Dr Neil McCarthy
MRC Career Development Fellow; Senior Lecturer in Immunology
CPM Theme lead - Infectious Disease & Inflammation Models
Centre for Immunobiology, The Blizard Institute
Queen Mary University of London
Queen Mary University of London
Research
Intestine, Inflammation, Candida, Fungus, Crohn's disease, Ulcerative colitis
Interests
The McCarthy lab studies host–pathogen interactions at mucosal surfaces, with a particular focus on γδ T-cells and their role in gut barrier protection against microbial infection and inflammation. The ultimate aim of this work is to understand how γδ T-cell function becomes dysregulated in inflammatory bowel disease (IBD) and could potentially be restored by novel agonist / antagonist immunotherapies.Publications
2025
Immunotherapeutic targeting of aging-associated isoDGR motif in chronic lung inflammation.Kalailingam P, Ngan SC, Iyappan R, Nehchiri A, Mohd-Kahliab K-H, Lee BST, Sharma B, Machan R, Bo ST, Chambers ES, Fajardo VA, Macpherson REK, Liu J, Klentrou P, Tsiani EL, Lim KL, Su IH, Gao Y-G, Richar AM, Kalaria RN, Chen CP, Balion C, de Kleijn D, McCarthy NE and Sze SK
Aging Cell
05-01-2025
2024
P145 Phagocyte responses to gut-derived C. albicans are modified in inflammatory bowel diseaseMathew L, Carlson S, Savage M, Pardieu C, Sze N, Munro C, Naglik J, Stagg A, Kok K, Lindsay JO and McCarthy N
Journal of Crohn's and Colitis, Oxford University Press (Oup) vol. 18 (Supplement_1), i446-i446.
24-01-2024
γδ T cells respond directly and selectively to the skin commensal yeast Malassezia for IL-17-dependent fungal controlRuchti F, Tuor M, Mathew L, McCarthy NE and LeibundGut-Landmann S
Plos Pathogens, Public Library of Science (Plos) vol. 20 (1)
12-01-2024
IL-21 conditions antigen-presenting human γδ T-cells to promote IL-10 expression in naïve and memory CD4+ T-cellsTyler CJ, Hoti I, Griffiths DD, Cuff SM, Andrews R, Keisker M, Ahmed R, Hansen HP, Lindsay JO, Stagg AJ, Moser B, McCarthy NE and Eberl M
Discovery Immunology, Oxford University Press (Oup) vol. 3 (1)
01-01-2024
2023
Immunotherapy targeting isoDGR‐protein damage extends lifespan in a mouse model of protein deamidationKalailingam P, Mohd‐Kahliab K, Ngan SC, Iyappan R, Melekh E, Lu T, Zien GW, Sharma B, Guo T, MacNeil AJ, MacPherson RE, Tsiani EL, O'Leary DD, Lim KL, Su IH, Gao Y, Richards AM, Kalaria RN, Chen CP, McCarthy NE and Sze SK
Embo Molecular Medicine, Springer Nature vol. 15 (12)
16-11-2023
Mucosal Immunity to Gut Fungi in Health and Inflammatory Bowel DiseaseCarlson SL, Mathew L, Savage M, Kok K, Lindsay JO, Munro CA and McCarthy NE
Journal of Fungi, Mdpi vol. 9 (11)
14-11-2023
Endothelial Damage Arising From High Salt Hypertension Is Elucidated by Vascular Bed Systematic ProfilingVinaiphat A, Pazhanchamy K, JebaMercy G, Ngan SC, Leow MK-S, Ho HH, Gao Y-G, Lim KL, Richards AM, de Kleijn DPV, Chen CP, Kalaria RN, Liu J, O’Leary DD, McCarthy NE and Sze SK
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 43 (3), 427-442.
26-01-2023
2022
pSILAC-Based Determination of Cellular Protein Sorting into Extracellular VesiclesNgan S-FC, McCarthy NE and Sze SK
Methods in Molecular Biology, Springer Nature vol. 2603, 43-58.
