Mcleod JC, Lim C, Stokes T, Sharif J-A, Zeynalli V, Wiens L, D’Souza AC, Colenso-Semple L, McKendry J, Morton RW, Mitchell CJ, Oikawa SY, Wahlestedt C, Chapple JP, McGlory C, Timmons JA and Phillips SM (2024). Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling. Oxford University Press (OUP)  NAR Molecular Medicine   

Ozkan-Nikitaras T, Grzesik DJ, Romano LEL, Chapple JP, King PJ and Shoulders CC (2024). N-SREBP2 Provides a Mechanism for Dynamic Control of Cellular Cholesterol Homeostasis. MDPI  Cells  vol. 13, (15)  

Marszalek J, De Los Rios P, Cyr D, Mayer MP, Adupa V, Andréasson C, Blatch GL, Braun JEA, Brodsky JL, Bukau B, Chapple JP, Conz C, Dementin S, Genevaux P, Genest O, Goloubinoff P, Gestwicki J, Hammond CM, Hines JK, Ishikawa K, Joachimiak LA, Kirstein J, Liberek K, Mokranjac D, Nillegoda N, Ramos CHI, Rebeaud M, Ron D, Rospert S and Sahi C (2023). J-domain proteins: From molecular mechanisms to diseases. Elsevier  Cell Stress and Chaperones  vol. 29, (1) 21-33.  

Perna L, Castelli M, Frasnetti E, Romano LEL, Colombo G, Prodromou C and Chapple JP (2023). AlphaFold predicted structure of the Hsp90-like domains of the neurodegeneration linked protein sacsin reveals key residues for ATPase activity. Frontiers  Frontiers in Molecular Biosciences  vol. 9,  

Prodromou C, Aran-Guiu X, Oberoi J, Perna L, Chapple JP and van der Spuy J (2022). HSP70-HSP90 Chaperone Networking in Protein-Misfolding Disease. Springer Nature  Subcellular Biochemistry  vol. 101, 389-425.  

Romano LEL, Aw WY, Hixson KM, Novoselova TV, Havener TM, Howell S, Taylor-Blake B, Hall CL, Xing L, Beri J, Nethisinghe S, Perna L, Hatimy A, Altadonna GC, Graves LM, Herring LE, Hickey AJ, Thalassinos K, Chapple JP and Wolter JM (2022). Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization. Elsevier  Cell Reports  vol. 41, (5)  

Tufton N, Hearnden RJ, Berney DM, Drake WM, Parvanta L, Chapple JP and Akker SA (2022). The immune cell infiltrate in the tumour microenvironment of phaeochromocytomas and paragangliomas. Bioscientifica  Endocrine Related Cancer  vol. 29, (11) 589-598.  

Sladen PE, Jovanovic K, Guarascio R, Ottaviani D, Salsbury G, Novoselova T, Chapple JP, Yu-Wai-Man P and Cheetham ME (2022). Modelling autosomal dominant optic atrophy associated with OPA1 variants in iPSC-derived retinal ganglion cells. Oxford University Press (OUP)  Human Molecular Genetics  vol. 31, (20) 3478-3493.  

Meireles CG, Lourenço de Lima C, Martins de Paula Oliveira M, Abe da Rocha Miranda R, Romano L, Yo-Stella Brashaw T, Neves da Silva Guerra E, de Assis Rocha Neves F, Chapple JP, Simeoni LA and Lofrano-Porto A (2021). Antiproliferative effects of metformin in cellular models of pheochromocytoma. Elsevier  Molecular and Cellular Endocrinology  vol. 539,  

Sladen PE, Perdigão PRL, Salsbury G, Novoselova T, van der Spuy J, Chapple JP, Yu-Wai-Man P and Cheetham ME (2021). CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs. Elsevier  Molecular Therapy - Nucleic Acids  vol. 26, 432-443.  

