Dr Oliver Pearce
Reader in Tumour Extracellular Matrix
Centre for Tumour Microenvironment
Barts Cancer Institute
Barts Cancer Institute
Research
Extracellular matrix, Immunity, decellularised tissue models
Interests
We make decellularised models from human cancer tissues to explore how the tumour immune infiltrate is orientated and activated by the extracellular matrix. I run a service providing access to decellularised models and associated assays. www.matrixdynamics.co.ukPublications
Publications of specific relevance to Predictive in vitro Models2024
Tarantola L, Keklikoglou I and Pearce OM (2024). Abstract C045: The extracellular matrix glycoprotein periostin supports chemotherapy resistance by modulating macrophage recruitment and phagocytosis in triple negative breast cancer. American Association for Cancer Research (AACR) Cancer Research vol. 84, (22_Supplement) c045-c045. Tyler EJ and Pearce OMT (2024). Tumor's Digest: Macrophage Metabolism Creates a Barrier to T Cells. American Association for Cancer Research (AACR) Cancer Research vol. 84, (20) 3322-3323. Hirani P, McDermott J, Rajeeve V, Cutillas PR, Jones JL, Pennington DJ, Wight TN, Santamaria S, Alonge KM and Pearce OMT (2024). Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate. American Association for Cancer Research (AACR) Cancer Research Communications vol. 4, (4) 970-985. 
Liu Y, Okesola BO, de la Peña DO, Li W, Lin M, Trabulo S, Tatari M, Lawlor RT, Scarpa A, Wang W, Knight M, Loessner D, Heeschen C, Mata A and Pearce OMT (2024). A Self‐Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer. Wiley Advanced Healthcare Materials vol. 13, (17) 2023
Verbruggen SW, Nolan J, Duffy MP, Pearce OMT, Jacobs CR and Knight MM (2023). A Novel Primary Cilium‐Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells. Wiley Advanced Science vol. 11, (2) 2305842-2305842. Carter EP, Yoneten KK, Gavara N, Tyler EJ, Gauthier V, Murray ER, Dijke PT, Cameron AJ, Pearce O and Grose RP (2023). Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function. Wiley The Journal of Pathology vol. 262, (1) 90-104. Carter E, Yoneten K, Gavara N, Tyler E, Gauthier V, Murray E, Dijke PT, Cameron A, Pearce O and Grose R (2023). Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function. Elsevier Pancreatology vol. 23, (4) e13-e14. Puttock EH, Tyler EJ, Manni M, Maniati E, Butterworth C, Burger Ramos M, Peerani E, Hirani P, Gauthier V, Liu Y, Maniscalco G, Rajeeve V, Cutillas P, Trevisan C, Pozzobon M, Lockley M, Rastrick J, Läubli H, White A and Pearce OMT (2023). Extracellular matrix educates an immunoregulatory tumor macrophage phenotype found in ovarian cancer metastasis. Springer Nature Nature Communications vol. 14, (1) Hirani P, Alonge KM, Pennington DJ, Cutillas PR, Wight TN and Pearce OM (2023). Abstract 5841: Exploring the role of versican in immune exclusion within triple negative breast cancer. American Association for Cancer Research (AACR) Cancer Research vol. 83, (7_Supplement) 5841-5841. Gauthier V, Tyler E, Liu Y, Sharp TV and Pearce OM (2023). Abstract 1339: Targeting specific extracellular matrix proteins to reactivate T cell trafficking in triple-negative breast cancer. American Association for Cancer Research (AACR) Cancer Research vol. 83, (7_Supplement) 1339-1339. Nolan J, Pearce OMT, Screen HRC, Knight MM and Verbruggen SW (2023). Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK. MDPI Cancers vol. 15, (3) 2022
