Abstract C045: The extracellular matrix glycoprotein periostin supports chemotherapy resistance by modulating macrophage recruitment and phagocytosis in triple negative breast cancer
Tarantola L, Keklikoglou I and Pearce OM
Cancer Research, American Association For Cancer Research (Aacr) vol. 84 (22_Supplement), c045-c045.  
17-11-2024

Tumor's Digest: Macrophage Metabolism Creates a Barrier to T Cells.
Tyler EJ and Pearce OMT
Cancer Research, American Association For Cancer Research (Aacr) vol. 84 (20), 3322-3323.  
26-08-2024

Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate
Hirani P, McDermott J, Rajeeve V, Cutillas PR, Jones JL, Pennington DJ, Wight TN, Santamaria S, Alonge KM and Pearce OMT
Cancer Research Communications, American Association For Cancer Research (Aacr) vol. 4 (4), 970-985.  
03-04-2024

Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function
Carter EP, Yoneten KK, Gavara N, Tyler EJ, Gauthier V, Murray ER, Dijke PT, Cameron AJ, Pearce O and Grose RP
The Journal of Pathology, Wiley vol. 262 (1), 90-104.  
06-11-2023

Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function
Carter E, Yoneten K, Gavara N, Tyler E, Gauthier V, Murray E, Dijke PT, Cameron A, Pearce O and Grose R
Pancreatology, Elsevier vol. 23 (4), e13-e14.  
01-06-2023

Extracellular matrix educates an immunoregulatory tumor macrophage phenotype found in ovarian cancer metastasis
Puttock EH, Tyler EJ, Manni M, Maniati E, Butterworth C, Burger Ramos M, Peerani E, Hirani P, Gauthier V, Liu Y, Maniscalco G, Rajeeve V, Cutillas P, Trevisan C, Pozzobon M, Lockley M, Rastrick J, Läubli H, White A and Pearce OMT
Nature Communications, Springer Nature vol. 14 (1) 
15-05-2023

Abstract 5841: Exploring the role of versican in immune exclusion within triple negative breast cancer
Hirani P, Alonge KM, Pennington DJ, Cutillas PR, Wight TN and Pearce OM
Cancer Research, American Association For Cancer Research (Aacr) vol. 83 (7_Supplement), 5841-5841.  
04-04-2023

Abstract 1339: Targeting specific extracellular matrix proteins to reactivate T cell trafficking in triple-negative breast cancer
Gauthier V, Tyler E, Liu Y, Sharp TV and Pearce OM
Cancer Research, American Association For Cancer Research (Aacr) vol. 83 (7_Supplement), 1339-1339.  
04-04-2023

YAP activation inhibits inflammatory signalling and cartilage breakdown associated with reduced primary cilia expression
Meng H, Fu S, Ferreira MB, Hou Y, Pearce OM, Gavara N and Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 31 (5), 600-612.  
08-11-2022

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade
Stanczak MA, Rodrigues Mantuano N, Kirchhammer N, Sanin DE, Jacob F, Coelho R, Everest-Dass AV, Wang J, Trefny MP, Monaco G, Bärenwaldt A, Gray MA, Petrone A, Kashyap AS, Glatz K, Kasenda B, Normington K, Broderick J, Peng L, Pearce OMT, Pearce EL, Bertozzi CR, Zippelius A and Läubli H
Science Translational Medicine, American Association For The Advancement of Science (Aaas) vol. 14 (669), eabj1270-eabj1270.  
02-11-2022

Editorial: Glycans: Masters of immunity, from cancers to inflammatory disease
Beatson R, Läubli H, Pearce OMT and Reis CA
Frontiers in Immunology, Frontiers vol. 13 
17-08-2022

TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian CancerTGFBI and Ovarian Cancer
Lecker LSM, Berlato C, Maniati E, Delaine-Smith R, Pearce OMT, Heath O, Nichols SJ, Trevisan C, Novak M, McDermott J, Brenton JD, Cutillas PR, Rajeeve V, Hennino A, Drapkin R, Loessner D and Balkwill FR
Cancer Research, American Association For Cancer Research (Aacr) vol. 81 (22), 5706-5719.  
24-09-2021

Targeting Versican as a Potential Immunotherapeutic Strategy in the Treatment of Cancer
Hirani P, Gauthier V, Allen CE, Wight TN and Pearce OMT
Frontiers in Oncology, Frontiers vol. 11 
30-08-2021

Basement membrane stiffness determines metastases formation
Reuten R, Zendehroud S, Nicolau M, Fleischhauer L, Laitala A, Kiderlen S, Nikodemus D, Wullkopf L, Nielsen SR, McNeilly S, Prein C, Rafaeva M, Schoof EM, Furtwängler B, Porse BT, Kim H, Won KJ, Sudhop S, Zornhagen KW, Suhr F, Maniati E, Pearce OMT, Koch M, Oddershede LB, Van Agtmael T, Madsen CD, Mayorca-Guiliani AE, Bloch W, Netz RR and Clausen-Schaumann H
Nature Materials, Springer Nature vol. 20 (6), 892-903.  
25-01-2021