Callender LA, Schroth J, Carroll EC, Garrod-Ketchley C, Romano LEL, Hendy E, Kelly A, Lavender P, Akbar AN, Chapple JP and Henson S (2021). GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage. Nature Research (part of Springer Nature)  Nature Communications   

Thompson C, Mcfie M, Chapple J, BEALES P and Knight M (2021). Polycystin-2 is required for chondrocyte mechanotransduction and traffics to the primary cilium in response to mechanical stimulation. MDPI AG  International Journal of Molecular Sciences   

Desai R, East DA, Hardy L, Faccenda D, Rigon M, Crosby J, Alvarez MS, Singh A, Mainenti M, Hussey LK, Bentham R, Szabadkai G, Zappulli V, Dhoot GK, Romano LE, Xia D, Coppens I, Hamacher-Brady A, Chapple JP, Abeti R, Fleck RA, Vizcay-Barrena G, Smith K and Campanella M (2020). Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response. American Association for the Advancement of Science (AAAS)  Science Advances  vol. 6, (51)  

Athanasiou D, Bevilacqua D, Aguila M, McCulley C, Kanuga N, Iwawaki T, Chapple JP and Cheetham ME (2020). Corrigendum to: The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control. Oxford University Press (OUP)  Human Molecular Genetics  vol. 29, (19) 3338-3339.  

O’Toole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM, Sharp TV, Barnes MR, Srirangalingam U, Drake WM and Chapple JP (2019). Oncometabolite induced primary cilia loss in pheochromocytoma. Endocrine-Related Cancer  vol. 26, (1) 165-180.  

Costa ARD, Qarin S, Bradshaw T, Watson D, Prasad R, Metherell LA, Barnes MR, Skarnes W, Chapple JP and Storr HL (2018). Can novel stem cell models help unpick the pathogenesis of the Triple A syndrome? Bioscientifica  Endocrine Abstracts   

Gentil BJ, Lai G-T, Menade M, Larivière R, Minotti S, Gehring K, Chapple J-P, Brais B and Durham HD (2018). Sacsin, mutated in the ataxia ARSACS, regulates intermediate filament assembly and dynamics. Wiley  The FASEB Journal  vol. 33, (2) 2982-2994.  

Parkinson MH, Bartmann AP, Clayton LMS, Nethisinghe S, Pfundt R, Chapple JP, Reilly MM, Manji H, Wood NJ, Bremner F and Giunti P (2018). Optical coherence tomography in autosomal recessive spastic ataxia of Charlevoix-Saguenay. Oxford University Press (OUP)  Brain  vol. 141, (4) 989-999.  

Da CAR, Meimaridou E, Prasad R, Metherell LA, Chapple JP and Storr HL (2017). Novel evidence implies that ALADIN, the triple A syndrome gene product is involved in mitochondrial physiology. Bioscientifica  Endocrine Abstracts   

Thompson CL, Plant JC, Wann AK, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP and Knight MM (2017). Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling. Eur Cell Mater  vol. 34, 128-141.  

Zhang J, Dalbay MT, Luo X, Vrij E, Barbieri D, Moroni L, de Bruijn JD, van Blitterswijk CA, Chapple JP, Knight MM and Yuan H (2017). Topography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis. Acta Biomater  vol. 57, 487-497.  

CHAPPLE JP (2017). Altered organisation of the intermediate filament cytoskeleton and relocalisation of proteostasis modulators in cells lacking the ataxia protein sacsin. Oxford University Press  Human Molecular Genetics   

Schwarz N, Lane A, Jovanovic K, Parfitt DA, Aguila M, Thompson CL, da Cruz L, Coffey PJ, Chapple JP, Hardcastle AJ and Cheetham ME (2017). Arl3 and RP2 regulate the trafficking of ciliary tip kinesins. Oxford University Press  Hum Mol Genet  vol. 26, (13) 2480-2492.  

Schwarz N, Lane A, Jovanovic K, Parfitt DA, Aguila M, Thompson CL, da Cruz L, Coffey PJ, Chapple JP, Hardcastle AJ and Cheetham ME (2017). Arl3 and RP2 regulate the trafficking of ciliary tip kinesins. (CORRIGENDUM). Oxford University Press  Hum Mol Genet  vol. 26, (17) 3451-3451.  

O'Toole SM and Chapple JP (2016). Primary cilia: a link between hormone signalling and endocrine-related cancers? Portland Press  Biochemical Society Transactions  vol. 44, (5) 1227-1234.  

