Prof Paul Evans

Paul Evans

Professor of Vascular Metabolism

The William Harvey Research Institute
Queen Mary University of London
07825 611695
www.paulevanslab.com/
ORCID Google Scholar X

Research

shear stress, endothelial, atherosclerosis

Cardiovascular Models

Interests

The Evans Lab focusses on the intricate biology of endothelial cells, the vital lining of blood vessels. Our primary focus lies in unraveling the mechanisms by which these cells react to the mechanical forces induced by the circulation of blood. Specifically, we use in vitro flow systems to explore the connection between endothelial responses to shear stress and the development of atherosclerosis. This disease, responsible for heart attacks and strokes, stands as a significant contributor to mortality and disability.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2024

Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation
Bowley G, Irving S, Hoefer I, Wilkinson R, Pasterkamp G, Darwish HMS, White S, Francis SE, Chico T, Noel E, Serbanovic-Canic J and Evans PC
Scientific Reports, Springer Nature vol. 14 (1) 
03-12-2024
Correction: Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents
Boldock L, Inzoli A, Bonardelli S, Hsiao S, Marzo A, Narracott A, Gunn J, Dubini G, Chiastra C, Halliday I, Morris PD, Evans PC and C M P
Plos One, Public Library of Science (Plos) vol. 19 (11) 
19-11-2024
Shear stress is uncoupled from atheroprotective KLK10 in atherosclerotic plaques
Zhou Z, Korteland S-A, Tardajos-Ayllon B, Wu J, Chambers E, Weninck J, Simons M, Dunning M, Schenkel T, Diagbouga M, Wentzel J, Fragiadaki M and Evans PC
Atherosclerosis, Elsevier vol. 398 
04-10-2024
EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake
Pirri D, Tian S, Tardajos-Ayllon B, Irving SE, Donati F, Allen SP, Mammoto T, Vilahur G, Kabir L, Bennett J, Rasool Y, Pericleous C, Mazzei G, McAllan L, Scott WR, Koestler T, Zingg U, Birdsey GM, Miller CL, Schenkel T, Chambers EV, Dunning MJ, Serbanovic-Canic J, Botrè F, Mammoto A, Xu S, Osto E, Han W, Fragiadaki M and Evans PC
Circulation Research, Wolters Kluwer vol. 135 (8), 822-837.  
05-09-2024
Controversy in mechanotransduction – the role of endothelial cell–cell junctions in fluid shear stress sensing
X S, Aitken C, Mehta V, Tardajos-Ayllon B, Serbanovic-Canic J, Zhu J, Miao B, Tzima E, Evans P, Fang Y and Schwartz MA
Journal of Cell Science, The Company of Biologists vol. 137 (17) 
01-09-2024
Anthocyanins in Vascular Health and Disease: Mechanisms of Action and Therapeutic Potential
Zhao Y, Wang L, Huang Y, Evans PC, Little PJ, Tian X, Weng J and Xu S
Journal of Cardiovascular Pharmacology, Wolters Kluwer vol. 84 (3), 289-302.  
01-09-2024
BMPER regulates arterial adaptation to flow
Tian S and Evans PC
Nature Cardiovascular Research, Springer Nature vol. 3 (7), 777-779.  
01-07-2024
Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E–deficient mice
Xu M-Y, Xu J-J, Kang L-J, Liu Z-H, Su M-M, Zhao W-Q, Wang Z-H, Sun L, Xiao J-B, Evans PC, Tian X-Y, Wang L, Huang Y, Liang X-M, Weng J-P and Xu S-W
Acta Pharmacologica Sinica, Springer Nature vol. 45 (11), 2277-2289.  
17-06-2024
Sex-related differences in coronary and carotid vessel geometry, plaque composition and shear stress obtained from imaging
Wentzel JJ, Bos D, White SJ, van der Heiden K, Kavousi M and Evans PC
Atherosclerosis, Elsevier vol. 395 
06-06-2024
Assessing friction and damage of cell monolayers on soft substrates in vitro
Wagner R, Carré MJ, Perrault CM, Evans PC and Lewis R
Journal of The Royal Society Interface, The Royal Society vol. 21 (215) 
01-06-2024
NAFLD and NASH: etiology, targets and emerging therapies
Wei S, Wang L, Evans PC and Xu S
Drug Discovery Today, Elsevier vol. 29 (3) 
01-02-2024

2023

Editorial overview: Recent insights into the multifaceted physiology of the endothelial cell and its modulated functions in pathology
Evans PC and Pearson J
Current Opinion in Physiology, Elsevier vol. 36 
01-12-2023
Editorial: Endothelial-to-mesenchymal transition in cardiovascular disease
Alfaidi M, Evans PC and Pickering JG
Frontiers in Cardiovascular Medicine, Frontiers vol. 10 
12-10-2023
Correction to: EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy

Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 43 (6), e230-e230.  
24-05-2023
DLL4 promotes partial endothelial-to-mesenchymal transition at atherosclerosis-prone regions of arteries
Li X, Souilhol C, Canham L, Jia X, Diagbouga M, Ayllon BT, Serbanovic-Canic J and Evans PC
Vascular Pharmacology, Elsevier vol. 150 
01-05-2023
EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy
Canham L, Sendac S, Diagbouga MR, Wolodimeroff E, Pirri D, Ayllon BT, Feng S, Souilhol C, Chico TJA, Evans PC and Serbanovic-Canic J
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 43 (4), 547-561.  
16-02-2023

2022

Translational opportunities of single-cell biology in atherosclerosis
de Winther MPJ, Bäck M, Evans P, Gomez D, Goncalves I, Jørgensen HF, Koenen RR, Lutgens E, Norata GD, Osto E, Dib L, Simons M, Stellos K, Ylä-Herttuala S, Winkels H, Bochaton-Piallat M-L and Monaco C
European Heart Journal, Oxford University Press (Oup) vol. 44 (14), 1216-1230.  
07-12-2022
JAG1-NOTCH4 mechanosensing drives atherosclerosis
Souilhol C, Ayllon BT, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ, Ariaans M, Li J, Fang Y, Jørgensen HF, Simons M, Krams R, Waltenberger J, Fragiadaki M, Ridger V, De Val S, Francis SE, Chico TJA, Serbanovic-Canic J and Evans PC
Science Advances, American Association For The Advancement of Science vol. 8 (35) 
02-09-2022
From novel discovery tools and biomarkers to precision medicine—basic cardiovascular science highlights of 2021/22
Evans PC, Davidson SM, Wojta J, Bäck M, Bollini S, Brittan M, Catapano AL, Chaudhry B, Cluitmans M, Gnecchi M, Guzik TJ, Hoefer I, Madonna R, Monteiro JP, Morawietz H, Osto E, Padró T, Sluimer JC, Tocchetti CG, Van der Heiden K, Vilahur G, Waltenberger J and Weber C
Cardiovascular Research, Oxford University Press (Oup) vol. 118 (13), 2754-2767.  
28-07-2022
Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents
Boldock L, Inzoli A, Bonardelli S, Hsiao S, Marzo A, Narracott A, Gunn J, Dubini G, Chiastra C, Halliday I, Morris PD, Evans PC and C M P
Plos One, Public Library of Science (Plos) vol. 17 (7) 
28-07-2022
Interpretation and actionability of genetic variants in cardiomyopathies: a position statement from the European Society of Cardiology Council on cardiovascular genomics
Arbustini E, Behr ER, Carrier L, van Duijn C, Evans P, Favalli V, van der Harst P, Haugaa KH, Jondeau G, Kääb S, Kaski JP, Kavousi M, Loeys B, Pantazis A, Pinto Y, Schunkert H, Di Toro A, Thum T, Urtis M, Waltenberger J and Elliott P
European Heart Journal, Oxford University Press (Oup) vol. 43 (20), 1901-1916.  
28-01-2022
A Workflow to Track and Analyze Endothelial Migration During Vascular Development in Zebrafish Embryos Using Lightsheet Microscopy
Chen Y, Evans PC and Wilkinson RN
In Angiogenesis, Springer Nature 19-28.  
01-01-2022

