croxtall JD, Getting SJ, Roviezzo F, Yona S, Paul-Clark MJ, Gavins FNE, Perretti M, Morris JF, Buckingham JC and Flower RJ (2003). Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. FASEB J vol. 17, (2) 253-255.
PERRETTI M and Parente L (2003). Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight. Biochemical Pharmacology vol. 65, (2) 153-159.
Perretti M and Getting SJ (2003). Migration of specific leukocyte subsets in response to cytokine or chemokine application in vivo.
Perretti M and Getting SJ (2003). Migration of Specific Leukocyte Subsets in Response to Cytokine or Chemokine Application In Vivo. Inflammation Protocols Springer Nature
2002
Getting SJ, Mahoney DJ, Cao T, Rugg MS, Fries E, Milner CM, Perretti M and Day AJ (2002). The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner. J Biol Chem vol. 277, (52) 51068-51076.
Fiorucci S, Antonelli E, Distrutti E, Del Soldato P, Flower RJ, Clark MJP, Morelli A, Perretti M and Ignarro LJ (2002). NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice. P NATL ACAD SCI USA vol. 99, (24) 15770-15775.
Perretti M, Chiang N, La M, Fierro IM, Marullo S, Getting SJ, Solito E and Serhan CN (2002). Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nat Med vol. 8, (11) 1296-1302.
Getting SJ, Christian HC, Flower RJ and Perretti M (2002). Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis. Arthritis Rheum vol. 46, (10) 2765-2775.
Perretti M, Ingegnoli F, Wheller SK, Blades MC, Solito E and Pitzalis C (2002). Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model. J Immunol vol. 169, (4) 2085-2092.
Gibbs L, Carollo MG, Damazo AS, Oliani SM and Perretti M (2002). Time-dependent expression of annexin 1 in a model of chronic granulomatous inflammation. INFLAMM RES vol. 51, (6) 300-306.
Blades MC, Manzo A, Ingegnoli F, Taylor PR, Panayi GS, Irjala H, Jalkanen S, Haskard DO, Perretti M and Pitzalis C (2002). Stromal cell-derived factor 1 (CXCL12) induces human cell migration into human lymph nodes transplanted into SCID mice. J IMMUNOL vol. 168, (9) 4308-4317.
Calatayud S, Mitchell JA, Perretti M, Giuliano F and Warner TD (2002). Effects of cyclooxygenase-1/cyclooxygenase-2 inhibition on leukocyte/endothelial cell interactions in the rat mesentery. EUR J PHARMACOL vol. 440, (1) 71-77.
Ajuebor MN, Swain MG and Perretti M (2002). Chemokines as novel therapeutic targets in inflammatory diseases. BIOCHEM PHARMACOL vol. 63, (7) 1191-1196.
Blades MC, Ingegnoli F, Wheller SK, Manzo A, Wahid S, Panayi GS, Perretti M and Pitzalis C (2002). Stromal cell-derived factor 1 (CXCL12) induces monocyte migration into human synovium transplanted onto SCID mice. ARTHRITIS RHEUM vol. 46, (3) 824-836.
Malcangio M, Getting S, Grist J, Cunningham JR, Bradbury EJ, Issa PC, Lever IJ, Pezet S and Perretti M (2002). A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones. FASEB J vol. 16, (3) 730-+.
Paul-Clark MJ, Mancini L, Del Soldato P, Flower RJ and Perretti M (2002). Potent antiarthritic properties of a glucocorticoid derivative, NCX-1015, in an experimental model of arthritis. P NATL ACAD SCI USA vol. 99, (3) 1677-1682.
PERRETTI M, Damazo AS and Oliani SM (2002). Annexin 1 localisation in tissue eosinophils as detected by electron microscopy. MEDiators of INFLAMMation. vol. 11, 287-292.
Ingegnoli F, Blades M, Manzo A, Wahid S, Perretti M, Panayi G and Pitzalis C (2002). Role of cell migration in the pathogenesis of rheumatoid arthritis: in vivo studies in SCID mice transplanted with human synovial membrane. PAGEPress Publications Reumatismo vol. 54, (2) 128-132.
Malcangio M, Getting SJ, Grist J, Cunningham JR, Bradbury EJ, Charbel Issa P, Lever IJ, Pezet S and Perretti M (2002). A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol. 16, (7) 730-732.
PERRETTI M, Manzo A, Wheller SK, Ingegnoli F, Blades MC, Petzalis C, Wahid S and Panayi GS (2002). Stromal cell derived factor-1 (CXCL 12) induces monocyte migration into human synovium transplanted onto SCID mice. ARTH RHEUM vol. 46, 824-836.
2001
Das AM, Ajuebor MN, Flower RJ, Perretti M and Mccoll SR (2001). Contrasting roles for RANTES and macrophage inflammatory protein-1α (MIP-1α) in a murine model of allergic peritonitis. Oxford University Press (OUP) Clinical & Experimental Immunology vol. 117, (2) 223-229.
Carollo M, Hogaboam CM, Kunkel SL, Delaney S, Christie MI and Perretti M (2001). Analysis of the temporal expression of chemokines and chemokine receptors during experimental granulomatous inflammation: role and expression of MIP-1alpha and MCP-1. Br J Pharmacol vol. 134, (6) 1166-1179.
