Dr Oscar Maiques

Oscar Maiques

Lecturer / Group Leader

Barts Cancer Insitute/ Cancer Biomarkers and Biotherapeutics
Queen Mary University of London

Research

extracellular matrix, digital pathology, spatial biology, multiplex imaging, mechanobiology, multiomics

Interests

I am interested in in vitro models that manipulate ECM organization in 3D
Tools to measure stiffness or viscolastic properties of this materials would be important too

Publications

solid heart iconPublications of specific relevance to Predictive <em>in vitro</em> Models

2025

Pan-cancer drivers of metastasis
Lusby R, Demirdizen E, Inayatullah M, Kundu P, Maiques O, Zhang Z, Terp MG, Sanz-Moreno V and Tiwari VK
Molecular Cancer, Springer Nature vol. 24 (1) 
02-01-2025

2024

Corrigendum to “Early functional mismatch between breast cancer cells and their tumour microenvironment suppresses long term growth” [Cancer Lett. 544 (2022), 215800]
Perdrix Rosell A, Maiques O, Martin JAJ, Chakravarty P, Ombrato L, Sanz-Moreno V and Malanchi I
Cancer Letters, Elsevier vol. 597 
01-07-2024
A systematic pan-cancer study on deep learning-based prediction of multi-omic biomarkers from routine pathology images
Arslan S, Schmidt J, Bass C, Mehrotra D, Geraldes A, Singhal S, Hense J, Li X, Raharja-Liu P, Maiques O, Kather JN and Pandya P
Communications Medicine, Springer Nature vol. 4 (1) 
15-03-2024

2023

CD73 controls Myosin II–driven invasion, metastasis, and immunosuppression in amoeboid pancreatic cancer cells
Samain R, Maiques O, Monger J, Lam H, Candido J, George S, Ferrari N, KohIhammer L, Lunetto S, Varela A, Orgaz JL, Vilardell F, Olsina JJ, Matias-Guiu X, Sarker D, Biddle A, Balkwill FR, Eyles J, Wilkinson RW, Kocher HM, Calvo F, Wells CM and Sanz-Moreno V
Science Advances, American Association For The Advancement of Science (Aaas) vol. 9 (42) 
18-10-2023
AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration
Crosas-Molist E, Graziani V, Maiques O, Pandya P, Monger J, Samain R, George SL, Malik S, Salise J, Morales V, Le Guennec A, Atkinson RA, Marti RM, Matias-Guiu X, Charras G, Conte MR, Elosegui-Artola A, Holt M and Sanz-Moreno V
Nature Communications, Springer Nature vol. 14 (1) 
22-05-2023
LAP1 supports nuclear adaptability during constrained melanoma cell migration and invasion
Jung-Garcia Y, Maiques O, Monger J, Rodriguez-Hernandez I, Fanshawe B, Domart M-C, Renshaw MJ, Marti RM, Matias-Guiu X, Collinson LM, Sanz-Moreno V and Carlton JG
Nature Cell Biology, Springer Nature vol. 25 (1), 108-119.  
01-01-2023

2022

Multiplex chromogenic immunohistochemistry to stain and analyze paraffin tissue sections from the mouse or human
Maiques O and Sanz-Moreno V
Star Protocols, Elsevier vol. 3 (4) 
01-12-2022
Early functional mismatch between breast cancer cells and their tumour microenvironment suppresses long term growth
Perdrix Rosell A, Maiques O, Martin JAJ, Chakravarty P, Ombrato L, Sanz-Moreno V and Malanchi I
Cancer Letters, Elsevier vol. 544 
06-07-2022
M-CSF as a therapeutic target in BRAFV600E melanoma resistant to BRAF inhibitors
Barceló C, Sisó P, de la Rosa I, Megino-Luque C, Navaridas R, Maiques O, Urdanibia I, Eritja N, Soria X, Potrony M, Calbet-Llopart N, Puig S, Matías-Guiu X, Martí RM and Macià A
British Journal of Cancer, Springer Nature vol. 127 (6), 1142-1152.  
20-06-2022
Suppression of endothelial cell FAK expression reduces pancreatic ductal adenocarcinoma metastasis after gemcitabine treatmentEC FAK regulates gemcitabine treated liver metastasis
Roy-Luzarraga M, Reynolds LE, de Luxán-Delgado B, Maiques O, Wisniewski L, Newport E, Rajeeve V, Drake RJG, Gómez-Escudero J, Richards FM, Weller C, Dormann C, Meng Y-M, Vermeulen PB, Saur D, Sanz-Moreno V, Wong P-P, Géraud C, Cutillas PR and Hodivala-Dilke K
Cancer Research, American Association For Cancer Research (Aacr) vol. 82 (10), 1909-1925.  
29-03-2022