2021

Carbon Monoxide Releasing Molecule A1 Reduces Myocardial Damage After Acute Myocardial Infarction in a Porcine Model
Iqbal J, Chamberlain J, Alfaidi M, Hughes M, Alizadeh T, Casbolt H, Evans P, Mann B, Motterlini R, Francis S and Gunn J
Journal of Cardiovascular Pharmacology, Wolters Kluwer vol. 78 (5), e656-e661.  
01-11-2021
Scientists on the Spot: A matter of blood flow
Chiva-Blanch G and Evans PC
Cardiovascular Research, Oxford University Press (Oup) vol. 117 (12), e162-e163.  
29-10-2021
Quantifying endothelial cell proliferation in the zebrafish embryo
Bowley G, Chico TJ, Serbanovic-Canic J and Evans PC
F1000research, F1000research vol. 10 
11-10-2021
The effect of absent blood flow on the zebrafish cerebral and trunk vasculature
Kugler E, Snodgrass R, Bowley G, Plant K, Serbanovic-Canic J, Hamilton N, Evans PC, Chico T and Armitage P
Vascular Biology, Bioscientifica vol. 3 (1), 1-16.  
29-07-2021
Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart
Davidson SM, Padró T, Bollini S, Vilahur G, Duncker DJ, Evans PC, Guzik T, Hoefer IE, Waltenberger J, Wojta J and Weber C
Cardiovascular Research, Oxford University Press (Oup) vol. 117 (10), 2161-2174.  
11-06-2021
Resilience of the Internal Mammary Artery to Atherogenesis: Shifting From Risk to Resistance to Address Unmet Needs
Kraler S, Libby P, Evans PC, Akhmedov A, Schmiady MO, Reinehr M, Camici GG and Lüscher TF
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 41 (8), 2237-2251.  
10-06-2021
Erratum to: The year in basic vascular biology research: from mechanoreceptors and neutrophil extracellular traps to smartphone data and omics
Evans P, Wojta J, Hoefer IE, Waltenberger J, Guzik T and Badimon L
Cardiovascular Research, Oxford University Press (Oup) vol. 117 (9), 2107-2107.  
10-06-2021
Zebrafish as a tractable model of human cardiovascular disease
Bowley G, Kugler E, Wilkinson R, Lawrie A, van Eeden F, Chico TJA, Evans PC, Noël ES and Serbanovic‐Canic J
British Journal of Pharmacology, Wiley vol. 179 (5), 900-917.  
10-05-2021
Nrf2-Keap-1 imbalance under acute shear stress induces inflammatory response in venous endothelial cells
Ward AO, Sala-Newby GB, Ladak S, Angelini GD, Caputo M, Suleiman M-S, Evans PC, George SJ and Zakkar M
Perfusion, Sage Publications vol. 37 (6), 582-589.  
25-04-2021
The year in basic vascular biology research: from mechanoreceptors and neutrophil extracellular traps to smartphone data and omics
Evans P, Wojta J, Hoefer IE, Waltenberger J, Guzik T, Badimon L and Weber C
Cardiovascular Research, Oxford University Press (Oup) vol. 117 (8), 1814-1822.  
21-03-2021
Bio-tribology of Vascular Devices: A Review of Tissue/Device Friction Research
Wagner RMF, Maiti R, Carré MJ, Perrault CM, Evans PC and Lewis R
Biotribology, Elsevier vol. 25 
01-03-2021
Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling
An W, Luong LA, Bowden NP, Yang M, Wu W, Zhou X, Liu C, Niu K, Luo J, Zhang C, Sun X, Poston R, Zhang L, Evans PC and Xiao Q
Cardiovascular Research, Oxford University Press (Oup) vol. 118 (2), 638-653.  
18-02-2021
Endothelial NADPH oxidase 4 protects against angiotensin II‐induced cardiac fibrosis and inflammation
Wang M, Murdoch CE, Brewer AC, Ivetic A, Evans P, Shah AM and Zhang M
Esc Heart Failure, Wiley vol. 8 (2), 1427-1437.  
29-01-2021

2020

Shear stress: the dark energy of atherosclerotic plaques
Evans PC, Fragiadaki M, Morris PD and Serbanovic-Canic J
Cardiovascular Research, Oxford University Press (Oup) vol. 117 (8), 1811-1813.  
04-11-2020
NF-κB inhibition prevents acute shear stress-induced inflammation in the saphenous vein graft endothelium
Ward AO, Angelini GD, Caputo M, Evans PC, Johnson JL, Suleiman MS, Tulloh RM, George SJ and Zakkar M
Scientific Reports, Springer Nature vol. 10 (1) 
15-09-2020
Contemporary rationale for non-invasive imaging of adverse coronary plaque features to identify the vulnerable patient: a Position Paper from the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology and the European Association of Cardiovascular Imaging
Dweck MR, Maurovich-Horvat P, Leiner T, Cosyns B, Fayad ZA, Gijsen FJH, Van der Heiden K, Kooi ME, Maehara A, Muller JE, Newby DE, Narula J, Pontone G, Regar E, Serruys PW, van der Steen AFW, Stone PH, Waltenberger JL, Yuan C, Evans PC, Lutgens E, Wentzel JJ and Bäck M
European Heart Journal - Cardiovascular Imaging, Oxford University Press (Oup) vol. 21 (11), 1177-1183.  
04-09-2020
Diabetic atherosclerosis: is there a role for the hypoxia-inducible factors?
Pirri D, Fragiadaki M and Evans PC
Bioscience Reports, Portland Press vol. 40 (8) 
20-08-2020
Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science
Evans PC, Rainger GE, Mason JC, Guzik TJ, Osto E, Stamataki Z, Neil D, Hoefer IE, Fragiadaki M, Waltenberger J, Weber C, Bochaton-Piallat M-L and Bäck M
Cardiovascular Research, Oxford University Press (Oup) vol. 116 (14), 2177-2184.  
04-08-2020
A novel method for measuring absolute coronary blood flow and microvascular resistance in patients with ischaemic heart disease
Morris PD, Gosling R, Zwierzak I, Evans H, Aubiniere-Robb L, Czechowicz K, Evans PC, Hose DR, Lawford PV, Narracott AJ and Gunn JP
Cardiovascular Research, Oxford University Press (Oup) vol. 117 (6), 1567-1577.  
14-07-2020
Toll-like receptor 9 and the inflammatory response to surgical trauma and cardiopulmonary bypass
Naase H, Harling L, Kidher E, Sepehripour A, Nguyen B, Kapelouzou A, Cokkinos D, Stavridis G, Angelini G, Evans PC and Athanasiou T
Journal of Cardiothoracic Surgery, Springer Nature vol. 15 (1) 
11-06-2020
Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardiology Working Groups on Atherosclerosis and Vascular Biology, Aorta and Peripheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis
Alexander Y, Osto E, Schmidt-Trucksäss A, Shechter M, Trifunovic D, Duncker DJ, Aboyans V, Bäck M, Badimon L, Cosentino F, De Carlo M, Dorobantu M, Harrison DG, Guzik TJ, Hoefer I, Morris PD, Norata GD, Suades R, Taddei S, Vilahur G, Waltenberger J, Weber C, Wilkinson F, Bochaton-Piallat M-L and Evans PC
Cardiovascular Research, Oxford University Press (Oup) vol. 117 (1), 29-42.  
13-04-2020
Author Correction: Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail
Mahmoud MM, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis SE, Van der Heiden K, Ridger V and Evans PC
Scientific Reports, Springer Nature vol. 10 (1) 
26-02-2020
Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium
Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M, Luong LA, West L, Long M, Parry S, Woods R, Hulston C, Benedikter B, Niespolo C, Bazaz R, Francis S, Kiss-Toth E, van Zandvoort M, Schober A, Hellewell P, Evans PC and Ridger V
Nature Communications, Springer Nature vol. 11 (1) 
10-01-2020

