Altered Cellular Metabolism Is a Consequence of Loss of the Ataxia-Linked Protein Sacsin
Perna L, Salsbury G, Dushti M, Smith CJ, Morales V, Bianchi K, Czibik G and Chapple JP
International Journal of Molecular Sciences, Mdpi vol. 25 (24) 
10-12-2024

Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling
Mcleod JC, Lim C, Stokes T, Sharif J-A, Zeynalli V, Wiens L, D’Souza AC, Colenso-Semple L, McKendry J, Morton RW, Mitchell CJ, Oikawa SY, Wahlestedt C, Chapple JP, McGlory C, Timmons JA and Phillips SM
Nar Molecular Medicine, Oxford University Press (Oup) vol. 1 (4) 
01-10-2024

N-SREBP2 Provides a Mechanism for Dynamic Control of Cellular Cholesterol Homeostasis
Ozkan-Nikitaras T, Grzesik DJ, Romano LEL, Chapple JP, King PJ and Shoulders CC
Cells, Mdpi vol. 13 (15) 
25-07-2024

J-domain proteins: From molecular mechanisms to diseases
Marszalek J, De Los Rios P, Cyr D, Mayer MP, Adupa V, Andréasson C, Blatch GL, Braun JEA, Brodsky JL, Bukau B, Chapple JP, Conz C, Dementin S, Genevaux P, Genest O, Goloubinoff P, Gestwicki J, Hammond CM, Hines JK, Ishikawa K, Joachimiak LA, Kirstein J, Liberek K, Mokranjac D, Nillegoda N, Ramos CHI, Rebeaud M, Ron D, Rospert S and Sahi C
Cell Stress and Chaperones, Elsevier vol. 29 (1), 21-33.  
23-12-2023

AlphaFold predicted structure of the Hsp90-like domains of the neurodegeneration linked protein sacsin reveals key residues for ATPase activity
Perna L, Castelli M, Frasnetti E, Romano LEL, Colombo G, Prodromou C and Chapple JP
Frontiers in Molecular Biosciences, Frontiers vol. 9 
13-01-2023

HSP70-HSP90 Chaperone Networking in Protein-Misfolding Disease
Prodromou C, Aran-Guiu X, Oberoi J, Perna L, Chapple JP and van der Spuy J
Subcellular Biochemistry, Springer Nature vol. 101, 389-425.  
16-12-2022

Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization
Romano LEL, Aw WY, Hixson KM, Novoselova TV, Havener TM, Howell S, Taylor-Blake B, Hall CL, Xing L, Beri J, Nethisinghe S, Perna L, Hatimy A, Altadonna GC, Graves LM, Herring LE, Hickey AJ, Thalassinos K, Chapple JP and Wolter JM
Cell Reports, Elsevier vol. 41 (5) 
01-11-2022

The immune cell infiltrate in the tumour microenvironment of phaeochromocytomas and paragangliomas
Tufton N, Hearnden RJ, Berney DM, Drake WM, Parvanta L, Chapple JP and Akker SA
Endocrine Related Cancer, Bioscientifica vol. 29 (11), 589-598.  
19-09-2022

Modelling autosomal dominant optic atrophy associated with OPA1 variants in iPSC-derived retinal ganglion cells
Sladen PE, Jovanovic K, Guarascio R, Ottaviani D, Salsbury G, Novoselova T, Chapple JP, Yu-Wai-Man P and Cheetham ME
Human Molecular Genetics, Oxford University Press (Oup) vol. 31 (20), 3478-3493.  
02-06-2022

Antiproliferative effects of metformin in cellular models of pheochromocytoma
Meireles CG, Lourenço de Lima C, Martins de Paula Oliveira M, Abe da Rocha Miranda R, Romano L, Yo-Stella Brashaw T, Neves da Silva Guerra E, de Assis Rocha Neves F, Chapple JP, Simeoni LA and Lofrano-Porto A
Molecular and Cellular Endocrinology, Elsevier vol. 539 
09-10-2021

CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs
Sladen PE, Perdigão PRL, Salsbury G, Novoselova T, van der Spuy J, Chapple JP, Yu-Wai-Man P and Cheetham ME
Molecular Therapy - Nucleic Acids, Elsevier vol. 26, 432-443.  
19-08-2021

GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage
Callender LA, Schroth J, Carroll EC, Garrod-Ketchley C, Romano LEL, Hendy E, Kelly A, Lavender P, Akbar AN, Chapple JP and Henson S
Nature Communications, Nature Research (Part of Springer Nature) 
07-06-2021

Polycystin-2 is required for chondrocyte mechanotransduction and traffics to the primary cilium in response to mechanical stimulation
Thompson C, Mcfie M, Chapple J, BEALES P and Knight M
International Journal of Molecular Sciences, Mdpi Ag 
21-04-2021

Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response
Desai R, East DA, Hardy L, Faccenda D, Rigon M, Crosby J, Alvarez MS, Singh A, Mainenti M, Hussey LK, Bentham R, Szabadkai G, Zappulli V, Dhoot GK, Romano LE, Xia D, Coppens I, Hamacher-Brady A, Chapple JP, Abeti R, Fleck RA, Vizcay-Barrena G, Smith K and Campanella M
Science Advances, American Association For The Advancement of Science (Aaas) vol. 6 (51) 
18-12-2020

Corrigendum to: The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control
Athanasiou D, Bevilacqua D, Aguila M, McCulley C, Kanuga N, Iwawaki T, Chapple JP and Cheetham ME
Human Molecular Genetics, Oxford University Press (Oup) vol. 29 (19), 3338-3339.  
28-09-2020

Oncometabolite induced primary cilia loss in pheochromocytoma
O’Toole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM, Sharp TV, Barnes MR, Srirangalingam U, Drake WM and Chapple JP
Endocrine-Related Cancer vol. 26 (1), 165-180.  
01-01-2019

Can novel stem cell models help unpick the pathogenesis of the Triple A syndrome?
Costa ARD, Qarin S, Bradshaw T, Watson D, Prasad R, Metherell LA, Barnes MR, Skarnes W, Chapple JP and Storr HL
Endocrine Abstracts, Bioscientifica 
18-10-2018

Sacsin, mutated in the ataxia ARSACS, regulates intermediate filament assembly and dynamics
Gentil BJ, Lai G-T, Menade M, Larivière R, Minotti S, Gehring K, Chapple J-P, Brais B and Durham HD
The Faseb Journal, Wiley vol. 33 (2), 2982-2994.  
17-10-2018

Optical coherence tomography in autosomal recessive spastic ataxia of Charlevoix-Saguenay
Parkinson MH, Bartmann AP, Clayton LMS, Nethisinghe S, Pfundt R, Chapple JP, Reilly MM, Manji H, Wood NJ, Bremner F and Giunti P
Brain, Oxford University Press (Oup) vol. 141 (4), 989-999.  
12-03-2018

Novel evidence implies that ALADIN, the triple A syndrome gene product is involved in mitochondrial physiology
Da CAR, Meimaridou E, Prasad R, Metherell LA, Chapple JP and Storr HL
Endocrine Abstracts, Bioscientifica 
30-10-2017

Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling.
Thompson CL, Plant JC, Wann AK, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP and Knight MM
Eur Cell Mater vol. 34, 128-141.  
20-09-2017

Topography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis.
Zhang J, Dalbay MT, Luo X, Vrij E, Barbieri D, Moroni L, de Bruijn JD, van Blitterswijk CA, Chapple JP, Knight MM and Yuan H
Acta Biomater vol. 57, 487-497.  
15-07-2017

Altered organisation of the intermediate filament cytoskeleton and relocalisation of proteostasis modulators in cells lacking the ataxia protein sacsin
CHAPPLE JP
Human Molecular Genetics, Oxford University Press 
23-05-2017

Arl3 and RP2 regulate the trafficking of ciliary tip kinesins.
Schwarz N, Lane A, Jovanovic K, Parfitt DA, Aguila M, Thompson CL, da Cruz L, Coffey PJ, Chapple JP, Hardcastle AJ and Cheetham ME
Hum Mol Genet, Oxford University Press vol. 26 (13), 2480-2492.  
21-04-2017

Arl3 and RP2 regulate the trafficking of ciliary tip kinesins. (CORRIGENDUM)
Schwarz N, Lane A, Jovanovic K, Parfitt DA, Aguila M, Thompson CL, da Cruz L, Coffey PJ, Chapple JP, Hardcastle AJ and Cheetham ME
Hum Mol Genet, Oxford University Press vol. 26 (17), 3451-3451.  
21-04-2017