Meng H, Fu S, Ferreira MB, Hou Y, Pearce OM, Gavara N and Knight MM (2022). YAP activation inhibits inflammatory signalling and cartilage breakdown associated with reduced primary cilia expression. Elsevier Osteoarthritis and Cartilage vol. 31, (5) 600-612. Stanczak MA, Rodrigues Mantuano N, Kirchhammer N, Sanin DE, Jacob F, Coelho R, Everest-Dass AV, Wang J, Trefny MP, Monaco G, Bärenwaldt A, Gray MA, Petrone A, Kashyap AS, Glatz K, Kasenda B, Normington K, Broderick J, Peng L, Pearce OMT, Pearce EL, Bertozzi CR, Zippelius A and Läubli H (2022). Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade. American Association for the Advancement of Science (AAAS) Science Translational Medicine vol. 14, (669) eabj1270-eabj1270. Beatson R, Läubli H, Pearce OMT and Reis CA (2022). Editorial: Glycans: Masters of immunity, from cancers to inflammatory disease. Frontiers Frontiers in Immunology vol. 13, Sarmin AM, Moussaid NE, Suntornnond R, Tyler EJ, Kim Y-H, Di Cio S, Megone WV, Pearce O, Gautrot JE, Dawson J and Connelly JT (2022). Multi-Scale Analysis of the Composition, Structure, and Function of Decellularized Extracellular Matrix for Human Skin and Wound Healing Models. MDPI Biomolecules vol. 12, (6) Malacrida B, Pearce OMT and Balkwill FR (2022). Building in vitro 3D human multicellular models of high-grade serous ovarian cancer. Elsevier STAR Protocols vol. 3, (1) Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A, Marshall JJT, Rosewell I, Tatari M, Rajeeve V, Khan F, Wang J, Kotantaki P, Tyler EJ, Singh N, Reader CS, Carter EP, Hodivala-Dilke K, Grose RP, Kocher HM, Gavara N, Pearce O, Cutillas P, Marshall JF and Cameron AJM (2022). Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion. Elsevier Cell Reports vol. 38, (4) 2021
Lecker LSM, Berlato C, Maniati E, Delaine-Smith R, Pearce OMT, Heath O, Nichols SJ, Trevisan C, Novak M, McDermott J, Brenton JD, Cutillas PR, Rajeeve V, Hennino A, Drapkin R, Loessner D and Balkwill FR (2021). TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian CancerTGFBI and Ovarian Cancer. American Association for Cancer Research (AACR) Cancer Research vol. 81, (22) 5706-5719. Hirani P, Gauthier V, Allen CE, Wight TN and Pearce OMT (2021). Targeting Versican as a Potential Immunotherapeutic Strategy in the Treatment of Cancer. Frontiers Frontiers in Oncology vol. 11, Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR and Knight MM (2021). Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype. MDPI Cancers vol. 13, (12) Malacrida B, Nichols S, Maniati E, Jones R, Delanie-Smith R, Roozitalab R, Tyler EJ, Thomas M, Boot G, Mackerodt J, Lockley M, Knight MM, Balkwill FR and Pearce OMT (2021). A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion. Elsevier iScience vol. 24, (6) Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker LSM, Pearce OMT, Knight MM and Balkwill FR (2021). Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer. Elsevier iScience vol. 24, (6) Delaine-Smith R, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones R, Lecker L, Pearce O, Knight M and Balkwill F (2021). Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer., Editors: Balkwill F. biorxiv.org Reuten R, Zendehroud S, Nicolau M, Fleischhauer L, Laitala A, Kiderlen S, Nikodemus D, Wullkopf L, Nielsen SR, McNeilly S, Prein C, Rafaeva M, Schoof EM, Furtwängler B, Porse BT, Kim H, Won KJ, Sudhop S, Zornhagen KW, Suhr F, Maniati E, Pearce OMT, Koch M, Oddershede LB, Van Agtmael T, Madsen CD, Mayorca-Guiliani AE, Bloch W, Netz RR and Clausen-Schaumann H (2021). Basement membrane stiffness determines metastases formation. Springer Nature Nature Materials vol. 20, (6) 892-903. 2020
