Dr Pradeepa Madapura

Pradeepa Madapura

Senior Lecturer

Blizard Institute
Queen Mary University of London
ORCID Google Scholar X

Research

Neurodevelopmental disorders, brain organoids, In vitro brain development, neuroepigenetics, functional genomics

Cardiovascular Models, Neuronal Models

Interests

We use human stem cell-derived cerebral organoid models to investigate the mechanism through which mutations in epigenetic regulators contribute to neurodevelopmental and cardiovascular disorders.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2024

Author Correction: PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrity
Jayakumar S, Patel M, Boulet F, Aziz H, Brooke GN, Tummala H and Pradeepa MM
Nature Communications, Springer Nature vol. 15 (1) 
07-06-2024
Nucleosome reorganisation in breast cancer tissues
Jacob DR, Guiblet WM, Mamayusupova H, Shtumpf M, Ciuta I, Ruje L, Gretton S, Bikova M, Correa C, Dellow E, Agrawal SP, Shafiei N, Drobysevskaja A, Armstrong CM, Lam JDG, Vainshtein Y, Clarkson CT, Thorn GJ, Sohn K, Pradeepa MM, Chandrasekharan S, Brooke GN, Klenova E, Zhurkin VB and Teif VB
Clinical Epigenetics, Springer Nature vol. 16 (1) 
01-04-2024
PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrity
Jayakumar S, Patel M, Boulet F, Aziz H, Brooke GN, Tummala H and Pradeepa MM
Nature Communications, Springer Nature vol. 15 (1) 
08-01-2024

2023

H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function
Pal D, Patel M, Boulet F, Sundarraj J, Grant OA, Branco MR, Basu S, Santos SDM, Zabet NR, Scaffidi P and Pradeepa MM
Nature Structural & Molecular Biology, Springer Nature vol. 30 (7), 935-947.  
12-06-2023
Regulatory de novo mutations underlying intellectual disability
De Vas MG, Boulet F, Joshi SS, Garstang MG, Khan TN, Atla G, Parry D, Moore D, Cebola I, Zhang S, Cui W, Lampe AK, Lam WW, Consortium GER, Ferrer J, Pradeepa MM and Atanur SS
Life Science Alliance, Life Science Alliance vol. 6 (5) 
28-02-2023

2022

Genetic variation at mouse and human ribosomal DNA influences associated epigenetic states
Rodriguez-Algarra F, Seaborne RAE, Danson AF, Yildizoglu S, Yoshikawa H, Law PP, Ahmad Z, Maudsley VA, Brew A, Holmes N, Ochôa M, Hodgkinson A, Marzi SJ, Pradeepa MM, Loose M, Holland ML and Rakyan VK
Genome Biology, Springer Nature vol. 23 (1) 
14-02-2022

2021

H3K36me3 and PSIP1/LEDGF associate with several DNA repair proteins, suggesting their role in efficient DNA repair at actively transcribing loci
Sundarraj J, Taylor GCA, von Kriegsheim A and Pradeepa MM
Wellcome Open Research, F1000research vol. 2 
14-09-2021
Cornelia de Lange syndrome-associated mutations cause a DNA damage signalling and repair defect
Olley G, Pradeepa MM, Grimes GR, Piquet S, Polo SE, FitzPatrick DR, Bickmore WA and Boumendil C
Nature Communications, Springer Nature vol. 12 (1) 
25-05-2021

2019

Publisher Correction: BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange–like syndrome
Olley G, Ansari M, Bengani H, Grimes GR, Rhodes J, von Kriegsheim A, Blatnik A, Stewart FJ, Wakeling E, Carroll N, Ross A, Park S-M, Bickmore WA, Pradeepa MM and FitzPatrick DR
Nature Genetics, Springer Nature vol. 51 (7), 1192-1192.  
03-06-2019

2018

An Enhancer-Derived RNA Muscles In to Regulate Myogenin In trans.
Garstang MG and Pradeepa MM
Mol Cell vol. 71 (1), 3-5.  
05-07-2018
Publisher Correction: BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange–like syndrome
Olley G, Ansari M, Bengani H, Grimes GR, Rhodes J, von Kriegsheim A, Blatnik A, Stewart FJ, Wakeling E, Carroll N, Ross A, Park S-M, Bickmore WA, Pradeepa MM, FitzPatrick DR and Deciphering Developmental Disorders Study
Nature Genetics, Springer Nature vol. 50 (5), 767-767.  
12-02-2018
BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange–like syndrome
Olley G, Ansari M, Bengani H, Grimes GR, Rhodes J, von Kriegsheim A, Blatnik A, Stewart FJ, Wakeling E, Carroll N, Ross A, Park S-M, Deciphering Developmental Disorders Study , Bickmore WA, Pradeepa MM and FitzPatrick DR
Nature Genetics, Springer Nature vol. 50 (3), 329-332.  
29-01-2018

2017

Convergent origination of a Drosophila-like dosage compensation mechanism in a reptile lineage
Marin R, Cortez D, Lamanna F, Pradeepa MM, Leushkin E, Julien P, Liechti A, Halbert J, Brüning T, Mössinger K, Trefzer T, Conrad C, Kerver HN, Wade J, Tschopp P and Kaessmann H
Genome Research, Cold Spring Harbor Laboratory vol. 27 (12), 1974-1987.  
13-11-2017
­­­Proteomic analysis of H3K36me3 and PSIP1/p75 (LEDGF) complexes reveal their wider role in DNA repair
Pradeepa MM, Taylor GCA and von Kriegsheim A
Wellcome Open Research, F1000research vol. 2 
12-09-2017
Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip
Pradeepa MM, McKenna F, Taylor GCA, Bengani H, Grimes GR, Wood AJ, Bhatia S and Bickmore WA
Plos Genetics, Public Library of Science (Plos) vol. 13 (4) 
06-04-2017
Causal role of histone acetylations in enhancer function.
Pradeepa MM
Transcription vol. 8 (1), 40-47.  
01-01-2017