A Sweet Approach to Heat Up Cancer Response to Immunotherapy
Pearce OMT and Läubli H
Cancer Discovery, American Association For Cancer Research (Aacr) vol. 10 (12), 1789-1790.  
01-12-2020

FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer
Zaghdoudi S, Decaup E, Belhabib I, Samain R, Cassant-Sourdy S, Rochotte J, Brunel A, Schlaepfer D, Cros J, Neuzillet C, Strehaiano M, Alard A, Tomasini R, Rajeeve V, Perraud A, Mathonnet M, Pearce OMT, Martineau Y, Pyronnet S, Bousquet C and Jean C
Embo Molecular Medicine vol. 12 (11) 
06-11-2020

FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer
Zaghdoudi S, Decaup E, Belhabib I, Samain R, Cassant‐Sourdy S, Rochotte J, Brunel A, Schlaepfer D, Cros J, Neuzillet C, Strehaiano M, Alard A, Tomasini R, Rajeeve V, Perraud A, Mathonnet M, Pearce OM, Martineau Y, Pyronnet S, Bousquet C and Jean C
Embo Molecular Medicine, Springer Nature vol. 12 (11) 
07-10-2020

Versican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation
Wight TN, Kang I, Evanko SP, Harten IA, Chang MY, Pearce OMT, Allen CE and Frevert CW
Frontiers in Immunology, Frontiers Media vol. 11 
24-03-2020

Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment
Maniati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C, Delaine-Smith RM, Pearce OMT, Hirani P, Joyce JD, Szabova L, Perets R, Sansom OJ, Drapkin R, Bailey P and Balkwill F
Ssrn Electronic Journal, Elsevier Bv 
14-01-2020

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics
Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR and Hynes RO
Journal of Proteome Research vol. 16 (8), 3083-3091.  
01-12-2018

Cancer Immunotherapy
Pearce OMT and Läubli H
Glycobiology, Oxford University Press (Oup) vol. 28 (9), 638-639.  
10-07-2018

Cancer glycan epitopes: biosynthesis, structure, and function.
Pearce OM
Glycobiology 
13-03-2018

N-glycolyl groups of nonhuman chondroitin sulfates survive in ancient fossils.
Bergfeld AK, Lawrence R, Diaz SL, Pearce OMT, Ghaderi D, Gagneux P, Leakey MG and Varki A
Proc Natl Acad Sci U S A vol. 114 (39), E8155-E8164.  
26-09-2017

A strong B cell response is part of the immune landscape in human high-grade serous ovarian metastases.
Montfort A, Pearce OMT, Maniati E, Vincent B, Bixby LM, Bo hm S, Dowe T, Wilkes EH, Chakravarty P, Thompson R, Topping J, Cutillas PR, Lockley M, Serody JS, Capasso M and Balkwill FR
Clinical Cancer Research, American Association For Cancer Research 
27-06-2016

Neoadjuvant chemotherapy modulates the immune microenvironment in metastases of tubo-ovarian high-grade serous carcinoma
BALKWILL F, Anne Montfort and Oliver Pearce
Clinical Cancer Research, American Association For Cancer Research 
01-04-2016

Sialic acids in cancer biology and immunity
Pearce OMT and Läubli H
Glycobiology, Oxford University Press (Oup) vol. 26 (2), 111-128.  
30-10-2015

Interleukin-6 Stimulates Defective Angiogenesis
Gopinathan G, Milagre C, Pearce OMT, Reynolds LE, Hodivala-Dilke K, Leinster DA, Zhong H, Hollingsworth RE, Thompson R, Whiteford JR and Balkwill F
Cancer Research, American Association For Cancer Research (Aacr) vol. 75 (15), 3098-3107.  
01-08-2015

Abstract 4162: Interleukin–6 stimulates defective angiogenesis
Gopinathan G, Milagre C, Pearce OMT, Reynolds L, Hodivala-Dilke K, Leinster A, Zhong H, Hollingsworth RE, Thompson R, Whiteford JR and Balkwill F
Cancer Research, American Association For Cancer Research (Aacr) vol. 75 (15_Supplement), 4162-4162.  
01-08-2015

Rapid Trimming of Cell Surface Polysialic Acid (PolySia) by Exovesicular Sialidase Triggers Release of Preexisting Surface Neurotrophin*
Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OMT, Kiso M, Miyagi T, Sawada M, Varki A, Kitajima K and Sato C
Journal of Biological Chemistry, Elsevier vol. 290 (21), 13202-13214.  
06-03-2015

Reply to Mackenzie: A comparison of Neu5Gc and α-gal xenoantigens
Pearce OMT, Samraj AN, Läubli H, Varki NM and Varki A
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 112 (12), e1405-e1405.  
20-02-2015

Siglec receptors impact mammalian lifespan by modulating oxidative stress
Schwarz F, Pearce OM, Wang X, Samraj AN, Läubli H, Garcia JO, Lin H, Fu X, Garcia-Bingman A, Secrest P, Romanoski CE, Heyser C, Glass CK, Hazen SL, Varki N, Varki A and Gagneux P
Elife, Elife vol. 4 
01-01-2015