Mabley JG, Jagtap P, Perretti M, Getting SJ, Salzman AL, Virag L, Szabo E, Soriano FG, Liaudet L, Abdelkarim GE, Hasko G, Marton A, Southan GJ and Szabo C (2001). Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. INFLAMM RES vol. 50, (11) 561-569.
La M, Tailor A, D'Amico M, Flower RJ and Perretti M (2001). Analysis of the protection afforded by annexin 1 in ischaemia-reperfusion injury: focus on neutrophil recruitment. Eur J Pharmacol vol. 429, (1-3) 263-278.
de Coupade C, Ajuebor MN, Russo-Marie F, Perretti M and Solito E (2001). Cytokine modulation of liver annexin 1 expression during experimental endotoxemia. AM J PATHOL vol. 159, (4) 1435-1443.
Damazo AS, de Lima WT, Perretti M and Oliani SM (2001). Pharmacological modulation of allergic inflammation in the rat airways and association with mast cell heterogeneity. EUR J PHARMACOL vol. 426, (1-2) 123-130.
Getting SJ and Perretti M (2001). Arthritic diseases: melanocortin type 3 receptor agonists as potential therapeutics. Current Opinion in Investigational Drugs vol. 2, (8) 1064-1069.
Henderson RB, Lim LHK, Tessier PA, Gavins FNE, Mathies M, Perretti M and Hogg N (2001). The use of lymphocyte function-associated antigen (LFA)-1-deficient mice to determine the role of LFA-1, Mac-1, and alpha 4 integrin in the inflammatory response of neutrophils. J EXP MED vol. 194, (2) 219-226.
Perretti M, Getting SJ, Solito E, Murphy PM and Gao JL (2001). Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. AM J PATHOL vol. 158, (6) 1969-1973.
Diaz B, Barreto E, Cordeiro R, Perretti M, Martins M and Silva P (2001). Enhanced serum glucocorticoid levels mediate the reduction of serosal mast cell numbers in diabetic rats. LIFE SCI vol. 68, (26) 2925-2932.
Solito E, de Coupade C, Canaider S, Goulding NJ and Perretti M (2001). Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase-3 activation. BRIT J PHARMACOL vol. 133, (2) 217-228.
Blades MC, Ingegnoli F, Manzo A, Wahid S, Haskard D, Panayi G, Perretti M and Pitzalis C (2001). Development of a new model to investigate lymphocyte migration into human peripheral lymph nodes (HPLN) transplanted into SCID mice. RHEUMATOLOGY vol. 40, 66-66.
Oliani SM, Paul-Clark MJ, Christian HC, Flower RJ and Perretti M (2001). Neutrophil interaction with inflamed postcapillary venule endothelium alters annexin 1 expression. AM J PATHOL vol. 158, (2) 603-615.
PERRETTI M, Obinger C, Furtmuller PG, Allegra M, Regelsberger G, Livrea MA, Tesoriere L and Turco-Leveri ML (2001). Mechanism of Reaction of Melatonin with Human Myeloperoxidase. Biochem Biophys Res commun. vol. 282, 380-386.
Oliani SM, Lim LHK, Christian HC, Pell K, Das AM and Perretti M (2001). Morphological alteration of peritoneal mast cells and macrophages in the mouse peritoneal cavity during the early phases of an allergic inflammatory reaction. CELL BIOL INT vol. 25, (8) 795-803.
Pitzalis C, Pipitone N and Perretti M (2001). Glucocorticoids and leukocyte adhesion. Glucocorticoids Springer Nature
Allcock GH, Allegra M, Flower RJ and Perretti M (2001). Neutrophil accumulation induced by bacterial lipopolysaccharide: effects of dexamethasone and annexin 1. CLIN EXP IMMUNOL vol. 123, (1) 62-67.
Getting SJ, Allcock GH, Flower R and Perretti M (2001). Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties. J Leukoc Biol vol. 69, (1) 98-104.
2000
Mancini L, Moradi-Bidhendi N, Brandi ML, Perretti M and MacIntyre I (2000). Modulation of the effects of osteoprotegerin (OPG) ligand in a human leukemic cell line by OPG and calcitonin. BIOCHEM BIOPH RES CO vol. 279, (2) 391-397.
Paul‐Clark M, Del Soldato P, Fiorucci S, Flower RJ and Perretti M (2000). 21‐NO‐prednisolone is a novel nitric oxide‐releasing derivative of prednisolone with enhanced anti‐inflammatory properties. Wiley British Journal of Pharmacology vol. 131, (7) 1345-1354.
McLean PG, Perretti M and Ahluwalia A (2000). Kinin B1 receptors and the cardiovascular system: regulation of expression and function. Oxford University Press (OUP) Cardiovascular Research vol. 48, (2) 194-210.
D'Amico M, Di Filippo C, La M, Solito E, McLean PG, Flower RJ, Oliani SM and Perretti M (2000). Lipocortin 1 reduces myocardial ischemia-reperfusion injury by affecting local leukocyte recruitment. FASEB J vol. 14, (13) 1867-1869.