13-11-2022
OP37 Bacterial suppression of intestinal fungi via activation of human gut Vδ2+ T-cellsMathew L, Savage M, Pardieu C, O’Brien M, Sze SK, Eberl M, Stagg A, Gasparetto M, Kok K, Lindsay J and McCarthy N
Journal of Crohn's and Colitis, Oxford University Press (Oup) vol. 16 (Supplement_1), i043-i044.
21-01-2022
2021
Prebiotic fructans have greater impact on luminal microbiology and CD3+ T cells in healthy siblings than patients with Crohn's disease: A pilot study investigating the potential for primary prevention of inflammatory bowel diseaseHedin CR, McCarthy NE, Louis P, Farquharson FM, McCartney S, Stagg AJ, Lindsay JO and Whelan K
Clinical Nutrition, Elsevier vol. 40 (8), 5009-5019.
23-06-2021
Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosisPark JE, JebaMercy G, Pazhanchamy K, Guo X, Ngan SC, Liou KCK, Lynn SE, Ng SS, Meng W, Lim SC, Leow MK-S, Richards AM, Pennington DJ, de Kleijn DPV, Sorokin V, Ho HH, McCarthy NE and Sze SK
Atherosclerosis, Elsevier vol. 324, 58-68.
25-03-2021
2020
Patients with gastrointestinal irritability after TGN1412-induced cytokine storm displayed selective expansion of gut-homing αβ and γδT cellsMcCarthy NE, Stagg AJ, Price CL, Mann ER, Gellatly NL, Al-Hassi HO, Knight SC and Panoskaltsis N
Cancer Immunology Immunotherapy, Springer (Part of Springer Nature)
13-10-2020
Microenvironmental Hypoxia Induces Dynamic Changes in Lung Cancer Synthesis and Secretion of Extracellular VesiclesTse SW, Tan CF, Park JE, Gnanasekaran J, Gupta N, Low JK, Yeoh KW, Chng WJ, Tay CY, McCarthy NE, Lim SK and Sze SK
Cancers, Mdpi vol. 12 (10)
11-10-2020
Immune reconstitution and clinical recovery following anti-CD28 antibody (TGN1412)-induced cytokine stormPanoskaltsis N, McCarthy NE, Stagg AJ, Mummery CJ, Husni M, Arebi N, Greenstein D, Price CL, Al-Hassi HO, Koutinas M, Mantalaris A and Knight SC
Cancer Immunology, Immunotherapy, Springer Nature vol. 70 (4), 1127-1142.
08-10-2020
Myelopoiesis of acute inflammation: lessons from TGN1412-induced cytokine stormPanoskaltsis N, McCarthy NE and Knight SC
Cancer Immunology, Immunotherapy, Springer Nature vol. 70 (4), 1155-1160.
30-08-2020
Pulsed SILAM Reveals In Vivo Dynamics of Murine Brain Protein TranslationNg SS, Park JE, Meng W, Chen CP, Kalaria RN, McCarthy NE and Sze SK
Acs Omega, American Chemical Society (Acs) vol. 5 (23), 13528-13540.
20-05-2020
2019
CD4 T cells in hepatitis B virus: You don't have to be cytotoxic to work here and help.Gill US and McCarthy NE
Journal of Hepatology, Elsevier
08-11-2019
ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancerGupta N, Park JE, Tse W, Low JK, Kon OL, McCarthy N and Sze SK
Oncotarget, Impact Journals vol. 10 (57), 5970-5982.
15-10-2019
Effects of Low-FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease in a Randomized TrialCox SR, Lindsay JO, Fromentin S, Stagg AJ, McCarthy NE, Galleron N, Ibraim SB, Roume H, Levenez F, Pons N, Maziers N, Lomer MC, Ehrlich SD, Irving PM and Whelan K
Gastroenterology, Elsevier
02-10-2019
2018
Human γδ T-Cell Control of Mucosal Immunity and Inflammation.McCarthy NE and Eberl M
Front Immunol, Frontiers Media S.a. vol. 9, 985-985.