2019

A particle-based model for endothelial cell migration under flow conditions
Zun PS, Narracott AJ, Evans PC, van Rooij BJM and Hoekstra AG
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 19 (2), 681-692.  
17-10-2019
Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications.
Gijsen F, Katagiri Y, Barlis P, Bourantas C, Collet C, Coskun U, Daemen J, Dijkstra J, Edelman E, Evans P, van der Heiden K, Hose R, Koo B-K, Krams R, Marsden A, Migliavacca F, Onuma Y, Ooi A, Poon E, Samady H, Stone P, Takahashi K, Tang D, Thondapu V, Tenekecioglu E, Timmins L, Torii R, Wentzel J and Serruys P
European Heart Journal, Oxford University Press (Oup) 
30-09-2019
Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites
Souilhol C, Gauci I, Feng S, Ayllon BT, Mahmoud M, Canham L, Fragiadaki M, Serbanovic-Canic J, Ridger V and Evans PC
Cardiovascular Research, Oxford University Press (Oup) vol. 116 (7), 1300-1310.  
29-08-2019
Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes
Souilhol C, Serbanovic-Canic J, Fragiadaki M, Chico TJ, Ridger V, Roddie H and Evans PC
Nature Reviews Cardiology, Springer Nature vol. 17 (1), 52-63.  
31-07-2019
Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology
Ketelhuth DFJ, Lutgens E, Bäck M, Binder CJ, Van den Bossche J, Daniel C, Dumitriu IE, Hoefer I, Libby P, O’Neill L, Weber C and Evans PC
Cardiovascular Research, Oxford University Press (Oup) vol. 115 (9), 1385-1392.  
22-06-2019
β1 integrin is a sensor of blood flow direction
Xanthis I, Souilhol C, Serbanovic-Canic J, Roddie H, Kalli AC, Fragiadaki M, Wong R, Shah DR, Askari JA, Canham L, Akhtar N, Feng S, Ridger V, Waltho J, Pinteaux E, Humphries MJ, Bryan MT and Evans PC
Journal of Cell Science, The Company of Biologists vol. 132 (11) 
01-06-2019
Shear stress makes its mark on the endothelial genome
Serbanovic-Canic J, Souilhol C and Evans PC
Cardiovascular Research, Oxford University Press (Oup) vol. 115 (10), 1449-1451.  
29-03-2019
Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo.
Baeriswyl DC, Prionisti I, Peach T, Tsolkas G, Chooi KY, Vardakis J, Morel S, Diagbouga MR, Bijlenga P, Cuhlmann S, Evans P, Kwak BR, Ventikos Y and Krams R
Sci Rep vol. 9 (1), 4738-4738.  
18-03-2019
GATA4-Twist1 Signalling in Disturbed Flow-Induced Atherosclerosis
Mahmoud M, Souilhol C, Serbanovic-Canic J and Evans P
Cardiovascular Drugs and Therapy, Springer Nature vol. 33 (2), 231-237.  
26-02-2019

2018

The Bernard and Joan Marshall Early Career Investigators and Distinguished Investigator Award 2018
Fragiadaki M and Evans PC
Cardiovascular Drugs and Therapy, Springer Nature vol. 33 (2), 203-205.  
14-12-2018
Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology
Tuñón J, Badimón L, Bochaton-Piallat M-L, Cariou B, Daemen MJ, Egido J, Evans PC, Hoefer IE, Ketelhuth DFJ, Lutgens E, Matter CM, Monaco C, Steffens S, Stroes E, Vindis C, Weber C and Bäck M
Cardiovascular Research, Oxford University Press (Oup) vol. 115 (1), 10-19.  
06-12-2018
The effect of the heart rate lowering drug Ivabradine on hemodynamics in atherosclerotic mice
Xing R, Moerman AM, Ridwan RY, Gaalen KV, Meester EJ, van der Steen AFW, Evans PC, Gijsen FJH and Van der Heiden K
Scientific Reports, Springer Nature vol. 8 (1) 
18-09-2018
Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology
Caporali A, Bäck M, Daemen MJ, Hoefer IE, Jones EA, Lutgens E, Matter CM, Bochaton-Piallat M-L, Siekmann AF, Sluimer JC, Steffens S, Tuñón J, Vindis C, Wentzel JJ, Ylä-Herttuala S and Evans PC
Cardiovascular Research, Oxford University Press (Oup) vol. 114 (11), 1411-1421.  
17-07-2018
Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL‐1–Mediated Mechanism
Alfaidi MA, Chamberlain J, Rothman A, Crossman D, Villa‐Uriol M, Hadoke P, Wu J, Schenkel T, Evans PC and Francis SE
Journal of The American Heart Association, Wolters Kluwer vol. 7 (13) 
30-06-2018
Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice
Tuñón J, Bäck M, Badimón L, Bochaton-Piallat M-L, Cariou B, Daemen MJ, Egido J, Evans PC, Francis SE, Ketelhuth DF, Lutgens E, Matter CM, Monaco C, Steffens S, Stroes E, Vindis C, Weber C and Hoefer IE
European Journal of Preventive Cardiology, Oxford University Press (Oup) vol. 25 (9), 948-955.  
14-05-2018
Notching Up Vascular Inflammation
Souilhol C and Evans PC
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 38 (4), 698-699.  
01-04-2018
Endothelial–mesenchymal transition in atherosclerosis
Souilhol C, Harmsen MC, Evans PC and Krenning G
Cardiovascular Research, Oxford University Press (Oup) vol. 114 (4), 565-577.  
04-01-2018

2017

Response by Feng et al to Letter Regarding Article, “Mechanical Activation of Hypoxia-Inducible Factor 1&agr; Drives Endothelial Dysfunction at Atheroprone Sites”
Feng S, Fragiadaki M, Souilhol C, Ridger V and Evans PC
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 37 (12), e199-e200.  
01-12-2017
Atheroprone flow activates inflammation via endothelial ATP-dependent P2X7-p38 signalling
Green JP, Souilhol C, Xanthis I, Martinez-Campesino L, Bowden NP, Evans PC and Wilson HL
Cardiovascular Research, Oxford University Press (Oup) vol. 114 (2), 324-335.  
06-11-2017
Mechanical Activation of Hypoxia-Inducible Factor 1&agr; Drives Endothelial Dysfunction at Atheroprone Sites
Feng S, Bowden N, Fragiadaki M, Souilhol C, Hsiao S, Mahmoud M, Allen S, Pirri D, Ayllon BT, Akhtar S, Thompson AAR, Jo H, Weber C, Ridger V, Schober A and Evans PC
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 37 (11), 2087-2101.  
07-09-2017
Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail
Mahmoud MM, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis SE, Van der Heiden K, Ridger V and Evans PC
Scientific Reports, Springer Nature vol. 7 (1) 
13-06-2017
169 Developing capture assays to measure circulating crp/oxidised low density lipoprotein complexes in patients undergoing cardiopulmonary bypass and examining use of crp/oxidised low density lipoprotein complexes as a biomarker of atherosclerosis
Mann P, Khamis RY, Haskard D, Ta M, Kojima C, Ammari T, Caga-Anan M, Nguyen BA, Anderson JR, Evans PC and Johns M
Heart, Bmj vol. 103 (Suppl 5) 
01-06-2017
Microvesicles in vascular homeostasis and diseases
Ridger VC, Boulanger CM, Angelillo-Scherrer A, Badimon L, Blanc-Brude O, Bochaton-Piallat M-L, Boilard E, Buzas EI, Caporali A, Dignat-George F, Evans PC, Lacroix R, Lutgens E, Ketelhuth DFJ, Nieuwland R, Toti F, Tuñon J, Weber C, Hoefer IE, Lip GYH, Werner N, Shantsila E, ten Cate H, Thomas M and Harrison P
Thrombosis and Haemostasis, Thieme vol. 117 (07), 1296-1316.  
01-01-2017
Consumption of Broccoli Sprouts Attenuates Intracellular P38 Map Kinase and Reactive Oxygen Species Pro-Inflammatory Activation in Human Leukocytes: A Randomised- Controlled Trial
Nguyen BA, McDonald G, Fiorentino F, Reeves BC, Kwak J, Pyo S, Angelini GD, Anderson JR, Frost G, Haskard DO and Evans PC
Journal of Clinical Nutrition & Dietetics, Omics International vol. 3 (4) 
01-01-2017