Oliani SM, Christian HC, Manston J, Flower RJ and Perretti M (2000). An Immunocytochemical and In Situ Hybridization Analysis of Annexin 1 Expression in Rat Mast Cells: Modulation by Inflammation and Dexamethasone. Elsevier Laboratory Investigation vol. 80, (9) 1429-1438.
McLean PG, Ahluwalia A and Perretti M (2000). Association between Kinin B1 Receptor Expression and Leukocyte Trafficking across Mouse Mesenteric Postcapillary Venules. Rockefeller University Press Journal of Experimental Medicine vol. 192, (3) 367-380.
Perretti M and Page CP (2000). Heparin and inflammation: a new use for an old GAG? BMJ Gut vol. 47, (1)
Lim LHK, Flower RJ, Perretti M and Das AM (2000). Glucocorticoid Receptor Activation Reduces CD11b and CD49d Levels on Murine Eosinophils. American Thoracic Society American Journal of Respiratory Cell and Molecular Biology vol. 22, (6) 693-701.
PERRETTI M and AHLUWALIA A (2000). The Microcirculation and Inflammation: Site of Action for Glucocorticoids. Wiley Microcirculation vol. 7, (3) 147-161.
Getting SJ and Perretti M (2000). MC3-R as a novel target for antiinflammatory therapy. Drug News and Perspectives vol. 13, (1) 19-27.
McLean PG, Perretti M and Ahluwalia A (2000). Kinin B1 receptors as novel anti-inflammatory targets. Taylor & Francis Expert Opinion on Therapeutic Targets vol. 4, (2) 127-141.
Canaider S, Solito E, de Coupade C, Flower RJ, Russo-Marie F, Goulding NJ and Perretti M (2000). Increased apoptosis in U937 cells over-expressing lipocortin 1 (annexin I). Life Sci vol. 66, (18) PL265-PL270.
Perretti M, Christian H, Wheller SK, Aiello I, Mugridge KG, Morris JF, Flower RJ and Goulding NJ (2000). ANNEXIN I IS STORED WITHIN GELATINASE GRANULES OF HUMAN NEUTROPHIL AND MOBILIZED ON THE CELL SURFACE UPON ADHESION BUT NOT PHAGOCYTOSIS. Wiley Cell Biology International vol. 24, (3) 163-174.
1999
Tailor A, Tomlinson A, Salas A, Panés J, Granger DN, Flower RJ and Perretti M (1999). Dexamethasone inhibition of leucocyte adhesion to rat mesenteric postcapillary venules: role of intercellular adhesion molecule 1 and KC. BMJ Gut vol. 45, (5)
McLean PG, Perretti M and Ahluwalia A (1999). Inducible expression of the kinin B1 receptor in the endotoxemic heart: mechanisms of des‐Arg9bradykinin‐induced coronary vasodilation. Wiley British Journal of Pharmacology vol. 128, (2) 275-282.
Getting SJ, Gibbs L, Clark AJL, Flower RJ and Perretti M (1999). POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation. The American Association of Immunologists The Journal of Immunology vol. 162, (12) 7446-7453.
Perretti M, Wheller SK, Flower RJ, Wahid S and Pitzalis C (1999). Modulation of cellular annexin I in human leukocytes infiltrating DTH skin reactions. Oxford University Press (OUP) Journal of Leukocyte Biology vol. 65, (5) 583-589.
Ahluwalia A and Perretti M (1999). B1 receptors as a new inflammatory target. Could this B the 1? Elsevier Trends in Pharmacological Sciences vol. 20, (3) 100-104.
Minghetti L, Nicolini A, Polazzi E, Greco A, Perretti M, Parente L and Levi G (1999). Down‐regulation of microglial cyclo‐oxygenase‐2 and inducible nitric oxide synthase expression by lipocortin 1. Wiley British Journal of Pharmacology vol. 126, (6) 1307-1314.
Ajuebor MN, Das AM, Virág L, Flower RJ, Szabó C and Perretti M (1999). Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL-10. The American Association of Immunologists The Journal of Immunology vol. 162, (3) 1685-1691.
Ajuebor MN, Das AM, Virág L, Szabó C and Perretti M (1999). Regulation of Macrophage Inflammatory Protein-1α Expression and Function by Endogenous Interleukin-10 in a Model of Acute Inflammation. Elsevier Biochemical and Biophysical Research Communications vol. 255, (2) 279-282.
Euzger HS, Flower RJ, Goulding NJ and Perretti M (1999). Differential Modulation of Annexin I Binding Sites on Monocytes and Neutrophils. Wiley Mediators of Inflammation vol. 8, (1) 53-62.
Ruetten H, Thiemermann C and Perretti M (1999). Upregulation of ICAM‐1 Expression on J774.2 Macrophages by Endotoxin Involves Activation of NF‐κB but not Protein Tyrosine Kinase: Comparison to Induction of iNOS. Wiley Mediators of Inflammation vol. 8, (2) 77-84.
1998
AJUEBOR , VIRÁG , FLOWER , PERRETTI and SZABÓ (1998). Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan‐induced inflammation. Wiley Immunology vol. 95, (4) 625-630.
Lim LH, Solito E, Russo-Marie F, Flower RJ and Perretti M (1998). Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A vol. 95, (24) 14535-14539.