Primary cilia: a link between hormone signalling and endocrine-related cancers?
O'Toole SM and Chapple JP
Biochemical Society Transactions, Portland Press vol. 44 (5), 1227-1234.  
15-10-2016

A reduction in Drp1 mediated fission compromises mitochondrial health in autosomal recessive spastic ataxia of Charlevoix Saguenay
CHAPPLE JP, Bradshaw TY, Romano LEL, Duncan EJ, Nethisinghe S, Abeti R, Michael GJ, Giunti P and Vermeer S
Human Molecular Genetics, Oxford University Press (Oup): Policy B - Oxford Open Option B vol. 25 (15), 3232-3244.  
10-06-2016

The role of primary cilia in the molecular pathogenesis of phaeochromocytoma
O'Toole S, Srirangalingam U, Drake W and Chapple JP
Endocrine Abstracts, Bioscientifica 
13-05-2016

Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β
Thompson CL, Patel R, Kelly T-AN, Wann AKT, Hung CT, Chapple JP and Knight MM
Arthritis Research & Therapy vol. 17 (1) 
24-12-2015

Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF‐1r Onto the Primary Cilium Associated With Cilia Elongation
Dalbay MT, Thorpe SD, Connelly JT, Chapple JP and Knight MM
Stem Cells, Oxford University Press (Oup) vol. 33 (6), 1952-1961.  
21-05-2015

Molecular and functional studies of retinal degeneration as a clinical presentation of SACS-related disorder
Blumkin L, Bradshaw T, Michelson M, Kopler T, Dahari D, Lerman-Sagie T, Lev D, Chapple JP and Leshinsky-Silver E
European Journal of Paediatric Neurology, Elsevier vol. 19 (4), 472-476.  
03-03-2015

Competitive interactions between hedgehog and cytokine signalling: crosstalk at the chondrocyte primary cilium?
Thompson CL, Wann AKT, Chapple JP, Poole CA and Knight MM
International Journal of Experimental Pathology vol. 96 (2), A8-A8.  
01-01-2015

The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control.
Athanasiou D, Bevilacqua D, Aguila M, McCulley C, Kanuga N, Iwawaki T, Chapple JP and Cheetham ME
Hum Mol Genet vol. 23 (24), 6594-6606.  
15-12-2014

The Role of HSP70 and Its Co-chaperones in Protein Misfolding, Aggregation and Disease
Duncan EJ, Cheetham ME, Chapple JP and van der Spuy J
Subcellular Biochemistry, Springer Nature vol. 78, 243-273.  
09-12-2014

The primary cilium influences interleukin-1β-induced NFκB signalling by regulating IKK activity.
Wann AKT, Chapple JP and Knight MM
Cell Signal vol. 26 (8), 1735-1742.  
01-08-2014

Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes.
Thompson CL, Chapple JP and Knight MM
Osteoarthritis Cartilage vol. 22 (3), 490-498.  
01-03-2014

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium.
Wann AK, Thompson CL, Chapple JP and Knight MM
Cilia vol. 2 (1) 
13-12-2013

Familial glucocorticoid deficiency: New genes and mechanisms.
Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL and Metherell LA
Mol Cell Endocrinol vol. 371 (1-2), 195-200.  
22-05-2013

Familial glucocorticoid deficiency: New genes and mechanisms
Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL and Metherell LA
Molecular and Cellular Endocrinology vol. 371 (1-2), 195-200.  
22-05-2013

Heat shock induces rapid resorption of primary cilia
Prodromou NV, Thompson CL, Osborn DPS, Cogger KF, Ashworth R, Knight MM, Beales PL and Chapple JP
Development, The Company of Biologists vol. 139 (24), e2408-e2408.  
15-12-2012

Heat shock induces rapid resorption of primary cilia
Prodromou NV, Thompson CL, Osborn DPS, Cogger KF, Ashworth R, Knight MM, Beales PL and Chapple JP
Journal of Cell Science vol. 125 (18), 4297-4305.  
01-12-2012

Heat-shock induces rapid resorption of primary cilia
Thompson C, Prodromou N, Osborn D, Ashworth R, Knight M, Beales P and Chapple J
Cilia, Springer Nature vol. 1 (Suppl 1) 
01-11-2012