07-05-2018
902 - Low Fodmap Diet Improves Functional-Like Gastrointestinal Symptoms but Reduces Bifidobacteria and Faecalibacterium Prausnitzii in Quiescent Inflammatory Bowel Disease: A Randomised Controlled Trial and Metagenomic AnalysisCox SR, Stagg AJ, Fromentin S, Ehrlich SD, McCarthy NE, Galleron N, Levenez F, Lomer M, Lindsay JO, Irving PM and Whelan K
Gastroenterology, Elsevier vol. 154 (6), s-177.
01-05-2018
DOP017 Increased intestinal aryl hydrocarbon receptor expression and pathway sensitivity in Crohn’s diseaseHarrow P, McCarthy N, Stagg A and Lindsay J
Journal of Crohn's and Colitis, Oxford University Press (Oup) vol. 12 (supplement_1), s41-s41.
16-01-2018
DOP086 Low FODMAP diet improves functional-like gastrointestinal symptoms but reduces bifidobacteria and faecalibacterium prausnitzii in Quiescent inflammatory bowel disease: a randomised controlled trial and metagenomic analysisCox S, Stagg A, Fromentin S, Ehrlich D, McCarthy N, Galleron N, Levenez F, Lomer M, Lindsay J, Irving P and Whelan K
Journal of Crohn's and Colitis, Oxford University Press (Oup) vol. 12 (supplement_1), s87-s87.
16-01-2018
2017
Antigen-presenting human γδ T-cells promote intestinal CD4+ T-cell expression of IL-22 and mucosal release of calprotectinMCCARTHY NE, Tyler CJ, Lindsay JO, Stagg AJ, Moser B and Eberl M
Journal of Immunology, American Association of Immunologists
22-03-2017
2016
Regulation of human intestinal T-cell responses by type 1 interferon-STAT1 signaling is disrupted in inflammatory bowel diseaseGiles EM, Sanders TJ, McCarthy NE, Lung J, Pathak M, MacDonald TT, Lindsay JO and Stagg AJ
Mucosal Immunology, Elsevier vol. 10 (1), 184-193.
25-05-2016
MicroRNAs hsa-miR-99b, hsa-miR-330, hsa-miR-126 and hsa-miR-30c: Potential Diagnostic Biomarkers in Natural Killer (NK) Cells of Patients with Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalomyelitis (ME)Petty RD, McCarthy NE, Le Dieu R and Kerr JR
Plos One, Public Library of Science (Plos) vol. 11 (3)
11-03-2016
2015
Azathioprine therapy selectively ablates human Vδ2+ T cells in Crohn’s diseaseMcCarthy NE, Hedin CR, Sanders TJ, Amon P, Hoti I, Ayada I, Baji V, Giles EM, Wildemann M, Bashir Z, Whelan K, Sanderson I, Lindsay JO and Stagg AJ
Journal of Clinical Investigation, American Society For Clinical Investigation vol. 125 (8), 3215-3225.
13-07-2015
Respiratory tract dendritic cells in paediatric asthma.Brugha R, Mushtaq N, McCarthy NE, Stagg AJ and Grigg J
Clin Exp Allergy vol. 45 (3), 624-631.
01-03-2015
2014
Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn's disease.Sanders TJ, McCarthy NE, Giles EM, Davidson KLM, Haltalli MLR, Hazell S, Lindsay JO and Stagg AJ
Gastroenterology vol. 146 (5)
01-05-2014
Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblingsHedin CR, McCarthy NE, Louis P, Farquharson FM, McCartney S, Taylor K, Prescott NJ, Murrells T, Stagg AJ, Whelan K and Lindsay JO
Gut
07-01-2014
2013
Proinflammatory Vδ2+ T cells populate the human intestinal mucosa and enhance IFN-γ production by colonic αβ T cells.McCarthy NE, Bashir Z, Vossenkämper A, Hedin CR, Giles EM, Bhattacharjee S, Brown SG, Sanders TJ, Whelan K, MacDonald TT, Lindsay JO and Stagg AJ
J Immunol vol. 191 (5), 2752-2763.