Perretti M (1998). Lipocortin 1 and Chemokine Modulation of Granulocyte and Monocyte Accumulation in Experimental Inflammation. Elsevier Vascular Pharmacology vol. 31, (4) 545-552.
Ajuebor MN, Gibbs L, Flower RJ, Das AM and Perretti M (1998). Investigation of the functional role played by the chemokine monocyte chemoattractant protein‐1 in interleukin‐1‐induced murine peritonitis. Wiley British Journal of Pharmacology vol. 125, (2) 319-326.
Das AM, Flower RJ and Perretti M (1998). Resident mast cells are important for eotaxin-induced eosinophil accumulation in vivo. Oxford University Press (OUP) Journal of Leukocyte Biology vol. 64, (2) 156-162.
Ahluwalia A, De Felipe C, O'Brien J, Hunt SP and Perretti M (1998). Impaired IL‐1β‐induced neutrophil accumulation in tachykinin NK1 receptor knockout mice. Wiley British Journal of Pharmacology vol. 124, (6) 1013-1015.
Pistritto G, Mancuso C, Tringali G, Perretti M, Preziosi P and Navarra P (1998). The relative contribution of constitutive and inducible cyclooxygenase activity to lipopolysaccharide-induced prostaglandin production by primary cultures of rat hypothalamic astrocytes. Elsevier Neuroscience Letters vol. 246, (1) 45-48.
Bryant CE, Perretti M and Flower RJ (1998). Suppression by Dexamethasone of Inducible Nitric Oxide Synthase Protein Expression In Vivo A Possible Role for Lipocortin 1. Elsevier Biochemical Pharmacology vol. 55, (3) 279-285.
Teixeira MM, Das AM, Miotla JM, Perretti M and Hellewell PG (1998). The role of lipocortin‐1 in the inhibitory action of dexamethasone on eosinophil trafficking in cutaneous inflammatory reactions in the mouse. Wiley British Journal of Pharmacology vol. 123, (3) 538-544.
Ajuebor MN, Flower RJ, Hannon R, Christie M, Bowers K, Verity A and Perretti M (1998). Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model. Oxford University Press (OUP) Journal of Leukocyte Biology vol. 63, (1) 108-116.
1997
Cuzzocrea S, Tailor A, Zingarelli B, Salzman AL, Flower RJ, Szabó C and Perretti M (1997). Lipocortin 1 protects against splanchnic artery occlusion and reperfusion injury by affecting neutrophil migration. The American Association of Immunologists The Journal of Immunology vol. 159, (10) 5089-5097.
Perretti M (1997). Endogenous mediators that inhibit the leukocyte– endothelium interaction. Elsevier Trends in Pharmacological Sciences vol. 18, (11) 418-425.
Szabó C, Lim LHK, Cuzzocrea S, Getting SJ, Zingarelli B, Flower RJ, Salzman AL and Perretti M (1997). Inhibition of poly (ADP-ribose) Synthetase Attenuates Neutrophil Recruitment and Exerts Antiinflammatory Effects. Rockefeller University Press Journal of Experimental Medicine vol. 186, (7) 1041-1049.
Getting SJ, Flower RJ, Parente L, de Medicis R, Lussier A, Woliztky BA, Martins MA and Perretti M (1997). Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. Journal of Pharmacology and Experimental Therapeutics vol. 283, (1) 123-130.
Tailor A, Flower RJ and Perretti M (1997). Dexamethasone inhibits leukocyte emigration in rat mesenteric post-capillary venules: an intravital microscopy study. Oxford University Press (OUP) Journal of Leukocyte Biology vol. 62, (3) 301-308.
Das AM, Flower RJ and Perretti M (1997). Eotaxin-induced eosinophil migration in the peritoneal cavity of ovalbumin-sensitized mice: mechanism of action. The American Association of Immunologists The Journal of Immunology vol. 159, (3) 1466-1473.
Ferreira SH, Cunha FQ, Lorenzetti BB, Michelin MA, Perretti M, Flower RJ and Poole S (1997). Role of lipocortin‐1 in the anti‐hyperalgesic actions of dexamethasone. Wiley British Journal of Pharmacology vol. 121, (5) 883-888.
Wheller SK and Perretti M (1997). Dexamethasone inhibits cytokine-induced intercellular adhesion molecule-1 up-regulation on endothelial cell lines. Elsevier European Journal of Pharmacology vol. 331, (1) 65-71.
Das AM, Flower RJ, Hellewell PG, Teixeira MM and Perretti M (1997). A novel murine model of allergic inflammation to study the effect of dexamethasone on eosinophil recruitment. Wiley British Journal of Pharmacology vol. 121, (1) 97-104.
Getting SJ, Flower RJ and Perretti M (1997). Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1. Wiley British Journal of Pharmacology vol. 120, (6) 1075-1082.
Tailor A, Das AM, Getting SJ, Flower RJ and Perretti M (1997). Subacute Treatment of Rats with Dexamethasone Reduces ICAM-1 Levels on Circulating Monocytes. Elsevier Biochemical and Biophysical Research Communications vol. 231, (3) 675-678.
Das AM, Lim LHK, Flower RJ and Perretti M (1997). Dexamethasone reduces cell surface levels of CD11b on human eosinophils. Wiley Mediators of Inflammation vol. 6, (5-6) 363-367.