Mechanical strain disrupts primary cilia structure and modulates hedgehog signalling in adult chondrocytes
Thompson C, Chapple J and Knight M
Cilia, Springer Nature vol. 1 (Suppl 1) 
01-11-2012

BiP prevents rod opsin aggregation.
Athanasiou D, Kosmaoglou M, Kanuga N, Novoselov SS, Paton AW, Paton JC, Chapple JP and Cheetham ME
Mol Biol Cell vol. 23 (18), 3522-3531.  
01-09-2012

Somatostatin analogs modulate AIP in somatotroph adenomas: the role of the ZAC1 pathway.
Chahal HS, Trivellin G, Leontiou CA, Alband N, Fowkes RC, Tahir A, Igreja SC, Chapple JP, Jordan S, Lupp A, Schulz S, Ansorge O, Karavitaki N, Carlsen E, Wass JAH, Grossman AB and Korbonits M
J Clin Endocrinol Metab vol. 97 (8), E1411-E1420.  
01-08-2012

Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency.
Meimaridou E, Kowalczyk J, Guasti L, Hughes CR, Wagner F, Frommolt P, Nürnberg P, Mann NP, Banerjee R, Saka HN, Chapple JP, King PJ, Clark AJL and Metherell LA
Nat Genet vol. 44 (7), 740-742.  
27-05-2012

Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)
Girard M, Lariviere R, Parfitt DA, Deane EC, Gaudet R, Nossova N, Blondeau F, Prenosil G, Vermeulen EGM, Duchen MR, Richter A, Shoubridge EA, Gehring K, McKinney RA, Brais B, Chapple JP and McPherson PS
Proceedings of The National Academy of Sciences of The United States of America vol. 109 (5), 1661-1666.  
01-01-2012

Hsp70 Chaperone Systems in Vesicular Trafficking
Chapple JP, Parfitt DA and Campbell DC
In Cellular Trafficking of Cell Stress Proteins in Health and Disease, Springer Nature 87-101.  
01-01-2012

Heat-shock induces rapid resorption of primary cilia
Thompson CL, Prodromou NV, Osborn DP, Ashworth R, Knight MM, Beales PL and Chapple JP
Cilia vol. 1 (Suppl 1), P52-P52.  
01-01-2012

The cytosolic chaperone Hsc70 promotes traffic to the cell surface of intracellular retained melanocortin-4 receptor mutants.
Meimaridou E, Gooljar SB, Ramnarace N, Anthonypillai L, Clark AJL and Chapple JP
Mol Endocrinol vol. 25 (9), 1650-1660.  
01-09-2011

Retinal Imaging in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay
Nethisinghe S, Clayton L, Vermeer S, Chapple JP, Reilly M, Bremner F and Giunti P
Neuro-Ophthalmology vol. 35 (4), 197-201.  
01-08-2011

Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families.
Igreja S, Chahal HS, King P, Bolger GB, Srirangalingam U, Guasti L, Chapple JP, Trivellin G, Gueorguiev M, Guegan K, Stals K, Khoo B, Kumar AV, Ellard S, Grossman AB, Korbonits M and International FIPA Consortium
Hum Mutat vol. 31 (8), 950-960.  
01-08-2010

Clinical, genetic and molecular characterization of patients with familial isolated pituitary adenomas (FIPA).
Chahal HS, Chapple JP, Frohman LA, Grossman AB and Korbonits M
Trends Endocrinol Metab vol. 21 (7), 419-427.  
01-07-2010

The binding of the molecular chaperone Hsc70 to the prion protein PrP is modulated by pH and copper
Wilkins S, Choglay AA, Chapple JP, van der Spuy J, Rhie A, Birkett CR and Cheetham ME
The International Journal of Biochemistry & Cell Biology, Elsevier vol. 42 (7), 1226-1232.  
29-04-2010

Deficiency of ferritin heavy-chain nuclear import in triple a syndrome implies nuclear oxidative damage as the primary disease mechanism.
Storr HL, Kind B, Parfitt DA, Chapple JP, Lorenz M, Koehler K, Huebner A and Clark AJL
Mol Endocrinol vol. 23 (12), 2086-2094.  
01-12-2009

Can faulty antennae increase adiposity? The link between cilia proteins and obesity.
Sen Gupta P, Prodromou NV and Chapple JP
J Endocrinol vol. 203 (3), 327-336.  
01-12-2009