A red meat-derived glycan promotes inflammation and cancer progression
Samraj AN, Pearce OMT, Läubli H, Crittenden AN, Bergfeld AK, Banda K, Gregg CJ, Bingman AE, Secrest P, Diaz SL, Varki NM and Varki A
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 112 (2), 542-547.  
29-12-2014

Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer
Läubli H, Pearce OMT, Schwarz F, Siddiqui SS, Deng L, Stanczak MA, Verhagen A, Secrest P, Lusk C, Schwartz AG, Varki NM, Bui JD and Varki A
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 111 (39), 14211-14216.  
15-09-2014

Hormesis in cancer immunology
Pearce OM, Läubli H, Bui J and Varki A
Oncoimmunology, Taylor & Francis vol. 3 (6) 
01-06-2014

Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies
Pearce OMT, Läubli H, Verhagen A, Secrest P, Zhang J, Varki NM, Crocker PR, Bui JD and Varki A
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 111 (16), 5998-6003.  
07-04-2014

Discovery of novel monosaccharides in animal glycans: natural occurrence of N‐glycolylhexosamines (607.6)
Bergfeld A, Lawrence R, Diaz S, Pearce O, van Vleet J, Esko J, Choudhury B and Varki A
The Faseb Journal, Wiley vol. 28 (S1) 
01-04-2014

Enhanced T Cell Function in a Mouse Model of Human Glycosylation
Buchlis G, Odorizzi P, Soto PC, Pearce OMT, Hui DJ, Jordan MS, Varki A, Wherry EJ and High KA
The Journal of Immunology, The American Association of Immunologists vol. 191 (1), 228-237.  
01-07-2013

Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups ELUCIDATING THE INTRACELLULAR FATE OF THE NON-HUMAN SIALIC ACID N-GLYCOLYLNEURAMINIC ACID*
Bergfeld AK, Pearce OMT, Diaz SL, Pham T and Varki A
Journal of Biological Chemistry, Elsevier vol. 287 (34), 28865-28881.  
12-06-2012

Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups RESISTANCE OF α2–8-LINKED N-GLYCOLYLNEURAMINIC ACID TO ENZYMATIC CLEAVAGE*
Davies LRL, Pearce OMT, Tessier MB, Assar S, Smutova V, Pajunen M, Sumida M, Sato C, Kitajima K, Finne J, Gagneux P, Pshezhetsky A, Woods R and Varki A
Journal of Biological Chemistry, Elsevier vol. 287 (34), 28917-28931.  
12-06-2012

Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups INCORPORATION OF N-GLYCOLYLHEXOSAMINES INTO MAMMALIAN GLYCANS BY FEEDING N-GLYCOLYLGALACTOSAMINE*
Bergfeld AK, Pearce OMT, Diaz SL, Lawrence R, Vocadlo DJ, Choudhury B, Esko JD and Varki A
Journal of Biological Chemistry, Elsevier vol. 287 (34), 28898-28916.  
12-06-2012

Unusual chemical and enzymatic stability of polysialic acid containing N‐glycolylneuraminic acid
Davies L, Pearce O, Tessier M, Assar S, Smutova V, Pshezhetsky A, Woods R and Varki A
The Faseb Journal, Wiley vol. 26 (S1), 610.1-610.1.  
01-04-2012

Intrinsically Hyperactive and Hyperproliferative CD8+ T Cells In Cmah-/- Mice as a Model of Human Gene Transfer Responses.
Buchlis G, Mingozzi F, Soto PC, Pearce O, Hui DJ, Varki AP and High KA
Blood, American Society of Hematology vol. 116 (21) 
19-11-2010

Chemo-enzymatic synthesis of the carbohydrate antigen N-glycolylneuraminic acid from glucose
Pearce OMT and Varki A
Carbohydrate Research, Elsevier vol. 345 (9), 1225-1229.  
09-04-2010

Glycoviruses: Chemical Glycosylation Retargets Adenoviral Gene Transfer
Pearce OMT, Fisher KD, Humphries J, Seymour LW, Smith A and Davis BG
Angewandte Chemie International Edition, Wiley vol. 44 (7), 1057-1061.  
01-02-2005

Titelbild: Glycoviruses: Chemical Glycosylation Retargets Adenoviral Gene Transfer (Angew. Chem. 7/2005)
Pearce OMT, Fisher KD, Humphries J, Seymour LW, Smith A and Davis BG
Angewandte Chemie, Wiley vol. 117 (7), 1005-1005.  
01-02-2005

Cover Picture: Glycoviruses: Chemical Glycosylation Retargets Adenoviral Gene Transfer (Angew. Chem. Int. Ed. 7/2005)
Pearce OMT, Fisher KD, Humphries J, Seymour LW, Smith A and Davis BG
Angewandte Chemie International Edition, Wiley vol. 44 (7), 983-983.  
01-02-2005