1996
Perretti M, Croxtall JD, Wheller SK, Goulding NJ, Hannon R and Flower RJ (1996). Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration. Springer Nature Nature Medicine vol. 2, (11) 1259-1262.
Harris JG, Flower RJ, Watanabe K, Tsurufuji S, Wolitzky BA and Perretti M (1996). Relative Contribution of the Selectins in the Neutrophil Recruitment Caused by the Chemokine Cytokine-Induced Neutrophil Chemoattractant (CINC) Volume221,Number 3 (1996), pages 692–696. Elsevier Biochemical and Biophysical Research Communications vol. 224, (3) 878-879.
Perretti M, Wheller SK, Harris JG and Flower RJ (1996). Modulation of ICAM-1 Levels on U-937 Cells and Mouse Macrophages by Interleukin-1β and Dexamethasone. Elsevier Biochemical and Biophysical Research Communications vol. 223, (1) 112-117.
Perretti M and Flower RJ (1996). Measurement of lipocortin 1 levels in murine peripheral blood leukocytes by flow cytometry: modulation by glucocorticoids and inflammation. Wiley British Journal of Pharmacology vol. 118, (3) 605-610.
Harris JG, Flower RJ, Watanabe K, Tsurufuji S, Wolitzky BA and Perretti M (1996). Relative Contribution of the Selectins in the Neutrophil Recruitment Caused by the Chemokine Cytokine-Induced Neutrophil Chemoattractant (CINC). Elsevier Biochemical and Biophysical Research Communications vol. 221, (3) 692-696.
Malcangio M, Bowery NG, Flower RJ and Perretti M (1996). Effect of interleukin-1β on the release of substance P from rat isolated spinal cord. Elsevier European Journal of Pharmacology vol. 299, (1-3) 113-118.
Perretti M, Ahluwalia A, Harris JG, Harris HJ, Wheller SK and Flower RJ (1996). Acute inflammatory response in the mouse: exacerbation by immunoneutralization of lipocortin 1. Wiley British Journal of Pharmacology vol. 117, (6) 1145-1154.
Ahluwalia A and Perretti M (1996). Involvement of bradykinin B1 receptors in the polymorphonuclear leukocyte accumulation induced by IL-1 beta in vivo in the mouse. The American Association of Immunologists The Journal of Immunology vol. 156, (1) 269-274.
1995
Mugridge KG, Perretti M, Ghiara P, Galeotti CL, Melli M and Parente L (1995). Gastric antisecretory and anti-ulcer actions of IL-1 in rat involve different IL-1 receptor types. American Physiological Society American Journal of Physiology vol. 269, (5) g763-g769.
Perretti M, Szabó C and Thiemermann C (1995). Effect of interleukin‐4 and interleukin‐10 on leucocyte migration and nitric oxide production in the mouse. Wiley British Journal of Pharmacology vol. 116, (4) 2251-2257.
Perretti M, Wheller SK, Choudhury Q, Croxtall JD and Flower RJ (1995). Selective inhibition of neutrophil function by a peptide derived from lipocortin 1 N-terminus. Elsevier Biochemical Pharmacology vol. 50, (7) 1037-1042.
Harris JG, Flower RJ and Perretti M (1995). Endogenous corticosteroids mediate the neutrophilia caused by platelet-activating factor in the mouse. Elsevier European Journal of Pharmacology vol. 283, (1-3) 9-18.
Mancuso F, Flower RJ and Perretti M (1995). Leukocyte transmigration, but not rolling or adhesion, is selectively inhibited by dexamethasone in the hamster post-capillary venule. Involvement of endogenous lipocortin 1. The American Association of Immunologists The Journal of Immunology vol. 155, (1) 377-386.
Klemm P, Harris HJ and Perretti M (1995). Effect of rolipram in a murine model of acute inflammation: comparison with the corticoid dexamethasone. Elsevier European Journal of Pharmacology vol. 281, (1) 69-74.
Palmi M, Frosini M, Sgaragli GP, Becherucci C, Perretti M and Parente L (1995). Inhibition of interleukin-1β-induced pyresis in the rabbit by peptide 204–212 of lipocortin 5. Elsevier European Journal of Pharmacology vol. 281, (1) 97-99.
Harris JG, Flower RJ and Perretti M (1995). Alteration of neutrophil trafficking by a lipocortin 1 N-terminus peptide. Elsevier European Journal of Pharmacology vol. 279, (2-3) 149-157.
Wu CC, Croxtall JD, Perretti M, Bryant CE, Thiemermann C, Flower RJ and Vane JR (1995). Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 92, (8) 3473-3477.
Perretti M and Flower RJ (1995). Anti-Inflammatory Lipocortin-Derived Peptides. Novel Molecular Approaches to Anti-Inflammatory Therapy
1994
Ahluwalia A and Perretti M (1994). Calcitonin gene-related peptides modulate the acute inflammatory response induced by interleukin-1 in the mouse. Elsevier European Journal of Pharmacology vol. 264, (3) 407-415.
Perretti M and Flower RJ (1994). Cytokines, glucocorticoids and lipocortins in the control of neutrophil migration. Elsevier Pharmacological Research vol. 30, (1) 53-59.