2016

Zebrafish Model for Functional Screening of Flow-Responsive Genes.
Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C, Bowden N, Ashton J-P, Walczak H, Firmin D, Krams R, Mason JC, Haskard DO, Sherwin S, Ridger V, Chico TJA and Evans PC
Arterioscler Thromb Vasc Biol, Wolters Kluwer Health, Inc vol. 37 (1), 130-143.  
10-11-2016
Reply
Nguyen B, Reeves B, Angelini G, Haskard D and Evans P
The Annals of Thoracic Surgery, Elsevier vol. 102 (5), 1765-1766.  
01-11-2016
Endothelial repair in stented arteries is accelerated by inhibition of Rho-associated protein kinase
Hsiao ST, Spencer T, Boldock L, Prosseda SD, Xanthis I, Tovar-Lopez FJ, Van Beusekom HMM, Khamis RY, Foin N, Bowden N, Hussain A, Rothman A, Ridger V, Halliday I, Perrault C, Gunn J and Evans PC
Cardiovascular Research, Oxford University Press (Oup) vol. 112 (3), 689-701.  
26-09-2016
Local membrane length conservation in two-dimensional vesicle simulation using a multicomponent lattice Boltzmann equation method
Halliday I, Lishchuk SV, Spencer TJ, Pontrelli G and Evans PC
Physical Review E, American Physical Society (Aps) vol. 94 (2) 
01-08-2016
Sulforaphane induces neurovascular protection against a systemic inflammatory challenge via both Nrf2-dependent and independent pathways
Holloway PM, Gillespie S, Becker F, Vital SA, Nguyen V, Alexander JS, Evans PC and Gavins FNE
Vascular Pharmacology, Elsevier vol. 85, 29-38.  
08-07-2016
211 Non-Canonical NF-Κb Signalling Promotes Endothelial Proliferation in Response to Low Wall Shear Stress
Bowden N, Feng S, Francis S and Evans P
Heart, Bmj vol. 102 (Suppl 6) 
01-06-2016
191 Atheroprone Flow Alters ATP-Induced Calcium Signalling in the Endothelium
Green J, Evans P and Wilson H
Heart, Bmj vol. 102 (Suppl 6) 
01-06-2016
TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis
Mahmoud MM, Kim HR, Xing R, Hsiao S, Mammoto A, Chen J, Serbanovic-Canic J, Feng S, Bowden NP, Maguire R, Ariaans M, Francis SE, Weinberg PD, van der Heiden K, Jones EA, Chico TJA, Ridger V and Evans PC
Circulation Research, Wolters Kluwer vol. 119 (3), 450-462.  
31-05-2016
Experimental Approaches to Study Endothelial Responses to Shear Stress
Bowden N, Bryan MT, Duckles H, Feng S, Hsiao S, Kim HR, Mahmoud M, Moers B, Serbanovic-Canic J, Xanthis I, Ridger VC and Evans PC
Antioxidants & Redox Signaling, Mary Ann Liebert vol. 25 (7), 389-400.  
30-03-2016
Role of biomechanical forces in the natural history of coronary atherosclerosis
Brown AJ, Teng Z, Evans PC, Gillard JH, Samady H and Bennett MR
Nature Reviews Cardiology, Springer Nature vol. 13 (4), 210-220.  
29-01-2016
Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries
Luong L, Duckles H, Schenkel T, Mahmoud M, Tremoleda JL, Wylezinska-Arridge M, Ali M, Bowden NP, Villa-Uriol M-C, van der Heiden K, Xing R, Gijsen FJ, Wentzel J, Lawrie A, Feng S, Arnold N, Gsell W, Lungu A, Hose R, Spencer T, Halliday I, Ridger V and Evans PC
Thrombosis and Haemostasis, Thieme vol. 116 (01), 181-190.  
01-01-2016
Biomechanics in vascular biology and cardiovascular disease
Evans PC, Gijsen FJH, Wentzel JJ and van der Heiden K
Thrombosis and Haemostasis, Thieme vol. 115 (03), 465-466.  
01-01-2016
How does blood flow regulate vascular notch signalling?
Maguire R, Duckles H, Evans PC and Chico T
Atherosclerosis, Elsevier vol. 244 
01-01-2016

2015

Mini Bypass and Proinflammatory Leukocyte Activation: A Randomized Controlled Trial
Nguyen BAV, Fiorentino F, Reeves BC, Baig K, Athanasiou T, Anderson JR, Haskard DO, Angelini GD and Evans PC
The Annals of Thoracic Surgery, Elsevier vol. 101 (4), 1454-1463.  
18-11-2015
Computational fluid dynamics modelling in cardiovascular medicine
Morris PD, Narracott A, von Tengg-Kobligk H, Soto DAS, Hsiao S, Lungu A, Evans P, Bressloff NW, Lawford PV, Hose DR and Gunn JP
Heart, Bmj vol. 102 (1) 
28-10-2015
Vascular dysfunction in the pathogenesis of Alzheimer's disease — A review of endothelium-mediated mechanisms and ensuing vicious circles
Di Marco LY, Venneri A, Farkas E, Evans PC, Marzo A and Frangi AF
Neurobiology of Disease, Elsevier vol. 82, 593-606.  
23-08-2015
Novel methodologies for biomarker discovery in atherosclerosis
Hoefer IE, Steffens S, Ala-Korpela M, Bäck M, Badimon L, Bochaton-Piallat M-L, Boulanger CM, Caligiuri G, Dimmeler S, Egido J, Evans PC, Guzik T, Kwak BR, Landmesser U, Mayr M, Monaco C, Pasterkamp G, Tuñón J and Weber C
European Heart Journal, Oxford University Press (Oup) vol. 36 (39), 2635-2642.  
05-06-2015
185 Shear Stress Dependent Regulation of p2x4 and p2x7 Receptors in the Endothelium
Green J, Wilson H and Evans P
Heart, Bmj vol. 101 (Suppl 4) 
01-06-2015
192 Dietary Docosahexaenoic Acid Reduced Experimental Atherosclerosis by Inducing Protective Haemodynamic Conditions
Alfaidi M, Schenkel T, Evans P, Chamberlain J and Francis S
Heart, Bmj vol. 101 (Suppl 4) 
01-06-2015
YIA2 Neutrophil Microvesicles Influence Atherogenesis and Contain Mirna
Gomez I, Ward B, Evans P, Hellewell P and Ridger V
Heart, Bmj vol. 101 (Suppl 4) 
01-06-2015
204 Disturbed Flow Promotes Atherogenesis through the Activation of Endothelial-Mesenchymal Transition
Mahmoud M, Kim R, Hsiao S, Xing R, Van der Heiden K, Mammoto A, Chen J, Gauci I, Feng S and Evans P
Heart, Bmj vol. 101 (Suppl 4) 
01-06-2015
Abstract 558: Neutrophils-derived-microvesicle Could Play a Role in the Early Stage of Atherosclerosis
Gomez I, Ward B, Evans P, Hellewell P and Ridger V
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 35 (suppl_1) 
01-05-2015
NR2 antibody is associated with quality of life in aortic valve replacement
Kidher E, Jarral OA, Harling L, Anderson JR, Chukwuemeka A, Ashrafian H, Evans PC and Athanasiou T
Asian Cardiovascular and Thoracic Annals, Sage Publications vol. 23 (6), 690-700.  
29-04-2015
PKCε-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis
Mylroie H, Dumont O, Bauer A, Thornton CC, Mackey J, Calay D, Hamdulay SS, Choo JR, Boyle JJ, Samarel AM, Randi AM, Evans PC and Mason JC
Cardiovascular Research, Oxford University Press (Oup) vol. 106 (3), 509-519.  
16-04-2015
A20 suppresses vascular inflammation by recruiting proinflammatory signaling molecules to intracellular aggresomes
Enesa K, Moll HP, Luong L, Ferran C and Evans PC
The Faseb Journal, Wiley vol. 29 (5), 1869-1878.  
09-02-2015