Deficiency of Ferritin Heavy-Chain Nuclear Import in Triple A Syndrome Implies Nuclear Oxidative Damage as the Primary Disease Mechanism
Storr HL, Kind B, Parfitt DA, Chapple JP, Lorenz M, Koehler K, Huebner A and Clark AJL
The Journal of Clinical Endocrinology & Metabolism, The Endocrine Society vol. 94 (11), 4626-4626.  
01-11-2009

The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1.
Parfitt DA, Michael GJ, Vermeulen EGM, Prodromou NV, Webb TR, Gallo J-M, Cheetham ME, Nicoll WS, Blatch GL and Chapple JP
Hum Mol Genet vol. 18 (9), 1556-1565.  
01-05-2009

MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family.
Chan LF, Webb TR, Chung T-T, Meimaridou E, Cooray SN, Guasti L, Chapple JP, Egertová M, Elphick MR, Cheetham ME, Metherell LA and Clark AJL
Proc Natl Acad Sci U S A vol. 106 (15), 6146-6151.  
14-04-2009

Distinct melanocortin 2 receptor accessory protein domains are required for melanocortin 2 receptor interaction and promotion of receptor trafficking.
Webb TR, Chan L, Cooray SN, Cheetham ME, Chapple JP and Clark AJL
Endocrinology vol. 150 (2), 720-726.  
01-02-2009

From hatching to dispatching: the multiple cellular roles of the Hsp70 molecular chaperone machinery.
Meimaridou E, Gooljar SB and Chapple JP
J Mol Endocrinol vol. 42 (1), 1-9.  
01-01-2009

Focal distortion of the nuclear envelope by huntingtin aggregates revealed by lamin immunostaining
Chapple JP, Bros-Facer V, Butler R and Gallo JM
Neurosci Lett vol. 447 (2-3), 172-174.  
12-12-2008

The majority of adrenocorticotropin receptor (melanocortin 2 receptor) mutations found in familial glucocorticoid deficiency type 1 lead to defective trafficking of the receptor to the cell surface.
Chung TT, Webb TR, Chan LF, Cooray SN, Metherell LA, King PJ, Chapple JP and Clark AJL
J Clin Endocrinol Metab vol. 93 (12), 4948-4954.  
01-12-2008

The role of the aryl hydrocarbon receptor-interacting protein gene in familial and sporadic pituitary adenomas.
Leontiou CA, Gueorguiev M, van der Spuy J, Quinton R, Lolli F, Hassan S, Chahal HS, Igreja SC, Jordan S, Rowe J, Stolbrink M, Christian HC, Wray J, Bishop-Bailey D, Berney DM, Wass JAH, Popovic V, Ribeiro-Oliveira A, Gadelha MR, Monson JP, Akker SA, Davis JRE, Clayton RN, Yoshimoto K, Iwata T, Matsuno A, Eguchi K, Musat M, Flanagan D and Peters G
J Clin Endocrinol Metab vol. 93 (6), 2390-2401.  
01-06-2008

The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line.
Cooray SN, Almiro Do Vale I, Leung K-Y, Webb TR, Chapple JP, Egertová M, Cheetham ME, Elphick MR and Clark AJL
Endocrinology vol. 149 (4), 1935-1941.  
01-04-2008

Expression, localization and Tau Exon 10 splicing activity of the brain RNA-binding protein TNRC4
CHAPPLE JP, Gallo JM, Cooper TA, Dev A, Martin TR and Anthony K
Human Molecular Genetics vol. 16 (22), 2760-2769.  
01-11-2007

Expression, localization and tau exon 10 splicing activity of the brain RNA-binding protein TNRC4
CHAPPLE JP, Dev A, Anthony K, Cooper TA, Rodriguez-Martin T and Gallo J-M
Human Molecular Genetics vol. 16 (22), 2760-2769.  
01-11-2007

Hsp40 molecules that target to the ubiquitin-proteasome system decrease inclusion formation in models of polyglutamine disease
Howarth JL, Kelly S, Keasey MP, Glover CPJ, Lee YB, Mitrophanous K, Chapple JP, Gallo JM, Cheetham ME and Uney JB
Mol Ther vol. 15 (6), 1100-1105.  
01-06-2007