Perretti M, Harris JG and Flower RJ (1994). A role for endogenous histamine in interleukin‐8‐induced neutrophil infiltration into mouse air‐pouch: investigation of the modulatory action of systemic and local dexamethasone. Wiley British Journal of Pharmacology vol. 112, (3) 801-808.
Ahluwalia A and Perretti M (1994). Anti-inflammatory effect of prostanoids in mouse and rat skin: evidence for a role of EP3-receptors. Journal of Pharmacology and Experimental Therapeutics vol. 268, (3) 1526-1531.
Perretti M (1994). Lipocortin-derived peptides. Elsevier Biochemical Pharmacology vol. 47, (6) 931-938.
Szabó C, Thiemermann C, Wu CC, Perretti M and Vane JR (1994). Attenuation of the induction of nitric oxide synthase by endogenous glucocorticoids accounts for endotoxin tolerance in vivo. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 91, (1) 271-275.
1993
Perretti M, Ahluwalia A, Harris JG, Goulding NJ and Flower RJ (1993). Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody. The American Association of Immunologists The Journal of Immunology vol. 151, (8) 4306-4314.
Perretti M, Duncan GS, Flower RJ and Peers SH (1993). Serum corticosterone, interleukin‐1 and tumour necrosis factor in rat experimental endotoxaemia: comparison between Lewis and Wistar strains. Wiley British Journal of Pharmacology vol. 110, (2) 868-874.
Perretti M, Ahluwalia A, Flower RJ and Manzini S (1993). Endogenous tachykinins play a role in IL-1-induced neutrophil accumulation: involvement of NK-1 receptors. Immunology vol. 80, (1) 73-77.
Thiemermann C, Wu C, Szabó C, Perretti M and Vane JR (1993). Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock. Wiley British Journal of Pharmacology vol. 110, (1) 177-182.
Perretti M, Flower RJ and Goulding NJ (1993). The Ability of Murine Leukocytes to Bind Lipocortin 1 Is Lost during Acute Inflammation. Elsevier Biochemical and Biophysical Research Communications vol. 192, (2) 345-350.
Cirino G, Cicala C, Sorrentino L, Ciliberto G, Arpaia G, Perretti M and Flower RJ (1993). Anti‐inflammatory actions of an N‐terminal peptide from human lipocortin 1. Wiley British Journal of Pharmacology vol. 108, (3) 573-574.
Da Silva JA, Peers SH, Perretti M and Willoughby DA (1993). Sex steroids affect glucocorticoid response to chronic inflammation and to interleukin-1. Bioscientifica Journal of Endocrinology vol. 136, (3) 389-397.
Perretti M and Flower RJ (1993). Modulation of IL-1-induced neutrophil migration by dexamethasone and lipocortin 1. The American Association of Immunologists The Journal of Immunology vol. 150, (3) 992-999.
Mugridge KG, Becherucci C, Parente L and Perretti M (1993). Inhibition of smooth muscle contraction and platelet aggregation by peptide 204–212 of lipocortin 5: an attempt to define some structure requirements. Wiley Mediators of Inflammation vol. 2, (2) 103-107.
Becherucci C, Perretti M, Solito E, Galeotti CL and Parente L (1993). Conceivable difference in the anti-inflammatory mechanisms of lipocortins 1 and 5. Mediators Inflamm vol. 2, (2) 109-113.
1992
Douglas GJ, Flower RJ, Parente L and Perretti M (1992). Peptide 204–212 of lipocortin 5 inhibits the generation of a prostacyclin-like factor from rat aorta preparations in vitro. Elsevier Prostaglandins vol. 44, (5) 381-388.
Parente L, Perretti M, Wallace JL and Mugridge KG (1992). Mechanism of the protective action of interleukin-1 in the experimental gastric damage in the rat. Elsevier Pharmacological Research vol. 26, 28-29.
Perretti M, Mugridge KG, Wallace JL and Parente L (1992). Reduction of aspirin-induced gastric damage in rats by interleukin-1 beta: possible involvement of endogenous corticosteroids. Journal of Pharmacology and Experimental Therapeutics vol. 261, (3) 1238-1247.
Becherucci C, Perretti M, Nencioni L, Silvestri S and Parente L (1992). Anti-inflammatory effect of tuftsin and its retro-inverso analogue in rat adjuvant arthritis. Springer Nature Inflammation Research vol. 36, (Suppl 1) c115-c117.
Perretti M, Solito E and Parente L (1992). Evidence that endogenous interleukin-1 is involved in leukocyte migration in acute experimental inflammation in rats and mice. Agents Actions vol. 35, (1-2) 71-78.
1991
Verdini AS, Silvestri S, Becherucci C, Longobardi MG, Parente L, Peppoloni S, Perretti M, Pileri P, Pinori M and Viscomi GC (1991). Immunostimulation by a partially modified retro-inverso-tuftsin analogue containing Thr1 psi[NHCO](R,S)Lys2 modification. American Chemical Society (ACS) Journal of Medicinal Chemistry vol. 34, (12) 3372-3379.
Perretti M, Mugridge KG, Becherucci C and Parente L (1991). Evidence that interleukin-1 and lipoxygenase metabolites mediate the lethal effect of complete Freund's adjuvant in adrenalectomized rats. Journal of Interferon & Cytokine Research vol. 10, (4) 239-243.