2014

Identification of a molecular switch controlling the induction of senescence or quiescence by flow
Duckles H, Mahmoud M, Hsiao S, Gauci I, Bowden N, Luong L and Evans PC
Atherosclerosis, Elsevier vol. 237 (2) 
01-12-2014
Disturbed flow induces expression of the negative NF-kappaB regulator Cezanne
Bowden N, Duckles H, Mahmoud M, Hsiao S, Francis SE and Evans PC
Atherosclerosis, Elsevier vol. 237 (2) 
01-12-2014
Disturbed flow influences endothelial activation by inducing homeobox transcription factors
Gauci I, Mahmoud M, Duckles H, Feng S, Hsiao S and Evans PC
Atherosclerosis, Elsevier vol. 237 (2) 
01-12-2014
GATA4 promotes endothelial cell turnover at regions of arteries exposed to disturbed flow
Mahmoud M, Hsiao S, Gauci I, Kim HR and Evans PC
Atherosclerosis, Elsevier vol. 237 (2), e2-e3.  
01-12-2014
Biomechanical factors in atherosclerosis: mechanisms and clinical implications†
Kwak BR, Bäck M, Bochaton-Piallat M-L, Caligiuri G, Daemen MJAP, Davies PF, Hoefer IE, Holvoet P, Jo H, Krams R, Lehoux S, Monaco C, Steffens S, Virmani R, Weber C, Wentzel JJ and Evans PC
European Heart Journal, Oxford University Press (Oup) vol. 35 (43), 3013-3020.  
17-09-2014
Piezo1 integration of vascular architecture with physiological force
Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, Sedo A, Hyman AJ, McKeown L, Young RS, Yuldasheva NY, Majeed Y, Wilson LA, Rode B, Bailey MA, Kim HR, Fu Z, Carter DAL, Bilton J, Imrie H, Ajuh P, Dear TN, Cubbon RM, Kearney MT, Prasad KR, Evans PC, Ainscough JFX and Beech DJ
Nature, Springer Nature vol. 515 (7526), 279-282.  
10-08-2014
In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106
Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ, Kwak BR, Bird J, Davenport AP, Clark J, Haskard D, Krams R, Jones H and Evans PC
Molecular Imaging, Sage Publications vol. 13 (6) 
01-08-2014
292Endothelial cell forward migration in a disturbed wall shear stress environment is promoted by ROCK inhibition
Hsiao S, Tovar-Lopez F, Gunn J, Spencer T, Halliday I, Perrault C and Evans P
Cardiovascular Research, Oxford University Press (Oup) vol. 103 (suppl_1), s53-s53.  
27-06-2014
Mechanoresponsive Networks Controlling Vascular Inflammation
Bryan MT, Duckles H, Feng S, Hsiao ST, Kim HR, Serbanovic-Canic J and Evans PC
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 34 (10), 2199-2205.  
19-06-2014
Aortic stiffness as a marker of cardiac function and myocardial strain in patients undergoing aortic valve replacement
Kidher E, Harling L, Ashrafian H, Naase H, Francis DP, Evans P and Athanasiou T
Journal of Cardiothoracic Surgery, Springer Nature vol. 9 (1) 
17-06-2014
Metabolic derangement and cardiac injury early after reperfusion following intermittent cross-clamp fibrillation in patients undergoing coronary artery bypass graft surgery using conventional or miniaturized cardiopulmonary bypass
Nguyen BAV, Suleiman M-S, Anderson JR, Evans PC, Fiorentino F, Reeves BC and Angelini GD
Molecular and Cellular Biochemistry, Springer Nature vol. 395 (1-2), 167-175.  
17-06-2014
Aortic stiffness is an indicator of cognitive dysfunction before and after aortic valve replacement for aortic stenosis
Kidher E, Harling L, Sugden C, Ashrafian H, Casula R, Evans P, Nihoyannopoulos P and Athanasiou T
Interdisciplinary Cardiovascular and Thoracic Surgery, Oxford University Press (Oup) vol. 19 (4), 595-604.  
13-06-2014
Requirement of JNK1 for endothelial cell injury in atherogenesis
Amini N, Boyle JJ, Moers B, Warboys CM, Malik TH, Zakkar M, Francis SE, Mason JC, Haskard DO and Evans PC
Atherosclerosis, Elsevier vol. 235 (2), 613-618.  
12-06-2014
219 Rock Inhibits Endothelial Migration in Disturbed flow Condition: A Potential Therapeutic Target in PCI
Hsiao S, Tovar F, Gunn J, Spencer T, Halliday I, Perrault C and Evans P
Heart, Bmj vol. 100 (Suppl 3) 
31-05-2014
Abstract 266: Disturbed Flow Promotes Endothelial Cell Injury via the Induction of Developmental Genes
Mahmoud M, Kim R, de Luca A, Gauci I, Hsiao S and Evans PC
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 34 (suppl_1) 
01-05-2014
Abstract 521: Endothelial Cell Forward Migration in a Disturbed Wall Shear Stress Environment is Promoted by Rho-Kinase Inhibition
Hsiao S, Tovar-Lopez F, Gunn J, Spencer T, Halliday I, Perrault C and Evans P
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 34 (suppl_1) 
01-05-2014
Abstract 258: A Pharmacological Approach to Promote Shear Stress-Dependent Anti-inflammatory Mechanisms in Arteries
Luong L, Duckles H, Schenkel T, Arnold N, Gsell W, Lungu A, Spencer T, Hose R, Halliday I and Evans P
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 34 (suppl_1) 
01-05-2014
Disturbed Flow Promotes Endothelial Senescence via a p53-Dependent Pathway
Warboys CM, de Luca A, Amini N, Luong L, Duckles H, Hsiao S, White A, Biswas S, Khamis R, Chong CK, Cheung W-M, Sherwin SJ, Bennett MR, Gil J, Mason JC, Haskard DO and Evans PC
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 34 (5), 985-995.  
20-03-2014
Sulforaphane pretreatment prevents systemic inflammation and renal injury in response to cardiopulmonary bypass
Nguyen B, Luong L, Naase H, Vives M, Jakaj G, Finch J, Boyle J, Mulholland JW, Kwak J-H, Pyo S, de Luca A, Athanasiou T, Angelini G, Anderson J, Haskard DO and Evans PC
Journal of Thoracic and Cardiovascular Surgery, Elsevier vol. 148 (2), 690-697.e3.  
15-01-2014
The Biology of A20-Like Molecules
Enesa K and Evans P
In The Multiple Therapeutic Targets of A20, Springer Nature 33-48.  
01-01-2014