2021

Differential Immunoexpression of BRAF/V600E, Senescence Markers, PTEN, and T-type Calcium Channels in Acquired Naevi According to their Histopathological and Dermoscopic Classification
MORENO S, MAIQUES O, BARCELO C, ROMERO M, SANTACANA M, GOMEZ I, CUEVAS D, VELASCO A, Alvar V, MACIA A, Ramon B, VALLS J, GATIUS S, CANTI C, MATIAS-GUIU X, SORIA X and MARTI RM
Acta Dermato Venereologica, Mjs Publishing, Medical Journals Sweden Ab vol. 101 (11) 
24-11-2021
The amoeboid state as part of the epithelial-to-mesenchymal transition programme
Graziani V, Rodriguez-Hernandez I, Maiques O and Sanz-Moreno V
Trends in Cell Biology, Elsevier vol. 32 (3), 228-242.  
23-11-2021
BRAFV600E Mutant Allele Frequency (MAF) Influences Melanoma Clinicopathologic Characteristics
Soria X, Vilardell F, Maiques Ó, Barceló C, Sisó P, de la Rosa I, Velasco A, Cuevas D, Santacana M, Gatius S, Matías-Guiu X, Rodrigo A, Macià A and Martí RM
Cancers, Mdpi vol. 13 (20) 
11-10-2021
Rho GTPase signaling in cancer progression and dissemination
Crosas-Molist E, Samain R, Kohlhammer L, Orgaz JL, George SL, Maiques O, Barcelo J and Sanz-Moreno V
Physiological Reviews, American Physiological Society vol. 102 (1), 455-510.  
20-09-2021
Kallikrein-Related Peptidase 6 Is Associated with the Tumour Microenvironment of Pancreatic Ductal Adenocarcinoma
Candido JB, Maiques O, Boxberg M, Kast V, Peerani E, Tomás-Bort E, Weichert W, Sananes A, Papo N, Magdolen V, Sanz-Moreno V and Loessner D
Cancers, Mdpi vol. 13 (16) 
05-08-2021
Location, location, location: Melanoma cells “living at the edge”
Maiques O and Sanz‐Moreno V
Experimental Dermatology, Wiley vol. 31 (1), 82-88.  
05-07-2021
A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma
Maiques O, Fanshawe B, Crosas-Molist E, Rodriguez-Hernandez I, Volpe A, Cantelli G, Boehme L, Orgaz JL, Mardakheh FK, Sanz-Moreno V and Fruhwirth GO
British Journal of Cancer, Springer Nature vol. 125 (5), 699-713.  
25-06-2021