Perretti M, Becherucci C, Mugridge KG, Solito E, Silvestri S and Parente L (1991). A novel anti-inflammatory peptide from human lipocortin 5. Br J Pharmacol vol. 103, (2) 1327-1332.
Mugridge KG, Perretti M, Ghiara P and Parente L (1991). α-melanocyte-stimulating hormone reduces interleukin-lβ effects on rat stomach preparations possibly through interference with a type I receptor. Elsevier European Journal of Pharmacology vol. 197, (2-3) 151-155.
Dal Piaz V, Ciciani G, Turco G, Giovannoni MP, Miceli M, Pirisino R and Perretti M (1991). 5‐Acyl‐6‐Aryl‐4‐Nitro‐3(2HH)Pyridazinones and related 4‐amino compounds: Synthesis and pharmacological evaluation. Elsevier Journal of Pharmaceutical Sciences vol. 80, (4) 341-348.
Mugridge KG, Perretti M and Parente L (1991). 5-Lipoxygenase activation may facilitate an interleukin-1 transduction signal. Advances in Prostaglandin, Thromboxane, and Leukotriene Research vol. 21B, 517-520.
Mugridge KG, Perretti M, Becherucci C and Parente L (1991). Persistent effects of interleukin-1 on smooth muscle preparations from adrenalectomized rats: implications for increased phospholipase-A2 activity via stimulation of 5-lipoxygenase. Journal of Pharmacology and Experimental Therapeutics vol. 256, (1) 29-37.
1990
Perretti M, Mugridge KG, Becherucci C, Silvestri S and Parente L (1990). Antiulcer property of human recombinant interleukin-1β. Elsevier Pharmacological Research vol. 22,
Parente L, Mugridge KG, Perretti M and Solito E (1990). In vitro and in vivo activation of phospholipase A2 by interleukin-1. Elsevier Pharmacological Research vol. 22,
Becherucci C, Perretti M, Galeotti C and Parente L (1990). Different anti-inflammatory effects of lipocortins 1 and 5. Elsevier Pharmacological Research vol. 22,
Perretti M, Nuti S and Parente L (1990). Investigation of rat mast cell degranulation using flow cytometry. Elsevier Journal of Pharmacological Methods vol. 23, (3) 187-194.
Becherucci C, Solito E, Perretti M, Mugridge KG, Galeotti CL and Parente L (1990). Purification and biological activity of human lipocortin 2. Pharmacol Res vol. 22 Suppl 1, 29-30.
Parente L, Becherucci C, Perretti M, Solito E, Mugridge KG, Galeotti CL, Raugei G, Melli M and Sanso M (1990). Are the lipocortins the second messengers of the anti-inflammatory action of glucocorticoids? Prog Clin Biol Res vol. 349, 55-68.
1989
Perretti M, Becherucci C, Scapigliati G and Parente L (1989). The effect of adrenalectomy on interleukin‐1 release in vitro and in vivo. Wiley British Journal of Pharmacology vol. 98, (4) 1137-1142.
Becherucci C, Donati D, Perretti M and Parente L (1989). The release of interleukin-1-like activity by macrophages in two models of immunological inflammation in the rat. Springer Nature Inflammation Research vol. 28, (3-4) 243-247.
1988
Perretti M, Becherucci C and Parente L (1988). Interleukin-1 release by macrophages from adrenalectomized (ADX) and shamoperated (SHO) rats. Elsevier Pharmacological Research Communications vol. 20,
Becherucci C, Donati D, Perretti M and Parente L (1988). Interleukin-1 release by rat macrophages in experimental immunological inflammation. Elsevier Pharmacological Research Communications vol. 20,
Ignesti G, Buffoni F, Perretti M and Cintelli A (1988). Induction and quail liver diamine oxidase (histaminase). Part II: Different responses to the inducers. Springer Nature Inflammation Research vol. 25, (1-2) 43-47.
Ignesti G, Perretti M and Buffoni F (1988). Induction and quail liver diamine oxidase (histaminase). Part I: Interference of spermidine synthase on the diamine oxidase activity assay using putrescine as substrate. Springer Nature Inflammation Research vol. 25, (1-2) 37-42.
1986
Ignesti G, Perretti M and Buffoni F (1986). Diamine oxidase activity in Japanese quail liver induced with Aroclor 1254. Springer Nature Inflammation Research vol. 18, (1-2) 41-43.
1981
Bombardieri G, Bevilacqua E, Conti LR, Innocenti P and Perretti MA (1981). Plasma amine oxidases in Wilson's disease. Elsevier Life Sciences vol. 29, (2) 117-120.