CHAPPLE JP, Bradshaw TY, Romano LEL, Duncan EJ, Nethisinghe S, Abeti R, Michael GJ, Giunti P and Vermeer S (2016). A reduction in Drp1 mediated fission compromises mitochondrial health in autosomal recessive spastic ataxia of Charlevoix Saguenay. Oxford University Press (OUP): Policy B - Oxford Open Option B  Human Molecular Genetics  vol. 25, (15) 3232-3244.  

O'Toole S, Srirangalingam U, Drake W and Chapple JP (2016). The role of primary cilia in the molecular pathogenesis of phaeochromocytoma. Bioscientifica  Endocrine Abstracts   

Thompson CL, Patel R, Kelly T-AN, Wann AKT, Hung CT, Chapple JP and Knight MM (2015). Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β. Arthritis Research & Therapy  vol. 17, (1)  

Dalbay MT, Thorpe SD, Connelly JT, Chapple JP and Knight MM (2015). Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF‐1r Onto the Primary Cilium Associated With Cilia Elongation. Oxford University Press (OUP)  Stem Cells  vol. 33, (6) 1952-1961.  

Blumkin L, Bradshaw T, Michelson M, Kopler T, Dahari D, Lerman-Sagie T, Lev D, Chapple JP and Leshinsky-Silver E (2015). Molecular and functional studies of retinal degeneration as a clinical presentation of SACS-related disorder. Elsevier  European Journal of Paediatric Neurology  vol. 19, (4) 472-476.  

Thompson CL, Wann AKT, Chapple JP, Poole CA and Knight MM (2015). Competitive interactions between hedgehog and cytokine signalling: crosstalk at the chondrocyte primary cilium? INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY  vol. 96, (2) A8-A8.  

Athanasiou D, Bevilacqua D, Aguila M, McCulley C, Kanuga N, Iwawaki T, Chapple JP and Cheetham ME (2014). The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control. Hum Mol Genet  vol. 23, (24) 6594-6606.  

Duncan EJ, Cheetham ME, Chapple JP and van der Spuy J (2014). The Role of HSP70 and Its Co-chaperones in Protein Misfolding, Aggregation and Disease. Springer Nature  Subcellular Biochemistry  vol. 78, 243-273.  

Wann AKT, Chapple JP and Knight MM (2014). The primary cilium influences interleukin-1β-induced NFκB signalling by regulating IKK activity. Cell Signal  vol. 26, (8) 1735-1742.  

Thompson CL, Chapple JP and Knight MM (2014). Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes. Osteoarthritis Cartilage  vol. 22, (3) 490-498.  

Wann AK, Thompson CL, Chapple JP and Knight MM (2013). Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. Cilia  vol. 2, (1)  

Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL and Metherell LA (2013). Familial glucocorticoid deficiency: New genes and mechanisms. Mol Cell Endocrinol  vol. 371, (1-2) 195-200.  

Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL and Metherell LA (2013). Familial glucocorticoid deficiency: New genes and mechanisms. Molecular and Cellular Endocrinology  vol. 371, (1-2) 195-200.  

Prodromou NV, Thompson CL, Osborn DPS, Cogger KF, Ashworth R, Knight MM, Beales PL and Chapple JP (2012). Heat shock induces rapid resorption of primary cilia. The Company of Biologists  Development  vol. 139, (24) e2408-e2408.  

Prodromou NV, Thompson CL, Osborn DPS, Cogger KF, Ashworth R, Knight MM, Beales PL and Chapple JP (2012). Heat shock induces rapid resorption of primary cilia. Journal of Cell Science  vol. 125, (18) 4297-4305.  

Thompson C, Prodromou N, Osborn D, Ashworth R, Knight M, Beales P and Chapple J (2012). Heat-shock induces rapid resorption of primary cilia. Springer Nature  Cilia  vol. 1, (Suppl 1)  

Thompson C, Chapple J and Knight M (2012). Mechanical strain disrupts primary cilia structure and modulates hedgehog signalling in adult chondrocytes. Springer Nature  Cilia  vol. 1, (Suppl 1)  

Athanasiou D, Kosmaoglou M, Kanuga N, Novoselov SS, Paton AW, Paton JC, Chapple JP and Cheetham ME (2012). BiP prevents rod opsin aggregation. Mol Biol Cell  vol. 23, (18) 3522-3531.  