Pearce OMT and Läubli H (2020). A Sweet Approach to Heat Up Cancer Response to Immunotherapy. American Association for Cancer Research (AACR) Cancer Discovery vol. 10, (12) 1789-1790. Zaghdoudi S, Decaup E, Belhabib I, Samain R, Cassant-Sourdy S, Rochotte J, Brunel A, Schlaepfer D, Cros J, Neuzillet C, Strehaiano M, Alard A, Tomasini R, Rajeeve V, Perraud A, Mathonnet M, Pearce OMT, Martineau Y, Pyronnet S, Bousquet C and Jean C (2020). FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer. EMBO MOLECULAR MEDICINE vol. 12, (11) Zaghdoudi S, Decaup E, Belhabib I, Samain R, Cassant‐Sourdy S, Rochotte J, Brunel A, Schlaepfer D, Cros J, Neuzillet C, Strehaiano M, Alard A, Tomasini R, Rajeeve V, Perraud A, Mathonnet M, Pearce OM, Martineau Y, Pyronnet S, Bousquet C and Jean C (2020). FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer. Springer Nature EMBO Molecular Medicine vol. 12, (11) Wight TN, Kang I, Evanko SP, Harten IA, Chang MY, Pearce OMT, Allen CE and Frevert CW (2020). Versican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation. Frontiers Media Frontiers in Immunology vol. 11, Maniati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C, Delaine-Smith RM, Pearce OMT, Hirani P, Joyce JD, Szabova L, Perets R, Sansom OJ, Drapkin R, Bailey P and Balkwill F (2020). Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment. Elsevier BV SSRN Electronic Journal 2018
Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR and Hynes RO (2018). Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. Journal of Proteome Research vol. 16, (8) 3083-3091. Pearce OMT and Läubli H (2018). Cancer Immunotherapy. Oxford University Press (OUP) Glycobiology vol. 28, (9) 638-639. Pearce OM (2018). Cancer glycan epitopes: biosynthesis, structure, and function. Glycobiology 2017
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones RR, Montfort A, Dowe T, Gribben J, Jones JL, Kocher HM, Serody JS, Vincent BG, Connelly J, Brenton JD, Chelala C, Cutillas PR, Lockley M, Bessant C, Knight M and Balkwill FR (2017). Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers. Cancer Discov Bergfeld AK, Lawrence R, Diaz SL, Pearce OMT, Ghaderi D, Gagneux P, Leakey MG and Varki A (2017). N-glycolyl groups of nonhuman chondroitin sulfates survive in ancient fossils. Proc Natl Acad Sci U S A vol. 114, (39) E8155-E8164. 2016
Montfort A, Pearce OMT, Maniati E, Vincent B, Bixby LM, Bo hm S, Dowe T, Wilkes EH, Chakravarty P, Thompson R, Topping J, Cutillas PR, Lockley M, Serody JS, Capasso M and Balkwill FR (2016). A strong B cell response is part of the immune landscape in human high-grade serous ovarian metastases. American Association for Cancer Research Clinical Cancer Research BALKWILL F, Anne Montfort and Oliver Pearce (2016). Neoadjuvant chemotherapy modulates the immune microenvironment in metastases of tubo-ovarian high-grade serous carcinoma. American Association for Cancer Research Clinical Cancer Research 2015
Pearce OMT and Läubli H (2015). Sialic acids in cancer biology and immunity. Oxford University Press (OUP) Glycobiology vol. 26, (2) 111-128. Gopinathan G, Milagre C, Pearce OMT, Reynolds LE, Hodivala-Dilke K, Leinster DA, Zhong H, Hollingsworth RE, Thompson R, Whiteford JR and Balkwill F (2015). Interleukin-6 Stimulates Defective Angiogenesis. American Association for Cancer Research (AACR) Cancer Research vol. 75, (15) 3098-3107. Gopinathan G, Milagre C, Pearce OMT, Reynolds L, Hodivala-Dilke K, Leinster A, Zhong H, Hollingsworth RE, Thompson R, Whiteford JR and Balkwill F (2015). Abstract 4162: Interleukin–6 stimulates defective angiogenesis. American Association for Cancer Research (AACR) Cancer Research vol. 75, (15_Supplement) 4162-4162. Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OMT, Kiso M, Miyagi T, Sawada M, Varki A, Kitajima K and Sato C (2015). Rapid Trimming of Cell Surface Polysialic Acid (PolySia) by Exovesicular Sialidase Triggers Release of Preexisting Surface Neurotrophin*. Elsevier Journal of Biological Chemistry vol. 290, (21) 13202-13214. Pearce OMT, Samraj AN, Läubli H, Varki NM and Varki A (2015). Reply to Mackenzie: A comparison of Neu5Gc and α-gal xenoantigens. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 112, (12) e1405-e1405. Schwarz F, Pearce OM, Wang X, Samraj AN, Läubli H, Garcia JO, Lin H, Fu X, Garcia-Bingman A, Secrest P, Romanoski CE, Heyser C, Glass CK, Hazen SL, Varki N, Varki A and Gagneux P (2015). Siglec receptors impact mammalian lifespan by modulating oxidative stress. eLife eLife vol. 4, 2014