Grants
Grants of specific relevance to Predictive in vitro Models
Anti-inflammatory and Pro-resolving profiles of south Africa medicinal plants
Mauro Perretti and Roberto Buccafusca
£282,802 Royal Society (07-10-2024 - 06-10-2026)
Mauro Perretti and Roberto Buccafusca
£282,802 Royal Society (07-10-2024 - 06-10-2026)
Assessing the pro-resolving and anti-arthritic properties of cannabidiol in chronic inflammation
Mauro Perretti and Lucy Norling
£130,358 WHRL William Harvey Research Limited (01-10-2024 - 31-03-2026)
Mauro Perretti and Lucy Norling
£130,358 WHRL William Harvey Research Limited (01-10-2024 - 31-03-2026)
Blood analysis protocol: Efficacy of RTP026 in MI patients
Mauro Perretti, Jianmin Chen and Sharmilee Gnanapavan
£261,605 WHRL William Harvey Research Limited (01-09-2024 - 28-02-2027)
Mauro Perretti, Jianmin Chen and Sharmilee Gnanapavan
£261,605 WHRL William Harvey Research Limited (01-09-2024 - 28-02-2027)
Arthritic Mice (STIA & KBxN F1 Samples)
Mauro Perretti
£12,821 WHRL William Harvey Research Limited (01-06-2024 - 31-05-2025)
Mauro Perretti
£12,821 WHRL William Harvey Research Limited (01-06-2024 - 31-05-2025)
Repurposing Alpha-1-antitrypsin as a treatment for post-traumatic osteoarthritis
Mauro Perretti and Magdalena Kaneva
£566,515 MRC Medical Research Council (01-05-2024 - 30-04-2027)
Mauro Perretti and Magdalena Kaneva
£566,515 MRC Medical Research Council (01-05-2024 - 30-04-2027)
Melancortins to control cystic fibrosis airway inflammation
Mauro Perretti, Charles Mein and Lucy Norling
£21,271 Italian Cystic Fibrosis Research Foundation Fondazione Italiana per la ricerca sulla Fibrosi Cistica (01-12-2023 - 30-11-2025)
Mauro Perretti, Charles Mein and Lucy Norling
£21,271 Italian Cystic Fibrosis Research Foundation Fondazione Italiana per la ricerca sulla Fibrosi Cistica (01-12-2023 - 30-11-2025)
rhu-pGelsolin for treatment of arthritis
Mauro Perretti, Magdalena Kaneva and Shafaq Sikandar
£460,135 BioAegis Therapeutics (01-02-2023 - 31-01-2025)
Mauro Perretti, Magdalena Kaneva and Shafaq Sikandar
£460,135 BioAegis Therapeutics (01-02-2023 - 31-01-2025)
Harmonised IAA grant - Improve and accelerate the impact of QMUL research MRC
Mauro Perretti, Tatjana Crnogorac-Jurcevic and David Lee
£457,000 MRC Medical Research Council (01-04-2022 - 31-03-2026)
Mauro Perretti, Tatjana Crnogorac-Jurcevic and David Lee
£457,000 MRC Medical Research Council (01-04-2022 - 31-03-2026)
Testing novel peptides
Mauro Perretti
£45,706 WHRL William Harvey Research Limited (01-01-2022 - 31-12-2026)
Mauro Perretti
£45,706 WHRL William Harvey Research Limited (01-01-2022 - 31-12-2026)
Analysis of novel melanocortin receptor peptide agonists - phase 2
Mauro Perretti and Trinidad Montero Melendez
£374,313 WHRL William Harvey Research Limited (01-04-2021 - 31-03-2025)
Mauro Perretti and Trinidad Montero Melendez
£374,313 WHRL William Harvey Research Limited (01-04-2021 - 31-03-2025)
AP1189 as a novel therapeutic for human joint disease
£192,488 WHRL William Harvey Research Limited (04-12-2012 - 31-12-2025)
£192,488 WHRL William Harvey Research Limited (04-12-2012 - 31-12-2025)
Exploring the resolution of inflammation for innovative target discovery
£162,290 WHRL William Harvey Research Limited (01-02-2012 - 31-12-2024)
£162,290 WHRL William Harvey Research Limited (01-02-2012 - 31-12-2024)
INBRX-101 for cartilage regeneration in osteoarthritis
Magdalena Kaneva and Mauro Perretti
£97,499 INHIBRIX (01-02-2022 - 31-01-2024)
Magdalena Kaneva and Mauro Perretti
£97,499 INHIBRIX (01-02-2022 - 31-01-2024)
HORIZON-HLTH-2022-DISEASE-06-two-stage pump priming
Mauro Perretti and Stavros Fotiadis
£8,336 British Academy (01-01-2022 - 30-06-2022)
Mauro Perretti and Stavros Fotiadis
£8,336 British Academy (01-01-2022 - 30-06-2022)
CardiomyopathyinRA
Mauro Perretti and Lucy Norling
£230,741 Bristol-Myers Squibb Pharmaceuticals Ltd (01-05-2021 - 31-12-2023)
Mauro Perretti and Lucy Norling
£230,741 Bristol-Myers Squibb Pharmaceuticals Ltd (01-05-2021 - 31-12-2023)
New therapeutic targets for treating the failing heart in arthritis.
Mauro Perretti and Dianne Cooper
£121,382 WHRF William Harvey Research Foundation (01-04-2021 - 31-03-2024)
Mauro Perretti and Dianne Cooper
£121,382 WHRF William Harvey Research Foundation (01-04-2021 - 31-03-2024)
A New Therapeutic Approach to Cardioprotection for Myocardial Infarct Patients
£143,668 Barts and the London Charity (01-03-2020 - 31-08-2022)
£143,668 Barts and the London Charity (01-03-2020 - 31-08-2022)