2020

WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion
Rodriguez-Hernandez I, Maiques O, Kohlhammer L, Cantelli G, Perdrix-Rosell A, Monger J, Fanshawe B, Bridgeman VL, Karagiannis SN, Penin RM, Marcolval J, Marti RM, Matias-Guiu X, Fruhwirth GO, Orgaz JL, Malanchi I and Sanz-Moreno V
Nature Communications, Springer Nature vol. 11 (1) 
20-10-2020
First-in-Human Study of AT13148, a Dual ROCK-AKT Inhibitor in Patients with Solid Tumors
McLeod R, Kumar R, Papadatos-Pastos D, Mateo J, Brown JS, Garces AHI, Ruddle R, Decordova S, Jueliger S, Ferraldeschi R, Maiques O, Sanz-Moreno V, Jones P, Traub S, Halbert G, Mellor S, Swales KE, Raynaud FI, Garrett MD and Banerji U
Clinical Cancer Research, American Association For Cancer Research (Aacr) vol. 26 (18), 4777-4784.  
15-09-2020
Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells
Wong P-P, Muñoz-Félix JM, Hijazi M, Kim H, Robinson SD, De Luxán-Delgado B, Rodríguez-Hernández I, Maiques O, Meng Y-M, Meng Q, Bodrug N, Dukinfield MS, Reynolds LE, Elia G, Clear A, Harwood C, Wang Y, Campbell JJ, Singh R, Zhang P, Schall TJ, Matchett KP, Henderson NC, Szlosarek PW, Dreger SA, Smith S, Jones JL, Gribben JG, Cutillas PR and Meier P
Cell, Elsevier vol. 181 (6), 1346-1363.e21.  
29-05-2020
T-Type Calcium Channels: A Potential Novel Target in Melanoma
Barceló C, Sisó P, Maiques O, de la Rosa I, Martí RM and Macià A
Cancers, Mdpi vol. 12 (2) 
08-02-2020
Descriptive study of naevus involution in a series of 74 patients with atypical naevus syndrome under SIAscopy digital follow‐up
Moreno S, Maiques O, Gatius S, Veà A, Barrera J, Barcelo C, Santacana M, Soria X, Matias‐Guiu X and Martí RM
Journal of The European Academy of Dermatology and Venereology, Wiley vol. 34 (6), 1210-1217.  
06-02-2020
Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance
Orgaz JL, Crosas-Molist E, Sadok A, Perdrix-Rosell A, Maiques O, Rodriguez-Hernandez I, Monger J, Mele S, Georgouli M, Bridgeman V, Karagiannis P, Lee R, Pandya P, Boehme L, Wallberg F, Tape C, Karagiannis SN, Malanchi I and Sanz-Moreno V
Cancer Cell, Elsevier vol. 37 (1), 85-103.e9.  
01-01-2020

2019

T-Type Calcium Channels as Potential Therapeutic Targets in Vemurafenib-Resistant BRAFV600E Melanoma
Barceló C, Sisó P, Maiques O, García-Mulero S, Sanz-Pamplona R, Navaridas R, Megino C, Felip I, Urdanibia I, Eritja N, Soria X, Piulats JM, Penin RM, Dolcet X, Matías-Guiu X, Martí RM and Macià A
Journal of Investigative Dermatology, Elsevier vol. 140 (6), 1253-1265.  
23-12-2019
Recent advances in tissue imaging for cancer research
Maiques O, Georgouli M and Sanz-Moreno V
F1000research, F1000research vol. 8 
25-11-2019
Repurposing an anti‐cancer agent for the treatment of hypertrophic heart disease
Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J, Bedi KC, Margulies KB, Sanz‐Moreno V, Hobbs A and Hodivala‐Dilke K
The Journal of Pathology, Wiley vol. 249 (4), 523-535.  
30-10-2019
Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-β-induced epithelial to amoeboid transition
López-Luque J, Bertran E, Crosas-Molist E, Maiques O, Malfettone A, Caja L, Serrano T, Ramos E, Sanz-Moreno V and Fabregat I
Cancer Letters, Elsevier vol. 464, 15-24.  
26-08-2019
In vitro Cell Migration, Invasion, and Adhesion Assays: From Cell Imaging to Data Analysis
Pijuan J, Barceló C, Moreno DF, Maiques O, Sisó P, Marti RM, Macià A and Panosa A
Frontiers in Cell and Developmental Biology, Frontiers vol. 7 
14-06-2019
T-type Cav3.1 channels mediate progression and chemotherapeutic resistance in glioblastoma
Visa A, Sallán MC, Maiques O, Alza L, Talavera E, López-Ortega R, Santacana M, Herreros J and Cantí C
Cancer Research, American Association For Cancer Research (Aacr) vol. 79 (8) 
15-04-2019
Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment
Georgouli M, Herraiz C, Crosas-Molist E, Fanshawe B, Maiques O, Perdrix A, Pandya P, Rodriguez-Hernandez I, Ilieva KM, Cantelli G, Karagiannis P, Mele S, Lam H, Josephs DH, Matias-Guiu X, Marti RM, Nestle FO, Orgaz JL, Malanchi I, Fruhwirth GO, Karagiannis SN and Sanz-Moreno V
Cell, Elsevier vol. 176 (4), 757-774.e23.  
31-01-2019