Chahal HS, Trivellin G, Leontiou CA, Alband N, Fowkes RC, Tahir A, Igreja SC, Chapple JP, Jordan S, Lupp A, Schulz S, Ansorge O, Karavitaki N, Carlsen E, Wass JAH, Grossman AB and Korbonits M (2012). Somatostatin analogs modulate AIP in somatotroph adenomas: the role of the ZAC1 pathway. J Clin Endocrinol Metab  vol. 97, (8) E1411-E1420.  

Meimaridou E, Kowalczyk J, Guasti L, Hughes CR, Wagner F, Frommolt P, Nürnberg P, Mann NP, Banerjee R, Saka HN, Chapple JP, King PJ, Clark AJL and Metherell LA (2012). Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency. Nat Genet  vol. 44, (7) 740-742.  

Girard M, Lariviere R, Parfitt DA, Deane EC, Gaudet R, Nossova N, Blondeau F, Prenosil G, Vermeulen EGM, Duchen MR, Richter A, Shoubridge EA, Gehring K, McKinney RA, Brais B, Chapple JP and McPherson PS (2012). Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  vol. 109, (5) 1661-1666.  

Chapple JP, Parfitt DA and Campbell DC (2012). Hsp70 Chaperone Systems in Vesicular Trafficking. Cellular Trafficking of Cell Stress Proteins in Health and Disease  Springer Nature   

Thompson CL, Prodromou NV, Osborn DP, Ashworth R, Knight MM, Beales PL and Chapple JP (2012). Heat-shock induces rapid resorption of primary cilia. Cilia  vol. 1, (Suppl 1) P52-P52.  

Meimaridou E, Gooljar SB, Ramnarace N, Anthonypillai L, Clark AJL and Chapple JP (2011). The cytosolic chaperone Hsc70 promotes traffic to the cell surface of intracellular retained melanocortin-4 receptor mutants. Mol Endocrinol  vol. 25, (9) 1650-1660.  

Nethisinghe S, Clayton L, Vermeer S, Chapple JP, Reilly M, Bremner F and Giunti P (2011). Retinal Imaging in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay. NEURO-OPHTHALMOLOGY  vol. 35, (4) 197-201.  

Igreja S, Chahal HS, King P, Bolger GB, Srirangalingam U, Guasti L, Chapple JP, Trivellin G, Gueorguiev M, Guegan K, Stals K, Khoo B, Kumar AV, Ellard S, Grossman AB, Korbonits M and International FIPA Consortium (2010). Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families. Hum Mutat  vol. 31, (8) 950-960.  

Chahal HS, Chapple JP, Frohman LA, Grossman AB and Korbonits M (2010). Clinical, genetic and molecular characterization of patients with familial isolated pituitary adenomas (FIPA). Trends Endocrinol Metab  vol. 21, (7) 419-427.  

Wilkins S, Choglay AA, Chapple JP, van der Spuy J, Rhie A, Birkett CR and Cheetham ME (2010). The binding of the molecular chaperone Hsc70 to the prion protein PrP is modulated by pH and copper. Elsevier  The International Journal of Biochemistry & Cell Biology  vol. 42, (7) 1226-1232.  

Storr HL, Kind B, Parfitt DA, Chapple JP, Lorenz M, Koehler K, Huebner A and Clark AJL (2009). Deficiency of ferritin heavy-chain nuclear import in triple a syndrome implies nuclear oxidative damage as the primary disease mechanism. Mol Endocrinol  vol. 23, (12) 2086-2094.  

Sen Gupta P, Prodromou NV and Chapple JP (2009). Can faulty antennae increase adiposity? The link between cilia proteins and obesity. J Endocrinol  vol. 203, (3) 327-336.  

Storr HL, Kind B, Parfitt DA, Chapple JP, Lorenz M, Koehler K, Huebner A and Clark AJL (2009). Deficiency of Ferritin Heavy-Chain Nuclear Import in Triple A Syndrome Implies Nuclear Oxidative Damage as the Primary Disease Mechanism. The Endocrine Society  The Journal of Clinical Endocrinology & Metabolism  vol. 94, (11) 4626-4626.  