Hsp40 Molecules That Target to the Ubiquitin-proteasome System Decrease Inclusion Formation in Models of Polyglutamine Disease.
Howarth JL, Kelly S, Keasey MP, Glover C, Lee Y-B, Mitrophanous K, Chapple JP, Gallo JM, Cheetham ME and Uney JB
Mol Ther vol. 15 (6), 1100-1105.  
01-06-2007

The Notch-1 intracellular domain is found in sub-nuclear bodies in SH-SY5Y neuroblastomas and in primary cortical neurons
Hooper C, Chapple JP, Lovestone S and Killick R
Neurosci Lett vol. 415 (2), 135-139.  
26-03-2007

Cytosolic and ER J-domains of mammalian and parasitic origin can functionally interact with DnaK
Nicoll WS, Botha M, McNamara C, Schlange M, Pesce ER, Boshoff A, Ludewig MH, Zimmermann R, Cheetham ME, Chapple JP and Blatch GL
Int J Biochem Cell B vol. 39 (4), 736-751.  
01-01-2007

TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones
Hooper C, Tavassoli M, Chapple JP, Uwanogho D, Goodyear R, Melino G, Lovestone S and Killick R
J Neurochem vol. 99 (3), 989-999.  
01-11-2006

A candidate interacting protein for the nuclear pore protein ALADIN: a potential pathogenic mechanism for the triple A syndrome
Storr H, Koehler K, Huebner A, Chapple JP and Clark AJL
Horm Res vol. 65, 16-16.  
01-01-2006

Organization on the plasma membrane of the retinitis pigmentosa protein RP2: investigation of association with detergent-resistant membranes and polarized sorting
CHAPPLE JP, Adamson P, Matter K, Bailey TA, Hardcastle AJ and Grayson C
Biochem J vol. 372 (pt 2), 427-433.  
01-01-2006

Erratum: Corrigendum: Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates
Ross AJ, May-Simera H, Eichers ER, Kai M, Hill J, Jagger DJ, Leitch CC, Chapple JP, Munro PM, Fisher S, Tan PL, Phillips HM, Leroux MR, Henderson DJ, Murdoch JN, Copp AJ, Eliot M-M, Lupski JR, Kemp DT, Dollfus H, Tada M, Katsanis N, Forge A and Beales PL
Nature Genetics, Springer Nature vol. 37 (12), 1381-1381.  
01-12-2005

Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates
CHAPPLE JP, Fisher S, Tan PL, Phillips HM, Leitch CC, Eliot MM, Copp AJ, Katsanis N, Dollfus H, Kemp DT, Tada M, Ross AJ, May-Simera H, Eichers ER, Kai M, Forge A, Beales PL, Leroux MR, Murdoch JN, Henderson DJ, Munro PM, Jagger DJ, Hill J and Lupski JR
Nature Genetics vol. 37 (10), 1135-1140.  
01-10-2005

HSJ1 Is a Neuronal Shuttling Factor for the Sorting of Chaperone Clients to the Proteasome
CHAPPLE JP, Cheetham ME, Westhoff B, Van Der Spuy SJ and Hohfeld J
Current Biology vol. 15 (11), 1058-1064.  
01-06-2005

Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2
David A, CHAPPLE JP, Cooray S, Metherell LA, Ruschendorf F and Becker C
Nature Genetics vol. 37 (2), 166-170.  
01-02-2005

Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy
CHAPPLE JP, Cheetham ME, Van Der SJ and Mendes HF
Trends Mol Med vol. 11 (4), 177-185.  
01-01-2005

Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2
CHAPPLE JP, Banerjee R, Gaasenbeek M, Cheetham ME, Ocaka L and Inglis-Broadgate SL
Gene vol. 356, 19-31.  
01-01-2005

Assay and functional analysis of the ARL3 effector RP2 involved in X-linked retinitis pigmentosa.
Evans RJ, Chapple JP, Grayson C, Hardcastle AJ and Cheetham ME
Methods Enzymol vol. 404, 468-480.  
01-01-2005

Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases
Longshaw VM, Chapple JP, Balda MS, Cheetham ME and Blatch GL
Journal of Cell Science, The Company of Biologists vol. 117 (5), 701-710.  
15-02-2004

An atypical phenotype of macular and peripapillary retinal atrophy caused by a mutation in the RP2 gene
CHAPPLE JP, Holder GE, Egan CA, Grayson C, Dandekar SS and Ebenezer ND
Br. J Opthalmol vol. 88 (4), 528-532.  
01-01-2004