2013

Control of tissue morphology by Fasciclin III-mediated intercellular adhesion
Wells RE, Barry JD, Warrington SJ, Cuhlmann S, Evans P, Huber W, Strutt D and Zeidler MP
Development, The Company of Biologists vol. 140 (18), 3858-3868.  
14-08-2013
Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells
Bovens SM, Foin N, O'Clery N, Van Der Heiden K, Cuhlmann S, Carlsen H, Barahona M, Evans PC and Krams R
European Heart Journal, Oxford University Press (Oup) vol. 34 (suppl_1) 
02-08-2013
Biomechanical factors in cardiovascular disease
Evans PC and Kwak BR
Cardiovascular Research, Oxford University Press (Oup) vol. 99 (2), 229-231.  
03-06-2013
YIA4: IDENTIFICATION OF NOVEL SHEAR STRESS-RESPONSIVE REGULATORS OF ENDOTHELIAL CELL DYSFUNCTION USING THE ZEBRAFISH MODEL
Serbanovic-Canic J, de Luca A, Warboys C, Chico T and Evans P
Heart, Bmj vol. 99 (suppl 2) 
01-05-2013
170 TRANSCRIPTOME PROFILING IN PORCINE ARTERIES TO IDENTIFY NOVEL SHEAR-RESPONSIVE REGULATORS OF ENDOTHELIAL CELL FATE
De Luca A, Warboys C, Amini N, Ferreira P, Firmin D, Mason J, Sherwin S and Evans P
Heart, Bmj vol. 99 (suppl 2) 
01-05-2013
The effects of stenting on shear stress: relevance to endothelial injury and repair
Van der Heiden K, Gijsen FJH, Narracott A, Hsiao S, Halliday I, Gunn J, Wentzel JJ and Evans PC
Cardiovascular Research, Oxford University Press (Oup) vol. 99 (2), 269-275.  
15-04-2013
Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting TRAF6 for Deubiquitination
Luong LA, Fragiadaki M, Smith J, Boyle J, Lutz J, Dean JLE, Harten S, Ashcroft M, Walmsley SR, Haskard DO, Maxwell PH, Walczak H, Pusey C and Evans PC
Circulation Research, Wolters Kluwer vol. 112 (12), 1583-1591.  
05-04-2013
Loss of Function of Parathyroid Hormone Receptor 1 Induces Notch-Dependent Aortic Defects During Zebrafish Vascular Development
Gray C, Bratt D, Lees J, daCosta M, Plant K, Watson OJ, Solaymani-Kohal S, Tazzyman S, Serbanovic-Canic J, Crossman DC, Keavney BD, Haase A, McMahon K, Gering M, Roehl H, Evans PC and Chico TJA
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 33 (6), 1257-1263.  
04-04-2013
Cytoprotective Signaling and Gene Expression in Endothelial Cells and Macrophages—Lessons for Atherosclerosis
Haskard DO, Boyle JJ, Evans PC, Mason JC and Randi AM
Microcirculation, Wiley vol. 20 (3), 203-216.  
01-04-2013

2012

Regulation of Endothelial Activation and Vascular Inflammation by Shear Stress
Nayak A, König CS, Kishore U and Evans PC
In Micro and Nano Flow Systems For Bioanalysis, Springer Nature 77-85.  
01-11-2012
General Report & Recommendations in Predictive, Preventive and Personalised Medicine 2012: White Paper of the European Association for Predictive, Preventive and Personalised Medicine
Golubnitschaja O, Costigliola V and EPMA
Epma Journal, Springer Nature vol. 3 (1) 
01-11-2012
Protein kinase Cϵ activity induces anti-inflammatory and anti-apoptotic genes via an ERK1/2- and NF-κB-dependent pathway to enhance vascular protection
Dumont O, Mylroie H, Bauer A, Calay D, Sperone A, Thornton C, Hamdulay SS, Ali N, Boyle JJ, Choo JR, Samarel AM, Haskard DO, Randi AM, Evans PC and Mason JC
Biochemical Journal, Portland Press vol. 447 (2), 193-204.  
26-09-2012
Solid-Phase Immunoglobulins IgG and IgM Activate Macrophages with Solid-Phase IgM Acting via a Novel Scavenger Receptor A Pathway
Boyle JJ, Christou I, Iqbal MB, Nguyen AT, Leung VWY, Evans PC, Liu Y, Johns M, Kirkham P and Haskard DO
American Journal of Pathology, Elsevier vol. 181 (1), 347-361.  
30-05-2012
Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells
Pfenniger A, Wong C, Sutter E, Cuhlmann S, Dunoyer-Geindre S, Mach F, Horrevoets AJ, Evans PC, Krams R and Kwak BR
Journal of Molecular and Cellular Cardiology, Elsevier vol. 53 (2), 299-309.  
29-05-2012
Implantation of a carotid cuff for triggering shear-stress induced atherosclerosis in mice.
Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S and Schäfers M
Journal of Visualized Experiments, Myjove (59) 
13-01-2012
Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S and Schäfers M
Journal of Visualized Experiments, Myjove (59) 
13-01-2012

2011

Heme Induces Heme Oxygenase 1 via Nrf2
Boyle JJ, Johns M, Lo J, Chiodini A, Ambrose N, Evans PC, Mason JC and Haskard DO
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 31 (11), 2685-2691.  
01-11-2011
Inhibition of NF-kB signaling in human dendritic cells the enterpathogenic Escherichia coli effector protein NIeE
Vossenkämper A, Marchès O, Fairclough PD, Warnes G, Stagg AJ, Lindsay JO, Evans PC, Luong LA, Croft NM, Naik S, Frankel G and MacDonald TT
J Immunol, The American Association of Immunologists, Inc vol. 185, 4118-4127.  
20-10-2011
Targeting Inhibitor of Apoptosis Proteins to Block Vascular Inflammation
Luong LA and Evans PC
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 31 (10), 2165-2166.  
01-10-2011
Do Miniaturized Extracorporeal Circuits Confer Significant Clinical Benefit Without Compromising Safety? A Meta-Analysis of Randomized Controlled Trials
Harling L, Warren OJ, Martin A, Kemp PR, Evans PC, Darzi A and Athanasiou T
Asaio Journal, Wolters Kluwer vol. 57 (3), 141-151.  
01-05-2011
Disturbed Blood Flow Induces RelA Expression via c-Jun N-Terminal Kinase 1
Cuhlmann S, Van der Heiden K, Saliba D, Tremoleda JL, Khalil M, Zakkar M, Chaudhury H, Luong LA, Mason JC, Udalova I, Gsell W, Jones H, Haskard DO, Krams R and Evans PC
Circulation Research, Wolters Kluwer vol. 108 (8), 950-959.  
24-02-2011
The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease
Evans PC
Epma Journal, Springer Nature vol. 2 (1), 9-14.  
12-02-2011
When stress is good
Warboys CM, Amini N, Luca AD and Evans PC
Scientist vol. 25 (2) 
01-02-2011
Dexamethasone Arterializes Venous Endothelial Cells by Inducing Mitogen-Activated Protein Kinase Phosphatase-1
Zakkar M, Luong LA, Chaudhury H, Ruud O, Punjabi PP, Anderson JR, Mullholand JW, Clements AT, Krams R, Foin N, Athanasiou T, Leen ELS, Mason JC, Haskard DO and Evans PC
Circulation, Wolters Kluwer vol. 123 (5), 524-532.  
24-01-2011
18FEDAA is a more specific probe than 18FDG for imaging vascular inflammation
Gsell W, Cuhlmann S, Van der Heiden K, Tremoleda JL, Khalil M, Clark J, Bird J, Jones H, Krams R and Evans PC
European Journal of Nuclear Medicine and Molecular Imaging vol. 38, S210-S210.  
01-01-2011
The role of blood flow in determining the sites of atherosclerotic plaques
Warboys CM, Amini N, de Luca A and Evans PC
F1000 Medicine Reports, H1 Connect vol. 3 
01-01-2011