Parfitt DA, Michael GJ, Vermeulen EGM, Prodromou NV, Webb TR, Gallo J-M, Cheetham ME, Nicoll WS, Blatch GL and Chapple JP (2009). The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1. Hum Mol Genet  vol. 18, (9) 1556-1565.  

Chan LF, Webb TR, Chung T-T, Meimaridou E, Cooray SN, Guasti L, Chapple JP, Egertová M, Elphick MR, Cheetham ME, Metherell LA and Clark AJL (2009). MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. Proc Natl Acad Sci U S A  vol. 106, (15) 6146-6151.  

Webb TR, Chan L, Cooray SN, Cheetham ME, Chapple JP and Clark AJL (2009). Distinct melanocortin 2 receptor accessory protein domains are required for melanocortin 2 receptor interaction and promotion of receptor trafficking. Endocrinology  vol. 150, (2) 720-726.  

Meimaridou E, Gooljar SB and Chapple JP (2009). From hatching to dispatching: the multiple cellular roles of the Hsp70 molecular chaperone machinery. J Mol Endocrinol  vol. 42, (1) 1-9.  

Chapple JP, Bros-Facer V, Butler R and Gallo JM (2008). Focal distortion of the nuclear envelope by huntingtin aggregates revealed by lamin immunostaining. NEUROSCI LETT  vol. 447, (2-3) 172-174.  

Chung TT, Webb TR, Chan LF, Cooray SN, Metherell LA, King PJ, Chapple JP and Clark AJL (2008). The majority of adrenocorticotropin receptor (melanocortin 2 receptor) mutations found in familial glucocorticoid deficiency type 1 lead to defective trafficking of the receptor to the cell surface. J Clin Endocrinol Metab  vol. 93, (12) 4948-4954.  

Leontiou CA, Gueorguiev M, van der Spuy J, Quinton R, Lolli F, Hassan S, Chahal HS, Igreja SC, Jordan S, Rowe J, Stolbrink M, Christian HC, Wray J, Bishop-Bailey D, Berney DM, Wass JAH, Popovic V, Ribeiro-Oliveira A, Gadelha MR, Monson JP, Akker SA, Davis JRE, Clayton RN, Yoshimoto K, Iwata T, Matsuno A, Eguchi K, Musat M, Flanagan D and Peters G (2008). The role of the aryl hydrocarbon receptor-interacting protein gene in familial and sporadic pituitary adenomas. J Clin Endocrinol Metab  vol. 93, (6) 2390-2401.  

Cooray SN, Almiro Do Vale I, Leung K-Y, Webb TR, Chapple JP, Egertová M, Cheetham ME, Elphick MR and Clark AJL (2008). The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line. Endocrinology  vol. 149, (4) 1935-1941.  

CHAPPLE JP, Gallo JM, Cooper TA, Dev A, Martin TR and Anthony K (2007). Expression, localization and Tau Exon 10 splicing activity of the brain RNA-binding protein TNRC4. Human Molecular Genetics  vol. 16, (22) 2760-2769.  

CHAPPLE JP, Dev A, Anthony K, Cooper TA, Rodriguez-Martin T and Gallo J-M (2007). Expression, localization and tau exon 10 splicing activity of the brain RNA-binding protein TNRC4. Human Molecular Genetics  vol. 16, (22) 2760-2769.  

Howarth JL, Kelly S, Keasey MP, Glover CPJ, Lee YB, Mitrophanous K, Chapple JP, Gallo JM, Cheetham ME and Uney JB (2007). Hsp40 molecules that target to the ubiquitin-proteasome system decrease inclusion formation in models of polyglutamine disease. MOL THER  vol. 15, (6) 1100-1105.  

Howarth JL, Kelly S, Keasey MP, Glover C, Lee Y-B, Mitrophanous K, Chapple JP, Gallo JM, Cheetham ME and Uney JB (2007). Hsp40 Molecules That Target to the Ubiquitin-proteasome System Decrease Inclusion Formation in Models of Polyglutamine Disease. Mol Ther  vol. 15, (6) 1100-1105.  