01-09-2013
260 Siblings of Patients With Crohn's Disease Have a Distinct Microbiological and Immune Phenotype Compared to Healthy Controls: Insights Into Disease PathogenesisHedin C, McCarthy NE, Louis P, Farquharson F, McCartney S, Taylor K, Prescott NJ, Murrells T, Stagg AJ, Whelan K and Lindsay JO
Gastroenterology, Elsevier vol. 144 (5)
01-05-2013
2012
Skin- and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease.Mann ER, McCarthy NE, Peake STC, Milestone AN, Al-Hassi HO, Bernardo D, Tee CT, Landy J, Pitcher MC, Cochrane SA, Hart AL, Stagg AJ and Knight SC
Clin Exp Immunol vol. 170 (2), 122-130.
01-11-2012
Human gut-specific homeostatic dendritic cells are generated from blood precursors by the gut microenvironment.Mann ER, Bernardo D, Al-Hassi HO, English NR, Clark SK, McCarthy NE, Milestone AN, Cochrane SA, Hart AL, Stagg AJ and Knight SC
Inflamm Bowel Dis vol. 18 (7), 1275-1286.
01-07-2012
Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiotaBenjamin JL, Hedin CRH, Koutsoumpas A, Ng SC, McCarthy NE, Prescott NJ, Pessoa-Lopes P, Mathew CG, Sanderson J, Hart AL, Kamm MA, Knight SC, Forbes A, Stagg AJ, Lindsay JO and Whelan K
Inflammatory Bowel Diseases vol. 18 (6), 1092-1100.
01-01-2012
2011
Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease.Ng SC, Benjamin JL, McCarthy NE, Hedin CRH, Koutsoumpas A, Plamondon S, Price CL, Hart AL, Kamm MA, Forbes A, Knight SC, Lindsay JO, Whelan K and Stagg AJ
Inflamm Bowel Dis vol. 17 (10), 2027-2037.
01-10-2011
Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease.Benjamin JL, Hedin CRH, Koutsoumpas A, Ng SC, McCarthy NE, Hart AL, Kamm MA, Sanderson JD, Knight SC, Forbes A, Stagg AJ, Whelan K and Lindsay JO
Gut vol. 60 (7), 923-929.
01-07-2011
Expansion of Vδ2+T-Cells Occurs in Crohn's Disease Patients and Their Siblings: Impact of Therapy and Implications for PathogenesisHedin CR, McCarthy NE, Bhattacharjee S, James G, Whelan K, Lindsay JO and Stagg AJ
Gastroenterology, Elsevier vol. 140 (5), s-489.
01-05-2011
2010
W1813 Human Dendritic Cell Migration Markers and Function Determine T-Cell Migration Patterns and PropertiesMann ER, Ordiz DB, Al-Hassi HO, Clark SK, McCarthy NE, Milestone AN, Cochrane SA, Hart A, Stagg AJ and Knight SC
Gastroenterology, Elsevier vol. 138 (5), s-745.
01-05-2010
2009
S1700 The Role of Human γδ T-Cells in Inflammatory Bowel DiseaseMann ER, McCarthy NE, Milestone AN, Cochrane SA, Stagg AJ, Hart A and Knight SC
Gastroenterology, Elsevier vol. 136 (5), a-252.
01-05-2009
M1677 Imprinting of Lymphocyte Homing to Skin and Gut By Human Tissue DCMann ER, Al-Hassi HO, Clark SK, McCarthy NE, Cochrane SA, Hart A, Stagg AJ and Knight SC
Gastroenterology, Elsevier vol. 136 (5), a-408.