2010

Multi-scale interaction of particulate flow and the artery wall
Halliday I, Atherton M, Care CM, Collins MW, Evans D, Evans PC, Hose DR, Khir AW, König CS, Krams R, Lawford PV, Lishchuk SV, Pontrelli G, Ridger V, Spencer TJ, Ventikos Y, Walker DC and Watton PN
Medical Engineering & Physics, Elsevier vol. 33 (7), 840-848.  
29-10-2010
The Transcription Factor Erg Inhibits Vascular Inflammation by Repressing NF-&kgr;B Activation and Proinflammatory Gene Expression in Endothelial Cells
Sperone A, Dryden NH, Birdsey GM, Madden L, Johns M, Evans PC, Mason JC, Haskard DO, Boyle JJ, Paleolog EM and Randi AM
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 31 (1), 142-150.  
21-10-2010
YIA4 C Jun N-terminal kinase promotes endothelial activation at atherosclerosis-susceptible sites by enhancing expression of NF-κB transcription factors
Cuhlmann S, van der Heiden K, Zakkar M, Chaudhury H, Luong LA, Mason J, Haskard DO, Carlsen H, Krams R and Evans PC
Heart, Bmj vol. 96 (17) 
26-08-2010
Smooth muscle cells in porcine vein graft intimal hyperplasia are derived from the local vessel wall
Jevon M, Ansari TI, Finch J, Zakkar M, Evans PC, Shurey S, Sibbons PD, Hornick P, Haskard DO and Dorling A
Cardiovascular Pathology, Elsevier vol. 20 (3), e91-e94.  
07-06-2010
Role of nuclear factor κB in cardiovascular health and disease
van der Heiden K, Cuhlmann S, Luong LA, Zakkar M and Evans PC
Clinical Science, Portland Press vol. 118 (10), 593-605.  
23-02-2010
Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium
Hamdulay SS, Wang B, Birdsey GM, Ali F, Dumont O, Evans PC, Haskard DO, Wheeler-Jones CP and Mason JC
Free Radical Biology and Medicine, Elsevier vol. 48 (8), 1013-1023.  
18-01-2010
c-Jun N-Terminal Kinase Primes Endothelial Cells at Atheroprone Sites for Apoptosis
Chaudhury H, Zakkar M, Boyle J, Cuhlmann S, van der Heiden K, Luong LA, Davis J, Platt A, Mason JC, Krams R, Haskard DO, Clark AR and Evans PC
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 30 (3), 546-553.  
07-01-2010
Shear stress, inflammation and Atherosclerosis
Krams R, Cuhlmann S, Foin N and Evans P
Artery Research, Springer Nature vol. 4 (2), 41-46.  
01-01-2010

2009

Perfusion of veins at arterial pressure increases the expression of KLF5 and cell cycle genes in smooth muscle cells
Amirak E, Zakkar M, Evans PC and Kemp PR
Biochemical and Biophysical Research Communications, Elsevier vol. 391 (1), 818-823.  
02-12-2009
Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State
Zakkar M, Van der Heiden K, Luong LA, Chaudhury H, Cuhlmann S, Hamdulay SS, Krams R, Edirisinghe I, Rahman I, Carlsen H, Haskard DO, Mason JC and Evans PC
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 29 (11), 1851-1857.  
03-09-2009
Induction of the Cytoprotective Enzyme Heme Oxygenase-1 by Statins Is Enhanced in Vascular Endothelium Exposed to Laminar Shear Stress and Impaired by Disturbed Flow*
Ali F, Zakkar M, Karu K, Lidington EA, Hamdulay SS, Boyle JJ, Zloh M, Bauer A, Haskard DO, Evans PC and Mason JC
Journal of Biological Chemistry, Elsevier vol. 284 (28), 18882-18892.  
19-05-2009
Nur77
Evans PC
Circulation Research, Wolters Kluwer vol. 104 (6), 707-709.  
27-03-2009

2008

Effects of shear stress on endothelial activation and vascular inflammation
Evans PC
Biomedicine & Pharmacotherapy, Elsevier vol. 62 (8), 503-504.  
01-10-2008
The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation
Lutz J, Luong LA, Strobl M, Deng M, Huang H, Anton M, Zakkar M, Enesa K, Chaudhury H, Haskard DO, Baumann M, Boyle J, Harten S, Maxwell PH, Pusey C, Heemann U and Evans PC
Journal of Molecular Medicine, Springer Nature vol. 86 (12), 1329-1339.  
24-09-2008
Increased Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Expression Suppresses Proinflammatory Activation at Sites That Are Resistant to Atherosclerosis
Zakkar M, Chaudhury H, Sandvik G, Enesa K, Luong LA, Cuhlmann S, Mason JC, Krams R, Clark AR, Haskard DO and Evans PC
Circulation Research, Wolters Kluwer vol. 103 (7), 726-732.  
21-08-2008
Hemodynamic parameters regulating vascular inflammation and atherosclerosis: A brief update
Ridger V, Krams R, Carpi A and Evans PC
Biomedicine & Pharmacotherapy, Elsevier vol. 62 (8), 536-540.  
08-08-2008
Hydrogen Peroxide Prolongs Nuclear Localization of NF-κB in Activated Cells by Suppressing Negative Regulatory Mechanisms*
Enesa K, Ito K, Luong LA, Thorbjornsen I, Phua C, To Y, Dean J, Haskard DO, Boyle J, Adcock I and Evans PC
Journal of Biological Chemistry, Elsevier vol. 283 (27), 18582-18590.  
12-05-2008
Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy
Birks EJ, Latif N, Enesa K, Folkvang T, Luong LA, Sarathchandra P, Khan M, Ovaa H, Terracciano CM, Barton PJR, Yacoub MH and Evans PC
Cardiovascular Research, Oxford University Press (Oup) vol. 79 (3), 472-480.  
02-05-2008
KLF‐2‐dependent, shear stress‐induced expression of CD59: a novel cytoprotective mechanism against complement‐mediated injury in the vasculature
Mason JC, Kinderlerer A, Ali F, Johns M, Leung V, Boyle J, Evans P and Haskard DO
The Faseb Journal, Wiley vol. 22 (S1), 471.2-471.2.  
01-03-2008
Atherosclerosis: cell biology and lipoproteins – new developments in imaging of inflammation of the vulnerable plaque
Foin N, Evans P and Krams R
Current Opinion in Lipidology, Wolters Kluwer vol. 19 (1), 98-100.  
01-02-2008
NF-κB Suppression by the Deubiquitinating Enzyme Cezanne A NOVEL NEGATIVE FEEDBACK LOOP IN PRO-INFLAMMATORY SIGNALING*
Enesa K, Zakkar M, Chaudhury H, Luong LA, Rawlinson L, Mason JC, Haskard DO, Dean JLE and Evans PC
Journal of Biological Chemistry, Elsevier vol. 283 (11), 7036-7045.  
04-01-2008