Hooper C, Chapple JP, Lovestone S and Killick R (2007). The Notch-1 intracellular domain is found in sub-nuclear bodies in SH-SY5Y neuroblastomas and in primary cortical neurons. NEUROSCI LETT  vol. 415, (2) 135-139.  

Nicoll WS, Botha M, McNamara C, Schlange M, Pesce ER, Boshoff A, Ludewig MH, Zimmermann R, Cheetham ME, Chapple JP and Blatch GL (2007). Cytosolic and ER J-domains of mammalian and parasitic origin can functionally interact with DnaK. INT J BIOCHEM CELL B  vol. 39, (4) 736-751.  

Hooper C, Tavassoli M, Chapple JP, Uwanogho D, Goodyear R, Melino G, Lovestone S and Killick R (2006). TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones. J NEUROCHEM  vol. 99, (3) 989-999.  

Storr H, Koehler K, Huebner A, Chapple JP and Clark AJL (2006). A candidate interacting protein for the nuclear pore protein ALADIN: a potential pathogenic mechanism for the triple A syndrome. HORM RES  vol. 65, 16-16.  

CHAPPLE JP, Adamson P, Matter K, Bailey TA, Hardcastle AJ and Grayson C (2006). Organization on the plasma membrane of the retinitis pigmentosa protein RP2: investigation of association with detergent-resistant membranes and polarized sorting. Biochem J  vol. 372, (pt 2) 427-433.  

Ross AJ, May-Simera H, Eichers ER, Kai M, Hill J, Jagger DJ, Leitch CC, Chapple JP, Munro PM, Fisher S, Tan PL, Phillips HM, Leroux MR, Henderson DJ, Murdoch JN, Copp AJ, Eliot M-M, Lupski JR, Kemp DT, Dollfus H, Tada M, Katsanis N, Forge A and Beales PL (2005). Erratum: Corrigendum: Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Springer Nature  Nature Genetics  vol. 37, (12) 1381-1381.  

CHAPPLE JP, Fisher S, Tan PL, Phillips HM, Leitch CC, Eliot MM, Copp AJ, Katsanis N, Dollfus H, Kemp DT, Tada M, Ross AJ, May-Simera H, Eichers ER, Kai M, Forge A, Beales PL, Leroux MR, Murdoch JN, Henderson DJ, Munro PM, Jagger DJ, Hill J and Lupski JR (2005). Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nature Genetics  vol. 37, (10) 1135-1140.  

CHAPPLE JP, Cheetham ME, Westhoff B, Van Der Spuy SJ and Hohfeld J (2005). HSJ1 Is a Neuronal Shuttling Factor for the Sorting of Chaperone Clients to the Proteasome. Current Biology  vol. 15, (11) 1058-1064.  

David A, CHAPPLE JP, Cooray S, Metherell LA, Ruschendorf F and Becker C (2005). Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2. Nature Genetics  vol. 37, (2) 166-170.  

CHAPPLE JP, Cheetham ME, Van Der SJ and Mendes HF (2005). Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy. Trends Mol Med  vol. 11, (4) 177-185.  

CHAPPLE JP, Banerjee R, Gaasenbeek M, Cheetham ME, Ocaka L and Inglis-Broadgate SL (2005). Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2. Gene  vol. 356, 19-31.  

Evans RJ, Chapple JP, Grayson C, Hardcastle AJ and Cheetham ME (2005). Assay and functional analysis of the ARL3 effector RP2 involved in X-linked retinitis pigmentosa. Methods Enzymol  vol. 404, 468-480.  

Longshaw VM, Chapple JP, Balda MS, Cheetham ME and Blatch GL (2004). Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases. The Company of Biologists  Journal of Cell Science  vol. 117, (5) 701-710.  

CHAPPLE JP, Holder GE, Egan CA, Grayson C, Dandekar SS and Ebenezer ND (2004). An atypical phenotype of macular and peripapillary retinal atrophy caused by a mutation in the RP2 gene. Br. J Opthalmol  vol. 88, (4) 528-532.  