2018

Tumor suppressive function of E2F‐1 on PTEN‐induced serrated colorectal carcinogenesis
Dosil MA, Navaridas R, Mirantes C, Tarragona J, Eritja N, Felip I, Urdanibia I, Megino C, Domingo M, Santacana M, Gatius S, Piñol C, Barceló C, Maiques O, Macià A, Velasco A, Vaquero M, Matias‐Guiu X and Dolcet X
The Journal of Pathology, Wiley vol. 247 (1), 72-85.  
27-11-2018
T‐type calcium channels drive migration/invasion in BRAFV600E melanoma cells through Snail1
Maiques O, Barceló C, Panosa A, Pijuan J, Orgaz JL, Rodriguez‐Hernandez I, Matas‐Nadal C, Tell G, Vilella R, Fabra A, Puig S, Sanz‐Moreno V, Matias‐Guiu X, Canti C, Herreros J, Marti RM and Macià A
Pigment Cell & Melanoma Research, Wiley vol. 31 (4), 484-495.  
18-02-2018

2017

Immunohistochemical analysis of T‐type calcium channels in acquired melanocytic naevi and melanoma
Maiques O, Macià A, Moreno S, Barceló C, Santacana M, Vea A, Herreros J, Gatius S, Ortega E, Valls J, Chen BJ, Llobet‐Navas D, Matias‐Guiu X, Cantí C and Marti RM
British Journal of Dermatology, Oxford University Press (Oup) vol. 176 (5), 1247-1258.  
20-03-2017

2016

2‐phenylethynesulphonamide (PFT‐μ) enhances the anticancer effect of the novel hsp90 inhibitor NVP‐AUY922 in melanoma, by reducing GSH levels
Yeramian A, Vea A, Benítez S, Ribera J, Domingo M, Santacana M, Martinez M, Maiques O, Valls J, Dolcet X, Vilella R, Cabiscol E, Matias-Guiu X and Marti RM
Pigment Cell & Melanoma Research, Wiley vol. 29 (3), 352-371.  
21-04-2016

2015

TGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination
Cantelli G, Orgaz JL, Rodriguez-Hernandez I, Karagiannis P, Maiques O, Matias-Guiu X, Nestle FO, Marti RM, Karagiannis SN and Sanz-Moreno V
Current Biology, Elsevier vol. 25 (22), 2899-2914.  
29-10-2015

2014

Modeling glands with PTEN deficient cells and microscopic methods for assessing PTEN loss: Endometrial cancer as a model
Eritja N, Santacana M, Maiques O, Gonzalez-Tallada X, Dolcet X and Matias-Guiu X
Methods, Elsevier vol. 77, 31-40.  
18-11-2014
A 9-protein biomarker molecular signature for predicting histologic type in endometrial carcinoma by immunohistochemistry
Santacana M, Maiques O, Valls J, Gatius S, Abó AI, López-García MÁ, Mota A, Reventós J, Moreno-Bueno G, Palacios J, Bartosch C, Dolcet X and Matias-Guiu X
Human Pathology, Elsevier vol. 45 (12), 2394-2403.  
23-08-2014
FISH analysis of PTEN in endometrial carcinoma. comparison with SNP arrays and MLPA
Maiques O, Cuevas D, Dios DAG, Coenegrachts L, Santacana M, Velasco A, Romero M, Gatius S, Lambrechts D, Müller S, Pedersen HC, Dolcet X, Amant F and Matias-Guiu X
Histopathology, Wiley vol. 65 (3), 371-388.  
23-04-2014

2013

Optimal protocol for PTEN immunostaining; role of analytical and preanalytical variables in PTEN staining in normal and neoplastic endometrial, breast, and prostatic tissues
Maiques O, Santacana M, Valls J, Pallares J, Mirantes C, Gatius S, Dios DAG, Amant F, Pedersen HC, Dolcet X and Matias-Guiu X
Human Pathology, Elsevier vol. 45 (3), 522-532.  
07-11-2013
An inducible knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias
Mirantes C, Eritja N, Dosil MA, Santacana M, Pallares J, Gatius S, Bergadà L, Maiques O, Matias-Guiu X and Dolcet X
Disease Models & Mechanisms, The Company of Biologists vol. 6 (3), 710-720.  
01-01-2013

2012

Gene expression microarray-based assay to determine tumor site of origin in a series of metastatic tumors to the ovary and peritoneal carcinomatosis of suspected gynecologic origin
Azueta A, Maiques O, Velasco A, Santacana M, Pallares J, Novell A, Llombart-Cussac A, Gonzalez-Tallada X, Mozos A, Prat J, Pillai R, Mata M and Matias-Guiu X
Human Pathology, Elsevier vol. 44 (1), 20-28.  
30-08-2012