Neuronal DnaJ proteins HSJ1a and HSJ1b: a role in linking the Hsp70 chaperone machine to the ubiquitin-proteasome system?
CHAPPLE JP, Cheetham ME, Poopalasundaram S and Van Der SJ
Biochem Soc Trans vol. 32 (pt4), 640-642.  
01-01-2004

Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases
CHAPPLE JP, Cheetham ME, Blatch GL, Longshaw VM and Balda MS
J Cell Sci vol. 117 (pt 5), 701-710.  
01-01-2004

The chaperone environment at the cytoplasmic face of the endoplasmic reticulum can modulate rhodopsin processing and inclusion formation.
Chapple JP and Cheetham ME
J Biol Chem vol. 278 (21), 19087-19094.  
23-05-2003

The Chaperone Environment at the Cytoplasmic Face of the Endoplasmic Reticulum Can Modulate Rhodopsin Processing and Inclusion Formation
CHAPPLE JP and Cheetham ME
Journal of Biological Chemistry vol. 278 (21), 19087-19094.  
01-05-2003

Delineation of the plasma membrane targeting domain of the X-linked retinitis pigmentosa protein RP2.
Chapple JP, Hardcastle AJ, Grayson C, Willison KR and Cheetham ME
Invest Ophthalmol Vis Sci vol. 43 (6), 2015-2020.  
01-06-2002

The Leber congenital amaurosis gene product AIPL1 is localized exclusively in rod photoreceptors of the adult human retina.
van der Spuy J, Chapple JP, Clark BJ, Luthert PJ, Sethi CS and Cheetham ME
Hum Mol Genet vol. 11 (7), 823-831.  
01-04-2002

In vitro analysis of aminoglycoside therapy for the Arg120stop nonsense mutation in RP2 patients
CHAPPLE JP, Willison KR, Grayson C, Cheetham ME, Hardcastle AJ and Webster AR
J Med Genet vol. 39 (1), 62-67.  
01-01-2002

Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3
CHAPPLE JP, Lewis SA, Willison KR, Bartolini F, Bhamidipati A and Grayson C
Hum Mol Genet vol. 11 (24), 3065-3074.  
01-01-2002

Identification and characterization of a human mitochondrial homologue of the bacterial co-chaperone GrpE
CHAPPLE JP, Cheetham ME, Blatch GL and Choglay AA
Gene vol. 267 (1), 125-134.  
01-01-2001

Unfolding retinal dystrophies: a role for molecular chaperones?
CHAPPLE JP, Grayson C, Saliba RS, Hardcastle AJ, Van Der SJ and Cheetham ME
Trends Mol Med vol. 7 (9), 414-421.  
01-01-2001

Mutations in the N-terminus of the X-linked retinitis pigmentosa protein RP2 interfere with the normal targeting of the protein to the plasma membrane
Chapple JP, Hardcastle AJ, Grayson C, Spackman LA, Willison KR and Cheetham ME
Human Molecular Genetics, Oxford University Press (Oup) vol. 9 (13), 1919-1926.  
12-08-2000

Assignment1 of the neuronal cochaperone, HSJ1, to human chromosome bands 2q32→q34 between D2S295 and D2S339 by in situ hybridization and somatic cell and radiation hybrids
Chapple JP, Hardcastle AJ, Kurzik-Dumke U, Collier DA and Cheetham ME
Cytogenetic and Genome Research, Karger Publishers vol. 86 (1), 62-63.  
01-01-1999

Seasonal changes in stress-70 protein levels reflect thermal tolerance in the marine bivalve Mytilus edulis L.
Chapple JP, Smerdon GR, Berry RJ and Hawkins AJS
Journal of Experimental Marine Biology and Ecology, Elsevier vol. 229 (1), 53-68.  
01-10-1998

Stress-70 protein induction in Mytilus edulis: Tissue-specific responses to elevated temperature reflect relative vulnerability and physiological function
Chapple JP, Smerdon GR and Hawkins AJS
Journal of Experimental Marine Biology and Ecology, Elsevier vol. 217 (2), 225-235.  
01-10-1997

The simultaneous immunological detection of four stress-70 protein isoforms in Mytilus edulis
Smerdon GR, Chapple JP and Hawkins AJS
Marine Environmental Research, Elsevier vol. 40 (4), 399-407.  
01-01-1995