CHAPPLE JP, Cheetham ME, Poopalasundaram S and Van Der SJ (2004). Neuronal DnaJ proteins HSJ1a and HSJ1b: a role in linking the Hsp70 chaperone machine to the ubiquitin-proteasome system? Biochem Soc Trans  vol. 32, (pt4) 640-642.  

CHAPPLE JP, Cheetham ME, Blatch GL, Longshaw VM and Balda MS (2004). Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases. J Cell Sci  vol. 117, (pt 5) 701-710.  

Chapple JP and Cheetham ME (2003). The chaperone environment at the cytoplasmic face of the endoplasmic reticulum can modulate rhodopsin processing and inclusion formation. J Biol Chem  vol. 278, (21) 19087-19094.  

CHAPPLE JP and Cheetham ME (2003). The Chaperone Environment at the Cytoplasmic Face of the Endoplasmic Reticulum Can Modulate Rhodopsin Processing and Inclusion Formation. Journal of Biological Chemistry  vol. 278, (21) 19087-19094.  

Chapple JP, Hardcastle AJ, Grayson C, Willison KR and Cheetham ME (2002). Delineation of the plasma membrane targeting domain of the X-linked retinitis pigmentosa protein RP2. Invest Ophthalmol Vis Sci  vol. 43, (6) 2015-2020.  

van der Spuy J, Chapple JP, Clark BJ, Luthert PJ, Sethi CS and Cheetham ME (2002). The Leber congenital amaurosis gene product AIPL1 is localized exclusively in rod photoreceptors of the adult human retina. Hum Mol Genet  vol. 11, (7) 823-831.  

CHAPPLE JP, Willison KR, Grayson C, Cheetham ME, Hardcastle AJ and Webster AR (2002). In vitro analysis of aminoglycoside therapy for the Arg120stop nonsense mutation in RP2 patients. J Med Genet  vol. 39, (1) 62-67.  

CHAPPLE JP, Lewis SA, Willison KR, Bartolini F, Bhamidipati A and Grayson C (2002). Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3. Hum Mol Genet  vol. 11, (24) 3065-3074.  

CHAPPLE JP, Cheetham ME, Blatch GL and Choglay AA (2001). Identification and characterization of a human mitochondrial homologue of the bacterial co-chaperone GrpE. Gene  vol. 267, (1) 125-134.  

CHAPPLE JP, Grayson C, Saliba RS, Hardcastle AJ, Van Der SJ and Cheetham ME (2001). Unfolding retinal dystrophies: a role for molecular chaperones? Trends Mol Med  vol. 7, (9) 414-421.  

Chapple JP, Hardcastle AJ, Grayson C, Spackman LA, Willison KR and Cheetham ME (2000). Mutations in the N-terminus of the X-linked retinitis pigmentosa protein RP2 interfere with the normal targeting of the protein to the plasma membrane. Oxford University Press (OUP)  Human Molecular Genetics  vol. 9, (13) 1919-1926.  

Chapple JP, Hardcastle AJ, Kurzik-Dumke U, Collier DA and Cheetham ME (1999). Assignment1 of the neuronal cochaperone, HSJ1, to human chromosome bands 2q32→q34 between D2S295 and D2S339 by in situ hybridization and somatic cell and radiation hybrids. Karger Publishers  Cytogenetic and Genome Research  vol. 86, (1) 62-63.  

Chapple JP, Smerdon GR, Berry RJ and Hawkins AJS (1998). Seasonal changes in stress-70 protein levels reflect thermal tolerance in the marine bivalve Mytilus edulis L. Elsevier  Journal of Experimental Marine Biology and Ecology  vol. 229, (1) 53-68.  

Chapple JP, Smerdon GR and Hawkins AJS (1997). Stress-70 protein induction in Mytilus edulis: Tissue-specific responses to elevated temperature reflect relative vulnerability and physiological function. Elsevier  Journal of Experimental Marine Biology and Ecology  vol. 217, (2) 225-235.  

Smerdon GR, Chapple JP and Hawkins AJS (1995). The simultaneous immunological detection of four stress-70 protein isoforms in Mytilus edulis. Elsevier  Marine Environmental Research  vol. 40, (4) 399-407.