01-05-2009
S1750 Distinct Cytokine Patterns from Multiplex Profiles of Patients with Inflammatory Bowel Disease, Functional Bowel Disorder and Healthy ControlsNg SC, McCarthy NE, Plamondon S, Kamm MA, Stagg AJ and Knight SC
Gastroenterology, Elsevier vol. 136 (5), a-262.
01-05-2009
P309 - Altered imprinting of lymphocyte homing by colonic dendritic cells in human ulcerative colitisNg SC, Rigby R, Hart AL, Plamondon S, Gellatly N, McCarthy NE, Al-Hassi HO, Kamm MA, Knight SC and Stagg AJ
Journal of Crohn's and Colitis, Oxford University Press (Oup) vol. 3 (1), s132-s132.
01-02-2009
P316 - TNF-α production and differential release of Th1/Th2 cytokines detected in colonic tissues of inflammatory bowel disease patients but not controlsNg SC, McCarthy NE, Plamondon S, Kamm MA, Stagg AJ and Knight SC
Journal of Crohn's and Colitis, Oxford University Press (Oup) vol. 3 (1), s134-s135.
01-02-2009
2008
Dendritic cells from control but not atopic donors respond to contact and respiratory sensitizer treatment in vitro with differential cytokine production and altered stimulatory capacity.Holden NJ, Bedford PA, McCarthy NE, Marks NA, Ind PW, Jowsey IR, Basketter DA and Knight SC
Clin Exp Allergy vol. 38 (7), 1148-1159.
01-07-2008
W1201 Production of IL-10 By Colonic Dendritic Cells Is Associated with Higher Concentrations of Faecal Microbiota in Patients with Active Crohn's DiseaseNg SC, Koutsoumpas A, Hedin CR, McCarthy NE, Plamondon S, Kamm MA, Knight SC, Forbes A, Lindsay JO, Whelan K and Stagg AJ
Gastroenterology, Elsevier vol. 134 (4)
01-04-2008
P302 PRODUCTION OF IL-10 BY COLONIC DENDRITIC CELLS IS ASSOCIATED WITH HIGHER CONCENTRATIONS OF FAECAL MICROBIOTA IN PATIENTS WITH ACTIVE CROHN'S DISEASENg SC, Koutsoumpas A, Hedin CRH, McCarthy N, Plamondon S, Kamm MA, Knight SC, Forbes A, Lindsay JO, Whelan K and Stagg AJ
Journal of Crohn's and Colitis, Oxford University Press (Oup) vol. 2 (1)
01-02-2008
2007
Inhaled allergen-driven CD1c up-regulation and enhanced antigen uptake by activated human respiratory-tract dendritic cells in atopic asthma.McCarthy NE, Jones HA, Marks NA, Shiner RJ, Ind PW, Al-Hassi HO, English NR, Murray CM, Lambert JR, Knight SC and Stagg AJ
Clin Exp Allergy vol. 37 (1), 72-82.
01-01-2007
Grants
Evaluating the anti-fungal activity of TCB008 cell therapyNeil McCarthy
£20,000 TC BioPharm
01-04-2023 - 30-09-2023
Assessing gut macrophage damage by intestinal fungi in inflammatory bowel disease (IBD)Neil McCarthy
£7,000 Barts and the London Charity
22-09-2022 - 21-09-2023
Investigating BTN2A/3A function in inflammatory bowel diseaseNeil McCarthy
£316,434 ImCheck Therapeutics SAS
02-03-2020 - 31-03-2023
Human tissue-resident immunity to intestinal fungiNeil McCarthy
£153,432 Barts and the London Charity
30-09-2019 - 30-06-2023
Fungal suppression by human gut Vdelta2 T-cells in mucosal immunity and inflammationNeil McCarthy
£556,418 MRC Medical Research Council
02-01-2018 - 30-06-2023