Samraj AN, Pearce OMT, Läubli H, Crittenden AN, Bergfeld AK, Banda K, Gregg CJ, Bingman AE, Secrest P, Diaz SL, Varki NM and Varki A (2014). A red meat-derived glycan promotes inflammation and cancer progression. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 112, (2) 542-547. Läubli H, Pearce OMT, Schwarz F, Siddiqui SS, Deng L, Stanczak MA, Verhagen A, Secrest P, Lusk C, Schwartz AG, Varki NM, Bui JD and Varki A (2014). Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 111, (39) 14211-14216. Pearce OM, Läubli H, Bui J and Varki A (2014). Hormesis in cancer immunology. Taylor & Francis OncoImmunology vol. 3, (6) Pearce OMT, Läubli H, Verhagen A, Secrest P, Zhang J, Varki NM, Crocker PR, Bui JD and Varki A (2014). Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 111, (16) 5998-6003. Bergfeld A, Lawrence R, Diaz S, Pearce O, van Vleet J, Esko J, Choudhury B and Varki A (2014). Discovery of novel monosaccharides in animal glycans: natural occurrence of N‐glycolylhexosamines (607.6). Wiley The FASEB Journal vol. 28, (S1) 2013
Buchlis G, Odorizzi P, Soto PC, Pearce OMT, Hui DJ, Jordan MS, Varki A, Wherry EJ and High KA (2013). Enhanced T Cell Function in a Mouse Model of Human Glycosylation. The American Association of Immunologists The Journal of Immunology vol. 191, (1) 228-237. 2012
Bergfeld AK, Pearce OMT, Diaz SL, Pham T and Varki A (2012). Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups ELUCIDATING THE INTRACELLULAR FATE OF THE NON-HUMAN SIALIC ACID N-GLYCOLYLNEURAMINIC ACID*. Elsevier Journal of Biological Chemistry vol. 287, (34) 28865-28881. Davies LRL, Pearce OMT, Tessier MB, Assar S, Smutova V, Pajunen M, Sumida M, Sato C, Kitajima K, Finne J, Gagneux P, Pshezhetsky A, Woods R and Varki A (2012). Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups RESISTANCE OF α2–8-LINKED N-GLYCOLYLNEURAMINIC ACID TO ENZYMATIC CLEAVAGE*. Elsevier Journal of Biological Chemistry vol. 287, (34) 28917-28931. Bergfeld AK, Pearce OMT, Diaz SL, Lawrence R, Vocadlo DJ, Choudhury B, Esko JD and Varki A (2012). Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups INCORPORATION OF N-GLYCOLYLHEXOSAMINES INTO MAMMALIAN GLYCANS BY FEEDING N-GLYCOLYLGALACTOSAMINE*. Elsevier Journal of Biological Chemistry vol. 287, (34) 28898-28916. Davies L, Pearce O, Tessier M, Assar S, Smutova V, Pshezhetsky A, Woods R and Varki A (2012). Unusual chemical and enzymatic stability of polysialic acid containing N‐glycolylneuraminic acid. Wiley The FASEB Journal vol. 26, (S1) 610.1-610.1. 2010
Buchlis G, Mingozzi F, Soto PC, Pearce O, Hui DJ, Varki AP and High KA (2010). Intrinsically Hyperactive and Hyperproliferative CD8+ T Cells In Cmah-/- Mice as a Model of Human Gene Transfer Responses. American Society of Hematology Blood vol. 116, (21) Pearce OMT and Varki A (2010). Chemo-enzymatic synthesis of the carbohydrate antigen N-glycolylneuraminic acid from glucose. Elsevier Carbohydrate Research vol. 345, (9) 1225-1229. 2005
Pearce OMT, Fisher KD, Humphries J, Seymour LW, Smith A and Davis BG (2005). Glycoviruses: Chemical Glycosylation Retargets Adenoviral Gene Transfer. Wiley Angewandte Chemie International Edition vol. 44, (7) 1057-1061. Pearce OMT, Fisher KD, Humphries J, Seymour LW, Smith A and Davis BG (2005). Titelbild: Glycoviruses: Chemical Glycosylation Retargets Adenoviral Gene Transfer (Angew. Chem. 7/2005). Wiley Angewandte Chemie vol. 117, (7) 1005-1005. Pearce OMT, Fisher KD, Humphries J, Seymour LW, Smith A and Davis BG (2005). Cover Picture: Glycoviruses: Chemical Glycosylation Retargets Adenoviral Gene Transfer (Angew. Chem. Int. Ed. 7/2005). Wiley Angewandte Chemie International Edition vol. 44, (7) 983-983.