2016

Native chromatin immunoprecipitation of histone marks to Identify enhancer status
Marulasiddappa P, Pradeepa MM, Kumar Y, Grimes G, Illingworth R and Bickmore W
Protocol Exchange, Springer Nature 
05-05-2016
Histone H3 globular domain acetylation identifies a new class of enhancers
Pradeepa MM, Grimes GR, Kumar Y, Olley G, Taylor GCA, Schneider R and Bickmore WA
Nature Genetics vol. 48 (6), 681-686.  
18-04-2016
An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway
Robertson KA, Hsieh WY, Forster T, Blanc M, Lu H, Crick PJ, Yutuc E, Watterson S, Martin K, Griffiths SJ, Enright AJ, Yamamoto M, Pradeepa MM, Lennox KA, Behlke MA, Talbot S, Haas J, Dölken L, Griffiths WJ, Wang Y, Angulo A and Ghazal P
Plos Biology, Public Library of Science (Plos) vol. 14 (3) 
03-03-2016

2015

The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development
Illingworth RS, Moffat M, Mann AR, Read D, Hunter CJ, Pradeepa MM, Adams IR and Bickmore WA
Genes & Development, Cold Spring Harbor Laboratory vol. 29 (18), 1897-1902.  
15-09-2015
Mapping of Post-translational Modifications of Transition Proteins, TP1 and TP2, and Identification of Protein Arginine Methyltransferase 4 and Lysine Methyltransferase 7 as Methyltransferase for TP2*
Gupta N, Madapura MP, Bhat UA and Rao MRS
Journal of Biological Chemistry, Elsevier vol. 290 (19), 12101-12122.  
28-03-2015

2014

Psip1/Ledgf p75 restrains Hox gene expression by recruiting both trithorax and polycomb group proteins
Pradeepa MM, Grimes GR, Taylor GCA, Sutherland HG and Bickmore WA
Nucleic Acids Research, Oxford University Press (Oup) vol. 42 (14), 9021-9032.  
23-07-2014

2013

H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction
Taylor GCA, Eskeland R, Hekimoglu-Balkan B, Pradeepa MM and Bickmore WA
Genome Research, Cold Spring Harbor Laboratory vol. 23 (12), 2053-2065.  
29-08-2013

2012

Psip1/Ledgf p52 Binds Methylated Histone H3K36 and Splicing Factors and Contributes to the Regulation of Alternative Splicing
Pradeepa MM, Sutherland HG, Ule J, Grimes GR and Bickmore WA
Plos Genetics, Public Library of Science (Plos) vol. 8 (5) 
01-01-2012

2009

Acetylation of Transition Protein 2 (TP2) by KAT3B (p300) Alters Its DNA Condensation Property and Interaction with Putative Histone Chaperone NPM3*
Pradeepa MM, Nikhil G, Kishore AH, Bharath GN, Kundu TK and Rao MRS
Journal of Biological Chemistry, Elsevier vol. 284 (43), 29956-29967.  
26-08-2009
Spatiotemporal Organization of AT- and GC-rich DNA and Their Association With Transition Proteins TP1 and TP2 in Rat Condensing Spermatids
Kolthur-Seetharam U, Pradeepa MM, Gupta N, Narayanaswamy R and Rao MRS
Journal of Histochemistry & Cytochemistry, Sage Publications vol. 57 (10), 951-962.  
08-06-2009

2008

Involvement of Importin-4 in the Transport of Transition Protein 2 into the Spermatid Nucleus
Pradeepa MM, Manjunatha S, Sathish V, Agrawal S and Rao MRS
Molecular and Cellular Biology, Taylor & Francis vol. 28 (13), 4331-4341.  
01-07-2008

2007

Chromatin remodeling during mammalian spermatogenesis: role of testis specific histone variants and transition proteins.
Pradeepa MM and Rao MRS
Society of Reproduction and Fertility vol. 63, 1-10.  
01-01-2007
Emerging concepts of chromatin remodeling in modulating genome functions
Dhar S, Pradeepa MM and Rao MRS
Proceedings of The National Academy of Sciences India Section B-Biological Sciences vol. 77, 61-71.  
01-01-2007

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconRole of BRD4 mutations in neurodevelopment
Pradeepa Madapura
£759,321 MRC Medical Research Council
01-11-2023 - 31-10-2026
bullet iconRole of BRD4 mutations in neurodevelopment
Pradeepa Madapura and Nicolae Radu Zabet
£205,822 Barts and the London Charity
01-04-2023 - 31-03-2027


bullet iconRole of PSIP1 in prostate cancer development and drug resistance - MSCA IF 2019
Pradeepa Madapura
£179,947 EU Commission - Horizon 2020
05-01-2021 - 18-01-2023
bullet iconDeciphering the role of the MOF complex and H4K16ac in the regulation of neuronal enhancers
Pradeepa Madapura
£821,014 MRC Medical Research Council
01-02-2020 - 31-10-2023
bullet iconEffect of mutations in genes encoding acetyltransferases in neurodevelopmental disorders
Pradeepa Madapura
£40,000 Barts and the London Charity
01-09-2019 - 31-08-2021