2007

Effect of shear stress on vascular inflammation and plaque development
Helderman F, Segers D, de Crom R, Hierck BP, Poelmann RE, Evans PC and Krams R
Current Opinion in Lipidology, Wolters Kluwer vol. 18 (5), 527-533.  
01-10-2007
Chains of command: Ubiquitin in proinflammatory signalling
Evans KEAPC
The Biochemist, Portland Press vol. 29 (4), 24-27.  
01-08-2007
Laminar shear stress acts as a switch to regulate divergent functions of NF‐κB in endothelial cells
Partridge J, Carlsen H, Enesa K, Chaudhury H, Zakkar M, Luong L, Kinderlerer A, Johns M, Blomhoff R, Mason JC, Haskard DO and Evans PC
The Faseb Journal, Wiley vol. 21 (13), 3553-3561.  
08-06-2007

2006

The triage of damaged proteins: degradation by the ubiquitin‐proteasome pathway or repair by molecular chaperones
Marques C, Guo W, Pereira P, Taylor A, Patterson C, Evans PC and Shang F
The Faseb Journal, Wiley vol. 20 (6), 741-743.  
09-02-2006

2005

Regulation of pro-inflammatory signalling networks by ubiquitin: identification of novel targets for anti-inflammatory drugs
Evans PC
Expert Reviews in Molecular Medicine, Cambridge University Press (Cup) vol. 7 (12), 1-19.  
20-06-2005
Donor CD31 genotype and its association with acute graft-versus-host disease in HLA identical sibling stem cell transplantation
Goodman RS, Ewing J, Evans PC, Craig J, Poulton K, Dyer PA, Marcus RE and Taylor CJ
Bone Marrow Transplantation, Springer Nature vol. 36 (2), 151-156.  
23-05-2005

2004

Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity
EVANS PC, Huib O, HAMON M, KILSHAW PJ, Svetlana H, BAUER S, PLOEGH HL and SMITH TS
Biochemical Journal, Portland Press vol. 378 (3), 727-734.  
15-03-2004

2003

A Novel Type of Deubiquitinating Enzyme*
Evans PC, Smith TS, Lai M-J, Williams MG, Burke DF, Heyninck K, Kreike MM, Beyaert R, Blundell TL and Kilshaw PJ
Journal of Biological Chemistry, Elsevier vol. 278 (25), 23180-23186.  
07-04-2003

2001

Isolation and characterization of two novel A20-like proteins.
Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R and Kilshaw PJ
Biochemical Journal, Portland Press vol. 357 (Pt 3), 617-623.  
01-08-2001
Isolation and characterization of two novel A20-like proteins
EVANS PC, TAYLOR ER, COADWELL J, HEYNINCK K, BEYAERT R and KILSHAW PJ
Biochemical Journal, Portland Press vol. 357 (3), 617-623.  
25-07-2001
Recognition of E-cadherin by Integrin αEβ7 REQUIREMENT FOR CADHERIN DIMERIZATION AND IMPLICATIONS FOR CADHERIN AND INTEGRIN FUNCTION*
Corps E, Carter C, Karecla P, Ahrens T, Evans P and Kilshaw P
Journal of Biological Chemistry, Elsevier vol. 276 (33), 30862-30870.  
18-06-2001
Recipient HLA-DR3, tumour necrosis factor-α promoter allele-2 (tumour necrosis factor-2) and cytomegalovirus infection are inter-related risk factors for chronic rejection of liver grafts
Evans PC, Smith S, Hirschfield G, Rigopoulou E, Wreghitt TG, Wight DGD, Taylor CJ and Alexander GJM
Journal of Hepatology, Elsevier vol. 34 (5), 711-715.  
01-05-2001
SIGNALING THROUGH CD31 PROTECTS ENDOTHELIAL CELLS FROM APOPTOSIS
Evans PC, Taylor ER and Kilshaw PJ
Transplantation, Wolters Kluwer vol. 71 (3), 457-460.  
01-02-2001
Signaling Through CD31 Protects Endothelial Cells from Apoptosis. Transplantation 2001; 71: 457.
Buckley CD
Transplantation, Wolters Kluwer vol. 71 (3), 343-344.  
01-02-2001

2000

INTERLEUKIN-13 PROTECTS ENDOTHELIAL CELLS FROM APOPTOSIS AND ACTIVATION
Evans PC and Kilshaw PJ
Transplantation, Wolters Kluwer vol. 70 (6), 928-934.  
01-09-2000
Cutting Edge: Persistent Fetal Microchimerism in T Lymphocytes Is Associated with HLA-DQA1*0501: Implications in Autoimmunity
Lambert NC, Evans PC, Hashizumi TL, Maloney S, Gooley T, Furst DE and Nelson JL
The Journal of Immunology, The American Association of Immunologists vol. 164 (11), 5545-5548.  
01-06-2000
AN ASSOCIATION BETWEEN CYTOMEGALOVIRUS INFECTION AND CHRONIC REJECTION AFTER LIVER TRANSPLANTATION
Evans PC, Soin A, Wreghitt TG, Taylor CJ, Wight DGD and Alexander GJM
Transplantation, Wolters Kluwer vol. 69 (1) 
01-01-2000

1999

Comparison of three PCR techniques for detecting cytomegalovirus (CMV) DNA in serum, detection of early antigen fluorescent foci and culture for the diagnosis of CMV infection
EVANS PC, GRAY JJ, WREGHITT TG, MARCUS RE and ALEXANDER GJM
Journal of Medical Microbiology, Microbiology Society vol. 48 (11), 1029-1035.  
01-11-1999
Cytomegalovirus infection of bile duct epithelial cells, hepatic artery and portal venous endothelium in relation to chronic rejection of liver grafts
Evans PC, Coleman N, Wreghitt TG, Wight DGD and Alexander GJM
Journal of Hepatology, Elsevier vol. 31 (5), 913-920.  
01-11-1999
α-GALACTOSYL-MEDIATED ACTIVATION OF PORCINE ENDOTHELIAL CELLS
Nasu K, Whyte A, Green SJ, Evans PC and Kilshaw PJ
Transplantation, Wolters Kluwer vol. 68 (6), 861-867.  
01-09-1999
Microchimerism of maternal origin persists into adult life
Maloney S, Smith A, Furst DE, Myerson D, Rupert K, Evans PC and Nelson JL
Journal of Clinical Investigation, American Society For Clinical Investigation vol. 104 (1), 41-47.  
01-07-1999
Long-Term Fetal Microchimerism in Peripheral Blood Mononuclear Cell Subsets in Healthy Women and Women With Scleroderma
Evans PC, Lambert N, Maloney S, Furst DE, Moore JM and Nelson JL
Blood, American Society of Hematology vol. 93 (6), 2033-2037.  
15-03-1999

1998

Qualitative and semiquantitative polymerase chain reaction testing for cytomegalovirus DNA in serum allows prediction of CMV related disease in liver transplant recipients.
Evans PC, Soin A, Wreghitt TG and Alexander GJ
Journal of Clinical Pathology, Bmj vol. 51 (12) 
01-12-1998
Optimisation of the polymerase chain reaction and dot-blot hybridisation for detecting cytomegalovirus DNA in urine: comparison with detection of early antigen fluorescent foci and culture
Evans PC, Gray J, Wreghitt TG and Alexander GJM
Journal of Virological Methods, Elsevier vol. 73 (1), 41-52.  
01-07-1998
Microchimerism and HLA-compatible relationships of pregnancy in scleroderma
Nelson JL, Furst DE, Maloney S, Gooley T, Evans PC, Smith A, Bean MA, Ober C and Bianchi DW
The Lancet, Elsevier vol. 351 (9102), 559-562.  
01-02-1998